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Sleep Quality, Nutrients Intake and Social Development Index predict Metabolic Syndrome in the Tlalpan 2020 Cohort: A Machine Learning and Synthetic Data study

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10 January 2024

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11 January 2024

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Abstract
Metabolic Syndrome (MetS) is a serious condition that significantly increases the risk of cardiovascular diseases and the severity of type 2 diabetes, also impacting on the development and evolution of other chronic diseases. Predicting metabolic syndrome is a complex task due to the multifactorial nature of this condition, which involves a combination of various risk factors such as abdominal obesity, insulin resistance, dyslipidemia, and hypertension. The complex interplay of these factors makes it challenging to predict the syndrome. Both genetic predisposition and environmental factors also contribute to the development of metabolic syndrome. Metabolic syndrome affects diverse populations with different ethnicities, lifestyles, and socioeconomic backgrounds. Prediction models, in addition, need to account for population heterogeneity and consider variations in risk factors across different groups. The present study analyzed data from participants in a cohort from Mexico City to identify key risk factors in men and women, addressing the presence of unbalanced data. In order to tackle the issues posed by data imbalance data, SMOTE and ADASYN were applied to assess significant differences in the selection of risk factors for MetS prediction. Random Forest and RPART models using ADASYN and SMOTE demonstrated better performance, achieving a balanced accuracy of approximately 87%. In women, they highlighted sleep quality, anxiety factors, tobacco consumption, and nutritional components. In the case of men, stronger associations were identified with the social development index and factors related to gout in parents.
Keywords: 
Poor quality sleep
;  
Social Development Index
;  
Nutrients
;  
Machine learning
;  
Features selection
;  
Balancing methods
;  
Mexico City
;  
Tlalpan 2020 cohort
Subject: 
Medicine and Pharmacology  -   Cardiac and Cardiovascular Systems

1. Introduction

Metabolic Syndrome is a condition that increases the risk of developing or worsening several serious health conditions such as type 2 diabetes (one of its components), heart disease, and stroke, as well as cognitive decline and dementia [1]. Among the factors associated with MetS is poor quality of sleep or sleep disturbances such as insomnia, apnea, and snoring, which can, in turn, cause a range of other negative consequences [2,3]. In 2017, the National Health and Nutrition Survey of Mexico [4] estimated the prevalence of sleep disorders in Mexicans using a sample of 8,649 people older than 18 years old. The results showed a prevalence of snoring while sleeping of 48.5%, difficulty to sleep of 36.9%, and tiredness or fatigue during the day of 32.4%; likewise, insomnia was 18.8% more prevalent in women. In the apnea case, the result indicated that 23.7% had a higher risk of presenting apnea, especially the population overweight and obese, hypertensive, and those over 40 years of age. In another study, [5], the prevalence of insomnia was 36.7%, being more common among women (with a prevalence of 41.9%) than in men (with a prevalence of 36.7%). Sleep disorder treatment depends on the disorder type and the underlying cause. For this reason, it is necessary efforts to improve diagnosis and treatment.
Nutrition plays a crucial role in the development and management of metabolic syndrome. Metabolic syndrome is a cluster of conditions that includes abdominal obesity, insulin resistance, dyslipidemia, and hypertension. Poor dietary choices, along with other lifestyle factors, can contribute to the development and exacerbation of these risk factors [6,7]. Excessive caloric intake, especially from high-fat and high-sugar diets, contributes to obesity. Diets rich in added sugars and refined carbohydrates can contribute to insulin resistance, a key feature of metabolic syndrome. Low consumption of dietary fiber, commonly found in fruits, vegetables, and whole grains, is associated with insulin resistance. Diets high in saturated and trans fats can lead to dyslipidemia, characterized by elevated levels of triglycerides and low-density lipoprotein cholesterol, and decreased high-density lipoprotein cholesterol. This lipid profile is a risk factor for cardiovascular diseases associated with metabolic syndrome. In contrast, omega-3 fatty acids, found in fatty fish, flaxseeds, and walnuts, have been associated with favorable lipid profiles and may have a protective effect against metabolic syndrome [8,9,10].
In the same way, another factor significantly associated with MetS is social development index (SDI) [11], a composite measure of social and economic development. Countries with higher SDI tend to have better health outcomes, including lower rates of MetS [12], and an additional study connects the risk of MetS with economic and social vulnerability as well as inappropriate nutrition profiles [13]. Evidence suggests a close association between SDI and sleep disturbances may be influenced by social and economic factors, such as income and education. Therefore, studying the relationship between sleep disturbance, SDI, and MetS could help identify the social and economic determinants and the types of sleep disturbance that increase the prevalence of MetS. This could inform the development of more effective strategies for preventing and treating MetS and improving overall health and well-being. For this reason, developing automated approaches for diagnosing sleep disorders, identifying the determinants of SDI, and predicting MetS have become active research areas.
In the case of sleep disruption, machine learning has shown promise in improving the accuracy and efficiency of the diagnosis process. The work of Mencar et al. [14] presents the application of five machine learning models to predict the severity of obstructive sleep apnea syndrome (OSAS) using polysomnography data, where the random forest model got the highest accuracy (90.91%) and relevant features such as respiratory rate and oxygen saturation were extracted. Another study [15] applies a machine learning model to predict the presence of OSAS using clinical and demographic data. The random forest model performed best, achieving an accuracy of 87.1%. The most important predictors were body mass index (BMI), age and gender, besides additional predictors, such as neck circumference and smoking.
In another study by Eyvazlou et al. [16], an ANN model was developed to predict MetS based on sleep quality and work-related risk factors. The results showed that the ANN model could identify individuals at risk of MetS with a sensitivity of 74.1% and a specificity of 76.2%. Moreover, other studies [17,18] have also applied machine learning to understand the social determinants that affect and influence the health of individuals.
However, despite the excellent results described in previous studies, one of the most common challenges in medical diagnosis is the issue of class imbalance. This problem significantly impacts the performance of classifiers, as they tend to exhibit a bias towards the majority class, resulting in skewed outcomes. In this context, authors such as Kim et al. [19] propose a prediction model that utilizes balancing techniques to identify middle-aged Korean individuals at a high risk of MetS. The dataset used in their study comprises age, gender, anthropometric data, sleep quality, and blood indicators of 1991 individuals. The results showed that XGBoost, employing SMOTE, achieved an AUC of 85.1%.
As expected, nutrition and dietary habits are associated with MetS; Jung et al. [20] analyzed the association between dietary habits, shift work, and MetS in Korean women dedicated to being nurses. They found an association with alcohol, black coffee, and soft drinks consumption, applying a regression model. It is essential to mention that specific studies demonstrate the impact of nutrients associated with MetS [21], leading to helpful insights on lipid profiles, primarily those contained in fish (proteins, n-3 fatty acids, vitamin D, iodine, selenium, and taurine) [22]. Likewise, investigations through statistical analyses in Saudi Arabia [23] indicate that insufficient nutrients of vitamins A, C, E, K, calcium, zinc, and magnesium may increase the risk for MetS, mainly in adult women. Nevertheless, Bian et al. [24] found that vitamin B has a healthy impact on preventing MetS, and they made a regression model for a controlled study in Chinese adults.
The present study aims to examine the connection between the SDI, sleep disturbances, types of nutrients consumed, and MetS within a cohort from Mexico City. Our goal is to identify critical factors that may be key to reducing MetS incidence or severity by applying machine learning algorithms. Additionally, we will use data balancing techniques to improve the predictive performance of our models and enhance feature selection. By incorporating these methods, we aim to uncover valuable insights and contribute to developing more accurate and practical approaches for addressing MetS.
This paper is structured as follows: Section 2 introduces materials and methods. In Section 3, we explain the experiments performed and the results. Section 4 delivers the discussion and, ultimately, the conclusions.

2. Materials and Methods

2.1. Data

Data for this study was derived from the baseline assessment of a cohort called Tlalpan 2020 from the National Institute of Cardiology Ignacio Chávez in Mexico City [25]. This project was authorized by the Institutional Bioethics Committee of the National Institute of Cardiology Ignacio Chavez under code 13-802. The dataset used in this investigation includes data from 3156 volunteers (all of them were informed of the research purposes and signed a letter of informed consent) about their anthropometric measurements, consumption of alcohol and tobacco, level of physical activity, level of economic income, level of education, anxiety, family history health, biomedical evaluation, quality of sleep and the amount of nutrients consumed.

2.1.1. Quality of sleep

The sleep quality was measured by Medical Outcomes Study (MOS) [26], a self-report for assessing sleep quality and quantity. This questionnaire includes 12 items about sleep disruption, snoring, sleep shortness of breath or headache, sleep adequacy, and sleep somnolence; it additionally measures the number of hours of sleep per day during the past four weeks. The MOS has been used in several research such as discriminating the quality of sleep among a Spanish postmenopausal population [27], diagnosing cases of apnea [28,29] or identifying sleep disturbance in patients with rheumatoid arthritis [30], among others.

2.1.2. Clinical and anthropometric parameters

Clinical and anthropometric data such as systolic blood pressure (SBP) and diastolic blood pressure (DBP) (measured according to standard procedure [31]) were collected, as well as waist circumference (WC), height and weight (measured according to ISAK [32]), in the case of BMI and the height-waist index (WHtR) these were calculated from primary measurement data.

2.1.3. Biochemical evaluation

The following laboratory tests measurements corresponding to blood samples were included: glucose (GLU), triglycerides (TGs), HDL cholesterol (HDL), LDL cholesterol (LDL), uric acid (URIC), atherogenic index (IAT), and sodium (NA).

2.1.4. Habits and factors associated with lifestyle

Furthermore, habit data was also collected, such as the smoking habit, alcohol consumption and physical activity (calculated based on the International Physical Activity Questionnaire, IPAQ, [33] by metabolic equivalents minutes/week, which are classified in the following categories: low, moderate, and high).
Education level was collected and classified into three categories: primary school, high school, and university studies, as well as postgraduate school. Similarly, we collected the level of economic income, which was classified into three categories based on the Mexican peso: low ($1.00 to $6,600.00), medium ($6,601.00 to $11,000.00), and high (more than $11,000.00), on a monthly basis.

2.1.5. Psychological stress level

We used the State-Trait Anxiety Inventory (STAI) to collect data about psychological stress level, which was categorized into five categories: high (>65), moderate (56-65), medium (46-55), minor (36-45) and low (<35) [34,35].

2.1.6. Dietary information

To gather information about the frequency of food consumption and other dietary products, we utilize a software tool called the “Evaluation of Nutritional Habits and Nutrient Consumption System" [36]. This system examines the meals individuals have consumed over a day within the previous year and computes the quantity of nutrients ingested.
All data mentioned in this section are presented in the Table 1.

2.2. Methods

2.2.1. Feature selection

Feature selection is essential to identify and establish the most critical variables.
In this study, we employed logistic regression to measure the relationship between variables and class, alongside machine learning algorithms to discern the most significant features. The algorithms used were RF and RPART (see Methods below), applying the mean decrease accuracy for calculating variable importance which can be expressed as follows:
M D I i = ∑ a l l n o d e s ( ( I m p ( n o d e ) − W e i g h t . I m p ( n o d e ) ) / N S . N )
where: M D I i is the mean decrease impurity of the i t h variable I m p ( n o d e ) is the impurity of the node before the split; W e i g h t . I m p ( n o d e ) is the weighted impurity of the child nodes resulting from the split N S . N is the number of samples in the node before the split.

2.2.2. Balancing methods

Balancing methods such as SMOTE and ADASYN have helped address the class imbalance issue within our dataset.
ADASYN (Adaptive Synthetic Sampling), which is part of the UBL R package, takes a unique approach by generating synthetic samples based on the local density of minority class instances, with a focus on instances that are more challenging to learn. In this method, the β parameter controls the desired balance rate between the minority and majority classes during the generation of synthetic samples. When β is set to a value greater than 1, a proportionally larger number of synthetic samples will be generated relative to the instances of the minority class. This further increases the ratio between the minority and majority classes.
The second method, SMOTE (Synthetic Minority Oversampling Technique) of the performanceEstimation R package, generates synthetic samples for the minority class. In SMOTE, the k parameter determines the number of nearest neighbors used to generate synthetic samples. A small value of k can lead to an excessive generation of synthetic samples that may be too close together, resulting in model overfitting. Moreover, if k is too large, synthetic samples may be less representative of the minority class and fail to capture data variability adequately.

2.2.3. Methods

To build the models, we applied two machine learning algorithms, RF [37,38] and RPART [39,40], as well as PCA [41,42]. RF, introduced by Breiman [43], is a machine-learning algorithm combining multiple decision trees to create a model with the highest accuracy. Rpart (Recursive Partitioning and Regression Trees), by Breiman [44], works by recursively partitioning the input data based on predictor variables to create a tree-like structure. This algorithm aims to find the optimal splits in the data that maximize the homogeneity or purity of the resulting subgroups. Principal component analysis (PCA) is a data analysis technique used to simplify the complexity of data by reducing its dimensionality facilitating visualization and analysis.

2.3. Performance measures

To evaluate model performance, we used sensitivity, specificity, and balanced accuracy (B.ACC). These metrics provide a fair assessment of the model’s performance across all classes, considering the issue of class imbalance.
S E N S = T P T P + F N
S P C = T N F P + T N
B . A C C = 1 2 T P P + T N N
Where P = Positive, N = Negative, TP = True Positive, FN = False Negative, TN = True Negative and FP = False Positive, respectively.

3. Statistical analysis and development of prediction models

All experiments were performed using the R programming language (3.6.1) [45]. Min-max was used to normalize continuous variables, and dichotomous variables were represented as numbers. Figure 1 provides a general overview of the experimental process described in this section. To develop predictive models, it was necessary to process the data and implement a balancing technique. The minority class was oversampled, taking into account the majority class. As a first step, SMOTE was applied, and it was necessary to determine the best value of k (number of nearest neighbors), so experiments were conducted by varying k (here we present k = 1 , k = 5 , and k = 9 ). In this process, the dataset was randomly divided into 70% for training and 30% for testing. To accomplish this task, we applied two machine learning algorithms, RF and RPART. In the case of RF, we varied the mtry parameter from 1 to 10 and considered ntree values of 100, 300, 500, and 1000 for each model.
Additionally, a subset of features was extracted in each created model using the variable importance (VarImp) of RF, and a 10-fold cross-validation was performed. Similarly, in the case of RPART, parameter tuning was conducted by considering c p = 0 , c p = 0.05 , and c p = 0.005 , using a 10-fold cross-validation. Likewise, a subset of features was extracted in each created model.
Once the feature subsets were obtained, along with the optimal value for each corresponding parameter of each algorithm and data balancing technique, we tested the generated feature subsets using RF and RPART. This was done by conducting 30 runs with different seeds to assess the performance of each model. In all experiments, a minimum of 30 independent runs were conducted for each algorithm using 30 different seeds. The mean and standard deviation of the performance measures were calculated for each of these runs.

4. Results

Understanding how MetS, nutrition, sleep disturbances, and SDI relate in men and women can have important clinical and public health implications. In this study, we used logistic regression before dataset balancing to pinpoint the critical variables associated with MetS in both female and male populations. Table 2 presents the results of the features and their corresponding values obtained. Detailed results for women can be found in Supplementary Table 1, and those for men are available in Supplementary Table 2.
Analyzing the data, in men, the top 10 variables most related to MetS are blood glucose (GLU), triglycerides (TRIG), waist circumference (WC), atherogenic index (IAT), systolic blood pressure (SBP), vitamin B12 (B12), body mass index (BMI), lactose (LACT), carbohydrates (CARBO), and high glucose levels based on the dietary survey (GLU_1). Conversely, in women, the ten most relevant variables include GLU, TRIG, WC, BMI, SBP, total proteins (PROTEI), fructose (FRUCT), high cholesterol total based on the dietary survey (CHOL_SN), uric acid (URIC), and cooper (CU). To achieve a more effective visualization of these prominent features from the logistic regression for both men and women, Figure 2 is presented. Pink triangle symbols represent the most substantial variables for women, while blue triangles represent those for men. A cautionary note must be made for the seemingly outlier behavior of blood glucose and triglycerides with very high coefficients. Let us recall that these features are closely related to the very definition of MetS. Such variables were included in our models only for the sake of database completeness and comprehensiveness.
Subsequently, we employed SMOTE and ADASYN with RF and RPART to reassess the most influential features associated with MetS prediction within a now balanced dataset. Following this, with the data balancing techniques effectively applied and their parameters fine-tuned, we extract feature subsets by utilizing RPART and RF for both women and men. Extracting features related to MetS in a balanced dataset improves model generalization (conducting training more evenly and accurately), optimizing performance and reducing overfitting. Considering the challenges associated with including all variables in a model, such as noise, redundancy, and overfitting, we extract the 17 variables with the highest values obtained in each model of RF and RPART after applying SMOTE and ADASYN.
The extracted feature subsets, along with their respective values, are presented in Table 3, Table 4, Table 5 and Table 6. These tables also detail the employed balancing technique for each set of variables and their corresponding parameters ranging from 1 to 5. Each subset was adjusted for its corresponding parameter—B for ADASYN and k for SMOTE, considering values of 1 and 5.
Similarly, Table 7 showcases the performance achieved by the RF algorithm, while Table 8 presents the performance of the RPART algorithm. In both tables, the Value column provides information regarding the relative importance of each feature.

4.1. Best Features for Men Using RF and ADASYN/SMOTE

Specifically, Table 3 exhibits four feature subsets obtained from male data using Random Forest with ADASYN and SMOTE. According to Table 7, the most effective subset was obtained by applying ADASYN with B = 1 with a balanced accuracy of 86.22% and a deviation standard of 0.26%.
The most influential feature in this subset is BMI, with a high importance value of 92.9499, followed by WEIGHT and energy efficiency (ENER_AD), with values of 49.4782 and 48.8887, respectively. The other listed features, such as educational lag (EDULAG), common-law marriage (LIV_TOG), durable goods (DURAB), and gout mother (MOTHERGT), also contribute to the model but to a lesser extent.

4.2. Best Features for Men Using RPART and ADASYN/SMOTE

In the case of features obtained by RPART, using both SMOTE and ADASYN, the results were slightly worse than those obtained with RF (see Table 3). In this scenario, the best subset was achieved by the subset with the parameter ADASYN = 5, which achieved an 82.32% balanced accuracy metric with a standard deviation of 0.99%.
Switching gears to the outcomes yielded by Random Forest with ADASYN using a B value of 5, BMI takes center stage with a substantial value of 683.74, signifying its paramount role in predicting the outcomes related to the examined condition. Following closely in significance are energy efficiency (ENERGY_AD) and educational lag (EDULAG), boasting values of 619.99 and 565.33, respectively, both making substantial contributions to predictive capability. ALCOHOL and WEIGHT also exhibit noteworthy importance with values of 355.97 and 295.25, underlining their relevance within the model. Moreover, features like divorced (DIVORC), no degree (NONE), and gout mother (MOTHERGT), while exerting a comparatively lower influence, still contribute to the model’s predictive capacity, as indicated by their respective values.

4.3. Best Features for Women Using RF and ADASYN/SMOTE

The Random Forest model using SMOTE with k = 5 achieved the best performance for women, reaching an 88.50% accuracy with a standard deviation of 0.40% (see Table 7). In this case, Table 5 shows that BMI emerged as the foremost predictor, boasting a substantial value of 484.31, unequivocally underscoring the pivotal role of body mass index in forecasting MetS within this specific context. Furthermore, IAT (481.48) and WEIGHT (339.17) exhibited pronounced associations, reaffirming the significance of weight-related metrics.
Including sleep disturbances (SLPSNR1, SLPSOB1, BREATH, DROWSY, and SLPNOTQ) and even cholesterol levels (CHOL_ANT) among the influential variables underscores their pivotal contributions to MetS prediction in women. The importance of age (AGE) and SDI parameters like sanitary adequacy (SANITRY) is also noteworthy. It is essential to highlight that Psychological factors such as TRAIT_ANX (trait anxiety) were included, accounting for the potential influence of mental health aspects in MetS prediction.

4.4. Best Features for Women Using RPART and ADASYN/SMOTE

In this instance, SMOTE with k = 5, combined with RPART, achieves the best performance, attaining a balanced accuracy of 84.49% with a standard deviation of 1.43% (see Table 6). The results of the corresponding subset (RPART applied to women’s data using SMOTE with a parameter value, k = 5 ) showed in Table 6 reveal that the most influential feature is IAT, with a value of 483.23, followed closely by BMI and WEIGHT, which have values of 410.37 and 409.78, respectively. Features like uric acid (URIC), snores during sleep (SLPSNR1), and smoking practice (SMOKING) also exhibit noticeable influence, indicating their relevance in understanding the targeted phenomenon. Conversely, features like maltose (MALT) and fructose (FRUCT) have relatively lower values; however, they can provide valuable information about dietary habits, nutritional deficiencies, or behaviors related to MetS.
The study’s results, employing Random Forest and RPART algorithms and SMOTE and ADASYN techniques for both genders, offer valuable insights. These results underscore the importance of health and lifestyle elements in MetS prediction, encompassing sleep disturbances, cholesterol levels, age, psychological factors, and SDI parameters.

4.5. Analyzing the best features using PCA

Based on the results of the features obtained in the best models, we used PCA to visually and graphically analyze the top features for men and women to explore potential correlations and latent patterns among these influential factors and reduce dimensionality to the extent possible.
In the case of men, we considered feature subsets obtained from the Random Forest model using ADASYN with B = 1 and RPART with ADASYN and B = 5. The subsequent features were integrated: BMI, WEIGHT, ENER_AD, EDULAG, LIV_TOG, DURAB, MOTHERGT, IAT, HEALTHAC, DIVORC, QUA_HOUS, STRATUM, FATHERGT, NONE, MARRIED, VALUE, URIC, SANITRY, SINGLE and ALCOHOL.
For women, we considered feature subsets obtained from the Random Forest model with SMOTE and k = 5 and the RPART model with SMOTE and k = 5 . These models are regarded because they achieved the highest performance (see Table 7 and Table 8. Extremely small percentage uncertainty values in Table 8 are shown rounded down to 0.00 for clearer presentation). The following features were included: BMI, IAT, WEIGHT, URIC, SLPSNR1, CHOL_ANT, AGE, SLPSOB1, BREATH, TRAIT_ANX, SMO_PASS, SANITRY, MOTHERDL, DROWSY, SMOKING, SINGLE, EXSMOKER, SEC_SCHOOL, SLPNOTQ, SLPS3, SODIUM, ALCOHOL, SATFAT, MONFAT, NA, VITE, FATHERDB, SUCR, MARRIED, FRUCT, ZN, MALT.
The PCA analysis, as shown in Figure 3, revealed the relative importance of features concerning MetS in men. The first principal component (PC1) was more influenced by features such as Weight (WEIGHT), body mass index (BMI), and SDI by value (VALUE), suggesting that these variables significantly contributed to the observed variability in the data. On the other hand, the second principal component (PC2) was more affected by features like educational lag (EDULAG) and socioeconomic stratum (STRATUM). These findings indicated that Weight and BMI were prominent factors in the context of MetS, as well as education and socioeconomic stratum. In this case, PC1 was considered the most significant component, as it had a magnitude of 0.508501, capturing most of the variability, while PC2 had a magnitude of 0.499809.
On the other hand, in the case of women (see Figure ??), features associated with the variability of MetS along PC1 were sodium levels based on the dietary survey (SODIUM), saturated fat (SATFAT), and monosaturated fat (MONFAT), which exhibit significant magnitudes in PC1. Furthermore, BMI also significantly influences PC1, indicating its association with this variability. Conversely, variables like sleep short (SLPSOB1) and waking up with shortness of breath (BREATH) demonstrate significant magnitudes in PC2. Similarly, trait anxiety (TRAIT_ANX) and feeling drowsy or sleepy (DROWSY) are also associated with variability in PC2. Therefore, considering the magnitudes in the principal components, the features in women associated with the risk of MetS include SODIUM, SATFAT, and MONFAT from PC1, as well as SLPNOTQ and SLPSOB1 from PC2.

5. Discussion

MetS is a severe and potentially life-threatening condition that significantly increases the risk of developing cardiovascular diseases also increasing the severity of diabetes. Over the years, several consistently highlighted risk factors have been associated with MetS. This study analyzed participant data from a cohort to identify the primary risk factors in both men and women, considering imbalanced data. Subsequently, data balancing techniques were applied to ascertain whether significant differences exist, contributing to selecting risk factors for MetS prediction. Using data balancing techniques is crucial in this context, as it helps ensure a more accurate and unbiased identification of relevant risk factors, especially when working with unevenly distributed data. In this study, we applied logistic regression to identify the risk factors in men and women that predict the occurrence of MetS within an imbalanced data environment.

5.1. Logistic regression

The logistic regression analysis in women demonstrates (as expected, of course) the strong connection between MetS and elevated glucose levels (GLU), in line with prior research [46,47] emphasizing the crucial role of glucose in MetS. Additionally, uric acid (URIC) is also identified as a significant risk factor in women [48,49,50]. Subsequent findings revealed other risk factors, including waist circumference (WC), body mass index (BMI), and systolic blood pressure (SBP), all essential components of MetS. WC is an indicator of abdominal obesity closely linked to insulin resistance, while BMI reflects the relationship between Weight and height, a significant obesity-related risk factor for MetS. Similarly, elevated SBP represents another component of MetS.
Furthermore, Figure 2 highlights additional significant factors derived from dietary data, including the intake of protein and fructose [51,52,53]. When these two nutrients are combined, they have been linked to an elevated risk of MetS [54]. Likewise, high copper (CU) consumption is evident, which can impact glucose regulation [3] and liver function, both crucial components in MetS [55]. These factors underscore the importance of moderate consumption of these nutrients in preventing MetS.
In the case of men, glucose (GLU) was identified as the primary factor associated with MetS, followed by triglycerides (TRIG), waist circumference (WC), the atherogenic index (IAT), and systolic blood pressure (SBP). Additionally, the consumption of lactose (LACT) [56] and carbohydrates (CARBO) [57] was noted among the nutrients. Elevated glucose, triglycerides, and waist circumference are critical markers of MetS, while the atherogenic index assesses cardiovascular risk. High systolic blood pressure is another significant component of this syndrome. Regarding lactose, it’s worth noting that certain dairy products may include added sugars, which can potentially increase the overall calorie intake [58], potentially contributing to obesity and insulin resistance, two critical factors in the onset of MetS. Moreover, high lactose consumption is associated with a risk factor for developing diabetes, cardiovascular diseases, and increased cholesterol levels [59,60].
It is possible that when working with unbalanced datasets, machine learning models like logistic regression tend to be biased towards the majority class. For this reason, data balancing techniques such as SMOTE and ADASYN were used to enable a more equitable training of the models to identify more precise relationships between variables and the MetS.

5.2. Use of machine learning with synthetic data

The most effective machine learning models for women revealed associations with attributes related to sleep quality, such as snores during sleep (SLPSNR1) [61], sleep short (SLPSOB1) [62], waking up with shortness of breath (BREATH) [63], restless sleep (SLPNOTQ) [64], and somnolence (SLPS3). Multiple studies have shown that poor sleep quality is closely linked to cardiovascular disease [65,66], diabetes [67], and MetS [68], as well as other adverse health outcomes. In the case of women, an increased likelihood of facing significant risks related to cardiovascular diseases and sleep problems has been observed, especially for those in the postmenopausal stage, which, in turn, can contribute to the development of risks associated with MetS [69]. Additionally, they highlighted factors related to anxiety (TRAIT_ANX), despite the association between MetS and anxiety remaining a subject of debate due to various issues [70], this study, like some others [71,72,73,74], identified anxiety as one of the critical factors that predisposing women to MetS.
In the same way, ex-smokers and current smokers (EXSMOKER, SMOKING) were found as features; based on this, it has been observed that both smokers and former smokers are predisposed to MetS. This finding is supported by various studies that suggest that smoking can have an adverse impact on blood lipid levels and lead to metabolic disturbances [75,76,77].
In women, nutritional components also appeared as relevant features, such as saturated fat (SATFAT), monounsaturated fat (MONFAT), sucrose (SUCR), fructose (FRUCT), and maltose (MALT). Based on this, a study has revealed that fructose, sucrose, and maltose are critical components of the leading nutrient pattern associated with a higher risk of MetS [54].
In the case of men, the most effective machine learning models displayed more pronounced associations with features linked to the SDI, encompassing energy efficiency (ENER_AD), educational lag (EDULAG), durable goods (DURAB, HEALTHHAC), quality and living space (QUA_HOUS), socioeconomic stratum (STRATUM), SDI by value (VALUE), and sanity adequacy (SANITRY). In studies [12,78,79,80], a significant association has been observed between a low socioeconomic level and the prevalence of metabolic syndrome. Furthermore, these models underscored variables related to parental gout conditions (MOTHERGT, FATHERGT). This supports research exploring the genetic predisposition to gout and suggests that a family history of this disease may increase the risk of other family members developing it [81]. This condition may also be related to metabolic syndrome due to poor dietary habits that could lead to obesity and insulin resistance [82,83].

5.3. Principal Component Analysis

Based on the resulting features obtained for men and women via machine learning models, we applied Principal Component Analysis to identify trends and potential correlations. The PCA conducted using the features obtained for men (Figure 3 and Figure 4) showed that PC1 (the most significant component) revealed a strong association of body-related factors, specifically Weight (WEIGHT) and body mass index (BMI). PC2 shows a strong correlation among variables related to the SDI. This indicates that the SDI plays a significant role in the onset of MetS, in addition to focusing on interventions related to Weight and obesity management.
Figure 3, depicts the distribution of participants in clusters, where Cluster 2, highlighted in green, turned out to be the cluster most predisposed to developing MetS. Additionally, Figure 4 offers a detailed view of the arrows and the direction of variables in the PCA. These arrows emphasize the contribution of individual features to the principal components.
In the context of MetS in women, the most influential factors in PC1 were factors related to dietary components such as sodium levels based on the dietary survey (SODIUM), saturated fats (SATFAT), and monounsaturated fats (MONFAT), sucrose (SUCR) and fructose (FRUCT), among others. PC2 exhibits a trend towards variables related to poor quality of sleep and anxiety, as sleep short (SLPSOB1), trait anxiety (TRAIT_ANX), SLPNOTQ, and somnolence (SLPS3) have significant values in this component. Other variables related to smoking and education (SEC_SCHOOL) also have a notable influence on this component. This suggests that dietary control is crucial in preventing MetS among women, as well as addressing poor sleep quality and anxiety. Hence PCA highlights relevant differences in the presentation and risk factors of MetS between men and women [84,85], an issue that is progressively gaining relevance in the biomedical literature [86].
The PCA results for women illustrated in Figure 6 shows the distribution of participants in clusters. Similarly to the men’s analysis, the cluster most predisposed to developing MetS was Cluster 2, depicted by yellow dots. Additionally, Figure 7 provides a closer examination of the arrows and the direction of variables in the PCA.
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Figure 5. Top features for men and women considering the results of RF and RPART applying balancing techniques.
Figure 5. Top features for men and women considering the results of RF and RPART applying balancing techniques.
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Figure 6. PCA of features of Women for metabolic syndrome with clusters.
Figure 6. PCA of features of Women for metabolic syndrome with clusters.
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Figure 7. Direction of variables in the PCA women.
Figure 7. Direction of variables in the PCA women.
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6. Conclusion

In this study, we utilized logistic regression as the initial step before dataset balancing, aiming to discern the features closely related to MetS within both male and female populations. Our findings revealed that among men, the top 10 variables showed the strongest associations with MetS encompassed blood glucose (GLU), triglycerides (TRIG), waist circumference (WC), atherogenic index (IAT), systolic blood pressure (SBP), vitamin B12 (B12), body mass index (BMI), lactose (LACT), carbohydrates (CARBO), and high glucose levels derived from the dietary survey (GLU_1). Conversely, for women, the ten most pertinent variables included GLU, TRIG, WC, BMI, SBP, total proteins (PROTEI), fructose (FRUCT), high cholesterol levels as per the dietary survey (CHOL_SN), uric acid (URIC), and copper (CU).
Subsequently, we integrated the SMOTE and ADASYN techniques with RF and RPART methodologies to reevaluate the most influential features associated with MetS prediction within a balanced dataset. The extraction of features pertaining to MetS from a balanced dataset not only enhances model generalization, ensuring more even and accurate training but also leads to performance optimization while mitigating the risk of overfitting. The results highlighted striking differences between the presentations and risk factors for MetS between men and women, pointing out to the need of targeted and differentiated public health and medical interventions to cope with this syndromic disease.

Limitations

This research was based on data from a cohort of relatively healthy adult residents of Mexico City.

Author Contributions

GOGE: Conceptualization, Data Curation, Investigation, Software, Validation, Writing - original draft, Writing - review and editing; MMG: Investigation, Supervision, Data Curation, Writing - review and editing; TRR: Investigation, Software, Data Curation, Writing - review and editing; LEGM: Data Curation, Writing - review and editing; MFM: Investigation, Project Administration, Writing - review and editing; TP: Investigation, Project Administration, Writing - review and editing; LMAG: Investigation, Project Administration, Supervision, Writing - review and editing; EHL: Conceptualization, Formal Analysis, Methodology, Investigation, Funding acquisition, Writing - review and editing.

Funding

This research was supported by the National Council of Humanities, Sciences, and Technologies (CONAHCYT, México), Cátedras CONAHCYT 1591 and by Intramural funds from the National Institute of Genomic Medicine (INMEGEN, México).

Sample Availability

All relevant data is contained within the article: The original contributions presented in the study are included in the article/supplementary material; further inquiries can be directed to the corresponding author/s.

Acknowledgments

We want to extend our appreciation to Consejo Nacional de Humanidades Ciencias y Tecnología (CONAHCYT) (National Council of Humanities, Sciences, and Technologies) under the ‘Cátedras CONAHCYT’ program, No. 1591. The authors gratefully acknowledge Maite Vallejo and Tlalpan 2020 project advisory group for their logistic support in this work.

Conflicts of Interest

The authors declare no conflicts of interest.

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Figure 1. Experimental process.
Figure 1. Experimental process.
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Figure 2. The most important variables obtained through logistic regression for men and women before data balancing.
Figure 2. The most important variables obtained through logistic regression for men and women before data balancing.
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Figure 3. PCA of features of men for metabolic syndrome with clusters.
Figure 3. PCA of features of men for metabolic syndrome with clusters.
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Figure 4. Direction of variables in the PCA men.
Figure 4. Direction of variables in the PCA men.
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Table 1. Dataset variables.
Table 1. Dataset variables.
Name variable Description Type
AGE age Continuous
WEIGHT weight Continuous
HEIGHT height Continuous
BMI body mass index Continuous
WC waist Continuous
SBP systolic blood pressure Continuous
DBP diastolic blood pressure Continuous
LIV_TOG common-law marriage Dichotomous
MARRIED married Dichotomous
SINGLE single Dichotomous
DIVORC divorced Dichotomous
VALUE social development index by value Continuous
STRATUM socioeconomic stratum Continuous
QUA_HOUS quality and living space Continuous
HEALTHAC access to healthcare and social security Continuous
EDULAG educational lag Continuous
DURAB durable goods Continuous
SANITRY sanitary adequacy Continuous
ENER_AD energy efficiency Continuous
ED_LEVEL educational level in the neighborhood Continuous
SEC_SCHOOL secondary school Dichotomous
DOCTORATE doctorate Dichotomous
MASTER master Dichotomous
SCHOOL school Dichotomous
BACHELORS bachelor’s degree Dichotomous
HIGH_SCHOOL high school Dichotomous
TECH_SCHOOL technical school Dichotomous
NONE no degree Dichotomous
TOTMET metabolic Equivalent of Task Continuous
STAT_ANX state anxiety Dichotomous
TRAIT_ANX trait anxiety Dichotomous
SLPNOTQ sleep was not quiet Continuous
BREATH waking up with shortness of breath Continuous
DROWSY feel drowsy or sleepy Continuous
TROBLS trouble falling asleep Continuous
AWAKEN awaken during your sleep time Continuous
STYAWKE trouble staying awake Continuous
TAKENAP take naps of 5 minutes or longer Continuous
SLPD4 sleep disturbance Continuous
SLPSNR1 Snores during sleep Continuous
SLPSOB1 sleep short (headache) Continuous
SLPA2 sleep Adequacy Continuous
SLPS3 somnolence Continuous
SLPQRAW sleep quantity Continuous
SLPOP1 sleep quality Dichotomous
SMOKING smoking practice Dichotomous
CURRENT current smoker Dichotomous
EXSMOKER ex-smoker Dichotomous
SMO_PASS smoker passive Dichotomous
ALCOHOL alcohol consumption Dichotomous
ENERGYDRK energy drinks Dichotomous
MOTHEROB obesity mother Dichotomous
FATHEROB obesity father Dichotomous
MOTHERDB diabetic mother Dichotomous
FATHERDB diabetic father Dichotomous
MOTHERHT hypertension mother Dichotomous
MOTHERHT hypertension father Dichotomous
MOTHERDL dyslipidemia mother Dichotomous
FATHERDL dyslipidemia father Dichotomous
MOTHERGT gout mother Dichotomous
FATHERGT gout father Dichotomous
URIC uric acid Continuous
CREA creatinine Continuous
HDLCO high-density lipoprotein Continuous
LDLCO low-density lipoprotein Continuous
GLU blood glucose Continuous
IAT atherogenic index Continuous
CHOL_ANT cholesterol Continuous
TRIG triglycerides Continuous
NA sodium Continuous
CALOR energy Continuous
PROTEI total proteins Continuous
APROT proteins of animal origin Continuous
CARBO carbohydrates Continuous
SUCR sucrose Continuous
FRUCT fructose Continuous
LACT lactose Continuous
ST starch Continuous
MALT maltose Continuous
GLU_1 glucose levels based on the dietary survey Continuous
CRUDE crude fiber Continuous
SOLFB soluble dietary fiber Continuous
INSFB insoluble dietary fiber Continuous
HEMCL hemicellulose Continuous
CALC calcium Continuous
IRON total iron Continuous
MAGN magnesium Continuous
PH phosphorus Continuous
K potassium Continuous
SODIUM sodium levels based on the dietary survey Continuous
ZN zinc Continuous
CU copper Continuous
MN manganese Continuous
SE iodine Continuous
VITC vitamin C Continuous
B1 thiamine Continuous
B2 riboflavin Continuous
B6 vitamin B6 Continuous
B12 vitamin B12 Continuous
VITK vitamin K Continuous
RETINOL retinol Continuous
VITD vitamin D Continuous
VITE vitamin E Continuous
CHOL_SN cholesterol levels based on the dietary survey Continuous
ALCO alcohol levels based on the dietary survey Continuous
CAFF caffeine Continuous
AFAT animal fat Continuous
VFAT vegetable fat Continuous
TFATAV total fat: animal + vegetable Continuous
SATFAT saturated fat Continuous
MONFAT monounsaturated fat Continuous
POLY polyunsaturated fat Continuous
MS MetS Dichotomous
Table 2. Features and values obtained through logistic regression for men and women.
Table 2. Features and values obtained through logistic regression for men and women.
Women Men
Variable Coeficient P_value Variable Coeficient P_value
GLU 4.61438598 6.24E-59 GLU 3.94711748 2.45E-39
TRIG 3.63418178 1.18E-37 TRIG 2.98165065 3.25E-24
WC 1.75532078 2.86E-09 WC 2.53131848 1.02E-09
BMI 1.60919304 1.05E-06 IAT 2.06238741 5.13E-11
SBP 1.40299133 1.15E-12 SBP 1.53063308 1.31E-11
PROTEI 0.90748897 0.08529715 B12 1.41903991 0.00880359
FRUCT 0.73077934 0.23874313 BMI 1.40229014 0.00087404
CHOL_SN 0.72037259 0.06868106 LACT 1.29691863 0.00581383
URIC 0.65547784 0.01333401 CARBO 1.18935354 0.0886463
CU 0.64813271 0.17111299 GLU_1 1.1674073 0.10024746
Table 3. Features of men obtained using RF with SMOTE and ADASYN applied.
Table 3. Features of men obtained using RF with SMOTE and ADASYN applied.
ADASYN - B = 1 ADASYN - B = 5 SMOTE - K = 1 SMOTE - K = 5
Features Value Features Value Features Value Features Value
BMI 92.9499 ENER_AD 130.906694 MOTHERDL 204.657628 BMI 289.868211
WEIGHT 49.4782 BMI 104.213511 ALCOHOL 199.602686 MOTHERDL 172.071267
ENER_AD 48.8887 WEIGHT 81.5087781 BMI 198.579371 WEIGHT 169.929592
EDULAG 45.2797 EDULAG 67.7406035 SLPSOB1 111.323472 ALCOHOL 131.283664
LIV_TOG 33.3601 ALCOHOL 62.4379604 CURRENT 95.3509822 IAT 93.2909179
DURAB 31.5583 STRATUM 57.134903 BREATH 80.8262246 CHOL_ANT 63.4703128
MOTHERGT 27.5583 ED_LEVEL 55.578244 SLPD4 70.1756789 NA 49.2933568
IAT 25.7470 NONE 38.1101529 CAFF 68.9892898 CREA 45.8846962
HEALTHAC 23.4522 DURAB 36.4129389 SLP6 60.2949079 SINGLE 44.6897663
DIVORC 20.1163 VALUE 36.0130176 WEIGHT 56.9297661 SLPSNR1 35.672622
QUA_HOUS 17.4925 DIVORC 35.8243538 TOTMET 52.4806201 MOTHERDB 35.21356
STRATUM 16.1269 FATHERGT 33.7033121 ALCO 45.7609412 ENERGYDRK 34.0359073
FATHERGT 14.5872 MASTER 29.8751736 AWAKEN 39.0795326 URIC 31.8268793
NONE 14.0213 PRIMARIA 28.3852397 IAT 38.042823 AGE 27.9839119
MARRIED 13.9584 SLPSNR1 27.9671847 TROBLS 36.7528999 MARRIED 27.8864259
VALUE 13.8059 AGE 24.3706018 STYAWKE 36.2387269 DOCTORATE 24.4733499
URIC 13.7930 IAT 22.0506592 MALT 34.3472852 DIVORC 24.142464
SANITRY 13.5609 SANITRY 21.924077 BACHELORS 33.7934562 SLPOP1 23.8868609
SINGLE 13.4148 SINGLE 21.7818986 MARRIED 32.6228111 SEC_SCHOOL 22.755325
ALCOHOL 12.9798 DOCTORATE 19.8069099 SLP9 31.0845509 SLPQRAW 20.666244
Table 4. Features of men obtained using RPART with SMOTE and ADASYN applied.
Table 4. Features of men obtained using RPART with SMOTE and ADASYN applied.
ADASYN - B = 1 ADASYN - B = 5 SMOTE - K = 1 SMOTE - K = 5
Features Value Features Value Features Value Features Value
LIV_TOG 447.069761 BMI 683.735277 BMI 185.940586 BMI 164.086828
BMI 402.975487 ENER_AD 619.998675 WEIGHT 131.361866 WEIGHT 132.276557
ENER_AD 338.664389 EDULAG 565.325738 FATHERGT 115.496204 IAT 131.937059
EDULAG 325.498647 ALCOHOL 355.970533 MOTHERDL 96.1708037 SINGLE 83.6531675
DURAB 285.861702 WEIGHT 295.254303 IAT 67.2839991 MOTHERDL 71.6947353
SLP6 64.2112969 DIVORC 214.489844 AGE 40.9532174 APROT 47.2274885
WEIGHT 33.1175418 NONE 200.599299 LACT 28.7681412 TFATAV 22.4867652
IAT 27.5407406 MOTHERGT 178.450647 MOTHERHT 25.3414479 ST 20.7519258
FATHEROB 14.5734264 PROTEI 14.5865884 HEALTHAC 19.7752349
SLPSNR1 13.7361635 CAFF 14.1658755 SATFAT 17.5962564
ZN 12.4515539 HEIGHT 16.3718359
MN 12.20696 CHOL_ANT 15.4222905
IRON 10.5317678 MONFAT 13.9908309
VALUE 10.2017285 CREA 13.6358167
STYAWKE 10.1887194 URIC 11.0085972
MONFAT 10.0410598 AGE 10.5421496
CHOL_ANT 9.78675973 CALC 10.0034374
ST 9.41791645 SMOKING 9.53883547
SINGLE 9.40405705 LACT 9.34161011
SOLFB 7.74765092 TOTMET 9.09355989
Table 5. Features of women obtained using RF with SMOTE and ADASYN applied.
Table 5. Features of women obtained using RF with SMOTE and ADASYN applied.
ADASYN - B = 1 ADASYN - B = 5 SMOTE - K = 1 SMOTE - K = 5
Features Value Features Value Features Value Features Value
BMI 208.269603 ENER_AD 344.249674 WEIGHT 321.316267 BMI 484.307061
IAT 151.849516 BMI 210.90055 IAT 294.958989 IAT 481.475021
WEIGHT 98.3094923 IAT 173.895403 BMI 253.281611 WEIGHT 339.174822
EDULAG 98.0933243 ALCOHOL 146.230976 EXSMOKER 246.78181 URIC 142.754087
LIV_TOG 82.4204188 DURAB 142.91494 MASTER 241.332636 SLPSNR1 92.0496746
ENER_AD 80.7154997 EDULAG 142.817907 FATHERDL 211.443455 CHOL_ANT 74.3706077
URIC 60.4722703 WEIGHT 128.038926 CREA 170.195583 AGE 72.769531
VALUE 53.5122927 VALUE 80.989846 MOTHERHT 125.867318 SLPSOB1 70.1959444
DURAB 48.2486067 NONE 76.4699068 SLPSOB1 125.384246 BREATH 60.3028803
QUA_HOUS 37.8080123 QUA_HOUS 62.8303545 SMO_PASS 86.2763209 TRAIT_ANX 56.4099594
SLPSNR1 31.399627 BACHELORS 56.0706757 BREATH 83.1176663 SMO_PASS 50.8288614
HEALTHAC 30.6724986 SANITRY 52.5802813 CHOL_ANT 78.8668934 SANITRY 50.3648334
SANITRY 24.2597947 HEALTHAC 45.9188536 SMOKING 57.7946015 MOTHERDL 50.0567677
ALCOHOL 24.2064626 URIC 43.8531276 TRAIT_ANX 57.3909833 DROWSY 44.564559
AGE 21.594859 SINGLE 39.5694722 SLPSNR1 51.1574483 SMOKING 44.5264858
SINGLE 18.0193809 DIVORC 37.3860944 NA 50.3156936 SINGLE 41.993735
HIGH_SCHOOL 17.1684616 AGE 33.8392029 MARRIED 48.4664641 EXSMOKER 38.9120379
SLP6 16.0530682 TECH_SCHOOL 32.4092154 SLPOP1 48.3006717 SEC_SCHOOL 38.4719692
SOLFB 14.4271683 SCHOOL 28.2955057 SLPNOTQ 35.6761924
FATHERGT 13.8839264 MARRIED 27.6425229
Table 6. Features of women obtained using RPART with SMOTE and ADASYN applied.
Table 6. Features of women obtained using RPART with SMOTE and ADASYN applied.
ADASYN - B = 1 ADASYN - B = 5 SMOTE - K = 1 SMOTE - K = 5
Features Value Features Value Features Value Features Value
BMI 664.323812 BMI 1164.1686 BMI 427.45413 IAT 483.233069
LIV_TOG 535.392713 DURAB 1117.88127 IAT 363.893488 BMI 410.367827
ENER_AD 507.53479 ENER_AD 1090.27197 SLPSNR1 259.475806 WEIGHT 409.777127
EDULAG 505.45874 EDULAG 772.049538 SLPS3 259.475806 URIC 278.65513
IAT 468.310602 ALCOHOL 655.016952 EXSMOKER 217.54026 SLPSNR1 86.0218576
NONE 533.217568 SMOKING 31.3976405
IAT 380.443927 SLPS3 30.5201011
WEIGHT 366.577281 SODIUM 15.7251124
VALUE 104.231729 ALCOHOL 12.4735987
TECH_SCHOOL 92.1094015 SATFAT 12.1523683
MONFAT 12.1446951
NA 11.2712045
VITE 10.3455105
CHOL_ANT 9.04441276
FATHERDB 8.09870623
SUCR 7.16739885
MARRIED 6.39473684
FRUCT 4.94398493
MALT 4.8372105
Table 7. Results of the random forest models applying SMOTE and ADASYN in men and women.
Table 7. Results of the random forest models applying SMOTE and ADASYN in men and women.
Sex Subset Parameters Balanced accuracy (%) Sensitivity (%) Specificity (%)
Men ADASYN, B = 1 Mtry = 9 86.22 90.93 81.50
Ntree = 200 ± 0.26 ± 0.60 ± 0.41
Men ADASYN, B = 5 Mtry = 8 85.56 87.85 83.26
Ntree = 200 ± 0.34 ± 0.49 ± 0.55
Men SMOTE, K = 1 Mtry = 10 82.86 91.51 74.21
Ntree = 200 ± 1.66 ± 0.68 ± 3.45
Men SMOTE, K = 5 Mtry = 10 75.43 90.48 60.39
Ntree = 100 ± 1.29 ± 0.95 ± 2.50
Women ADASYN, B = 1 Mtry = 10 87.12 91.10 83.15
Ntree = 200 ± 0.25 ± 0.40 ± 0.29
Women ADASYN, B = 5 Mtry = 10 86.73 88.62 84.84
Ntree = 300 ± 0.20 ± 0.24 ± 0.36
Women SMOTE, K = 1 Mtry = 10 82.55 90.48 74.62
Ntree = 300 ± 0.71 ± 0.39 ± 1.46
Women SMOTE, K = 5 Mtry = 10 88.50 91.91 85.10
Ntree = 300 ± 0.40 ± 0.42 ± 0.75
Table 8. Results of the RPART models applying SMOTE and ADASYN in men and women.
Table 8. Results of the RPART models applying SMOTE and ADASYN in men and women.
Sex Subset Parameters Balanced accuracy (%) Sensitivity (%) Specificity (%)
Men ADASYN, B = 1 cp = 0.05 82.14 81.57 82.71
± 1.75 ± 3.38 ± 2.07
Men ADASYN, B = 5 cp = 0.05 82.32 82.87 81.77
± 0.99 ± 4.67 ± 5.02
Men SMOTE, K = 1 cp = 0.001 75.41 73.09 77.73
± 2.78 ± 4.07 ± 5.36
Men SMOTE, K = 5 cp = 0.002 74.67 71.96 77.38
± 2.78 ± 4.07 ± 5.36
Women ADASYN, B = 1 cp = 0.05 78.90 69.96 87.84
± 0.31 ± 0.00 ± 0.62
Women ADASYN, B = 5 cp = 0.05 78.90 69.96 87.84
± 0.31 ± 0.00 ± 0.62
Women SMOTE - K = 1 cp = 0.001 80.86 79.85 81.87
± 1.91 ± 3.79 ± 3.57
Women SMOTE - K = 5 cp = 0.005 84.49 84.20 84.79
± 1.43 ± 3.01 ± 2.51
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