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Preprint REVIEW | doi:10.20944/preprints201906.0192.v1

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

Arturo Andrade, Ashton Brennecke, Shayna Mallat, Julian Brown, Juan Gomez-Rivadeneira, Natalie Czepiel, Laura Londrigan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: voltage-gated calcium channels; major depressive disorder; autism spectrum disorder; schizophrenia; bipolar disorder; attention-deficit and hyperactivity disorder; anxiety; calcium channel modulators; psychiatric disorders; auxiliary subunits; genetic risk variations

Online: 20 June 2019 (04:16:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1211.v1

Reproducible Exploration of Disease Maps with Galaxy Workflows and the MINERVA Platform

Helena Rasche, Matti Hoch, Julia Scheel, Saskia Hiltemann, Martina Kutmon, Chris T. Evelo, Iacopo Cristoferi, Myrthe van Baardwijk, Andrew Stubbs, Marek Ostaszewski

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Galaxy workflows
disease maps
visual exploration
systems biomedicine

Online: 20 March 2024 (13:30:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0564.v2

Possibility of Assessing Pain with Biomarkers in Psychiatric Disorders

Piotr Jakubow, Urszula Kosciuczuk, Adam Garkowski, Aleksander Turczynowicz, Małgorzata Mojsak, Łukasz Skoworński

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psychiatric disorders; neuroimaging; biochemical; pain; pain biomarkers

Online: 21 June 2021 (16:39:16 CEST)

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According to the literature, patients with chronic pain and mental disorders constitute a huge, heterogeneous group. However, it is known that social and psychological processes closely affect the level and expression of chronic pain. In this paper, we present a review of the literature, define methods of identifying pain biomarkers and consider the possibility of using them to assess pain in mental disorders. Group researchers searched PubMed, Scope, and Cochrane databases for "pain biomarkers in mental disorders" between 2011 and 2021. for available databases for full-text, peer-reviewed studies and review publications using the following keywords: pain biomarkers, neuroimaging pain, pain metabolomics, pain and psychiatric disorders, pain electroencephalography (EEG), serum pain biomarkers, saliva biomarkers, and diagnosis pain. The search included full-text articles, clinical trials, randomized controlled trials, and systematic reviews. Was used part of the PRISMA method to review the literature systematically. A literature search identified 283 studies based on the initially set inclusion and exclusion criteria. In the subsequent selection stages, 11 studies were selected for analysis. There are three main areas of the possible use of biomarkers for the clinical assessment of pain in psychiatric patients, neuroimaging, changes in metabolite levels in body fluids, and changes in gene expression. As a result of the review, individual pain mediators were distinguished that may be markers of pain in psychiatric patients. Some mediators indicate the specificity of pain and are of diagnostic importance. However, despite significant advances in research, most of the described biomarkers found in clinical trials assessing the severity and frequency of pain have no practical significance in psychiatric disorders. It is possible to diagnose pain based on neuroimaging using various methods, genetic methods, body fluids: blood and urine. Of the many, body fluid biomarkers are the most advanced. Discussion: Biomarker research is a dynamically developing field. The review has proposed new ways to diagnose pain by identifying pain biomarkers. Work presented pain diagnostics in psychiatric disorders based on biomarkers from various neuroimaging methods, blood and urine analysis. The possibility of new, effective techniques gives hope for the correct diagnosis of pain, especially in patients with mental disorders, which would allow for appropriate and adequate therapeutic therapies. In clinical practice is limited to a few methods. Assessment of pain biomarkers in body fluids (serum, saliva, and urine) seems to be the most practical and promising method of clinical application. Conclusions: There are new techniques that give hope for the correct diagnosis of pain, especially in patients with mental disorders, which will allow for their proper and adequate therapy. According to the literature, patients with chronic pain and mental disorders constitute a huge, heterogeneous group. However, it is known that social and psychological processes closely affect the level and expression of chronic pain.

Working Paper REVIEW

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Simge Seren Kirlioglu, Yasin Hasan Balcioglu

Subject: Social Sciences, Behavior Sciences Keywords: biological clocks; circadian rhythm disorders; mental disorders; melatonin; HPA-axis

Online: 16 May 2020 (17:18:55 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202402.1644.v2

The Impact of an Online Sleep Education Program (Sleep 101) on Sleep Hygiene and Sleep Behavior in College Students

Johanna Schmickler, Rebecca Robbins, Pallas Snider Ziporyn, Stuart Quan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: sleep hygiene; sleep behavior; college students; sleep education program

Online: 6 March 2024 (04:49:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0879.v1

Neurodegeneration in Cognitive Impairment and Mood Dis-orders for Experimental, Clinical and Translational Neuropsy-chiatry

Simone Battaglia, Alessio Avenanti, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’ s disease;
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity

Online: 16 February 2024 (05:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0250.v1

Human Activity Recognition in a Free-Living Environment Using an Ear-Worn Motion Sensor

Lukas Boborzi, Julian Decker, Razieh Rezaei, Roman Schniepp, Max Wuehr

Subject: Computer Science And Mathematics, Signal Processing Keywords: human activity recognition; inertial sensor; ear; in-ear sensing; vital sign monitoring; wearables; machine learning; deep learning

Online: 3 April 2024 (11:06:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0259.v1

From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychosis; Parkinson's disease; antioxidants; genetic therapy; stroke; anxiety; migraine; epilepsy; aphasia; cardiovascular diseases; cognition

Online: 5 March 2024 (12:31:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2002.v1

Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review

Anees Bahji

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: comorbidity; substance use disorders; psychiatric disorders; treatment interventions; dual diagnosis

Online: 29 January 2024 (12:52:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0370.v1

CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric Disorders

Mariya Ivanovska, Zakee Abdi, Marianna Murdjeva, Danielle Macedo, Annabel Maes, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: eotaxin; immune marker; neuroinflammation; ageing; neuro-psychiatric disorder

Online: 30 January 2020 (14:42:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1091.v1

The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation

Bruno Roméo, Valentine Lestra, Catherine Martelli, Ammar Amirouche, Amine Benyamina, Nora Hamdani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; T. gondii; cannabis use; eosinophils counts

Online: 18 September 2023 (13:25:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0037.v1

The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre A. Geoffroy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: neuroplasticity; neuroprogression; psychiatric disorders; brain economy; severe mental illness; biomarkers

Online: 3 December 2018 (16:18:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0819.v1

Psychiatric Hospitalization for Psychopathological Disorders and Self-Injurious Behaviors in Italian Children and Adolescents during COVID-19

Maria Pontillo, Deny Menghini, Roberto Averna, Milena Labonia, Giulia Lazzaro, Maria Cristina Tata, Stefano Vicari

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 pandemic; children; adolescents; psychiatric hospitalization; mood disorders; non-suicidal self-injurious behaviors; suicidal ideation

Online: 12 October 2023 (15:43:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0043.v1

Symptom Severity Changes in Obsessive-Compulsive Patients during COVID-19 Pandemic Are Associated with Shorter Illness Duration and Benzodiazepine Use: Possible Evolutionary Advantage of a Psychiatric Disorder

Giordano D’Urso, Alfonso Magliacano, Marco Manzo, Mattia Vittorio Pomes, Carla Iuliano, Felice Iasevoli, Bernardo Dell'Osso, Andrea De Bartolomeis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: obsessive-compulsive disorder; COVID-19; clinical evolution; adaptive psychopathology; illness duration; anxious diathesis

Online: 1 March 2024 (17:40:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0775.v1

Prevalence of and Gender Differences in Psychiatric Disorders among Juvenile Detainees in South Korea: A Comparative Study

Bum-Sung Choi, Bongseog Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Juvenile detainees; psychiatric disorder; conduct disorder

Online: 12 October 2023 (05:38:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0682.v1

Psilocybin for Treating Psychiatric Disorders: Is it a Psychonaut Legend or a Promising Therapeutic Perspective?

Maurizio Coppola, Francesco Bevione, Raffaella Mondola

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psilocybin; psilocin; psychedelics; magic mushrooms

Online: 28 June 2021 (16:00:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0706.v1

Innate and Adaptive Regulation of Cognition

Rodrick Wallace

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: n/a; cognition; control thory; Fisher Zero phase transition; hierarchy; information theory; pathology; statistical models

Online: 12 March 2024 (13:48:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1589.v1

Investigation of the Possibility of Using Coal Flotation Waste in the Production of Agglomerate

IRSHEK Ibraev, Orazbike Ibraeva, Нурбек Айткенов, Kamalchan Sakipov K.E.

Subject: Metallurgy And Metallurgical Engineering, Engineering Keywords: flotation waste
dewatering
agglomeration
recycling
pelletizing

Online: 24 April 2024 (08:58:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0192.v1

Demands of Geometry on Color Vision

Dale Purves, Chidambaram Yegappan

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: trichromacy; opponency; color circularity; spectral images; unique colors; four-color map problem; perception

Online: 23 August 2016 (10:34:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0047.v2

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

Ashutosh Kumar, Pavan Kumar, Muneeb A. Faiq, Vikas Pareek, Khursheed Raza, Sankat Mochan, Pranav Prasoon, Vivek Sharma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: HPA axis; NGFs; psychiatric disorders; prevention of mental diseases; stress

Online: 4 December 2017 (07:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1025.v1

Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study

Luana Nosetti, Marco Zaffanello, Carolina Lombardi, Alessandra Gerosa, Giorgio Piacentini, Abramo Michele, Massimo Agosti

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: children; congenital heart disease; Electrocardiogram; Infant; long QT syndrome; neonatal screening; sudden infant death syndrome.

Online: 19 February 2024 (08:22:38 CET)

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(1) Background: Sudden Infant Death Syndrome (SIDS) represents unexplained and sudden deaths during the sleep of infants under one year of age, despite thorough investigation. Screening for prolonged QTc or Long QT Syndrome (LQTS) should be conducted on all newborns to reduce the incidence of SIDS. Neonatal electrocardiogram (ECG) could identify congenital heart defects (CHD) early, especially those not detected at birth. Infants with prolonged QT intervals typically undergo genetic analysis for Long QT Syndrome; (2) Methods: The study involved infants aged 20-40 days, born clinically healthy, with initial ECG screening. Infants with prenatal diagnoses or signs/symptoms of CHD identified immediately after birth, as well as those who underwent ECG or echocardiogram for other clinical or historical indications, were excluded from the study. The data were analyzed using SPSS version 22.0; (3) Results: Of the 42,200 infants involved, 2,245 were enrolled, with 39.9% being males. Subsequently, 164 children (37.8% males) with prolonged QT intervals underwent further diagnostic investigations. Genetic mutations were identified in 11 out of 18 tested children. The most common mutations were LQT1 (54.5%), LQT2 (36.4%), and LQT3 (1 patient). Medications used included propranolol (39.8%), nadolol (22.2%), inderal (11.1%), metoprolol (11.1%), and no treatment (16.7%). The most common abnormalities were focal right bundle branch block (54.5%), left axis deviation (9.2%), and nonspecific ventricular repolarization abnormalities (7.1%). Multiple anomalies were found in 0.47% of children with focal right bundle branch block. Structural abnormalities were associated with specific features in 267 patients (11.9%), primarily isolated patent foramen ovale (PFO) at 61.4%; (4) Conclusions: The screening has proven effective in early diagnosing Long QT Syndrome and other cardiac rhythm anomalies, with additional benefits in detecting mutations and/or QTc prolongations in family members. Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening.

Preprint ARTICLE | doi:10.20944/preprints202102.0607.v1

Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders its Relationship with the Body Mass Index

David Ruiz-Ramos, José Jaime Martínez-Magaña, Ana Rosa García, Isela Esther Juarez-Rojop, Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Emmanuel Sarmiento, María Lilia López-Narvaez, Nicolini Sanchez, Alma Delia Genis-Mendoza

Subject: Physical Sciences, Acoustics Keywords: Psychiatric comorbidity; Mexican population; Eating disorders

Online: 26 February 2021 (11:03:03 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202401.1338.v1

‘Belief-Consistent Information Processing’ vs. ‘Coherence-Based Reasoning’: Pragmatic Frameworks for Exposing Common Cognitive Biases in Intelligence Analysis

Matthew Barrows, George Ellison

Subject: Social Sciences, Decision Sciences Keywords: Cognitive bias
Intelligence analysis
Intelligence assessment
Confirmation bias
Decision-making
Information processing

Online: 18 January 2024 (09:47:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2052.v1

Investigating the Terrain of Class-incremental Continual Learning: A Brief Survey

Sahil Nokhwal, Nirman Kumar, Sajjan G. Shiva

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Continual learning;
Class-incremental learning;
Incremental learning;
Lifelong learning;
Learning on the fly;
Online learning;
Dynamic learning;
Learning with limited data;
Adaptive learning;
Sequential learning;
Learning from streaming data;
Learning from non-stationary distributions;
Never-ending learning;
Learning without forgetting;
Catastrophic forgetting;
Memory-aware learning

Online: 27 December 2023 (04:19:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201701.0057.v1

Phytomedicine in Joint Disorders

Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu

Subject: Biology And Life Sciences, Plant Sciences Keywords: osteoarthritis; rheumatoid arthritis; medicinal plants; herbs

Online: 11 January 2017 (07:56:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202312.0408.v1

100 Day Vaccine Development – An Alternative ApproachBoosters for Phase III Trialed Viral Family Vaccines

Robert Martin

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vaccines
100 Day Vaccine Development
COVID

Online: 6 December 2023 (10:47:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0105.v1

Epigenetic and Coping Mechanisms of Stress in Affective Disorders: a Scoping Review

Brenda-Cristiana Bernad, Mirela-Cleopatra Tomescu, Anghel Teodora, Diana Lungeanu, Virgil Enătescu, Elena Silvia Bernad, Vlad Nicoraș, Diana-Aurora Arnautu, Lavinia Hogea

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: epigenetic; coping; stress; affective disorders; DNA methylation; childhood trauma; stressor; depressive disorder; dietary deficiencies

Online: 1 April 2024 (14:54:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0775.v1

Classifying Objects in 3D Point Clouds Using Recurrent Neural Network: A GRU LSTM Hybrid Approach

Ramin Mousa, Mitra Khezli, Saba Hesaraki

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Point Cloud Classification; Virtual Reality; Hybrid Model; GRULSTM;
GRU; LSTM

Online: 13 March 2024 (10:00:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0306.v1

Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders

Šojat Dunja, Volarić Mile, Tanja Keškić, Nikola Volarić, Venija Cerovečki, Ljiljana Majnarić Trtica

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: gastrointestinal diseases; chronic diseases; cytokines; gastrointestinal microbiome; inflammation

Online: 6 March 2024 (10:57:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1187.v1

Toward Enhanced Plant Immunity: Unveiling the Role of Brassinosteroids in Abiotic and Biotic Stress Response

Barbara Sawicka*, Piotr Barbaś, Bernadetta Bienia, Dominika Skiba, Piotr Pszczółkowski, Barbara Krochmal-Marczak

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: plant hormones; gene expression; BR functions; antimicrobial actions; immunity mechanisms; plant stress

Online: 21 February 2024 (04:00:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0371.v1

Is Entropy a Force of Nature?

Martin Johnson

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: dark energy
cosmic background radiation
dark ages
large-scale structure of the Universe

Online: 7 February 2024 (03:37:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0104.v1

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Jongha Lee, Suhyuk Chi, and Moon-soo Lee

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: pediatric; depression; biomarker; BDNF; cytokines

Online: 5 July 2021 (14:48:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0994.v1

The Curious Role of PAI‐1 in Severe OSA

Tea Friščić, Edvard Galić, Domagoj Vidović, Petrana Brečić, Igor Alfirević

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plasminogen activator inhibitor-1; obstructive sleep apnea; continuous positive airway pressure; atherogenesis; fibrinolytic capacity

Online: 16 April 2024 (07:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1141.v1

From Mind to Plate to Pillow: Examining the Interplay of Mental Health, Eating Disorders, and Sleep Quality

Efstratios Christodoulou, Verra Markopoulou, Antonios E. Koutelidakis

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Sleep quality; insomnia; mental health; eating disorders; well-being

Online: 17 April 2024 (12:03:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1142.v1

The Impact of Psychological Health on Childhood Obesity: A Cross-Developmental Stage Analysis

Georgios Feretzakis, Athanasia Harokopou, Olga Fafoula, Athina Balaska, Antriana Koulountzou, Efstathia Katoikou, Athanasios Anastasiou, Georgios Zagkavieros, Ilias Dalainas, Georgios Gkritzelas

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Childhood Obesity; Psychological Well-being; Bioinformatics; Developmental Stages; Emotional Regulation; Social Dynamics; Adaptive Strategies; Obesity Interventions; Public Health; Pediatric Healthcare

Online: 20 February 2024 (11:59:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0962.v1

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Which Differences between Alcohol, Cannabis and Psychostimulants?

Martina Di Paolo, Antonia Calabrese, Guido Nosari, Valentina Ciappolino, Luisa Cirella, Alice Caldiroli, Enrico Capuzzi, Massimo Clerici, Massimiliano Buoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol; cannabis; clinical variables; peripheral biomarkers; psychostimulants; substance-induced psychotic disorder

Online: 19 February 2024 (14:34:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1680.v1

The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China

Ke Ma, Tianhang Zhou, Chengcheng Pu, Zhang Cheng, Xue Han, Lei Yang, Xin Yu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; weight gain; cognitive function; first episode; China

Online: 29 February 2024 (09:51:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0508.v1

MMD-MSD: A Multimodal Multisensory Dataset in Support of Musculoskeletal Disorders Research and Technology Development

Valentina Markova, Todor Ganchev, Silvia Filkova, Miroslav Markov

Subject: Computer Science And Mathematics, Other Keywords: multimodal dataset; musculoskeletal disorders prevention; computer-oriented working environment; performance evaluation; Stroop test; PPG; EDA; skin temperature; pictures; video; three-axis accelerometer

Online: 8 April 2024 (08:52:59 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.0594.v1

From CBT to Complex Therapy: A Novel Approach to the Treatment of Mental Disorders

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Complex Therapy; Psychiatry; Psychotehrapy; CBT; MindLAB Set; NegEnt

Online: 11 March 2024 (10:29:07 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0930.v1

Take It In: Novel Use of an Iron Bio-Absorbable Stent in Pediatric Pulmonary Stenosis

Christopher Scott, Jennifer R Maldonado, Daniel McLennan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: - ; ; Tetralogy of Fallot
- ; ; Bio-absorbable stent
- ; ; Pediatric cardiology
- ; ; Interventional cardiology

Online: 15 March 2024 (14:37:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0362.v1

SARS-CoV-2 Vaccines-Related Endocrine Disorders: An Updated Narrative Review

Avraham Ishay, Kira Oleinikov, Elena Chertok Shacham

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: COVID-19; COVID-19 vaccines; SARS-CoV-2 vaccine; endocrine adverse events; thyroid; pituitary; adrenal; diabetes; gonads

Online: 6 March 2024 (12:19:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1557.v1

Exploring Seizure Dynamics: A Computational Model of Epilepsy

Richard Murdoch Montgomery

Subject: Biophysics, Biology And Life Sciences Keywords: Epilepsy Dynamics
Computational Model

Online: 24 April 2024 (05:12:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1013.v3

Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges

Yogesh Chaudhari, Manisha Chaudhari, Abhijeet Puri, Mahesh Nemade

Subject: Pharmacy, Medicine And Pharmacology Keywords: computational pharmaceutics; AI; multi-scale modeling; quantum computing; drug discovery; blockchain frameworks

Online: 22 April 2024 (18:38:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0216.v1

Reduced Acute Ischemic Stroke-Induced Neural Inflammation Using Neural Stem Cell-Derived Extracellular Vesicles (AB126)

Samantha Spellicy, Emily Baker, Kelly Arscott, Sean Savitz, Steven L. Stice

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neural stem cell-derived extracellular vesicles, stroke, ; neuroinflammation

Online: 2 April 2024 (14:29:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0080.v1

Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis

Drozdstoy Stoyanov, Sevdalina Kandilarova, Katrin Aryutova, Rositsa Paunova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: multivariate linear method; validation; diagnosis; discriminative; signatures of disease; schizophrenia; depression

Online: 3 December 2020 (10:38:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1153.v1

Best Practices to Train Accurate Deep Learning Models: A General Methodology

Alberto Nogales, Ana Maitín, Álvaro J. García-Tejedor

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords:
Methodology; Artificial Intelligence; Deep Learning

Online: 20 February 2024 (14:35:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0778.v1

Collatz Conjecture Proof and General Equation

Kirk O. Hahn

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: collatz conjecture; proof; rules; dendritic pathway

Online: 11 April 2024 (07:07:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0204.v1

Professional Quality of Life, Job Satisfaction, and Intention to Leave Among Psychiatric Nurses

Shaher Hamaideh, Abdallah Abu Khait, Hanan Al-Modallal, Rami Masa'deh, Ayman Hamdan-Mansour, Mohammed AlBashtawy

Subject: Public Health And Healthcare, Nursing Keywords: ProQoL; job satisfaction; intention to leave; psychiatric nurses; Jordan

Online: 5 December 2023 (04:46:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0003.v1

A Comparative Analysis of Naïve Exosomes and Enhanced Exosomes with a Focus on the Treatment Potential in Ovarian Disorders

Mohammad Mousaei Ghasroldasht, Farzana Liakath Ali, Hang-Soo Park, Morteza Hadizadeh, Shao Huan Samuel Weng, Allen Huff, Somayeh Vafaei, Ayman Al-Hendy

Subject: Biology And Life Sciences, Other Keywords: enhanced exosomes; ovarian cancer; polycystic ovary syndrome; poor ovarian reserve; premature ovarian insufficiency

Online: 1 April 2024 (09:53:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0117.v2

Brain Stars Take the Lead during Critical Periods of Early Postnatal Brain Development: Relevance of Astrocytes in Health and Mental Disorders

Eugenia Vivi, Barbara Di Benedetto

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: astrocytes; critical period; synapse phagocytosis; sex differences; neuropsychiatric and neurodevelopmental disorders

Online: 13 March 2024 (07:22:10 CET)

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In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to the onset of severe pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology, molecular makeup and astrocyte-dependent processes in different affected brain regions in neurodevelopmental (ND) and neuropsychiatric (NP) disorders. Astrocytes proliferate, differentiate and mature during the critical period of early postnatal brain development, a time window of elevated glia-dependent regulation of a proper balance between synapse formation/elimination, which is pivotal in refining synaptic connectivity. Therefore, any intrinsic and/or extrinsic factors altering these processes during the critical period may result in an aberrant synaptic remodelling and onset of mental disorders. The peculiar bridging position of astrocytes between synaptic and vascular compartments further allows them to “compute” the brain state and consequently secrete factors in the bloodstream, which may serve as diagnostic biomarkers of distinct healthy or disease conditions.Here, we collect recent advancements regarding astrogenesis and astrocyte-mediated regulation of neuronal network remodelling during early postnatal critical periods of brain development, focusing on synapse elimination. We then propose alternative hypotheses for an involvement of aberrancies in these processes in the onset of ND and NP disorders. In light of the well-known differential prevalence of certain brain disorders between males and females, we also discuss putative sex-dependent influences on these neurodevelopmental events.From a translational perspective, understanding age- and sex-dependent astrocyte-specific molecular and functional changes may help to identify biomarkers of distinct cellular (dys)functions in health and disease, favouring the development of diagnostic tools or the selection of tailored treatment options for male/female patients.

Preprint ARTICLE | doi:10.20944/preprints202404.1093.v1

Raising Awareness of the Importance of Early Diagnosis of Children with Autism Spectrum Disorders (ASD)

Adrian-Nicolae DAN, Nina Stănescu

Subject: Social Sciences, Sociology Keywords: Autism Spectrum Disorders (ASD); early diagnosis / screening; early intervention; social services

Online: 17 April 2024 (14:03:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0353.v1

Chromothripsis and DNA-repair Disorders

Lusine Nazaryan-Petersen, Victoria Alexandra Bjerregaard, Finn Cilius Nielsen, Niels Tommerup, Zeynep Tümer

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chromothripsis; structural variants; DNA-repair; DNA-repair disorders; DNA-double strand breaks (DSBs); ataxia telangiectasia mutated (ATM); ataxia-telangiectasia and Rad3-related (ATR); TP53; micronuclei; chromosome pulverization.

Online: 29 January 2020 (11:58:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1550.v1

Bud Multiplication and In Vitro Callogenesis of Sechium compositum (Donn. sm.) C. Jeffrey from Stem and Leaf Explants

Riviello-Flores María de la Luz, Castillo-Martínez Carlos Román, Ruiz-Posadas Lucero del Mar, Cadena-Iñiguez Jorge, Soto-Hernández Ramón Marcos, Arévalo-Galarza Ma. de Lourdes, Castillo-Juárez Israel

Subject: Biology And Life Sciences, Horticulture Keywords: agrobiodiversity; in vitro multiplication; Cucurbitaceae; underutilized species; Sechium (P. Br.)

Online: 20 December 2023 (13:02:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1337.v1

Ana Pjevac, Teodora Safiye, Mirjana Jovanovic

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: internet addiction, adolescents, temperament, online, IAT, TEMPS

Online: 23 February 2024 (09:10:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0951.v1

Sociodemographic and Clinical Correlates including Psychiatric Comorbidities in Clinical Population of Irritable Bowel Syndrome

Ankita Saroj, Adarsh Tripathi, Sumit Rungta, Sujita Kumar Kar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Irritable bowel Syndrome; Psychiatric comorbidities; Somatic symptoms; Anxiety; Stress

Online: 18 March 2024 (09:20:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0155.v1

Prevalence & Psychiatric Correlates of Illicit Substance Use in UK Undergraduate students

Holly Foster, Jodie Stevenson, Umair Akram

Subject: Social Sciences, Behavior Sciences Keywords: Sleep; Substance Use; Insomnia; Anxiety; Depression; Students; Stress

Online: 9 February 2023 (06:03:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0484.v1

Synthesized Ligands of Amino Phenyl TIPS-pentacene and Tetraphenylporphyrin for Singlet Fission

Shaimaa Abdalbaqi

Subject: Physical Sciences, Applied Physics Keywords: semiconductor nanocrystals, PbS nanocrystals, coupled organic-inorganic nanostructures,
ligands

Online: 7 December 2023 (16:31:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0448.v1

The Impact of Event Scale – Revised: Examining its cutoff scores among Arab psychiatric patients and healthy adults within the context of COVID-19 as a collective traumatic event

Amira M. Ali, Saeed Abdullah Al-Dossary, Abdulaziz Mofdy Almarwani, Maha Atout, Rasmieh Al-Amer, And Abdulmajeed A. Alkhamees

Subject: Social Sciences, Psychology Keywords: Impact of Event Scale-Revised (IES-R)/post-traumatic stress disorder (PTSD); cutoff point/cutoff score; psychiatric patients/the general public/healthy adults; psychometric evaluation/criterion validity; Coronavirus Disease-19/COVID-19; Arabic version/Arab/Saudi Arabia

Online: 25 January 2023 (05:02:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0024.v1

Identification of One BOCR Mutation and Five NF1 Mutations in Male Patients with Neurofibromatosis Type 1 and Congenital Pseudarthrosis of the Tibia

Zhifan Zhou, Yong Zeng, Xinchun Wu, Fei Li, Xiaoyan Liu, Lu Zhou, Lihua Hou, Silong Sun, Lu Shen, Zhangyuan Lin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurofibromatosis type 1; congenital pseudarthrosis of the tibia; whole-exome sequencing; targeted sequencing; BCOR

Online: 7 September 2016 (11:19:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0781.v1

The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

Priscila Oliveira Barbosa, Jose E. Tanus-Santos, Ricardo de Carvalho Cavalli, Tore Bengtsson, Marcelo Freitas Montenegro, Valeria Cristina Sandrim

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Endothelial cell; pregnancy; nitric oxide; nitrate; oxidative stress; pre-eclampsia.

Online: 11 April 2024 (10:29:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0099.v1

The Equations and Their Effects

carlos eduardo ramos cardoso cardoso

Subject: Physical Sciences, Mathematical Physics Keywords: multiplication and addition equations; division equations; subtraction equations;
physical concepts

Online: 4 March 2024 (10:36:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0397.v1

Probiotics in Autoimmune and Inflammatory Disorders

Yuying Liu, Jane J. Alookaran, J. Marc Rhoads

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: lactobacilli; bifidobacilli; arthritis; inflammatory bowel; microbiome; metabolomics; aryl hydrocarbon reductase; adenosine; histamine; short chain fatty acid

Online: 20 September 2018 (05:12:00 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0800.v1

Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models

Masaru Tanaka, Ágnes Szabó, László Vécsei, Lydia Giménez-Llort

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; Parkinson's disease; multiple sclerosis; depressive disorder; anxiety disorder; bipolar disorder; electric stimulation; translational research

Online: 12 October 2023 (08:38:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1682.v1

Online Reviews Classification and Summarization: A Comprehensive Analysis

Saima Abdullah, Humaira Ashraf, NZ Jhanjhi

Subject: Computer Science And Mathematics, Computer Science Keywords: online reviews, classification, summarization, machine learning, systematic literature ;
review.

Online: 22 December 2023 (07:01:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0452.v1

The Impact of Oxidative Stress on the Epigenetics of Fetal Alcohol Spectrum Disorders

Sergio Terracina, Luigi Tarani, Mauro Ceccanti, Mario Vitali, Silvia Francati, Marco Lucarelli, Sabrina Venditti, Loredana Verdone, Giampiero Ferraguti, Marco Fiore

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: FASD; Epigenetics; Oxidative Stress; Antioxidants; Alcohol

Online: 7 March 2024 (12:06:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0447.v1

Application of Mass Multivariate Analysis on Neuroimaging Data Sets in Psychiatric Diagnostics

Rositsa Paunova, Sevdalina Kandilarova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif, Drozdstoy Stoyanov

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mass multivariate analysis; neuroimaging, depression, schizophrenia

Online: 31 January 2022 (11:07:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0311.v1

Fiber Structure and Stability Theorems for Symmetry Breaking Transitions

Eve Bodnia

Subject: Physical Sciences, Mathematical Physics Keywords: Fiber bundle, phase transitions, Lie groups, homotopy,
fundamental group, Stability Theorem, Stability Lemma, Fiber Structure
Theorem, superfluid Helium

Online: 6 March 2024 (10:15:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1708.v1

Modelling Lysosomal Storage Disorders in an innovative way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidoses Type II Patients

Sofia Carvalho, Juliana Inês Santos, Luciana Moreira, Ana Joana Duarte, Paulo Gaspar, Hugo Rocha, Marisa Encarnação, Diogo Ribeiro, Matilde Barbosa Almeida, Mariana Gonçalves, Hugo David, Liliana Matos, Olga Amaral, Luísa Diogo, Sara Ferreira, Constança Santos, Esmeralda Martins, Maria João Prata, Luís Pereira de Almeida, Sandra Alves, Maria Francisca Coutinho

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mucopolysaccharidosis type II; Disease Modelling; in vitro models; induced Pluripotent Stem Cells (iPSCs); Dental Pulp Stem Cells (DPSCs); SHED: Stem cells from Human Exfoliated Deciduous teeth (SHEDs)

Online: 29 February 2024 (13:03:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0601.v1

Influence of Social Media Usage, Academic Performance and Working Memory among Undergraduate Students

Nnaemeka Emmanuel Mgbedo, Marbyen Elma Musa, Pragati Chhikara, Rupam Chaturvedi, Nikita Vyas, Nana Zavradashvili

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: social media; academic performance; working memory; students; addiction

Online: 9 February 2024 (15:59:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1265.v1

The Influence of Gender on the Psychiatric Comorbidity of Treated Danish Patients With and Without Alcoholism

Elizabeth C Penick, Waheeda A. Hossain, Wendy Madarasz, Ann M Manzardo, Joachim Knop, Erik L Mortensen, William F Gabrielli

Subject: Health Policy And Services, Public Health And Healthcare Keywords: Alcohol use disorder; Gender; Psychiatric comorbidity

Online: 19 April 2024 (09:56:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0348.v2

Functional Myelin in Cognition and Neurodevelopmental Disorders

Hasni Khelfaoui, Cristobal Ibaceta-Gonzalez, Maria Cecilia Angulo

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: myelin; cognition; oligodendrocytes; OPCs; development; schizophrenia; autism spectrum disorder; brain oscillations

Online: 12 December 2023 (10:53:53 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0117.v1

Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders

Douglas A Gibson, Ioannis Simitsidellis, Frances Collins, Philippa TK Saunders

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: decidualisation; oestradiol; aromatase; testosterone; DHEA; endometriosis; endometrial cancer; sulfatase

Online: 7 October 2018 (10:03:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0463.v1

Graphene Oxide 2D Films for Integrated Thermo-Optic Devices

David Moss

Subject: Physical Sciences, Optics And Photonics Keywords: Integrated photonics; 2D material; thermo-optics

Online: 8 April 2024 (06:02:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1075.v4

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Rima Obeid, Emmanuel Andrès, Richard Češka, Babak Hooshmand, Rosa-Maria Guéant-Rodriguez, Gabriel Ioan Prada, Jarosław Sławek, Latchezar Traykov, Binh Van Ta, Tamás Várkonyi, Karlheinz Reiners

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diagnosis; neuropathy; cognitive decline; anemia; treatment; vitamin B12 deficiency

Online: 9 April 2024 (10:26:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0410.v1

Existence and Limit Behavior of Constraint Minimizers for a Varying Nonlocal Kirchhoff Type Energy Functional

Xincai Zhu, Hanxiao Wu

Subject: Computer Science And Mathematics, Analysis Keywords: Kirchhoff type energy functional; constraint minimizer; limit behavior;
varying nonlocal term

Online: 7 February 2024 (06:30:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1477.v1

Advancing Skarn Iron Ore Detection Through Multispectral Image Fusion and 3D Convolutional Neural Networks (3D-CNN)

Jabir Abubakar, Zhaochong Zhang, Zhiguo Cheng, Fojun Yao, Abdoul-Aziz BIO SIDI D. BOUKO

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: Aster bands; Band ratio (BR) images; Principal Component (PC) bands; 3D-CNN

Online: 23 April 2024 (09:44:59 CEST)

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This study explores novel techniques to improve the detection accuracy of skarn iron deposits using advanced image processing methodologies. Leveraging the capabilities of Aster image, Band Ratio (BR) images, and Principal Component Analysis (PCA), alongside the power of 3D Convolutional Neural Networks (3D-CNN), the research aims to enhance the precision and efficiency of ore detection in complex geological environments. The proposed method employs a specific 3D-CNN architecture, accepting input as a 7×7×C image patch, where C represents the combined number of selected Aster image bands, Principal Component (PC) bands, and computed BR images. To evaluate the accuracy of the proposed method, five distinct image bands combinations, including the proposed bands combination, were tested and evaluated based on the overall accuracy (OA), average accuracy (AA), and kappa coefficient. The results demonstrated that while the incorporation of BR images alongside Aster bands initially seemed promising, it introduced significant confusion in certain classifications, leading to unexpected mis-classification rates. Surprisingly, utilizing solely Aster bands as input parameters yielded higher accuracy rates (OA= 93.13%, AA = 91.96%, Kappa = 90.91%) compared to scenarios involving the integration with band ratios (OA = 87.02%, AA = 79.15, and Kappa = 82.60%) or the integration of BR images to PC bands (OA= 87.78%, AA = 82.39%, Kappa = 83.81%). However, the amalgamation of Aster bands with selected PC bands showed slight improvements in accuracy (OA= 94.65%, AA = 92.93%, Kappa = 93.45%), although challenges in accurately classifying certain features persisted. Ultimately, the proposed combination of Aster bands, PC bands, and BR images (proposed bands combination) presented the most visually appealing and statistically accurate results (OA = 96.95%, AA= 94.87%, and Kappa = 95.93%), effectively addressing misclassifications observed in the other combinations. These findings underscore the synergistic contributions of each of the Aster bands, PC bands, and BR images, with Aster bands proving pivotal for optimal skarn classification, PC bands enhancing intrusions classification accuracy, and BR images strengthening wall rock classification accuracy. In conclusion, the proposed combination of input image bands emerges as a robust and comprehensive methodology, demonstrating unparalleled accuracy in the remote sensing detection of skarn iron minerals.

Preprint REVIEW | doi:10.20944/preprints202306.1835.v1

Dental implants and bleeding disorders: review and clinical indications

Christian Bacci, Claudia Schiazzano, Ezio Zanon, Edoardo Stellini, Luca Sbricoli

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental implants; bleeding disorders; haemophilia; von Willebrand disease.

Online: 26 June 2023 (16:21:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0296.v1

Aterosclerosis, Cardiovascular Disorders And Covid-19: Comorbid Pathogenesis

Yulia A Makarova, Varvara A Ryabkova, Vladimir V Salukhov, Boris V Sagun, Aleksandr E Korovin, Leonid P Churilov

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: atherosclerosis; COVID-19; inflammation; cardiovascular system; cytokines; endothelium; lipoproteins; renin-angiotensin system; atheroma; autoimmunity; vasa vasorum.

Online: 16 December 2022 (06:32:21 CET)

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Preprint REVIEW | doi:10.20944/preprints201904.0007.v1

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Sunil Kumar, Muhammad Umer Ashraf, Yideul Jeong, Yong-Soo Bae

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: dendritic cells; Th2 immunity; genetic factors; environmental factors; Th2 disorders; therapeutic approaches

Online: 1 April 2019 (10:14:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0171.v1

Microbiota-Gut-Brain-Axis and Autism Spectrum Disorders

Piranavie Srikantha, M. Hasan Mohajeri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Autism, ASD, microbiota, gut-brain-axis, microbiota-gut-brain-axis, therapy

Online: 7 November 2018 (14:45:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0593.v1

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Chelsea Matisz, Aaron Gruber

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: gut inflammation; neuroinflammation; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; irritable bowel syndrome; Celiac disease; functional dyspepsia; anterior cingulate cortex; microglia; sympathetic nervous system; mood disorders; depression; anxiety; cognition

Online: 25 September 2020 (03:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1298.v1

Analysis of Attitudes and Practices towards the Influenza Vaccine in High-Risk Adults in Poland

Dorota Kopciuch, Karolina Hoffmann, Krzysztof Kus, Agnieszka Koligat-Seitz, Piotr Ratajczak, Elżbieta Nowakowska, Anna Paczkowska

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: vaccines; influenza; high-risk groups; attitudes; practice

Online: 23 February 2024 (08:30:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0878.v1

Insights into Pediatric Sleep Disordered Breathing: Exploring Risk Factors, Surgical Interventions, and Long-Term Neuropsychological Outcomes

Marco Zaffanello, Angelo Pietrobelli, Leonardo Zoccante, Luca Sacchetto, Luana Nosetti, Michele Piazza, Giorgio Piacentini

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adenoidectomy; adenotonsillectomy; breastfeeding; children; obstructive sleep apnea; quality of life; Pediatric Sleep Questionnaire; sleep-disordered breathing

Online: 16 February 2024 (07:41:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0138.v1

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive, and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Victor Vasilyevich Dyakin, Nika Victorovna Dyakina-Fagnano, Laura Beth McIntire, Vladimir Nikolaevich Uversky

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: spontaneous; non-enzymatic; post translational modifications; racemization; biological clock; natural selection; allostatic load; psychological aging; psychological stress; stress response sys-tem; phase transitions.

Online: 8 November 2021 (13:08:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1212.v2

Intrinsic Geometric Structure of Subcartesian Spaces

Richard Cushman, Jedrzej Sniatycki

Subject: Computer Science And Mathematics, Other Keywords: subcartesian differential space
orbits of family of vector fields

Online: 27 November 2023 (05:26:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2041.v1

Multimodal Effect of Na⁺/K⁺ ATPase Blocker Ouabain on the Tumor Microenvironment and Malignant Cells

Octavia-Oana Harich, Oana-Isabella Gavriliuc, Valentin-Laurentiu Ordodi, Alexandru Tirziu, Virgil Paunescu, Carmen Panaitescu, Maria-Florina Bojin

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Ouabain; Na+/K+ ATPase; SK-BR-3 tumor cells; TAFs; MSC; molecular target

Online: 30 May 2023 (04:33:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2021.v1

Innovation-based Strategic Roadmap for Economic Sustainability and Diversity in Hydrocarbon-Driven Economies: The Qatar Perspective

Ahmed Al-Sulaiti, Abdel Magid Hamouda, Hussain Al-Yafei, Galal Abdella

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: innovation ecosystems; economic sustainability; hydrocarbon-based economies;
economic diversification; qualitative approach ;

Online: 29 January 2024 (12:30:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0285.v1

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities

Michael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Ana Paula Michelin, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Andre Carvalho, Sunee Sirivichayakul, Decio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: oxidative stress; neuroimmunomodulation; major depression; inflammation; neurotoxicity; schizophrenia

Online: 24 January 2020 (14:46:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0297.v1

The Impact of Foehn Wind on Mental Distress among Patients in a Swiss Psychiatric Hospital

Christian A. Mikutta, Charlotte Pervilhac, Hansjörg Znoj, Andrea Federspiel, Thomas J Müller

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: foehn wind; psychopathology; BSCL; mental health; weather; meteorological factors; climate change

Online: 17 August 2022 (04:04:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1258.v1

Understanding Drug-Induced Movement Disorders: Causes, Symptoms, and Treatment

Eduardo R. Santos

Subject: Medicine And Pharmacology, Internal Medicine Keywords: DIMD; DIP; Review; parkinsonism; DID; dyskinesia; tardive syndromes

Online: 22 February 2024 (07:49:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0182.v1

Personality Disorders and Traits of ABC Clusters in Fibromyalgia

Dmitry V. Romanov, Tatiana I. Nasonova, Aleksey I. Isaikin, Olga V. Filileeva, Andrey M. Sheyanov, Polina G. Iuzbashian, Evgenia I. Voronova, Vladimir A. Parfenov

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: fibromyalgia, personality disorders, Axis II, personality disorders clusters, personality traits, borderline, schizotypal, schizoid, avoidant

Online: 4 October 2023 (07:51:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0808.v1

Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders

Fabiola De Marchi, Lea Vidatic, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, Boris Rogelj, Vladimira Vuletic, Rajka M. Liscic, Jason R. Cannon, Emanuele Buratti, Letizia Mazzini, Ivana Munitic, Silva Hecimovic

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; Parkinson’s disease; Niemann-Pick type C disease; neurodegeneration; neuroinflammation; immunomodulatory therapies; rare diseases

Online: 13 September 2023 (07:33:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0465.v1

Epigenetics and the Environmental Landscape of Autism Spectrum Disorders

German Torres, Mervat Mourad, Saba Iqbal, Emmanuel Moses-Fynn, Ashani Pandita, Shriya S. Siddhartha, Riya A. Sood, Kavya Srinivasan, Riya T. Subbaiah, Alisha Tiwari, Joerg R. Leheste

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: lleles; Brain; Disease; Genes; Gastrointestinal Tract; Mutations; Epigenetics; Evolution; Phenotypes

Online: 4 August 2023 (19:17:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0487.v1

Anxiety Disorders: Sex Differences in Serotonin and Tryptophan Metabolism

Tanya Songtachalert, Chutima Roomruangwong, Andre F. Carvalho, Michel Bourin, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: sex; anxiety disorders; 5-HT; tryptophan; immune system; inflammation

Online: 29 August 2018 (08:58:26 CEST)

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Anxiety disorders manifest in women more than in men by almost twofold. This narrative review aims to summarize the sex-related biological factors, which underpin anxiety, focusing on the interactions of sex and tryptophan/serotonin with anxiety.A literature search was conducted using Google Scholar, PubMed/MEDLINE, Scopus, and EMBASE databases from inception until December 31, 2017. This review shows that sex may interact with many serotonin functions thereby modulating anxiety, including 5-HT1A and 5-HT2C receptors, 5-HT transporter and central 5-HT concentrations and metabolism. Sex-steroids modulate the expression of serotonin transporter genes, creating a difference in serotonin availability. Sex and estrous cycle phases lead to varying anxiety responses to tryptophan depletion. Testosterone, progesterone and estrogen are important factors in mediating sex differences in serotonin responses to anxiety-generating behavioral tests. At prenatal levels, there are sex-related differences in the reciprocal relationships between serotonin and the HPA-axis, which modulate anxiety-like behaviors. Activated immune-inflammatory pathways induce indoleamine-2,3-dioxynease (IDO) and the tryptophan catabolite (TRYCAT) pathway thereby increasing tryptophan degradation and increasing the production of TRYCATs including kynurenine and quinolinic acid, which may create an overall anxiogenic effect. The effects of immune activation on IDO are significantly more pronounced in women than men and therefore females may show increased levels of anxiogenic TRYCAT following immune challenge. Aberrations in the IDO-activated TRYCAT pathway are found in pregnant females and parturients and are associated with increased anxiety levels in the postnatal period. The results of this review underscore the necessity of studying the associations between serotonin and anxiety in both sexes taking into account the effects of immune activation on IDO and production of anxiogenic TRYCATs. Future anxiety research should focus on the interactions between serotonin/tryptophan and sex, sex hormones, the menstrual cycle, pregnancy, the HPA axis and the immune system through production of anxiogenic TRYCATs.

Preprint ARTICLE | doi:10.20944/preprints202402.1597.v1

Bidirectional Two-Sample Mendelian Randomization Analysis Identifies Causal Associations between Gut Microbiome and Sleep-Related Traits

Mingxia Zhai, Weichen Song, Zhe Liu, Wenxiang Cai, Guanning Lin

Subject: Biology And Life Sciences, Other Keywords: Gut Microbiome; Bacterial Pathways; Sleep-related Traits; Mendelian Randomization; Causal Relationship

Online: 28 February 2024 (10:53:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0195.v1

Testing the Reliability and Construct Validity of Short-Term Assessment of Risk and Treatability (START) in Non-Western Forensic Psychiatric Inpatients

Weeerapong Sanmontree, Peera Wongupparaj

Subject: Social Sciences, Psychology Keywords: Thai START; Forensic psychiatric inpatients; Confirmatory factor analysis with ordinal data; Violence risk assessment; forensic psychology; Psychometrics

Online: 13 January 2022 (15:57:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2001.v1

Comparison Between Post-Fire Analysis and Pre-Fire Risk Assessment Produced from Various Geospatial Data

Cumhur Güngöroğlu, İrem İsmailoğlu, Bekir Kapukaya, Orkan Ozcan, Mustafa Yanalak, Nebiye Musaoğlu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: forest fire; remote sensing; risk assessment; burnt analysis; fuzzy analytic hierarchy
process (FAHP)

Online: 26 December 2023 (14:31:29 CET)

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Abstract: Wildfires in forest ecosystems exert substantial ecological, economic, and social impacts. The effectiveness of fire management hinges on precise pre‐fire risk assessments to inform mitigation efforts. This study aims to investigate the relationship between predictions from pre‐fire risk assessments and outcomes observed through post‐fire burn severity analyses. In this study, forest fire risk was assessed with the Fuzzy Analytical Hierarchy Process, in which fire behavior factors were used as input. The degree of burn was determined using the Random Forest method using 11519 training points and 400 test points on Sentinel‐2 satellite images in three different classes. According to the results obtained from 266 selected test points located within the forest boundaries, all primary factors showed an increased effect in areas with high burn severity. Climate, in particular, emerged as the most influential factor, accounting for 52% of the overall impact. However, in cases of high fire severity, climate proved to be the most effective risk factor, ac‐counting for 67%. It followed by topography with 50% accuracy at high fire intensity. In the risk assessment is based on the FAHP method, climate was assigned the highest weight value among other factors with 32.2%. Topography emerged as the second most effective risk factor with 27 %. To evaluate the results more comprehensively both visually and statistically, two regions with different stand canopy characteristics were selected within the study area. While high burn severity had the highest accuracy in Case 1 area, moderate burn severity had the highest in Case 2 area. During the days when the fire continued, the direction of spread was obtained from MODIS images. In this way, the fire severity depending on the direction of fire progression was also interpreted. Through an analysis of various case studies and existing literature, the research underscores both the strengths and limitations inherent in predicting forest fire behavior‐based pre‐fire risk assessments. Furthermore, it emphasizes the necessity of continuous improvement to increase the success of forest fire management.

Preprint REVIEW | doi:10.20944/preprints201805.0264.v1

Endoplasmic Reticulum Stress in Metabolic Disorders

Rose Ghemrawi, Shyue-Fang Battaglia-Hsu, Carole Arnold

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: endoplasmic reticulum stress; metabolic disorders; unfolded protein response; inflammation; lipotoxicity; glucotoxicity; therapy

Online: 21 May 2018 (08:09:59 CEST)

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