Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Vaccines-Related Endocrine Disorders: An Updated Narrative Review

Version 1 : Received: 26 February 2024 / Approved: 6 March 2024 / Online: 6 March 2024 (12:19:04 CET)

A peer-reviewed article of this Preprint also exists.

Ishay, A.; Oleinikov, K.; Chertok Shacham, E. SARS-CoV-2-Vaccine-Related Endocrine Disorders: An Updated Narrative Review. Vaccines 2024, 12, 750, doi:10.3390/vaccines12070750. Ishay, A.; Oleinikov, K.; Chertok Shacham, E. SARS-CoV-2-Vaccine-Related Endocrine Disorders: An Updated Narrative Review. Vaccines 2024, 12, 750, doi:10.3390/vaccines12070750.

Abstract

Abstract: The emergence of the COVID-19 pandemic has led to the rapid and worldwide devel-opment and investigation of multiple vaccines. While most side effects of these vaccines are mild and transient, potentially severe adverse events may occur and involve the endocrine system. This narrative review aims to explore the current knowledge on potential endocrine adverse effects following COVID-19 vaccination, with thyroid disorders being the most common. Data about pi-tuitary, adrenal, diabetes, and gonadal events will also be reviewed. This review also provides a comprehensive understanding of the pathogenesis of endocrine disorders associated with SARS-CoV-2 vaccines. A PubMed/MEDLINE, Embase database (Elsevier), and Google Scholar research were performed. Case reports case series, original studies, and reviews written in English and published online up to 31 August 2023 were selected and reviewed. Data on endocrine adverse events of SARS-CoV-2 vaccines is accumulating. However, their causal relationship with COVID-19 vaccines is not strong enough to make a definite conclusion, and further studies are needed to clarify the pathogenesis mechanisms of endocrine disorders linked to COVID-19 vac-cines.

Keywords

COVID-19; COVID-19 vaccines; SARS-CoV-2 vaccine; endocrine adverse events; thyroid; pituitary; adrenal; diabetes; gonads

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

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