Preprint Review Version 1 This version is not peer-reviewed

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Version 1 : Received: 30 March 2019 / Approved: 1 April 2019 / Online: 1 April 2019 (10:14:44 CEST)

A peer-reviewed article of this Preprint also exists.

Kumar, S.; Jeong, Y.; Ashraf, M.U.; Bae, Y.-S. Dendritic Cell-Mediated Th2 Immunity and Immune Disorders. Int. J. Mol. Sci. 2019, 20, 2159. Kumar, S.; Jeong, Y.; Ashraf, M.U.; Bae, Y.-S. Dendritic Cell-Mediated Th2 Immunity and Immune Disorders. Int. J. Mol. Sci. 2019, 20, 2159.

Journal reference: Int. J. Mol. Sci. 2019, 20, 2159
DOI: 10.3390/ijms20092159

Abstract

Dendritic cells (DCs) are the professional antigen-presenting cells that recognize and present antigens to naïve T cells to induce antigen-specific adaptive immunity. Among the T-cell subsets, T helper type 2 (Th2) cells produce the humoral immune responses required for protection against helminthic disease by activating B cells. DCs induce a Th2 immune response at a certain immune environment. Basophil, eosinophil, mast cells, and type 2 innate lymphoid cells also induce Th2 immunity. However, in the case of DCs, controversy remains regarding which subsets of DCs induce Th2 immunity, which genes in DCs are directly or indirectly involved in inducing Th2 immunity, and the detailed mechanisms underlying induction, regulation, or maintenance of the DC-mediated Th2 immunity against allergic environments and parasite infection. A recent study has shown that a genetic defect in DCs causes an enhanced Th2 immunity leading to a severe atopic dermatitis. We summarize the Th2 immune-inducing DC subsets, the genetic and environmental factors which involved in DC-mediated Th2 immunity, and current therapeutic approaches for Th2-mediated immune disorders. This review is to provide an improved understanding of DC-mediated Th2 immunity and Th1/Th2 immune balancing, leading to control over their adverse consequences.

Subject Areas

dendritic cells; Th2 immunity; genetic factors; environmental factors; Th2 disorders; therapeutic approaches

Comments (1)

Comment 1
Received: 2 April 2019
Commenter: Amit Kumar
The commenter has declared there is no conflict of interests.
Comment: An outstanding review that summarizes the epi- and transcriptomic circuits responsible for the DC mediated Th2 immunity. However, I would like to have a figure that describes these circuits inDC. All the best.
Amit
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