Review
Version 1
Preserved in Portico This version is not peer-reviewed
Autoimmune Thyroiditis and Vitamin D
Version 1
: Received: 14 February 2024 / Approved: 22 February 2024 / Online: 23 February 2024 (10:08:09 CET)
A peer-reviewed article of this Preprint also exists.
Durá-Travé, T.; Gallinas-Victoriano, F. Autoimmune Thyroiditis and Vitamin D. Int. J. Mol. Sci. 2024, 25, 3154. Durá-Travé, T.; Gallinas-Victoriano, F. Autoimmune Thyroiditis and Vitamin D. Int. J. Mol. Sci. 2024, 25, 3154.
Abstract
Hashimoto's thyroiditis (HT) is essentially featured by self-tissue destruction by means of the adaptive immune responses that evade immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance. The aim of this study is to elaborate a narrative review about the relationship between vitamin D status and HT and the role of vitamin D supplementation to reduce HT risk by modulating the immune system. There is an extensive literature confirming that vitamin D levels are significantly lower in HT patients compared to healthy people. On the other hand, after the supplementation with cholecalciferol in patients with HT and vitamin D deficiency, thyroid autoantibody titer decreased significantly, However, there are no conclusive results on the effect of vitamin D supplementation on the thyroid function. The confirmation of the beneficial effects of vitamin D in the prevention and treatment of autoimmune thyroid diseases require additional randomized, double-blind, placebo-controlled trials with longer follow-up.
Keywords
Anti-thyroglobulin antibodies; Anti-thyroid peroxidase; Autoimmunity; Autoimmune thyroiditis; Hashimoto thyroiditis; Immune cells; Vitamin D; Vitamin D deficiency; Vitamin D supplementation
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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