Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Oxygen Desaturation Measured by Optical Sensor at Fingertip but Not at the Arm Is Diminished by Continuous Positive Airway Pressure in Obstructive Sleep Apnea

Version 1 : Received: 28 October 2021 / Approved: 2 November 2021 / Online: 2 November 2021 (10:52:45 CET)

A peer-reviewed article of this Preprint also exists.

Zhang, Z.; Qi, M.; Hügli, G.; Khatami, R. Quantitative Changes in Muscular and Capillary Oxygen Desaturation Measured by Optical Sensors during Continuous Positive Airway Pressure Titration for Obstructive Sleep Apnea. Biosensors 2022, 12, 3. Zhang, Z.; Qi, M.; Hügli, G.; Khatami, R. Quantitative Changes in Muscular and Capillary Oxygen Desaturation Measured by Optical Sensors during Continuous Positive Airway Pressure Titration for Obstructive Sleep Apnea. Biosensors 2022, 12, 3.

Journal reference: Biosensors 2021, 12, 3
DOI: 10.3390/bios12010003

Abstract

Obstructive sleep apnea (OSA) is a common sleep disorder, and continuous positive airways pressure (CPAP) is the most effective treatment. Poor adherence is one of the major challenges in CPAP therapy. The recent boom of wearable optical sensors measuring oxygen saturation makes the at-home multiple-night CPAP titrations possible, which may essentially improve the adherence of CPAP therapy by optimizing its pressure in a real-life setting economically. We tested whether the oxygen desaturations (OD) measured in the arm muscle (arm_OD) by gold-standard frequency-domain multi-distance near-infrared spectroscopy (FDMD-NIRS) changes with titrated CPAP pressures in OSA patients together with polysomnography. We found that the arm_OD (2.08 ± 1.23%, mean ± standard deviation) was significantly smaller (P-value <0.0001) than the fingertip OD (finger_OD) (4.46 ± 2.37%) measured by polysomnography pulse oximeter. Linear mixed-effects models suggested that CPAP pressure was a significant predictor for finger_OD but not for arm_OD. Since FDMD-NIRS measures a mixture of arterial and venous OD, whereas fingertip pulse oximeter measures arterial OD, our results of no association between arm_OD and finger_OD indicate that the arm_OD mainly represented venous desaturation. Arm_OD measured by near-infrared optical sensors may be not a suitable indicator of the effectiveness of CPAP titration.

Keywords

Obstructive sleep apnea; Continuous positive airways pressure therapy; Near-infrared spectroscopy; Oxygen desaturation; Arm; Pulse oximeter

Subject

ENGINEERING, Biomedical & Chemical Engineering

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