Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Proinflammatory Effects of 25-Hydroxyvitamin D3 in New-Onset Type 2 Diabetes Mellitus and Prediabetes

Aysen Kutan Fenercioglu
* ORCID logo ,
Mustafa Sait Gonen
,
Hafize Uzun
ORCID logo ,
Nurver Turfaner Sipahioglu
,
Gunay Can
,
Ebru Tas
,
Zehra Kara
,
Hande Mefkure Ozkaya
,
Pinar Atukeren
Version 1 : Received: 3 October 2023 / Approved: 3 October 2023 / Online: 4 October 2023 (13:09:57 CEST)

A peer-reviewed article of this Preprint also exists.

Fenercioglu, A.K.; Gonen, M.S.; Uzun, H.; Sipahioglu, N.T.; Can, G.; Tas, E.; Kara, Z.; Ozkaya, H.M.; Atukeren, P. The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes. Biomolecules 2023, 13, 1778. Fenercioglu, A.K.; Gonen, M.S.; Uzun, H.; Sipahioglu, N.T.; Can, G.; Tas, E.; Kara, Z.; Ozkaya, H.M.; Atukeren, P. The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes. Biomolecules 2023, 13, 1778.

Abstract

In this study, we aimed to reveal the proinflammatory effects of serum 25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 diabetes mellitus (T2DM) and prediabe-tes. We recruited 84 prediabetes patients, 94 new-onset T2DM patients and 113 healthy partici-pants. Levels of C-reactive protein (CRP), fibrinogen, ferritin, interleukin-1β (IL-1β), interleu-kin-6 (IL-6), interleukin-8 (IL-8), tumour necrosis factor-α (TNF-α), nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) were measured in the serum of the par-ticipants. The ANOVA Bonferonni and Kruskal Wallis Dunn tests were used for the comparison of the inflammation markers and vitamin D levels between the groups. Upon covariance analy-sis with age, gender and BMI; Vit D levels of T2DM group were found to be significantly lower (p<0.003). Proinflammatory markers and CRP were found to be significantly higher in predia-betic and diabetic subjects. In the prediabetes group, IL-1β, IL-6, IL-8, TNF-α and MAPK were significantly higher in those with Vit D insufficiency and deficiency groups. In T2DM group, IL-1β, IL-6, IL-8, TNF-α, NF-κB, MAPK and CRP were significantly higher in those with Vit D insufficiency and deficiency. Our study emphasizes the proinflammatory effects of Vit D on the initiation of inflammation in both prediabetes and diabetes mellitus.

Keywords

Prediabetes, type 2 diabetes mellitus, 25-hydroxyvitamin D3, inflammation, interleukins, TNF-α, NF-kB, MAPK

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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