Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202012.0181.v2

Metamaterials Demonstrating Negative Thermal Capacity

Edward Bormashenko, Evgeny Shulzinger

Subject: Chemistry And Materials Science, Biomaterials Keywords: metamaterials; negative effective mass; negative density; negative thermal capacity; resonance.

Online: 26 January 2021 (11:36:03 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202203.0357.v1

Negative Electrical Conductivity Metamaterials

Edward Bormashenko

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: metamaterial; negative electrical conductivity; negative mass; Drude-Lorentz model; negative refraction

Online: 28 March 2022 (08:56:05 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0387.v1

Mass or Energy? On Charge of Gravity

Zhong-Yue Wang

Subject: Physical Sciences, Mathematical Physics Keywords: universal gravitation; negative energy; repulsion; negative mass; MOND (Modified Newtonian Dynamics)

Online: 26 March 2020 (14:03:36 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202110.0255.v1

Exact Solutions for a Novel H₂ Optimal Design of Electromagnetic Tuned Mass Damper

Ge Li, Qibo Mao, Yifan Luo, Yong Wang, Lei Liu

Subject: Engineering, Mechanical Engineering Keywords: electromagnetic tuned mass damper; H2 optimization; structural vibration control; negative inductance; negative resistance.

Online: 18 October 2021 (15:37:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0981.v1

Sarcosine May Induce EGF Production or Inhibit the Decline in EGF Concentrations in Patients with Chronic Schizophrenia (Results of the PULSAR Study)

Agnieszka Pawlak, Bartosz Kaczmarek, Adam Wysokiński, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: EGF; sarcosine; schizophrenia; negative symptoms

Online: 14 August 2023 (04:47:40 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201811.0315.v1

Modeling Traffic Accident Occurrence at Hazardous Road Locations: A Case Study in Tunisia

Fedy Ouni, Mounir Belloumi

Subject: Business, Economics And Management, Economics Keywords: Crash counts; Hazardous Road Locations; Pearson correlation; Random effect negative binomial; Negative binomial model

Online: 13 November 2018 (13:02:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201612.0104.v1

Internalization of Negative External Cost of Logistics and Incentive Mechanism

Zhanzhong Wang, Zhouling Tsai, Jing Fu, Guangdong Tian

Subject: Engineering, Control And Systems Engineering Keywords: green logistics; negative externality of logistics; internalization of logistics negative external cost; incentive mechanism

Online: 20 December 2016 (10:37:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202204.0263.v9

Novel Recurrence Relations for Volumes and Surfaces of N-Balls, Regular N-Simplices, and N-Orthoplices in Real Dimensions

Szymon Łukaszyk

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular convex polytopes; negative dimensions; fractal dimensions

Online: 8 June 2022 (12:29:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201910.0217.v1

Aptamer Bead-Mediated Separation of Gram-Negative Bacteria Using Acoustophoresis

Sang Woo Lee, Byungw Woo Kim, Hye-Su Shin, Anna Go, Minho Lee, Dong-ki Lee, Soyoun Kim, Ok Chan Jeong

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aptamer: acoustophoresis; microfluidics; gram-negative bacteria

Online: 18 October 2019 (11:41:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202201.0230.v1

Refusal Parenting Style Is Easier for Students to Perceive Non-physical Bullying in the Upper Grades of Elementary School: Mediation Effect of Negative Affect Experience and Negative Coping Style

Houyu Zhou, Qinfei Wang, Shuxu Yu, Quangquang Zheng

Subject: Social Sciences, Psychology Keywords: perceiving campus non-physical bullying; Refusal parenting style; negative affect experiences; negative coping style; mediating effect

Online: 17 January 2022 (14:09:27 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1702.v1

BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model

Seong Min Kim, Seung Hyuck Jeon, Min Guk Han, Mi Hyun Kang, In Ah Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: BRD4; radiation therapy; triple-negative breast cancer

Online: 26 July 2023 (10:08:44 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0112.v1

Auxetic Structures from Rotating Squares

Julian Plewa, Małgorzata Płońska, Paweł Lis

Subject: Engineering, Mechanical Engineering Keywords: auxetic structures; metamaterials; negative Poisson’s ratio (NPR)

Online: 8 February 2022 (13:15:25 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201803.0174.v1

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women

Tarun Mamidi, Jiande Wu, Paul B. Tchounwou, Lucio Miele, Chindo Hicks

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: gene expression obesity triple negative breast cancer

Online: 20 March 2018 (07:56:33 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202108.0486.v1

The Modified Fundamental Equations of Quantum Mechanics in Symmetric Forms

Huai-Yu Wang

Subject: Physical Sciences, Quantum Science And Technology Keywords: Dirac equation; Klein-Gordon equation; Schrödinger equation; negative kinetic energy; Decoupled Klein-Gordon equation; negative kinetic energy Schrödinger equation

Online: 25 August 2021 (10:50:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0368.v1

The Role of Perceived Social Support in the Psychological Well-Being of Young Offenders: from Pretrial Detention to Correctional Camps

Fedor Ushkov, Roman Shilko, Ludmila Shaigerova, Alexandra Dolgikh, Olga Almazova, Olga Vakhantseva, Yuri Zinchenko

Subject: Social Sciences, Psychology Keywords: psychological well-being; young offenders; social support; pretrial detention; correctional camps; positive and negative feelings; positive and negative affects

Online: 29 November 2019 (04:16:05 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1769.v1

Neonatal Bloodstream Infection with Ceftazidime-Avibactam-Resistant KPC-2 Producing- Klebsiella pneumoniae Carrying the VEB-25 Gene

Charalampos Zarras, Elias Iosifidis, Maria Simitsopoulou, Styliani Pappa, Angeliki Kontou, Emmanuel Roilides, Anna Papa

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Multi-drug resistance; Gram-negative bacteria; Enterobacterales; carbapenemases

Online: 26 June 2023 (09:40:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.0074.v1

Triple Negative Breast Cancer Treatment Options and Limitations: Future Outlook

Onyinyechi Obidiro, Gantumur Battogtokh, Emmanuel O. Akala

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple negative breast cancer; chemotherapy; immunotherapy; limitations; nanotechnology

Online: 1 June 2023 (08:58:25 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints201912.0170.v1

Necrotic Skin Infection by Sphingomonas Paucimobilis in Amazonia Region

Talles Henrique Pichinelli Maffei, Frederico Alberto Bussolaro, Arlei Belaus, Alexandra Prevedello, Claudine Thereza-Bussolaro

Subject: Medicine And Pharmacology, Dermatology Keywords: sphingomonas; gram-negative bacterial infection; skin disease; bacterial

Online: 12 December 2019 (10:01:35 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0405.v1

Selection of A New Biasing Parameter for the Jackknife Kibria-Lukman Estimator for the Negative Binomial Regression Model

Oranye Henrietta E, Adejuwon Samuel O, Arum Kingsley C, Ugwuowo Fidelis I, Ugah Tobias E, Adegoke Taiwo M, Sule Omeiza B

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Jackknife; Kibria-Lukman; estimator; Maximum Likelihood; Negative Binomial regression

Online: 6 July 2023 (08:58:10 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.1575.v1

Application of Heisenberg’s Uncertainty Principle in the Diag-Nostic Dilemma of Children With Acute Appendicitis: Negative Appendectomy Versus Complicated Appendicitis Rates

Stylianos Roupakias, Sotirios Fouzas, Eirini Kostopoulou, Despoina Gkentzi, Theodore Dassios, Ioannis Spyridakis, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Surgery Keywords: complicated appendicitis; negative appendectomy; Heisenberg’s principle; diagnostic uncertainty; children

Online: 23 May 2023 (04:58:36 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.0146.v1

Revolutionizing Prosthetic Design with Auxetic Metamaterials: A Review of Mechanical Properties and Limitations

Muhammad Faris Fardan, Bhre Wangsa Lenggana, U Ubaidillah, Seung-Bok Choi, Didik Djoko Susilo, Sohaib Z. Khan

Subject: Engineering, Mechanical Engineering Keywords: prosthetic devices; metamaterials; auxetic structure; negative Poisson’s ratio; metastructure

Online: 3 May 2023 (12:31:06 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0026.v1

Dark Energy is Dark Matter below Absolute Zero in Black Holes

Roumen Tsekov

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Neutrino, Dark Matter, Dark Energy, Black Holes, Negative Temperature

Online: 2 February 2022 (09:35:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0195.v1

Comparative Study of Computational Models for Reducing Air Pollution Through the Generation of Negative Ions

Paola Ortiz-Grisales, Julián Patiño-Murillo, Eduardo Duque-Grisales

Subject: Engineering, Automotive Engineering Keywords: Environmental pollution; air purification; negative ion generators; particulate matter.

Online: 10 May 2021 (14:02:23 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202104.0782.v2

A Review of Electrospun Carbon Nanofiber-Based Negative Electrode Materials for Supercapacitors

Arjun Prasad Tiwari, Tanka Mukhiya, Alagan Muthurasu, Kisan Chhetri, Minju Lee, Bipeen Dahal, Prakash Chandra Lohani, Hak Yong Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: electrospinning; negative electrode materials; carbon nanofibers; free-standing; supercapacitor

Online: 10 May 2021 (09:34:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0078.v1

How Would Different Types of Negative Life Events Predict Adolescents’ Suicidal Ideation ? - an Empirical Study Based on the Western Region of China

Moye Xin, Xueyan Yang, Kun Liu

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Negative life events; Suicidal ideation; Suicidalogy; Adolescents; Gender difference

Online: 4 March 2021 (15:56:04 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202101.0517.v1

Metabolite Transporter and Its Impact on Metabolic Engineering Approaches

Mostafa Gomaa FADL

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gram-negative bacterial; Metabolite transporter; pathways; metabolic engineering approaches

Online: 25 January 2021 (15:49:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0076.v6

Unification of the Electromagnetic Force and Gravity through the Composite Photon

Ian Clague

Subject: Physical Sciences, Acoustics Keywords: Unification; Composite Photon; Negative Mass; Antimatter; Grand Unification Theory, Dark Energy, Dark Matter

Online: 28 October 2021 (10:06:39 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Inhibition of DNA Repair Pathways and Induction of ROS are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

Suzanne Bakewell, Isabel Conde, Yassi Fallah, Mathew McCoy, Lu Jin, Ayesha Shajahan-Haq

Subject: Biology And Life Sciences, Aging Keywords: breast cancer; BOLD-100; olaparib; triple negative breast cancer

Online: 22 July 2020 (10:00:52 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

On the Theory and Design of Cold Resistors

Jiaao Song, Laszlo B. Kish

Subject: Engineering, Electrical And Electronic Engineering Keywords: thermal noise; negative feedback; low-noise resistors; theory; design

Online: 31 May 2020 (19:02:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202003.0418.v1

Negative Effective Mass in Plasmonic Systems

Edward Bormashenko, Irina Legchenkova

Subject: Physical Sciences, Condensed Matter Physics Keywords: metamaterials; negative effective mass; plasma oscillations; low frequency plasmons

Online: 29 March 2020 (03:39:01 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201811.0438.v1

Adiabatic Thermodyhamics

Christian Fronsdal

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: entropy; thermodynamics; conservative hydrodynamics; rotations; meniscus; planets; negative pressure

Online: 19 November 2018 (09:42:08 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201706.0059.v1

Pathology of Adult and Paediatric Mitochondrial Myopathies

Rahul Phadke

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: mitochondrial; muscle biopsy; ragged red; COX-negative; subsarcolemmal; immunohistochemistry

Online: 13 June 2017 (06:23:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0515.v1

Shared E-scooter Practices in Birmingham, Alabama: Analyzing Usage, Patterns, and Determinants

Mithila Hasan, Virginia P. Sisiopiku

Subject: Engineering, Civil Engineering Keywords: shared micromobility; e-scooters; spatiotemporal analysis; negative binomial regression analysis

Online: 8 November 2023 (04:46:20 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1088.v1

Fetuin-A Modulates Tumor Growth and Invasion in a Basal-Like Triple Negative Breast Cancer Cell Line, MDA-MB-468

Divya Kenchappa, Olga Y Korolkova, Peace Odiase, Michael G. Izban, Amos Sakwe, Josiah Ochieng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Fetuin-A; Triple Negative; Breast Cancer; TLR4; Invasion; Basal-like

Online: 15 September 2023 (16:02:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0283.v1

The Relationship between the Family Environment and Disordered Eating Patterns: A Moderated Mediated Model of Automatic Thoughts and Gender

Badra Hamdi Alghanami, Mogeda El Sayed El Keshky

Subject: Social Sciences, Psychology Keywords: family environment; eating disorders; negative thoughts; mediation analysis; Saudi Arabia

Online: 5 July 2023 (10:40:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0268.v1

Identification of Influential Features for User Engagement with Wellness Content: Analysis of nyt_well Instagram Account

Seungjun Kim

Subject: Public Health And Healthcare, Other Keywords: wellness; health; user engagement; social media; instagram; negative binomial regression

Online: 12 April 2023 (09:46:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0133.v1

Can Radiomics Provide Additional Information in [18F]FET-Negative Glioma?

Katharina Von Rohr, Marcus Unterrainer, Adrien Holzgreve, Maximilian A. Kirchner, Zhicong Li, Lena M. Unterrainer, Bogdana Suchorska, Matthias Brendel, Jörg-Christian Tonn, Peter Bartenstein, Sibylle Ziegler, Nathalie L. Albert, Lena Kaiser

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: amino acid PET; FET PET; glioma; FET negative; photopenic; radiomics

Online: 9 September 2022 (09:31:45 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202201.0349.v1

Spatial Distribution of Cyclograpsus cinereus Dana 1851 in Rocky Shores of Antofagasta (23º27’ S, Chile)

Patricio De los Rios-Escalante, Carlos Esse, Marco Antonio Retamal, Oscar Zuñiga, Maritza Fajardo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Cyclograpsus cinereus; spatial distribution; intertidal; rocky shore; negative binomial distribution.

Online: 24 January 2022 (11:48:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0476.v1

Comparison of social inequality in HPV vaccination among teenagers with parental reports and healthcare providers’ records in the 2019 National Immunization Survey-Teen.

Sol Seo Choi, Bongkyoo Choi

Subject: Social Sciences, Sociology Keywords: Human Papillomavirus, vaccine, social inequality, NIS-Teen, false negative, SES.

Online: 30 December 2021 (00:14:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202107.0626.v1

A High Efficacy DNA Vaccine Against Tilapia Lake Virus in Nile Tilapia (Oreochromis niloticus)

Nai-tong Yu, Wei-wei Zeng, Jian-hua Wang, Yu-liang Zhang, Xiu-chun Zhang, Zhi-xin Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tilapia; negative-sense RNA virus; Tilapia lake virus; DNA vaccine

Online: 28 July 2021 (11:11:37 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202107.0614.v1

Mixed Effects and Mechanisms of Cannabinoids for Triple-Negative Breast Cancer Treatment

Khanh Tran

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Triple-negative breast cancer; cannabinoid; marijuana; cell signalling; medicinal plants

Online: 28 July 2021 (08:56:32 CEST)

Show abstract| Download PDF| Share

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the lack of estrogen receptors (ER), progesterone receptors, and HER-2 receptors. Thus, TNBC tumours do not benefit from the current therapies targeting ER or HER-2. Therefore, there is an urgent need to develop novel treatment for this subtype of breast cancer. Marijuana is a common name given to Cannabis plants, a group of plants in the Cannabis genus of the Cannabaceae family. Cannabis plants are among the oldest cultivated crops, traced back at least 12,000 years and are well known for their multi-purpose usage, including medicinal purposes. The main active compounds extracted from Cannabis plants are 21-carbon-containing terpenophenolics, which are referred to as phytocannabinoids. Of these, the tetrahydrocannabinol (THC) group contains highly potent cannabinoids, including delta-9-tetrahydrocannabinol (∆9-THC) and delta-8-tetrahydrocannabinol (∆8-THC), which are the most abundant THCs and are largely responsible for psychological and physiological effects of marijuana. The use of Cannabis plants for medicinal purposes was first recorded in 2337 BC in China, where Cannabis plants were used to treat pains, rheumatism, and gout. Recently, several cannabinoids have been approved for a number of treatments, one of which is the treatment of nausea and vomiting caused by chemotherapy in cancer patients. Furthermore, increasing evidence shows that cannabinoids not only attenuate side effects due to cancer treatment, but might also potentially possess direct antitumor effects in several cancer types, including breast cancer. However, anti-tumour activity of marijuana has been variable in different studies and even promoted tumour growth in some cases. In addition, the mechanisms of cannabinoid action in cancer remain unclear. This review summarizes evidence about the mixed actions of cannabinoids in cancer in general and triple-negative breast cancer in particular.

Preprint ARTICLE | doi:10.20944/preprints202107.0238.v1

An Idea about Negative Cosmic Time in the Big Bang-Big Rip Cosmological Model

Mohamed Abdalla Bakry, Ali Eid, A. Alkaoud

Subject: Physical Sciences, Acoustics Keywords: Negative cosmic time; cosmological solutions; variable deceleration parameter; big rip

Online: 12 July 2021 (09:46:04 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Prognostic Impact of Immunoglobulin Kappa C (IGKC) In Early Breast Cancer

Marcus Schmidt, Karolina Edlund, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, Marco J. Battista, Walburgis Brenner, Annette Hasenburg, Jörg Rahnenführer, Mathias Gehrmann, Pirkko-Liisa Kellokumpu-Lehtinen, Ralph M Wirtz, Heikki Joensuu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: triple-negative breast cancer; prognosis; immune system; immunoglobulin kappa C

Online: 31 May 2021 (12:27:49 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer

Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader El-Sayes, Karen Mossman, John Valliant

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; immunotherapy; immune checkpoint therapy; radionuclide therapy

Online: 9 April 2021 (13:26:23 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0689.v1

Alternative Invasion Mechanisms and Host Immune Response to Plasmodium vivax Malaria: Trends and Future Directions

Daniel Kepple, Kareen Pestana, Junya Tomida, Abnet Abebe, Lemu Golassa, Eugenia Lo

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Plasmodium vivax; Erythrocyte Invasion Mechanisms; Duffy Negative; Africa; Immunology; Epidemiology

Online: 27 November 2020 (13:08:59 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0178.v1

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Melissa Davis, Rachel Martini, Lisa Newman, Olivier Elemento, Jason White, Akanksha Verma, Indrani Datta, Indra Adrianto, Kevin Gardner, Hyung-Gyoon Kim, Windy Dean-Colomb, Isam Eldin Eltoum, Andra R Frost, William E. Grizzle, Andrea Sboner, Upender Manne, Clayton Yates

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; African Ancestry; RNAseq analysis; oncologic pathways

Online: 12 April 2020 (04:22:51 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201908.0064.v1

On the Trends of Registered Birth and Death Rates in Nigeria: Evidence from Generalized Linear Models

Monday Osagie Adenomon, Emmanuel Chukwuma Anikweze

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: birth; death; trends; generalized linear models (GLMs); poisson; negative binomial

Online: 5 August 2019 (14:36:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201811.0436.v1

Comparing Supervised Machine Learning Strategies and Linguistic Features to Search for Very Negative Opinions

Sattam Almatarneh, Pablo Gamallo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: sentiment analysis; opinion mining; linguistic features; classification; very negative opinions

Online: 19 November 2018 (09:35:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201609.0098.v1

Oyelola A. Adegboye, Majeed Adegboye

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: ecological niche model; environment; overdispersion; negative binomial; leishmaniasis; infectious disease

Online: 27 September 2016 (10:17:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0406.v1

A Fitted Numerical Scheme with Algorithm for Singularly Perturbed Parabolic Partial Differential Equations with Large Negative Shift

Ababi H. Ejere, Gemechis File Duressa

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Singular perturbation; Boundary layer; Interior layer; Negative shift term; Uniform convergence

Online: 7 October 2023 (09:31:16 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.1363.v1

Breast Cancer in the Arabian Gulf Countries

Humaid O. Al-Shamsi, Nadia Abdelwahed, Amin Abyad, Ibrahim Abu-Gheida, Mehdi Afrit, Tasneem Abu ElFuol, Ryad Alasas, Bilal Lababidi, Prasanta Dash, Mudhasir Ahmad, Norbert W Dreier, Urfan ul haq, Thanda Lucy Ann Joshua, Sonia Otsmane, Anwar Al-Nouri, Aydah Al-Awadhi, Syed Hammad Tirmazy, Faisal Alterkait, Shimaa Elsabae, Nyla Khan, Nehad Albastaki, Yoginee Sonawane, Mohammed Jouda, Frea Perdawood, Faryal Iqbal, Hassan Jaafar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Malignancy; Gulf Cooperation Council(GCC); Survival; HER2; Triple Negative

Online: 20 September 2023 (13:51:45 CEST)

Show abstract| Download PDF| Share

Breast cancer stands as the prevailing malignancy across all six Gulf Cooperation Council (GCC) nations. In this literature review, we highlighted the incidence and trend of BC in the GCC. Most of the studies reported a consistent increase in BC incidence over the past decades, which was particularly attributed to the adoption of a westernized lifestyle in the region and the implications of emerging risk factors and other environmental and societal factors, the increase in screening uptake, as well as the improvement in data collection and reporting in the GCC. The data about BC risk factors in GCC was limited. In this geographic region, breast cancer frequently manifests with distinctive characteristics, including an early onset, typically occurring before the age of 50, an advanced stage at presentation, and a higher pathological grade. Additionally, it often exhibits more aggressive features such as human epidermal growth factor receptor 2 (HER2) positivity or the presence of triple-negative (TN) attributes, particularly among younger patients. Despite the growing body of literature on breast cancer in the GCC, data pertaining to survival rates are, regrettably, meager. Reports on breast cancer survival rates emanating from the GCC region are largely confined to Saudi Arabia and the United Arab Emirates (UAE). In the UAE, predictive modeling reveals 2-year and 5-year survival rates of 97% and 89%, respectively, for the same period under scrutiny. These rates, when compared to Western counterparts such as Australia (89.5%) and Canada (88.2%), fall within the expected range. Conversely, Saudi Arabia reports a notably lower 5-year survival rate, standing at 72%. This disparity in survival rates underscores the need for further research directed towards elucidating risk factors and barriers that hinder early detection and screening. Additionally, there is a pressing need for expanded data reporting on survival outcomes within the GCC. In sum, a more comprehensive and nuanced understanding of breast cancer dynamics in this region is imperative to inform effective strategies for prevention, early detection, and improved patient outcomes.

Preprint ARTICLE | doi:10.20944/preprints202306.0109.v1

MCAK Inhibitors Induce Aneuploidy in Triple Negative Breast Cancer Models

John C Smith, Stefan Husted, Jay Pilrose, Stephanie C Ems-McClung, Jane R Stout, Richard L Carpenter, Claire E Walczak

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: triple negative breast cancer; MCAK/KIF2C; aneuploidy; chromosomal instability; drug discovery

Online: 1 June 2023 (15:47:29 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1852.v1

Beyond Bullying, Aggression, Discrimination, Social Safety: Development of an Integrated Negative Work Behavior Questionnaire (INWBQ)

Cokkie Verschuren, Maria Tims, Annet H. De Lange

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: diagnostic instrument; employee wellbeing; harm; Negative Work Behavior (NWB); bystander roles

Online: 26 May 2023 (04:41:39 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0028.v1

Depolarizing Effects in Hydrogen Bond Energy in 3₁₀-Helices Revealed by Quantum Chemical Analysis

Hiroko X. Kondo, Haruki Nakamura, Yu Takano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: 310-helix; hydrogen bond energy; density functional theory; negative fragmentation analysis

Online: 2 August 2022 (03:15:55 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202204.0080.v1

The Effect of Negative Mass in Gravitating System

Edward Bormashenko

Subject: Physical Sciences, Applied Physics Keywords: core-spring-shell system; gravitating system; negative mass; Coulomb-like forces

Online: 8 April 2022 (11:12:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0133.v1

Phenotypic Heterogeneity Drives Differential Disease Outcome in Triple Negative Breast Cancer

Archana P. Thankamony, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Radhika Nair

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Intratumoral heterogeneity; Triple negative breast cancer (TNBC); Macc1; Phenotypic heteroge-neity

Online: 9 February 2022 (10:40:54 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0042.v1

Modulation Instability of Hydro-Elastic Waves Blown by a Wind with a Uniform Vertical Profile

S. Boral, T. Sahoo, Y. Stepanyants

Subject: Physical Sciences, Mathematical Physics Keywords: Wind wave; Ice cover; Vortex sheet; Negative energy wave; Modulation instability

Online: 2 November 2021 (10:53:15 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0041.v1

Negative-Curvature Spacetime Solutions for Graphene

Antonio Gallerati

Subject: Physical Sciences, Acoustics Keywords: negative-curvature spacetime; field theories in lower dimensions; graphene theoretical physics

Online: 2 November 2020 (13:24:36 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0527.v1

Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells

Andrew Sulaiman, Sarah McGarry, Jason Chambers, Emil Al-Kadi, Alexandra Phan, Li Li, Karan Mediratta, Jim Dimitroulakos, Christina Addison, Xuguang Li, Lisheng Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; Hypoxia; EGFR; Cisplatin; PDX

Online: 22 July 2020 (11:32:30 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

Turkish Adaptation of the Positive-Negative Relationship Quality (PN-RQ) Scale: A Reliability and Validity Study

Arzu Araz, Duygu Güngör, Eda Aşçı

Subject: Social Sciences, Psychology Keywords: positive-negative relationship quality; reliability; validity; confirmatory factor analysis (CFA); bifactor

Online: 16 September 2019 (16:33:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201812.0314.v1

From Individual Resource to Social Capital: The Mechanism of How Political Skill Affect Job Satisfaction and Turnover Intention

Yi Li, Mengqiu Ma

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: political skill; job satisfaction; turnover intention; popularity; positive affect; negative affect

Online: 26 December 2018 (12:16:31 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201807.0263.v1

Geometry of Chalcogenide Negative Curvature Fibers for CO₂ Laser Transmission

Chengli Wei, Curtis R. Menyuk, Jonathan Hu

Subject: Physical Sciences, Optics And Photonics Keywords: CO2 lasers; negative curvature fibers; chalcogenide glass; fiber loss; mid-IR

Online: 16 July 2018 (08:40:16 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1720.v1

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

Samantha Greaves, Caroline Harvey, Yashuhiro Kotera

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate change; positive and negative affect; pro-environmental behavioural intentions; climate anxiety

Online: 28 November 2023 (08:15:55 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0110.v1

Plasmid-Mediated Genes Were Responsible for the Resistance and Spread of Metallo Beta-Lactamase (MBL)-Producing Pseudomonas Aeruginosa Isolates in Poultry Milieus

Chika Ejikeugwu, Carissa Duru, Euslar Onu, Emmanuel Nwakaeze, Cyril Adonu, Ndidiamaka Okorie, Nonye Ujam, Ijeoma Ebenebe, Theodora Mba, Anthonia Mba, Chika Ezeador, Chijioke Edeh, Malachy Ugwu, Michael Adikwu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Gram negative bacteria; multidrug resistance; plasmids; carbapenemase; carbapenems; mobile genetic elements (MGEs)

Online: 4 September 2023 (07:17:41 CEST)

Show abstract| Download PDF| Share

Bacterial resistance to antibiotics is a public health menace that needs urgent efforts to mitigate and forestall their transmission in the general environment. Plasmid-mediated metallo beta-lactamase (MBL) gives bacteria an exceptional ability to transmit resistance genes. This study investigated plasmid-mediated resistance in MBL P. aeruginosa isolates from poultry food chain settings. Cloacal swab samples (n=120) were bacteriologically analyzed for the isolation of P. aeruginosa isolates. Susceptibility studies were performed by the CLSI guideline using selected antibiotics. MBL was phenotypically detected using modified Hodges test, and confirmed using PCR technique. Plasmid curing studies detected the presence of plasmids in the isolates. P. aeruginosa isolates (n=48) showed high levels of reduced susceptibility to cefoxitin (93.8%), imipenem (81.3%), gentamicin (85.4%), amikacin (85.4%), nitrofurantoin (83.3%), ofloxacin (72.9%) and cefotaxime (77.1%). MBL was phenotypically detected in 7 (14%) isolates of P. aeruginosa. The presence of blaIMP-1 and blaIMP-2 MBL genes in P. aeruginosa (n=5) isolates was confirmed by PCR. The PCR did not detect blaVIM-1 and blaVIM-2 MBL genes. The P. aeruginosa isolates were multidrug resistant, with about 50% of the isolates showing multidrug resistance (MDR) to the antibiotics. The genes for MDR in the P. aeruginosa isolates were borne on plasmids, indicating a high possibility of community transmission of MBL resistance genes. Finally, the P. aeruginosa isolates from poultry food chain milieus are multidrug resistant, produce MBL, and harbour their resistance genes on plasmids. Since many antibiotic resistance genes in bacteria are associated with mobile genetic elements (MGEs) like plasmids, it is important to step up actions to mitigate incessant use of antibiotics in poultry and other agricultural practices in Nigeria in order to diminish the evolution and spread of plasmid-mediated resistance which is capable of initiating community acquired infections that may prove difficult to treat in our hospitals with the available antibiotics.

Preprint REVIEW | doi:10.20944/preprints202308.2077.v1

A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis

Klaus Brandenburg, Raquel Ferrer-Espada, Guillermo Martinez De Tejada, Christian Nehls, Satoshi Fukuoka, Karl Mauss, Günther Weindl, Patrick Garidel

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: sepsis; lipopolysaccharide; gram-negative bacteria; covid pandemic; hyperinflammation; TLR4; cytokines; ARDS; Aspidasept

Online: 31 August 2023 (03:41:27 CEST)

Show abstract| Download PDF| Share

Sepsis is a life-threatening condition caused by the body's overwhelming response to an infection, such as pneumonia or urinary tract infection. It occurs when the immune system releases cytokines into the bloodstream, triggering widespread inflammation. If not treated, it can lead to organ failure and death. Unfortunately, sepsis has a high mortality rate, with studies reporting rates ranging from 20% to over 50%, depending on the severity and promptness of treatment. According to the World Health Organization (WHO), the annual death toll in the world is about 11 million. One of the main toxins responsible for inflammation induction are lipopolysaccharides (LPS, endotoxin) from Gram-negative bacteria, which ranks among the most potent immunostimulants found in nature. Antibiotics are consistently prescribed as a part of anti-sepsis-therapy. However, antibiotic therapy (i) is increasingly ineffective due to resistance development and (ii) most antibiotics are unable to bind and neutralize LPS, a prerequisite to inhibit the interaction of endotoxin with its cellular receptor complex, namely Toll-like receptor 4 (TLR4)/MD-2, responsible for the intracellular cascade leading to pro-inflammatory cytokine secretion. The pandemic virus SARS-CoV-2 has infected hundreds of millions of humans worldwide since its emergence in 2019. The COVID-19 (Coronavirus disease-19) caused by this virus is associated with high lethality, particularly for elderly and immunocompromised people. As of August 2023, nearly 7 million deaths were reported worldwide due to this disease. According to some reported studies, upregulation of TLR4 and the subsequent inflammatory signaling detected in COVID-19 patients “mimics bacterial sepsis”. Furthermore, the immune response to SARS-CoV-2 was described by others as “mirror image of sepsis”. Similarly, the cytokine profile in sera from severe COVID-19 patients was very similar to those suffering from the acute respiratory distress syndrome (ARDS) and sepsis. Finally, the severe COVID-19 infection was frequently accompanied by bacterial co-infections, as well as by the presence of significant LPS concentrations. These data indicate similarity and interdependences of both syndromes, but also significant differences which will be discussed in the present review.

Preprint ARTICLE | doi:10.20944/preprints202306.1836.v1

Conversion of Polypropylene (PP) foams into Auxetic Metamaterials

Xiao Yuan Chen, Denis Rodrigue

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Polypropylene; foam; upcycling; negative Poisson's ratio; auxetic materials; cellular structure; mechanical properties.

Online: 26 June 2023 (21:55:19 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0434.v1

Identification of a NACC1-Regulated Gene Signature Impli-Cated in the Features of Triple-Negative Breast Cancer

Xia Liu, Chrispus Ngule, Hami Hemati, Oluwafunminiyi Obaleye, Amos Oyelami, Felix Oyelami, Xingcong Ren, Jianxun Song, Xiaofang Xiong, Jin-ming Yang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Tumor progression; cancer stem cells; gene signature; NACC1; triple negative breast cancer

Online: 27 February 2023 (03:10:34 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202211.0296.v1

N10-C11 Imine is Essential for Gram-negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines

Pietro Picconi, Charlotte K. Hind, J. Mark Sutton, Khondaker Miraz Rahman

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: antimicrobial resistance; broad-spectrum antibiotics; antibacterial drug discovery; gram-negative bacteria; pyrrolobenzodiazepines

Online: 16 November 2022 (04:20:55 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0433.v1

Spiropyran/Merocyanine Amphiphile in Various Solvents: A Joint Experimental–Theoretical Approach to Photophysical Properties and Self-Assembly

Vladyslav Savchenko, Nino Lomadze, Svetlana Santer, Olga Guskova

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: spiropyran/merocyanine isomerization; negative photochromism; time-resolved UV-vis measurements; molecular modeling

Online: 25 August 2022 (10:22:35 CEST)

Show abstract| Download PDF| Share

This joint experimental-theoretical work focuses on molecular and photophysical properties of the spiropyran-containing amphiphilic molecule in organic and aqueous solutions. Being dissolved in tested organic solvents, the system demonstrates positive photochromism, i.e. upon UV stimulus the colorless spiropyran form is transformed into colorful merocyanine isomer. However, aqueous solution of the amphiphile possesses a negative photochromism: the orange-red merocyanine form turns to be thermodynamically more stable in water, and both UV and vis stimuli lead to the partial or complete photobleaching of the solution. The explanation of this phenomenon is given on the basis of density functional theory calculations and classical modeling including thermodynamic integration. The simulations reveal that stabilization of merocyanine in water proceeds with the energy of ca. 70 kJ mol−1, and that the Helmholtz free energy of hydration of merocyanine form is 100 kJ mol−1 lower as compared to the behavior of SP isomer in water. The explanation of such a difference lies in the molecular properties of the merocyanine: after ring-opening reaction this molecule transforms into a zwitterionic form, as evidenced by the electrostatic potential plotted around the opened form. The presence of three charged groups on the periphery of a flat conjugated backbone stimulates the self-assembly of merocyanine molecules in water, ending up with the formation of elongated associates with stack-like building blocks, as shown in molecular dynamics simulations of the aqueous solution with the concentration above critical micelle concentration. Our quantitative evaluation of the hydrophilicity switching in spiropyran/merocyanine containing surfactants may prompt the search for new systems, including colloidal and polymeric ones, aiming at remote tuning of their morphology, which could give new promising shapes and patterns for the needs of modern nanotechnology.

Preprint ARTICLE | doi:10.20944/preprints202206.0233.v1

Social Robots Outdo the Not-so-Social Media for Self-disclosure: Safe Machines Preferred to Unsafe Humans?

Rowling Luo, Thea Zhang, Derrick Chen, Johan F. Hoorn, Ivy Huang

Subject: Business, Economics And Management, Accounting And Taxation Keywords: social media; social robots; negative mood; self-disclosure; intervention design; anthropomorphic design

Online: 16 June 2022 (06:11:48 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202203.0297.v1

The Effect of Intratumoral Interrelation among FOXP3+ Regulatory T cells on Treatment Response and Survival in Triple-Negative Breast Cancer

Noriko Goda, Chika Nakashima, Ichiro Nagamine, Sunao Otagaki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: regulatory T cell; tumor-infiltrating lymphocyte; neoadjuvant chemotherapy; triple-negative breast cancer

Online: 22 March 2022 (07:50:45 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202102.0130.v1

A Novel Treatment of the Josephson Effect

Jacob Szeftel, Nicolas Sandeau, Michel Abou Ganthous

Subject: Physical Sciences, Acoustics Keywords: Josephson effect; transport properties; critical current; tunnelling; superconducting-normal transition; negative resistance

Online: 4 February 2021 (10:01:16 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0568.v1

Perceived Help-Seeking Difficulty, Barriers, Delay, and Burden in Carers of People with Suspected Dementia

Carmen KM Ng, Dara KY Leung, Xinxin Cai, Gloria HY Wong

Subject: Business, Economics And Management, Accounting And Taxation Keywords: service accessibility; dementia knowledge; affordability; carer role strain; self-criticism; negative emotions

Online: 27 January 2021 (16:15:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0279.v2

COVID-19 Testing – Impact of Prevalence, Sensitivity, and Specificity on Patient Risk and Cost

Zoe C. Brooks, Saswati Das

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID19; risk; clinical; metrics; cost; false-positive; false-negative; prevalence; sensitivity; specificity

Online: 9 July 2020 (15:57:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0117.v1

Using Negative Pressure Wound Therapy in the Treatment of Wounds After Fasciotomy in Acute Compartment Syndrome - Retrospective Case Series Study

Jaroslaw P. Miszczuk, Maria Błońska-Staniec, Anna Michalska, Bartosz Stemplewski

Subject: Medicine And Pharmacology, Surgery Keywords: acute compartment syndrome; negative pressure wound therapy; vacuum assisted wound closure; fasciotomy

Online: 8 April 2020 (04:50:32 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201908.0225.v1

Analysis of Water Bodies under Partial Cloud Conditions Using Satellite Images

Rahul Neware, Mansi Thakare

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: water bodies; satellite images; vector data; SVM; positive and negative buffering; polygons

Online: 21 August 2019 (10:30:16 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1186.v1

Distinction between Effects of IR-Drop and Negative Capacitance of Fast Cyclic Voltammograms

Yuanyuan Liu, Koichi Jeremiah Aoki, Jingyuan Chen

Subject: Chemistry And Materials Science, Electrochemistry Keywords: IR-drop; negative capacitance; double layer capacitance; fast scan cyclic voltammograms; microelectrode reactions

Online: 16 August 2023 (10:44:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1601.v1

Antimicrobial Potential of the Microalgae Extracts

Alexander Lykov, Alexei Salmin, Ruslan Gevorgiz, Svetlana Zheleznova, Lyubov Rachkovskaya, Maria Surovtseva, Olga Poveshchenko

Subject: Biology And Life Sciences, Life Sciences Keywords: diatoms; cyanobacter; green microalgae; Gram-positive and Gram-negative bacteria; Mycobacteria; antimicrobial potential

Online: 24 July 2023 (10:46:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0858.v1

Mortality Due to Multi-Drug Resistant Gram Negative Bacteremia in an Endemic Region: No Better than Toss a Coin

Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Gram-negative bacilli bacteremia; multidrug resistance; 28-day mortality; procalcitonin; rapid molecular diagnostics

Online: 11 May 2023 (13:34:03 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Negative Effective Mass in Plasmonic Systems, II: Elucidating of Optical and Acoustical Branches of Vibrations and the Possibility of Anti-Resonance Propagation

Edward Bormashenko, Irina Legchenkova, Mark Frenkel

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: metamaterials; negative effective mass; plasma oscillations; low frequency plasmons; optical and acoustical branches.

Online: 21 July 2020 (13:38:18 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201910.0255.v1

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-negative (ESKAPEE) Bacteria

Akif Reza, J. Mark Sutton, Khondaker Miraz Rahman

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: antimicrobial resistance; biofilm; efflux pump inhibitors; antibiotic potentiation; eskapee pathogens; gram-negative bacteria

Online: 22 October 2019 (10:22:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201805.0026.v1

Weighted Negative Binomial Poisson-Lindley Distribution with Actuarial Applications

Hossein Zamani, Noriszura Ismail, Marzieh Shekari

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: weighted distribution; Poisson-Lindley distribution; discrete distribution; weighted negative binomial Poisson-Lindley distribution

Online: 2 May 2018 (11:47:51 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0674.v1

Breast Cancer Bone Metastasis Lesion Segmentation on Bone Scintigraphy

Yi-You Chen, Po-Nien Yu, Yung-Chi Lai, Te-Chun Hsieh, Da-Chuan Cheng

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: bone metastasis segmentation; Double U-Net; pre-train; negative mining; transfer learning; deep learning

Online: 11 July 2023 (10:18:40 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1209.v1

Medication Review With Follow-up for End-stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated With Medication. A Systematic Review

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: End-stage renal disease; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 June 2023 (10:13:13 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.1664.v1

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Shanisa Naidoo, Arnold M Zwane, Ahmed Paruk, Timothy Craig Hardcastle

Subject: Medicine And Pharmacology, Surgery Keywords: Soft tissue; necrotizing infection; water borne; vibrio; fungal; aeromonas; debridement; negative pressure wound care

Online: 23 May 2023 (14:43:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0089.v6

Omnidimensional Convex Polytopes

Szymon Łukaszyk, Andrzej Tomski

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular basic convex polytopes; circumscribed and inscribed polytopes; negative dimensions; fractal dimensions; complex dimensions; emergent dimensionality; mathematical physics

Online: 24 February 2023 (15:41:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0094.v3

“Clinician’s Probability Calculator” to Convert Pre-Test to Post-Test Probability of COVID-19, Based on Method Validation from Each Laboratory

Zoe Brooks, Saswati Das, Tom Pliura

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-COV-2; False-Positive; False-Negative; Likelihood Ratio; Probability; Calculator; Interpretation

Online: 3 March 2021 (10:08:27 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201801.0100.v1

Pressure Distribution during Negative Pressure Wound Therapy of Experimental Abdominal Compartment Syndrome in a Porcine Model

Adrienn Csiszkó, Klaudia Balog, Zoltán Attila Godó, Gyula Juhász, Katalin Pető, Ádám Deák, Mariann Berhés, Norbert Németh, Zsolt Bodnár, Zsolt Szentkereszty

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: intra-abdominal pressure; abdominal compartment syndrome; pressure sensor; negative pressure wound therapy; open abdomen;

Online: 11 January 2018 (09:17:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201706.0077.v1

Are Mobile Live Animal Programs Educationally Beneficial? A Critical Assessment of the Human Learning Component Underlying Traveling Animal Exhibits

Kathryn Sussman

Subject: Social Sciences, Education Keywords: zoo; mobile zoo; mobile animal exhibits; animal display; mobile live animal programs; negative education

Online: 16 June 2017 (05:32:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0688.v1

Direct Quantitation of SARS-CoV-2 Using Droplet Digital PCR in Suspected Samples With Very Low Viral Load

Michela Deiana, Chiara Piubelli, Antonio Mori, Gian Paolo Chiecchi, Giulia La Marca, Martina Leonardi, Davide Treggiari, Anna Beltrame, Lucia Moro, Zeno Bisoffi, Elena Pomari

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: droplet digital PCR; real time RT-PCR; SARS-CoV-2; false negative; viral load; diagnosis

Online: 26 April 2021 (20:09:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202004.0201.v2

Detecting the Coronavirus (COVID-19)

Pravin Pokhrel, Changpeng Hu, Hanbin Mao

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2 Detection, SARS-CoV-2 Antibody Test, SARS-CoV-2 Antigen Test, False Negative, False Positive, Sensitivity, Specificity, Point-of-care testing (POCT), SARS-CoV-2 Mutants

Online: 25 March 2021 (15:33:14 CET)

Show abstract| Download PDF| Share

The COVID-19 pandemic has created huge damage to society and brought panics around the world. Such panics can be ascribed to the seemingly deceptive features of the COVID-19: compared to other deadly viral outspreads, it has medium transmission and mortality rates. As a result, the severity of the causative coronavirus, SARS-CoV-2, was deeply underestimated by the society at the beginning of the COVID-19 outbreak. Based on this, in this review, we define the viruses with features similar to those of SARS-CoV-2 as the Panic Zone viruses. To contain those viruses, accurate and fast diagnosis followed by effective isolation and treatment of patients are pivotal at the early stage of virus breakouts. This is especially true when there is no cure or vaccine available for a transmissible disease, which is the case for current COVID-19 pandemic. As of January 2021, more than two hundred kits for the COVID-19 diagnosis on the market are surveyed in this review, while emerging sensing techniques for SARS-CoV-2 are also discussed. It is of critical importance to rationally use these kits for the efficient management and control of the Panic Zone viruses. Therefore, we discuss guidelines to select diagnostic kits at different outbreak stages of the Panic Zone viruses, SARS-CoV-2 in particular. While it is of utmost importance to use nucleic acid-based detection kits with low false negativity (high sensitivity) at the early stage of an outbreak, the low false positivity (high specificity) gains its importance at later stages of the outbreak. When a society is set to reopen from the lock-down stage of the COVID-19 pandemic, it becomes critical to have antibody based immunoassay kits with high specificity to identify people who can safely return to the society after their recovery of SARS-CoV-2 infections. Given that the emergence of mutant viruses at the beginning of 2021 has complicated current battle against the COVID-19, we also discussed approaches and guidelines to detect viral mutants in the middle of the second wave of the pandemic that started at the end of 2020. Finally, since a massive attack from a viral pandemic requires a massive defense from the whole society, we urge both government and private sectors to research and develop more affordable and reliable point-of-care testing (POCT) kits, which can be used massively by the general public (and therefore called as massive POCT) to contain Panic Zone viruses in future.

Preprint ARTICLE | doi:10.20944/preprints201608.0049.v2

Understanding Farmers’ Decision Making in Agricultural Water Fee Payment in China: The Role of Mental Accounting

Weikang Zhang, Xinhong Fu, Jing Lu, Lin Zhang, Kwamega Michael, Guoqiang Liu, Yuying Liu, Fan Yang

Subject: Business, Economics And Management, Economics Keywords: mental accounting; agricultural water fee; behavioral economics; decision making; information processing; representativeness; negative psychological externalities

Online: 25 August 2016 (10:12:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0589.v1

Double Negative B lymphocytes are increased in patients with Systemic Lupus Erythematosus and they are correlated with early differentiated T lymphocyte subpopulations

Eleni Moysidou, Georgios Lioulios, Michalis Christodoulou, Aliki Xochelli, Stamatia Stai, Myrto Iosifidou, Artemis Iosifidou, Sophia Briza, Dimitria Ioanna Briza, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Systemic Lupus Erythematosus; Lupus nephritis; Double negative B lymphocytes; T lymphocytes; early differentiated cells; senescent lymphocytes

Online: 10 July 2023 (10:33:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202306.0507.v1

Immune Microenvironment and PD-L1 Expression in Breast Cancer: A Review of Current Evidence and Prognostic Implications from Pathologist’s Perspective

Giuseppe Angelico, Giuseppe Broggi, Giordana Tinnirello, Lidia Puzzo, Giada Maria Vecchio, Lucia Salvatorelli, Lorenzo Memeo, Angela Santoro, Gaetano Magro, Rosario Caltabiano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; TILs; PD-L1; immunotherapy; chemotherapy, triple negative breast cancer; HER2; luminal breast cancer; CPS

Online: 7 June 2023 (08:04:20 CEST)

Show abstract| Download PDF| Share

Search Results

161 articles found