PreprintArticleVersion 2Preserved in Portico This version is not peer-reviewed
In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors
Version 1
: Received: 8 March 2024 / Approved: 11 March 2024 / Online: 11 March 2024 (13:11:59 CET)
Version 2
: Received: 12 March 2024 / Approved: 13 March 2024 / Online: 14 March 2024 (07:56:20 CET)
How to cite:
Garcia-Loredo, J.A.; Santoyo-Suarez, M.G.; Rodríguez-Nuñez, O.; Benitez Chao, D.F.; Garza-Treviño, E.N.; Zapata-Morín, P.A.; Padilla-Rivas, G.R.; Islas, J.F. In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors. Preprints2024, 2024030607. https://doi.org/10.20944/preprints202403.0607.v2
Garcia-Loredo, J.A.; Santoyo-Suarez, M.G.; Rodríguez-Nuñez, O.; Benitez Chao, D.F.; Garza-Treviño, E.N.; Zapata-Morín, P.A.; Padilla-Rivas, G.R.; Islas, J.F. In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors. Preprints 2024, 2024030607. https://doi.org/10.20944/preprints202403.0607.v2
Garcia-Loredo, J.A.; Santoyo-Suarez, M.G.; Rodríguez-Nuñez, O.; Benitez Chao, D.F.; Garza-Treviño, E.N.; Zapata-Morín, P.A.; Padilla-Rivas, G.R.; Islas, J.F. In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors. Preprints2024, 2024030607. https://doi.org/10.20944/preprints202403.0607.v2
APA Style
Garcia-Loredo, J.A., Santoyo-Suarez, M.G., Rodríguez-Nuñez, O., Benitez Chao, D.F., Garza-Treviño, E.N., Zapata-Morín, P.A., Padilla-Rivas, G.R., & Islas, J.F. (2024). In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors. Preprints. https://doi.org/10.20944/preprints202403.0607.v2
Chicago/Turabian Style
Garcia-Loredo, J.A., Gerardo R. Padilla-Rivas and Jose Francisco Islas. 2024 "In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors" Preprints. https://doi.org/10.20944/preprints202403.0607.v2
Abstract
The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs). This study centers on the intricate interplay between the CACCC-box and its binding proteins such as: the Krüppel-like family (KLF) of transcription factors as primary effectors in the context of CVDs. Our analysis was through a bioinformatics approach, which reveal significant transcriptional activity among KLF subgroup 2, exhibiting the highest number of interactions focusing on the established roles: pluripotency, cancer, and cardiovascular development and diseases. Our analysis reveals KLF's interactions with GATA4, MEF2C, NKX2.5 and other ~ 90 potential genes that participate in the regulation of the hypertrophic environment (or CVD's Environment). Also, the GO analysis showed genes containing the motif CACCC were enriched for multiple CVD’s, in combination with STRING analysis these results pointed to a link between KLFs and these diseases. The analysis further identifies other potential CACCC-box binding factors, such as SP family members, WT1, VEZF1, and -SALL4, which are implicated in cardiac contraction, remodeling, and inflammation processes.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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