Andrade, A.; Brennecke, A.; Mallat, S.; Brown, J.; Gomez-Rivadeneira, J.; Czepiel, N.; Londrigan, L. Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders. Preprints2019, 2019060192. https://doi.org/10.20944/preprints201906.0192.v1
APA Style
Andrade, A., Brennecke, A., Mallat, S., Brown, J., Gomez-Rivadeneira, J., Czepiel, N., & Londrigan, L. (2019). Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders. Preprints. https://doi.org/10.20944/preprints201906.0192.v1
Chicago/Turabian Style
Andrade, A., Natalie Czepiel and Laura Londrigan. 2019 "Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders" Preprints. https://doi.org/10.20944/preprints201906.0192.v1
Abstract
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has always been observed that psychiatric disorders have a genetic component, however new methods to sequence full genomes of large cohorts have identified with high precision genetic risk loci for these conditions. Psychiatric disorders include, but are not limited to, bipolar disorder, schizophrenia, autism spectrum disorder, anxiety disorders, major depressive disorder, and attention-deficit and hyperactivity disorder. Several risk loci for psychiatric disorders fall within genes that encode for voltage-gated calcium channels (CaVs). Calcium entering through CaVs is key for multiple neuronal processes. In this review, we will summarize recent findings that link CaVs and their auxiliary subunits to psychiatric disorders. First, we will provide a general overview of CaVs structure, classification, function, expression and pharmacology. Next, we will summarize tools and databases to study risk loci associated with psychiatric disorders. We will examine functional studies of risk variations in CaV genes when available. We will review pharmacological evidence of the use of CaV modulators to treat psychiatric disorders. Our review will be of interest for those studying pathophysiological aspects of CaVs.
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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