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Preprint ARTICLE | doi:10.20944/preprints202305.1852.v1

Beyond Bullying, Aggression, Discrimination, Social Safety: Development of an Integrated Negative Work Behavior Questionnaire (INWBQ)

Cokkie Verschuren, Maria Tims, Annet H. De Lange

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: diagnostic instrument; employee wellbeing; harm; Negative Work Behavior (NWB); bystander roles

Online: 26 May 2023 (04:41:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1708.v1

Cytoplasmic Membrane Homeostasis is Important for the Pathogenicity of Pathogenic Fungi

Yuejin Peng, Bin Chen

Subject: Biology And Life Sciences, Life Sciences Keywords: Cytoplasmic membrane homeostasis; Pathogenicity; Pathogenic fungi; Membrane lipid metabolism; Membrane curvature; Transmembrane protein; Cell wall components; Cytoskeleton; Growth and development; Host infection

Online: 24 May 2023 (10:38:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1664.v1

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Shanisa Naidoo, Arnold M Zwane, Ahmed Paruk, Timothy Craig Hardcastle

Subject: Medicine And Pharmacology, Surgery Keywords: Soft tissue; necrotizing infection; water borne; vibrio; fungal; aeromonas; debridement; negative pressure wound care

Online: 23 May 2023 (14:43:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1575.v1

Application of Heisenberg’s Uncertainty Principle in the Diag-Nostic Dilemma of Children With Acute Appendicitis: Negative Appendectomy Versus Complicated Appendicitis Rates

Stylianos Roupakias, Sotirios Fouzas, Eirini Kostopoulou, Despoina Gkentzi, Theodore Dassios, Ioannis Spyridakis, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Surgery Keywords: complicated appendicitis; negative appendectomy; Heisenberg’s principle; diagnostic uncertainty; children

Online: 23 May 2023 (04:58:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0858.v1

Mortality Due to Multi-Drug Resistant Gram Negative Bacteremia in an Endemic Region: No Better than Toss a Coin

Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Gram-negative bacilli bacteremia; multidrug resistance; 28-day mortality; procalcitonin; rapid molecular diagnostics

Online: 11 May 2023 (13:34:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0770.v1

NUVO Model for the Grand Unified Theory Initial Formalization Part I: Cosmic Scale

Rickey Austin

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: General Relativity; Special Relativity; Newtonian Mechanics; time dilation; theory; inertia; orbital advance; light path curvature; Planck Units; NUVO

Online: 10 May 2023 (14:50:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0526.v1

Immuno-Contexture and Immune Checkpoint Molecule Expression in Microsatellite Stable/Mismatch Repair Proficient Colorectal Carcinoma

Mauro Giacomelli, Matilde Monti, Diego Cesare Pezzola, Silvia Lonardi, Mattia Bugatti, Francesco Missale, Rossella Cioncada, Laura Melocchi, Viviana Giustini, Vincenzo Villanacci, Carla Baronchelli, Stefania Manenti, Luisa Imberti, Emanuele Giurisato, William Vermi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Colorectal cancer; mismatch repair; microsatellite instability; immune checkpoint; double negative T cells; tumor microenvironment; T-cell exhaustion; interferon-γ; PD-L1

Online: 8 May 2023 (10:53:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0146.v1

Revolutionizing Prosthetic Design with Auxetic Metamaterials: A Review of Mechanical Properties and Limitations

Muhammad Faris Fardan, Bhre Wangsa Lenggana, U Ubaidillah, Seung-Bok Choi, Didik Djoko Susilo, Sohaib Z. Khan

Subject: Engineering, Mechanical Engineering Keywords: prosthetic devices; metamaterials; auxetic structure; negative Poisson’s ratio; metastructure

Online: 3 May 2023 (12:31:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1139.v1

On the Jacobi Stability of Two SIR Epidemic Patterns With Demography

Florian Munteanu

Subject: Computer Science And Mathematics, Mathematics Keywords: SIR pattern; KCC theory; the deviation curvature tensor; Jacobi stability

Online: 28 April 2023 (07:57:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0429.v1

Call for Urgent Regulations on Artificial Intelligence

Pavlo O. Dral, Arif Ullah

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial intelligence; Super Artificial intelligence; ChatGPT; ChatGPT-4; AI harm; Negative impacts of AI; AI use in Weapons; AI-driven unemployment; AI use in research

Online: 17 April 2023 (09:06:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0268.v1

Identification of Influential Features for User Engagement with Wellness Content: Analysis of nyt_well Instagram Account

Seungjun Kim

Subject: Public Health And Healthcare, Other Keywords: wellness; health; user engagement; social media; instagram; negative binomial regression

Online: 12 April 2023 (09:46:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0338.v1

On the Cosmic Evolution of the Quantum Vacuum Using Two Variable G Models and Winterberg's Thesis

Christopher Pilot

Subject: Biology And Life Sciences, Horticulture Keywords: Winterberg model; Planck particles; positive and negative mass Planck particles; planckions; quantum vacuum; space as a superfluid/ supersolid; extended models for space; cosmological constant; Higgs field as a composite particle; Higgs boson; inherent length scale for the vacuum; dark energy; cosmological scaling behavior for the quantum vacuum; variable G models; extended gravity; Newton’s constant as an order parameter; high energy behavior for the vacuum

Online: 20 March 2023 (03:40:46 CET)

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We work within a Winterberg framework where space, i.e., the vacuum, consists of a two component superfluid/super-solid made up of a vast assembly (sea) of positive and negative mass Planck particles, called planckions. These material particles interact indirectly, and have very strong restoring forces keeping them a finite distance apart from each other within their respective species. Because of their mass compensating effect, the vacuum appears massless, charge-less, without pressure, net energy density or entropy. In addition, we consider two variable models, where, , is Newton’s constant, and, , increases with an increase in cosmological time. We argue that there are at least two competing models for the quantum vacuum within such a framework. The first follows a strict extension of Winterberg’s model. This leads to nonsensible results, if increases, going back in cosmological time, as the length scale inherent in such a model will not scale properly. The second model introduces a different length scale, which does scale properly, but keeps the mass of the Planck particle as, the Planck mass. Moreover we establish a connection between ordinary matter, dark matter, and dark energy, where all three mass densities within the Friedman equation must be interpreted as residual vacuum energies, which only surface, once aggregate matter has formed, at relatively low temperatures. The symmetry of the vacuum will be shown to be broken, because of the different scaling laws, beginning with the formation of elementary particles. Much like waves on an ocean where positive and negative planckion mass densities effectively cancel each other out and form a zero vacuum energy density/ zero vacuum pressure surface, these positive mass densities are very small perturbations (anomalies) about the mean. This greatly alleviates, i.e., minimizes the cosmological constant problem, a long standing problem associated with the vacuum.

Preprint REVIEW | doi:10.20944/preprints202303.0301.v1

Autochthonous Cultures to Improve Safety and Stabilize Quality of Traditional Dry Fermented Meats

Franca Rossi, Patrizia Tucci, Ilaria Del Matto, Lucio Marino, Carmela Amadoro, Giampaolo Colavita

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: traditional dry fermented sausages; protection policy; desired microbiota; lactic acid bacteria; coagulase negative staphylococci; autochthonous cultures; safety; sensory quality

Online: 16 March 2023 (09:02:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0155.v1

A New Interpretation of the Higgs Vacuum Potential Energy Based on a Planckion Composite Model for the Higgs

Christopher Pilot

Subject: Physical Sciences, Particle And Field Physics Keywords: Winterberg model; Planck particles; positive and negative mass Planck particles; planckions; quantum vacuum; space as a superfluid/ supersolid; extended models for space; cosmological constant; Higgs field as a composite particle; Higgs boson; inherent length scale for the vacuum; dark energy

Online: 8 March 2023 (10:17:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0434.v1

Identification of a NACC1-Regulated Gene Signature Impli-Cated in the Features of Triple-Negative Breast Cancer

Xia Liu, Chrispus Ngule, Hami Hemati, Oluwafunminiyi Obaleye, Amos Oyelami, Felix Oyelami, Xingcong Ren, Jianxun Song, Xiaofang Xiong, Jin-ming Yang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Tumor progression; cancer stem cells; gene signature; NACC1; triple negative breast cancer

Online: 27 February 2023 (03:10:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0089.v6

Omnidimensional Convex Polytopes

Szymon Łukaszyk, Andrzej Tomski

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular basic convex polytopes; circumscribed and inscribed polytopes; negative dimensions; fractal dimensions; complex dimensions; emergent dimensionality; mathematical physics

Online: 24 February 2023 (15:41:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0120.v1

Too Committed to Switch off – Capturing and Organizing the Full Range of Work-Related Rumination from Detachment to Overcommitment

Oliver Weigelt, J. Charlotte Seidel, Lucy Erber, Johannes Wendsche, Yasemin Z. Varol, Gerald M. Weiher, Petra Gierer, Claudia Sciannimanica, Richard Janzen, Christine J. Syrek

Subject: Social Sciences, Psychology Keywords: work-related rumination; overcommitment; psychological detachment; burnout; irritation; problem-solving pondering; positive work reflection; negative work reflection; affective rumination; satisfaction with life

Online: 6 January 2023 (09:36:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0703.v5

On the Fundamental Particles and Reactions of Nature

Jian-Bin Bao, Nicholas P. Bao

Subject: Physical Sciences, Quantum Science And Technology Keywords: aether; hypoatom; neutrino; inflation; gravity; negative pressure; dark energy; dark matter; black hole; spinning universe; quantum mechanics; first galaxies; spin-1/2 particle; matter-antimatter asymmetry; baryogenesis-through-leptogenesis; fabric of space; conformal cyclic cosmology; center of the universe; fate of the universe; general theory of relativity; parity non-conservation in weak interactions

Online: 4 January 2023 (02:26:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0450.v1

Klein-Gordon, Dirac and Schrodinger Equations, Matter and Wave Function Collapses, Photon Momenta and the Gamma Ray Burst based on the 4-D Euclidean Space

Jae-Kwang Hwang

Subject: Physical Sciences, Particle And Field Physics Keywords: P4 = TcP symmetry; Matter collapse; Wave function collapse; Klein paradox; Continuity equations; Negative energy solutions; Gamma ray burst; Photon momenta

Online: 23 December 2022 (07:57:12 CET)

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The negative energy solutions of the Klein-Gordon and Dirac equations have been used to define the antiparticle with the positive energy from the Feynman - Stueckelberg interpretation in the standard model based on the 4-D Minkowski space with the relative time. The negative energy solutions of the Klein-Gordon and Dirac equations are used to define the antiparticles with the negative energy in the present 3-D quantized space model. Note that all the present results are based on the 4-D Euclidean space with the absolute time (t) and relative time (t_l). Then the particle with the positive energy and antiparticle with the negative energy have the 4-D P₄ = TCP = T_cP symmetry. The continuity equations are derived from the Klein-Gordon, Dirac and Schrodinger equations. The Klein-Gordon and Schrodinger equations with the potential barriers are solved. The Klein paradox is explained by using the pair production of the electron with the positive energy and positron with the negative energy under the P₄ = _TcP symmetry, The effective velocity ( c_eff=√2 " c " ) and effective energy ("Etl =" √2 E ) along the relative time axis (ctl) give the relative time momentum of "p_tl"=E_tl/c_eff =(√2 E)/(√2 c)=E/c=p_t=p_x. This indicates that the photons with the energy of E have the constant photon velocity of c and the constant photon momentum of "ptl"=E_tl/c_eff =(√2 E)/(√2 c)=E/c=p_t=p_x. For the negative energy particles, the space momentum directions are opposite to the particle velocity directions because the energy is negative. And the matter collapse to the photons at the very high particle velocity is discussed from the length expansion. It is, for the first time, proposed that the gamma ray burst is originated from the matter collapse to the photons near the black hole. Also, the wave function collapse is explained from the length expansion. The wave function collapse takes place when the measurement makes the particle velocity to be zero. It is concluded that the negative energy solutions of the Klein-Gordon and Dirac equations support the existence of the partner antimatter universe with the negative energy and negative time direction. Our matter universe has the positive energy and the positive time direction.

Preprint ARTICLE | doi:10.20944/preprints202212.0399.v1

Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer

Emilio Guillén-Mancina, Julio José Jiménez-Alonso, José Manuel Calderón-Montaño, Víctor Jiménez-González, Patricia Díaz-Ortega, Estefanía Burgos-Morón, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Amino acids, lipids, diet, low-fat diet, cancer therapy, cancer metabolism, triple-negative breast cancer, lung cancer, melanoma, colorectal cancer, ovarian cancer, metastasis

Online: 21 December 2022 (10:05:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0178.v2

Bending Response and Energy Dissipation of Interlayered Slidable Friction Booklike-Plates

Bohua Sun, Wen Dang, Xuanting Liu, Xiao-Lin Guo

Subject: Physical Sciences, Applied Physics Keywords: Hardcover book; multilayer; plates; curvature; bending; friction; dissipation; deflection

Online: 14 December 2022 (06:19:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0462.v1

Diagnostic Significance of hsa-miR-21-5p, hsa-miR-192-5p, hsa-miR-155-5p, hsa-miR-199a-5p Panel and Ratios in Hepatocellular Carcinoma on top of Liver Cirrhosis in HCV Infected Patients

Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. AbdelHamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A Shaheen, Areej Rushdi, Reem M Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HCC; hsa-miR-21-5p; hsa-miR-155-5p; hsa-miR-192-5p; hsa-miR-199a-5p; liver cirrhosis; HCV; AFP-negative HCC

Online: 25 November 2022 (02:26:16 CET)

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Hepatocellular carcinoma (HCC) early diagnosis is challenging. Moreover, for patients with al-pha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profile may serve as potential HCC molecular markers. We aimed to assess plasma homo sabines (hsa)-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, hsa-miR-199a-5p expression levels, as panel of biomarkers for HCC in chronic hepatitis C virus (CHCV) patients with liver cirrhosis (LC), es-pecially AFP-negative HCC cases, a step toward non-protein coding (nc) RNA precision medicine. Subjects and Methods: 79 patients enrolled with CHCV infection with LC, subclassified into LC group without HCC (n=40) and LC with HCC (n=39) in comparison with 15 apparently healthy control subjects. Real-time quantitative PCR was used to measure plasma hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p. Results: Plasma hsa-miR-21-5p and hsa-miR-155-5p demonstrated significant upregulation, while hsa-miR-199a-5p demonstrated significant downregulation in the HCC group (n=39) when compared to LC group (n=40). Hsa-miR-21-5p expression was positively correlated with serum AFP, insulin, and insulin re-sistance (r=0.5, p<0.001, r=0.334, p=0.01, and r=0.303, p=0.02, respectively). According to the ROC curves, for differentiating HCC from LC, combining AFP with each of hsa-miR-21-5p, hsa-miR-155-5p, and miR199a-5p improved the diagnostic sensitivity to 87%, 82%, and 84%, re-spectively, vs 69% for AFP alone, with an acceptable specificity of 77.5%, 77.5%, and 80%, respec-tively, and AUC= 0.89, 0.85, and 0.90, respectively vs. 0.85 for AFP alone. Hsa-miR-21-5p/hsa-miR-199a-5p and hsa-miR-155-5p/hsa-miR-199a-5p ratios discriminated HCC from LC at AUC=0.76 and 0.71, respectively, with sensitivities=94% and 92%, and specifici-ties=48% and 53%, respectively. Upregulation of plasma hsa-miR-21-5p was considered as an independent risk factor for HCC development [OR=1.198(1.063–1.329), p=0.002]. Conclusion: Combining each of hsa-miR-21-5p, hsa-miR-155-5p, and hsa-miR-199a-5p with AFP made possi-ble to identify HCC development in LC patients’ cohort with higher sensitivity than using AFP alone. Hsa-miR-21-5p/hsa-miR-199a-5p and hsa-miR-155-5p/hsa-miR-199a-5p ratios are poten-tial HCC molecular markers for AFP-negative HCC patients. Hsa-miR-21-5p was linked to insu-lin metabolism in HCC patients’ group as well as being an upregulated independent risk factor for the emergence of HCC from LC in CHCV patients.

Preprint ARTICLE | doi:10.20944/preprints202211.0381.v1

Diversity and Safety Aspects of Coagulase Negative Staphylococci in Ventricina Del Vastese Italian Dry Fermented Sausage

Carmela Amadoro, Franca Rossi, Palmiro Poltronieri, Lucio Marino, Giampaolo Colavita

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: fermented sausage; Ventricina del Vastese; traditional production; coagulase negative staphylo-cocci; hazardous genetic traits; antibiotic resistance

Online: 21 November 2022 (07:31:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0296.v1

N10-C11 Imine is Essential for Gram-negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines

Pietro Picconi, Charlotte K. Hind, J. Mark Sutton, Khondaker Miraz Rahman

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: antimicrobial resistance; broad-spectrum antibiotics; antibacterial drug discovery; gram-negative bacteria; pyrrolobenzodiazepines

Online: 16 November 2022 (04:20:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0123.v5

A Unified Field Theory Derived from a Magnetic Confinement Method that Stimulates Curvature Upon Charged Particles Relative to a Solitary Location that Produces Energy from Particle Deviation

Samuel Moss

Subject: Physical Sciences, Quantum Science And Technology Keywords: fusion; tokamak; inertial electrostatic confinement; magnetic reconnection; quantum gravity; general relativity; unified field theory; relative acceleration; geodesic deviation; Riemann Curvature; Faraday; Maxwell; Einstien; Dark Matter; Dark Energy

Online: 17 October 2022 (11:43:06 CEST)

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This interdisciplinary work presents a novel patent pending method of inertial electrostatic confinement (IEC) fusion called the Nuclear Electromagnetic Shaping Accelerator Reactor (NESAR) that addresses all of the major failure problems with currently known methods of IEC fusion. A brief background of previous IEC methods that generate a negative potential well to accelerate ions for fusion will be reviewed and compared to the NESAR method of magnetic confinement. In addition, a direct comparison will be presented between the NESAR and the tokamak method of fusion. The NESAR method of fusion obtains the plasma oscillation and compression capabilities of a tokamak without producing the catastrophic magnetic reconnection disruptions that currently plague tokamaks. Since the NESAR can oscillate charged particles comparable to the tokamak, this work will briefly review the history of the tokamak, how sawtooth magnetic reconnection occurs, and how the NESAR precludes the occurrence of magnetic reconnection. This work will also review the beginnings of a novel theory that has obtained interest from the Defense Advanced Research Projects Agency (DARPA) which is currently interested in possibly supporting further research into the NESAR to explore this new theoretical concept. This novel theory is a unified field theory based upon the trajectory of charged particle movements within the NESAR. The NESAR is the only concept of magnetic confinement in the world that may have the capability to allow charge particles to collectively interact relatively to a solitary location. Due to this possible capability, there is a probability that the confined particles may experience curved trajectories that could allow them to experience the effects of curvature deviation. If curvature deviation occurs with these magnetically confined charged particles; then the deviated acceleration would allow for the electromagnet field to be propelled to a higher dimension that could influence spacetime. Finally, this work will review another theory that explains how pole reversals are observed by the National Aeronautics and Space Administration’s (NASA) coiled magnetic field detectors. This theory requires little to no postulations to be framed and it is purely based upon the trajectory of charged particles within the NESAR, Michael Faraday’s law of induction, and experimental observations of rotating plasmas.

Preprint ARTICLE | doi:10.20944/preprints202101.0501.v3

An Exact Solution to the Free Vibration Analysis of a Uniform Timoshenko Beam Using a Moment-Shear Force-Circular Frequency-Curvature Relationship

Valentin Fogang

Subject: Physical Sciences, Applied Physics Keywords: Timoshenko beam; rotary inertia; moment shear force circular frequency curvature relationship; spring mass system; closed-form solutions; first-order dynamic stiffness matrix; second-order vibration analysis

Online: 7 October 2022 (10:34:31 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202209.0379.v1

Drone Delivery of Dehydro-Sulfurization Utilizing Doubly-Charged Negative Ions of Nanoscale Catalysts Inspired by the Biomimicry of Bee Species’ Bio-Catalysis of Pollen Conversion to Organic Honey

Kelvin L. Suggs, Duminda K. Samarakoon, Alfred Msezane

Subject: Chemistry And Materials Science, Other Keywords: fullerene; graphene; molybdenum disulfide; carbon nanotubes; catalysts; density functional theory; enzymes; honeybee biomimicry; drones; depollution; doubly-charged negative ions

Online: 26 September 2022 (05:40:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0251.v1

Applicability of Asymmetric Specimens for Residual Stress Evaluation in Fiber Metal Laminates

Johannes Wiedemann, Jan-Uwe R. Schmidt, Christian Hühne

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: fiber metal laminate; hybrid laminate; residual stress; asymmetric laminate; process monitoring; curvature analysis; stress-free temperature

Online: 19 September 2022 (02:03:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0133.v1

Can Radiomics Provide Additional Information in [18F]FET-Negative Glioma?

Katharina Von Rohr, Marcus Unterrainer, Adrien Holzgreve, Maximilian A. Kirchner, Zhicong Li, Lena M. Unterrainer, Bogdana Suchorska, Matthias Brendel, Jörg-Christian Tonn, Peter Bartenstein, Sibylle Ziegler, Nathalie L. Albert, Lena Kaiser

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: amino acid PET; FET PET; glioma; FET negative; photopenic; radiomics

Online: 9 September 2022 (09:31:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0511.v1

Phytochemical Composition and Antibacterial Activity of Zingiber cassumunar Roxb. against Agricultural and Foodborne Pathogens

Maha A. Alshiekheid, Yheni Dwiningsih, Amal Abdullah Sabour, Jawaher Alkahtani

Subject: Biology And Life Sciences, Plant Sciences Keywords: Zingiber cassumunar Roxb.; essential oils; microencapsulated products; antibacterial activity; agricultural pathogens; foodborne pathogens; gram-positive bacteria; gram-negative bacteria

Online: 30 August 2022 (07:02:54 CEST)

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Zingiber cassumunar Roxb. is a powerful medicinal plant that has been used as traditional medicine to cure respiratory problems, pain, and inflammation in China, Indonesia, Thailand and other Asian countries by using the crude extracts. The objective of this research is to identify phytochemical composition of Z. cassumunar Roxb. and to analyze antibacterial activity of crude extract, purified compounds, and their microencapsulated products of Rhizome Z. cassumunar Roxb. Identification of phytochemical composition in crude extract of rhizome Z. cassumunar Roxb. was achieved by chromatography-mass spectrophotometer. The major phytochemical composition in crude extract of Z. cassumunar Roxb. is essential oils, including terpinen4-ol (37.7%), β-pinene (20.8%), and (E)-1-(3,4-dimethoxyphenyl)but-1-ene (13.3%). Crude extract of Z. cassumunar Roxb. was purified with silica gel flash column chromatography, resulting two purified compounds. The antibacterial activity of crude extract, purified compounds, and their microencapsulated products of Rhizome Z. cassumunar Roxb. were evaluated against agricultural and foodborne pathogens by using disc agar diffusion and broth microdilution techniques. All of the samples studied (crude extracts, purified compounds, and microencapsulated of Z. cassumunar Roxb.) were effective against all the bacteria. Based on the results of the disc-diffusion assay suggested that amongst the samples studied, purified compounds (compound 1 and 2) and microencapsulated purified compounds (compound 1 and 2) exhibited more effective against all the bacteria compared to the crude extracts. Antibacterial activity of the rhizome of Z. cassumunar Roxb. was contributed mainly by the essential oils components as the active compounds. Gram-negative bacteria (X. oryzae, X. translucens, Pseudomonas spp, E. coli, and S. typhimurium) appeared to the most resistant to the crude extracts, purified compounds, and microencapsulated of Z. cassumunar Roxb. compared to the gram-positive bacteria (S. aureus, B. cereus, and L. monocytogenes). Microencapsulated of the tested samples (crude extract, purified compound 1, and purified compound 2) of the rhizome Z. cassumunar Roxb. exhibited high antibacterial activity with no significantly different with the tested samples without microencapsulation. These results suggest potential antibacterial properties of Z. cassumunar Roxb., which useful for agricultural plant health, food preservation, natural therapies, and pharmaceuticals.

Preprint ARTICLE | doi:10.20944/preprints202208.0433.v1

Spiropyran/Merocyanine Amphiphile in Various Solvents: A Joint Experimental–Theoretical Approach to Photophysical Properties and Self-Assembly

Vladyslav Savchenko, Nino Lomadze, Svetlana Santer, Olga Guskova

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: spiropyran/merocyanine isomerization; negative photochromism; time-resolved UV-vis measurements; molecular modeling

Online: 25 August 2022 (10:22:35 CEST)

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This joint experimental-theoretical work focuses on molecular and photophysical properties of the spiropyran-containing amphiphilic molecule in organic and aqueous solutions. Being dissolved in tested organic solvents, the system demonstrates positive photochromism, i.e. upon UV stimulus the colorless spiropyran form is transformed into colorful merocyanine isomer. However, aqueous solution of the amphiphile possesses a negative photochromism: the orange-red merocyanine form turns to be thermodynamically more stable in water, and both UV and vis stimuli lead to the partial or complete photobleaching of the solution. The explanation of this phenomenon is given on the basis of density functional theory calculations and classical modeling including thermodynamic integration. The simulations reveal that stabilization of merocyanine in water proceeds with the energy of ca. 70 kJ mol−1, and that the Helmholtz free energy of hydration of merocyanine form is 100 kJ mol−1 lower as compared to the behavior of SP isomer in water. The explanation of such a difference lies in the molecular properties of the merocyanine: after ring-opening reaction this molecule transforms into a zwitterionic form, as evidenced by the electrostatic potential plotted around the opened form. The presence of three charged groups on the periphery of a flat conjugated backbone stimulates the self-assembly of merocyanine molecules in water, ending up with the formation of elongated associates with stack-like building blocks, as shown in molecular dynamics simulations of the aqueous solution with the concentration above critical micelle concentration. Our quantitative evaluation of the hydrophilicity switching in spiropyran/merocyanine containing surfactants may prompt the search for new systems, including colloidal and polymeric ones, aiming at remote tuning of their morphology, which could give new promising shapes and patterns for the needs of modern nanotechnology.

Preprint REVIEW | doi:10.20944/preprints202208.0419.v1

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Keerthana Sureshkumar, Julian Guo, Michelle Tran, Sagunya Malhotra, Syed M Ahmad, Kabirullah Lutfy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alcohol; Dynorphin; Kappa Opioid Receptor; DYN/KOR; Anxiety; Depression; Negative Affective States; Withdrawal; Microdialysis; Dynorphin-immunoreactivity

Online: 24 August 2022 (10:52:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0366.v1

A Review of Mechanics-Based Mesoscopic Membrane Remodelling Methods: Capturing Both the Physics and the Chemical Diversity

Gaurav Kumar, Satya Chaithanya Duggisetty, Anand Srivastava

Subject: Physical Sciences, Biophysics Keywords: Curvature proteins; Membrane Remodelling; Protein-protein interactions; Mesoscopic Modeling; Backmapping and molecular reconstruction

Online: 22 August 2022 (03:20:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0129.v1

A Study of the Jacobi Stability of the Rosenzweig–MacArthur Predator–prey System by the KCC Geometric Theory

Florian Munteanu

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: predator–prey systems; Kolmogorov systems; KCC-theory; the deviation curvature tensor; Jacobi stability

Online: 8 August 2022 (03:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0028.v1

Depolarizing Effects in Hydrogen Bond Energy in 3₁₀-Helices Revealed by Quantum Chemical Analysis

Hiroko X. Kondo, Haruki Nakamura, Yu Takano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: 310-helix; hydrogen bond energy; density functional theory; negative fragmentation analysis

Online: 2 August 2022 (03:15:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0409.v1

MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans

Clayton Yates, Anusha Angajala, Aliyu Muhammad, Hughley Raymond, Shakir Md Ahmed, Saadia Haleema, Monira Haque, Honghe Wang, Rachel Martini, Balasubramanian Karanam, Andrea G. Kahn, Deepa Bedi, Melissa Davis, Ming Tan, Windy Dean-Colomb

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: QNBC (Quadruple negative breast cancer); AR (Androgen receptor); AA (African American); CA (Caucasian); BC (Breast cancer)

Online: 27 July 2022 (04:07:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0108.v1

Molecular Dynamics Simulations of Curved Lipid Membranes

Andreas Haahr Larsen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: membrane curvature; molecular dynamics; simulations; BAR domain; trafficking

Online: 7 July 2022 (04:19:42 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202207.0008.v1

Dehydro-Sulfurization Utilizing Doubly-Charged Negative Ions of Molybdenum Disulfide (MoS2), Graphene-Flake (GR-28), Armchair Carbon Nanotube (CNT 6,6), and Fullerene (C-60) as Catalysts for Depollution, Natural Resource Mining, and the Chemical Functiona

Kelvin L Suggs, Duminda K Samarakoon, Alfred Msezane

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: fullerene, graphene, molybdenum disulfide, carbon nanotubes, catalysts, density functional theory, enzymes, honeybee biomimicry, drones, depollution, doubly-charged negative ions

Online: 1 July 2022 (08:12:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0263.v9

Novel Recurrence Relations for Volumes and Surfaces of N-Balls, Regular N-Simplices, and N-Orthoplices in Real Dimensions

Szymon Łukaszyk

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular convex polytopes; negative dimensions; fractal dimensions

Online: 8 June 2022 (12:29:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0233.v1

Social Robots Outdo the Not-so-Social Media for Self-disclosure: Safe Machines Preferred to Unsafe Humans?

Rowling Luo, Thea Zhang, Derrick Chen, Johan F. Hoorn, Ivy Huang

Subject: Business, Economics And Management, Accounting And Taxation Keywords: social media; social robots; negative mood; self-disclosure; intervention design; anthropomorphic design

Online: 16 June 2022 (06:11:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0326.v1

Buckling Behavior of Different Types of Woven Structures Under Axial Compression Loads

Guangkai Song, Bohua Sun

Subject: Engineering, Mechanical Engineering Keywords: In-plane curvatures; Buckling; Woven structure; 3D print; Gaussian curvature

Online: 24 May 2022 (09:06:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0262.v1

Clamping Force of A Multilayered Cylindrical Clamp with Internal Friction

Bohua Sun, Xiao-Lin Guo

Subject: Physical Sciences, Applied Physics Keywords: Clamping force; multilayer clamp; curvature; bending; friction; dissipation; deflection

Online: 27 April 2022 (11:35:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0198.v1

"Gravitationally Lensed Gravity" from a Spacetime Perspective

Andreas Boenke

Subject: Physical Sciences, Theoretical Physics Keywords: gravity; gravitational lens; gravitationally lensed gravity; GLG; general relativity; spacetime curvature; light cone; null cone; gravity null cone; null geodesic; speed of gravity; Newtonian Limit; Minkowski diagram

Online: 21 April 2022 (09:19:44 CEST)

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A gravitational lens is mass-curved spacetime. Light that propagates freely, locally always on the fastest way, follows curved paths in it. The same applies to all effects propagating with the speed of light, also to gravity itself. They all have to follow the curvature of spacetime. A gravitational lens not only enhances the light from background objects but concurrently also their gravitational effect ! The "Gravitationally Lensed Gravity" (GLG) is a still scarcely noticed peculiar feature of general relativity. In [1] I presented a thought experiment to make the existence of this effect plausible. Here these considerations are described in terms of future and past light cones or null cones commonly used in relativity theory to illustrate the causal structure of spacetime. In the framework of general relativity, the GLG effect can be understood as a consequence of the folding of the past null cone by a gravitational lens. Starting from the basic ideas of the theory, the terms are introduced and applied. The extensive description on textbook level should be understandable also for beginners. In order not to obstruct the view on the essential physical relations, I avoid a mathematical formalism and use instead diagrams and figures, based on realistic numerical calculations, to reinforce my logical argumentation. Experts will recognize many long-known facts, but may still be surprised by the resulting conclusions. First, I present some particular aspects of the historical evolution of the concept of gravitational lensing and give a brief overview of the work of other authors on the subject GLG. I then explain the limitations of the applicability of the "Newtonian Limit" and move on to the key role of the speed of gravity in understanding GLG. Finally, I use a simple example to illustrate the possible significance of the GLG effect. With this work I intend to elicit greater interest in "Gravitationally Lensed Gravity" and to initiate a broader discussion about it.

Preprint ARTICLE | doi:10.20944/preprints202204.0080.v1

The Effect of Negative Mass in Gravitating System

Edward Bormashenko

Subject: Physical Sciences, Applied Physics Keywords: core-spring-shell system; gravitating system; negative mass; Coulomb-like forces

Online: 8 April 2022 (11:12:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0357.v1

Negative Electrical Conductivity Metamaterials

Edward Bormashenko

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: metamaterial; negative electrical conductivity; negative mass; Drude-Lorentz model; negative refraction

Online: 28 March 2022 (08:56:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0297.v1

The Effect of Intratumoral Interrelation among FOXP3+ Regulatory T cells on Treatment Response and Survival in Triple-Negative Breast Cancer

Noriko Goda, Chika Nakashima, Ichiro Nagamine, Sunao Otagaki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: regulatory T cell; tumor-infiltrating lymphocyte; neoadjuvant chemotherapy; triple-negative breast cancer

Online: 22 March 2022 (07:50:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0133.v1

Phenotypic Heterogeneity Drives Differential Disease Outcome in Triple Negative Breast Cancer

Archana P. Thankamony, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Radhika Nair

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Intratumoral heterogeneity; Triple negative breast cancer (TNBC); Macc1; Phenotypic heteroge-neity

Online: 9 February 2022 (10:40:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0112.v1

Auxetic Structures from Rotating Squares

Julian Plewa, Małgorzata Płońska, Paweł Lis

Subject: Engineering, Mechanical Engineering Keywords: auxetic structures; metamaterials; negative Poisson’s ratio (NPR)

Online: 8 February 2022 (13:15:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0026.v1

Dark Energy is Dark Matter below Absolute Zero in Black Holes

Roumen Tsekov

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Neutrino, Dark Matter, Dark Energy, Black Holes, Negative Temperature

Online: 2 February 2022 (09:35:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0409.v1

Nonlinear Investigation of Gol'denveizer's Problem of a Circular and Elliptic Elastic Torus

Guangkai Song, Bohua Sun

Subject: Engineering, Mechanical Engineering Keywords: circular torus; elliptic torus; finite element method; buckling; nonlinear analysis; Gaussian curvature

Online: 27 January 2022 (06:58:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0326.v2

Displacement Formulations for Deformation and Vibration of Elastic Circular Torus

Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: circular torus; deformation; vibration; Gauss curvature; Maple

Online: 25 January 2022 (10:04:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0349.v1

Spatial Distribution of Cyclograpsus cinereus Dana 1851 in Rocky Shores of Antofagasta (23º27’ S, Chile)

Patricio De los Rios-Escalante, Carlos Esse, Marco Antonio Retamal, Oscar Zuñiga, Maritza Fajardo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Cyclograpsus cinereus; spatial distribution; intertidal; rocky shore; negative binomial distribution.

Online: 24 January 2022 (11:48:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0230.v1

Refusal Parenting Style Is Easier for Students to Perceive Non-physical Bullying in the Upper Grades of Elementary School: Mediation Effect of Negative Affect Experience and Negative Coping Style

Houyu Zhou, Qinfei Wang, Shuxu Yu, Quangquang Zheng

Subject: Social Sciences, Psychology Keywords: perceiving campus non-physical bullying; Refusal parenting style; negative affect experiences; negative coping style; mediating effect

Online: 17 January 2022 (14:09:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0100.v1

Audoly-Pomeau Linear Law of the Gol'denveizer Torus

Guangkai Song, Bohua Sun

Subject: Engineering, Mechanical Engineering Keywords: circular torus; finite element method; analytical solution; Gaussian curvature

Online: 10 January 2022 (11:27:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0476.v1

Comparison of social inequality in HPV vaccination among teenagers with parental reports and healthcare providers’ records in the 2019 National Immunization Survey-Teen.

Sol Seo Choi, Bongkyoo Choi

Subject: Social Sciences, Sociology Keywords: Human Papillomavirus, vaccine, social inequality, NIS-Teen, false negative, SES.

Online: 30 December 2021 (00:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0270.v2

Improve the Three-phase Unbalance Rate of Railway System Under 2% By Three Kinds of Special Transformer Wiring

Chien-Hsu Chen, Chin E. Lin

Subject: Engineering, Electrical And Electronic Engineering Keywords: three-phase unbalance rate (TPUR); negative phase sequence unbalance rate (NPSUR); special transformer wiring (STW); Railway System Transport Cable (RSTC); Traction Supply Substation (TSS)

Online: 14 December 2021 (15:26:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0087.v1

Numerical Deformation Analysis of Reinforced Lightweight Aggregate Concrete Flexural Members

Darius Bacinskas, Deividas Rumsys, Gintaris Kaklauskas

Subject: Engineering, Civil Engineering Keywords: lightweight aggregate concrete; reinforced concrete; slab; bridge girder; curvature; short-term loading; tension stiffening; constitutive model; numerical modelling.

Online: 6 December 2021 (15:33:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0349.v3

Geometry-Induced Rigidity in Elastic Torus from Circular to Oblique Elliptic Cross-Section

Bohua Sun

Subject: Physical Sciences, Applied Physics Keywords: elliptic torus; oblique; nonlinear deformation; vibration; Gauss curvature; Maple

Online: 25 November 2021 (11:21:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0042.v1

Modulation Instability of Hydro-Elastic Waves Blown by a Wind with a Uniform Vertical Profile

S. Boral, T. Sahoo, Y. Stepanyants

Subject: Physical Sciences, Mathematical Physics Keywords: Wind wave; Ice cover; Vortex sheet; Negative energy wave; Modulation instability

Online: 2 November 2021 (10:53:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0018.v1

The Immunomodulatory Activity in vitro of NDV ZG1999HDS in Comparison to NDV La Sota

Bratko Filipič, Lidija Gradišnik, Adriana Pereyra, Hrvoje Mazija

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Newcastle Disease Virus (NDV); NDV ZG1999HDS; NDV La Sota; TLT (Human macrophage cell line; Immunomodulation; Anti - Gram Positive bacteria; Anti - Gram - Negative bacteria; activity

Online: 1 November 2021 (13:01:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0076.v6

Unification of the Electromagnetic Force and Gravity through the Composite Photon

Ian Clague

Subject: Physical Sciences, Acoustics Keywords: Unification; Composite Photon; Negative Mass; Antimatter; Grand Unification Theory, Dark Energy, Dark Matter

Online: 28 October 2021 (10:06:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0255.v1

Exact Solutions for a Novel H₂ Optimal Design of Electromagnetic Tuned Mass Damper

Ge Li, Qibo Mao, Yifan Luo, Yong Wang, Lei Liu

Subject: Engineering, Mechanical Engineering Keywords: electromagnetic tuned mass damper; H2 optimization; structural vibration control; negative inductance; negative resistance.

Online: 18 October 2021 (15:37:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0318.v1

From Maximal Force to the Field Equations of General Relativity

C Sivaram, Arun Kenath, Christoph Schiller

Subject: Physical Sciences, Space Science Keywords: General relativity, Maximal force, Maximal power, Cosmological constant, Planck curvature

Online: 17 September 2021 (15:07:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0085.v1

Chick Embryo Experimental Platform for 3D Tissue Engineering Modelling of Cancer Micrometastases for Tumor Biology, Drug Development and Nanomaterials Testing

Anna Guller, Inga Kuschnerus, Vlada Rozova, Annemarie Nadort, Yin Yao, Zahra Khabir, Alfonso Garcia-Bennett, Liuen (Olivia) Liang, Aleksandra Polikarpova, Yi Qian, Ewa M. Goldys, Andrei Zvyagin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chick embryo; 3D culture; tumor models in vitro; tissue engineering; metastasis; triple-negative breast cancer; liver; mesoporous silica nanoparticles; doxorubicin; micrometastasis

Online: 6 September 2021 (11:46:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0083.v1

Is the Higgs Field a Positive and Negative Mass Planckion Condensate, and Does the LHC Produce Extreme Dark Energy?

Christopher Pilot

Subject: Physical Sciences, Particle And Field Physics Keywords: Winterberg Model; Quantum Vacuum; Higgs Condensate/Composite Model; Two-Component Superfluid/Supersolid Model for the Vacuum; Positive/Negative Planckion Mass, Q-Theory; Non- Linear Heisenberg Spinor Theory; LHC Energies, Dark Energy; Lattice Substructure for Space

Online: 6 September 2021 (10:38:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0486.v1

The Modified Fundamental Equations of Quantum Mechanics in Symmetric Forms

Huai-Yu Wang

Subject: Physical Sciences, Quantum Science And Technology Keywords: Dirac equation; Klein-Gordon equation; Schrödinger equation; negative kinetic energy; Decoupled Klein-Gordon equation; negative kinetic energy Schrödinger equation

Online: 25 August 2021 (10:50:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0626.v1

A High Efficacy DNA Vaccine Against Tilapia Lake Virus in Nile Tilapia (Oreochromis niloticus)

Nai-tong Yu, Wei-wei Zeng, Jian-hua Wang, Yu-liang Zhang, Xiu-chun Zhang, Zhi-xin Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tilapia; negative-sense RNA virus; Tilapia lake virus; DNA vaccine

Online: 28 July 2021 (11:11:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0614.v1

Mixed Effects and Mechanisms of Cannabinoids for Triple-Negative Breast Cancer Treatment

Khanh Tran

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Triple-negative breast cancer; cannabinoid; marijuana; cell signalling; medicinal plants

Online: 28 July 2021 (08:56:32 CEST)

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Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the lack of estrogen receptors (ER), progesterone receptors, and HER-2 receptors. Thus, TNBC tumours do not benefit from the current therapies targeting ER or HER-2. Therefore, there is an urgent need to develop novel treatment for this subtype of breast cancer. Marijuana is a common name given to Cannabis plants, a group of plants in the Cannabis genus of the Cannabaceae family. Cannabis plants are among the oldest cultivated crops, traced back at least 12,000 years and are well known for their multi-purpose usage, including medicinal purposes. The main active compounds extracted from Cannabis plants are 21-carbon-containing terpenophenolics, which are referred to as phytocannabinoids. Of these, the tetrahydrocannabinol (THC) group contains highly potent cannabinoids, including delta-9-tetrahydrocannabinol (∆9-THC) and delta-8-tetrahydrocannabinol (∆8-THC), which are the most abundant THCs and are largely responsible for psychological and physiological effects of marijuana. The use of Cannabis plants for medicinal purposes was first recorded in 2337 BC in China, where Cannabis plants were used to treat pains, rheumatism, and gout. Recently, several cannabinoids have been approved for a number of treatments, one of which is the treatment of nausea and vomiting caused by chemotherapy in cancer patients. Furthermore, increasing evidence shows that cannabinoids not only attenuate side effects due to cancer treatment, but might also potentially possess direct antitumor effects in several cancer types, including breast cancer. However, anti-tumour activity of marijuana has been variable in different studies and even promoted tumour growth in some cases. In addition, the mechanisms of cannabinoid action in cancer remain unclear. This review summarizes evidence about the mixed actions of cannabinoids in cancer in general and triple-negative breast cancer in particular.

Preprint ARTICLE | doi:10.20944/preprints202107.0371.v1

Nonlinear Elastic Deformation of Mindlin Torus

Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: circular torus; nonlinear deformation; shear deformation; Mindlin; Gauss curvature; Maple

Online: 16 July 2021 (12:47:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0457.v3

Timoshenko Beam Theory: Exact Solution for First-Order Analysis, Second-Order Analysis, and Stability Using a Moment-Shear Force-Curvature Relationship

Valentin Fogang

Subject: Engineering, Automotive Engineering Keywords: Timoshenko beam; moment shear force curvature relationship; closed-form solutions; non-uniform heating; stability; second-order element stiffness matrix; elastic Winkler foundation

Online: 15 July 2021 (10:30:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0238.v1

An Idea about Negative Cosmic Time in the Big Bang-Big Rip Cosmological Model

Mohamed Abdalla Bakry, Ali Eid, A. Alkaoud

Subject: Physical Sciences, Acoustics Keywords: Negative cosmic time; cosmological solutions; variable deceleration parameter; big rip

Online: 12 July 2021 (09:46:04 CEST)

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Working Paper ARTICLE

Prognostic Impact of Immunoglobulin Kappa C (IGKC) In Early Breast Cancer

Marcus Schmidt, Karolina Edlund, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, Marco J. Battista, Walburgis Brenner, Annette Hasenburg, Jörg Rahnenführer, Mathias Gehrmann, Pirkko-Liisa Kellokumpu-Lehtinen, Ralph M Wirtz, Heikki Joensuu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: triple-negative breast cancer; prognosis; immune system; immunoglobulin kappa C

Online: 31 May 2021 (12:27:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0546.v1

Atezolizumab and Pembrolizumab in Triple-Negative Breast Cancer: A Meta-Analysis

Mahwish Amin, Shaiza Sharif, Waleed Asghar, Humaira Sadaf, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs

Online: 24 May 2021 (09:23:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0195.v1

Comparative Study of Computational Models for Reducing Air Pollution Through the Generation of Negative Ions

Paola Ortiz-Grisales, Julián Patiño-Murillo, Eduardo Duque-Grisales

Subject: Engineering, Automotive Engineering Keywords: Environmental pollution; air purification; negative ion generators; particulate matter.

Online: 10 May 2021 (14:02:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0782.v2

A Review of Electrospun Carbon Nanofiber-Based Negative Electrode Materials for Supercapacitors

Arjun Prasad Tiwari, Tanka Mukhiya, Alagan Muthurasu, Kisan Chhetri, Minju Lee, Bipeen Dahal, Prakash Chandra Lohani, Hak Yong Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: electrospinning; negative electrode materials; carbon nanofibers; free-standing; supercapacitor

Online: 10 May 2021 (09:34:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0688.v1

Direct Quantitation of SARS-CoV-2 Using Droplet Digital PCR in Suspected Samples With Very Low Viral Load

Michela Deiana, Chiara Piubelli, Antonio Mori, Gian Paolo Chiecchi, Giulia La Marca, Martina Leonardi, Davide Treggiari, Anna Beltrame, Lucia Moro, Zeno Bisoffi, Elena Pomari

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: droplet digital PCR; real time RT-PCR; SARS-CoV-2; false negative; viral load; diagnosis

Online: 26 April 2021 (20:09:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0494.v1

Deformation and Stress Analysis of Catenary Shell of Revolution

Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: Catenary; surface of revolution; Gauss curvature; minimal surface; shells; deformation; stress; Maple

Online: 19 April 2021 (14:03:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202012.0420.v3

Small Symmetrical Deformation of Thin Torus with Circular Cross-Section

Bohua Sun

Subject: Computer Science And Mathematics, Mathematics Keywords: toroidal shell; deformation; Gauss curvature; Heun function; hypergeometric function; Maple

Online: 19 April 2021 (12:03:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0433.v1

SRT as a Fourth-order-theory with Analogy-model of Damped Resonance

Holger Döring

Subject: Physical Sciences, Acoustics Keywords: SRT; fourth-order-theory; any velocity; FTL; real rest mass; resonance analogy; damped space-time; SR-Extrapolation; superluminal-velocity; negative kinetic energy; fourth-order worldline-element; no-tachyons

Online: 16 April 2021 (10:42:35 CEST)

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Working Paper ARTICLE

Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer

Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader El-Sayes, Karen Mossman, John Valliant

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; immunotherapy; immune checkpoint therapy; radionuclide therapy

Online: 9 April 2021 (13:26:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0777.v1

Prediction of Response to Atezolizumab Plus Nab-Paclitaxel in Unresectable Locally Advanced Triple Negative Breast Cancer (TNBC): the ClinicalUsefulness of PD-L1 mRNA Expression in Plasma-Derived Exosomes

Lucrezia Raimondi, Gian Paolo Spinelli, Paolo Ciracì, Filippo Maria Raimondi, Rachele Lazzeroni, Laura Di Benedetto, Stefano Valabrega, Laura Giaconi, Luigi Rossi, Giuseppe Naso

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Exosomal PD-L1 mRNA; extracellular vesicles; Triple Negative Breast Cancer; Immunotherapy; PD-L1 axis; Atezolizumab – nab-paclitaxel; Predictive biomarkers; Liquid biopsy

Online: 31 March 2021 (15:27:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0201.v2

Detecting the Coronavirus (COVID-19)

Pravin Pokhrel, Changpeng Hu, Hanbin Mao

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2 Detection, SARS-CoV-2 Antibody Test, SARS-CoV-2 Antigen Test, False Negative, False Positive, Sensitivity, Specificity, Point-of-care testing (POCT), SARS-CoV-2 Mutants

Online: 25 March 2021 (15:33:14 CET)

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The COVID-19 pandemic has created huge damage to society and brought panics around the world. Such panics can be ascribed to the seemingly deceptive features of the COVID-19: compared to other deadly viral outspreads, it has medium transmission and mortality rates. As a result, the severity of the causative coronavirus, SARS-CoV-2, was deeply underestimated by the society at the beginning of the COVID-19 outbreak. Based on this, in this review, we define the viruses with features similar to those of SARS-CoV-2 as the Panic Zone viruses. To contain those viruses, accurate and fast diagnosis followed by effective isolation and treatment of patients are pivotal at the early stage of virus breakouts. This is especially true when there is no cure or vaccine available for a transmissible disease, which is the case for current COVID-19 pandemic. As of January 2021, more than two hundred kits for the COVID-19 diagnosis on the market are surveyed in this review, while emerging sensing techniques for SARS-CoV-2 are also discussed. It is of critical importance to rationally use these kits for the efficient management and control of the Panic Zone viruses. Therefore, we discuss guidelines to select diagnostic kits at different outbreak stages of the Panic Zone viruses, SARS-CoV-2 in particular. While it is of utmost importance to use nucleic acid-based detection kits with low false negativity (high sensitivity) at the early stage of an outbreak, the low false positivity (high specificity) gains its importance at later stages of the outbreak. When a society is set to reopen from the lock-down stage of the COVID-19 pandemic, it becomes critical to have antibody based immunoassay kits with high specificity to identify people who can safely return to the society after their recovery of SARS-CoV-2 infections. Given that the emergence of mutant viruses at the beginning of 2021 has complicated current battle against the COVID-19, we also discussed approaches and guidelines to detect viral mutants in the middle of the second wave of the pandemic that started at the end of 2020. Finally, since a massive attack from a viral pandemic requires a massive defense from the whole society, we urge both government and private sectors to research and develop more affordable and reliable point-of-care testing (POCT) kits, which can be used massively by the general public (and therefore called as massive POCT) to contain Panic Zone viruses in future.

Preprint ARTICLE | doi:10.20944/preprints202103.0570.v1

A Stochastic Condensation Mechanism for Inducing Underdispersion in Count Models

Chenangnon Frédéric Tovissodé, Romain Glele Kakai

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Erlang process; condensed distribution; probability generating function; algebraic moments; Poisson remainder distribution; negative binomial remainder distribution

Online: 23 March 2021 (12:57:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0521.v1

Modulation Instability of Surface Waves in the Model with the Uniform Wind Profile

Susam Boral, Trilochan Sahoo, Yury Stepanyants

Subject: Physical Sciences, Acoustics Keywords: Two-layer fluid; shear flow; air-water interface; surface tension; vortex sheet; Kelvin-Helmholtz instability; negative-energy wave; modulation instability

Online: 22 March 2021 (11:26:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0311.v1

Spaghetti Breaking Dynamics

Yi Zhang, Xiang Li, Yuanfan Dai, Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: curvature; brittle cracking; elastic rod; diameter-to-length ratio; spaghetti

Online: 11 March 2021 (11:00:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0304.v1

Gol'denveizer Problem of Elastic Torus

Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: torus; elastic; deformation; symmetric; Gauss curvature

Online: 11 March 2021 (10:16:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0300.v1

Deformation and Vibration of an Oblique Elliptic Torus

Bohua Sun

Subject: Physical Sciences, Acoustics Keywords: elliptic torus; oblique; deformation; vibration; Gauss curvature; Maple

Online: 11 March 2021 (08:39:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0078.v1

How Would Different Types of Negative Life Events Predict Adolescents’ Suicidal Ideation ? - an Empirical Study Based on the Western Region of China

Moye Xin, Xueyan Yang, Kun Liu

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Negative life events; Suicidal ideation; Suicidalogy; Adolescents; Gender difference

Online: 4 March 2021 (15:56:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0094.v3

“Clinician’s Probability Calculator” to Convert Pre-Test to Post-Test Probability of COVID-19, Based on Method Validation from Each Laboratory

Zoe Brooks, Saswati Das, Tom Pliura

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-COV-2; False-Positive; False-Negative; Likelihood Ratio; Probability; Calculator; Interpretation

Online: 3 March 2021 (10:08:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0055.v1

Semi-Covariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and other Coronaviruses for Viral Evolution and Characteristics Associated with Fatality

Jun Huang, Rebecca Spencer, Wangdong Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Fractional complex moment; SARS-CoV-2; coronaviruses; spike protein sequence; Pearson correlation coefficient; semi-covariance coefficient; positive-correlative and negative-correlative domains

Online: 2 March 2021 (09:30:12 CET)

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Complex modeling has received significant attention in recent years and is increasingly used to explain the statistical phenomenon with increasing and decreasing fluctuations such as the similarity or difference of spike protein charge patterns of coronaviruses. Different from the existing covariance or correlation coefficient methods in traditional integer dimension construction, this study proposes a simplified novel fractional dimension derivation with the exact Excel tool algorithm. It involves the fractional center moment extension to covariance, which ends up a complex covariance coefficient that is better than the Pearson correlation coefficient, in the sense that the nonlinearity relationship can be further depicted. The spike protein sequences of coronaviruses were obtained from the GenBank and GISAID database, including the coronaviruses from pangolin, bat, canine, swine (three variants), feline, tiger, SARS-CoV-1, MERS, and SARS-CoV-2 (including the strains of Wuhan, Beijing, New York, German, and UK variant B.1.1.7) were used as the representative examples in this study. By examining the values above and below the average/mean based on the positive and negative charge patterns of the amino acid residues of the spike proteins from coronaviruses, the proposed algorithm provides deep insights into the nonlinear evolving trends of spike proteins for understanding the viral evolution and identifying the protein characteristics associated with viral fatality. The calculation results demonstrate that the complex covariance coefficient analyzed by this algorithm is capable of distinguishing the subtle nonlinear differences in the spike protein charge patterns with reference to Wuhan strain SARS-CoV-2 for which the Pearson correlation coefficient may overlook. Our analysis reveals the unique convergent (positive correlative) to divergent (negative correlative) domain center positions of each virus. The convergent or conserved region may be critical to the viral stability or viability; while the divergent region is highly variable between coronaviruses suggesting high frequency of mutations in this region. The analyses show that the conserved center region of SARS-CoV-1 spike protein is located at amino acid residues 900, but shifted to the amino acid residues 700 in MERS spike protein, and then to amino acid residues 600 in SARS-COV-2 spike protein, indicating the evolvement of the coronaviruses. Interestingly, the conserved center region of the spike protein in SARS-COV-2 variant B.1.1.7 shifted back to amino acid residues 700, suggesting this variant is more virulent than the original SARS-COV-2 strain. Another important characteristic our study reveals is that the distance between the divergent mean and the maximal divergent point in each of the viruses (MERS>SARS-CoV-1>SARS-CoV-2) is proportional to viral fatality rate. This algorithm may help to understand and analyze the evolving trends and critical characteristics of SARS-COV-2 variants, other coronaviral proteins and viruses.

Working Paper ARTICLE

Predicting the Curvature of the Cosmos, and Point of Volume Contraction in a Big Bounce Scenario

Christopher Pilot

Subject: Physical Sciences, Acoustics Keywords: Big Bounce Model, Closed Universe, Cosmological Curvature, Big Crunch, Cyclic Universe, Heat Engine Model for Universe

Online: 16 February 2021 (13:41:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0130.v1

A Novel Treatment of the Josephson Effect

Jacob Szeftel, Nicolas Sandeau, Michel Abou Ganthous

Subject: Physical Sciences, Acoustics Keywords: Josephson effect; transport properties; critical current; tunnelling; superconducting-normal transition; negative resistance

Online: 4 February 2021 (10:01:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0568.v1

Perceived Help-Seeking Difficulty, Barriers, Delay, and Burden in Carers of People with Suspected Dementia

Carmen KM Ng, Dara KY Leung, Xinxin Cai, Gloria HY Wong

Subject: Business, Economics And Management, Accounting And Taxation Keywords: service accessibility; dementia knowledge; affordability; carer role strain; self-criticism; negative emotions

Online: 27 January 2021 (16:15:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0181.v2

Metamaterials Demonstrating Negative Thermal Capacity

Edward Bormashenko, Evgeny Shulzinger

Subject: Chemistry And Materials Science, Biomaterials Keywords: metamaterials; negative effective mass; negative density; negative thermal capacity; resonance.

Online: 26 January 2021 (11:36:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0517.v1

Metabolite Transporter and Its Impact on Metabolic Engineering Approaches

Mostafa Gomaa FADL

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gram-negative bacterial; Metabolite transporter; pathways; metabolic engineering approaches

Online: 25 January 2021 (15:49:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0491.v1

Biotope Impact on Fluctuating Asymmetry Manifestation in Ground beetles (Coleoptera, Carabidae)

Raisa A. Sukhodolskaya, Anatoliy A. Saveliev, Natalia I. Eremeeva, Nadezhda L. Ukhova, Tatyana A. Gordienko, Rifgat R. Shagidullin, Iraida G. Vorobyova, Igor A. Solodovnikov, Anatoliy Anciferov

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: fluctuating asymmetry; ground beetles; morphometric variation; biotope impact; species*biotope interaction; negative relationship between dimensional and meristic traits

Online: 21 December 2020 (10:16:14 CET)

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