Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Bactericidal Efficacy of the Combination of Maresin-like Pro-resolving Mediators and Carbenicillin Action on Biofilm-Forming Burn-Trauma Infection Related Bacteria

Anbu Mozhi Thamizhchelvan
ORCID logo ,
Abdul-Razak Masoud
,
Shanchun Su
ORCID logo ,
Hongying Peng
,
Yuichi Kobayashi
ORCID logo ,
Yu Wang
,
Nathan Archer
ORCID logo ,
Song Hong
*
Version 1 : Received: 26 January 2024 / Approved: 29 January 2024 / Online: 29 January 2024 (05:46:04 CET)

A peer-reviewed article of this Preprint also exists.

Thamizhchelvan, A. M., Masoud, A. R., Su, S., Lu, Y., Peng, H., Kobayashi, Y., ... & Hong, S. (2024). Bactericidal Efficacy of the Combination of Maresin-like Proresolving Mediators and Carbenicillin Action on Biofilm-Forming Burn Trauma Infection-Related Bacteria. International Journal of Molecular Sciences, 25(5), 2792. Thamizhchelvan, A. M., Masoud, A. R., Su, S., Lu, Y., Peng, H., Kobayashi, Y., ... & Hong, S. (2024). Bactericidal Efficacy of the Combination of Maresin-like Proresolving Mediators and Carbenicillin Action on Biofilm-Forming Burn Trauma Infection-Related Bacteria. International Journal of Molecular Sciences, 25(5), 2792.

Abstract

Biofilm-associated bacterial infections are the major reason for treatment failure in many diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria leads to materiality, tissue damage and chronic diseases. Specialized proresolving mediators (SPMs), including maresin-like lipid mediators (MarLs), are enzymatically biosynthesized from omega-3 essential long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA) by macrophages and other leukocytes. SPMs exhibit strong inflammation-resolving activities, especially inflammation provoked by bacterial infection. In this study, we explored the potential direct inhibitory activities of three MarLs on gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria in their biofilms that are leading bacteria in burn trauma related infections. We also examined the effects of MarLs on the bactericidal activities of a typical broad-spectrum antibiotics carbenicillin on these bacteria in their preformed biofilms. The results revealed that MarLs combined with carbenicillin can inhibit the survival of gram-positive and gram-negative bacteria in their biofilms although MarLs alone did not exhibit bactericidal activity. Thus, our findings suggest that the combination of MarLs and carbenicillin can lower the antibiotic requirements to kill the bacteria in preformed biofilms.

Keywords

Maresin-like (MarL); specialized proresolving mediators (SPMs), antimicrobial lipids; fatty acids; bactericidal antibacterial; antimicrobial resistance; microbial infections; biofilms; gram-positive; gram-negative

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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