Search | Preprints.org

Preprint REVIEW | doi:10.20944/preprints202004.0201.v2

Pravin Pokhrel, Changpeng Hu, Hanbin Mao

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2 Detection, SARS-CoV-2 Antibody Test, SARS-CoV-2 Antigen Test, False Negative, False Positive, Sensitivity, Specificity, Point-of-care testing (POCT), SARS-CoV-2 Mutants

Online: 25 March 2021 (15:33:14 CET)

Show abstract| Download PDF| Share

The COVID-19 pandemic has created huge damage to society and brought panics around the world. Such panics can be ascribed to the seemingly deceptive features of the COVID-19: compared to other deadly viral outspreads, it has medium transmission and mortality rates. As a result, the severity of the causative coronavirus, SARS-CoV-2, was deeply underestimated by the society at the beginning of the COVID-19 outbreak. Based on this, in this review, we define the viruses with features similar to those of SARS-CoV-2 as the Panic Zone viruses. To contain those viruses, accurate and fast diagnosis followed by effective isolation and treatment of patients are pivotal at the early stage of virus breakouts. This is especially true when there is no cure or vaccine available for a transmissible disease, which is the case for current COVID-19 pandemic. As of January 2021, more than two hundred kits for the COVID-19 diagnosis on the market are surveyed in this review, while emerging sensing techniques for SARS-CoV-2 are also discussed. It is of critical importance to rationally use these kits for the efficient management and control of the Panic Zone viruses. Therefore, we discuss guidelines to select diagnostic kits at different outbreak stages of the Panic Zone viruses, SARS-CoV-2 in particular. While it is of utmost importance to use nucleic acid-based detection kits with low false negativity (high sensitivity) at the early stage of an outbreak, the low false positivity (high specificity) gains its importance at later stages of the outbreak. When a society is set to reopen from the lock-down stage of the COVID-19 pandemic, it becomes critical to have antibody based immunoassay kits with high specificity to identify people who can safely return to the society after their recovery of SARS-CoV-2 infections. Given that the emergence of mutant viruses at the beginning of 2021 has complicated current battle against the COVID-19, we also discussed approaches and guidelines to detect viral mutants in the middle of the second wave of the pandemic that started at the end of 2020. Finally, since a massive attack from a viral pandemic requires a massive defense from the whole society, we urge both government and private sectors to research and develop more affordable and reliable point-of-care testing (POCT) kits, which can be used massively by the general public (and therefore called as massive POCT) to contain Panic Zone viruses in future.

Preprint ARTICLE | doi:10.20944/preprints201704.0102.v1

Age-Related Diseases as Vicious Cycles

Aleksey V. Belikov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; age-related disease; mortality rate; positive feedback loop; vicious cycle

Online: 18 April 2017 (02:45:04 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201802.0095.v1

EP4 as a Therapeutic Target for Aggressive Human Breast Cancer

Mousumi Majumder, Pinki Nandi, Ahmed Omar, Kingsley Chukwunonso Ugwuagbo, Peeyush K. Lala

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: COX-2; breast cancer; PGE2; EP receptors; stem-like cells; metastasis; angiogenesis; lymphangiogenesis; MicroRNAs; triple negative breast cancer

Online: 13 February 2018 (09:16:54 CET)

Show abstract| Download PDF| Share

G protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular ligands and transmit signals to an intracellular guanine nucleotide-binding protein (G protein). When a ligand binds, the receptor activates the attached G-protein by causing the exchange of Guanosine-5'-triphosphate (GTP) for guanosine diphosphate (GDP). They play a major role in many physiological functions as well as in the pathology of many diseases including cancer progression and metastasis. Only a few GPCR members have been exploited as targets for developing drugs with therapeutic benefit in cancer. Present review deals with the Prostaglandin E receptor EP4, a member of the EP family of GPCR, as a promising newer therapeutic target for treating breast cancer. We show that aberrant over-expression of cyclooxygenase (COX)-2, an inflammation-associated enzyme, occurring in 40-50% of breast cancer patients leads to tumor progression and metastasis due to multiple cellular events resulting from an increased prostaglandin (PG) E2 production in the tumor milieu. They include inactivation of host anti-tumor immune (NK and T) cells, increased immuno-suppressor function of tumor-associated macrophages, promotion of tumor cell migration, invasiveness and tumor-associated angiogenesis (due to upregulation of VEGF-A), lymphangiogenesis (due to upregulation of VEGF-C/D) and a stimulation of stem-like cell (SLC) phenotype in cancer cells. All these events were primarily mediated by activation of the PGE receptor EP4 on tumor or host cells. We show that selective EP4 antagonists (EP4A) could mitigate all these events tested with cells in vitro as well as in vivo in syngeneic COX-2 expressing mammary cancer bearing mice or immune-deficient mice bearing COX-2 over-expressing human breast cancer xenografts. We suggest that EP4A can avoid thrombo-embolic side effects of long term use of COX-2 inhibitors by sparing cardio-protective roles of PGI2 via IP receptor activation or PGE2 via EP3 receptor activation. Furthermore, we identified two COX-2/EP4 induced oncogenic and SLC-stimulating microRNAs - miR526b and miR655, one of which (miR655) appears to be a potential blood biomarker in breast cancer patients, for monitoring SLC-ablative therapies such as with EP4A. We suggest that EP4A will likely produce the highest benefit in aggressive breast cancers such as COX-2 expressing triple-negative breast cancers, when combined with other newer agents such as PD-1 or PD-L1 inhibitors.

Working Paper ARTICLE

Interrogating Hope Theory

Jacob Shivley

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: interrogating hope theory, hope theory, hope, the hope scale, positive psychology

Online: 25 March 2019 (09:53:58 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints201807.0482.v1

Quantum Correlations and Permutation Symmetries

Mrittunjoy Guha Majumdar

Subject: Physical Sciences, Quantum Science And Technology Keywords: Quantum Entanglement, Separability, Positive Partial Transpose Criterion, Permutation, Quantum Information, Quantum Computing, Quantum Communication, Quantum Non-locality, Quantum Correlations, SWAP Operator

Online: 25 July 2018 (12:20:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201805.0344.v1

Vitamin D Content of Australian Native Food Plants and Australian-Grown Edible Seaweed

Laura J. Hughes, Lucinda J. Black, Jill L. Sherriff, Eleanor Dunlop, Norbert Strobel, Robyn M. Lucas, Janet F. Bornman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: LC-QQQ; liquid chromatography; triple quadrupole; vitamin D; 25(OH)D; plants; algae

Online: 24 May 2018 (09:27:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201712.0009.v1

Grain Refinement Kinetics in a Low Alloyed Cu-Cr-Zr Alloy Subjected to Large Strain Deformation

Anna Morozova, Elijah Borodin, Vladimir Bratov, Sergey Zherebtsov, Andrey Belyakov, Rustam Kaibyshev

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Cu-Cr-Zr alloy; grain refinement; severe plastic deformation; triple junctions; grain refinement kinetics

Online: 1 December 2017 (16:05:29 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201705.0206.v1

Genome Characterization of a Novel Binary Toxin-Positive Strain of Clostridium difficile and Comparison with the Epidemic 027 and 078 Strains

Zhong Peng, Sidi Liu, Xiujuan Meng, Wan Liang, Biao Tang, Yuanguo Wang, Juping Duan, Chenchao Fu, Bin Wu, Anhua Wu, Chunhui Li

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Clostridium difficile; ST201; binary toxin-positive; whole genome sequencing; comparative genomic analysis

Online: 30 May 2017 (06:15:11 CEST)

Show abstract| Download PDF| Share

A novel binary toxin-positive non-027, non-078 Clostridium difficile strain designated LC693 whose sequence type was ST201 was isolated from the fecal sample of a patient with severe diarrhea in China. To understand the pathogenesis basis of C. difficile ST201, this recently recovered isolate LC693 was then chosen for whole genome sequencing. The project finally generated an estimated genome size of approximately 4.07 Mbp. The genome sequence was then analyzed together with the other two ST201 strains VL-0104 and VL-0391 and compared to the epidemic 027/ST1 and 078/ST11 strains. Phylogenetic analysis demonstrated that the ST201 strains belonged to clade 3. Genome size of the three ST201 strains ranged from 4.07 Mb~4.16 Mb, with an average GC content between 28.5%~28.9%. The ST201 genomes contained more than 40 antibiotic resistance genes and 15 of them were predicted to be associated with vancomycin-resistance, suggesting that they may have a strong antibiotic resistance. The ST201 strains contained a typical clade 3 specific PaLoc with a Tn6218 element inserted, and those genes harbored on their PaLoc that participated in the toxin expression and regulation were highly homologues to the epidemic 027 and 078 strains, with the exception of tcdC. A truncated TcdC was found in the ST201 strains, which is suggestive to have a contribution to the toxin production of the ST201 strains. In addition, the ST201 strains contained intact binary toxin coding and regulation genes, which is also proposed to contribute to the virulence. Genome comparison of the ST201 strains with the epidemic 027 and 078 strain identified 641 genes specific for the C. difficile ST201, and a number of them were predicted as fitness and virulence associated genes. The identification of those genes also contributes to the pathogenesis of the ST201 strain. To our knowledge, this is the first study that the genome sequence of C. difficile ST201 was discussed in detail, and the present study would have a contribution to understanding the pathogenesis basis of C. difficile ST201.

Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201808.0138.v1

Who is the Muslim? Discursive Representations of the Muslims and Islam in Indian Prime Time News

Onaiza Drabu

Subject: Social Sciences, Political Science Keywords: politics of representation; media; Islam; media representation; Muslims; Islamophobia.; racism; anti-Muslim racism; love jihad; triple talaq; Muslims in India

Online: 7 August 2018 (08:27:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0279.v2

COVID-19 Testing – Impact of Prevalence, Sensitivity, and Specificity on Patient Risk and Cost

Zoe C. Brooks, Saswati Das

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID19; risk; clinical; metrics; cost; false-positive; false-negative; prevalence; sensitivity; specificity

Online: 9 July 2020 (15:57:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0332.v2

Witnessing Evolution of SARS-CoV-2 through Comparative Phylogenomics: The Proximate Origin is Guangdong, not Wuhan

Özgül Doğan, Ertan Mahir Korkmaz, Mahir Budak, Battal Çıplak, Hasan Hüseyin Başıbüyük

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: coronavirus; substitution rate; positive selection; demographic dynamics

Online: 21 June 2020 (16:10:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

A new form of coronavirus called severe acute respiratory disease coronavirus type 2 (SARS-CoV-2) is currently causing a pandemic. A six-month evolutionary history of SARS-CoV-2 is witnessed by characterising the total genome of 821 samples using comparative phylogenomic approaches. Our analyses produced striking inclusive results that may guide scientists/professionals for the past/future of pandemic. Phylogenetic and time estimation analyses suggest the proximate origin of pandemic strain as Guangdong and the origin time as first half of September 2019, not Wuhan and December 2019, respectively. The viral genome experienced a substitution rate similar to other RNA viruses, but it is particularly high in some of the peptides encoding sequences such as leader protein, E gene, orf8, orf10, nsp10, N gene, S gene and M gene and nsp4, while low in nsp11, orf7a, 3C-like proteinase, nsp9, nsp8 and endoRNase. Most strikingly, the divergence rate of amino acid sequences is high proportional to nucleotide divergence. Additionally, specific non-synonymous mutations in nsp3 and nsp6 evolved under positive selection. The exponential growth rate (r), doubling time (Td) and R₀ were estimated to be 47.43 per year, 5.39 days and 2.72, respectively. Comparison of synapomorphies distinguishing the SARS-CoV-2 and the candidate ancestor bat coronavirus indicates that mutation pattern in nsp3 and S gene enabled the new strain to invade human and become a pandemic strain. We arrive at the following main conclusions: (i) six months evolution of viral genome is nearly neutral, (ii) origin of pandemic is not Wuhan and predates formal reports, (iii) although viral population is ongoing an exponential growth, the doubling time is evolving towards shortening, and (iv) divergence rate of total genome is similar to other RNA viruses, but it is prominently high in some genes while low in some others and evolution in these genes should be closely monitored as their protein products intervening to pathogenicity, virulence and immune response.

Preprint ARTICLE | doi:10.20944/preprints201804.0252.v1

Synergy in Knowledge-Based Innovation Systems at National and Regional Levels: The Triple Helix Model and the Fourth Industrial Revolution

Loet Leydesdorff

Subject: Social Sciences, Library And Information Sciences Keywords: triple helix; innovation systems; reflexive turn; expectation; synergy

Online: 19 April 2018 (11:28:35 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0559.v1

Fluid identification method and adaptability analysis of ultra-low porosity tight sandstone in Kuqa Depression, Tarim Basin

Maojin Tan, Chengwen Xiao, Chuang Han, Bo Li, Weiping Luo, Andong Wang, Qian Wang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Ultra-low porosity tight sandstone; fluid identification; NMR logging; triple-porosity comprehensive method; integrated method

Online: 26 August 2020 (04:22:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201712.0003.v1

Ventilation Positive Pressure Intervention Effect on IAQ in a School Building with Moisture Problems

Camilla Vornanen-Winqvist, Kati Järvi, Sander Toomla, Kaiser Ahmed, Maria A. Andersson, Raimo Mikkola, Tamas Marik, Laszlo Kredics, Heidi Salonen, Jarek Kurnitski

Subject: Engineering, Civil Engineering Keywords: ventilation; positive pressure; indoor air quality; mycobiota; indoor air questionnaire; moisture damage

Online: 1 December 2017 (07:06:04 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0546.v1

Atezolizumab and Pembrolizumab in Triple-Negative Breast Cancer: A Meta-Analysis

Mahwish Amin, Shaiza Sharif, Waleed Asghar, Humaira Sadaf, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs

Online: 24 May 2021 (09:23:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201803.0174.v1

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women

Tarun Mamidi, Jiande Wu, Paul B. Tchounwou, Lucio Miele, Chindo Hicks

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: gene expression obesity triple negative breast cancer

Online: 20 March 2018 (07:56:33 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201901.0323.v1

Triple Langmuir Probe for Diagnosis of Plasma Produced by Dielectric Barrier Discharge of Parallel Plates in Atmospheric Pressure

Ivan Alves de Souza, João Freire de Medeiros Neto, Antônia Karla Paixão Silveira, Thércio Henrique de carvalho Costa, Efrain Pantaleon Matamoros, Michelle Cequeira Feitor, Rômulo Ribeiro Magalhães Sousa

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: optical emission spectroscopy; Lissajous figures; triple Langmuir probe

Online: 31 January 2019 (07:36:09 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202101.0329.v1

From Shipbreaking Literature to Sustainability Framework for Developing Country Recycling: a Review (Part 2)

Sm Rahman

Subject: Engineering, Automotive Engineering Keywords: shipbreaking; triple bottom line sustainability; strange alliance; organizational learning

Online: 18 January 2021 (12:09:47 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202007.0206.v1

The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis

Askhat Myngbay, Limara Manarbek, Steve B. Ludbrook, Jeannette Kunz

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Collagen triple helix repeat containing 1; CTHRC1; rheumatoid arthritis; biomarker; bone erosion; cartilage destruction; fibroblast-like synoviocytes; Wnt signaling

Online: 10 July 2020 (07:51:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202204.0091.v1

Evidence-Based Evaluation of PCR Diagnostics for SARS-Cov-2 and The Omicron Variants by Sanger Sequencing

Sin Hang Lee

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; SARS-CoV; RT-PCR; Sanger sequencing; RT-qPCR; receptor-binding domain (RBD); N-terminal domain (NTD); Omicron; multi-allelic SNPs; false-positive

Online: 12 April 2022 (03:57:29 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202108.0053.v2

Protective Factors and Burnout Risk of Teachers During the COVID-19 Pandemic – A Two-Step Cluster Analysis

Camelia-Mădălina Răducu, Elena Stănculescu

Subject: Social Sciences, Psychology Keywords: COVID-19, positive emotionality, professional experience, selfcontrol, teacher burnout, well-being

Online: 26 October 2022 (09:37:02 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201709.0127.v2

A New Proof of Smoryński’s Theorem

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Logic Keywords: Davis-Putnan Robinson-Matiyasevich theorem; Diophantine equation which has at most finitely many solutions in non-negative integers; Diophantine equation which has at most finitely many solutions in positive integers; Diophantine equation which has at most finitely many integer solutions; Hilbert’s Tenth Problem; Matiyasevich’s theorem; recursively enumerable set; Smoryński’s theorem

Online: 27 September 2017 (04:05:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202107.0707.v1

Existential Suffering in Palliative Care: An Existential Positive Psychology Perspective

Paul T. P. Wong, Timothy T. F. Yu

Subject: Social Sciences, Psychology Keywords: Palliative care; Meaning therapy; CALM therapy; COVID-19; Existential positive psychology; Good death; wellbeing; mature happiness; flourishing

Online: 30 July 2021 (14:27:09 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201810.0010.v1

Revolution in Gene Medicine Therapy and Genome Therapy

David Jiang, Christine L. Xu, Stephen H. Tsang

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Gene therapy, gene editing, CRISPR/Cas9, Cas12a, dual AAV, triple AAV, clinical trials, retina, hereditary retinal dystrophies

Online: 1 October 2018 (13:52:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201902.0002.v1

Combining Blockchain Technology and the Physical Internet to Achieve Triple Bottom Line Sustainability: A Comprehensive Research Agenda for Modern Logistics and Supply Chain Management

Horst Treiblmaier

Subject: Computer Science And Mathematics, Computer Science Keywords: blockchain; distributed ledger technology; physical internet; logistics; supply chain management; research framework; innovation; information technology; triple bottom line; sustainability

Online: 1 February 2019 (04:00:54 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0368.v1

The Role of Perceived Social Support in the Psychological Well-Being of Young Offenders: from Pretrial Detention to Correctional Camps

Fedor Ushkov, Roman Shilko, Ludmila Shaigerova, Alexandra Dolgikh, Olga Almazova, Olga Vakhantseva, Yuri Zinchenko

Subject: Social Sciences, Psychology Keywords: psychological well-being; young offenders; social support; pretrial detention; correctional camps; positive and negative feelings; positive and negative affects

Online: 29 November 2019 (04:16:05 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201912.0121.v1

Project Management’s Triple Constraints Mapping on Augmented Reality based Learning System for Improved Quality

Mehreen Sirshar, Syeda Hafsa Ali, Haleema Sadia Baig

Subject: Engineering, Control And Systems Engineering Keywords: triple constraints; augmented reality; Augmented reality-based learning systems; time; cost; scope; artificial intelligence; education

Online: 9 December 2019 (09:17:17 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201909.0212.v1

Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

Tessa Nelemans, Marjolein Kikkert

Subject: Biology And Life Sciences, Virology Keywords: positive-sense single-stranded rna viruses; innate immune evasion; type 1 interferon; viral pathogenesis; type 3 interferon

Online: 18 September 2019 (17:12:01 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202008.0665.v1

Evolutionary Insights into the Envelope Protein of SARS-CoV-2

M. Shaminur Rahman, M. Nazmul Hoque, M. Rafiul Islam, Israt Islam, Israt Dilruba Mishu, Md. Mizanur Rahaman, Munawar Sultana, M. Anwar Hossain

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; envelop protein; mutations; transmembrane domain; triple cysteine motif

Online: 30 August 2020 (11:50:59 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201808.0408.v1

Effect of Cavity Vacuum Pressure Diminution on Thermal Performance of Triple Vacuum Glazing

Saim Memon, Farukh Farukh, Karthikeyan Kandan

Subject: Physical Sciences, Applied Physics Keywords: vacuum pressure; triple vacuum glazing; finite element modelling; thermal performance; towards zero-energy buildings

Online: 23 August 2018 (06:35:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202008.0632.v1

Mathematical Blockchain Modeling of Peer-to-Peer Networks for Gene Expression in Cell Population

Jung In Choi

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Blockchain; P2P Networks; Nucleobase DNA/RNA sequence; Gene Expression; Cell Population; Epigenetics; Methylation; Consensus; Hash Algorithm; Triple Codons; Protein Synthesis; Cryptocurrency

Online: 28 August 2020 (10:33:42 CEST)

Show abstract| Download PDF| Share

The study presents a mathematical modeling for supporting the premise that our body is composed of blockchain systems. A cell population is considered a space with peer-to-peer communication networks for applying blockchain protocol. Transaction is defined as gene expression that constantly occurs for protein synthesis in each cell. The transaction process proceeds according to the blockchain protocol with sharing and recording the data on the blockchain ledger. The premise comes from the clues of the previous research such that the cell population is a complex structured network system having cell-to-cell connections. Although individual cells exhibit stochastic nonlinear dynamic behavior, cell population shows consensus behavior that reaches to ensemble through interaction among cells. It is inferred that gene expression is not regulated by the corresponding cell only nor determined by external intelligence such as the brain. This is achieved through a consensus through stochastic interactions between cells over the whole cell population. These findings imply that mathematical blockchain modeling is a suitable for gene expression process. The original contribution of the study is a methodology for applying mathematically the blockchain protocol to the real biological gene expression process. In other words, the DNA sequence is converted into a numeral bit sequence that makes it possible to implement the blockchain protocol. A new DNA sequence scheme is proposed with adding methylated cytosine and adenine as the 5th and 6th bases for including epigenetic information which has profound effect on gene expression and regulation. The methodology was applied to the real biological synthesis process of protein samples. The protein is composed of amino acids that are encoded by triplet codons of 216 kinds with 6 base RNA sequence. The gene expression information is traced backward from a synthesized protein sample, amino acids of codons, RNA transcript up to DNA sequence. One of the results is a numeric value in the form of a bit sequence with which mathematical blockchain modeling is applicable. The cryptographic authentication and the consensus process are mathematically proven to work properly by the blockchain protocol. It implies that the same protein is synthesized, but with different epigenetic data, then protein's latent material properties will certainly be different. Although the result has not been justified by the biologic experiment yet, it is sure that the biological hidden algorithm inside DNA sequence will be revealed by the binary bit-logic with physical on/off states which is mathematically proven. The research will greatly contribute to disease treatment and medicine development as well as epigenetics in the future.

Preprint ARTICLE | doi:10.20944/preprints202208.0511.v1

Phytochemical Composition and Antibacterial Activity of Zingiber cassumunar Roxb. against Agricultural and Foodborne Pathogens

Maha A. Alshiekheid, Yheni Dwiningsih, Amal Abdullah Sabour, Jawaher Alkahtani

Subject: Biology And Life Sciences, Plant Sciences Keywords: Zingiber cassumunar Roxb.; essential oils; microencapsulated products; antibacterial activity; agricultural pathogens; foodborne pathogens; gram-positive bacteria; gram-negative bacteria

Online: 30 August 2022 (07:02:54 CEST)

Show abstract| Download PDF| Share

Zingiber cassumunar Roxb. is a powerful medicinal plant that has been used as traditional medicine to cure respiratory problems, pain, and inflammation in China, Indonesia, Thailand and other Asian countries by using the crude extracts. The objective of this research is to identify phytochemical composition of Z. cassumunar Roxb. and to analyze antibacterial activity of crude extract, purified compounds, and their microencapsulated products of Rhizome Z. cassumunar Roxb. Identification of phytochemical composition in crude extract of rhizome Z. cassumunar Roxb. was achieved by chromatography-mass spectrophotometer. The major phytochemical composition in crude extract of Z. cassumunar Roxb. is essential oils, including terpinen4-ol (37.7%), β-pinene (20.8%), and (E)-1-(3,4-dimethoxyphenyl)but-1-ene (13.3%). Crude extract of Z. cassumunar Roxb. was purified with silica gel flash column chromatography, resulting two purified compounds. The antibacterial activity of crude extract, purified compounds, and their microencapsulated products of Rhizome Z. cassumunar Roxb. were evaluated against agricultural and foodborne pathogens by using disc agar diffusion and broth microdilution techniques. All of the samples studied (crude extracts, purified compounds, and microencapsulated of Z. cassumunar Roxb.) were effective against all the bacteria. Based on the results of the disc-diffusion assay suggested that amongst the samples studied, purified compounds (compound 1 and 2) and microencapsulated purified compounds (compound 1 and 2) exhibited more effective against all the bacteria compared to the crude extracts. Antibacterial activity of the rhizome of Z. cassumunar Roxb. was contributed mainly by the essential oils components as the active compounds. Gram-negative bacteria (X. oryzae, X. translucens, Pseudomonas spp, E. coli, and S. typhimurium) appeared to the most resistant to the crude extracts, purified compounds, and microencapsulated of Z. cassumunar Roxb. compared to the gram-positive bacteria (S. aureus, B. cereus, and L. monocytogenes). Microencapsulated of the tested samples (crude extract, purified compound 1, and purified compound 2) of the rhizome Z. cassumunar Roxb. exhibited high antibacterial activity with no significantly different with the tested samples without microencapsulation. These results suggest potential antibacterial properties of Z. cassumunar Roxb., which useful for agricultural plant health, food preservation, natural therapies, and pharmaceuticals.

Preprint ARTICLE | doi:10.20944/preprints201809.0245.v1

On the Effect of Filling Rate on Positive Macrosegregation Patterns in Large Size Cast Steel Ingots

Chunping Zhang, Abdelhalim Loucif, Mohammad Jahazi, Rami Tremblay, Louis-Philippe Lapierre Boire

Subject: Engineering, Mechanical Engineering Keywords: medium-carbon low-alloy steel; large size ingot; hot-top; filling rate; positive macrosegregation

Online: 13 September 2018 (15:19:42 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201905.0126.v1

Viral strategies of manipulating autophagy to benefit infection

Ho Him Wong, Sumana Sanyal

Subject: Biology And Life Sciences, Virology Keywords: Autophagy; positive stranded RNA virus; proviral autophagy; viral subversion strategies

Online: 10 May 2019 (14:00:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0233.v1

Smart Homes and Families to Enable Sustainable Societies: A Data-Driven Approach for Multi-Perspective Parameter Discovery using BERT Modelling

Eman Alqahtani, Nourah Janbi, Sanaa Sharaf, Rashid Mehmood

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Smart Families; Smart Homes; Sustainable Societies; Smart Cities; Deep Learning; Natural Language Processing (NLP); Social Sustainability; Environmental Sustainability; Economic Sustainability; Bidirectional Encoder Representations from Transformers (BERT); Triple Bottom Line (TBL); Internet of Things (IoT)

Online: 12 August 2022 (10:22:17 CEST)

Show abstract| Download PDF| Share

Technological advancements and innovations have profoundly changed the lives of people giving rise to smart environments, cities, and societies. As homes are the building block of cities and societies, smart homes are critical to establishing smart living and are expected to play a key role in enabling smart cities and societies. The current academic literature and commercial advancements on smart homes have mainly focused on developing and providing smart functions for homes to provide security management and facilitate the residents in their various activities such as ambiance management. Homes are much more than physical structures, buildings, appliances, operational machines, and systems. Homes are composed of families and are inherently complex phenomena underlined by humans and their relationships with each other, subject to individual, intragroup, intergroup, and intercommunity goals. There is a clear need to understand, define, consolidate existing research, and actualize the overarching roles of smart homes, the roles of smart homes that would serve the needs of future smart cities and societies. This paper introduces our data-driven parameter discovery methodology and uses it to provide, for the first time, an extensive, rather fairly comprehensive, analysis of the families and homes landscape seen through the eyes of academics and the public using over a hundred thousand research papers and nearly a million tweets. We develop a methodology using deep learning, natural language processing (NLP), and big data analytics methods and apply it to automatically discover parameters that capture a comprehensive knowledge and design space of smart families and homes comprising social, political, economic, environmental, and other dimensions. The 66 discovered parameters and the knowledge space comprising 100s of dimensions are explained by reviewing and referencing over 300 articles from the academic literature and tweets. The knowledge and parameters discovered in this paper can be used to develop a holistic understanding of matters related to families and homes facilitating the development of better, community-specific, policies, technologies, solutions, and industries for families and homes, leading to strengthening families and homes, and in turn, empowering sustainable societies across the globe.

Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202206.0023.v1

Innate Health: A Novel Examination of What Explains Well-being, Prosocial Behavior, and Aggression among Men Living in a UK Prison

Jeanne Catherine, Adriaan Denkers, Anita McGinty

Subject: Social Sciences, Psychology Keywords: well-being; innate health; positive psychology; mental health; three principles; self-control; pro-social behaviors; criminology; incarcerated men; prisoners; inmates

Online: 2 June 2022 (02:57:49 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202107.0614.v1

Mixed Effects and Mechanisms of Cannabinoids for Triple-Negative Breast Cancer Treatment

Khanh Tran

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Triple-negative breast cancer; cannabinoid; marijuana; cell signalling; medicinal plants

Online: 28 July 2021 (08:56:32 CEST)

Show abstract| Download PDF| Share

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the lack of estrogen receptors (ER), progesterone receptors, and HER-2 receptors. Thus, TNBC tumours do not benefit from the current therapies targeting ER or HER-2. Therefore, there is an urgent need to develop novel treatment for this subtype of breast cancer. Marijuana is a common name given to Cannabis plants, a group of plants in the Cannabis genus of the Cannabaceae family. Cannabis plants are among the oldest cultivated crops, traced back at least 12,000 years and are well known for their multi-purpose usage, including medicinal purposes. The main active compounds extracted from Cannabis plants are 21-carbon-containing terpenophenolics, which are referred to as phytocannabinoids. Of these, the tetrahydrocannabinol (THC) group contains highly potent cannabinoids, including delta-9-tetrahydrocannabinol (∆9-THC) and delta-8-tetrahydrocannabinol (∆8-THC), which are the most abundant THCs and are largely responsible for psychological and physiological effects of marijuana. The use of Cannabis plants for medicinal purposes was first recorded in 2337 BC in China, where Cannabis plants were used to treat pains, rheumatism, and gout. Recently, several cannabinoids have been approved for a number of treatments, one of which is the treatment of nausea and vomiting caused by chemotherapy in cancer patients. Furthermore, increasing evidence shows that cannabinoids not only attenuate side effects due to cancer treatment, but might also potentially possess direct antitumor effects in several cancer types, including breast cancer. However, anti-tumour activity of marijuana has been variable in different studies and even promoted tumour growth in some cases. In addition, the mechanisms of cannabinoid action in cancer remain unclear. This review summarizes evidence about the mixed actions of cannabinoids in cancer in general and triple-negative breast cancer in particular.

Preprint ARTICLE | doi:10.20944/preprints202206.0108.v1

Neuropsychological Findings in Adults with Triple X Syndrome

Maarten Otter, Bea Campforts, Connie TRM Stumpel, Thérèse Van Amelsvoort, Claudia Vingerhoets, Marjan Drukker

Subject: Social Sciences, Cognitive Science Keywords: Triple X syndrome; Adults; Neurocognitive functioning; Sex Chromosomal Disorders; Attention; Psychomotor speed; Executive functioning

Online: 7 June 2022 (11:26:18 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201908.0225.v1

Analysis of Water Bodies under Partial Cloud Conditions Using Satellite Images

Rahul Neware, Mansi Thakare

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: water bodies; satellite images; vector data; SVM; positive and negative buffering; polygons

Online: 21 August 2019 (10:30:16 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202004.0226.v2

The Non-Tragedy of the Non-Linear Commons

Marco Archetti, István Scheuring, Douglas Yu

Subject: Biology And Life Sciences, Other Keywords: positive assortment; public goods; collective action; common-pool resources; cooperation; game theory; group selection; kin selection; social dilemma

Online: 16 June 2020 (12:35:40 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201807.0305.v1

Influence of Congruency between Ideal Self and Brand Image on Sustainable Happiness

Jeongsoo Han, Mina Jun, Miyea Kim, Sookyoung Key

Subject: Business, Economics And Management, Marketing Keywords: sustainable happiness; ideal self; ideal social self; brand identification; positive

Online: 17 July 2018 (10:39:58 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202105.0496.v2

An Explanation and Understanding of Aerodynamic Lift by Triple Deck Theory

Alois Schaffarczyk

Subject: Engineering, Mechanical Engineering Keywords: Aerodynamic Lift; Boundary Layer Theory; Triple Deck Theory

Online: 9 November 2021 (14:52:31 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201910.0213.v1

Quasi Cubic Trigonometric Curve and Surface

Guicang Zhang, Kai Wang

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Quasi Extended Chebyshev space; optimal normalized totally positive basis; high-order continuity; shape preserving; shape features

Online: 18 October 2019 (11:33:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201812.0314.v1

From Individual Resource to Social Capital: The Mechanism of How Political Skill Affect Job Satisfaction and Turnover Intention

Yi Li, Mengqiu Ma

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: political skill; job satisfaction; turnover intention; popularity; positive affect; negative affect

Online: 26 December 2018 (12:16:31 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0085.v1

Chick Embryo Experimental Platform for 3D Tissue Engineering Modelling of Cancer Micrometastases for Tumor Biology, Drug Development and Nanomaterials Testing

Anna Guller, Inga Kuschnerus, Vlada Rozova, Annemarie Nadort, Yin Yao, Zahra Khabir, Alfonso Garcia-Bennett, Liuen (Olivia) Liang, Aleksandra Polikarpova, Yi Qian, Ewa M. Goldys, Andrei Zvyagin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chick embryo; 3D culture; tumor models in vitro; tissue engineering; metastasis; triple-negative breast cancer; liver; mesoporous silica nanoparticles; doxorubicin; micrometastasis

Online: 6 September 2021 (11:46:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0817.v1

Spontaneous Self-Affirmation and Student-Specific Stress: Relationships with Overlapping Constructs of Positive Self Regard During the COVID-19 Pandemic

Anna Nicklin, Jim Morgan

Subject: Social Sciences, Psychology Keywords: spontaneous self-affirmation; student stress; habitual positive self-thought; self-esteem; self-integrity; self-affirmation

Online: 12 July 2023 (12:05:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0094.v3

“Clinician’s Probability Calculator” to Convert Pre-Test to Post-Test Probability of COVID-19, Based on Method Validation from Each Laboratory

Zoe Brooks, Saswati Das, Tom Pliura

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-COV-2; False-Positive; False-Negative; Likelihood Ratio; Probability; Calculator; Interpretation

Online: 3 March 2021 (10:08:27 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201807.0224.v2

Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha

Julia Sperlich, Nicole Teusch

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: pseudopterosin; triple negative breast cancer; glucocorticoid receptor alpha; dexamethasone; cell proliferation; 3D invasion; tumor spheroid; co-culture; interleukin 6; interleukin 8

Online: 2 August 2018 (06:08:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0784.v1

Artificial Compassion—From An AI Scholar

Cindy Mason

Subject: Social Sciences, Anthropology Keywords: Artificial Intelligence, Robots, Compassion, Human Sciences, Positive Plasticity

Online: 30 April 2021 (10:36:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201908.0059.v1

The Effect of Recreation in a Snow-Covered Forest Environment on the Psychological Relaxation of Young Females

Ernest Bielinis, Adrian Łukowski, Aneta Omelan, Sergii Boiko, Norimasa Takayama

Subject: Biology And Life Sciences, Forestry Keywords: deciduous forest; female; forest bathing; forest therapy; Positive and Negative Affect Schedule; Profile of Mood States; Restorative Outcome Scale; restoration; Shinrin-Yoku; snow covered forest; Subjective Vitality Scale; winter

Online: 5 August 2019 (08:56:32 CEST)

Show abstract| Download PDF| Share

Forest recreation can be successfully conducted for the purpose of psychological relaxation, as has been proven in previous scientific studies. During the winter in many countries, when snow cover occurs frequently, forest recreation (walking, relaxation, photography, etc.) is common. Nevertheless, whether forest therapy conducted in a forest environment with a snow cover will also have a positive effect on psychological indicators remains unknown. Furthermore, male subjects frequently participate in forest therapy experiments, whereas females are rarely involved. Thus, in this study, the effectuality of forest recreation during winter and with snow cover was tested on 32 young females. For these reasons, the experiment involved 15-minute periods of relaxation in a forest environment or in an urban environment, in addition to a pre-test under indoor conditions. Four psychological questionnaires (POMS, PANAS, ROS, SVS) were administered to participants before and after interventions. Results showed that participants’ levels of negative mood, as measured by different aspects of the POMS questionnaire (tension-anxiety, anger-hostility, depression-dejection, confusion, fatigue), decreased after exposure to the forest environment. In contrast, both tension-anxiety and anger-hostility increased in the urban environment. The indicator of negative affect from the PANAS questionnaire also increased after exposure to the urban environment, whereas the indicator of positive affect based on PANAS was higher in the forest environment than in the urban environment. Restorativeness and subjective vitality exhibited higher values after exposure to the forest environment in comparison to those from the control and pre-test. The changes in these indicators demonstrates that forest recreation in the snow during winter can significantly increase psychological relaxation in young females, as well as showing that recreation can be successfully conducted under these winter conditions.

Preprint ARTICLE | doi:10.20944/preprints201810.0619.v1

Gas Hydrate Estimate in an Area of Deformation and High Heat Flow at the Chile Triple Junction

Lucía Villar-Muñoz, Iván Vargas-Cordero, Joaquim P. Bento, Umberta Tinivella, Francisco Fernandoy, Michela Giustiniani, Jan H. Behrmann, Sergio Calderon-Diaz

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: BSR; gas hydrate; methane; seepage; active margin; Chile Triple Junction

Online: 26 October 2018 (06:18:51 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints201911.0214.v1

Unbiasing in the Genome Analysis of Iconic Shark Species

Kazuaki Yamaguchi, Shigehiro Kuraku

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: shark; genome; longevity; gigantism; positive selection

Online: 18 November 2019 (07:46:50 CET)

Show abstract| Download PDF| Share

Working Paper BRIEF REPORT

Positive Rate Is Useful to Evaluate the Sufficiency of RT-PCR Test Availability for COVID-19

Sadao Suzuki

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; RT-PCR test; pre-test probability; positive rate

Online: 5 May 2020 (06:04:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0133.v1

Phenotypic Heterogeneity Drives Differential Disease Outcome in Triple Negative Breast Cancer

Archana P. Thankamony, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Radhika Nair

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Intratumoral heterogeneity; Triple negative breast cancer (TNBC); Macc1; Phenotypic heteroge-neity

Online: 9 February 2022 (10:40:54 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202201.0012.v3

Quantifying Nature Positive

Anna-Mieke Mathilde Vlieg, Shadia Moazzem, Direshni Naiker, Delwyn Gloria Jones

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Nature-Positive; Quantified Benefit Assessment; Security; Wellness; Viability; Gain

Online: 21 April 2022 (17:37:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202204.0314.v1

The Coronavirus Disease 2019 Spatial Care Path: Home, Community, and Emergency Diagnostic Portals

Gerald J. Kost

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Emergency Use Authorization; endemic; false omission; false omission rate; home testing; point-of-care testing (POCT); positive predictive value geometric mean-squared; prevalence boundary; recursive protocol; tier; visual logistics

Online: 30 April 2022 (08:42:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202108.0129.v1

A Phase-Field Perspective on Mereotopology

Georg J. Schmitz

Subject: Physical Sciences, Mathematical Physics Keywords: Region based theory of space; RBTS; Contact algebra; Dyadic and Triadic relations; sequent algebra; boundaries; triple junctions; mereotopology; 4D mereotopology; mereophysics; Region Connect Calculus RCC; invariant spacetime interval; Falaco solitons; phase-field method; intuitionistic logic

Online: 5 August 2021 (08:39:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0357.v1

From Deficit to Strength-Based Aboriginal Health Research – Learning from those Who Flourish

Jonathan Bullen, Trish Hill-Wall, Kate Anderson, Alex Brown, Clint Bracknell, Elizabeth A. Newnham, Gail Garvey, Lea Waters

Subject: Social Sciences, Psychology Keywords: Aboriginal; First Nations; wellbeing; salutogenesis; flourishing; positive psychology; complex systems

Online: 21 February 2023 (09:09:23 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201909.0027.v1

Comparison of Smallest Eigenvalues for Nabla Fractional Boundary Value Problems

Jagan Mohan Jonnalagadda

Subject: Computer Science And Mathematics, Analysis Keywords: nabla fractional difference; boundary value problem; cone; u0- positive operator; eigenvalue

Online: 3 September 2019 (00:38:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0083.v1

Is the Higgs Field a Positive and Negative Mass Planckion Condensate, and Does the LHC Produce Extreme Dark Energy?

Christopher Pilot

Subject: Physical Sciences, Particle And Field Physics Keywords: Winterberg Model; Quantum Vacuum; Higgs Condensate/Composite Model; Two-Component Superfluid/Supersolid Model for the Vacuum; Positive/Negative Planckion Mass, Q-Theory; Non- Linear Heisenberg Spinor Theory; LHC Energies, Dark Energy; Lattice Substructure for Space

Online: 6 September 2021 (10:38:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0055.v1

Semi-Covariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and other Coronaviruses for Viral Evolution and Characteristics Associated with Fatality

Jun Huang, Rebecca Spencer, Wangdong Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Fractional complex moment; SARS-CoV-2; coronaviruses; spike protein sequence; Pearson correlation coefficient; semi-covariance coefficient; positive-correlative and negative-correlative domains

Online: 2 March 2021 (09:30:12 CET)

Show abstract| Download PDF| Share

Complex modeling has received significant attention in recent years and is increasingly used to explain the statistical phenomenon with increasing and decreasing fluctuations such as the similarity or difference of spike protein charge patterns of coronaviruses. Different from the existing covariance or correlation coefficient methods in traditional integer dimension construction, this study proposes a simplified novel fractional dimension derivation with the exact Excel tool algorithm. It involves the fractional center moment extension to covariance, which ends up a complex covariance coefficient that is better than the Pearson correlation coefficient, in the sense that the nonlinearity relationship can be further depicted. The spike protein sequences of coronaviruses were obtained from the GenBank and GISAID database, including the coronaviruses from pangolin, bat, canine, swine (three variants), feline, tiger, SARS-CoV-1, MERS, and SARS-CoV-2 (including the strains of Wuhan, Beijing, New York, German, and UK variant B.1.1.7) were used as the representative examples in this study. By examining the values above and below the average/mean based on the positive and negative charge patterns of the amino acid residues of the spike proteins from coronaviruses, the proposed algorithm provides deep insights into the nonlinear evolving trends of spike proteins for understanding the viral evolution and identifying the protein characteristics associated with viral fatality. The calculation results demonstrate that the complex covariance coefficient analyzed by this algorithm is capable of distinguishing the subtle nonlinear differences in the spike protein charge patterns with reference to Wuhan strain SARS-CoV-2 for which the Pearson correlation coefficient may overlook. Our analysis reveals the unique convergent (positive correlative) to divergent (negative correlative) domain center positions of each virus. The convergent or conserved region may be critical to the viral stability or viability; while the divergent region is highly variable between coronaviruses suggesting high frequency of mutations in this region. The analyses show that the conserved center region of SARS-CoV-1 spike protein is located at amino acid residues 900, but shifted to the amino acid residues 700 in MERS spike protein, and then to amino acid residues 600 in SARS-COV-2 spike protein, indicating the evolvement of the coronaviruses. Interestingly, the conserved center region of the spike protein in SARS-COV-2 variant B.1.1.7 shifted back to amino acid residues 700, suggesting this variant is more virulent than the original SARS-COV-2 strain. Another important characteristic our study reveals is that the distance between the divergent mean and the maximal divergent point in each of the viruses (MERS>SARS-CoV-1>SARS-CoV-2) is proportional to viral fatality rate. This algorithm may help to understand and analyze the evolving trends and critical characteristics of SARS-COV-2 variants, other coronaviral proteins and viruses.

Preprint REVIEW | doi:10.20944/preprints201901.0039.v1

Prevention of Hearing Loss by Alteration of the Systemic Immune System

Hiroshi Iwai, Muneo Inaba

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: autoimmune sensorineural hearing loss; age-related sensorineural hearing loss; inflammation, immune senescence; interleukin 1 receptor type II -positive T cells; naturally occurring regulatory T cells; immune rejuvenation; thymus

Online: 4 January 2019 (11:37:31 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0152.v1

Can The Advantages Of Video Assisted Thoracoscopic Lobectomy Be Reproduced In A Low Volume Center?

Shagufta Shaheen, Salman Otoukesh, Brice Jabo, Manmeet Kaur, Nicole Wheeler, Said Mirshahidi, Salman Zaheer, Hamid R. Mirshahidi

Subject: Medicine And Pharmacology, Surgery Keywords: video assisted thoracic surgery, open thoracotomy, recurrence-free survival, overall survival, positive margins, postoperative length of stay.

Online: 8 October 2018 (15:23:21 CEST)

Show abstract| Download PDF| Share

Background: Video assisted thoracoscopic surgery (VATS) has become the recommended approach for treatment of resectable lung cancer. However, no large randomized clinical trial has been conducted formally comparing surgical resections completed by VATS to those done by open thoracotomy (OT) in low volume centers. The current study sought to assess differences in recurrence-free survival (RFS), overall survival (OS), positive margins and postoperative length of stay (LOS) between VATS and OT lobectomies in our center. Method: A single institution retrospective chart review from May 2005 through May 2015 was conducted. All patients diagnosed with stage I through III lung cancer who underwent surgical resection were selected. Patient and tumor characteristics recorded included age at diagnosis, sex, tobacco use, tumor location (side and lobe), stage, size and receipt of chemotherapy or radiotherapy. Chis-square and Wilcoxon-Mann-Whitney tests were used to compare demographics, tumor characteristics and LOS. Multiple logistic and Cox regression analyses were used to compute relative risk (RR) for positive margins and mortality hazard ratios along with 95 percent confidence intervals (95%CI), respectively. Results: Of the 235 patients, 101 subjects had VATS while OT was performed in 134 patients. Age at diagnosis, sex, tobacco use, tumor location, and size were comparable for VATS and OT. No significant difference was observed in the relative risk of positive margins for VATS versus OT, RR = 0.56 (95%CI = 0.26, 1.05). However, VATS had shorter median LOS compared to OT (4 vs. 6 days, respectively), p = 0.002. A comparison of VATS versus OT showed no significant difference in the risk of recurrence, HR = 1.21 (95%CI = 0.74, 2.00), or death, HR = 1.34 (95%CI = 0.88, 2.06), in the intent-to-treat population. Similarly, no significant differences in recurrence or mortality risk were observed between VATS versus OT for analyses conducted separately for each cancer stage group or those limited to patients with negative margins. Conclusion: Our study indicates that compared to OT, VATS leads to shorter LOS while achieving comparable margins status, recurrence-free and overall survival regardless of tumor stage at diagnosis.

Preprint ARTICLE | doi:10.20944/preprints202005.0014.v1

Participating in HIV Prevention Clinical Trial: Reasons and Experiences among Female Participants in Antibody Mediated Prevention Study at UNC Project, Lilongwe, Malawi

Ruth Holla, Adamson Muula

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: HIV/AIDS; community health worker; clinical trial; informed consent; HIV positive; STI

Online: 2 May 2020 (13:45:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202201.0081.v1

Recrystallization of Triple Superphosphate Produced From Oyster Shell Waste for Agronomic Performance and Environmental Issue

Somkiat Seesanong, Chaowared Seangarun, Banjong Boonchom, Chuchai Sronsri, Nongnuch Laohavisuti, Kittichai Chaiseeda, Wimonmat Boonmee

Subject: Chemistry And Materials Science, Biomaterials Keywords: Ca(H2PO4)2·H2O; Triple superphosphate; Fertilizer; Recrystallization; Oyster shell; Thermal decomposition

Online: 6 January 2022 (11:48:24 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0367.v1

A Kirkpatrick Model Process Evaluation of Reactions and Learning from My Strengths Training for Life™

Mary L. Quinton, Grace Tidmarsh, Benjamin J. Parry, Jennifer Cumming

Subject: Social Sciences, Psychology Keywords: young people experiencing homelessness; disadvantaged youth; engagement; community-based research; positive youth development; mental skills training

Online: 22 August 2022 (03:25:19 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201809.0595.v1

Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives

Gabriela Garrastazu Pereira, Tristan Rawling, Michele Pozzoli, Curtis Pazderka, Yongjuan Chen, Colin R. Dunstan, Michael Murray, Fabio Sonvico

Subject: Chemistry And Materials Science, Nanotechnology Keywords: nanoemulsion; oral delivery; ω-3 polyunsaturated fatty acid derivative; MDA-MB-231; triple-negative breast cancer

Online: 30 September 2018 (05:14:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0041.v1

The Oxygen Desaturation Measured by Optical Sensor at Fingertip but Not at the Arm Is Diminished by Continuous Positive Airway Pressure in Obstructive Sleep Apnea

Zhongxing Zhang, Ming Qi, Gordana Hügli, Ramin Khatami

Subject: Medicine And Pharmacology, Other Keywords: Obstructive sleep apnea; Continuous positive airways pressure therapy; Near-infrared spectroscopy; Oxygen desaturation; Arm; Pulse oximeter

Online: 2 November 2021 (10:52:45 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0178.v1

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Melissa Davis, Rachel Martini, Lisa Newman, Olivier Elemento, Jason White, Akanksha Verma, Indrani Datta, Indra Adrianto, Kevin Gardner, Hyung-Gyoon Kim, Windy Dean-Colomb, Isam Eldin Eltoum, Andra R Frost, William E. Grizzle, Andrea Sboner, Upender Manne, Clayton Yates

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; African Ancestry; RNAseq analysis; oncologic pathways

Online: 12 April 2020 (04:22:51 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201912.0177.v1

The Akimotoite--Majorite--Bridgmanite Triple Point Determined in Large Volume Press and Laser-Heated Diamond Anvil Cell

Britany Kulka, Jonathan Dolinschi, Kurt Leinenweber, Vitali Prakapenka, Sang-Heon Shim

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: triple point; bridgmanite; akimotoite; majorite; large-volume press; laser-heated diamond anvil cell

Online: 12 December 2019 (12:47:47 CET)

Show abstract| Download PDF| Share

Preprint HYPOTHESIS | doi:10.20944/preprints202003.0021.v2

Bottleneck, Isolate, Amplify, Select (BIAS) as a Mechanistic Framework for Intracellular Population Dynamics of Positive Sense RNA Viruses

Feng Qu, Limin Zheng, Shaoyan Zhang, Rong Sun, Jason Slot, Miyashita Shuhei

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: virus; population bottleneck; positive sense RNA virus; evolution

Online: 1 October 2020 (08:28:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0158.v1

Thickness Optimization of Thin-Film Tandem Organic Solar Cell

Kamran Ali Bangash, Syed Asfandyar Ali Kazmi, Waqas Farooq, Saba Ayub, Muhammad Ali Musarat, Wesam Salah Alaloul, Muhammad Faisal Javed, Amir Mosavi

Subject: Computer Science And Mathematics, Computer Science Keywords: Organic Solar Cells; Triple Junction; Tandem, Energy Harvesting; Temperature.

Online: 6 April 2021 (09:21:56 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202212.0380.v1

Li-Rich Layered Oxides: Structure and Doping Strategies to Enable Co-poor/Co-free Cathodes for Li-Ion Batteries

Laura Silvestri, Mariarosaria Tuccillo, Arcangelo Celeste, Sergio Brutti

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: lithium rich layered oxides; secondary aprotic batteries; positive electrode materials; Li-ion; cathodes.

Online: 21 December 2022 (03:36:22 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0439.v1

One Possible Reinfection with SARS-CoV-2 Validated by 205-days Interval of Re-detection in Sapporo City, Japan

Toshiaki Asakura, Akiko Tamakoshi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; reinfection; re-detected positive; Japan

Online: 16 April 2021 (11:09:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0777.v1

Prediction of Response to Atezolizumab Plus Nab-Paclitaxel in Unresectable Locally Advanced Triple Negative Breast Cancer (TNBC): the ClinicalUsefulness of PD-L1 mRNA Expression in Plasma-Derived Exosomes

Lucrezia Raimondi, Gian Paolo Spinelli, Paolo Ciracì, Filippo Maria Raimondi, Rachele Lazzeroni, Laura Di Benedetto, Stefano Valabrega, Laura Giaconi, Luigi Rossi, Giuseppe Naso

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Exosomal PD-L1 mRNA; extracellular vesicles; Triple Negative Breast Cancer; Immunotherapy; PD-L1 axis; Atezolizumab – nab-paclitaxel; Predictive biomarkers; Liquid biopsy

Online: 31 March 2021 (15:27:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0216.v1

The Impact of Research and Development Expenditures on ESG Model in the Global Economy

Alberto Costantiello, Angelo Leogrande

Subject: Business, Economics And Management, Economics Keywords: Analysis of Collective Decision-Making; General; Political Processes: Rent-Seeking; Lobbying; Elections; Legislatures; and Voting Behaviour; Bureaucracy; Administrative Processes in Public Organizations; Corruption; Positive Analysis of Policy Formulation; Implementation

Online: 11 April 2023 (08:53:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0120.v1

Too Committed to Switch off – Capturing and Organizing the Full Range of Work-Related Rumination from Detachment to Overcommitment

Oliver Weigelt, J. Charlotte Seidel, Lucy Erber, Johannes Wendsche, Yasemin Z. Varol, Gerald M. Weiher, Petra Gierer, Claudia Sciannimanica, Richard Janzen, Christine J. Syrek

Subject: Social Sciences, Psychology Keywords: work-related rumination; overcommitment; psychological detachment; burnout; irritation; problem-solving pondering; positive work reflection; negative work reflection; affective rumination; satisfaction with life

Online: 6 January 2023 (09:36:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0041.v1

Employee Well-being in the Perspective of Positive Psychology and of the Job Demands-Resources Theory. The Role of Trust Within the Organization

Agnieszka Czerw, Damian Grabowski, Agata Chudzicka-Czupała, Katarzyna Stapor, Marta Żywiołek-Szeja

Subject: Social Sciences, Psychology Keywords: Well-being; Positive psychology; Organizational psychology; Job demands-resources

Online: 2 March 2023 (10:20:13 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202206.0323.v1

A Novel Triple Radar Arrangement for Level 2 ADAS Detection System in Autonomous Vehicles

Javad Enayati, Pedram Asef, Yeshwanth Jonnalagadda

Subject: Engineering, Electrical And Electronic Engineering Keywords: Autonomous vehicles, triple radar, Level 2 ADAS system, lane keeping assistance, nonlinear model predictive controller, safety, autonomous emergency braking.

Online: 23 June 2022 (10:36:09 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Turkish Adaptation of the Positive-Negative Relationship Quality (PN-RQ) Scale: A Reliability and Validity Study

Arzu Araz, Duygu Güngör, Eda Aşçı

Subject: Social Sciences, Psychology Keywords: positive-negative relationship quality; reliability; validity; confirmatory factor analysis (CFA); bifactor

Online: 16 September 2019 (16:33:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0491.v1

Cross-Sectional Study on Relationships Among FoMO, Social Influence, Positive Outcome Expectancy, Refusal Self-Efficacy and SNS Usage

KUNHUA LEE, Chia-Yu Lin, Jing Tsao, Lien Fang Hsieh

Subject: Social Sciences, Psychology Keywords: FoMO; Social Cognitive Theory; Social Influence; Self-efficacy; Positive Outcome Expectancy

Online: 21 July 2020 (12:57:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0399.v1

Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer

Emilio Guillén-Mancina, Julio José Jiménez-Alonso, José Manuel Calderón-Montaño, Víctor Jiménez-González, Patricia Díaz-Ortega, Estefanía Burgos-Morón, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Amino acids, lipids, diet, low-fat diet, cancer therapy, cancer metabolism, triple-negative breast cancer, lung cancer, melanoma, colorectal cancer, ovarian cancer, metastasis

Online: 21 December 2022 (10:05:50 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0322.v1

Replication-Dependent Biogenesis of Turnip Crinkle Virus Long Noncoding RNAs

Shaoyan Zhang, Rong Sun, Limin Zheng, Feng Qu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Virus; plant virus; long noncoding RNA; replication; positive sense RNA virus

Online: 14 May 2021 (11:01:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0515.v1

Positive Adult Education Learned Helplessness and the Pygmalion Effect

David Cobos-Sanchiz, Manuel-Jesús Perea-Rodriguez, Juan-Agustín Morón-Marchena, María-Carmen Muñoz-Díaz

Subject: Social Sciences, Education Keywords: Positive education; Pygmalion effect; learned helplessness; lifelong education; adult education

Online: 29 November 2021 (07:52:15 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0437.v1

Differences in Psychological Vulnerability, Mental Health Liter-Acy, Positive Mental Health, and Health Behaviours in Portu-Guese Higher Education Students: A Cross-Sectional Study

Maria José Nogueira, José Carlos Carvalho, Patrício Soares Costa, Carlos Alberto Sequeira

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: nursing health promotion; literacy; positive mental health; psychological vulnerability; students

Online: 27 March 2023 (03:34:45 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer

Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader El-Sayes, Karen Mossman, John Valliant

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; immunotherapy; immune checkpoint therapy; radionuclide therapy

Online: 9 April 2021 (13:26:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0276.v1

An Analysis of the Entrepreneurial University in the Faculties of Education in Spain: Self-perception among Deans

Jessica Paños-Castro, Leire Markuerkiaga, María José Bezanilla

Subject: Social Sciences, Education Keywords: entrepreneurial university; entrepreneurship; faculties of education; self-perception; triple helix; third mission; teacher training.

Online: 16 September 2021 (11:03:53 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202112.0121.v1

Agent-Based Modelling of Urban District Energy System Decarbonisation – A Systematic Literature Review

Ardak Akhatova, Lukas Kranzl, Fabian Schipfer, Charitha Buddhika Heendeniya

Subject: Social Sciences, Geography, Planning And Development Keywords: agent-based modelling; agent-based simulation; urban energy system; district energy system; systematic literature review; net-zero energy district; positive energy district

Online: 8 December 2021 (12:06:02 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1601.v1

Antimicrobial Potential of the Microalgae Extracts

Alexander Lykov, Alexei Salmin, Ruslan Gevorgiz, Svetlana Zheleznova, Lyubov Rachkovskaya, Maria Surovtseva, Olga Poveshchenko

Subject: Biology And Life Sciences, Life Sciences Keywords: diatoms; cyanobacter; green microalgae; Gram-positive and Gram-negative bacteria; Mycobacteria; antimicrobial potential

Online: 24 July 2023 (10:46:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0114.v1

Frequency-Shift of Quartz Crystal Microbalance Depends on the Length of Actin Filaments

Naoki Matsumoto, Honoka Kobayashi, Taiki Nishimura, Hideki Ashizawa, Takashi Kuwahara, Hajime Honda, Ikuko Fujiwara

Subject: Engineering, Bioengineering Keywords: quartz crystal microbalance; actin; positive frequency shift; physical property; biomolecule

Online: 3 May 2023 (08:14:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0527.v1

Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells

Andrew Sulaiman, Sarah McGarry, Jason Chambers, Emil Al-Kadi, Alexandra Phan, Li Li, Karan Mediratta, Jim Dimitroulakos, Christina Addison, Xuguang Li, Lisheng Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; Hypoxia; EGFR; Cisplatin; PDX

Online: 22 July 2020 (11:32:30 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0030.v1

The Role of Political Stability in the Context of ESG Models at World Level

Alberto Costantiello, Angelo Leogrande

Subject: Business, Economics And Management, Economics Keywords: Analysis of Collective Decision-Making; General; Political Processes; Rent-Seeking; Lobbying; Elections; Legislatures; Voting Behaviour; Bureaucracy; Administrative Processes in Public Organizations; Corruption; Positive Analysis of Policy Formulation; Implementation

Online: 3 April 2023 (14:36:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0747.v1

Existential Wellbeing in Palliative Care: A Paradigm of Existential Positive Psychology

Paul T. P. Wong, Richard G. Cowden, Timothy T. F. Yu, Gökmen Arslan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Existential wellbeing; Spiritual wellbeing; Meaningful suffering; Suffering; Tragic Optimism; Self-transcendence; Death; Dying; Existential Positive Psychology

Online: 9 January 2024 (15:48:35 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1498.v1

Self-Directed Online Learning in Support of Mental Health to Promote Positive Psychosocial Outcomes in Public Schools

Carol Nash

Subject: Social Sciences, Psychiatry And Mental Health Keywords: mental health; public schooling; self-directed learning; standardized learning; positive psychosocial outcomes; John Dewey; COVID-19; online learning; Google Scholar

Online: 21 June 2023 (09:33:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202201.0164.v1

Neoadjuvant Pertuzumab plus Trastuzumab in Combination with Docetaxel and Carboplatin in Patients with HER2 Positive Breast Cancer: Real-World Data from a National Institute of Oncology in Poland.

Agnieszka Irena Jagiełło-Gruszfeld, Magdalena Rosinska, Malgorzata Meluch, Katarzyna Pogoda, Anna Niwińska, Renata Sienkiewicz, Aleksander Grous, Pawel Winter, Zbigniew I. Nowecki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer,; neoadjuvant chemotherapy; elederly; HER2- positive; pathological complete response; safety

Online: 12 January 2022 (13:31:16 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202208.0431.v1

Management of Bladder Cancer Patients with Clinical Evidence of Lymph Node Invasion (cN+)

Bartosz Małkiewicz, Adam Gurwin, Jakub Karwacki, Krystian Nagi, Klaudia Knecht-Gurwin, Krzysztof Hober, Magdalena Łyko, Kamil Kowalczyk, Wojciech Krajewski, Anna Kołodziej, Tomasz Szydełko

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: bladder cancer; clinically positive lymph nodes; diagnosis; treatment; lymphadenectomy

Online: 25 August 2022 (10:05:05 CEST)

Show abstract| Download PDF| Share

Search Results

221 articles found