Version 1
: Received: 27 February 2024 / Approved: 28 February 2024 / Online: 28 February 2024 (10:53:33 CET)
How to cite:
Zhai, M.; Song, W.; Liu, Z.; Cai, W.; Lin, G. Bidirectional Two-Sample Mendelian Randomization Analysis Identifies Causal Associations between Gut Microbiome and Sleep-Related Traits. Preprints2024, 2024021597. https://doi.org/10.20944/preprints202402.1597.v1
Zhai, M.; Song, W.; Liu, Z.; Cai, W.; Lin, G. Bidirectional Two-Sample Mendelian Randomization Analysis Identifies Causal Associations between Gut Microbiome and Sleep-Related Traits. Preprints 2024, 2024021597. https://doi.org/10.20944/preprints202402.1597.v1
Zhai, M.; Song, W.; Liu, Z.; Cai, W.; Lin, G. Bidirectional Two-Sample Mendelian Randomization Analysis Identifies Causal Associations between Gut Microbiome and Sleep-Related Traits. Preprints2024, 2024021597. https://doi.org/10.20944/preprints202402.1597.v1
APA Style
Zhai, M., Song, W., Liu, Z., Cai, W., & Lin, G. (2024). Bidirectional Two-Sample Mendelian Randomization Analysis Identifies Causal Associations between Gut Microbiome and Sleep-Related Traits. Preprints. https://doi.org/10.20944/preprints202402.1597.v1
Chicago/Turabian Style
Zhai, M., Wenxiang Cai and Guanning Lin. 2024 "Bidirectional Two-Sample Mendelian Randomization Analysis Identifies Causal Associations between Gut Microbiome and Sleep-Related Traits" Preprints. https://doi.org/10.20944/preprints202402.1597.v1
Abstract
Recent research has highlighted associations between sleep and microbial taxa and pathways. However, the causal effect of these associations remains unknown. To investigate this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis using summary statistics of genome-wide association studies (GWAS) from 412 gut microbiome traits (N = 7,738) and GWAS studies from seven sleep-associated traits (N = 345,552 to 386577). We employed multiple MR methods to assess causality, with Inverse Variance Weighted (IVW) as the primary method. We further applied Cochran’s Q statistical analysis, MR-Egger intercept, and MR-PRESSO for heterogeneity and pleiotropy assessment, alongside a Bonferroni correction ((P
Keywords
Gut Microbiome; Bacterial Pathways; Sleep-related Traits; Mendelian Randomization; Causal Relationship
Subject
Biology and Life Sciences, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
