Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Lipid Profile in Children Born Small for Gestational Age

Justyna Zamojska
* ORCID logo ,
Katarzyna Niewiadomska-Jarosik
,
Beata Kierzkowska
,
Marta Gruca
ORCID logo ,
Agnieszka Wosiak
ORCID logo ,
Elżbieta Smolewska
Version 1 : Received: 14 September 2023 / Approved: 14 September 2023 / Online: 14 September 2023 (14:05:20 CEST)

A peer-reviewed article of this Preprint also exists.

Zamojska, J.; Niewiadomska-Jarosik, K.; Kierzkowska, B.; Gruca, M.; Wosiak, A.; Smolewska, E. Lipid Profile in Children Born Small for Gestational Age. Nutrients 2023, 15, 4781, doi:10.3390/nu15224781. Zamojska, J.; Niewiadomska-Jarosik, K.; Kierzkowska, B.; Gruca, M.; Wosiak, A.; Smolewska, E. Lipid Profile in Children Born Small for Gestational Age. Nutrients 2023, 15, 4781, doi:10.3390/nu15224781.

Abstract

Background: Lipid disorders are one of risk factors for cardiovascular diseases. The aim of the study was to determine the lipid profile in early childhood in the group of Polish children born small for gestational age (SGA). Materials and Methods: The study included 140 children (93 SGA and 47 controls) aged 5 to 11 years. All children underwent a physical examination and blood tests for the glucose and lipid profile. SGA group was divided in subgroups: symmetrical and asymmetric intrauterine growth restriction (IUGR). Results: Blood sample analysis revealed higher levels of total cholesterol levels (SGA group 190.61 +/- 24.66 mg/dl vs control 143.23 +/- 23.90; p<0.001). The analysis of particular fractions of cholesterol showed significantly higher mean values of triglycerides, LDL-cholesterol as well as lower mean values of HDL-cholesterol in children born as SGA. Children in both groups did not differ significantly according to weight and body mass index. A statistically significantly higher glucose concentration was obtained in the group of children with IUGR with symmetrical type of IUGR. Conclusions: Children born SGA even in their early childhood, without overweight or obesity, have abnormal lipid profile, which may be a risk factor of cardiovascular diseases in adulthood.

Keywords

children; lipid profile; cholesterol; small for gestational age

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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