PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study
Version 1
: Received: 1 November 2018 / Approved: 8 November 2018 / Online: 8 November 2018 (14:00:01 CET)
How to cite:
Bai, S.; Lee, K.; Kim, S.S.; Hong, J.H.; Nam, H.J.; Koh, J.C.; Kim, N.Y. Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study. Preprints2018, 2018110005. https://doi.org/10.20944/preprints201811.0005.v1
Bai, S.; Lee, K.; Kim, S.S.; Hong, J.H.; Nam, H.J.; Koh, J.C.; Kim, N.Y. Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study. Preprints 2018, 2018110005. https://doi.org/10.20944/preprints201811.0005.v1
Bai, S.; Lee, K.; Kim, S.S.; Hong, J.H.; Nam, H.J.; Koh, J.C.; Kim, N.Y. Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study. Preprints2018, 2018110005. https://doi.org/10.20944/preprints201811.0005.v1
APA Style
Bai, S., Lee, K., Kim, S.S., Hong, J.H., Nam, H.J., Koh, J.C., & Kim, N.Y. (2018). Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study. Preprints. https://doi.org/10.20944/preprints201811.0005.v1
Chicago/Turabian Style
Bai, S., Jae Chul Koh and Na Young Kim. 2018 "Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study" Preprints. https://doi.org/10.20944/preprints201811.0005.v1
Abstract
There is a lack of data comparing sugammadex with anticholinesterase for the quality of anaesthesia recovery, especially following a single bolus dose of rocuronium. Thus, we evaluated the influence of reversal with sugammadex or neostigmine on post-operative quality of recovery by using the Post-operative Quality Recovery Scale (PQRS). A total of 86 patients undergoing trans-pars plana vitrectomy (TPPV) under general anaesthesia were intubated following a single bolus dose of rocuronium (0.6 mg/kg). At the end of surgery, patients were received either neostigmine or sugammadex. The quality of recovery was assessed using the PQRS at 15 minutes and 40 minutes after surgery, and on post-operative day 1. The recovery rate in the physiological domain was higher in the sugammadex group at 15 minutes after surgery (P = 0.02). Though there were no significant differences in the overall cognitive recovery domain, patients in the sugammadex group could recall more numbers in reverse order. However, there were no significant differences between the groups in the other domains of the PQRS. The use of sugammadex may increase the quality of the post-operative physiological recovery at early post-operative periods compared with neostigmine use following a single bolus dose of rocuronium in patients undergoing TPPV with general anaesthesia.
Keywords
anaesthesia, general; anaesthesia recovery period; single dose of rocuronium; sugammadex; neostigmine
Subject
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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