Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Unbiasing in the Genome Analysis of Iconic Shark Species

Version 1 : Received: 11 November 2019 / Approved: 18 November 2019 / Online: 18 November 2019 (07:46:50 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: Frontiers in Marine Sciences 2021
DOI: 10.3389/fmars.2021.573853


A previous study involving whole genome sequencing of the white shark suggested unique molecular evolution accounting for gigantism and the enhanced longevity of sharks including positive selection of dozens of protein-coding genes potentially involved in genome stability. We performed a reanalysis on some of the genes and identified serious flaws in their results. In this short article, we scrutinize one of the serious problems we identified, report other concerns, and point out a potential bias in analyzing iconic shark species in general.

Supplementary and Associated Material The authors' publication covering non-iconic shark species


shark; genome; longevity; gigantism; positive selection


BIOLOGY, Animal Sciences & Zoology

Comments (1)

Comment 1
Received: 18 November 2019
Commenter: Shigehiro Kuraku
The commenter has declared there is no conflict of interests.
Comment: I welcome any opinions and comments on the original PNAS paper and our preprint.
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