To enable net zero sustainable thermal building energy this study develops an open-source thermal house model to couple solar photovoltaic (PV) and heat pumps (HP) for grid-connected residential housing. The calculation of both space heating and cooling thermal loads and the selection of HP is accomplished with a validated Python model for air-source heat pumps. The capacity of PV required to supply the HPs is calculated using an System Advisor Model integrated Python model. Self-sufficiency and self-consumption of PV and the energy imported/exported to the grid for a case study are provided, which shows that simulations based on the monthly load profile have a significant reduction of 43% for energy sent to/from the grid compared to the detailed hourly simulation and an increase from 30% to 60% for self-consumption and self-sufficiency. These results show the importance of more granular modeling and also indicate mismatches of PV generation and HP load based on hourly simulation datasets. The back-calculation PV sizing algorithm combined with HP and thermal loads presented in this study exhibited robust performance. The results indicate this approach can be used to accelerate the solar electrification of heating and cooling to offset the use of fossil fuels in northern climates.

The growing urgency for sustainable energy solutions necessitates a deeper understanding of the environmental impacts of renewable technologies. This article aims to synthesize and analyze Life Cycle Assessments (LCA) in this domain, providing a comprehensive perspective. We systematically categorize 2,923 articles into four communities: (1) Photovoltaic systems, (2) Wind energy systems, (3) Materials for auxiliary industry of photovoltaic and wind systems, and (4) Solar thermal systems. A comparative analysis is conducted to identify methodological consistencies and disparities across these communities. The findings reveal diverse methodological approaches and a range of environmental impacts, highlighting the complexities in assessing renewable energy systems. The article underscores the significance of material selection in photovoltaic and wind systems, providing a critical overview of the current state of LCA research in renewable energy and stressing the need for standardized methodologies. It also identifies gaps in recent research, offering insights for future studies focused on integrating environmental, economic, and social considerations in renewable energy assessments.As a case study, an LCA was used to evaluate two energy supply methods for a sensor network: one connected to the public grid and another powered by a photovoltaic panel. The off-grid system, while more environmentally friendly by reducing reliance on non-renewable energy sources, posed challenges due to the high environmental impact of battery production and disposal. Integrating environmental assessments provides a robust framework for making informed decisions on sustainable technologies. The findings are critical for projects that balance technological needs with sustainability goals.

A joint analysis of solar wind, geomagnetic field, and earthquake catalog data showed that before the catastrophic M7.8 and M7.5 Kahramanmaras earthquake sequence on February 6, 2023, the closed strong magnetic storm occurred on November 7, 2022, SYM/H=-117 nT. Storm started at 08:04 UT. At this time, the high latitudinal part of Turkey's longitudinal region of future epicenters was located under the polar cusp, where the solar wind plasma would directly access the Earth's environment. The time delay between storm onset and earthquake occurrence was ~91 days. We analyzed all seven strong (M7+) earthquakes from 1967 to 2020 to verify the initial findings. A similar pattern has been revealed for all events. The time delay between magnetic storm onset and earthquake occurrence varies from some days to some months. To continue these investigations, a retrospective analysis of seismic and other geophysical parameters just after preceded geomagnetic storms in the epicenter areas is desirable.

Earthquake-triggered landslides are one of the most significant hazards worldwide. These landslides, involving small or large volumes, can develop in debris flow or avalanche with high mobility and long-runout distance. The motion processes of this kind of landslide also quite complicated. This study reproduced the motion processes of two landslides using the LS-RAPID program. The Aso Bridge landslide occurred on April 16, 2016, with rapid and long-runout distance characteristics. The Kataragai landslide occurred on April 9, 2018, travelling with flow-like behavior. Through field investigations and laboratory experiments, features and mechanical parameters of these two landslides were obtained. In the LS-RAPID program, the pre-failure models and motion processes of these two landslides were established and reproduced. Results indicated that sliding speed and travelling morphology at different intervals were considered as two indicators to describe their motion process. However, while sliding speed of these two landslides have significant differences with sliding speeds of actual landslides, the final morphologies after failure were consistent with those observed in the field investigation.

Natural killer (NK) cells play a crucial role in innate immunity, particularly in combating infections and tumors. However, in hematological cancers, NK cells often exhibit impaired functions. Therefore, it is very important to activate its endosomal toll-like receptors (TLRs) as a potential strategy to restore its antitumor activity. We stimulate NK cells from the peripheral blood mononuclear cells from children with acute lymphoblastic leukemia and NK cells isolated, the NK cells were stimulated with specific TLR ligands (Poly I:C, Imiquimod, R848, and ODN2006) and evaluated changes in IFN-γ, CD107a, NKG2D, NKp44 expression, Granzyme B secretion, cytokine/chemokine release, and cytotoxic activity. Results revealed that Poly I:C and Imiquimod enhanced activation of both immunoregulatory and cytotoxic NK cells, increasing IFN-γ, CD107a, NKG2D, and NKp44 expression. R848 activated immunoregulatory NK cells, while ODN2006 boosted CD107a, NKp44, NKG2D, and IFN-γ secretion in cytotoxic NK cells. R848 also increased secretion of various cytokines/chemokines. Importantly, R848 and ODN 2006 significantly improved cytotoxicity against leukemic cells. Overall, TLR stimulation enhances NK cell activation, suggesting TLR8 (R848) and TLR9 (ODN 2006) ligands as promising candidates for antitumor immunotherapy.

Novel far-red-sensitive symmetric squaraine (SQ) dyes with terminal alkyl-chain modifications were designed, synthesized and characterized aiming towards imparting multifunctionalities such as photosensitization, dye aggregation prevention and source of electrolyte components. The dye sensitizers SQ-77 and SQ-80 with the alkyl chain terminal modifications consisting of iodine and 1-methylimidazolium iodide, respectively, were designed and synthesized as new dye sensitizers for DSSCs based on the symmetric SQ-5 without any terminal modification used as reference. Upon adsorption on the mesoporous TiO2 surface, The SQ-77 depicted an enhanced dye loading and dye aggregation. On the other hand, SQ-80 demonstrated reduced dye aggregation and stronger binding on the TiO2 surface leading to enhanced durability of DSSCs. Apart from the most common photosensitization behaviour, the newly designed dye demonstrated multifunctionality such as aggregation prevention and electrolyte functionality utilizing iodine-based redox electrolyte in the presence and absence of I2 and LiI additives. In the absence of LiI and I2, a mixture of SQ-77 and SQ-80 demonstrated a photoconversion efficiency of 1.54 % under simulated solar irradiation, which was about 6 times higher as compared to reference dye SQ-5 (0.24 %) having no alkyl chai terminal modification.

This article reports the results of an ecological study of cancer incidence rates by state in the US for the period 2016-2020. The goals of this study were to determine the extent to which solar UVB doses still reduced cancer risk compared to findings reported in 2006 for cancer mortality rates for the periods 1950–1969 and 1970-1794 as well as cancer incidence rates for the period 1998–2002 and to determine which factors were recently associated with cancer risk. The cancer data were obtained from the Centers for Disease Control and Prevention. Indices were obtained for solar UVB at the surface for July 1992, and alcohol consumption, and diabetes and obesity prevalence near the 2016–2020 period. Lung cancer incidence rates were also used in the analyses. The cancers for which solar UVB is significantly associated with reduced incidence are bladder, brain (males), breast, corpus uteri, esophageal, gastric, non-Hodgkin’s lymphoma, pancreatic, and renal cancer. Lung cancer was significantly associated with colorectal, laryngeal, and renal cancer. Diabetes was also significantly associated with breast, liver, and lung cancer. Obesity prevalence was significantly associated with breast, colorectal and renal cancer. Alcohol consumption was associated with bladder and esophageal cancer. Thus diet has become a very important driver of cancer incidence rates. The dietary approach that would reduce the risk of diabetes, obesity, lung cancer, and, therefore cancer, would be one based mostly on whole-plants and restrictions on red and processed meats and ultraprocessed foods.

Buildings’ thermal energy needs are inherently linked to climate conditions. Consequently, it is crucial to evaluate how climate changes affect these energy demands. Despite extensive analysis, a comprehensive assessment involving a diverse range of building types has not been consistently conducted. The primary objective of this research is to perform a coherent evaluation of the influence of climate changes, construction element properties, and the Heating, Ventilation, and Air Conditioning (HVAC) system type of control on the energy requirements of six buildings (residential, services, and commercial). The buildings are considered located in a temperate Mediterranean climate. Our focus is on the year 2070, considering three distinct climatic scenarios: (i) maintaining the current climate without further changes, (ii) moderate climate changes, and (iii) extreme climate changes. The buildings are distributed across three different locations, each characterized by unique climatic conditions. Buildings’ envelope features a traditional External Thermal Insulation Composite System (ETICS) and expanded polystyrene (EPS) serves as thermal insulation material. Two critical design factors are explored: EPS thickness ranging from 0 (no insulation) to 12 cm; and horizontal external fixed shading elements varying lengths from 0 (absence) to 150 cm. Six alternative setpoint ranges are assessed for the HVAC system control: three based on the Predicted Mean Vote (PMV) and three based on indoor air temperature (Tair). Results were obtained with a validated in-home software tool. They show that, even under extreme climate conditions, the application of thermal insulation remains energetically favorable, however its relative importance diminishes as climate severity increases. Then, proper insulation design remains important for energy efficiency. The use of external shading elements for glazing (e.g., overhangs, louvers) proves beneficial in specific cases. As climate changes intensify, the significance of shading elements grows. Thus, strategic placement and design are necessary for good results. The HVAC system’s energy consumption depends on the level of thermal comfort requirements, on the climate characteristics and on the building’s type of use. As climate change severity intensifies, energy demands for cooling increase, while energy needs for heating decrease. However, it’s essential to recognize that the impact of climate changes on HVAC system energy consumption significantly depends on the type of building.

The literature shows that both in laboratory and in industrial conditions, photocatalytic oxidation method copes quite well with the degradation of the most organic substances, including environmental toxins and molecular components of pathogenic microorganisms. However, the effective utilization of photocatalytic processes for environmental decontamination and disinfection require significant technological advancement both in the area of semiconductor material synthesis and its application. Here we focused on the presence and ‘photocatalytic capability‘ of photocatalysts among soil minerals, and their potential contribution to the environmental decontamination in vitro and in vivo. (The issue is sketched from the perspective of chemists and environmental scientist.) Reactions caused by sunlight on the soil surface are involved in its normal redox activity. It appears that some of them may take part in the soil decontamination. However, their importance for decontamination in vivo cannot be overstated due to diversity of soils on the Earth caused by the environmental conditions, such as climate, parent material, relief, vegetation etc. The solar-light induced reactions are just a part of extremely complicated processes dependent on a plethora of environmental determinates. Such multiplicity of affecting factors, which we tried to sketch from the perspective of chemists and environmental scientist, makes us rather sceptical about the effectiveness of the photocatalytic processes in vivo. On the other hand, there is a huge potential of the soils as the alternative source of useful photocatalytic materials of unique properties

Solar energetic particles (SEPs) are bursts of high-energy particles that originate from the Sun and can last for hours or even days. The aim of this study is to understand how the characteristics of energetic particles was affected by the characteristic parameters of corotating interaction regions (CIRs). In particular, the particle intensity distribution with time and space in different CIRs are studied. The propagation and acceleration of particles are described by the focused transport equation (FTE). We used a three-dimensional magnetohydrodynamic (MHD) model to simulate the background field including CIRs. By changing the inner boundary conditions, we constructed CIRs with different solar wind speeds, angles between the polar axis and rotation axis, and the azimuthal widths of the fast streams. Impulsive particles are injected at the inner boundary. We then study the SEPs in different backgrounds. The results show that the CIR widths are related to the solar wind speed, tilt angles, and the azimuthal widths of the fast stream. The acceleration of particles in the reverse and forward compression regions is mainly influenced by the solar wind speed difference and the slow solar wind speed, respectively. Particles with lower energy (sub-MeV) are more sensitive to the parameters of CIRs. Different CIR parameters also greatly affect the spatio-temporal distribution of particle intensities in different ways. These results indicate that, it is crucial to consider the conditions of large-scale structure in interplanetary space when studying or predicting energetic particles. Additionally, our findings provide empirical guidance for forecasting the characteristics of SEPs.

Introduction: Signet-ring cells are typically associated with mucin-secreting epithelium thus most commonly found in a gastrointestinal tract, however not exclusively. Primary signet ring cell carcinoma of the prostate is a rare and poorly differentiated, aggressive acinar adenocarcinoma variant with a grim prognosis. Clinical case: In June of 2023 a 54-year-old Caucasian male came to the hospital complaining of lower urinary tract obstructive symptoms with occasional macrohematuria, non-specific body aches, and shortness of breath. A prostate specimen obtained in transurethral resection of the prostate was sent for histopathological examination. After a series of extraprostatic diagnostic workups including fibrogastroduodenoscopy, colonoscopy computed tomography imaging, and immunohistochemical studies, the patient was diagnosed with primary prostatic signet-ring cell adenocarcinoma st. IV. Unfortunately, the patient with the disease this advanced, PE, and third-degree thrombocytopenia was not a candidate for chemotherapy and died of cardiopulmonary insufficiency later that week. Discussion: Prostatic signet-ring cell carcinoma accounts for 0.02% of all prostate adenocarcinoma cases. Due to its nature and epidemiology, a diligent extraprostatic investigation has to be carried out. The disease often presents with unremarkable clinical symptoms and variable serum prostate-specific antigen results which may contribute to its late diagnosis which together with inconsistent immunohistochemical findings and unpredictable response to hormonal treatment pose both diagnostic and therapeutic challenges that negatively affect the prognosis. Conclusion: The study highlights the importance of a multidisciplinary approach and the need for diagnostic and therapeutic consensus within the research community in search of the primary site of the disease which may positively influence the prognosis.

Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to most explored nanoparticles because of the absence of viral genetic material, their incapacity to replicate, mimicry of viral structure, and tropism conservation. Furthermore, VLPs can be surface functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. In this review, we address the different types of functionalization of VLPs, their importance, and their consequent biomedical applications.

Membrane gas absorption technology and solar-assisted regeneration system are two promising approaches to reduce high energy consumption associated with carbon dioxide capture from coal fired power plants. In the present study, a solar-assisted hollow fiber membrane contactor (SOL-HFMC) power plant is proposed to capture and desorb CO₂ in hollow fiber membrane contactors with the assistance of solar thermal collectors. Techno-economic assessment and sensitivity analysis of the proposed system is carried out in three studied locations with different weather conditions for a 580 MWe pulverized coal power plant. Research results show that, the output capacity and net efficiency of the SOL-HFMC power plant are significantly higher than those of the reference power plant regardless whether TES system is applied or not. In addition, CEI of the SOL-HFMC power plant with TES system is 4.36 kg CO₂/MWh, 4.45 kg CO₂/MWh and 4.66 kg CO₂/MWh lower than that of the reference power plant. The prices of membrane, vacuum tube collector and phase change material should be reduced to achieve lower LCOE and COR values. Specifically for SOL-HFMC power plant with TES system, the corresponding vacuum tube collector price shall be lower than 25.70 $/m² for Jinan, 95.20 $/m² for Xining, and 128.70 $/m² for Lhasa, respectively. To be more competitive than solar-assisted ammonia-based post-combustion CO₂ capture power plant, the membrane price in Jinan, Xining and Lhasa shall be reduced to 0.012 $/m, 0.015 $/m and 0.016 $/m for the sake of LCOE, and 0.03 $/m, 0.033 $/m and 0.034 $/m for the sake of COR, respectively. The findings can provide guidance for decision-making and risk management strategies.

Respiratory syncytial virus (RSV) infection is a major cause of severe respiratory disease in infants and young children worldwide. Two vaccines targeting the elderly and pregnant women have been recently approved employing the prefusion form of the RSV-fusion protein (F). However, there are currently no vaccines for infants. Studies have shown a fusion-inactive prefusogenic F form is significantly more immunogenic and produces higher antibody titers to both the prefusion and postfusion structures of the F protein. Here we have developed RSV virus-like particles (RSV-VLPs) consisting of prefusogenic F, RSV glycoprotein and matrix proteins, produced them using the baculovirus expression system, and studied their protective efficacy in Balb/c mice. Morphology and successful assembly of VLPs were confirmed by transmission electron microscopy and western blot. Mice immunized with VLPs developed high levels of serum IgG and neutralizing antibodies as compared with mice immunized with inactivated virus. The VLP vaccine also induced higher levels of IFNγ and IL4, elicited limited proliferation of CD4+ and CD8+ T cells but higher cytotoxic-T-lymphocyte responses. VLP immunization abolished lung pathology in the mice after RSV challenge. Overall, our results indicate that RSV-VLPs consisting of prefusogenic F, glycoprotein and matrix proteins are a potential vaccine candidate against RSV.

This paper examines the response of the ionosphere to the impact of two moderate geomagnetic storms observed in January 17 and 26-27, 2013 under conditions of strong sudden stratospheric warming. The study uses data from ground-based ionosonde measurements at the Alma-Ata ionospheric station (43.25 N, 76.92 E) combined with optical observation data (The Spectral Airglow Temperature Imager (SATI)). Ionosonde data showed that the geomagnetic storms under consideration do not generate ionospheric storms, but demonstrate some unusual types of diurnal foF2 variations with large (up to 60%) deviations of foF2 from median values observed during the night/morning periods on 13-15 and 20-23 January which do not have any relation to solar or geomagnetic activity. Wave-like disturbances in foF2, h’F and daily averaged foF2 values with quasi-period of 5-8 days and peak-to-peak amplitude from about 1MHz to 2 MHz (from 20% to 40%) and ~40 km are observed during the 9-28 January, after registration the occurrence of the major SSW event on 6-7 January. The observed variations in the OH emission rate are found to be quite similar to those observed in the ionosheric parameters that assume a community of processes in the stratosphere/mesosphere/ionosphere system. The study shows that the F-region of the ionosphere is influenced by processes in the lower ionosphere, in this case by processes associated with sudden stratospheric warming SSW-2013, which led to modification of the structure of the ionosphere and compensation of processes associated with the development of the ionospheric storms.

The pointing accuracy of large radio telescopes is affected by antenna structure errors, installation errors, servo errors, gravity, and varying environmental factors. It is hard to estimate the pointing error of radio telescopes under solar radiation via the traditional multi-parameter static pointing models, due to the time-varying characteristics of the dynamic pointing error. There is still no effective way to estimate the dynamic pointing error of large radio telescopes under solar radiation up to now. To estimate the dynamic pointing error of large radio telescopes under solar radiation, a new way based on digital twin(DT) is tried in this paper. The operational framework of the DT system of large radio telescopes is introduced first. Then, the Wuqing 70-m radio telescope(WRT70) is taken as the research object, the digital models of which are created. Finally, the reliability of the WRT70's DT system is verified and the dynamic pointing error of WRT70(staying at the position of the elevation angle of 90° and the azimuth angle of 180°) on two sunny days in different seasons is estimated by the created DT system. The research results show that the pointing error of large radio telescopes under solar radiation fluctuates greatly and the seasonal differences are very striking. The maximum elevation pointing error of WRT70 under solar radiation around the winter solstice is over 40 arcsec, which should never be ignored. The way is feasible to estimate the dynamic pointing error of large radio telescopes staying at a specific position under solar radiation via constructing a DT system in this paper, but it is not yet able to estimate effectively the dynamic pointing error of large radio telescopes being in action. It is expected to establish a dynamic pointing error model and calibrate the dynamic pointing errors of large radio telescopes being in action by DT technology in the future.

The spectra and global distributions of the X-ray emissions generated by the solar wind charge-exchange (SWCX) process in the terrestrial magnetosheath are investigated based on a global hybrid model and a global geocoronal hydrogen model. The solar wind O6+ ions which are the primary charge state for oxygen ions in solar wind are considered. The line emissivity of the charge-exchange born O5+ ions are calculated by Spectral Analysis System for Astrophysical and Lab oratory (SASAL). It is found that the emission lines from the O5+ ranges from 105.607 to 118.291 eV with the strong line at 107.047 eV. We then simulated the magnetosheath X-ray emission intensity distributions with a virtual camera at two positions of north pole and dusk at six stages during the passing of a perpendicular interplanetary shock combined with a tangential discontinuity structure through the Earth’s magnetosphere. During this process, the X-ray emission intensity increases with time, and the maximum value is 27.11 keV cm-2 s-1 sr-1 on the dayside, which is 4.5 times that before the solar wind structure reaches the Earth. A clear shock structure can be seen in the magnetosheath and moves earthward. The maximum emission intensity seen at dusk is always higher than that seen at north pole.

This paper investigates an innovative photovoltaic cell configuration, denoted as “Au/CuSCN/RbGeI3/CdTe/ZnO/TiO2/FTO", using SCAPS-1D simulation. The research focuses on optimizing device performance by analyzing key components, including ZnO as the electron transport layer (ETL), RbGeI3 as the perovskite absorber layer, CuSCN as the hole transport layer (HTL), and CdTe as the active buffer layer. A comparison is made with the standard “Au/CuSCN/CH3NH3SnI3/CdTe/ZnO/TiO2/FTO" configuration under dark and illuminated conditions. Through an in-depth investigation involving temperature effects, generation rate analysis, RbGeI3 absorber layer thickness, Nd level, and interface defect levels, an optimized design for a unit area is achieved. The proposed solar cell demonstrates outstanding performance metrics, including an open circuit voltage (Voc) of 0.94V, a short circuit current density (Jsc) of 34.52mA/cm2, a fill factor (FF) of 77.77%, and an energy conversion efficiency (η) of 25.40%. These values significantly outperform the reference models with energy conversion efficiencies of 10.11% and 21.09%. Real-world applicability is validated by implementing these optimized characteristics in a photovoltaic system for Pakistan’s geographical location using PVSyst software. The suggested solar cell achieves a remarkable performance ratio (PR) of 85.6%, surpassing the PR of the reference basic solar cell model at 83%. The findings of this research offer a promising and superior solar cell design, incorporating innovative materials and optimization techniques to achieve exceptional energy conversion efficiency and overall performance. This study’s outcomes have the potential to advance photovoltaic technology and contribute to sustainable energy solutions worldwide.

Organic solar cells are contributing extensively to the production of future large area and cost-effective sources of renewable energy with a compact environmental impact. Moreover, due to tunable optical properties of the active medium, the semi-transparent organic solar cell can be fabricated and become a promising nominee for building Integrated Photovoltaics (BIPV), vehicles, and mobile electronic devices. Therefore, three newly synthesized polymers used as were host materials for the active medium and blended with beetroot dye. Hence, based on BHJ structure two ternary systems have been constructed and utilized to fabricate semitransparent solar cells and characterized. The results show that the natural dye has a crucial impact on solar cell characteristic parameters. Consequently, large value of V_OC close to 1V were obtained for ternary systems and acceptor material named PINDOLE exhibits potentials for electron transport layer (ETL) and shows an improvement in both fill factor and device efficiency.

Hyperplastic nodules (HNs) are benign polypoid lesions of the colorectal mucosa reportedly caused by hyperplasia of the crypt epithelial cells. They differ from hyperplastic polyps because the crypts do not have histologically serrated changes. HNs often occur in the rectal mucosa and tend to be multifocal. We have proposed a new colitis nucleomigrans (CN) concept as the third type of microscopic colitis. Our histopathological criteria of CN include: i) chained nuclear migration to the middle part of the surface-lining columnar epithelium, ii) apoptotic nuclear debris scattered in the eosinophilic cytoplasm underneath the nuclei, and iii) mild to moderate chronic inflammation in the lamina propria. Immunostaining for cleaved-caspase 3 revealed apoptotic bodies. In this study, we report that most HN lesions share the histological features with CN, representing polypoid CN. We evaluated 108 lesions of HN in total, and 94 (87%) were reclassified as polypoid CN. In the polypoid CN, the lamina propria mucosae were uniformly edematous, suggesting that accelerated apoptosis of the mucosal surface epithelium may cause osmotic dysregulation to form localized mucosal elevations.

Presently, Jordan confronts a double substantial challenge of enhancing energy security and mitigating greenhouse gas emissions. One of the most encouraging avenues to attain the objectives of sustainable development, energy security, and environmental conservation is to enhance the integration of renewable energy into the generation of electricity. In pursuit of this goal, the Jordanian government intends to expand investments in the green energy sector, with solar and wind energy poised to play a key role in satisfying energy demands and cultivating an environmental sustainability. This paper aims to examine the distinctive dynamics, challenges, obstacles, and potential solutions corresponding to the establishment of community solar and wind farms in Jordan suburban areas. It aims to highlight the opportunities and barriers influencing the track of sustainable energy adoption in the country. Through a comprehensive analysis of the Jordanian context, the goal is to extract insights that can guide policies and practices. Additionally, the findings may serve as a valuable benchmark for other regions confronting similar challenges on their pursuit for a sustainable energy future.

During choriogenesis in insects, chorion (eggshell) is formed by surrounding follicular epithelial cells in ovarioles. However, the regulatory endocrine factor(s) activating choriogenesis and the chemical components on eggshell deserve further exploration. In two representative Coleopterans, a Coccinellid Henosepilachna vigintioctopunctata and a Chrysomelid Leptinotarsa decemlineata, genes encoding the 20-hydroxyecdysone (20E) receptor heterodimer, ecdysone receptor (EcR) and ultraspiracle (USP), and two chitin biosynthesis enzymes UDP-N-acetylglucosamine pyrophosphorylase (UAP) and chitin synthase (ChS1), were highly expressed in ovaries of the young females. RNA interference (RNAi)-aided knockdown of either HvEcR or Hvusp in H. vigintioctopunctata inhibited oviposition, suppressed the expression of HvChS1, and lessened the positive signal of Calcofluor staining on the chorions, which suggests the reduction of a chitin-like substance (CLS) deposited on eggshells. Similarly, RNAi of LdEcR or Ldusp in L. decemlineata constrained oviposition, decreased the expression of LdUAP1 and LdChS1, and declined CLS contents in the resultant ovaries. Knockdown of LdUAP1 or LdChS1 caused similar defective phenotypes, i.e., reduced oviposition and CLS contents in the L. decemlineata ovaries. These results, for the first time, indicate that 20E signaling activates choriogenesis in two Coleopteran species. Moreover, our findings propose the deposition of a CLS on the chorions.

Abstract: Kiwifruit, a perennial horticultural crop known for its nutritional value, faces significant challenges due to biotic and abiotic stresses, affecting its yield and quality. Leucine-rich repeat receptor-like proteins (LRR-RLPs), a major group of receptor-like proteins in plants, have diverse functions in plant physiology, including growth, development, signal transduction, and stress responses. Despite their importance, the specific roles of kiwifruit LRR-RLPs in response to biotic and abiotic stresses remain poorly understood. In this study, we investigated the expression patterns of kiwifruit LRR-RLPs under various stress conditions, including pathogen stress, heat stress, waterlogging stress, and copper stress. Through genome and transcriptome analyses, we identified a total of 101, 164, and 105 LRR-RLPs in Actinidia Chinensis 'Hongyang', Actinidia eriantha 'Huate', and Actinidia chinensis 'Red5' kiwifruit, respectively, classified into 9 subgroups based on phylogenetic relationships. Synteny analysis revealed that the expansion of kiwifruit LRR-RLPs was primarily attributed to segmental duplication events. Using RNA-seq data from pathogen-infected kiwifruits, we identified specific LRR-RLP genes potentially involved in different stages of pathogen infection. Additionally, we observed the potential involvement of kiwifruit LRR-RLPs in abiotic stress responses, with upstream transcription factors possibly regulating their expression. Furthermore, protein interaction network analysis unveiled the participation of kiwifruit LRR-RLP genes in the regulatory network of abiotic stress responses. These findings highlight the crucial roles of LRR-RLPs in mediating both biotic and abiotic stress responses in kiwifruit, offering valuable insights for the breeding of stress-resistant kiwifruit varieties.

This paper provides a study on the development of solar energy, its prospects, and its impacts in Africa. Although the main focus is on technologies adopted for different uses (solar farms, mini-grids, off-grid, solar houses, irrigation, lighting, etc.), we also consider some aspects that increase the adoption of solar energy, such as legislation and business models. Finally, we will examine current and future solar projects managed by NGOs and international companies and how they benefit to leveraging social and economic standards, quality of life as well as capacity building in Africa. This study shows the plethoric interest of institutions outside Africa in the market of solar energy in the continent and that there is no African strategy to increase its independency toward a sustainable development particularly through energy transition.

The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs). This study centers on the intricate interplay between the CACCC-box and its binding proteins such as: the Krüppel-like family (KLF) of transcription factors as primary effectors in the context of CVDs. Our analysis was through a bioinformatics approach, which reveal significant transcriptional activity among KLF subgroup 2, exhibiting the highest number of interactions focusing on the established roles: pluripotency, cancer, and cardiovascular development and diseases. Our analysis reveals KLF's interactions with GATA4, MEF2C, NKX2.5 and other ~ 90 potential genes that participate in the regulation of the hypertrophic environment (or CVD's Environment). Also, the GO analysis showed genes containing the motif CACCC were enriched for multiple CVD’s, in combination with STRING analysis these results pointed to a link between KLFs and these diseases. The analysis further identifies other potential CACCC-box binding factors, such as SP family members, WT1, VEZF1, and -SALL4, which are implicated in cardiac contraction, remodeling, and inflammation processes.

We delve into nonrelativistic quantum electrodynamics within a background magnetic field, ensuring gauge invariance via a vector potential. Our exploration extends to the Lagrangian, which incorporates electron self-interactions and electromagnetic field interactions. Through the path integral formalism, we elucidate the effective action, with a specific focus on the photon propagator and screening effects. Examining density and current components reveals Laurent expansions in the hydrodynamic limit. The equations of motion in real space are derived, leading to discussions on phenomena such as Poiseuille-like flow and the Navier-Stokes equation. To ground our theoretical framework at practical contexts, we consider applications such as the fluid dynamics at binary star systems. Depending on the velocity of the expelled fluid, our analysis allows for both nonrelativistic and relativistic treatments, providing a versatile tool for understanding the intricacies of fluid behavior at astrophysical scenarios. Additionally, we recognize that at the presence of a magnetic field, magnetohydrodynamics becomes crucial. While our current focus is at nonrelativistic quantum electrodynamics, the insights gained here contribute to a broader understanding, offering a comprehensive foundation for quantum electrodynamics analysis at diverse physical systems.

The research develops and validates new decomposition models for DNI estimations from Southern African data. The results demonstrated improved DNI estimation accuracy compared to the baseline models across all testing and validation datasets. These outcomes suggest that utilising a localised model can significantly enhance DNI estimations for Southern Africa and potentially for developing similar models in diverse geographic regions worldwide. Furthermore, clustered models highlighted the potential advantages of grouping data based on shared geographical and climatic attributes. This clustering approach could enhance decomposition model performance, particularly when local data is limited or data is available from multiple nearby stations. The Southern African decomposition model, which encompasses a wide spectrum of climatic regions and geographic locations, exhibited notable improvements over the baseline models despite occasional overestimation or underestimation. The overall metrics affirm the substantial advancement achieved with the Southern African model. This study focused on validating the model for hourly DNI in Southern Africa within a range of clearness index-intervals from 0.175 to 0.875. Implementing accurate decomposition models in developing countries can accelerate the adoption of renewable energy sources, diminishing reliance on coal and fossil fuels.

Chlamydia trachomatis (Ct) infections are the most common sexually-transmitted infection (STI). Despite effective antibiotics for Ct, undetected infections or delayed treatment can lead to infertility, ectopic pregnancies, and chronic pelvic pain. Besides humans, chlamydia poses similar health challenges in animals such as C. suis (Cs) in pigs. Based on the similarities between humans and pigs as well as their chlamydia species, we use pigs as a large biomedical animal model for chlamydia research. In this study, we use the pig model to develop a vaccine candidate against Ct. The vaccine candidate consists of TriAdj-adjuvanted chlamydial protease-like activity factor (CPAF) protein. We tested two weekly administration options – twice intranasal (IN) followed by twice intramuscular (IM), or twice IM followed by twice IN. We assessed the humoral immune response not only in serum by CPAF-specific IgG including antibody avidity determination but also in cervical and rectal swabs by CPAF-specific IgG and IgA ELISAs. The systemic T-cell response was analyzed upon in vitro CPAF-restimulation via IFN-γ and IL-17 ELISpots as well as intracellular cytokine staining flow cytometry. Our data demonstrate that while the IN/IM vaccination mainly led to non-significant systemic immune responses, the vaccine candidate is highly immunogenic if administered IM/IN. This vaccination strategy induced high serum anti-CPAF IgG levels with strong avidity as well as high IgA and IgG levels in vaginal and rectal swabs and in uterine horn flushes. In addition, this vaccination strategy prompted a pronounced cellular immune response: Besides inducing IL-17 production, the vaccine candidate induced a strong IFN-γ response by CD4 T cells. In the IM/IN vaccinated pigs, these cells also significantly downregulated their CCR7 expression – a sign for differentiation into peripheral tissue homing effector/ memory cells. Conclusively, this study demonstrates strong immunogenicity of the IM/IN administered TriAdj-adjuvanted Ct CPAF vaccine candidate. Future studies will test vaccine efficacy of this promising Ct vaccine candidate. In addition, this project demonstrates suitability of the Cs pre-exposed outbred pig model for Ct vaccine development. Thereby, we aim to open the bottleneck of large animal models to facilitate the progression of Ct vaccine candidates into clinical trials.

Solar flares are characterized by sudden bursts of electromagnetic radiation from the Sun’s surface, and caused by the changes in magnetic field states in solar active regions. Earth and its surrounding space environment can suffer from various negative impacts caused by solar flares ranging from electronic communication disruption to radiation exposure-based health risks to the astronauts. In this paper, we address the solar flare prediction problem from magnetic field parameter-based multivariate time series (MVTS) data using multiple state-of-the-art machine learning classifiers that include MINImally RandOm Convolutional KErnel Transform (MINIROCKET), Support Vector Machine (SVM), Canonical Interval Forest (CIF), Multiple Representations SEQuence Learner (Mr-SEQL), and Long Short-Term Memory (LSTM)-based deep learning model. Our experiment is conducted on the on the Space Weather ANalytics for Solar Flares (SWAN-SF) benchmark data set, which is a partitioned collection of MVTS data of active region magnetic field parameters spanning over 9 years of operation of the Solar Dynamics Observatory (SDO). The MVTS instances of the SWAN-SF dataset are labeled by GOES X-ray flux-based flare class labels, and attributed to extreme class imbalance because of the rarity of the major flaring events (e.g., X and M). As a performance validation metric in this class-imbalanced dataset, we used the true skill statistic (TSS) score. Finally, we demonstrate the advantages of the MVTS learning algorithm MINIROCKET, which outperformed the aforementioned classifiers without the need for essential data preprocessing steps such as normalization, statistical summarization, and class imbalance handling heuristics.

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address the neuronal loss and the progression of the disease. It has been well established that neuronal nicotinic cholinergic receptors (nAChRs) can regulate DA release and that nicotine itself may have neuroprotective effects. Recent studies have identified nAChRs in nonneuronal cell types including glial cells, where they may regulate inflammatory responses. Given the crucial role of neuroinflammation in dopaminergic degeneration, and the involvement of microglia and astrocytes in this response, glial nAChRs may provide a novel therapeutic target in prevention and/or treatment of PD. In this review, following a brief discussion of PD, we focus on the role of glial cells and specifically their nAChRs in PD pathology and/or treatment.

The result of the multidisciplinary collaboration of researchers from different areas of knowledge to validate a solar radiation model is presented. The MAPsol is a 3D local-scale adaptive solar radiation model that allows to estimate direct, diffuse and reflected irradiance for clear sky conditions. The model includes the adaptation of the mesh to complex orography and albedo, and considers the shadows cast by the terrain and buildings. The surface mesh generation is based on surface refinement, smoothing and parameterisation techniques and allows the generation of high quality adapted meshes with a reasonable number of elements. Another key aspect of the paper is the generation of a high-resolution digital elevation model (DEM). This high-resolution DEM is constructed from LiDAR data and its resolution if two times more accurate than the publicly available DEMs. The validation process uses direct and global solar irradiance data obtained from pyranometers at the University of Salamanca located in an urban area affected by systematic shading from nearby buildings. This work provides an efficient protocol for studying solar resources, with particular emphasis on areas of complex orography and dense buildings where shadows can potentially make solar energy production facilities less efficient.

Abstract: The venom-containing barb attached to their ‘whip-like’ tail provides stingrays a defensive mechanism for evading predators such as sharks. From human encounters, dermal stingray envenomation is characterized by intense pain often followed by tissue necrosis occurring over several days to several weeks. The bioactive components in stingray venoms (SRV’s) and their molecular targets and mechanisms that mediate these complex responses are not well understood. Given the utility of venom-derived proteins from other venomous species for biomedical and pharmaceutical applications, we set out to characterize the bioactivity of SRV from three local species that belong to the Dasyatoidea ‘whiptail’ superfamily. Multiple cell-based assays were used to quantify and compare the in vitro effects of these SRV’s on different cell lines. All three SRV’s demonstrated concentration-dependent growth inhibitory effects on three different human cell lines tested. In contrast, a mouse fibrosarcoma cell line was markedly resistant to all three SRV’s, indicating the molecular target(s) for mediating the SRV effects are not expressed on these cells. The multifunctional SRV responses were characterized by an acute disruption of cell adhesion leading to apoptosis. These findings aim to guide future investigations of identified SRV proteins and their molecular targets for potential use in biomedical applications.

Chronic diseases, such as type 2 diabetes (T2D), are difficult to manage because they demand continuous therapeutic review and monitoring. Beyond achieving the target HbA1c, new guidelines for the therapy of T2D have been introduced with the new groups of antidiabetics (GLP-1ra and SGLT2-in). Despite new guidelines, clinical inertia, that can be caused by physicians, patients or healthcare system, results in T2D not being effectively managed. This opinion paper explores the shift in T2D treatment, challenging assumptions and evidence-based recommendations, particularly for family physicians, considering the patient's overall situation in decision-making. We looked for the possible reasons of clinical inertia and poor application of guidelines in the management of T2D. Guidelines for antidiabetic drugs should be more precise, providing case studies and clinical examples to define clinical contexts and contraindications. Knowledge communication can improve confidence and should include clear statements on areas of decision-making not supported by evidence. Precision medicine initiative in diabetes aims to identify subcategories of T2D patients (including frail patients) using clustering techniques from data science applications, focusing on CV and poor treatment outcomes. Clear, unconditional recommendations for personalized T2D management may encourage drug prescription, especially for family physicians dealing with diverse patient contexts and clinical settings.

The statistical analysis of impact of the top 50 solar flares of X-class (1997-2023) on the global seismic activity, as well as on the earthquake preparation zones located in illuminated part of the globe and in the area of 5000 km radius around the subsolar point was carried out. It is shown by a method of epoch superposition that for all cases the increase of seismicity is observed, especially in the region around the subsolar point (up to 38%) during 10 days after the solar flare in comparison with preceding 10 days. The case study of aftershock sequence of strong M=9.1 earthquake (Su-matra-Andaman Islands, 26.12.2004) after the solar flare of X7.2 class (20.01.2005) demonstrated that the number of aftershocks with magnitude M≥2.5 increases more than 20 times after the solar flare with a delay of 7 days. For the case of the Darfield earthquake (M=7.1, 04.09.2010, New Zealand) it was shown that strong solar flares of class X and M probably triggered two strong aftershocks (M>6) with the same delay of 6 days on the Port Hills fault, which is the most sensitive to external electromagnetic impact from point of view of the fault electrical conductivity and orientation. Based on the obtained results the possible application of natural electromagnetic triggering of earthquakes is discussed for a short-term earthquake prediction using confidently recorded strong external electromagnetic triggering impacts on the specific earthquake preparation zones, as well as ionospheric perturbations due to aerosol emission from the earthquake sources recorded by satellites.

Endoscopy has made a significant and noteworthy contribution to the field of medical science and technology. Nevertheless, its potential remains constrained due to the limited availability of rigid or flexible endoscopes. This paper introduces a novel hydraulic actuator based on electrorheological fluid (ERF) as a pivotal advancement in bridging the existing gap within the realm of endoscopy. Following a comprehensive introduction that briefly outlines the electrorheological effect, the subsequent section is dedicated to the elucidation of the actuator’s development process. Challenges arise, particularly in terms of miniaturization and the realization of a hydraulically sealed system with integrated valve electrodes. An internal electrorheological valve system consisting of four valves that are controlled using a pulse-width modulated high voltage was suitable for position control of the antagonistic hydraulic actuators. High-precision stereolithography (SLA) printing has proven practical for manufacturing the actuator components. For functional testing, a test bench was set up in which the actuator follows a setpoint through a PI control loop. The control deviation ranged from 0.6 to 1 degree, with a response time between 6 and 8 seconds. The experiments have demonstrated that, through the use of ERF and integrated valve electrodes, a miniaturized functional actuator can be constructed.

Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent world-wide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH). Fibrosis is often present during NAFLD progression; however, factors determining which subjects develop NASH or fibrosis are unclear. Insulin-like growth factor binding proteins (IGFBP) is a family of secreted proteins involved in senescence and scarring mainly synthetized in the liver. Here we aimed to study the association of IGFBP and its induced senescence with the progression of NAFLD and liver fibrosis. Materials and Methods: 16 weeks old male C57BL/6 mice weighing 23 ± 3 g were fed either Methionine-Choline Deficient or control diet for 2, 8 or 12 weeks. Blood and liver samples were collected; histological assessment of NAFLD and fibrosis was performed. Fat contents were measured. Cellular senescence was evaluated in the liver. IGFBP levels were assessed in liver and serum. Data was expressed as Mean ± SD and analyzed by one-way ANOVA followed Tukey’s test. Lineal regression models were applied for NAFLD and fibrosis progression. p

Photovoltaic materials convert light into electrical voltages. So far, most research in the field are focused on how to refine/improve the existing or standard photovoltaic cells to yield more efficient electricity, to reduce weight, to make more flexible shape, or to minimize costs under standard and uniform sunlight illuminations. In this project, we explore and demonstrate a hypothesis that non-uniform light illumination photovoltages can also be generated due to photo doping induced mobile charge carrier density gradient between light and dark areas in either p-type or n-type photo doping semiconductors. The term non-uniform light illumination was coined to refer to subjecting our photo sensing thin film devices to areas of high and low intensities of light illumination simultaneously, with an intention of creating a charge density gradient and therefore a voltage. Specifically, a polymeric composite thin film composed of P3HT (p-type photo doping semiconductor) and PCBM (photo doping electron acceptor and trap) at varying p-doping levels were studied. We observed that the fabricated photovoltaic cells with about 80% PCBM doped P3HT thin film devices exhibited 0.5-1.2 volts photovoltages under non-uniform light illuminations.

The quiet-time solar wind electrons feature non-thermal characteristics when viewed from the perspective of their velocity distribution functions. They typically have an appearance of being composed of a denser thermal “core” population plus a tenuous energetic “halo” population. At first, such a feature was empirically fitted with the Kappa velocity space distribution function, but ever since the ground-breaking work by Tsallis, the space physics community has embraced the potential implication of the Kappa distribution as reflecting the non-extensive nature of the space plasma. From the viewpoint of microscopic plasma theory, the formation of non-thermal electron velocity distribution function can be interpreted in terms of the plasma being in a state of turbulent quasi equilibrium. Such a finding brings forth the possible existence of a profound inter-relationship between the non-extensive statistical state and the turbulent quasi-equilibrium state. The present paper further develops the idea of solar wind electrons being in the turbulent equilibrium, but unlike the previous model, which involves the electrostatic turbulence near the plasma oscillation frequency (i.e., Langmuir turbulence), the present paper considers the impact of transverse electromagnetic turbulence, particularly, the turbulence in the whistler-mode frequency range. It is found that the coupling of spontaneously-emitted thermal fluctuations and the background turbulence leads to the formation of non-thermal electron velocity distribution function of the type observed in the solar wind during quiet times. This demonstrates that the whistler-range turbulence represents an alternative mechanism for producing the Kappa-like non-thermal distribution, especially close to the Sun and in the near-Earth space environment.

Redox mediators comprising I–, Co3+, and Ti3C2Tx MXene were applied to dye-sensitized solar cells (DSCs). In the as-prepared DSCs (I-DSCs), wherein hole conduction occurred via the redox reaction of I−/I3− ions, the power conversion efficiency (PCE) was not altered by the addition of Ti3C2Tx MXene. The I-DSCs were exposed to light to produce Co2+/Co3+-based cells (Co-DSCs), wherein the holes were transferred via the redox reaction of Co2+/Co3+ ions. A PCE of 9.01% was achieved in a Co-DSC with Ti3C2Tx MXene (Ti3C2Tx-Co-DSC), which indicated an improvement from the PCE of a bare Co-DSC without Ti3C2Tx MXene (7.27%). It was also found that the presence of Ti3C2Tx MXene in the redox mediator increased the hole collection, dye regeneration, and electron injection efficiencies of the Ti3C2Tx-Co-DSC, leading to an improvement in both the short-circuit current and the PCE when compared with those of the bare Co-DSC without MXene.

Solar photovoltaic (PV) generation suffers from multiple serious issues, for example shading effects directly affect the performance of installed PV arrays. By studying these issues, it can play a key role in improving the limitations and performance of PV panels. The study of PV arrays under partial shading conditions is mentioned in many papers as a part of other studies and as an independent phenomenon. Therefore, it is essential to improve these studies and update them with new research and study this problem in detail to know how to limit the effects of partial shading irradiance conditions on PV arrays performances, including economical aspects. This paper proposes to study the effects of different partial shading irradiance conditions for a PV array in various configurations. The analysis is proved in detail through the simulation of the proposed PV array in the Matlab/Simulink environment. The obtained results show the performances of interconnected PV arrays under different partial shading irradiance and temperature conditions, including the solar array I-V and P-V characteristics. In addition, different PV array configurations with and without bypass and blocking protection diodes improve and minimize the effect of partial shading conditions and avoid the reductions in output power.

We delve into the axion-dilaton model within the supergravity framework, with a specific focus on the intricacies of domain wall construction and stability. Employing holographic vitrification, we unravel the dynamics of domain wall formation in gauge theories featuring periodic vacuum structures. Our model, incorporating a QCD-like axion term and a stabilizing dilaton, undergoes scrutiny for conductivity variations under weak disorder. The investigation reveals the model's resilience, manifesting near-perfect conductivity under mild disorder conditions. However, the rigorous mathematical motivation for the holographic setup demands further elucidation. The scattered nature of our results prompts the necessity for a more systematic interpretation of QCD phenomena and conductivity transitions. This study contributes to the mathematical understanding of the axion-dilaton model's behavior, highlighting the imperative for a refined holographic framework and a more coherent interpretation of observed phenomena.

This paper offers a theoretical and experimental examination of the concurrent production of electricity and heat using photovoltaic thermal (PV/T) technology. The efficiency performance of the PV/T system is meticulously analyzed using MATLAB/Simulink software environments. Notably, the proposed PV/T system shows reliable performance, and its validity is confirmed through experimental validation on a test stand with a single PV/T panel positioned at a 45-degree angle to the horizontal and a 0-degree azimuth angle.

With the popularity of solar energy in the electricity market, demand arises for data such as precise locations of solar panels for efficient energy planning, management, and distribution. However, this data is not easily accessible and in some cases, information such as precise locations does not exist. Furthermore, existing data sets for training semantic segmentation models of PV installations are limited, and their annotation is time-consuming and labor-intensive. Therefore, for additional remote sensing (RS) data creation, the pix2pix generative adversarial network (GAN) is utilized, enriching the original resampled training data of varying GSDs without compromising its integrity. Experiments done with the DeepLabV3 model, ResNet-50 backbone, and pix2pix GAN architecture were conducted to find the optimal configuration for an accurate RS imagery segmentation model. The result is a fine-tuned solar panel semantic segmentation model, trained using transfer learning and utilizing an optimal amount – 60% of generated RS imagery for additional training data, increasing model accuracy. The findings demonstrate the benefits of using GAN-generated images as additional training data, increasing the size of small data sets, and improving the capabilities of the segmentation model for solar panel detection in RS images.

The origin of neurodegenerative diseases is linked to the abnormal folding of disease-associated proteins. The traditional amyloid hypothesis has been a focal point of research, but recent findings suggest a more complex picture. This review explores the role of physiological conformation of aggregation-prone domain (also known as prion-like low complexity domain) and multiple co-misfolded proteins in neurodegenerative diseases. We highlight the importance of targeting multi-heterotypic misfolded proteins for effective treatments and emphasize the irreversible neurodegeneration stemming from the loss of physiological folding in prion-like disease-causing proteins underscores the criticality of refolding. Additionally, we introduce the concept of ReproFold Therapeutics, a novel approach aimed at restoring the cellular prion-like folding of disease-causing proteins to rebuild normal cross-β interactomes and mitigate neurodegeneration. Baicalein, a potential drug candidate for this approach, shows promise in vitro and in animal models. Moreover, prion-like low complexity domains implicated in neurodegeneration are also associated with other disorders such as diabetes, cancers, and mental illnesses. Understanding the core pathology of neurodegenerative diseases and the broader implications of prion-like LC domains could revolutionize healthcare approaches and policies worldwide.

Many protein expression systems are primary utilised to produce a single, specific recombinant protein. In contrast, most biological processes such as virus assembly rely upon a complex of several interacting proteins rather than the activity of a sole protein. The high complexity of the baculovirus genome, coupled with a multiphase replication cycle incorporating distinct transcriptional steps, made it the ideal system to manipulate for high-level expression of a single or co-expression of multiple foreign proteins within a single cell. We have developed and utilised a series of recombinant baculovirus systems to unravel the sequential assembly process of a complex non-enveloped model virus, Bluetongue virus (BTV). The high protein yields expressed by the baculovirus system not only facilitated structure-function analysis of each viral proteins but were also advantageous to crystallography studies and supported the first atomic level resolution of a recombinant viral protein, the major BTV capsid protein. Further, the formation of recombinant double-shelled virus-like particles (VLPs) provided insights into the structure-function relationships among the four major structural proteins of the BTV whilst also representing a potential candidate for a viral vaccine. The baculovirus multi-gene expression system facilitated the study of structurally complex viruses (both non-enveloped and enveloped viruses) and heralded in a new generation of viral vaccines.

The per capita availability of freshwater resources on a global scale is gradually decreasing due to population growth, rapid urbanization, industrialization, and modern lifestyles. In this situation, wastewater management becomes a major concern. Conventional treatment processes used to treat wastewater discharges are not adequate for the advanced removal of pollutants, especially refractory organic pollutants, which are mainly organic compounds that are not easily biodegradable in the environment. The use of photocatalytic membrane reactors (PMRs) for tertiary wastewater treatment has attracted much interest in recent periods, and various configurations have been investigated. The performance of a PMR using an iron doped titanium photo catalyst and Polysulfone-based polymeric membrane for municipal wastewater treatment was evaluated under natural and simulated solar light. Obtained results proved that solar driven PMRs can remove organic loading (COD) with high efficiencies and may represent a suitable alternative for the tertiary treatment step of municipal wastewater.

Recent studies have elucidated the diversity of genes encoding venom in sea anemones. However, most of those genes are yet to be explored in an evolutionary context. Insulin is a common peptide across metazoans and has been coopted into a predatory venom in many venomous lineages. In this study, we focus on the diversity of insulin-derived venoms in sea anemones and on elucidating their evolutionary history. We sourced data for 34 species of sea anemones and found sequences belonging to two venom families that have Insulin PFAM annotations (Cono-Insulin, VP302). Our findings show that both families have undergone duplication events. Members of each of the independently evolving clades have consistent predicted protein structures and distinct dN/dS values. Our work also shows that VP302 is part of a multidomain venom contig and has experienced a secondary gain into the venom system of cuticulate sea anemones.

In this paper, the experimental results of the thermal sub-system of a reliable and cost-effective polygeneration solar system are presented. This polygeneration system produces heating, cooling and electricity from solar energy, which are used in an existing test-building. Heat is generated in four evacuated tube solar collectors (ETC). The heat may be used for space cooling, through a variable geometry ejector (VGE) heat pump. In order to reduce the mismatches between generation and consumption, two thermal storage tanks were added. The performance of a new thermal storage, with 400 l, able to storage both sensible and latent heat, was tested. Heating performances of the test-building were assessed. Ejector cycle tests were also performed.

Leukemia, contributing to 3% of all cancer cases in the United States, presents a significant challenge in treatment due to its diverse subtypes, each dis-playing unique genetic and molecular abnormalities. The aggressive growth of ab-normal blood cells compromises immune function and poses challenges in developing effective therapeutic approaches. Unlike solid tumors, surgical resection is not an option, limiting treatment strategies to chemotherapy, immunotherapy, and radiation therapy, which may be nonspecific and lead to organ damage and toxicity. Anthracyclines, widely used in hematological tumors, face limitations due to severe cardiotoxicity, causing progressive cardiomyopathy and, in severe cases, congestive heart failure. Heart failure incidence is significantly higher in cancer patients treated with anthracyclines over 5, 10, and 15 years. Early detection of left ventricular dysfunction and cardiotoxicity is crucial to mitigate progression to congestive heart failure (CHF) in this population. Recent research by Bayrón-Marrero et al. reveals that lower levels of plasma soluble TREM-Like Transcript-1 (s-TLT-1), a platelet-specific receptor, correlate with left ven-tricular dysfunction in cardiovascular disease patients. Those with s-TLT-1 levels ex-ceeding 544 pg/mL exhibit a significant association with congestive heart failure. These findings suggest the potential use of s-TLT-1 as a diagnostic screening tool for early detection and treatment of anthracycline-induced CHF in leukemia patients.

Technological advancements must keep pace with earth’s rising demand for energy, while minimizing the carbon footprint on earth. One such option is using space based solar (SBS) radio frequency (RF) microwave power beaming. This innovative and novel technology is currently being explored to address terrestrial photovoltaic (PV) intermittency and provide a method to transmit power to other spacecraft in various orbits. This modality of power generation and distribution presents a new way to power terrestrial off-grid applications and earth orbiting spacecraft. In 1968, Dr. Peter Glaser published "Power from the Sun: Its Future", which serves as the foundation of this paper to revitalize scientific interest and efforts in this topic. This paper will primarily focus on the reliance of SBS initiatives on reusable launch vehicles (RLV) to place SBS spacecraft in a designated orbit, as well as the technological, economic, and operational challenges associated with power beaming to earth and other spacecraft. This includes a discussion of the variables from the operational environment that contribute or accelerate spacecraft end of life.

As the cost of conventional energy continues to rise, and concerns over the environment grow, there is a growing interest in sustainable energy. It is believed that conventional energy will only last for around 50 years, making it essential to find a renewable energy source that is safe and feasible to replace fossil fuels. Solar energy is a superior alternative to conventional energy, as it is renewable and produces green energy that can be used directly. The maritime industry has found itself at the forefront of an evolving environmental consciousness, driven by the imperative to mitigate the carbon footprint left in the wake of ships. In this journey towards sustainability, solar energy has emerged as a beacon of hope, harnessing the boundless energy of the sun to wean vessels off their dependence on fossil fuels. Technological advancements have made solar power more accessible, and we can now see the use of solar panels on large ships and small crafts to reduce fuel usage and emissions. Solar panels are also increasingly used to power homes and businesses, and many countries are implementing policies to encourage their use. Solar energy is a key solution in reducing our dependence on non-renewable energy sources and combating climate change. However, the adoption of solar energy is but a stepping stone towards maritime sustainability, as the integration of CO2 capture, utilization, and storage (CCUS) technologies promises to amplify the industry's environmental impact to unprecedented heights.

In the context of the French tertiary decree, it is crucial to reduce the energy consumption of buildings by first addressing the design of the electrical architecture. Implementing Direct Current (DC) nanogrids in buildings could offers a promising advantage for energy efficiency, significantly impacting overall energy consumption and sustainability goals. For an insulated area with a subtropical climate, such as La Réunion island, DC nanogrids could also facilitate the insertion of local renewable energy sources, especially solar energy. This article presents the deployment and efficiency evaluation of an end-to-end Low Voltage Direct Current (LVDC) nanogrid, from conception to real-world installation within a company. The nanogrid consists of a photovoltaic power plant, a Lithium-Iron-Phosphate (LFP) battery, and DC end-use equipment such as LED lighting and DC fans for two individual offices. An innovation is provided for the power supply and energy management of terminal equipment using the Power Over Ethernet (PoE) standard IEEE 802.3bt. The efficiency of the nanogrid is measured to be 40% higher than the efficiency of an installation powered by PV and distributed at 230 VAC. These results are obtained under certain deployment conditions, which are discussed in this article, in order to enhance the energy efficiency of buildings by using 48VDC. The nanogrid hardware and software infrastructure, the methodology employed for efficiency quantification and the measurement results are described in the paper.

The binary metal oxide mesoporous interfacial layers (bi-MO meso IF layer) templated by a graft copolymer is synthesized between a fluorine-doped tin oxide (FTO) substrate and nanocrystalline TiO2 (nc-TiO2). Amphiphilic graft copolymers, Poly(epichlorohydrin)-graft-poly(styrene), PECH-g-PS, was used as a structure-directing agent, and the fabricated bi-MO meso IF layer exhibits good interconnectivity and high porosity. Even if the amount of ZnO in bi-MO meso IF layer increased, it was confirmed that the morphology and porosity of bi-MO meso IF layer was well maintained. In addtion, bi-MO meso IF layer coated onto FTO substrates show higher transmittance compared with a pristine FTO substrate and dense-TiO2/FTO, due to the reduced surface roughness of FTO. The overall conversion efficiency (η) of a solid state photovoltaic cells, dye-sensitized solar cell (DSSC) fabricated with nc-TiO2 layer/bi-MO meso IF layer TZ1 used as a photoanode reaches 5.0% at 100 mW cm-2, which is higher than that of DSSC with a nc-TiO2 layer/dense-TiO2 layer (4.2%), resulting from enhanced light harvesting, good interconnectivity, and reduced interfacial resistance. The cell efficiency of the device did not change after 15 days, indicating that the bi-MO meso IF layer with solid-state electrolyte has improved electrode/electrolyte interface and electrochemical stability. Additionally, commercial scattering layer/nc-TiO2 layer/bi-MO meso IF layer TZ1 photoanode fabricated solid state photovoltaic cells (DSSC) achieved an overall conversion efficiency (η) of 6.4% at 100 mW cm-2.

Glypicans are a family of heparan sulfate proteoglycans that are attached to the outer plasma membrane leaflet of the producing cell by a glycosylphosphatidylinositol anchor. Glypicans are involved in the regulation of many signalling pathways, including those that regulate the activities of Wnts, Hedgehog (Hh), Fibroblast Growth Factors (FGFs) and Bone Morphogenetic Proteins (BMPs), among others. In the Hh signalling pathway, glypicans have been shown to be essential for ligand transport and the formation of Hh gradients over long distances, for the maintenance of Hh levels in the extracellular matrix and for its unimpaired reception in distant recipient cells. Recently, two mechanistic models have been proposed to explain how Hh can form the signalling gradient and how glypicans may contribute to it. In this review, we describe the structure, biochemistry and metabolism of glypicans and their interactions with different components of the Hh signalling pathway that are important for the release, transport and reception of Hh.

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that acts on the pancreas to increase insulin and decrease glucagon secretion. Albuminuria is the pivotal marker for diabetic nephropathy, which is the leading microvascular complication of diabetes mellitus. Most of the previous studies mainly focused on the clinical trials of the therapeutic renal protective effect after administration of GLP-1 receptor agonists (GLP-1 RAs), not prior to administration. Therefore, this study aimed to investigate the association between fasting plasma GLP-1 levels and albuminuria before GLP-1 RA administration. A cross-sectional study was designed to evaluate the association between fasting plasma GLP-1 levels and albuminuria in patients with type 2 diabetes mellitus (T2DM). A total of 68 T2DM participants were analyzed from the data at Wonkwang University Hospital in Iksan, Korea. Logistic regression analysis was performed to evaluate the odds ratio (OR) and 95% confidence interval (CI) of the incidence of albuminuria between the GLP-1 low group (Group L) and the high group (Group H). The OR (95% CI) for the incidence of albuminuria comparing the Group L with the Group H of fasting plasma GLP-1 levels was 3.410 (1.160-10.023), p = 0.026 after adjustment for age, gender, fasting plasma glucose, HbA1c, C-peptide, the use of ACE inhibitors or ARBs, SGLT-2 inhibitors, and DPP-4 inhibitors. As a continuous variable, the OR (95% CI) for the incidence of albuminuria associated with the reduction of each 1 pmol/L in fasting plasma GLP-1 levels was 1.673 (1.173-1.870), p = 0.018, after full adjustment. This study showed the negative association between fasting plasma GLP-1 levels and the incidence of albuminuria in Korean patients with T2DM, before GLP-1 RA administration. This result suggests that endogenous GLP-1 may play a role in attenuating albuminuria.

The evolution of photovoltaic cells is intrinsically linked to advancements in the materials from which they are fabricated. This review paper provides an in-depth analysis of the latest developments in silicon-based, organic, and perovskite solar cells, which are at the forefront of photovoltaic research. We scrutinize the unique characteristics, advantages, and limitations of each material class, emphasizing their contributions to efficiency, stability, and commercial viability. Silicon-based cells are explored for their enduring relevance and recent innovations in crystalline structures. Organic photovoltaic cells are examined for their flexibility and potential for low-cost production, while perovskites are highlighted for their remarkable efficiency gains and ease of fabrication. The paper also addresses the challenges of material stability, scalability, and environmental impact, offering a balanced perspective on the current state and future potential of these material technologies.

Biofilm-associated bacterial infections are the major reason for treatment failure in many diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria leads to materiality, tissue damage and chronic diseases. Specialized proresolving mediators (SPMs), including maresin-like lipid mediators (MarLs), are enzymatically biosynthesized from omega-3 essential long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA) by macrophages and other leukocytes. SPMs exhibit strong inflammation-resolving activities, especially inflammation provoked by bacterial infection. In this study, we explored the potential direct inhibitory activities of three MarLs on gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria in their biofilms that are leading bacteria in burn trauma related infections. We also examined the effects of MarLs on the bactericidal activities of a typical broad-spectrum antibiotics carbenicillin on these bacteria in their preformed biofilms. The results revealed that MarLs combined with carbenicillin can inhibit the survival of gram-positive and gram-negative bacteria in their biofilms although MarLs alone did not exhibit bactericidal activity. Thus, our findings suggest that the combination of MarLs and carbenicillin can lower the antibiotic requirements to kill the bacteria in preformed biofilms.

This paper aims to study the performance of solar collectors with various sizes under different weather conditions of different Japanese cities, i.e. Kofu city, Nagoya city and Yamagata city. The heat generated from the solar collector was used to conduct a biogas dry reforming reactor in order to produce H2 to feed a solid oxide fuel cell (SOFC). This study has revealed that the output temperature of solar collector, Tfb in April and July was higher than that in January and October irrespective of city. The optimum length of absorber (dx) of the collector was 4 m irrespective of city. It was clarified that Tfb in Yamagata city in January and October, i.e. winter and autumn is lower than that in Kofu city and Nagoya city especially, which is influenced by the tendency of a solar intensity (I) strongly, not velocity of surrounding air (ua). On the other hand, Tfb is almost the same in April and July, i.e. spring and summer, irrespective of city. The amount of produced H2 from the biogas dry reforming reactor and the power generated by SOFC using H2 in spring and summer were higher compared to the other seasons irrespective of city. This study has revealed that the highest available households number per month was 4.7 according to the investigation in this study.

Diamond-like carbon (DLC) layers are known for their high corrosion and wear resistance, low friction, and high biocompatibility. However, it is often necessary to dope DLC layers with additional chemical elements to strengthen their adhesion to the substrate. Ti-DLC layers (doped with 0.4, 2.1, 3.7, 6.6, 12.8 at.% of Ti) were prepared by dual pulsed laser deposition, and pure DLC, glass, and polystyrene (PS) were used as controls. In vitro cell-material interactions were investigated with an emphasis on cell adhesion, proliferation, and osteogenic differentiation. We observed slightly increasing roughness and contact angle and decreasing surface free energy on Ti-DLC layers with increasing Ti content. Three-week biological experiments were performed using adipose tissue-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (bmM-SCs) in vitro. The cell proliferation activity was similar or slightly higher on the Ti-doped materials than on glass and PS. Osteogenic cell differentiation on all materials was proved by collagen and osteocalcin production, ALP activity, and Ca deposition. The bmMSCs exhibited greater initial proliferation potential and an earlier onset of osteogenic differentiation than the ADSCs. The ADSCs showed a slightly higher formation of focal adhesions, higher metabolic activity, and Ca deposition with increasing Ti content.

The classification of tumors in subtypes, characterized by phenotypes determined by specific differentiation pathways, aids diagnosis and directs therapy towards targeted approaches. However, with the advent and explosion of next-generation sequencing, cancer phenotypes are turning out to be far more heterogenous than initially thought, and the classification is continually being updated to include more subtypes. Tumors are indeed highly dynamic and they can evolve and undergo various changes in their characteristics during disease progression. The picture becomes even more complex when tumor responds to a therapy. In all these cases, cancer cells acquire the ability to trans-differentiate, changing subtype, and adapt to changing microenvironments. These modifications affect the tumor's growth rate, invasiveness, response to treatment, and overall clinical behavior. Studying tumor subtype transitions is crucial for understanding tumor evolution, predicting disease outcomes, and developing personalized treatment strategies. We discuss this emerging hallmark of cancer and the molecular mechanisms involved at the crossroads between tumor cells and their microenvironment, focusing on four different human cancers in which tissue plasticity causes a subtype switch: breast cancer, prostate cancer, glioblastoma and pancreatic adenocarcinoma.

In the field of adaptive building technologies, this research introduces the development of a self-regulating solar shading actuator, that utilizes the thermal shape memory effect. The study places its focus on addressing the actuator’s performance under diverse environmental conditions. Thermal simulations were carried out during the development of the individual components of the actuator and for the prediction of specific switching temperatures. The investigation includes an analysis of the sunshade’s response to varying environmental conditions, emphasizing its effectiveness on clear summer days and identifying challenges during overcast periods. The critical coordination between the solar collector and the shape memory alloy (SMA) wire is examined, shedding light on the impact of SMA temperature dynamics on the actuation performance. Through the integration of simulation data and real-world measurements, the study validates the thermal model for the solar collector, establishing the robustness of the system’s operation. This research work contributes significantly to the development of intelligent actuators and outlines the importance of validation of SMA-based applications under real conditions.

The assessment of photovoltaic devices, which convert light energy into electricity, becomes significantly relevant due to the aspiration to reduce pollution on a global scale. In this context, the pursuit of optimizing the efficiency in converting light energy into electrical energy involves exhaustive studies and structural analyses of solar cells, all directed toward achieving this goal. This study introduces a research proposal aimed at analyzing the losses associated with series resistance (Rs). The analysis takes into account each component comprising this resistance, pro-posing a network of resistances that precisely models each of these elements. The aforementioned research focused on simple-structured crystalline silicon cells. During this investigation, the junction depth (xj) of n-p materials was varied with the aim of achieving efficiencies in the range of 12%. However, in the pursuit of this desired efficiency, a significant impact on series resistance was observed when analyzing the I-V curves of the cells obtained in each manufacturing process.

This study has two main focuses: the first focus is to explore the design and the behavior of a locally built solar dryer during processing henna leaves. This was performed through the determination of the most important parameters that have effect on the drying process. Appropriately, it was found that the outlet air temperature of the solar collector depends entirely on the solar radiation, Moreover, the inlet temperature of the air to the drying chamber has also an important impact on the moisture content of the product. It was found that most of the studies dealing with solar drying do not take into consideration the quality of the final product. Accordingly, the second objective of this study is to present the effect of drying process on the quality of the drier samples. For this purpose, the bioactivity of the samples, in terms of determination of the total phenol content, total flavonoid content, and antioxidant activities was performed. Three different samples: fresh sample, samples dried with the presented solar dryer and open solar dried samples are tested. It was found that samples dried with the solar dryer presented the best results.

We consider the restrictions on photovoltaic (PV) capacity that are caused by limitations on where panels can be sited, and find quantitative evidence for the need for high efficiencies. We define 15% of the UK’s energy consumption as a “significant” contribution and, with London as an exemplar, we perform an idealised calculation that makes the most optimistic possible assumptions about the capabilities of future PV technologies, and use published surveys of energy usage, dwelling type and insolation. We find that covering every UK domestic roof with the highest power-conversion efficiency (PCE) solar panels currently commercially available, could produce up to 9% of the UK's energy. A 15% contribution would require PV technologies with >37% PCE, more than the theoretical Shockley-Queisser limit. Replacing the idealising assumptions with more realistic estimates increases this by 2-3 times. Alternatively, a solar farm using the currently available PCEs would require a politically challenging ~1200km2 of new land, roughly the area of Greater London, for this 15% contribution. We conclude that PCEs must be driven higher even than the Shockley-Queisser limit for PV to play a significant part in carbon mitigation.

The aim of this work is to provide a full description of how air temperature and solar radiation induce changes in the land cover over an Antarctic site. We use shortwave broadband albedo (albedo integrated in the range 300-3000 nm) from a spaceborne sensor and from field surveys to calculate the monthly relative abundance of landscape units. Field albedo data were collected using a portable albedometer over seven landscape units: clean fresh snow; clean old snow; rugged landscape composed of dirty snow with disperse pyroclasts and rocky outcrops; dirty snow; stripes of bare soil and snow; shallow snow with small bare soil patches; bare soil. MODIS MCD43A3 daily albedo product was downloaded using the Google Earth Engine API from the 2000-2001 season to the 2020-2021 season. Each landscape unit was characterized by an albedo normal distribution. The monthly relative abundance of the landscape units were calculated by fitting a linear combination of the normal distributions to the histogram of the MODIS monthly mean albedo. The monthly relative abundance of the landscape unit consisting of rugged landscape composed of dirty snow, with dispersed clasts and small rocky outcrops exhibits a high linear positive correlation with the monthly mean albedo (R2=0.87) and a high linear negative correlation with the monthly mean air temperature (R2= 0.69). The increase of the solar radiation energy flux from September to December coincides with the decrease of the relative abundance of the landscape unit composed of dirty snow with dispersed clasts and small rocky outcrops. We propose a mechanism to describe the evolution of the landscape: uncovered pyroclasts act as melting centres favouring the melting of surrounding snow. Ash does not play a decisive role in the melting of the snow. The results also explain the observed decreasing of the thaw depth of the permafrost on the island in the period 2006-2014, resulting from an increase in the snow cover over the whole island.

The solar heat pump system based on photovoltaic photothermal (PV/T) modules is a new technology that integrates photovoltaics and heat reutilization. It can improve the efficiency of photovoltaic conversion and recovery the remaining heat generated during the photoelectric conversion process, thereby improving the comprehensive efficiency of the whole system. Simulink software is a visual simulation tool, which has the advantages of strong applicability, clear simulation structure and calculation process. The design of its graphical programming greatly simplifies the user modeling process and allows for direct viewing of results, therefore improving the simulation efficiency. At present, there is little research on simulation of solar heat pump systems with PV/T modules based on Simulink software. In this paper, the mathematical models of each component contained in the PV/T solar heat pump system were established based on the system working principle, energy conservation equations and some empirical formulas, and then the operation of the system was simulated by the Simulink software. Due to the operation characteristic of PV/T modules is the key influencing factor for the whole system performance, the model and simulation process for PV/T modules were introduced in detail. The results showed that the surface temperature of PV/T modules under different operating conditions was significantly lower than that of ordinary photovoltaic panels, and the temperature change amplitude was lower. As results, the power generation and photovoltaic conversion efficiency were significantly improved.

Our analysis of previous studies shows that solar energy and wind can consume negligible amount of water to generate one megawatt of electricity.

he paper offers an innovative cooking utensil design for remote, isolated, and even peri-urban communities at a low price, with high reliability and simple construction. It can alleviate energy poverty and improve food security. This utensil uses only local solar energy directly and allows comfortable indoor cooking. This paper provides the design principles of a solar cooker/frying pan or generic heater, based on a PV panel or a plurality of them, which are directly connected to a plurality of Positive Thermal Coefficient (PTC) resistors to match the power. PTCs are nowadays produced in massive quantities and are widely available at low cost. The proposed device does not require an electronic controller or a battery for its operation. The aim is for family use, although the design can be easily scaled to a larger size or power, maintaining its simplicity. Electric heating inside or attached to the cooking pot, plus the temperature self-limiting effect of PTCs, allows for thermally insulating the cooking pot from its outside using ordinary materials. Insulation en-hances energy efficiency during cooking and keeps cooked food warm for a long time. Clean development would receive a significant impulse with its application. A simple mathematical model describes its functioning and states guidelines for adequate design. The results indicate a successful proof of concept and high efficiency both for water and oil as representatives of cooking.

Solar energy adoption worldwide has expanded exponentially due to a surge in international interest in producing clean energy and the declining cost of solar power plants and their technology. It is anticipated that by 2050, solar will have surpassed fossil fuels to become the primary source of energy. However, one of the main challenges associated with solar energy production is the instability of photovoltaic (PV) power generation because of weather changes. Short-term forecasting of the power output of photovoltaic systems is essential for efficient management of the power grid and energy markets. This paper aims to evaluate the ability of deep learning (DL) models to provide accurate forecasting of hourly global horizontal irradiance (GHI) using different sets of features, including weather and aerosol variables along with solar radiation components. The results show that the best forecast skills are achieved by the long short-term memory autoencoder (LSTM-AE) model.

In this study, we once again use a set of Fibonacci-like sequences to examine the symmetries within the genetic code. This time, our focus is on the physiological state of the amino acids, considering them as charged, in contrast to our previous work where they were seen as neutral. In a pH environment around 7.4, there are four charged amino acids. We utilize the properties of our sequences to accurately describe the symmetries in the genetic code table. These include Rumer’s symmetry, the third-base symmetry and the "ideal" symmetry, along with the "supersymmetry" classification schemes. We also explore the special chemical structure of the amino acid proline, presenting two perspectives—shCherbak’s view and the Downes-Richardson view, which perspectives are included in the description of the above-mentioned symmetries. Our investigation employs also elementary modular arithmetic to precisely describe the chemical structure of proline, connecting the two views seamlessly. Finally, our Fibonacci-like sequences prove instrumental in quickly establishing the multiplet structure of non-standard versions of the genetic code. We illustrate this with an example, showcasing the efficiency of our method in unraveling the complex relationships within the genetic code.

Although solar photovoltaic (PV) system costs have declined, capital cost remains a barrier to widespread adoption. Do-it-yourself (DIY) system designs can decrease costs by about 50% by reducing labor costs, but if not attached to a building structure demand ground penetration for conventional footings. This is not technically and economically feasible at all sites. To overcome these challenges, this study details systems designed to eliminate drilling holes and pouring concrete. Two different designs for both fixed tilt and variable tilt PV racking are investigated to assess their structural integrity, constructability, and economic cost when fabricated with a ballast-supported foundation. The ballast-supported foundations are analyzed for eight such systems by proposing two separate ballast designs: one for single line of post systems, and one for double line of post systems built on a 4-kW basis. The results of the analysis found that both designs are slightly more expensive than typical in-ground concrete systems by 25%, but the overall DIY systems costs remain economically advantageous. Sensitivity analyses are conducted to show how modifications to the dimensions including clearances and distances between gabions influence the weight of the system and thus change the economic value of the design, so users can trade dimensional freedom for cost-savings, and vice versa. Overall, all the wood-based PV racking system designs provide users with cost-effective and easy DIY alternatives to conventional metal racking, and the novel ballast systems presented provide more versatility for PV systems installations.

Efficient implementation of clean energy technologies, including pioneering solutions like mobile solar PV systems mounted on trailers (MSPT), is pivotal for addressing energy challenges, especially in regions with constrained power grid access. This endeavour is vital for meeting escalating elec-tricity demands and aligning with the UN Sustainable Development Goal (SDG) aimed at ensuring dependable and sustainable energy provision in developing countries. This paper investigates the aerodynamic behaviour of a designed MSPT using numerical and experimental approaches. Spe-cifically, the study focuses on the effects of wind velocity and tilt angels on the drag and lift forces, as well as drag and lift coefficients on the panel used in the MSPT system. Additionally, the overall wind force acting on the entire MSPT (including 9 large solar PV panels) was examined, considering the combined effects of wind flow and the system's geometry. The simulations were conducted using ANSYS-Fluent software and experimental testing was performed utilizing scaled-down models to validate the accuracy of the simulation. The insights and the knowledge from this study can be utilized to optimize the design, installation, and operation of such systems, ultimately enhancing their performance, reliability, and paving ways for further improvements in mobile solar PV technology.

This theoretical study presents a novel perspective on the potential anti-inflammatory properties of Bromelain, a natural agent extracted from pineapple stems. The investigation explores the binding capabilities of Bromelain to Apoptosis-associated speck-like containing CARD (ASC), a crucial adapter molecule known for its involvement in inflammatory processes and inflammasome formation. For the first time, these findings suggest that Bromelain exhibits a notable affinity for ASC, indicating its promising role as a natural anti-inflammatory agent. This study sheds light on the molecular interactions that may contribute to Bromelain's therapeutic potential in modulating inflammatory responses.

Novel segmented tick-borne RNA viruses belonging to the group of Jingmenviruses (JMVs) are widespread across Africa, Asia, Europe, and America. In this work, we obtained whole-genome sequences of two Kindia tick virus (KITV) isolates and performed modeling and functional annotation of the secondary structure of 5’ and 3’ UTRs from JMV and KITV viruses. UTRs of various KITV segments are characterized by: (1) polyadenylated 3’ UTRs; (2) 5’ DAR and 3’ DAR motifs; (3) a highly conserved 5’-CACAG-3’ pentanucleotide; (4) a La protein binding site; (5) multiple UAG sites providing interactions with the MSI1 protein; (6) three homologous sequences in the 5’ UTR and 3’ UTR of segment 2; (7) the segment 2 3’ UTR of a KITV/2017/1 isolate comprises two consecutive 40 nucleotide repeats forming a Y-3 structure; (8) a 35-nucleotide deletion in the second repeat of the segment 2 3’ UTR of KITV/2018/1 and KITV/2018/2 isolates, leading to a modification of the Y-3 structure; (9) two pseudoknots in the segment 2 3’ UTR; (10) the 5’ UTR and 3’ UTR are represented by patterns of conserved motifs; (11) the 5’-CAAGUG-3’ sequence occurs in early UTR hairpins. Thus, we identified regulatory elements in the UTRs of KITV, which are characteristic of orthoflaviviruses. This suggests their functional significance for the replication of JMVs and the evolutionary similarity between orthoflaviviruses and segmented flavi-like viruses.

This study aimed to increase the energy independence of buildings by utilizing solar energy to produce renewable energy. The subject of this study was a shading structure installed in an outdoor space to provide solar energy. Solar panels were applied to the shaded structures to generate energy actively. The solar panels were designed to be moved according to the optimal tilt angle each month to produce the optimal renewable energy. The architectural design of the shading structure and the energy simulation of the solar panels were conducted using a parametric design. The results of the energy simulation showed the generation of 31,570 kWh· year−1 of renewable energy. This amount of energy is 10% higher than that produced by fixed solar panels. Thus, the moving solar panel system developed in this study not only increases the energy independence of buildings, but also has the advantage of higher renewable energy production compared with fixed solar panels. Additionally, various types of shading structures can be designed depending on the combination of solar panel modules; in particular, moving solar panels have the potential to facilitate ecofriendly designs when applied to the exterior of buildings.

In this work, the optoelectronic characteristics of kesterites of the Cu₂NiXS₄ system (X = Si, Ge, Sn) were studied. The electronic properties of the Cu₂NiXS₄ (X = Si, Ge, Sn) system were studied using first-principles calculations within the framework of density functional theory. For calculations, ab initio codes VASP and Wien2k were used. The high-precision modified Beke-Jones (mBJ) functional and the hybrid HSE06 functional were used to estimate the bandgap, electronic and optical properties. Calculations have shown that when replacing Si with Ge and Sn, the band gap decreases from 2.58 eV to 1.33 eV. Replacing Si with Ge and Sn reduces the overall density of electronic states. In addition, new deep (shallow) states are formed in the band gap of these crystals, which is confirmed by the behavior of their optical properties. The obtained band gap values are compared with existing experimental measurements, demonstrating good agreement between HSE06 calculations and experimental data. The nature of changes in the dielectric constant, absorption capacity and optical conductivity of these systems depending on the photon energy has also been studied. The statistical dielectric constant and refractive index of these materials were found. The results will help increase the amount of information about the properties of the materials under study and will allow the use of these compounds in a wider range of optoelectronic devices, in particular, in solar cells and other devices that use solar radiation to generate electric current.

The utilization of solar energy technology is crucial for generating hydrogen in sustainable energy systems. While traditional methods involving natural gas, coal, and oil have been employed for hydrogen production, this study aims to explore environmentally friendly techniques. Green hy-drogen, despite being a more expensive option compared to fossil fuel-derived hydrogen, has prompted engineers to develop affordable and low-carbon technologies. The microgrid model was developed to showcase a self-contained DC islanded system designed to supply power to an electrolyzer, capitalizing on both a solar array and an energy storage unit. This comprehensive model offers a versatile platform for evaluating the operational dynamics involved in the sustainable production of green hydrogen. Over a span of seven days, it permits the as-sessment of hydrogen generation characteristics through the utilization of solar energy, either di-rectly from a solar array or through an integrated system that incorporates energy storage. The model encompasses a multi-domain framework, encompassing electrical, thermal liquid, and thermal gas aspects, facilitating a holistic exploration of the intricate processes underlying the green hydrogen production system. Through this simulation, the feasibility and efficiency of harnessing renewable energy sources for hydrogen production in an off-grid setting can be comprehensively examined and optimized, contributing to the advancement of sustainable energy solutions.

Solar photovoltaic systems (PVs) are becoming more popular in Poland, as the country aims to increase its share of renewable energy sources and reduce its dependence on coal. According to the official data the total installed PV capacity in Poland reached 15.6 GW in September 2023 while at the end of 2020 it was 4.1 GW. This situation was caused by many factors, but mainly by government subsidy programs for households and rising electricity prices. A number of photovoltaic installations with a capacity of up to 50 kWp were carried out, although the installation should always be adapted to the needs of a given household. Estimating the yield of solar energy systems is crucial for that. It can be done by several methods, but always as initial step in modelling of solar energy systems weather data, especially solar irradiation is required. To get this data we can arrange the measurement from ground stations or use reanalysis models and satellite-derived datasets. There are several different datasets, both public and commercial, of solar irradiance data ready to use. This data provides insights into the average solar irradiance levels throughout the year, aiding in estimating the energy generation capacity. The paper contributes the knowledge of energy generation capacity that can be quickly counted for a solar PV micro-system with different orientation and inclination as a multiplier of the energy value obtained from a solar PV system of 1 kW-peak for a significant number of locations in Poland based on open-source solar irradiation data

The transition region is a very thin but most peculiar layer in the solar atmosphere, located between the solar chromosphere and the corona. It is a key region for understanding the coronal heating, the solar eruptions triggering, and the origin of solar winds. Here, the gradients of all physical parameters are very high, including plasma density, ionization degree, temperature, and magnetic fields, etc. Therefore, the transition region should be highly dynamic, such as fast energy releasing and transporting, plasma heating, and even particle accelerating. They include two physical aspects: thermal and non-thermal processes. The thermal processes can be observed from the ultraviolet (UV) and extreme ultraviolet (EUV) emission by multi-wavelength images. The non-thermal processes, however, should be related to radio emissions especially at millimeter wavelengths, and the frequency range should span from several GHz to beyond 300 GHz, and the emission mechanism should be highly related to the magnetic fields and variations. The ultra-wide broadband spectral observations at millimeter wavelengths with high spectral resolutions may provide rich dynamic information about the transition region, such as non-thermal energy release and transmission, the flows of plasma and energetic particles, the magnetic fields and their variations, the generation and transportation of various waves, and the formation and evolution of the source regions of solar eruptions. Here, we discussed the spectral characteristics of millimeter-wave emission from the transition region and proposed a new conception of ultra-wide broadband millimeter-wave spectrometers to observe them.

This study advances the field of solar irradiance nowcasting by introducing a discrete-level classification approach, diverging from traditional continuous measurement methods. Grounded in a need for cost-effective and modular solutions, the research employs high-resolution computer vision coupled with a deep learning framework to predict Direct Normal Irradiance (DNI). By harnessing the capabilities of a Logitech C900 1080p HD camera and an NVIDIA Jetson module, the study achieves real-time data processing, pivotal for CSP systems' operational efficiency. The core of the methodology is the ResNet-50 convolutional neural network, refined via transfer learning on a bespoke dataset, culminating in a predictive accuracy of 85.78%. This discrete classification model contrasts with conventional, costly instruments like the MS-57, offering a novel and accessible alternative for DNI estimation. Such innovation not only demonstrates high predictive accuracy but also signifies a shift towards less resource-intensive and more adaptable solar energy forecasting tools, contributing a significant leap towards optimizing renewable energy systems.

Human sepsis is one of the leading cause of death worldwide and is known to be a harmful damaging host inflammatory condition, primarily caused by endotoxin released by gram-negative bacteria. Despite antibiotics administration being widely used to treat disease, effective targeted therapeutic strategies for the sepsis are still lacking. Here, we demonstrate that CM1, a derivative of natural polyphenol chrysin, exerts anti-inflammatory activity by inducing the ubiquitin-editing protein TNFAIP3 and NAD-dependent deacetylase sirtuin 1 (SIRT1). We found that CM1 attenuated Toll-like receptor 4 (TLR4)-induced the generation of inflammatory cytokines by inhibiting the extracellular-signal-regulated kinase (ERK)/MAPK and nuclear factor kappa B (NF-κB) signaling pathway. In addition, the treatment of macrophages with CM1 induced the expression of TNFAIP3 and SIRT1 in TLR4-stimulated primary macrophages, however the anti-inflammatory properties of CM1 was disappeared by siRNA silencing of TNFAPI3 or by the genetic and pharmacologic inhibition of SIRT1. Importantly, intravenously administration of CM1 resulted in the decreased susceptibility to endotoxin-induced sepsis, leading to inhibition of the generation of proinflammatory cytokines and neutrophils infiltration into lung than control mice. Collectively, these findings suggest that CM1 has the potential to be a treatment candidate for diverse inflammatory diseases including sepsis.

The perovskite solar cells (PSCs) have been significantly improved by utilizing inorganic hole transporting layer (HTL), such as nickel oxide. Despite the promising properties, there are still limitations due to defects. Recently, research on self-assembled monolayers (SAM) is being actively conducted, which show promise in reducing defects and enhancing device performance. In this study, we successfully engineered a p-i-n perovskite solar cell structure utilizing HC-A1 and HC-A4 molecules. These SAM molecules were found to enhance the grain morphology and uniformity of the perovskite film, which are critical factors in determining optical properties and device performance. Notably, HC-A4 demonstrated superior performance due to its distinct hydrophilic properties with a contact angle of 50.3°, attributable to its unique functional groups. Overall, the HC-A4 applied film exhibited efficient carrier extraction properties, attaining a carrier lifetime of 117.33 ns. Furthermore, HC-A4 contributed the superior device performance with its favorable band alignment, achieving the highest device efficiency of 20%.

The energy transition to wind and solar opens opportunities for green hydrogen as the wind and solar generation tends to bring electricity prices down to very low levels. This paper evaluates whether green hydrogen can integrate well with wind and solar PV to help with improved management of the South Australian electricity grid. Green hydrogen can use membrane electrolysis plants during surplus renewable energy periods. This hydrogen can then be electrified or used in industry. The green hydrogen system was analysed to understand the financial viability and technical impact of integrating green hydrogen. We also used systems engineering techniques to understand the system holistically, including the technical, social, environmental, and economic impacts. The results show opportunities for the system to provide seasonal storage, grid firming, and reliability services. Financially, it would need changes to electricity rules to be viable, but without those changes, our modelling suggested it would be financially viable within this decade

The global increase in population, the phenomenon of climate change, the issue of water pollution and contamination, and the inadequate management of water resources all exert heightened strain on freshwater reserves. The potential utilization of the interfacial solar steam generation (ISSG) system, which utilizes photothermal conversion to generate heat on material surfaces for wastewater purification and desalination purposes, has been successfully demonstrated. Textile materials based ISSG devices, including (woven, nonwoven and knitting) fabrics and electrospinning membranes, exhibit distinct properties such as rough surface texture, high porosity, significant surface area, exceptional flexibility, and robust mechanical strength. These characteristics, combined with their affordability, accessibility, and economic viability for widespread implementation, make them extremely attractive for applications in SSG. In this review, a comprehensive analysis of emerging concepts, advancements and applications of textile materials (woven, nonwoven, and knitting) fabrics and electro-spun membranes in the ISSG for wastewater purification and desalination is highlighted. We also emphasize significant obstacles and potential prospects in both theoretical investigations and real-world implementations, aiming to contribute to future advancements in the domain of textile based materials interfacial evaporation in wastewater purification and desalination. Furthermore, the drawbacks and the challenges of ISSG systems are also highlighted.

Silver powder, as the primary component of solar silver paste, significantly influences various aspects of paste performance, including printing, sintering, and conductivity. Silver powders prepared using the liquid-phase reduction method exhibit different microstructures depending on whether the growth process is dominated by aggregation or crystalline growth. This study explores the impact of different silver powder microstructures on packing density and sintering activity. It is observed that polycrystalline aggregated silver powder possesses higher surface energy, lower packing density, and greater sintering activity. Investigation into the influence of different silver powders on the electrical conductivity, adhesion, and structural density of silver paste reveals that polycrystalline aggregated silver powder is more suitable for lower sintering temperature pastes, whereas crystalline growth-type silver powder is better suited for higher sintering temperature pastes, resulting in a denser sintered silver layer. Finally, an analysis of the impact of various silver powders on the aspect ratio and electrical performance of solar cell silver grid lines yields higher aspect ratios (0.40) and photoelectric conversion efficiency (19.26%).

The urgency for a shift towards cleaner and more efficient energy alternatives for power generation is underscored by the escalating demand for energy and the detrimental environmental impacts of conventional fossil fuels. In the case of automotive power, electric vehicles are being adopted in many applications, however, challenges remain such as extended charging periods and limited ranges between charges. Therefore, this research study conducts a techno-economic analysis of renewable energy technologies (including solar modules, wind turbines and piezoelectric materials) to augment the efficiency and sustainability of electric buses. The study examines the scope for these technologies to be adopted on double-decker electric buses in London in the United Kingdom. The solar modules are placed on the rooftop and sides of the bus generating 15.9 kWh/day and the wind turbine in the front bumper of the bus generates 8.3 kWh/day. However, the piezoelectric material generated only 22.6 Wh/day, rendering it an impractical inclusion in further analysis. Therefore, both the solar modules and wind turbines combined generate 24.2 kWh/day, which can increase the driving range by 16.3 km per day and this results in savings of 19.36 minutes for charging at the stations. Investing in such projects would have a positive return as the internal rate of return (IRR) and net present value (NPV) are 2.8% and £11,175 respectively. The annual revenue would be £6,712, and the greenhouse gas (GHG) reduction would be two metric tons annually. Electricity exported to the grid, the electricity export rate, and the initial investment are identified as key factors influencing power outage in a sensitivity analysis. In conclusion, this numerical modelling study paves the way for experimental validation towards implementation of renewable energy technologies on electric bus fleets.

In recent years, advancements in rooftop solar panel technology have sparked a revolution in the electricity markets. This has given rise to a new concept of energy exchange - the ability for consumers and producers to trade localized energy. This concept has been made possible by the emergence of blockchain technology, which has gained significant traction in the energy markets. Its unique ability to facilitate peer-to-peer (P2P) energy transactions has made it a promising solution for the trilemma of scalability, security, and decentralization. However, while blockchain technology has shown great potential, it is still in its early stages of development and has yet to reach its full potential. To fully understand the potential of blockchain technology in P2P energy trading, it is important to explore the trilemma in depth. This study proposes a blockchain-based scalability solution, with a focus on P2P energy trade. This strategy is supported by empirical modeling, utilizing data gathered from a trial case study. The results of this study demonstrate that the suggested technique outperforms base layer models in terms of scalability, while still maintaining the essential elements of security and decentralization. This proposed solution not only has the potential to revolutionize the energy markets, but also has broader implications. By providing a more secure and decentralized platform for P2P energy trading, it has the potential to address issues of energy distribution inequality and promote the adoption of renewable energy. With blockchain technology, individuals and communities have the opportunity to take control of their energy usage and production, reducing their reliance on traditional centralized energy systems. This not only has the potential to lower energy costs for consumers, but also contributes to the overall goal of reducing carbon emissions and mitigating the effects of climate change. The combination of rooftop solar panel technology and blockchain applications has the potential to create a significant shift towards decentralized and sustainable energy systems. This will not only benefit individuals and communities, but also have a positive impact on the environment and the global energy market as a whole. However, for this transition to occur, it is crucial that governments and energy companies continue to support and invest in these advancements.

In a recent paper, we extended previous studies on solar-terrestrial relationships by investigating the origin of the March 2012 heatwave in northeast USA. In the present study we check the possible relationship of solar activity with the early March 2012 bad weather in northeast Thrace, Greece. To this end, we examined data from various remote sensing instrumentation monitoring the Sun (SDO satellite), the Interplanetary Space (ACE satellite), the Earth’s magnetosphere (Earth based measurements, NOAA-19 satellite), the top of the clouds (TERRA and AQUA satellites) and the near ground atmosphere. Our comparative data analysis suggests that: (i) the winter-like weather (rainfall, fast winds, decreased temperature) in Thrace started on 6 March 2012, on the same day as the heatwave starting in USA, (ii) during the March 2012 winter-like event in Thrace (6-15 March), the ACE satellite recorded enhanced fluxes of solar energetic particles (SEPs), while SOHO and PAMELA recorded solar protons at very high energies (> 500 MeV), (iii) Thrace experienced particularly intense cyclonic circulation, during periods of magnetic storms on 8 - 10 and 12-13 March, which occurred after the arrival at ACE of two interplanetary shock waves, on March 8 and March 11, respectively, (iv) at the beginning of the two above mentioned periods large atmospheric electric fields were recorded, with values ranging between ~-2000V/m - ~1800V/m on 8 March, (v) the winter-like 8-10 March 2012 weather occurred after the detection of the main SEP event related with a coronal mass ejection released in the interplanetary space as a result of intense solar flare activity observed by SDO on 7 March 2012, (vi) the 8-10 March weather was related with a deep drop of ~630C in the cloud top temperature measured by MODIS/TERRA, which favors strong precipitation. Finally, we analyzed data from the electric power network in Thrace (~410N) and we found, for the first time sudden voltage changes of ~3.5kV in the electric grid in Greece, during the decay phase of the March 2012 superstorm. We discuss the winter-like March 2012 event in Thrace in terms of solar cosmic ray influence on the low troposphere mediated by positive NAO. Finally, we infer that the novel finding of the geomagnetic effects on the electric power grid in Thrace may open a new window into space weather applications research.

The feasibility of replacing the toxic chlorobenzene antisolvent with the environmentally friendly anisole in the fabrication of planar triple cation perovskite solar cells was explored. The successful integration of anisole not only ensures comparable device performance but also contributes to the development of more sustainable and green fabrication processes for next-generation photovoltaic technologies. Nevertheless, to ensure the possibility to achieve well-functioning unencapsulated devices, at any time of the year, with changed temperature and relative humidity, several batches with different cesium concentration were realized. We found that 10% of CsI in the precursor solution makes devices with low hysteresis index and sustained performance stability over a 90-day period both with cholorobenzene and anisole antisolvent. However the use of anisole as a green antisolvent ensures enhanced performance.

The red fox, found on all continents except Antarctica, occupies diverse habitats. In Croatia it is an indigenous wild species with a population density of 0.7 animals per square kilometer. While tumors in wild animals from the Canidae family are scarce, the true prevalence and diversity of tumors are likely underestimated due to limited research. So far, a limited number of tumors were observed among the red fox population, either in their natural habitat or in captivity. As part of the National rabies control program, we examined 1,890 red fox carcasses over a four-year period. Our focus was on identifying abnormalities on the skin and internal organs that suggest potential neoplastic proliferation. Five red foxes, three males and two females, were found to have growths resembling potential tumors. Their age distribution spanned from 2 to 7 years. Microscopic investigation revealed two collagenous hamartomas, two Meibomian gland adenomas and one intra-abdominal teratoma within a cryptorchid testis. This retrospective study aims to provide a comprehensive description of tumor and tumor-like lesions observed in free-range red foxes from Croatia, marking the first research of its kind in Croatia.

The pandemic SARS-CoV-2 continues to evolve to give rise to variants of concern that can escape vaccine-induced immunity. As such, more effective vaccines are urgently needed. In this study, we evaluated virus-like particle (VLP) as a vaccine platform for SAS-CoV-2. The spike, envelope, and membrane proteins of the SARS-CoV-2 Wuhan strain were expressed by a single recombinant baculovirus BacMam and assembled into VLPs in cell culture. The morphology and size of the SARS-CoV-2 VLP as shown by transmission electron microscopy was found to be similar to the authentic SARS-CoV-2 virus particle. In a mouse trial, two intramuscular immunizations of the VLP BacMam with no adjuvant elicited spike-specific binding antibodies in both sera and bronchoalveolar lavage fluids. Importantly, BacMam VLP -vaccinated mouse sera showed neutralization activity against SARS-CoV-2 spike pseudotyped lentivirus. Our results indicated that the SARS-CoV-2 VLP BacMam stimulated spike-specific immune responses with neutralization activity.

Neurodegeneration is becoming one of the leading causes of death worldwide as the population expands and grows older. There is a growing desire to understand the mechanisms behind prion proteins as well as the prion-like proteins that make up neurodegenerative diseases (NDs) including Alzheimer’s Disease (AD). Both amyloid β (Aβ) and hyperphosphorylated tau (p-tau) proteins behave in ways similar to that of the infectious form of the prion protein, PrPSc, such as aggregating, seeding, and replicating under not yet fully understood mechanisms, thus the designation of prion-like. This review aims to highlight the shared mechanisms between prion-like proteins and prion proteins in the structural variations associated with aggregation and disease development. These mechanisms are largely focusing on the dysregulation of protein homeostasis, self-replication, and protein aggregation, and how this knowledge could contribute to diagnoses and treatments for the given NDs.

Origin, mechanics and properties of the Solar System are analysed in the framework of the Complete Relativity theory (by the same author). According to Complete Relativity, everything is relative. Any apparent absolutism (notably invariance to scale of dimensional constants, absolute elementariness, invariance to time) is an illusion stemming from limits imposed by [or on] polarized observers that will inevitably lead to misinterpretation of phenomena (another illusion) occurring on non-directly observable scales or even on observable but distant scales in space or time. If everything is relative, reference frames will exist where particles are planets and where planets are living beings. Earth is, therefore, analysed here in more detail, both as a particle and, as a living evolving being (of, hypothesized, extremely introverted intelligence). The analysis confirms the postulates and hypotheses of the theory (ie. existence of discrete vertical energy levels) with a significant degree of confidence. During the analysis, some new hypotheses have emerged. These are discussed and confirmed with various degrees of confidence. To increase confidence or refute some hypotheses, experimental verification is necessary. Main conclusions that stem from my research and are further confirmed in this paper are: universes are, indeed, completely relative; Solar System is a scaled (inflated, in some interpretations) Carbon isotope with a nucleus in a condensed (bosonic) state and components in various vertically excited states; life is common everywhere, albeit extroverted complex forms are present on planetary surfaces only during planetary neurogenesis; anthropogenic climate change is only a part (trigger from one perspective) of bigger global changes; major extinction events on a surface of a planet are relative extinctions, a regular part of transformation and transfer of life in the process of planetary neurogenesis.

This paper is devoted to the analysis of fluctuations in the solar wind plasma and interplanetary magnetic field parameters observed by Solar Orbiter and WIND spacecraft at different scales, ranging from ~10^3 to 10^7 km. We investigated two long observation intervals when the spacecraft were near the Sun-Earth line, during which the distance between the spacecraft was 0.1 and 0.5 AU respectively. It is analyzed how the fluctuation properties in different types of SW, associated with quasi-stationary and transient solar phenomena, transform on the way from the Sun to the Earth. It is shown that the time series behavior of the bulk speed subject to the least change even at the large distance between the observation points, while the time series of the IMF magnitude, components and proton density were significantly transformed even at the relatively short distance. Regardless of the assumed change in the absolute value of the parameters, the conducted statistical analysis shows that the characteristics of their fluctuations (including the level of intermittency) remains near constant regardless of the distance between the observation points and depends mostly on the type of the solar wind.

Co-delivery of antigens and adjuvants to the same antigen presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNPs) as a tunable vaccine co-delivery platform for TLR7/8 agonists along with the recombinant influenza antigen hemagglutinin H7 (H7) to APCs. A-SNPs of two different sizes (50 and 200 nm) were prepared and coated with INI-4001 at different coating densities, followed by co-adsorption of H7. Both INI-4001 and H7 showed > 90% adsorption to the tested A-SNP formulations. TNF-α and IFN-α cytokine release by human peripheral blood mononuclear cells as well as TNF-α, IL-6, and IL-12 release by mouse bone marrow-derived dendritic cells revealed that the potency of the INI-4001-adsorbed A-SNPs (INI-4001/A-SNP) formulations can be improved relative to aqueous formulation control. This improved potency was dependent on particle size and ligand coating density. In addition, slow-release profiles of INI-4001 were measured from INI-4001/A-SNP formulations in plasma with 30-50% INI-4001 released after 7 days. In vivo murine immunization studies demonstrated significantly improved H7-specific humoral and Th1/Th17-polarized T cell immune responses with no observed adverse reactions. Low-density 50 nm INI-4001/A-SNP elicited significantly higher IFN-γ and IL-17 induction over that of the H7 antigen only group and INI-4001 aqueous formulation controls. In summary, this work introduces an effective and biocompatible SNP-based co-delivery platform that enhances the immunogenicity of TLR7/8 agonist-adjuvanted subunit influenza vaccines.

The influences of doped hole transporting layer (HTL) on the performances of perovskite solar cells were studied. The influences of electrostatic and surface roughness effect by solvent additive doping were compared. The electrostatic effect of solvent additive doping was compared by addition of 1,8-diiodooctane and 1,8-dichlorooctane to the HTL layer. The surface roughness effect of solvent additive doping was examined using atomic force microscopy. The perovskite crystallinity by doping HTL was studied by X-ray diffraction. The conductivity of HTL was measured using four probe methods and was higher for doped devices. Enhanced conductivity of PEDOT:PSS film was also proved using fluorescence emission quenching. Long-term stability of the device was enhanced by doping HTL. The device with solvent additive exhibited much enhanced stability, retained over 80% of the initial PCE for 400 hours, while PCE of the device without solvent additive decreased to less than 80% after 200 hours. A very weak power microwave treatment was used for post-annealing of the fully fabricated devices. Post-annealing enhanced the lifetime of the device. Comparing different size of cells, the device lifetime was decreased as the cell area increased and as the size of the cell increased, the extent of lifetime enhancement by doping was increased.

СrAss-like phages play an important role in maintaining ecological balance in the human intestine microbiome. However, their lifestyle and genetic diversity are still insufficiently studied. In this study, a novel CrAssE-Sib phage genome belonging to the epsilon сrAss-like phage genomes was found. Detailed analysis indicated that CrAssE-Sib encodes unusual proteins – DNA primase, virion RNA polymerase, prophage antirepressor, and transcriptional repressor, as well as reverse transcriptase (RT) and receptor binding protein (RBP) that are part of diversity-generating retroelement (DGR). Comparative analysis showed that all epsilon сrAss-like phages are divided into two putative genera, which were proposed to name Epsilonunovirus and Epsilonduovirus; CrAssE-Sib belongs to the first of them. RT from CrAssE-Sib and several Epsilonunoviruses contains a specific motif in its fourth domain that was not previously found in RTs from phage and bacterial DGRs. In addition, RBP from CrAssE-Sib and all Epsilonunoviruses has a unique structure. The presence of the conservative prophage repressor and anti–repressors that belong to the lysogenic-to-lytic cycle switches indicate that CrAssE-Sib and other Epsilonunoviruses could be temperate. Epsilon сrAss-like phage substantially differ from other crAss-like phages, including zeta сrAss-like phages. This fact indicates the need to isolate these phages into a separate family.

Space exploration introduces astronauts to many challenges such as space radiation and microgravity. Researchers have investigated vitamin C as a potential radiation mitigator and antioxidants for sustaining astronaut health. Building on our own studies, which indicate vitamin C's life-saving radioprotective effects and its potential as a radiation mitigator, our research highlights its promise, even when administered 24 h post-exposure. This is particularly relevant in scenarios where astronauts may be exposed to sudden large solar particle events, potentially resulting in lethal doses of space radiation. The success of vegetable cultivation on the International Space Station using NASA's Veggie system offers fresh, vitamin C-rich food. While approved supplements address somatic function, further research is needed to optimize vitamin C's efficacy in humans and develop antioxidant cocktails for space missions. The variable vitamin C content in vegetables underscores the necessity for utilization of artificial intelligence (AI) to assist astronauts in selecting and cultivating vitamin C-rich vegetables that are best suited to combat high levels of space radiation and microgravity. Particularly, AI algorithms can be utilized in analyzing various factors such as nutritional content, growth patterns, and cultivation methods. In conclusion, vitamin C shows significant potential for mitigating space radiation, and ongoing research aims to enhance astronaut health through optimal dietary strategies.

Cork oak mortality has reached alarming proportions in the last decades, exacerbated by climate change. Understanding this phenomenon is crucial in finding mitigation or adaptation strategies. This study conducts a diachronic analysis of cork oak mortality over 10 years using GIS tools, focusing on Portugal's Tagus Lezíria region. Topographic, edaphic and climatic variables were employed to create maps of edaphoclimatic aptitude for cork oaks. Dead trees were identified using remote sensing techniques and crown coverage was determined to calculate the mortality index. The diachronic analysis aimed to explore climate change effects on cork oak mortality. A decrease in precipitation was observed, significantly impacting stands with canopy cover below 40%. Furthermore, a negative effect of solar radiation identified only in stands with canopy cover of 40% suggested its role in cork oak decline. This study introduces a novel perspective, highlighting the protective effect of denser canopy cover (above 40%) against excessive solar radiation and the impact of reduced precipitation. The integrated and diachronic approach provides valuable information for adapting management strategies to climate change challenges.

Nonlinear compression of narrow-band (Δ ≈ 0.2 cm-1) 20 ns KrF laser pulses in SF6 at 10 atm and CH4 at 50 atm pressure was studied. Both SBS and SRS optically phase conjugated backward reflected radiation was registered with energy reflectivity 10−14% in SF6 and CH4. In SF6 SBS pulses gradually shortened from 10 ns to 2−3 ns with pumping decrease to the SBS threshold ~ 10 mJ, while the SRS pulse had the shortest length of 30−60 ps for the maximal pumping of 120 mJ and broadened near the SRS threshold of ~30 mJ. For the SRS pulse energy ~ 2 mJ peak power 5×107 W was tenfold higher than the pump power. The theoretical model predicted a soliton-like SRS pulse compression to a temporal length of the order of vibrational relaxation time. There was no pulse compression of backward SBS and SRS radiation in CH4, while in the forward direction SRS pulses shortened to 3−4 ns at reduced pumping.