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Preprint ARTICLE | doi:10.20944/preprints201803.0133.v1

Association of Blood Pressure with Blood Lead and Cadmium Levels in Korean Adolescents: Analysis of Data from the 2010–2016 Korean National Health and Nutrition Examination Survey

Jaeouk Ahn, Nam-Soo Kim, Byung-Kook Lee, Jungsun Park, Yangho Kim

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: hypertension; lead; cadmium; blood pressure; combined exposure

Online: 16 March 2018 (07:22:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0136.v1

Multimarker Approach to Evaluate the Exposure to Electromagnetic Fields at 27 GHz (5g) On Danio rerio larvae

Roberta Pecoraro, Santi Concetto Pavone, Elena Maria Scalisi, Sara Ignoto, Carmen Sica, Fabiano Capparucci, Carmelo Iaria, Antonio Salvaggio, Gino Sorbello, Loreto Di Donato, Maria Violetta Brundo

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: millimeter waves; zebrafish; DanioScope; biomarkers of exposure; SAR.

Online: 11 January 2022 (12:22:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0006.v1

Participatory Prototyping to Inform the Development of a Remote UX Design System in Automotive

Stavros Tasoudis, Mark Perry

Subject: Computer Science And Mathematics, Computer Science Keywords: User Experience; Remote UX; Participatory design; Co-creation; Prototyping; Automotive user interfaces; Autonomous Vehicles; Automotive.

Online: 1 August 2018 (08:31:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0121.v1

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Laure-Alix Clerbaux, Maria Cristina Albertini, Núria Amigó, Anna Beronius, Gillina F.G. Bezemer, Sandra Coecke, Evangelos P. Daskalopoulos, Giusy Del Giudice, Dario Greco, Lucia Grenga, Alberto Mantovani, Amalia Muñoz, Elma Omeragic, Nikolaos Parissis, Mauro Petrillo, Laura A. Saarimäki, Helena Soares, Kristie Sullivan, Brigitte Landesmann

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: SARS-CoV-2 infection; COVID-19; modulating factors; Adverse Outcome Pathway; sex; age; co-morbidities; lifestyle; environment; pre-existing conditions

Online: 8 June 2022 (09:47:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0491.v1

On the nature of evidence and 'proving' causality: smoking and lung cancer vs. sun exposure, vitamin D and multiple sclerosis

Robyn Lucas, Rachael Rodney Harris

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: epidemiology, causality, association, smoking, lung cancer, vitamin D, sun exposure, multiple sclerosis

Online: 29 June 2018 (15:42:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0128.v2

Conjunctivitis and Exposure to Ambient Ozone

Mieczyslaw Szyszkowicz, Ariela Gordon Shaag, Einat Shneor

Subject: Medicine And Pharmacology, Ophthalmology Keywords: air pollution; conjunctivitis; exposure; linear; model; case-crossover; poisson

Online: 17 April 2019 (11:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0056.v1

Electrodeposition of Co-B/SiC Composite Coatings: Characterization and Evaluation of Wear Volume and Hardness

A. Villa-Mondragón, A. Martínez-Hernández, F. Manríquez, Y. Meas, J.J. Pérez-Bueno, Francisco J. Rodríguez-Valadez, J.C. Ballesteros, J. Morales-Hernández, Alia Méndez-Albores, G. Trejo

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Co-B/SiC composite coatings; electrodeposition; hard coatings; wear volume

Online: 4 April 2019 (12:52:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0505.v2

Non-coronavirus Genome Sequences Identified from Metagenomic Analysis of Clinical Samples from COVID-19 Infected Patients: An Evidence for Co-infection

Mohamed Abouelkhair

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Viral Co-infection; SARS-CoV-2; Influenza A virus; Human Immunodeficiency virus

Online: 18 June 2020 (04:57:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0203.v1

Synthesis of Cu,N-Doped TiO₂ Nanotube and Study on Photoelectric Properties

Yiming Liu , Yanhao Sun, Zhuobin Yu, Wanggang Zhang, Peide Han

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Titanium dioxide nanotube, photoelectric properties, co-doping, magnetron sputtering

Online: 10 August 2018 (09:43:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0089.v1

Estimation of PM₁₀ Health Impacts on Human within Urban Areas of Makkah city, KSA

Atef M. F. Mohammed

Subject: Environmental And Earth Sciences, Pollution Keywords: PM10; Exposure; Health risk assessment; Makkah

Online: 14 December 2017 (11:06:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0144.v1

Co-Expression Networks for Causal Gene Identification Based on RNA-seq Data of Corynebacterium Pseudotuberculosis

Edian F. Franco, Pratip Rana, Ana Lidia Queiroz Cavalcante, Artur Luiz da Silva, Adriana R Carneiro Folador, Vasco Azevedo, Preetam Ghosh, Rommel T. J. Ramos

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Corynebacterium pseudotuberculosis; RNA-Seq; co-expression networks; influence genes; stress condition; causal genes

Online: 12 June 2020 (08:46:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0091.v1

Co-Creating Value in Urban Public Policy Context: A Different Approach

Federica Fotino

Subject: Business, Economics And Management, Business And Management Keywords: Sustainability; Value co-creation; Viable Systems Approach; Consonance; Urban and Territory development; Public Policy

Online: 14 December 2017 (11:33:32 CET)

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Urban areas face daunting economic challenges that have increased in scope in recent years. At the same time, cities provide for opportunities for growth and value creation. The interplay of these challenges and opportunities represents the area of intervention for policymakers and researchers. However, the traditional approach to urban policy, deriving from the managerial and economic policy theories, shows difficulties mainly related to the capacity to counterbalance the interests and expectations of a multitude of stakeholders participating to the value co-creation process and to bring all different components to synergically contribute to the sustainability of the system. The Author proposes an innovative approach to urban public policy, by adopting the theoretical corpus of the Viable Systems Approach ("VSA"). Urban planning will be particularly analysed, as systemic components of urban areas, with the aim to investigate the decision-making processes for an integrated, efficient, effective and sustainable management of the territory as a multidimensional, multisectoral and multi-stakeholder entity. By recovering different settings, the VSA intends the co-creation of value as the capacity of the viable systems to increase its surviving chances in its own context. The value derives, first of all, from the strategic decisions aimed at finding both dyadic and context consonance. Through its strategic decisions, the Governing Body of the territory develops a specific system as the overall synthesis of all possible systems organised within a specific area, identifying pattern of development agreed by the several stakeholders of the territory. In the dynamics of value co-creation in systemic multi-subjective organizations, where the level of complexity is particularly significant, the research for consonance among different stakeholders is particular important in order to achieve the most value for the territory. In this respect, the VSA may constitute a valid tool, helping to find the necessary capacities to imagine evolutionary paths towards new competencies.

Preprint REVIEW | doi:10.20944/preprints202003.0258.v1

Children's Health in the Digital Age

Birgitta Dresp-Langley

Subject: Public Health And Healthcare, Primary Health Care Keywords: digital environments; over exposure; children; vitamin D; melatonin; myopia; sleep loss; depression; obesity internet addiction; serotonin; dopamine; oxidative stress

Online: 16 March 2020 (04:22:15 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0238.v1

A radio-fluorogenic polymer-gel makes fixed fluorescent images of complex radiation fields

John Warman, Matthijs deHaas, Leonard Luthjens, Antonia Denkova, Tiantian Yao

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Keywords: 3D dose imaging; radio-fluorogenic gel; polymer gel dosimetry; radio-fluorogenic co-polymerization; tertiary-butyl acrylate gel; proton beam imaging

Online: 14 June 2018 (16:05:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0848.v1

The Who, Where, and What of the Highly Cited Papers in Sustainability from 2009 to 2023: A Bibliometric Analysis

Jen Jang Sheu, Chang-Yen Lee

Subject: Social Sciences, Education Keywords: bibliometric analysis; Sustainability; co-occurrence; thematic map

Online: 24 April 2023 (10:16:05 CEST)

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This paper presents a bibliometric analysis of highly cited papers published in the journal Sustainability between 2009 and 2023. The aim is to identify influential countries, authors, and papers, as well as patterns in authorship and citation trends. The analysis focuses on frequently cited sources, the most cited research papers and references within the journal, and trends in author keywords. The analysis shows that Sustainability is a leading publication in sustainability research, with an annual growth rate of 53.57%. The selected papers, published between 2013 and 2022, have an average age of 2.11 years and an average of 88.12 citations each. The study highlights the most influential countries in sustainability research published in Sustainability, with China leading, followed by the United States and Germany. The most prolific authors are from China, Spain, and Italy. Interdisciplinary collaboration is essential to address complex sustainability challenges, as shown in the papers published in Sustainability. The study emphasizes the importance of staying informed about emerging trends and research directions in the field of sustainability published in this journal Sustainability. It underscores the significance of fostering international collaborations and partnerships to address complex sustainability challenges facing our world today, as evidenced by the papers published in Sustainability. Overall, this bibliometric analysis provides valuable insights into the current state of sustainability research published in Sustainability and its implications for policy and practice. It highlights key areas for future research and underscores the need for interdisciplinary collaboration to address complex sustainability challenges, as demonstrated by the papers published in Sustainability. These findings have important implications for policymakers, researchers, and practitioners interested in promoting sustainable development in the field of sustainability., as published in Sustainability.

Preprint ARTICLE | doi:10.20944/preprints202004.0483.v1

Andrio Adwibowo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: city; CO; COVID 19; emission; social distancing

Online: 28 April 2020 (07:36:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0073.v1

Classification for Liver Diseases Based on Ultrasound Image Texture Features

Sendren Sheng-Dong Xu, Chien-Tien Su, Chun-Chao Chang, Pham Quoc Phu

Subject: Medicine And Pharmacology, Other Keywords: Classification; F-score; Gray-Level Co-occurrence Matrix (GLCM); Gray-Level Run-Length Matrix (GLRLM); Hepatocellular Carcinoma (HCC); Liver Cancer; Liver Abscess; Image Texture, Sequential Backward Selection (SBS); Sequential Forward Selection (SFS); Support Vector Machine (SVM); Ultrasound Image.

Online: 4 October 2018 (14:01:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0536.v1

Pt Nanocluster Co-Catalysts for Photocatalytic Water Splitting

Cameron Shearer, Jason F. Alvino, Munkhbayar Batmunkh, Gregory Metha

Subject: Chemistry And Materials Science, Nanotechnology Keywords: photocatalysis, co-catalysts, water splitting, metallic cluster

Online: 27 July 2018 (09:33:40 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints201806.0014.v1

Piloting a Developmental Screening Tool Adapted for East African Children

Mollika A. Sajady, Christopher J. Mehus, Emily C. Moody, Ericka G. Jaramillo, Ezekiel Mupere, Andrew J. Barnes, Sarah E. Cusick

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: development; milestones; screening; poverty; stunting; lead exposure; developmental risk; child health; global health; pediatrics

Online: 1 June 2018 (11:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0571.v1

Full Length Transcriptome Highlights the Coordination of Plastid Transcript Processing

Marine Guilcher, Arnaud Liehrmann, Chloé Seyman, Thomas Blein, Guillem Rigaill, Benoit Castandet, Etienne Delannoy

Subject: Biology And Life Sciences, Plant Sciences Keywords: Arabidopsis thaliana; plastid; co-maturation; post-transcriptional; Nanopore

Online: 31 August 2021 (11:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0322.v1

Transporter Associated with Antigen Processing 1 (TAP1) as a Potential Biomarker for Breast, Lung, Liver and Ovarian Cancer using Health Informatics

Anika Tabassum, Md. Nazmus Samdani, Tarak Chandra Dhali, Rahat Alam, Foysal Ahammad, Abdus Samad, Tomasz M. Karpiński

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TAP1; transcriptional expression; methylation analysis; survival analysis; co-expression; pathway analysis; health informatics

Online: 14 August 2020 (11:17:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0272.v1

Habitat Climate Change Vulnerability Index Applied to Major Vegetation Types of the Western Interior United States

Patrick J. Comer, Jon C. Hak, Marion S. Reid, Stephanie Auer, Keith Schulz, Healy Hamilton, Regan Smyth, Matthew Kling

Subject: Environmental And Earth Sciences, Environmental Science Keywords: adaptive capacity; climate change vulnerability; exposure; resilience; sensitivity; vegetation

Online: 22 May 2019 (09:55:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0216.v1

Temporal Dominance of B.1.1.7 over B.1.354 SARS-CoV-2 Variant: A Hypothesis Based on Areas of Variant Co-Circulation

Evangelia Georgia Kostaki, Ioulia Tseti, Sotirios Tsiodras, George N. Pavlakis, Petros P. Sfikakis, Dimitrios Paraskevis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; variants; co-circulation; dominance; vaccines

Online: 7 April 2021 (17:24:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0587.v1

Magneto-Optic Surface Plasmon Resonance Ti/Au/Co/Au/Pc Configuration and Sensitivity

Conrad Rizal

Subject: Engineering, Bioengineering Keywords: Ti/Au/Co/Au; X-ray diffraction; MOSPR; sensitivity; polycarbonate plastics

Online: 30 July 2018 (11:55:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0057.v1

Assessment of Microplastic Impacts in the Marine Environment: A Review

Tony Walker

Subject: Environmental And Earth Sciences, Environmental Science Keywords: impacts; microplastics; marine environment; single-use plastics; co-management initiatives

Online: 4 October 2021 (12:23:39 CEST)

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Working Paper ARTICLE

Design and Demonstration of Compact, High Bandwidth Optical Mode Selective Devices by Realizing ITO-Based Controllable Phase Shifters Integrated on Silicon-on-Insulator Waveguides

Cao Dung Truong, Hai Ta Duy, Duy Nguyen Thi Hang, Thuy Tran Thi Thanh, Duy Duong Quang, Hoang Chu Duc

Subject: Physical Sciences, Acoustics Keywords: co-design; ITO; thermo-optic phase shifter; mode selective converter; mode selective router; numerical simulation

Online: 14 April 2021 (10:13:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0123.v1

Environmental Lead Exposure and Adult Literacy in Myanmar: An Exploratory Study of Potential Associations at the Township Level

Robert C. MacTavish, Liam W. Remillard, Colleen M. Davison

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: lead exposure; adult literacy; global health; environmental health; Myanmar

Online: 10 April 2018 (09:51:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0269.v1

Melt Processing and Characterization of Biodegradable Poly(butylene succinate-co-adipate)/Hexadecylamine-Modified Layered Zinc Phenylphosphonate Nanocomposites

Dong-Lin Kuo, Erh-Chiang Chen, Tzong-Ming Wu

Subject: Chemistry And Materials Science, Biomaterials Keywords: poly(butylene succinate-co-adipate); zinc phenylphosphonate; nanocomposites; crystallization; biodegradation

Online: 21 May 2018 (11:40:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0744.v1

Methodology for Addressing Infectious Aerosol Persistence in Real-Time Using Sensor Network

Sepehr Makhsous, Joelle M. Segovia, Jiayang He, Daniel Chan, Larry Lee, Igor V Novosselov, Alexander V Mamishev

Subject: Engineering, Electrical And Electronic Engineering Keywords: Aerosols; dental clinics; infection control; high-volume evacuation; extra-oral suction device; particle concentration; sensor network; dispersion modeling; exposure assessment; air quality

Online: 28 April 2021 (10:32:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0323.v1

Cross-Reactivity of Zika and Other Flaviviruses in Serological Diagnostics

Kelli L. Barr, Erika R. Schwarz, Dhani Prakoso, Kehkashan Imtiaz, Ruiyu Pu, J. Glenn Morris Jr., Erum Khan, Maureen T. Long

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Zika virus; flavivirus; cross-reactivity; neutralization; diagnostics; serology; plaque reduction neutralization test; flavivirus exposure

Online: 27 November 2019 (03:45:37 CET)

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Working Paper ARTICLE

A Study on the Co-Creation of Value in Service Ecosystem: An Appraisal of the Platform of My Health Bank of National Health Insurance

Yu-Hua Yan, Shih-Chieh Fang

Subject: Social Sciences, Law Keywords: value co-creation; National Health Insurance; My Health Bank; Service Ecosystem

Online: 22 January 2020 (02:55:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0021.v1

Tailored Biodegradable and Electroactive Poly(hydroxybutyrate-co-hydroxyvalerate) Based Morphologies for Tissue Engineering Applications

Luís Amaro, Daniela M. Correia, Teresa Marques-Almeida, Pedro M. Martins, Leyre Pérez, Jose Luis Vilas, Gabriela Botelho, Senentxu Lanceros-Mendez, Clarisse Ribeiro

Subject: Chemistry And Materials Science, Biomaterials Keywords: biomaterials; cobalt ferrites; poly(hydroxybutyrate-co-hydroxyvalerate); tissue engineering

Online: 3 July 2018 (05:12:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0130.v1

Assessment and Calibration on Low-cost PM2.5 Sensor using Machin Learning (Hybrid-LSTM Neural Network): Feasibility Study to Build Air Quality Monitoring System

Donggeun Park, Geon-Woo Yoo, Seong-Ho Park, Jong-Hyeon Lee

Subject: Environmental And Earth Sciences, Environmental Science Keywords: machine learning; deep learning; calibration; air quality; low-cost sensors; exposure assessment

Online: 7 September 2021 (14:24:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0373.v1

Decoding the Relationship of Artificial Intelligence, Advertising, and Generative Models

Han Woo Park, Camille Velasco Lim, Yu Peng Zhu, Muhammad Omar

Subject: Business, Economics And Management, Marketing Keywords: generative AI advertising; artificial intelligence advertising; machine learning advertising; bibliometrics; full counting; co-occurrence network analysis; co-author network analysis

Online: 4 January 2024 (08:59:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0518.v1

Data Fusion and Visualization of a Multi-Sensor Personal Exposure Campaign

Rok Novak, Ioannis Petridis, David Kocman, Johanna Amalia Robinson, Tjaša Kanduč, Dimitris Chapizanis, Spyros Karakitsios, Benjamin Flückiger, Danielle Vienneau, Ondřej Mikeš, Celine Degrendele, Ondřej Sáňka, Saul García Dos Santos-Alves, Thomas Maggos, Dementra Pardali, Asimina Stamatelopoulou, Dikaia Saraga, Marco Giovanni Persico, Jaideep Visave, Alberto Gotti, Dimosthenis Sarigiannis

Subject: Environmental And Earth Sciences, Environmental Science Keywords: data fusion; multi-sensor; data visualization; data treatment; participant reports; air quality; exposure assessment

Online: 30 September 2021 (14:13:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0143.v1

Research on the Visualization of Ocean Big Data Based on the Cite-Space Software

Jiajing Wu, Dongning Jia, Zhiqiang Wei, Xin Dou

Subject: Computer Science And Mathematics, Information Systems Keywords: ocean; big-data; cite-space; co-authorship analysis; co-citation analysis; keywords co-occurrence analysis; visualization

Online: 11 February 2020 (09:41:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0405.v2

Effectiveness of Prevailing Flush Guidelines to Prevent Exposure to Lead in Water

Adrienne Katner, Kelsey Pieper, Komal Brown, Hui-Yi Lin, Jeffrey Parks, Xinnan Wang, Chih-yang Hu, Sheldon Masters, Howard Mielke, Marc Edwards

Subject: Environmental And Earth Sciences, Environmental Science Keywords: drinking water; lead; Pb; flush; exposure prevention; intervention; lead service line

Online: 29 May 2018 (09:39:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0725.v1

Maize (Zea Mays L) Production in a Semiarid Area of South Africa from Co-Application of Biogas Slurry with Chemical Fertilizer and Effects on Soil Quality

Thandile Mdlambuzi, Mitsuru Tsubo, Pardon Muchaonyerwa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: dry matter yield; nutrient uptake; soil nutrient reserves; co-application; grain yield; dryland

Online: 30 March 2021 (10:18:06 CEST)

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Most smallscale farmers still use the traditional way of agricultural crop farming, and relay mostly use of chemical fertilizers (CF). Recently CF have become expensive and could in some way have a negative impact on soil quality after long term application. However, co-application of biogas slurry (BGS) with CF could help reduce farming costs while improving dry matter yields, grain yields, primary macronutrient uptake of (Nitrogen) N, (Phosphorus) P, (Potasium) K, (Calcium) Ca and (Magnesium) Mg and soil concentration of pH, (organic carbon) OC, N, P, K, Ca and Mg after crop harvest. The study was a field experiment conducted in 2016-2017 and 2017-2018 growing seasons. The field experiment was arranged in a randomized complete block design with four replicates. The treatments were based on percentages of recommended N rates of 120 kg N ha-1 for maize production. The BGS/CF treatments were (i) 0/0, (ii) 0/120, (iii) 24/96, (iv) 48/72, (v) 72/48, (vi) 96/24, (vii) 120/0 kg N ha-1. The spreading of the combination of BGS/CF treatments was performed by hand and incorporated into the top soil (0-10 cm) in each experimental plots. BGS/CF (48/72) treatment resulted into higher dry matter yield in 2016-2017, which was higher than all other treatment combinations, while in the 2017-2018 season, treatment of (0/120) resulted into higher dry matter than all other treatment combinations. The 48/72 and 0/120 treatments resulted into similar grain yield in 2016-2017 season which were higher than all other treatments. Treatments of 48/72, 72/48 and 120/0 had higher N, P, K, Ca and Mg uptake than 0/0, 0/120, 24/96 and 96/24 treatments in both seasons. Soil pH, total N, K, and Mg were high from the treatment of (120/0) than all other treatments in 2016-2017 while in the 2017-2018 season, treatment of (48/72) had higher OC, P and K after maize harvest. The findings of his study show that co-application of BGS/CF at 48/72 and 72/48 have maize yield benefits compared to the two resources, BGS/CF (120/0) and BGS/CF (0/120), applied separately in soil especially in the arid and semi-arid regions.

Preprint ARTICLE | doi:10.20944/preprints201805.0193.v1

Pastoral Resilience among the Maasai Pastoralists of Laikipia County, Kenya

Edwin Ambani Ameso, Salome Atieno Bukachi, Charles Owuor Olungah, Tobias Haller, Simiyu Wandibba, Steve Nangendo

Subject: Social Sciences, Sociology Keywords: pastoral resilience; co-management concept; decentralization; holistic management; water-shed management plan; commercialization of herding; Common Pool Resources

Online: 14 May 2018 (12:10:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0503.v1

In-vitro Investigation of Polymeric Lipid Hybrid Nanoparticles (Plhns) Of a Chemotherapeutic Drug for the Treatment of Glioblastoma Multiforme

Sankha Bhattacharya

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cytotoxicity; Glioblastoma multiform; Lactate dehydrogenase (LDH); Poly D- L-lactic-co-glycolic acid (PLGA); U-87 MG glioma cell lines

Online: 21 July 2021 (16:37:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0143.v1

Treatment Inefficacy for Salmonella During Schistosoma-Salmonella Co-Infections Background, Mechanisms and Future Exploration

Ousman Bajinka, Richard Bradbury, Mingming Qi, Amadou Barrow, Abdoulie O Touray, Yurong Tan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Co-infection; Drug resistance; Gut microbiota; Salmonellosis; Schistosoma

Online: 7 May 2021 (12:02:03 CEST)

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Working Paper ARTICLE

Deleterious Behaviorally Tansmitted Traits in Equilibrium

Robert Shuler

Subject: Business, Economics And Management, Accounting And Taxation Keywords: culture; co-evolution; meme; altruism; natural selection; competitive equilibrium; Fermi Paradox: memetics; genetics

Online: 10 February 2021 (16:31:42 CET)

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Working Paper REVIEW

Law and Regulations to Control Pesticide Exposure Among the General Population: Comparing the Australian and the European Union Pesticide Regulatory System

Maisarah Nasution Waras, Kateryna Babina, Ismaniza Ismail, Claire E. Lenehan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: pesticide regulation; pesticide exposure; pesticide policy; non-occupational pesticide exposure; human health; pesticide pollution

Online: 4 December 2020 (15:09:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0299.v1

Efficiency and Effectiveness of the European Parliament under the Ordinary Legislative Procedure

Ani Matei, Cristina Ciora, Reli Ceche, Adrian Stelian Dumitru

Subject: Business, Economics And Management, Business And Management Keywords: European Parliament , Ordinary Legislative Procedure, Co-decision, Efficiency,Effectiveness

Online: 25 December 2018 (08:44:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0132.v1

Methods for Analyzing Surface Texture Effects of Volcanoes with Plinian and Subplinian Eruptions Types: Cases of Study Lascar (23° 22' S) and Chaiten (42 ° 50' S), Chile

Luis Fernández, Gabriel Álvarez, Renato Salinas

Subject: Environmental And Earth Sciences, Environmental Science Keywords: subplinian eruption; co-occurrence matrix; wavelet transform; similarity metrics

Online: 8 June 2018 (12:33:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0165.v1

Prevalence, Risk Factors and Residential Variation among HIV/TB co-infected Mortality in Amhara Region, Fenote Selam Hospital: Application of Multilevel Logistic Regression

Berhanu Bekele Debelu

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: HIV/TB co-infected Mortality; Residential Variations; Multilevel Logistic Regression

Online: 12 January 2022 (13:34:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0410.v1

Developing an Integrative Theoretical Framework for Climate Proofing Spatial Planning Across Sectors, Policy Levels and Planning Areas

Maria Juschten, Florian Reinwald, Roswitha Weichselbaumer, Alexandra Jiricka-Pürrer

Subject: Social Sciences, Geography, Planning And Development Keywords: climate proofing; spatial planning; climate change adaptation; framework; cross-regional; integral; co-benefits

Online: 18 May 2021 (10:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0208.v1

Lactobacillus Acidophilus DDS-1 Modulates the Gut Microbial Co-Occurrence Networks in Aging Mice

Ravichandra Vemuri, Christopher J. Martoni, Kylie Kavanagh, Rajaraman Eri

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; intestinal microbiota; dysbiosis; probiotics; microbial co-occurrences

Online: 17 February 2022 (10:59:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0188.v2

Co-application of Biochar-Compost and Inorganic Nitrogen Fertilizer Affects the Growth and Nitrogen Uptake by Lowland Rice in Northern Ghana

Daniel Asiamah Aboagye, Wilfred TJ Adjadeh, Stella Asuming-Brempong, Eric Kwesi Nartey

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Co-composted Biochar; Nitrogen Uptake; Nitrogen Use Efficiency; Eutric Gleysol; Northern Ghana

Online: 26 April 2022 (10:02:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0253.v1

Calculating Point Cloud Object Volume Using Co-Opposite-Direction Slicing Method

Bin Li, Xiaowei Bi, Cheng Peng, Yong Chen, Xiaofa Zhao, Chengsheng Yang

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: point cloud objects (PCOs); volume calculation (VC); co-opposite-direction slicing method (CODSM); systematic directional errors; random errors

Online: 22 November 2019 (05:37:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0168.v2

Awareness of Adverse Health Effects of Silica Dust Exposure Among Stone Quarry Workers in Ghana

Dzifa Francis Ahadzi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: awareness, adverse health effects, exposure, stone quarry workers, silica dust

Online: 13 May 2021 (11:02:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0042.v1

Feasibility Evaluation of CFD Approach for Inhalation Exposure Assessment: Case Study for Biocide Spray

Donggeun Park, Jong-Hyeon Lee

Subject: Environmental And Earth Sciences, Environmental Science Keywords: inhalation exposure assessment; computational fluid dynamics (CFD); biocides; spray model; unsteady RANS

Online: 4 January 2021 (13:17:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0416.v1

All Femtosecond Optical Pump and X-Ray Probe: Holey-Axicon for Free Electron Laser

Vijayakumar Anand, Jovan Maksimovic, Tomas Katkus, Soon Hock Ng, Orestas Ulcinas, Mindaugas Mikutis, Justas Baltrukonis, Antanas Urbas, Gintas Slekys, H. Ogura, Daisuke Sagae, Tatiana Pikuz, Toshihiro Somekawa, Norimasa Ozaki, Arturas Vailionis, Gediminas Seniutinas, Vygantas Mizeikis, Karl Glazebrook, Jean P. Brodie, Paul R. Stoddart, Ludovic Rapp, Andrei V. Rode, Eugene G. Gamaly, Saulius Juodkazis

Subject: Physical Sciences, Quantum Science And Technology Keywords: X-rays; free electron laser (FEL); ultra-short phenomena; pump-probe; warm-dense matter; astrophotonics; co-axial volumetric interaction diagnostics

Online: 26 May 2020 (03:53:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0199.v1

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Montse Marquès, Jose L Domingo

Subject: Medicine And Pharmacology, Hematology Keywords: polychlorinated dibenzo-p-dioxins (PCDDs); polychlorinated dibenzo-p-furans (PCDFs); human exposure; blood samples; dietary intake; risks

Online: 20 August 2019 (04:20:00 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202004.0043.v1

Maternal Fasting or Fluid Abstention Does Not Significantly Affect the Macronutrient Composition of Human Milk: Clinical and Clinical Research Relevance

Karel Allegaert, anne smits

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: lactation; physiology-based lactation models; drug exposure prediction; fasting; drug safety; newborn; infant; human milk

Online: 6 April 2020 (09:11:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0143.v1

Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella typhimurium

Logan Gildea, Joseph Ayariga, Junhuan Xu, Robert Villafane, Robertson Boakai, Michelle Samuel-Foo, Olufemi Ajayi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella; novel antibacterial agents; cannabidiol; co-therapy; bacterial genetics

Online: 12 September 2022 (09:55:22 CEST)

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Working Paper ARTICLE

Seroprevalence of SARS-CoV-2 Infection Among Occupational Groups from Bucaramanga Metropolitan Area, Colombia

Claudia C. Colmenares-Mejía, Norma Serrano-Díaz, Doris C. Quintero-Lesmes, Ligia Meneses, Isail Salazar Acosta, Álvaro J. Idrovo, Duván Y. Sanabria-Echeverry, Helmer Cordero-Rebolledo, Víctor Castillo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Seroepidemiologic Studies; Prevalence; Coronavirus Infections; Occupational Exposure; Occupational Health

Online: 25 March 2021 (15:11:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0107.v1

On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Francesca Costabile, Stefano Decesari, Roberta Vecchi, Franco Lucarelli, Gabriele Curci, Dario Massabò, Matteo Rinaldi, Maurizio Gualtieri, Emanuela Corsini, Elena Menegola, Silvia Canepari, Lorenzo Massimi, Stefania Argentini, Maurizio Busetto, Gianluca Di Iulio, Luca Di Liberto, Marco Paglione, Igor Petenko, Mara Russo, Angela Marinoni, Gianpietro Casasanta, Sara Valentini, Vera Bernardoni, Federica Crova, Gianluigi Valli, Alice Corina Forello, Fabio Giardi, Silvia Nava, Giulia Pazzi, Paolo Prati, Virginia Vernocchi, Teresa La Torretta, Ettore Petralia, Milena Stracquadanio, Gabriele Zanini, Gloria Melzi, Emma Nozza, Martina Iulini, Donatella Caruso, Lucia Cioffi, Gabriele Imperato, Flavio Giavarini, Maria Battistoni, Francesca Di Renzo, Maria Agostina Frezzini, Cinzia Perrino, Maria Cristina Facchini

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: atmospheric aerosol; chemical composition; secondary aerosol; source apportionment; ultrafine particles; oxidative potential; exposure; toxicology; forecasting; micrometeorology

Online: 12 April 2022 (09:54:57 CEST)

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Working Paper ARTICLE

Effect of W on the Evolution of Precipitates in Ni-Co-Cr-W-Mo Super-Alloys

Hansheng Bao, Zhihua Gong, Zhengzong Chen, Gang Yang, Zhengdong Liu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: nickel-based super-alloys; M6C; u phase; long time exposure; M12C

Online: 16 September 2019 (01:22:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0169.v1

Improved Multifactor Portfolio Optimization Method through Empirical Research in South Korea

DongJun Lee

Subject: Business, Economics And Management, Finance Keywords: asset allocation; risk factor; risk exposure; macro-factor

Online: 12 May 2022 (10:44:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0452.v1

Performance Analysis of an Intermediate Temperature SOE Test Bench Under CO₂-H₂O Feeding Stream

Petronilla Fragiacomo, Giuseppe De Lorenzo, Orlando Corigliano

Subject: Engineering, Energy And Fuel Technology Keywords: CO/H2 production; intermediate temperature SOEC; SOEC modeling; performance analysis

Online: 24 July 2018 (10:20:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0484.v1

The Relationship between Nature Deprivation and Individual Wellbeing across Urban Gradients under COVID-19

Linda Powers Tomasso, Jie Yin, Jose Guillermo Cedeno Laurent, Jarvis T. Chen, Paul Catalano, John D. Spengler

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: nature exposure; nature deprivation; health disparities; wellbeing; built environment; urban health interventions

Online: 21 December 2020 (09:00:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0234.v1

Physical Analysis of SARS-CoV-2 Routes: from Primary Production and Emissions to Exposures and COVID-19 Infection

Gjalt Huppes, Ruben Huele

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID-19; virions mass balance; spatial modelling of toxics concentrations; human exposure to airborne substances; Substance Flow Analysis (SFA); environmental routes of toxic viruses; primary production of SARS-2 virions

Online: 17 May 2022 (14:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0282.v1

Enjoying the heat? Co-creation of stakeholder benefits and sustainable energy development within projects in the geothermal sector

David Cook, Ingibjörg Karlsdóttir, Inga Minelgaite

Subject: Business, Economics And Management, Business And Management Keywords: Project management; geothermal; co-benefits; sustainable development; innovation, operationalization

Online: 19 January 2022 (16:08:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0258.v1

Prevalence of Co-Infections With Respiratory Viruses in Individuals Investigated for Sars-Cov-2 in Ontario, Canada

Adriana Peci, Vanessa Tran, Jennifer L Gurtherie, Ye Li, Paul Nelson, Kevin L Schwartz, Sara A Buchan, Jonathan B Gubbay

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: co-infection; SARS-CoV-2; Covid-19; seasonal respiratory viruses

Online: 10 December 2020 (12:53:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0378.v1

Variation of Deoxynivalenol levels in Corn and Its Products Available in Retail Markets of Punjab, Pakistan and Estimation of Risk Assessment

Shahzad Zafar Iqbal, Ahmad Faizal Abdull Razis, Sunusi Usman, Nada Basheir Ali, Muhammad Rafique Asi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: DON; corn; corn products; exposure; risk assessment

Online: 15 March 2021 (12:04:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0164.v1

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and Human Cells

Ines Reigada, Ramón Pérez-Tanoira, Jayendrakumar Patel, Kirsi Savijoki, Jari Yli-Kauhaluoma, Teemu J. Kinnari, Adyary Fallarero

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: biofilm; co-culture; Staphylococcus aureus; SaOS-2; biomaterials; implanted devices

Online: 12 December 2019 (05:24:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0033.v1

Whether Supercritical Extracts from the Aerial Parts of Helianthus salicifolius and Helianthus tuberosus May be Regarded as a Potential Raw Materials for Non-bioenergy Purposes?

Anna Malm, Agnieszka Grzegorczyk, Anna Biernasiuk, Tomasz Baj, Edward Rój, Katarzyna Tyśkiewicz, Agnieszka Dębczak, Mariusz Jerzy Stolarski, Michał Krzyżaniak, Ewelina Olba-Zięty

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: willow-leaf sunflower; Jerusalem artichoke; supercritical extraction; water as co-solvent; antimicrobial activity; biocidal effect

Online: 2 November 2020 (11:47:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0140.v1

In-utero Ramadan Exposure and Child Nutrition

Hoi Chu, Srinivas Goli, Anu Rammohan

Subject: Business, Economics And Management, Economics Keywords: Child nutrition; Religion; Ramadan fasting; In-utero exposure

Online: 9 February 2022 (16:00:34 CET)

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Working Paper CONCEPT PAPER

Service-Value and Nash-Equilibrium Pricing: An Axiomatic Methodology

Victor Tang

Subject: Business, Economics And Management, Accounting And Taxation Keywords: pricing services; value-pricing services; services Nash Equilibrium; value co-creation; service science; services metrology

Online: 17 April 2021 (08:51:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0321.v1

Enteroinvasive Escherichia Coli is Inefficient to Escape from Autophagy during Caco-2 Cellular Infection

Silvia Yumi Bando, Ana Carolina Ramos Moreno, Hadassa Cristhina de Azevedo Soares dos Santos, Fernanda Bernardi Bertonha, Lucas Gonçalves Ferreira, Marina Baquerizo Martinez, Carlos Alberto Moreira-Filho

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Enteroinvasive Escherichia coli; Shigella flexneri; Caco-2 cells; icsB; autophagy; WGCNA; gene co-expression network

Online: 25 February 2022 (03:16:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0585.v1

Association Analysis of Genetic Variants of Sodium Taurocholate Co-Transporting Polypeptide NTCP Gene (SLC10A1) and HBV Infection Status in a Cohort of Egyptian Patients

Maissa El Said El Raziky, Naglaa Ali Zayed, Yasmin Saad Ibrahim, Fatma Elrashdy, Rasha Mohamad Hosny Shahin, Mohamed Hassany, Magdy El Serafy, Wahid Doss, Vladimir N. Uversky, Ayman Yosry, Hadeel Gamal Eldeen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Functional receptor; Hepatitis B virus; Polymorphism; Sodium taurocholate co-transporting polypeptide; hepatic fibrosis; Egypt

Online: 26 July 2021 (14:42:42 CEST)

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Background: Single nucleotide polymorphisms (SNPs) in the SLC10A1 gene, coding for a functional receptor of hepatitis B virus (HBV), sodium taurocholate co-transporting polypeptide (NTCP), may influence the susceptibility, the outcome, and disease course of HBV infection in some populations. Aim: to determine the prevalence of SNPs of NTCP gene, rs2296651 and rs943277, and their relationship with chronic HBV infection in a group of Egyptian patients. Methods: 137 patients with HBV and 65 healthy controls were enrolled, and the patients were divided into two groups; group I chronic HBV infection (68 patients with normal ALT and minimal or no liver necroinflammation or fibrosis) and group II chronic hepatitis B (69 patients with elevated ALT and moderate or severe liver necroinflammation). They were subjected to full history taking, clinical examination, laboratory investigations, abdominal ultrasound, and liver stiffness measurement using both Echosens® Fibroscan and acoustic radiation force impulse (ARFI). Real time PCR TaqMan 5’ allelic discrimination assay was applied to detect the SNPs in NTCP gene, rs2296651 and rs943277. Results: On studying the rs2296651 variant, all controls and patients had genotype GG without any significant association with HBV infection or disease progression. However, the rs943277 variant in all controls and 98% of patients had genotype GA, except for two chronic HBV infection patients who had genotype AA, but no significant difference between patients and controls was found. The non-invasive methods for liver fibrosis assessment ARFI, AST/platelet's ratio (APRI), and fibrosis-4 score (FIB-4) could predict the stages of fibrosis in agreement with Fibroscan with AUCOR 0.8, 0.79, and 0.76, respectively. Conclusion: These findings may suggest that there is no relation between these SNPs of the NTCP gene and susceptibility or chronicity of HBV infection in the Egyptian population. We also suggest that the use of the non-invasive methods for liver fibrosis assessment, ARFI, FIB-4, and APRI may decrease the need for liver biopsies in prediction of significant hepatic fibrosis in chronic HBV patients.

Preprint ARTICLE | doi:10.20944/preprints202109.0164.v2

A High Resolution Spatiotemporal Fine Particulate Matter Exposure Assessment Model for the Contiguous United States

Cole Brokamp

Subject: Environmental And Earth Sciences, Environmental Science Keywords: fine particulate matter; exposure assessment; machine learning; spatiotemporal; high resolution

Online: 17 December 2021 (14:46:46 CET)

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Currently available nationwide prediction models for fine particulate matter (PM_2.5) lack prediction confidence intervals and usually do not describe cross validated model performance at different spatiotemporal resolutions and extents. We used 41 different spatiotemporal predictors, including data on land use, meteorology, aerosol optical density, emissions, wildfires, population, traffic, and spatiotemporal indicators to train a machine learning model to predict daily averages of PM_2.5 concentrations at 0.75 sq km resolution across the contiguous United States from 2000 through 2020. We utilized a generalized random forest model that allowed us to generate asymptotically-valid prediction confidence intervals and took advantage of its usefulness as an ensemble learner to quickly and cheaply characterize leave-one-location-out CV model performance for different temporal resolutions and geographic regions. Using a variable importance metric, we selected 8 predictors that were able to accurately predict daily PM_2.5, with an overall leave-one-location-out cross validated median absolute error of 1.20 ug/m³, an R² of 0.84, and confidence interval coverage fraction of 95%. When considering aggregated temporal windows, the model achieved leave-one-location-out cross validated median absolute errors of 0.99, 0.76, 0.63, and 0.60 ug/m³ for weekly, monthly, annual, and all-time exposure assessments, respectively. We further describe the model’s cross validated performance at different geographic regions in the United States, finding that it performs worse in the Western half of the country where there are less monitors. The code and data used to create this model are publicly available and we have developed software packages to be used for exposure assessment. This accurate exposure assessment model will be useful for epidemiologists seeking to study the health effects of PM across the continental United States, while possibly considering exposure estimation accuracy and uncertainty specific to the the spatiotemporal resolution and extent of their study design and population.

Preprint REVIEW | doi:10.20944/preprints202306.1160.v1

Drinking Water Systems as a Cocktail of Emerging Organic Contaminants: Occurrence, Public Health Risks, and Research Needs

Jerikias Marumure, Tinoziva T Simbanegavi, Zakio Makuvara, Rangarirayi Karidzagundi, Richwell Alufasi, Marvelous Goredema, Claudious Gufe, Nhamo Chaukura, Willis Gwenzi

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Human exposure; high-risk environments; human health hazards; personal care products; pharmaceuticals; per- and polyfluoroalkyl substances; risk factors

Online: 16 June 2023 (03:16:14 CEST)

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Emerging organic contaminants (EOCs) of anthropogenic origins are ubiquitous in environmental compartments, including aquatic systems. Thus, EOCs have attracted considerable research and public attention due to their potential human and ecological health risks. However, compared to other aquatic environments such as wastewater systems, comprehensive reviews focussing on the occurrence and human health risks of EOCs in drinking water systems are still lacking. Therefore, to address this knowledge gap, the current review posits that drinking water systems harbour a cocktail of toxic EOCs, which pose public health risks via multiple exposure routes. In the present review, global evidence is examined to track EOCs along the source-pathway-receptor-impact-mitigation (SPRIM) continuum. Evidence shows that, various groups of EOCs, including pharmaceuticals and personal care products, solvents, plasticizers, endocrine disrupting compounds, gasoline additives, per- and polyfluoroalkyl substances (PFAS), food colourants, artificial sweeteners, and musks and fragrances, have been detected in drinking water systems. The anthropogenic sources of EOCs detected in drinking water systems, including wastewater systems and industrial emissions, are summarized. Further, the behaviour and fate of EOCs in the drinking water systems, including removal processes are discussed. Once in drinking water systems, human exposure to EOCs may occur via ingestion of contaminated drinking water and cooked foods, and possibly dermal contact and inhalation. The high-risk environments, and risk factors and behaviours predisposing humans to EOC exposure are discussed. Evidence on the human health risks of the various EOCs and a critique of the data are presented. Notably, besides inferential data, quantitative epidemiological evidence directly relating the occurrence of EOCs in drinking water systems to specific adverse human health outcomes is still scarce. Lastly, future research directions, including the need for quantitative public health risk assessment, and the application of emerging detection tools are discussed.

Preprint ARTICLE | doi:10.20944/preprints202010.0641.v1

Aging-induced Changes in Sperm DNA Methylation are Modified by Low Dose of Perinatal Flame retardants

J.Richard Pilsner, Alex Shershebnev, Haotian Wu, Chelsea Marcho, Olga Dribnokhodova, Victoria Shtratnikova, Oleg Sergeyev, Alexander Suvorov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; paternal exposure; sperm; advanced paternal age; epigenetics; DNA methylation; RRBS, 2,2′,4,4′-tetrabromodiphenyl ether; PBDE; BDE-47; perinatal; environment

Online: 30 October 2020 (13:37:14 CET)

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Advanced paternal age at fertilization has been suggested to be a risk factor for neurodevelopmental, psychiatric and other disorders in offspring. One emerging hypothesis suggests that altered offspring phenotype is linked with age-related accumulation of epigenetic changes in the sperm of fathers. Given that paternal age is increasing in the developed world, understanding aging-related epigenetic changes in sperm is needed as well as environmental factors that modify such changes. In this study, we characterize age-dependent changes in sperm DNA methylation profiles between young pubertal (postnatal day (PNDs) 65) and mature (PND120) Wistar rats. We also analyze these changes in rats exposed perinatally to 0.2 mg/kg of ubiquitous environmental xenobiotic 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47). Reduced representation bisulfite sequencing (RRBS) libraries were prepared from caudal epididymal sperm DNA and differentially methylated regions (DMRs; ≥ 10x coverage depth, ≥ 3 CpGs per cluster, ≥ 5% methylation change, q < 0.05) were identified via MethPipe package. In control animals, 5,319 age-dependent DMRs were identified, with 99.3% DMRs hypermethylated in mature animals compared to young pubertal rats. These age-related DMRs were enriched for functional categories essential for embryonic development, such as pattern specification, forebrain and sensory organ development, Hippo and Wnt pathways. Age-related changes in sncRNA, reported in different study, target similar list of genes and biological categories.In BDE-47 exposed rats, sperm DNA methylation was higher in young pubertal and lower in mature animals when compared to controls, which resulted in a significant attenuation in the number of age-dependent DMRs (N = 189) identified in the exposed group. In conclusion, our results indicate that the natural aging process has profound effects on sperm methylation levels and this effect may be modified by environmental exposures. Moreover, our results further support the role of epigenetic mechanisms as a likely link betwen paternal age and offspring health and development.

Preprint REVIEW | doi:10.20944/preprints202102.0612.v2

A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior

Alessandro Carollo, Jan Paolo Macapinlac Balagtas, Michelle Jin-Yee Neoh, Gianluca Esposito

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Medial Preoptic Area; MPOA; Parental behavior; Scientometry; Systematic Review; CiteSpace; Document Co-Citation Analysis; Keyword Analysis

Online: 1 April 2021 (14:52:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0140.v1

Temporal and Spatial Evolution of Climate Comfort and Population Exposure in Guangdong Province in the Last Half Century

Ziqiang Ye, Song Song, Runfei Zhong

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: climate comfort index; temperature-humidity index; wind-effect index; clothing index; population exposure

Online: 11 January 2022 (13:04:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0053.v1

Analytical and Numerical Evaluation of Co-Scheduling Strategies and Their Application

Ruslan Kuchumov, Vladimir Korkhov

Subject: Computer Science And Mathematics, Mathematics Keywords: Co-scheduling; HPC; scheduling theory; stochastic optimization

Online: 3 September 2021 (10:14:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0535.v1

Explosives Use in Decommissioning – Guide for Assessment of Risk (EDGAR): II Determination of Sound Exposure Levels for Open Water Blasts and Severance of Conductors and Piles from Below the Seabed

Alison Brand

Subject: Physical Sciences, Acoustics Keywords: Underwater noise modelling; decommissioning; explosives; sound exposure level; marine mammals; fish

Online: 23 July 2021 (10:41:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0394.v1

Co-Operation among Irish Beef Farmers: Current Perspectives and Future Prospects in the Context of New Producer Organisation (PO) Legislation

Teresa Hooks, Aine Macken-Walsh, Olive McCarthy, Carol Power, Maeve Henchion

Subject: Social Sciences, Sociology Keywords: Ireland; beef farms; Producer Organisations (POs), product differentiation; co-operatives; values-based supply chain

Online: 20 September 2018 (04:16:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0549.v1

Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors

Cole D. Davidson, Noelle E. Gillis, Frances E. Carr

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: TRβ; tumor suppression; co-regulators; therapeutics

Online: 23 July 2021 (15:14:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0331.v1

Geochemical Association Rules of Elements Mined using Clustered Events of Spatial Auto-correlation: A Case Study in the Chahanwusu River Area, Qinghai Province, China

Baoyi Zhang, Zhengwen Jiang, Yiru Chen, Nanwei Cheng, Umair Khan, Jiqiu Deng

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Concentration field; Spatial auto-correlation; Association rules; Apriori algorithm; Element co-occurrence

Online: 21 January 2022 (13:42:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0288.v1

Effect of Fire Temperature and Exposure Time on High-strength Steel Bolts Microstructure and Residual Mechanical Properties

Paweł Artur Król, Marcin Wachowski

Subject: Engineering, Automotive Engineering Keywords: effect of temperature; exposure time; steel microstructure; residual mechanical properties; high-strength steel bolts; heat treatment of steel; phase transformation; fire; cooling method

Online: 13 May 2021 (12:53:32 CEST)

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The article presents results of research consisting in an attempt to assess the influence of temperature, heating time and cooling method on microstructure and residual strength properties of steel previously tempered during the production process. Simulated environmental conditions to which high-strength bolts, commonly used in steel construction, were subjected, were intended to reflect conditions of a natural fire that may occur in public facilities where the obligation to ensure safety of users and rescue teams is of key importance, also required by law. Furthermore, the tests carried out also comprised a simulated effect of a rescue and firefighting operation using shock, rapid cooling of some of the heated bolts. Samples cut out from the tested bolts, after they were properly prepared, were subjected to microstructural tests using light microscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), phase analysis with the use of an X-ray diffractometer (XRD) and quantitative analysis of the microstructure involving, inter alia, measuring the surface area of grains, their equivalent diameter and mean diameter. As a result of the tests, considerable microstructure changes were identified occurring in the bolt material as a result of exposing it to fire conditions, leading to a change in key, from the point of view of structural safety, mechanical properties. The results of the microstructure tests were compared with the results of previous strength tests, including hardness of the material after the heat treatment and the residual tensile strength of the material Rm. A conducted comparative analysis showed a significant effect of all such factors as the temperature level of the simulated fire, its duration and the fire-fighting method on the mechanical properties of bolts. Results obtained were provided with required comments and the concept of using the microstructure for the post-fire assessment of steel structures was referred to.

Preprint ARTICLE | doi:10.20944/preprints202201.0027.v1

Co-degree and Degree of classes of Neutrosophic Hypergraphs

Henry Garrett

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Degree, Coloring, Co-degree

Online: 5 January 2022 (10:24:32 CET)

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New setting is introduced to study types of coloring numbers, degree of vertices, degree of hyperedges, co-degree of vertices, co-degree of hyperedges, neutrosophic degree of vertices, neutrosophic degree of hyperedges, neutrosophic co-degree of vertices, neutrosophic co-degree of hyperedges, neutrosophic number of vertices, neutrosophic number of hyperedges in neutrosophic hypergraphs. Different types of procedures including neutrosophic (r, n)−regular hypergraphs and neutrosophic complete r−partite hypergraphs are proposed in this way, some results are obtained. General classes of neutrosophic hypergraphs are used to obtain chromatic number, the representatives of the colors, degree of vertices, degree of hyperedges, co-degree of vertices, co-degree of hyperedges, neutrosophic degree of vertices, neutrosophic degree of hyperedges, neutrosophic co-degree of vertices, neutrosophic co-degree of hyperedges, neutrosophic number of vertices, neutrosophic number of hyperedges in neutrosophic hypergraphs. Using colors to assign to the vertices of neutrosophic hypergraphs and characterizing representatives of the colors are applied in neutrosophic (r, n)−regular hypergraphs and neutrosophic complete r−partite hypergraphs. Some questions and problems are posed concerning ways to do further studies on this topic. Using different ways of study on neutrosophic hypergraphs to get new results about number, degree and co-degree in the way that some number, degree and co-degree get understandable perspective. Neutrosophic (r, n)−regular hypergraphs and neutrosophic complete r−partite hypergraphs are studied to investigate about the notions, coloring, the representatives of the colors, degree of vertices, degree of hyperedges, co-degree of vertices, co-degree of hyperedges, neutrosophic degree of vertices, neutrosophic degree of hyperedges, neutrosophic co-degree of vertices, neutrosophic co-degree of hyperedges, neutrosophic number of vertices, neutrosophic number of hyperedges in neutrosophic (r, n)−regular hypergraphs and neutrosophic complete r−partite hypergraphs. In this way, sets of representatives of colors, degree of vertices, degree of hyperedges, co-degree of vertices, co-degree of hyperedges, neutrosophic degree of vertices, neutrosophic degree of hyperedges, neutrosophic co-degree of vertices, neutrosophic co-degree of hyperedges, neutrosophic number of vertices, neutrosophic number of hyperedges have key points to get new results but in some cases, there are usages of sets and numbers instead of optimal ones. Simultaneously, notions chromatic number, the representatives of the colors, degree of vertices, degree of hyperedges, co-degree of vertices, co-degree of hyperedges, neutrosophic degree of vertices, neutrosophic degree of hyperedges, neutrosophic co-degree of vertices, neutrosophic co-degree of hyperedges, neutrosophic number of vertices, neutrosophic number of hyperedges are applied into neutrosophic hypergraphs, especially, neutrosophic (r, n)−regular hypergraphs and neutrosophic complete r−partite hypergraphs to get sensible results about their structures. Basic familiarities with neutrosophic hypergraphs theory and hypergraph theory are proposed for this article.

Preprint ARTICLE | doi:10.20944/preprints202202.0184.v1

Provider-Patient Interactions as Predictors of Lifestyle Behaviors Related to the Prevention and Management of Diabetes

Brenda Robles, Tony Kuo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: type 2 diabetes; lifestyle behaviors; healthcare provider advice; provider-patient interactions; health care setting; brief lifestyle intervention exposure; diabetes prevention; diabetes management

Online: 15 February 2022 (09:20:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0085.v1

Ligand Docking Methods to Recognize Allosteric Inhibitors for G-protein Coupled Receptors

K Harini, S Jayashree, Vikas Tiwari, Sneha Vishwanath, Ramanathan Sowdhamini

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: allosteric ligands; AutoDock; cognate ligands; Tanimoto co-efficient; GPCRs

Online: 3 December 2020 (13:08:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0009.v1

Network Biology Analyses and Dynamic Modeling of Gene Regulatory Networks Under Drought Stress Reveal Major Transcriptional Regulators in Arabidopsis

Nilesh Kumar, Bharat Kumar Mishra, Jinbao Liu, Binoop Mohan, Karolina Marta Pajerowska-Mukhtar, M. Shahid Mukhtar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: co-expression network, water deprivation, drought, systems biology, network centrality, computational simulation, Arabidopsis, transcriptional regulation

Online: 1 July 2022 (08:15:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0608.v1

A Comparative Analysis of Co-Production in Public Services

Pwint Kay Khine, Jianing Mi, Raza Shahid

Subject: Business, Economics And Management, Accounting And Taxation Keywords: co-production; knowledge production; public services

Online: 22 April 2021 (13:23:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0298.v1

Effect of the Incorporation of Titanium on the Optical Properties of ZnO Thin Films: From Doping to Mixed Oxide Formation

Miriam Yuste, Ramon Escobar-Galindo, Noelia Benito, Carlos Palacio, Oscar Martinez, Jose Maria Albella, Olga Sánchez

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Ti doped ZnO, Thin film, Co-Sputtering, UV-Visible

Online: 25 December 2018 (08:40:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0480.v1

The Effects of Myrothecium verrucaria (MV) on Corn Stover During Co-Composting Process Under Room Temperature Conditions

Gabriel Akwakwa Hopla, Ming Yue Yao, GuoZhu Lei, Onautshu Odimba, Gang Wang, Huan Chen, Sitong Zhang, Guang Chen, Chunyu Sun, Yang Sun

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Myrothecium verrucaria; lignocelluloses; Scanning electron microscope (SEM); Fourier transform infrared spectroscopy (FTIR); pretreatment; degradation; co-composting; corn stover; cow manure

Online: 18 June 2021 (13:06:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0284.v1

Production of Various Monomer-Ratio Biodegradable Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Films for Wide Range of Applications

Aneta Pospíšilová, Juraj Vodicka, Monika Trudicova, Zuzana Juglova, Jiri Smilek, Přemysl Menčík, Jiří Másilko, Eva Slaninova, Veronika Melčová, Michal Kalina, Stanislav Obruča, Petr Sedlacek

Subject: Chemistry And Materials Science, Biomaterials Keywords: Polyhydroxyalkanoates (PHA); P(3HB-co-4HB); Aneurinibacillus sp. H1; mechanical properties; surface morphology; crystallinity; active ingredients release

Online: 28 April 2022 (10:56:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0740.v1

Integration and Prototyping of a Pulsed Rf Oscillator with an Uwb Antenna for Low-Cost, Low-Power Rtls Applications.

Stefano Bottigliero, Riccardo Maggiora

Subject: Engineering, Automotive Engineering Keywords: Elliptical dipole antenna; EM/circuit co-simulation; Low-cost; Low-Power; RF oscillator; RTLS; Ultrawide band antennas; Power gating

Online: 30 June 2021 (16:00:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0711.v1

Exploring the Regulatory Potential of Long Non-Coding RNA in Feed Efficiency of Indicine Cattle

Pamela A. Alexandre, Antonio Reverter, Laercio R. Porto-Neto, Roberta B. Berezin, Gabriela Ribeiro, Miguel Henrique Almeida Santana, José Bento Sterman Ferraz, Heidge Fukumasu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: co-expression network; residual feed intake; RNA-Seq

Online: 30 July 2020 (09:39:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0041.v2

Reconstructing the 26 June 1917 Samoa Tsunami Disaster

Laura Sischka, Cyprien Bosserelle, Shaun Williams, Josephina Chan Ting, Ryan Paulik, Malcolm Whitworth, Lameko Talia, Paul Viskovic

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: coastal inundation; historical tsunami records; hazard exposure; impacts; BG-Flood; RiskScape

Online: 22 March 2022 (11:56:13 CET)

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The 26 June 1917 tsunamigenic earthquake in Samoa is considered the largest historical event on record to have impacted this region in terms of earthquake magnitude and intensity. Yet, very little is known about the scale and distribution of tsunami impacts compared with the recent 2009 event which originated about 150 km east along the subduction zone bend of the Northern Tonga Trench (NTT). In this study we set out to: 1) reconstruct the 1917 tsunami from source to inundation to understand its hazard risk characteristics in the Samoan islands of Savai’i and Upolu; and 2) assess the hazard implications of tsunamis sourced from different locations along the subduction zone bend of the NTT on present-day exposure of coastal assets relative to the 2009 tsunami benchmark. We use the BG-Flood numerical modelling suite to produce model outputs representing inundation extent and hazard depth intensities at spatially flexible grid resolution (10 m, 20 m and 40 m). These are validated using available tide gauge records in Apia harbour and limited observations of runup that were derived from historical records. We then combine the inundation model with available digital distributions of buildings in the RiskScape multi-hazard risk analysis software, to produce exposure metrics for understanding the likely impacts on present-day coastal asset and population distributions if a similar tsunami were to occur. Results of the tsunami modelling indicate variable modelled-to-observed consistency using available source models, wave and runup validation data. Discrepancies in recorded vs modelled wave arrival time at Apia of between 30—40 mins are observed, with modelled runup underestimated in southeast Upolu Island compared with the rest of the country where runup observations are available (e.g., Savai’i Island). These differences likely reflect complexities in the tsunami source mechanism which might not currently be represented in our modelling. Nevertheless, our results suggest that a larger proportion of people would be exposed in Savai’i island (71% of exposure total), compared with Upolu island if a characteristic 1917-type event were to occur. While this study provides the first detailed inundation model of the 1917 tsunami in the Samoan region, the observed discrepancies suggest that further investigation is required to constrain potential tsunami source complexities which might not be accounted for in this study. Notwithstanding these limitations, our findings help to reinforce an appreciation of the risk to the greater Samoan region faced by local tsunamis sourced at different locations along the subduction zone bend of the NTT.

Preprint ARTICLE | doi:10.20944/preprints202011.0566.v2

Self-Healing Biogeopolymers Using Biochar-Immobilized Spores of Pure- and Co-Cultures of Bacteria

Jadin Zam S. Doctolero, Arnel B. Beltran, Marigold O. Uba, April Anne S. Tigue, Michael Angelo B. Promentilla

Subject: Engineering, Architecture, Building And Construction Keywords: geopolymer; self-healing; crack repair; biomineralization; healing agent; ureolytic bacteria; non-ureolytic bacteria; co-cultured bacteria

Online: 30 November 2020 (11:03:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0051.v1

A Reality We Have to Face in the Era of Tenofovir-Derived Pre-exposure Prophylaxis and Antiretroviral Therapy: A Paradigm Shift From the Reduction of HIV Risk to the Increased Risk of Cardiovascular Disease?

Jason Lew, Ilias Yee

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Tenofovir; Pre-exposure prophylaxis; anti-retroviral therapy; cardiovascular disease; LGBT

Online: 5 May 2022 (16:11:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0308.v1

Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells

Najla Santos Pacheco de Campos, Adriano de Oliveira Beserra, Pedro Henrique Barbosa Pereira, Alexandre Silva Chaves, Fernando Luiz Affonso Fonseca, Tiago da Silva Medina, Tiago Goss dos Santos, Yufei Wang, Wayne Anthony Marasco, Eloah Rabello Suarez

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: adoptive T cell therapy; hypoxic tumors; immune checkpoint blockade; CAR T; solid tumors; T cell exhaustion; co-stimulatory domains; CD28; 4-1BB; CD137

Online: 29 April 2022 (15:14:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0586.v1

Co-digestion of Extended Aeration Sewage Sludge With Whey, Grease and Septage: Experimental and Modelling Determination

Gérard Merlin, Jonathan Outin, Hervé Boileau

Subject: Engineering, Automotive Engineering Keywords: Anaerobic co-digestion; ADM1; BMP; biogas

Online: 26 July 2021 (14:49:51 CEST)

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Working Paper ARTICLE

Collaborative Learning Experiences in a Changing Environment. Innovative Educational Approaches in Architecture

Ernesto Antonini, Jacopo Gaspari, Cristina Visconti

Subject: Social Sciences, Anthropology Keywords: critical pedagogy; experiential learning; co-production

Online: 5 July 2021 (10:35:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0471.v1

Bacterial Foraging Algorithm for Optimal Joint-Force Searching Strategy of Multi – SAR Vessels at Sea

Ngoc Ha Pham, Minh Duc Nguyen

Subject: Engineering, Marine Engineering Keywords: search and rescue; optimal search algorithm; BFOA; multi-direction search; co-ordinate SAR operations

Online: 31 March 2020 (23:26:00 CEST)

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