Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Tailored Biodegradable and Electroactive Poly(hydroxybutyrate-co-hydroxyvalerate) Based Morphologies for Tissue Engineering Applications

Luís Amaro
,
Daniela M. Correia
,
Teresa Marques-Almeida
,
Pedro M. Martins
ORCID logo ,
Leyre Pérez
,
Jose Luis Vilas
,
Gabriela Botelho
,
Senentxu Lanceros-Mendez
* ,
Clarisse Ribeiro
ORCID logo
Version 1 : Received: 30 June 2018 / Approved: 3 July 2018 / Online: 3 July 2018 (05:12:53 CEST)

A peer-reviewed article of this Preprint also exists.

Amaro, L.; Correia, D.M.; Marques-Almeida, T.; Martins, P.M.; Pérez, L.; Vilas, J.L.; Botelho, G.; Lanceros-Mendez, S.; Ribeiro, C. Tailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applications. Int. J. Mol. Sci. 2018, 19, 2149. Amaro, L.; Correia, D.M.; Marques-Almeida, T.; Martins, P.M.; Pérez, L.; Vilas, J.L.; Botelho, G.; Lanceros-Mendez, S.; Ribeiro, C. Tailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applications. Int. J. Mol. Sci. 2018, 19, 2149.

Abstract

Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Further, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable and piezoelectric biopolymer that has been processed in different morphologies, including films, fibres, microspheres and 3D scaffolds. Further, the corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic and mechanical properties of pristine and composites samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both, pristine and PHBV/cobalt ferrite composite samples are no cytotoxic, indicating their suitability for tissue engineering applications.

Keywords

biomaterials; cobalt ferrites; poly(hydroxybutyrate-co-hydroxyvalerate); tissue engineering

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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