Unbiasing in the Genome Analysis of Iconic Shark Species

Kazuaki Yamaguchi; Shigehiro Kuraku

doi:10.20944/preprints201911.0214.v1

Preprint Brief Report Version 1 This version is not peer-reviewed

Version 1 : Received: 11 November 2019 / Approved: 18 November 2019 / Online: 18 November 2019 (07:46:50 CET)

A previous study involving whole genome sequencing of the white shark suggested unique molecular evolution accounting for gigantism and the enhanced longevity of sharks including positive selection of dozens of protein-coding genes potentially involved in genome stability. We performed a reanalysis on some of the genes and identified serious flaws in their results. In this short article, we scrutinize one of the serious problems we identified, report other concerns, and point out a potential bias in analyzing iconic shark species in general.

https://www.nature.com/articles/s41559-018-0673-5: The authors' publication covering non-iconic shark species

shark; genome; longevity; gigantism; positive selection

Comment 1

Received: 18 November 2019
Commenter: Shigehiro Kuraku
The commenter has declared there is no conflict of interests.

Comment: I welcome any opinions and comments on the original PNAS paper and our preprint.

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Unbiasing in the Genome Analysis of Iconic Shark Species

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