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Preprint ARTICLE | doi:10.20944/preprints202311.0208.v1

Periodic Behavior of Selected Solar, Geomagnetic and Cosmic Activity Indices during Solar Cycle 24

Ali Kilcik, Atila Ozguc, Jean-Pierre Rozelot

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Solar cycles; Solar flares; Geomagnetic activity indices; Cosmic rays; Period analysis

Online: 3 November 2023 (11:23:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0851.v1

Effects of Low-Temperature Accumulation on Flowering of Prunus mume

Yuhan Zhang, Kaifeng Ma, Qingwei Li

Subject: Biology And Life Sciences, Horticulture Keywords: Prunus mume, low-temperature, flower period regulation, dormancy release, flowering characteristics

Online: 11 May 2023 (12:19:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0365.v1

Connecting the Dots Between Mental and Menstrual Health

Esther Ajari

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Menstruation; menstrual health; menstrual hygiene; period poverty; mental health; mental disorder

Online: 17 May 2021 (07:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0538.v1

Lepton Pair Production with Only One Charge Available - Neutrino

Ari Lehto

Subject: Physical Sciences, Particle And Field Physics Keywords: neutrino; period doubling; muon decay; elementary charge; electron mass; Planck units

Online: 26 January 2021 (12:16:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0659.v1

A Portable Fuzzy Sink Scheme for Wireless Sensor Network Life Expectancy Enhancement

WASSWA SHAFIK, S.Mojtaba Matinkhah

Subject: Engineering, Electrical And Electronic Engineering Keywords: Mobile sink; Network period; Funneling Effect; Wireless Sensor Network; Vitality Management.

Online: 27 July 2020 (07:59:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0151.v1

Climate Impacts on Capital Accumulation in a Small Island Developing State

Eric Kemp-Benedict, Jonathan Lamontagne, Timothy Laing, Crystal Drakes

Subject: Business, Economics And Management, Economics Keywords: climate change; adaptation; loss & damage; damage function; return period; tropical cyclone

Online: 13 May 2019 (10:07:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0005.v1

Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study

Sun-Joon Bai, Ki-Young Lee, Sung Soo Kim, Jung Hwa Hong, Hoon Jae Nam, Jae Chul Koh, Na Young Kim

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: anaesthesia, general; anaesthesia recovery period; single dose of rocuronium; sugammadex; neostigmine

Online: 8 November 2018 (14:00:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0625.v1

Exploitation of Biogas Resources for Electric Vehicle Charging Station in Bangladesh

Ashish Kumar Karmaker, Md. Mijanur Rahman, Md. Alamgir Hossain, Md. Raju Ahmed

Subject: Engineering, Energy And Fuel Technology Keywords: Electric vehicle charging station (EVCS), HOMER, MATLAB, CO2 emission, payback period

Online: 31 July 2018 (14:20:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0213.v2

High-Resolution Atmospheric Lead Pollution during the Roman Period Recorded in Belgian Ombrotrophic Peat Cores

Mohammed Allan, Daniele L. Pinti, Bassam Ghaleb, Sophie Verheyden, Nadine Mattielli, Nathalie Fagel

Subject: Environmental And Earth Sciences, Environmental Science Keywords: atmospheric pollution; Pb accumulation rate; peat geochemistry; Roman period; Pb isotopes

Online: 22 May 2018 (07:44:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0111.v1

Optimizing Age-Structured and Risk-Based Mass Drug Administration Against Soil-Transmitted Helminthiasis in Ghana Using Cost-Effectiveness Analysis

Mugdha Thakur, Rasheeda Mohammed, Anuj Mubayi

Subject: Computer Science And Mathematics, Analysis Keywords: helminthiasis dynamics in Ghana, preventive chemotherapy, school-aged children, high-risk adults, neglected tropical diseases, age-structure, infection risk, cost analysis

Online: 5 November 2018 (11:43:33 CET)

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Soil-transmitted helminthiasis (STH), a neglected tropical disease (NTD) remains a major health problem all over the world including Ghana, which has STH prevalence of 25.4%. To control the disease, the government of Ghana currently concentrates on implementing mass drug administration (MDA) efforts focusing only among school-aged children. However, various studies have suggested that focusing on only a specific group for MDA may not be cost-effective. Moreover, some adults such as teachers and school-workers spend large fraction of their time with children, who shed more parasite in environment due to unhygienic behavior, and thus have a higher risk of getting infected as compared to other adults. In this study we use a mathematical model to evaluate age-structured and risk-based policies for implementing MDA while capturing transmission dynamics of STH in Ghana. A cost model was developed that included various costs related to MDA to study cost-effectiveness of current policies of MDA in Ghana against novel policies to control STH in Ghana. We carry out analysis for five different scenarios— I: no MDA (baseline), II: current MDA policy (focusing children) in Ghana, III: MDA for different age groups (adults and children groups) for unlimited budget, IV: MDA for different age groups with limitations of number of individuals treated, and, V: MDA for different groups based on their risk of getting infected (adults school workers (high-risk group), adults non-school workers and children groups). Our results suggest that it might be more cost-effective to allocate treatment through MDA to at least some proportion of adults along with children. In case of unlimited budget, the best strategy in Scenario IV would be to treat approximately 22% of adults and approximately 45% of children. The most cost-effective among the 5 scenarios is suggested through scenario V, where high-risk adults group and children are provided MDA at higher level than low-risk adults. In conclusion, age-structured and risk-based allocation of treatment and resources is crucial to reducing STH load in developing countries.

Preprint ARTICLE | doi:10.20944/preprints202201.0152.v1

Residential Mobility of a Cohort of Homeless People in Times of Crisis: COVID-19 Pandemic in an European Metropolis

Agathe Allibert, Aurélie Tinland, Jordi Landier, Sandrine Loubière, Jean Gaudart, Marine Mosnier, Cyril Farnarier, Pascal Auquier, Emilie Mosnier

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: SARS-CoV2; COVID-19; homeless people; public health; vulnerable population; Seroprevalence, cohort; residential mobility

Online: 11 January 2022 (17:20:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0588.v1

Honors and Costs of Being Heroes: Risk Factors and Epidemiology of COVID-19 Infection among Health Care Workers of a Severely Hit COVID-19-Referral Hospital in Italy

Marta Colaneri, Viola Novelli, Sara Cutti, Alba Muzzi, Guido Resani, Cristina Monti, Claudia Rona, Anna Maria Grugnetti, Marco Rettani, Francesca Rovida, Valentina Zuccaro, Antonio Triarico, Carlo Marena

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: retrospective cohort study; COVID-19; SARS-CoV-2; health care workers; risk of infection

Online: 27 August 2020 (03:25:18 CEST)

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Working Paper ARTICLE

Objectives of Sustainable Development and Youth Employment in Colombia

Cristian Castillo, Julimar Da Silva, Sandro Monsueto

Subject: Business, Economics And Management, Economics Keywords: Sustainable Development Goals; Human Capital; youth unemployment; Probit model; multinomial logit model; cohort study

Online: 2 December 2019 (04:42:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2104.v1

A New Species of Hemilauxania Hennig (Lauxaniidae) from the Lower Eocene Oise Amber—The Oldest Record of Schizophora (Diptera)?

Jindřich Roháček, Christel Hoffeins

Subject: Biology And Life Sciences, Insect Science Keywords: extinct lauxaniid flies; age of Acalyptratae; Paleogene

Online: 29 September 2023 (10:57:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1739.v1

Effects of Age and Season on Blood Parameters of Domesticated Giant Pandas

Ruijie Jiang, Xinyi Zhang, Kai Fan, Maohua Xia, Sufen Zhao, Yunsheng Wang, Tianchun Pu, Chenglin Zhang, Zhong Wu, Haihong Xu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: giant pandas; seasonal; age; blood Indices; hemorheology

Online: 24 August 2023 (10:10:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2052.v1

Artificial Intelligence Prediction of Gestational Age of Fetal in Brain Magnetic Resonance Imaging versus ultrasound Using three different Biometric Measurements

Farzan Vahedifard, Xuchu Liu, Kranthi K. Marathu, Mehmet Kocak, H. Asher Ai, Mark P. Supanich, Seth Adler, Shehbaz M. Ansari, Melih Akyuz, Jubril O. Adepoju, Sharon Byrd

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Artificial Intelligence; Gestational Age; Fetal Brain; MRI

Online: 31 July 2023 (03:07:23 CEST)

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Abstract: Accurately predicting a fetus's gestational age (GA) is of utmost importance in prenatal care. This study aimed to develop an artificial intelligence (AI) model that can automatically predict GA using biometric measurements derived from fetal brain mag-netic resonance imaging (MRI). Additionally, we aimed to assess the significance of con-sidering different references when interpreting GA predictions. To achieve this, we obtained measurements such as Biparietal Diameter (BPD), Fron-to-occipital Diameter (FOD), and Head Circumference (HC) from a dataset comprising 52 normal fetal MRI cases with T2 Haste sequences from Rush University. Both manual and AI-based methods were utilized to acquire these measurements. We also employed three reference papers (Garel, Freq, and Bio) for comparison purposes. The results demonstrated a strong correlation between manual and AI measure-ments, indicating consistency between the two methods. The AI-based measurement of HC exhibited a higher correlation with actual values compared to BPD, FOD, and correct-ed BPD (BPDC). When comparing these measurements with GA in the Picture Archiving and Communication System (PACS), the differences varied depending on the reference used. Specifically, the differences ranged from 0.47 to 2.17 weeks for BPD, 0.46 to 2.26 weeks for FOD, and 0.75 to 1.74 weeks for HC. Furthermore, the Pearson correlation coeffi-cient analysis revealed that all correlation coefficients between PACS records and GA pre-dictions using different references were greater than 0.97. In conclusion, the AI model based on fetal brain MRI accurately predicts GA by uti-lizing BPD, FOD, and HC measurements. The AI approach, which involves combining line segments to calculate fetal head circumference, offers improved accuracy and con-venience compared to manual estimation. This study underscores the potential of AI models in accurately estimating gestational age and highlights their utility in prenatal care. By integrating AI as a valuable tool in prenatal care, we can enhance the accuracy, ef-ficiency, and decision-making involved in assessing fetal development and monitoring pregnancies using MRI measurements.

Preprint ARTICLE | doi:10.20944/preprints202305.1956.v1

Characteristics of Mental Toughness in Young Basketball Players of Different Age Groups

Eimantas Pocius, Romualdas Malinauskas

Subject: Social Sciences, Psychology Keywords: mental toughness skills; young athletes; age groups

Online: 29 May 2023 (04:04:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0685.v1

Association of Metabolic Syndrome Components with Kidney Cancer in Young Adult Population : A Nationwide Population-Based Cohort Study in Korea

Hee Yeon Lee, Kyung-Do Han, In Sook Woo, Hyuk-Sang Kwon

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Kidney cancer; Metabolic syndrome; Age; Young adults

Online: 10 May 2023 (04:38:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0019.v1

Glacier Recession in Altay Mountains after the LIA Maximum

Dmitry Ganyushkin, Kirill Chistyakov, Ekaterina Derkach, Dmitriy Bantcev, Elena Kunaeva, Anton Terekhov, Valeriia Rasputina

Subject: Environmental And Earth Sciences, Environmental Science Keywords: glaciers; Little Ice Age; reconstruction; retreat; Altai

Online: 4 January 2022 (20:30:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0210.v1

Metabolomic Characterization of Olive Xylem Sap Reveals Differences According to Plant Age and Genotype

Manuel Anguita-Maeso, Carmen Haro, Miguel Montes-Borrego, Leonardo De La Fuente, Juan A. Navas-Cortés, Blanca B. Landa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: olive; xylem sap; metabolomics; plant age; genotype

Online: 8 March 2021 (10:56:37 CET)

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Vascular pathogens are the causal agents of main diseases threatening the health and growth of olive crops worldwide. The use of endophytic microorganisms represents a challenging and promising strategy for management of vascular diseases in olive. Although current research has been focused on analyzing the structure and diversity of the endophytic microbial communities inhabiting the olive xylem, the characterization of this ecological niche has been overlooked and to date remain unexplored, despite that the characterization of the xylem sap composition is essential to unravel the nutritional requirements of xylem-limited microorganisms. In this study, branches from plantlets and adult olive trees of cultivars ‘Picual’ and ‘Arbequina' were selected to characterize the chemical composition of olive xylem sap extracted using a Scholander pressure chamber. Metabolome and ionome analyses of xylem sap were performed by proton nuclear magnetic resonance (NMR) spectroscopy-based and by inductively coupled plasma with optical emission spectroscopy (ICP-OES), respectively. Olive xylem sap metabolites included a higher relative percentage of sugars (54.35%), followed by alcohols (28.85%), amino acids (8.01%), organic acids (7.68%) and osmolytes (1.12%). Within each of these groups, the main metabolites in the olive xylem sap were mannitol, ethanol, glutamine, acetate and trigonelline, whereas K and Cl- were the main element and inorganic anion, respectively. Metabolomic profile varied when comparing olive plant age and genotype. The levels of glucose, fructose, sucrose and mannitol, choline, B and PO43 were significantly higher in adult trees than in plantlets for both olive genotypes, whereas NO3- and Rb content showed the opposite behavior. On the other hand, levels of aspartate, phenylalanine and Na were significantly higher in ‘Picual’ than in ‘Arbequina’ whereas Fe showed the opposite behavior but only for adult trees. Non-supervised hierarchical clustering analysis separated xylem sap composition firstly according to the plant age and then by the olive cultivar. Supervised PLS-DA analysis revealed that B, ethanol, Fe, Fructose, glucose, mannitol, sucrose and Sr were the most significative compounds discriminating adult trees from plantlets, whereas asparagine, aspartate, glutamate and phenylalanine or aspartate, arginine, ethanol and Sr were the most contributory compounds in the discrimination of both olive genotypes for adult trees or plantlets, respectively. Knowledge of the chemical composition of xylem sap will lead to a better understanding of the complex nutritional requirements of olive xylem-inhabiting microorganisms, including its vascular pathogens, and would allow the design of artificial growing media to improve culturing the olive microbiome.

Preprint ARTICLE | doi:10.20944/preprints201808.0025.v1

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways

Georg Fuellen, Ludger Jansen, Alan A. Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal, Rüdiger Köhling, Steffen Möller

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: terminology, health, aging, biological age, wellbeing, biomarker

Online: 1 August 2018 (15:00:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1811.v1

A Weighted kNN Based Spatial Framework of Flood Inundation Risk for Coastal Tourism – A Case Study in Zhejiang, China

Shuang Liu, Nengzhi Tan, Rui Liu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: climate change; sensitivity analysis; evaluation accuracy; hazard; year return period; overall accuracy

Online: 28 August 2023 (03:43:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1383.v1

Investigating the Effectiveness of Mindfulness-Based Stress Reduction on Mental Health, Mindfulness, and Sleep Quality in Post COVID Period

Mansooreh Azizzadeh Forouzi, Fahimeh Baghbani, Azam Zare Arashlouei, Abolfazl Hossein Nataj, Malihe Pooredalati, Fatemeh Khajooi, Elham Pourafrouz, Atefeh Ahmadi, Vahideh Arabfaridy

Subject: Public Health And Healthcare, Primary Health Care Keywords: Mindfulness based stress reduction; mental health; mindfulness; sleep quality; post COVID period

Online: 20 July 2023 (05:16:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0349.v2

Cost Implications of Menstrual Hygiene Management in Nigeria and Its Associated Impacts

Esther Ajari, Temidayo Abass, Esther Ilesanmi, Yusuff Adebisi

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Menstrual Hygiene Management; Menstrual pads; Menstruation; Nigeria; Period poverty; Sustainable Development Goals

Online: 20 September 2021 (10:37:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0599.v2

Clinical Experience with the Fifth-Generation of a Breast Implant with a Smooth, Fine Surface from a Korean Manufacturer in Asian Women

Dong Yeon Hwang, Sang Wha Kim, Joon Yong Jung

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Clinical Study; Retrospective Studies; Surgical Procedures, Operative; Postoperative Period; Follow-Up Studies.

Online: 28 July 2021 (16:56:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0355.v1

The Seneb´S EnigmA: Impact of a Hybrid Personal and Social Re-Sponsibility and Gamification Model-Based Practice on Motivation and Healthy Habits in Physical Education

David Melero-Canas, David Manzano-Sánchez, Daniel Navarro-Ardoy, Vicente Morales-Baños, Alfonso Valero-Valenzuela

Subject: Business, Economics And Management, Accounting And Taxation Keywords: physical activity; self-determination theory; after-school period; physical fitness; sedentary time

Online: 18 January 2021 (15:11:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0268.v1

Composition and Genetic Diversity of the Nicotiana tabacum Microbiome in Different Topographic Areas and Growth Periods

Xiaolong Yuan, Xinmin Liu, Yongmei Du, Guoming Shen, Zhongfeng Zhang, Jinhai Li, Peng Zhang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Nicotiana tabacum; Topographic; Growth period; Fungal community composition; Genetic Diversity; ITS1 region

Online: 15 August 2018 (10:51:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0127.v1

Correlation of Cataract Prevalence according to Ultraviolet Amount in Korean Adults

Hee-Jeong Jang, Joong-Gu Kang

Subject: Health Policy And Services, Public Health And Healthcare Keywords: Cataracts; sunlight exposure time; gender; age; education; residence

Online: 2 May 2024 (10:12:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1771.v1

Evidence of Age Estimation Procedures in Forensic Dentistry: Results from an Umbrella Review

João Albernaz Neves, Luísa Bandeira Lopes, Vanessa Machado, João Botelho, Ana Delgado, José João Mendes

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: forensic dentistry; age estimation; dental maturation; umbrella review

Online: 27 October 2023 (09:26:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1105.v1

MethylRAD-Seq Technology Reveals DNA Methylation Charac-Teristics of Apostichopus japonicus of Different Ages

Xinyu Yang, Lingshu Han, Qi Ye, Hao Wang, Jinyuan Zhang, Wenpei Wang, HaoRan Xiao, Yongjie Wang, Luo Wang, Jun Ding

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: MethylRAD-Seq; A. japonicus; body wall; age identification

Online: 18 October 2023 (08:21:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0990.v1

Lipid Profile in Children Born Small for Gestational Age

Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Beata Kierzkowska, Marta Gruca, Agnieszka Wosiak, Elżbieta Smolewska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: children; lipid profile; cholesterol; small for gestational age

Online: 14 September 2023 (14:05:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0524.v1

From Immunosenescence to Aging Types – Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation

Peter Bröde, Maren Claus, Patrick D Gajewski, Stephan Getzmann, Edmund Wascher, Carsten Watzl

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immunosenescence; biological age; biomarker; flow cytometry; longitudinal study

Online: 7 August 2023 (10:05:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1115.v1

A Paradigm Shift in the Entertainment Industry in the Digital Age: A Critical Review

Dr. Bharat Dhiman

Subject: Arts And Humanities, Film, Radio And Television Keywords: media; digital media; entertainment; paradigm shift; digital age

Online: 15 June 2023 (09:40:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0738.v1

Effects of Physical Activity Program on Body Composition, Physical Performance, and Neuromuscular Strategies During Walking in Older Adults With Sarcopenic Obesity: Randomized Controlled Trial

Hamza FERHI, Sabri GAIED CHORTANE, Sylvain DURAND, Bruno BEAUNE, Sebastien BOYAS, Wael MAKTOUF

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: age; obesity; gait; physical activity; neuromuscular system; sarcopenia

Online: 12 June 2023 (03:02:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2151.v1

A Class of Models That Support a Maximum Entropy Principle for Age Structure

Henri Laurie

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Population dynamics; age structure; entropy; Maximum Entropy Principle

Online: 30 May 2023 (13:20:58 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202107.0075.v1

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A Zoller, Steve Horvath, Lori H Schwacke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Online: 5 July 2021 (07:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0200.v1

Comparison of Gender, Age, and Body Mass Index Levels for Spatiotemporal Parameters of Bilateral Gait Pattern

Turki S. Abualait, Mohammad Ahsan

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: spatiotemporal parameters; gait; gender; age; Body Mass Index

Online: 9 September 2020 (07:12:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0367.v1

Epidemiological Characteristics of Early COVID-19 Case Outbreaks in Indonesia

Abu Bakar, Triyono Indrasiwi Kuncoroaji, Andy Lee, Shih-Chieh Lee, Valendriyani Ningrum

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Confirmed cases, case fatality rate, province, age, gender.

Online: 17 July 2020 (06:24:55 CEST)

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The initial outbreak of COVID-19 was first reported in Wuhan (China) during the latter part of December 2019. Indonesia has the fourth-largest population globally and reported the country’s first case of the virus on 2nd March 2020. The World Health Organisation (WHO) in addition to several neighbouring provinces and educational institutions within the region began questioning the Indonesian government upon the initial case reported. The objective of this study was to describe the epidemiological characteristics of the COVID-19 outbreak in Indonesia during March 2020. The data were collected from Indonesian government databases and non-government organisations (NGOs). The data were analysed using Microsoft Office 2019 (Excel) and Adobe Illustrator 2017 software, was used in drawing the map depicting the distribution of COVID-19 in Indonesia. As at 31st March 2020, a total of 1,528 people in Indonesia have been infected by COVID-19, in addition to 136 mortalities (CFR of 8.9%). Jakarta, as the principal capital of Indonesia, quickly has become the epicentre of the virus since this period. Most patient cases were attributed to those aged between 31 and 70 years (72.64%), with male patients (64.93%) representing the highest incidence of cases compared to female patients (35.07%). The number of ventilating machines was 3,326, with hospital numbers at 859. The distribution of cases depicting COVID-19 was mainly seen in urban areas compared to rural areas. Males compared to females, are at a higher risk of contracting COVID-19, including those aged below 30, between 30 and 60 or above. Indonesia also has the highest case fatality rate (CFR) with respect to mortalities in Southeast Asia and has the second-highest CFR globally. Similarly, while the number of ventilator machines as at 31st March 2020 were sufficient in meeting the growing number of COVID-19 cases in the country, it is possible that the government may need to increase the number of ventilators if the cases continue to escalate.

Preprint ARTICLE | doi:10.20944/preprints201911.0335.v1

Socio-Moral Development of Preschool Children: Aspects of Theory and Practice

Evgenia Korotaeva, Irina Chugaeva

Subject: Social Sciences, Psychology Keywords: social and moral education; preschool age; communitarian approach

Online: 27 November 2019 (08:46:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0106.v1

Comparative Assessment of Age, Growth and Food Habit of the Black-Chinned Tilapia, Sarotherodon melanotheron (Rüppell, 1852), from Closed and Open Lagoons, Ghana

Cephas Kwesi Zuh, Seth Mensah Abobi, Benjamin Betey Campion

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Ghana; lagoon; tilapia; fish growth; otoliths; age; food

Online: 12 February 2019 (17:14:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0122.v1

Spatial and Age Related Effects on Phytochemical Compounds of Ethanolic Extract of Gigantochloa scortechinii Rhizome

Johar Mohamed, Hazandy Abdul Hamid, Ahmad Ainuddin Nuruddin, Nik Muhammad Nik Abdul Majid

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: spatial; age-related; phytochemical; bamboo; rhizome; GC-MS

Online: 7 September 2018 (03:01:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0137.v1

Gimbutas’ Smile – An Archaeology Led, Archaeogenetic Model

Bob Kenyon

Subject: Arts And Humanities, Archaeology Keywords: Archaeology; Archaeogenetic Model; Neolithic; Chalcolithic; Bronze Age; Migration

Online: 19 December 2017 (15:49:22 CET)

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Migrations are much more important than currently recognised, for explaining important patterns observed in the European archaeology record – according to this archaeology led model. At a high level, they explain the introduction of different farming, monument building, the spread of metalworking and patterns of trade and exchange. This paper presents an archaeogenetic model based on a strategic review of the Neolithic and Chalcolithic archaeology of Europe, alongside a review of recently published ancient DNA data. The model is archaeology led. It takes archaeology themes and proposes migratory events to explain them. Ancient DNA data and further archaeology evidence is then used to test these proposed migrations- to reject or refine them. The model introduces a new and more strategic way of looking at archaeological cultures - that updates early 20th century approaches to studying archaeology cultures, and integrates with the detailed ‘post processual’ studies of the late 20th Century. The model consists of seven maps – each showing multiple migration events – with key evidence to support each migration map. It proposes a new category of a ‘Black Sea’ related population that makes a major genetic contribution to the Middle Neolithic of Europe. The proposed migrations provide an explanation for the observed patterns of archaeology, for example: • multiple Neolithic migrations that introduced, farming and metalworking into Europe; • a major ‘Black Sea’ related ‘Middle Neolithic’ migration that carried advanced knowledge of astronomy that can be recognised in a variety of types of monument from the Neolithic through to Bronze Age Europe; and, • migrations of related cultures (‘supercultures’) that explain patterns of trade and exchange in Bronze Age western Europe. The model also provides ancient DNA and archaeology based support for the key aspects of Childe’s ‘dawn of civilisation’ in Europe and Egypt and Gimbutas’ ‘Old Europe’ and “three waves of migration from the Steppe”.

Preprint ARTICLE | doi:10.20944/preprints201709.0016.v1

Responses of Soil Microbial Communities to Robinia Pseudoacacia Plantations of Different Ages in A Loess Area

Bingxue Zhang, Rumeng Zhao, Boyuan Bi, Fengpeng Han

Subject: Biology And Life Sciences, Forestry Keywords: soil; Robinia pseudoacacia; PLFA; stand age; microbial community

Online: 5 September 2017 (15:28:05 CEST)

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Phospholipid fatty acids (PLFAs) can be used as biomarkers for qualitative and quantitative analyses of soil microbial community diversity. In this study, we collected soil samples at 10-cm intervals to a depth of 1 m from Robinia pseudoacacia plantations of four different ages (10, 15, 25 and 40 years) in a loess area and analysed the soil microbial community structure by PLFA analysis. A total of 97 PLFAs were detected in soils of R. pseudoacacia plantations of different ages. The individual PLFA contents gradually decreased in the 0- to 40-cm soil layers, with little variation in the 40- to 100-cm soil layers. The individual PLFAs were similarly distributed in the soils of R. pseudoacacia plantations of different ages, and there was a clear variation with stand age and soil depth. The individual PLFA contents in the 0- to 20-cm soil layers were highest for the 25-year-old plantation, while those in the 20- to 40-cm soil layers were relatively high for the 25- and 40-year-old plantations; the 16:0 content was the highest among individual PLFAs. The total PLFA content and the PLFA contents of different microbial groups [bacteria, fungi, Gram-positive bacteria (G⁺), Gram-negative bacteria (G^-) and actinomycetes] initially increased before decreasing in the soils of R. pseudoacacia plantations with increasing stand age, whereas these contents gradually decreased with increasing soil depth; the highest PLFA contents was found in the 25-year-old plantation. The total PLFA content and the contents of fungal, G^- and actinomycete PLFAs in the soils of R. pseudoacacia plantations differed significantly among stands of different ages in the 0- to 10-cm, 10- to 20-cm and 30- to 40-cm soil layers, while no significant differences were found in the 20- to 30-cm soil layers; the G⁺ and bacterial PLFAs contents in each of the 0- to 40-cm soil layers were significantly different. The PLFA ratios between different microbial groups differed among the stands of different ages. The fungi/bacteria ratio showed a “decrease-increase-decrease” trend with stand age, while the G⁺/G^- ratio showed an “increase-decrease” trend. The saturated/monounsaturated PLFA ratio initially decreased before plateauing, while the opposite trend was observed for the cyclopropyl/precursor ratio. The PLFA contents of different microbial groups were ranked as follows: bacteria > G^- > G⁺ > actinomycetes > fungi. In the principle component analysis, 18:1ω9c, 10Me18:0, i17:0, a17:0, 18:1ω7c, 18:1ω5c and 18:0 made the greatest contribution to principal component 1, and a14:0, i14:0 3OH, i14:0, i14:1ω7c and 14:0 made the greatest contribution to principal component 2. In conclusion, soil nutrient status and other soil eco-environmental stress factors should be considered in 10- to 25-year-old (particularly ~15-year-old) plots for the management of R. pseudoacacia plantations to prevent forest soil degradation and improve forest stand quality, thereby achieving better soil and water conservation and environmental improvement in R. pseudoacacia plantations.

Preprint ARTICLE | doi:10.20944/preprints202310.1033.v1

Dual-Period Polarization-Dependent Diffraction Gratings Based on a Polymer-Stabilized Liquid Crystal

Marta Kajkowska, Miłosz Chychłowski, Sławomir Ertman, Piotr Lesiak

Subject: Physical Sciences, Optics And Photonics Keywords: liquid crystal, polymer, polymer-stabilized liquid crystal, dual-period diffraction grating, polariza-tion

Online: 17 October 2023 (09:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1762.v1

Serum Metabolic Characterization of Vitamin E Deficiency in Holstein Cows During the Transition Period Based on Proton Nuclear Magnetic Resonance Spectroscopy

Yuxi Song, Hongyu Wang, Rui Sun, Jinshui Chang, Jipeng Tang, Yunlong Bai, Cheng Xia

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: dairy cows; transition period; vitamin E deficiency; serum; 1H nuclear magnetic resonance; metabolomics

Online: 26 July 2023 (07:29:11 CEST)

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Vitamin E, a potent antioxidant, is a necessary and complex micronutrient for cows. During the transition period, vitamin E deficiency (VED) is among the highest prevalent micronutrient deficits in dairy cows. It may eventually result in oxidative stress and immunological malfunction, and it increases the risk of peripartum disorders. At present, detailed data on blood metabolites in VED cows are limited. Consequently, the purpose of this research was to examine the alterations in the serum metabolic profile of VED cows throughout the early postpartum period. Using comprehensive 1H nuclear magnetic resonance (1H NMR), the alterations in serum metabolic activities of VED cows were analyzed. In total, 28 multiparous Holstein cows were assigned according to serum α-tocopherol (α-Toc) concentrations into a normal (α-Toc ≥ 4 μg/mL, n = 14) and VED (α-Toc < 3 μg/mL, n = 14) groups at 21 days postpartum, and their blood samples were collected for biochemical and 1H NMR analyses. A t-test on independent samples as well as multivariate statistics were used to assess the findings. In comparison with normal cows, VED cows showed significantly worse body condition scores, milk yield, and dry matter intake (p < 0.05). Significantly higher levels of serum non-esterified fatty acids, aspartate aminotransferase, low-density lipoprotein, and malonaldehyde were found in VED-affected cows, as well as lesser concentrations of serum albumin, high-density lipoprotein, and total antioxidant capacity in comparison with normal cows (p < 0.01), while other vitamins and minerals concentrations showed no distinction between the groups (p > 0.05). Furthermore, 24 upregulated serum metabolites were identified under VED conditions. The metabolomics pathway analysis of these metabolites demonstrated that a global metabolic response to VED in cows was represented by changes in 11 metabolic pathways, comprising energy, carbohydrate, and amino acid metabolism. These outcomes suggest that VED cows were more likely to experience a negative energy balance characterized by alterations of common systemic metabolic processes and develop oxidative stress, inflammation, and ultimately liver injury. This study provides the first evidence of metabolic changes in cows with VED.

Preprint ARTICLE | doi:10.20944/preprints202305.0916.v1

Heat Requirements of Prunus mume Cultivars for Flowering

Yuhan Zhang, Kaifeng Ma, Qingwei Li

Subject: Biology And Life Sciences, Horticulture Keywords: Prunus mume; regulation of flowering period; heat requirements; dormancy release; flower bud germination

Online: 12 May 2023 (09:49:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0319.v1

Improving Altimeter Wind Speed Retrievals Using Ocean Wave Parameters

Haoyu Jiang, Hao Zheng, Lin Mu

Subject: Environmental And Earth Sciences, Oceanography Keywords: altimeter; sea surface wind speed; significant wave height; mean wave period; atmospheric instability

Online: 23 February 2020 (11:09:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0174.v1

Wave Steepness from Satellite Altimetry for Wave Dynamics and Climate Studies

Sergei I. Badulin, Vika G. Grigorieva, Alexander V. Gavrikov, Vladimir V. Geogjaev, Mikhail V. Krinitskiy, Margarita Yu. Markina

Subject: Environmental And Earth Sciences, Oceanography Keywords: wave turbulence; satellite altimetry; wave steepness; parametric and physical models of wave period

Online: 25 December 2017 (09:06:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0237.v1

Erythrocyte n-6 Fatty Acids and Risk for Cardiovascular Outcomes and Total Mortality in the Framingham Heart Study

William S. Harris, Nathan L. Tintle, Ramachandran S. Vasan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: epidemiology; prospective cohort study; n-6 fatty acids; n-3 fatty acids; linoleic acid; arachidonic acid

Online: 9 November 2018 (04:07:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1085.v1

Preparation and hydration properties of sodium silicate-activated municipal solid waste incineration bottom ash composite slag cementitious materials

Juan Deng, Guoxiong Wu, Yuchao Xia, Li Liu

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: MSWIBA, sodium silicate-activated, hydration properties, equivalent age modeling

Online: 17 April 2024 (08:06:01 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.1332.v1

Influence of the Age of Free-Living Amoeba Cysts on Their Vertical Distribution in a Water Column

Zineb Fechtali-Moute, Sébastien Pomel

Subject: Biology And Life Sciences, Life Sciences Keywords: Free-Living Amoeba; cyst; age; water column; vertical distribution

Online: 17 January 2024 (13:38:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0166.v1

Knowledge Representation of Age-Related Diseases under Innate and Adaptative-Immunosenescence Valued Contexts

javier Burgos-Salcedo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Immunosenescence; Knowledge representation; Formal concept Analysis; Age-related diseases

Online: 4 December 2023 (11:27:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1534.v1

Mitigating Age-related Bias in Predictive Policing Algorithms

Ahmed Saud Almasoud

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: predictive policing; algorithms; fairness; age bias; strategic subject list

Online: 24 November 2023 (02:42:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1581.v1

Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily

Miriam Carella, Annamaria Porreca, Cinzia Piazza, Francesco Gervasi, Daniele Magro, Marika Venezia, Raffaella Lo verso, Giuseppe Vitale, Anna giusy Agnello, Tommaso Aronica, Carmela Rita Balistreri

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: renal age-related decline; kidney disease (KD); eGFR; mGPS

Online: 25 October 2023 (08:35:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1249.v1

The Relationship between Jealousy and Mate Retention Strategies in Romantic Relationships among Women during the COVID-19 Pandemic

Paulina Degiuli, Lea Andreis, Dario Vučenović

Subject: Social Sciences, Psychology Keywords: jealousy; partner retention strategies; romantic relationship; age; relationship length

Online: 20 October 2023 (08:06:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0658.v2

Assessment of Knowledge and Attitude of Reproductive Age Women towards Cervical Cancer Prevention in Selected Tertiary Institutions in Osun State, Nigeria

Oluwabunmi B. Erinsakin, Adeyemi O. Omoge, Oladunni Opeyemi, Idowu A. Olumakinde, Busayomi E. Folashayo, Michael N. Philip

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Knowledge; Attitude; Women of Reproductive Age; Cervical Cancer Prevention

Online: 17 October 2023 (11:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1322.v1

Age and Task Modulate Olfactory Sensitivity in the Florida Carpenter Ant Camponotus floridanus

Stephen T Ferguson, Isaac Bakis, Nicholas D Edwards, Laurence J Zwiebel

Subject: Biology And Life Sciences, Insect Science Keywords: hymenoptera; olfaction; odor coding; task allocation; age polyethism; aging

Online: 19 July 2023 (10:03:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0832.v1

Age of Onset Moderates the Association Between Total Antioxi-Dant Capacity and Cognitive Deficits in Patients With Drug-Naïve Schizophrenia

Jiaxin Li, Deyang Li, Junru Guo, Dongmei Wang, Xiangyang Zhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; age of onset; TAOC; cognitive function; oxidative stress

Online: 24 April 2023 (06:22:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0350.v2

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

Laura García-Quintanilla, Lorena Rodríguez-Martínez, Enrique Bandín-Vilar, María Gil-Martinez, Miguel González-Barcia, Cristina Mondelo-García, Anxo Fernández-Ferreiro, Jesús Mateos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Proteomics, Age-related macular degeneration, inflammation, biomarker, oxidative stress.

Online: 21 November 2022 (02:35:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0278.v1

Association between Knowledge about Anemia, Food Consumption Behaviors, and Hematocrit Level among School-Age Children in Nakhon Si Thammarat Province, Thailand

Pastraporn Kaewpawong, Kiatkamjorn Kusol, Onuma Bunkarn, Sirigran Sutthisompohn

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: knowledge; food consumption behaviors; hematocrit level; school-age children

Online: 19 October 2022 (10:06:28 CEST)

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Anemia is a significant public health problem among children, especially school-age children because their body quickly produces red blood cells to provide sufficient blood volume with plasma expansion to maintain blood concentration. This research aimed to study the anemia situation, knowledge about anemia, food consumption behaviors, and the association between knowledge, food consumption behaviors, and hematocrit level among school-age children in primary school, in Thasala district, Nakhon Si Thammarat Province. This is a descriptive study among 408 students, Grades 4 to 6, aged 9-12 years. Research instruments included the demographic data of the children and their knowledge about anemia, food consumption behaviors, and hematocrit assessment. Data were analyzed using descriptive, Spearman’s rank correlation coefficient, and logistic regression statistics. The results revealed that 23.2% of the samples had anemia, whereas 22.22% had mild anemia and 0.98% had moderate anemia. The children knew about anemia, where the mean score was at a moderate level (Mean= 6.63; SD= 2.51) out of 10. The mean score on food consumption behaviors was in the moderate level (Mean= 17.49; SD= 3.68) out of 24. There were significantly positive correlations between the knowledge about anemia and the hematocrit level at a moderate level (r= 0.45, p< 0.001). Correlation analysis revealed moderate food consumption behaviors with the hematocrit level (r= 0.40, p< 0.001). When confirm with Logistic regression found that knowledge about anemia (OR = 9.15, 95% CI: 4.57-18.34), and food consumption behaviors (OR = 19.09, 95% CI: 9.71-37.53) were significantly associated with the hematocrit level. Conclusions: This study showed that knowledge and appropriate food consumption behaviors are associated with hematocrit levels. Enhancing knowledge about anemia and food consumption behaviors may be reduced the prevalence of anemia in school-age children. The health care providers in primary care should be encouraged children to have health education and eat sufficient food.

Preprint ARTICLE | doi:10.20944/preprints202206.0091.v1

Assessing the Effectiveness of Tobacco 21 Laws to Reduce Underage Access to Tobacco: Protocol for a Repeated Multi-Site Study

Mary Hrywna, Amanda Kong, Christopher Ackerman, Shawna Hudson, Cristine Delnevo

Subject: Public Health And Healthcare, Health Policy And Services Keywords: tobacco age of sale; tobacco policy; youth; young adults

Online: 7 June 2022 (03:44:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0367.v1

Differences in Citation Patterns across Areas, Article Types and Age Groups of Researchers

Marcelo Mendoza

Subject: Social Sciences, Library And Information Sciences Keywords: Citation patterns; Age groups of researchers; Types of publications.

Online: 17 August 2021 (15:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0729.v1

Sergey Sudakov, Elena Alekseeva, Galina Nazarova, Valentina Bashkatova

Subject: Social Sciences, Psychology Keywords: age; behaviour; open field; physical activity; anxiety; Wistar rat.

Online: 30 June 2021 (10:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0536.v1

“What a Mobility-Limited World”: Design Requirements of an Age-Friendly Playable City

Liliana Vale Costa, Ana Isabel Veloso, Michael Loizou, Sylvester Arnab, Richard Tomlins, Arun Sukumar

Subject: Social Sciences, Urban Studies And Planning Keywords: playable city; age-friendly environments; games; mobility; active ageing

Online: 23 October 2018 (10:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0111.v1

Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations

Jacqueline R. Halladay, Kaitlin C. Lenhart, Kimberly Robasky, Wendell Jones, Wayne F. Homan, Doyle M. Cummings, Crystal W. Cené, Alan L. Hinderliter, Cassandra L. Miller, Katrina E. Donahue, Beverly A. Garcia, Thomas C. Keyserling, Alice S. Ammerman, Cam Patterson, Darren A. DeWalt, Larry F. Johnston, Monte S. Willis, Jonathan C. Schisler

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: hypertension; GWAS; precision medicine; rural population; SNP-age interaction

Online: 12 January 2018 (07:34:37 CET)

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Background: As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: i) determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure variation, identified in large case-control studies, are applicable to blood pressure control in subjects from a rural population; ii) measure the association of these SNPs with subjects’ responsiveness to the hypertension intervention; and iii) identify other SNPs that may help understand patient-specific responses to an intervention. Methods and Results: We used a combination of candidate SNPs and genome-wide analyses to test associations with either baseline systolic blood pressure (SBP) or change in systolic blood pressure one year after the intervention in two genetically defined ancestral groups: African Americans (AA) or Caucasian Americans (CAU). Of the 48 candidate SNPs, 13 SNPs associated with baseline SBP in our study; however, one candidate SNP, rs592582, also associated with a change in SBP after one year. Using our study data, we identified 4 and 15 additional loci that associated with a change in SBP in the AA and CAU groups, respectively. Our analysis of gene-age interactions identified genotypes associated with SBP improvement within different age groups of our populations. Moreover, our integrative analysis identified AQP4-AS1 and PADI2 as genes whose expression levels may contribute to the pleiotropy of complex traits involved in cardiovascular health and blood pressure regulation in response to an intervention targeting hypertension. Conclusions: Identification of SNPs associated with the success of a hypertension treatment intervention suggests that genetic factors in combination with age may contribute to an individual’s success in lowering SBP. If these findings prove to be applicable to other populations, the use of this genetic variation in making patient-specific interventions may help providers with making decisions to improve patient outcomes. Further investigation is required to determine the role of this genetic variance with respect to the management of hypertension such that more precise treatment recommendations may be made in the future as part of personalized medicine.

Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0980.v1

Accuracy of Patient-Specific Implants in Virtually Planned Segmental Le Fort I Osteotomies

Reinald Kuehle, Mats Scheurer, Frederic Bouffleur, Jennifer Fuchs, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: orthognathic surgery; Le-Fort I osteotomy; segmental osteotomy; cohort studies; Spiral Cone-Beam Computed Tomography; maxilla; osteotomy

Online: 14 August 2023 (10:18:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0478.v1

You + ME Registry: A Research Platform to Facilitate Clinical and Therapeutic Discoveries in ME/CFS and Related Diseases

Allison Ramiller, Kathleen Mudie, Elle Seibert, Sadie Whittaker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Long COVID; data acquisition source; post-infectious; longitudinal cohort study; patient-powered

Online: 25 November 2021 (13:51:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0710.v1

Gut Microbiota Influences Plasmodium Falciparum Malaria Susceptibility

Aly Kodio, Drissa Coulibaly, Safiatou Doumbo, Salimata Konaté, Abdoulaye Kassoum Koné, Lamine Tall, Ahmed Konaté, Boureima Guindo, Coralie L’ollivier, Anthony Levasseur, Fadi Bittar, Ogobara K. Doumbo, Raoult Didier, Mahamadou A. Thera, Stéphane Ranque

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gut microbiota; Mycobiota; Bacteria; Fungi; Malaria; Plasmodium falciparum; 16S metagenomics; ITS metagenomics; Children; Cohort; Mali; Dogon country

Online: 31 May 2021 (08:25:57 CEST)

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The gut microbiota has recently been associated with susceptibility/resistance to malaria in animal models and humans, yet the impact of the gut microbiota on the risk of a malaria attack remains to be assessed. This study aims at assessing the influence of the gut microbiota on malaria attacks and Plasmodium parasitæmia in children living in a malaria-endemic area in Mali. Three hundred healthy children were included in a 16-months cohort study in Bandiagara. Their gut bacteria and fungi community structures were characterised via 16S and ITS metabarcoding from stool samples collected at inclusion. Clinician team monitored the occurrence of malaria attacks. Asymptomatic carriage of Plasmodium was assessed by qPCR. Over the 16-month period, 107 (36%) children experienced at least one occurrence of malaria attacks, and 82 (27%) at least one asymptomatic Plasmodium parasitæmia episode. A higher gut bacteria richness was independently associated with susceptibility to asymptomatic parasitæmia episodes and malaria attacks; while the Shannon H diversity and Chao-1 richness index of gut fungi community structure was relatively homogeneous in children who were and were not infected with P. falciparum. Using a linear discriminant effect size analysis of operational taxonomic units assigned to the species level, 17 bacteria, including Clostridiaceae, Eubacteriaceae, Senegalimassilia sp., Atopobiaceae and Lachnosipraceae, and seven fungi, including Dioszegia fristigensis, Ogataea polymorpha and Cutaneotrichosporon cyanovorans, were associated with susceptibility; whereas eight bacteria, including, Bifidobacterium spp., Weissela confusa and Peptostreptococcacea, and 3 fungi, Malassezia sp., Niesslia exosporoides, and Didymocrea leucaenae, were associated with resistance to malaria. Moreover, 15 bacteria, including Coproccus eutactus, Terrisporobacter petrolearius, Klebsiella pneumoniae and Ruminococcaceae, and 13 fungi, including Wallemia mellicola, were associated with susceptibility, whereas 19 bacteria, including Bifidobacterium spp., Bacteroides fragilis, Peptostreptococcacea, and Lactobacillus ruminis, and three fungi, including Cryptococcus neoformans, were associated with resistance to asymptomatic Plasmodium parasitæmia episodes. Further studies are needed to confirm these findings that point the way towards strategies aiming to reduce the risk of malaria by modulating gut microbiota components in at-risk populations.

Preprint ARTICLE | doi:10.20944/preprints202311.0287.v1

Two Circumpolar Ground Beetle Species (Coleoptera: Carabidae) Were in Hokkaido, Japan in the Late Last Glacial Period

Shigehiko Shiyake

Subject: Biology And Life Sciences, Insect Science Keywords: Diacheila polita; Elaphrus lapponicus; ground beetles; forest tundra; fossil; Hokkaido; Last Glacial period; paleoenvironment

Online: 6 November 2023 (07:34:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0691.v1

Pediatric Postoperative Recovery—It’s Not Just about the Technology

Carina Sjöberg, Mona Ringdal, Pether Jildenstål

Subject: Public Health And Healthcare, Nursing Keywords: Apnea; Competence Clinical; Clinical Skills; Hypoventilation; Monitoring; Patient safety Pediatrics; Postoperative period; Vital signs

Online: 11 October 2023 (07:30:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0417.v1

The Matter of Time

Arto Annila

Subject: Physical Sciences, Acoustics Keywords: arrow of time; causality; change; force; free energy; natural selection; nondeterminism; quantum; period; photon

Online: 15 June 2021 (16:07:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0722.v1

Characterization of Extreme Precipitation Events in the Pyrenees. From the Local to the Synoptic Scale.

Marc Lemus-Canovas, Joan-A. Lopez-Bustins, Javier Martín-Vide, Amar Halifa-Marin, Damián Insua-Costa, Joan Martinez-Artigas, Laura Trapero, Roberto Serrano-Notivoli, José María Cuadrat

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: extreme precipitation; Mediterranean region; Pyrenees; return period; teleconnection indices; weather type.; Backward trajectory; IVT

Online: 27 April 2021 (13:00:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0554.v1

The Microbiome and Mosquito Vectorial Capacity: Rich Potential for Discovery and Translation

Cintia Cansado-Utrilla, Serena Zhao, Philip McCall, Kerri Coon, Grant Hughes

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: microbiome; vectorial capacity; density; competence; biting; extrinsic incubation period; longevity; mosquito; symbiosis; pathogen transmission

Online: 22 December 2020 (10:49:13 CET)

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Working Paper ARTICLE

Period Doubling Phenomenon as the Origin of Electron Properties

Ari Lehto

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: period doubling; electron structure; elementary charge; electron magnetic moment; fine structure constant; Planck scale; Standard Model

Online: 20 August 2020 (04:08:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0002.v1

Long Period Grating-Based Fiber Coupling to WGM Microresonators for Sensing Applications

Francesco Chiavaioli, Dario Laneve, Daniele Farnesi, Mario Christian Falconi, Gualtiero Nunzi Conti, Francesco Baldini, Francesco Prudenzano

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: microresonator; whispering gallery mode; long period grating; fiber coupling; distributed sensing; chemical/biological sensing

Online: 2 July 2018 (07:49:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0189.v1

The Global Burden of Type 2 Diabetes Attributable to Dietary Risks: Insights from the Global Burden of Disease Study 2019

Alina Ioana Forray, Mădălina Adina Coman, Ruxandra Simonescu-Colan, Andreea Isabela Mazga, Răzvan Mircea Cherecheș, Cristina Maria Borzan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: type 2 diabetes mellitus; Global Burden of Disease Study; dietary risk factors; Age- Standardized Mortality Rate; Age-Standardized DALY Rate; Socio-Demographic Index

Online: 4 October 2023 (04:55:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0875.v1

Sleep Quality, Nutrients Intake and Social Development Index predict Metabolic Syndrome in the Tlalpan 2020 Cohort: A Machine Learning and Synthetic Data study

Guadalupe O. Gutiérrez-Esparza, Mireya Martinez-Garcia, Tania A. Ramirez-delReal, Lucero Elizabeth Groves-Miralrio, Manlio F. Marquez, Tomás Pulido, Luis M. Amezcua-Guerra, Enrique Hernández-Lemus

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Poor quality sleep; Social Development Index; Nutrients; Machine learning; Features selection; Balancing methods; Mexico City; Tlalpan 2020 cohort

Online: 11 January 2024 (11:23:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0774.v1

Junxia Li, Zhenguo Wang, Liujia Wang, Xiayuan Wang, Dong He, Xinming Duan, Chunxiang Zhang, Youshe Ren, Chunhe Yang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: cashmere goat; cashmere production; secondary hair follicle; age; oxidative stress

Online: 11 April 2024 (10:12:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1497.v1

Ethnic Representation Matters: Investigating Bias in Facial Age Prediction Models

Nenad Panić, Marina Marjanović, Timea Bezdan

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Facial recognition; Age prediction; Convolutional Neural Network (CNN); Ethnicity bias

Online: 26 March 2024 (08:15:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0998.v1

Development and Implementation of Virtual Reality Application: Age-Friendly Health System Scenario

Sweta Tewary, Oksana Shnayder, Marie Dezine, Naushira Pandya

Subject: Public Health And Healthcare, Primary Health Care Keywords: virtual reality; age friendly health systems; medical education; older adults

Online: 19 February 2024 (15:45:44 CET)

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INTRODUCTION: With an increase in the aging population, the application of evidence-based practice in geriatric education can strengthen knowledge, skills, and clinical experience for healthcare students caring for older adults. Age Friendly Health Systems (AFHS) is one of the frameworks founded on providing evidence-based and low-risk care centered on what matters most to older adults, their families, and caregivers. Virtual Reality (VR) platforms are gaining popularity due to their ability to provide an immersive, hands-on learning experience resembling an actual medical practice or care setting. Immersive learning enhances students’ sensory perceptions, promoting an innovative and engaging way of acquiring concepts that are difficult to teach in real life. This study aimed to design, develop, implement, and evaluate a case-based training module highlighting AFHS and educating medical students on the 4Ms approach in geriatric care (What Matters, Medication, Mentation, and Mobility). METHODOLOGY: The project was a feasibility study completed in two phases. Phase one included planning and development of a case-based scenario incorporating 4Ms of AFHS. Phase two included implementing and evaluating the VR training module into the geriatric curriculum for medical students. RESULTS: The final VR case displays a hospital and post-acute setting where an elderly patient is admitted for a hip fracture. Students learn how to triage and treat patients from admission to discharge while demonstrating their knowledge of AFHS. Approximately 10% of students completed the evaluation survey, and preliminary results indicate significant knowledge change in pre-post scenario-based training on AFHS. CONCLUSION: The VR education platform and embedded scenario promise an innovative adaptation of technology in learning the concepts of the 4Ms of AFHS. However, future studies should explore VR education with clinical assessment evaluation to ensure competence in providing Age-Friendly care.

Preprint REVIEW | doi:10.20944/preprints202402.1022.v1

The Value of Autopsy in the Modern Age: Discrepancy between Clinical and Autopsy Diagnoses

Cecilia Salzillo, Roberta Basile, Gerardo Cazzato, Giuseppe Ingravallo, Andrea Marzullo

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: hospital autopsy; modern age; clinical diagnosis; autopsy diagnosis; Public Health

Online: 19 February 2024 (08:22:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0350.v1

Human Age Estimation from Face Images with Deep Convolutional Neural Networks Using Transfer Learning

Gilbert George, Chandrashekhar Uppin, Usman Abubakar Bello

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Convolution neural network; Deep Learning; Facial Age; Regression; Transfer learning

Online: 4 January 2024 (07:41:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1081.v1

Splenic Stiffness Measured by 3-Tesla Magnetic Resonance Elastography Is Correlated with Age in Healthy Individuals

Süheyl Poçan, Levent Karakaş

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: 3 tesla magnetic resonance; age, healty volunteers; elastography; splenic stiffness

Online: 17 October 2023 (11:20:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1069.v1

Splenic Stiffness Measured by 3-Tesla Magnetic Resonance Elastography Is Correlated with Age in Healthy Individuals

Süheyl Poçan, Levent Karakaş

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: 3 tesla magnetic resonance; age; healty volunteers; elastography; splenic stiffness

Online: 17 October 2023 (11:11:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0861.v1

Pattern of Presentation and Risk Factor Prediction of Acute Myocardial Infarction in Kosovo

Afrim Poniku, Arlind Batalli, Dua Shita, Zarife Rexhaj, Arlind Ferati, Rita Leka, Artan Bajraktari, Genc Abdyli, Edmond Haliti, Pranvera Ibrahimi, Shpend Elezi, Faik Shatri, Ibadete Bytyçi, Michael Henein, Gani Bajraktari

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myocardial infarction; risk factors; smoking; diabetes; arterial hypertension; age; gender

Online: 14 September 2023 (02:34:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0670.v1

Precision and Accuracy of Radiological Bone Age Assessment in Children among Ethnical Groups

Sebastián Eustaquio Martín Pérez, Isidro Miguel Martín Pérez, Jesús Vega González, Ruth Molina Suárez, Coromoto León Hernández, Fidel Rodríguez Hernández, Mario Ulises Herrera Perez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: diagnostic imaging; radiography; age determination by skeleton; racial group; children

Online: 11 September 2023 (11:11:23 CEST)

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Introduction: Determination of radiological bone age (BA) is a diagnostic method that consists of estimating chronological age (CA) from the bone maturation of children. Although environmental and hormonal factors can interfere with bone ossification, the process is essentially dependent on ancestral inheritance. These ethnic backgrounds are not usually considered, which can lead to biased interpretations and inadequate decision-making by pediatricians or forensic experts. The objective of this study was to determine the precision and accuracy of these radiological procedures among different ethnic groups. Methods: A qualitative systematic review carried out following MOOSE statement and previously registered in the International Prospective Registry of Systematic Reviews PROSPERO (CRD42023449512). Search was performed in MEDLINE (PubMed) (n=561), Cochrane Library (n=261), CINAHL (n=103), Web of Science (WOS) (n=181) and public institutional repositories (n=37) from inception to 31st December 2022 using Mesh as “Diagnostic Techniques and Procedures”, “Diagnostic imaging”, “Radiography”, “Age Determination by Skeleton” and free terms combining with booleans “AND” and “OR”. PEDro scale, and Risk of Bias in non-randomized Studies of Exposure (ROBINS-E) were used to assess methodological quality and risk of bias of included studies respectively. Results: 51 articles (n=19,531) were included according to the inclusion criteria previously established. There was a good to moderate methodological quality and a high to very high risk of bias. Skeletal methods for determining BA were precised in terms of intra-observer and inter-observer reliability in all ethnic groups. Regarding to accuracy of Skeletal methods in Caucasians and Hispanic children, GPA was accurate at all ages, but in youths, TW3 RUS could be a consistent alternative. In Asian and Arab, GPA and TW3 overestimated BA in adolescents near adulthood. In African youths, GPA overestimated BA while TW3 was more accurate in estimating CA. Dental and Cervical radiographic methods are equally precise but lesser accurate than Skeletal BA determination. Conclusion: Skeletal radiographic methods GPA and TW3 are both precise for BA determination among all ethnical groups, but their accuracy in estimating CA can be altered by racial bias.

Preprint ARTICLE | doi:10.20944/preprints202306.0653.v1

Determinants of Child Nutritional Status among Scheduled Tribes in West Bengal

Manabindra Barman, Dr. Indrajit Roy Chowdhury

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Scheduled tribe; Children; Nutritional status; Under 5years age; Determinant factors

Online: 9 June 2023 (03:04:37 CEST)

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Malnutrition is the main cause of child mortality in developing nations, especially in Sub-Saharan Africa and South Asian countries. This undernutrition status is predominantly higher among primitive tribal (ST) children under 5 years of age. The nutritional status of tribal children is a serious concern in India. For this, there should be intends to examine the prevalence and determinants of primitive tribal children's nutritional status. To investigate the effect of household, child’s & maternal characteristics on biological children under 5 years of age. The study aims to find out the association between some selected determinants on scheduled tribe child’s nutritional status. The study used some selected variable of scheduled tribe mothers, household characteristics and their children anthropometric indices from DHS datasets of India, which was published by the NFHS datasets of India. In this study People datasets and Children (Under 5 years of age) of interviewed women file datasets of NFHS-IV & V is taken. The datasets of West Bengal, ST mothers, and their child into consideration as per the research interest. Then to analyze the determinants of ST children (U5 age) nutritional status, some determinant factors are taken from mothers, children and household characteristics. Children’s stunting, wasting and underweight as dependent variable and the mothers, child’s and household’s characteristics as independent variable. The statistical analysis was done by using Pearson Chi square test used to analyze the association between dependent and independent variables. The study results shows that the mother’s educational status, child’s age, birth order, size of child at birth, type of residence had significant associations with stunting. Mother's anemia status and mother age had significant associations with wasting. Mother education, currently breastfeeding, child age, sex of the child, birth order, size of child at birth, type of residence, wealth, toilet facility, and cooking fuel shows a significant association with underweight. The results found that many determinant factors had a significant role among ST children's (U5 age) nutritional status. Thus, the findings will help to achieve tentative resource allocation, and utilization through various programs and policies to improve the ST children (U5 age) nutritional status. There is a need to take a multisectoral and multidimensional approach to develop for those primitive tribal children.

Preprint ARTICLE | doi:10.20944/preprints202305.1011.v1

Prevalence of Vitamin B₁₂ and Folate Deficiencies in Indian Children and Adolescents

Tattari Shalini, Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, Hemalatha Rajkumar, Harshpal S Sachdev, Anura V Kurpad, Geereddy Bhanuprakash Reddy

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Vitamin B12 deficiency; Folate deficiency; School-age children; Adolescents; CNNS

Online: 15 May 2023 (09:45:12 CEST)

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Deficiencies of vitamin B12 (B12) and folate (FA) are of particular interest due to their pleiotropic role in 1-carbon metabolism. In addition to adverse birth outcomes, deficiencies of B12 and FA, or an imbalance in FA/B12 status, are linked to metabolic disorders. Indian diets that are predominantly plant food-based could be deficient in these vitamins, but there are no national estimates of the prevalence of B12 and FA deficiency in Indian children and adolescents, nor of their associations with age, sex, and growth indicators. The recent Comprehensive National Nutrition Survey (CNNS-2016-18) provided estimates of the prevalence of B12 and FA deficiency at the national and state level among preschool (1-4y: 9,976 and 11,004 children respectively), school-age children (5-9y: 12,156 and 14,125) and adolescents (10-19y: 11,748 and 13,621). Serum B12 and erythrocyte FA were measured by the direct chemiluminescence method and their deficiency was defined using WHO cut-offs. The prevalence of B12 and FA deficiency was high among adolescents (31.0%, CI: 28.7-33.5 and 35.6%, CI: 33.1-8.2), compared to school-age (17.3%, CI: 15.4-19.3 and 27.6%, CI: 25.5-29.9) and preschool children (13.8%, CI: 11.7-16.2 and 22.8%, CI: 20.5-25.2, respectively). The prevalence of both B12 and FA deficiency was significantly higher by 8 and 5% points respectively, in adolescent boys compared to girls. The prevalence of B12 deficiency was higher in moderately stunted school children (by 18.9% points) than in normal children, but no such difference was observed for FA deficiency. There was wide regional variation in the prevalence of B12 and FA deficiency, but no rural-urban differences were observed across all age groups. The national prevalence of B12 deficiency among preschool or school-age children was <20% (the cut-off that indicates a public health problem). However, FA deficiency in these age groups and both FA and B12 deficiencies in adolescents were >20%, which warrants further investigation.

Preprint ARTICLE | doi:10.20944/preprints202305.0165.v1

Computed Tomographic Features of Thymus Gland in Dogs: Correlation with Age, Gender, Breed and Body Fat Content

Mohammad Molazem, Sarang Soroori, Alireza Bahonar, Saghar Karimi

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Computed tomography, Thymus Gland, Dog, Age, Gender, Breed, Body Fat

Online: 4 May 2023 (02:59:54 CEST)

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: Background: The thymus gland is the first lymphoid organ formed to regulate a newborn's immunity. It reaches its maximum size during puberty, after which it undergoes an atrophic procedure called involution, but its ability to grow again in response to some stresses, such as infections, neoplasia, surgeries, chemotherapy, and radiotherapy is maintained. There is not any comprehensive study on computed tomographic features of thymus gland in dogs. So, the goal of the present study is to achieve some information about thymus gland using computed tomography as a non-invasive method. Methods: One hundred and fifty dogs classified in 5 age groups and 2 breed groups were entered to this study and the thymus gland was evaluated using 2-slice computed tomography machine. The inclusion criteria for the present study were having normal complete blood count, plain and post-contrast CT scan examination of thoracic region and no history of neoplasia, chemotherapy or radiotherapy. The visibility, density, enhancement, grade, size, volume, shape, borders and lateralization of the thymus were evaluated and statistical analysis were performed. The effect of obesity on thymic grade and volume were also investigated. Results: The visibility, density, dorsal length, volume and grade decreased with increasing age. The thymic shape and lateralization were mostly wedge-shaped and left sided respectively. The borders became concave with aging and increasing body fat content caused to increase fatty degeneration of thymus. Conclusions: Declining of thymic density, grade, size and volume with aging was related to thymic involution and fatty degeneration was accelerated by increasing body fat content. Females and Males were different only in thymic shape and small and large breeds were different only in thymic volume. The thymus was visible in some geriatric dogs with no underlying disease. We hope that the present work can be used by radiologists in reading thoracic computed tomography but investigation of thymic characteristics in dogs with neoplasia and history of chemotherapy, radiotherapy and thoracic surgeries can complete this study.

Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0506.v1

A Retrospective Cohort Study of the Clinical Features, Pathological Characteristics, and Molecular Classification in Reproductive Age Patients with Endometrial Cancer who Experienced Unsuccessful Fertility-sparing Treatment

Tong Yu, Xi-Wen Zhang, Ping-Li Sun, Abdulkarim Mohamed Farah, Yan Jia

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometrial cancer; fertility-sparing management; molecular classification; reproductive age; pregnancy

Online: 26 November 2021 (12:42:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0446.v1

Non-Modifiable Risk Factors (Age and Sex), Stroke Types, and Outcomes in Rivers State, Nigeria: A Retrospective Hospital-Based Study

Osborne Ikechuckwu Osuegbu, Foluke Olukemi Adeniji, Golden Chukwuemaka Owhonda, Rogers Bariture Kanee, M Alblihed, Gaber El-Saber Batiha, Eric Osamudiamwen Aigbogun

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Age; Sex; Stroke Types; Outcomes; SEM; Tertiary Hospitals; Rivers State

Online: 20 July 2021 (11:45:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0696.v1

Revealed Preferences of Fourth Graders When Requesting Face-to-Face Help While Doing Math Exercises Online

Roberto Araya, Raúl Gormaz

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Help Seeking; Same-age Peer Tutoring; Revealed Preferences; Data analytics

Online: 29 June 2021 (11:36:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0392.v1

Prevalence of Controlled Systemic Hypertension and Its Associated Risk Factors among Hypertensive Patients at Mbeya Zonal Referral Hospital, Tanzania.

Samson Peter Mvandal, Victor Jastin Mwinuka

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Age; adherence; anti-hypertensive; Controlled hypertension; clinic; hypertension; Prevalence; Systemic

Online: 17 May 2021 (15:57:01 CEST)

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Working Paper REVIEW

A Systematic Review of Neuroimaging and Acute Cannabis Exposure in Age-of-Risk for Psychosis

Lani Cupo, Eric Plitman, Elisa Guma, M Mallar Chakravarty

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: systematic review; cannabis; neuroimaging; age-of-onset psychosis; psychosis; schizophrenia

Online: 14 May 2021 (09:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0589.v1

Compaction Model for Shale in Differences of Geological Ages Using A 3D Empirical Relationship in Northeastern Thailand

Avirut Puttiwongrak, Syukratun Nufus, Chaiyaphruk Bunprasert, Pham Huy Giao, Sakanann Vann, Thongchai Suteerasak, Nophea Sasaki

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Shale compaction; Geological age; Thailand shale; Compaction model; Standard curve

Online: 21 April 2021 (16:50:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0478.v1

Quality of Life: Changes in Self Perception in People with DS who Participate in Laliga Genuine Santander. Self Reports and External Reports

Rocío Camacho, Cristina Castejón-Riber, Francisco Requena, Julio Camacho, Arturo Gallego, Roberto Espejo, Amaranta De Miguel-Rubio, Begoña M. Escribano, Estrella I. Agüera

Subject: Social Sciences, Psychology Keywords: Down's Syndrome; perception; quality of life; sport; age; gender; scale

Online: 18 December 2020 (16:17:41 CET)

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