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Preprint ARTICLE | doi:10.20944/preprints202309.0886.v1

The Periodicity of Nuclear Magnetic Moments and Nucleon Binding Energies in Light Nuclides: Implications for Nuclear Structure

Ray Walsh

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: nuclear periodicity; nuclear structure; shell model; nucleon pairing effect; quark structure; representational nuclear chemistry; nucleon binding energy; nuclear magnetic moment

Online: 13 September 2023 (11:13:57 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202107.0633.v1

Biofortification - Associated Costs and Finding Alternatives?

Avik Ray

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Biofortification; Agro-biodiversity; HarvestPlus; Hidden Hunger; Orphan Crops; Wild edibles

Online: 28 July 2021 (16:18:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0601.v1

Successful Aging and Chronic Osteoarthritis

Ray Marks

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: aging; disability; healthy aging; osteoarthritis; pain, rehabilitation, successful aging

Online: 30 July 2018 (22:20:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1211.v1

A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

Melvin Ray Hayden

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Diabetic cerebral microvascular disease; Enlarged perivascular spaces; Glymphatic system; Neurovascular unit; Perisynaptic astrocyte endfeet; Perivascular astrocyte endfeet; Pervascular spaces; Perivascular unit; Postcapillary venule

Online: 15 December 2023 (18:12:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0170.v1

Evaulation of a Model for Urban Vegetation Barriers’ Effects on Air Pollution

Ray F. Nassar

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Air pollution; environmental hazards; Volatile Organic Compounds

Online: 8 January 2021 (16:59:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0352.v1

Proteins Nsp12 and 13 of SARS-CoV-2 Have Mitochondrial Recognition Signal: A Connection with Cellular Mitochondrial Dysfunction and Disease Manifestation

Upasana Ray, Feroza Begum

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; ARDS; non-structural proteins; mitochondria

Online: 29 June 2020 (10:40:07 CEST)

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Preprint TECHNICAL NOTE | doi:10.3390/sci2020030

On Singular Perturbation of Neutron Point Kinetics in the Dynamic Model of a PWR Nuclear Power Plant

Xiangyi Chen, Asok Ray

Subject: Physical Sciences, Applied Physics Keywords: PWR nuclear power plants; point kinetics; singular perturbation

Online: 26 April 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0374.v2

On Soft Lebesgue Measure

Sujay Goldar, Subhasis Ray

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Soft Set, Soft Element, Soft Real Number, Soft Interval, Soft Sequence, Soft Lebesgue Measure.

Online: 8 December 2022 (07:52:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0115.v1

Internet of Things Aware Secure Dew Computing Architecture for Distributed Hotspot Network: A Conceptual Study

Partha Pratim Ray, Karolj Skala

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Dew computing; Internet of Things; Blockchain; Hotspot Network

Online: 5 August 2022 (03:46:27 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202102.0618.v1

The Concept of Training Image-Based Geostatistics for Spatial Distribution of Hydraulic Conductivity

Fiaz Hussain, Ray-Shyan Wu

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Interpolation; Hydraulic Conductivity; Multi-Point Geostatistics; Training Image

Online: 26 February 2021 (12:47:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2066.v1

All-Optical, Air-Coupled Ultrasonic Detection of Low-pressure Gas Leaks and Observation of Jet Tones in the MHz Range

Kyle G. Scheuer, Ray G. DeCorby

Subject: Physical Sciences, Acoustics Keywords: jet tone; leak detection; air-coupled ultrasound; optical ultrasound detection; optomechanics; buckled dome microcavity

Online: 30 May 2023 (07:30:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0278.v1

Utilization of Mosque as A Part of Early Warning Systems to Reduce Flood Damage in Samarinda City, Indonesia

Riyan Benny Sukmara, Ray Shyan Wu

Subject: Engineering, Civil Engineering Keywords: flooding, early warning, damage, mosque

Online: 10 March 2021 (13:01:45 CET)

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Samarinda City is one of the most attractive cities in Borneo Island (Indonesia) and also as a capital city of EastBorneo Province. The expansion of urban areas becomes essential due to rapid population and housing demand. Base on the statistical report, the annual population growth rate is 0.018% from the year 2016-2017 with a total population of 843446 inhabitants. Many natural disasters occur in some areas in this city, especially flooding. This natural disaster occurs almost every year, many people suffered and forced to evacuate. In 2018 there is 3 flood event with 28311 people was suffered and evacuated, and 5170 houses were flooded [1]. During the flood event, it was very possible to gain damages to their property and make traffic stuck. One common way to reducing the damages is using Early Warning Systems (EWS). Early warning is a major element for disaster risk reduction, including damages. To prevent and mitigate the impact of a disaster, many countries had taken action to build various methods of a public warning system. An effective early warning system focused on people-centered and comprises the following element, such as risk knowledge, technical monitoring and service, communication and dissemination of warnings, and community response capability [2]. Related to the existing condition which Samarinda is a Muslim-dominated city and obviously has a lot of a number of mosques. This is a good potency to develop an early warning system because every mosque has a loudspeaker for echoing Adzan (Muslim prayer-calling). With this existing condition, the loudspeaker can be utilized as a flood outdoor-voice warning announcer. The aim of this study is to briefly introduce the strategy of dissemination early warning by utilizing mosques. The hope of early warning dissemination is giving enough time to the people to evacuate their property to reduce damages and possibly to giving information to avoiding traffic stuck (in a certain location)due to flooding. The results of this study can be used as input for decision-makers to develop effective flood management strategies and policies, especially in the case of an early warning system where not well-developed in Samarinda.

Preprint REVIEW | doi:10.20944/preprints201706.0078.v1

On-chip High-finesse Fabry-Perot Microcavities for Optical Sensing and Quantum Information

Mohammad H. Bitarafan, Ray G. DeCorby

Subject: Physical Sciences, Optics And Photonics Keywords: Fabry-Perot microcavities; sensing; cavity QED; microcavity lasers

Online: 16 June 2017 (10:38:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0587.v1

Women of Color in the Health Professions: A Scoping Review of the Literature

Olihe Okoro, Omolayo Umaru, Meghana Ray

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Intersectionality; Healthcare professions; Women of color; Pharmacy; Racial/Ethnic inequity; Gender inequity; Discrimination; Professional advancement; Underrepresentation

Online: 9 November 2023 (07:29:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0351.v1

BCG Vaccination Strategy for Preventaion against COVID-19: Hype or Hope?

Keshav Rajarshi, Aroni Chatterjee, Shashikant Ray

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; BCG immunization; SARS-CoV-2; immunity and tuberculosis

Online: 19 April 2020 (13:55:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0281.v2

Mutation Hot Spots in Spike Protein of SARS-CoV-2 Virus

Feroza Begum, Arup Kumar Banerjee, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; S protein; RBD; S1; S2

Online: 7 September 2020 (04:15:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0068.v1

Researcher Conduct Determines Data Reliability

Mark N. Wass, Larry Ray, Martin Michaelis

Subject: Social Sciences, Behavior Sciences Keywords: reproducibility crisis; replication crisis; data reliability; bias; publication bias; meta-research

Online: 5 April 2018 (10:54:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2216.v1

Impact of Cooperation and Intra-Specific Competition of Prey on the Stability of Prey-Predator Models with Refuge

Soumyadip Pal, Fahad Al Basir, Santanu Ray

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Mathematical modeling; Bifurcation analysis; Global stability; Direction of Hopf bifurcation; Numerical simulations

Online: 31 May 2023 (10:42:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0136.v1

Nonsingular phantom cosmology in Five Dimensional f(R,T) Gravity

Rakesh Ranjan Sahoo, Kamal Lochan Mahanta, Saibal Ray

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Phantom energy; LRS Bianchi type-I; $f(R,T)$ theory; $5d$ spacetimes

Online: 8 August 2022 (08:11:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0524.v1

Flood Management in Samarinda, Indonesia: Recent Progress

Riyan Benny Sukmara, Ray Shyan Wu, Ariyaningsih Ariyaningsih

Subject: Engineering, Automotive Engineering Keywords: urban flooding; flood management; flood disaster; Samarinda;

Online: 23 February 2021 (15:46:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0113.v1

Vehicle PEPS System with Intelligent Internet of Things

Ray-I Chang, Tzu-Chieh Lin, Jeng-Wei Lin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Passive Entry Passive Start; Smart Watch; Electrocardiogram; Long Short-Term Memory; Auto Encoder; Collective Decision

Online: 4 December 2023 (04:26:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0223.v1

DeSci - Decentralized Science

Jens Ducrée, Martin Codyre, Ray Walshe, Sönke Barting

Subject: Engineering, Control And Systems Engineering Keywords: digitization; virtualization; digital twin; blockchain; crowdsourcing; decentralization; non-fungible token; NFT; smart contract; oracle; tokenization; digital ownership; consensus; governance; trust; incentivization; staking; reputation systems; reproducibility crisis; exponentiality; digital twin; metaverse; DeSci; decentralized science; citizen science; open science; distributed ledger; digital scarcity

Online: 17 May 2022 (05:50:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0309.v1

Identification of Long-term Behavior of Natural Circulation Loops: A Thresholdless Approach from an Initial Response

Chandrachur Bhattacharya, Ritabrata Saha, Achintya Mukhopadhyay, Asok Ray

Subject: Computer Science And Mathematics, Mathematics Keywords: Natural circulation loops; Symbolic time series analysis; Early detection of anomalous events

Online: 18 January 2021 (09:52:01 CET)

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Preprint REVIEW | doi:10.20944/preprints201908.0057.v1

Hijacking the Host Immune Cells by Dengue Virus: Molecular Interplay of Receptors and Dengue Virus Envelope

Feroza Begum, Sandeepan Das, Debica Mukherjee, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: DENV; tropism; receptors; entry; immune cells

Online: 5 August 2019 (08:14:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0372.v1

Geodesic structure of generalized Vaidya spacetime through the K-essence

Bivash Majumder, Maxim Khlopov, Saibal Ray, Goutam Manna

Subject: Physical Sciences, Theoretical Physics Keywords: Geodesic structure; Euler-Lagrange equation; K-essence geometry; Vaidya spacetime

Online: 6 November 2023 (16:32:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0847.v1

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential

Junjiang Fu, Saber Imani, Mei-Yi Wu, Ray-Chang Wu

Subject: Biology And Life Sciences, Life Sciences Keywords: microRNA; miR‐34; tumor suppressor; miRNA therapy

Online: 10 August 2023 (10:53:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0038.v1

Coastal Upwelling in the western Bay of Bengal: Role of Local and Remote Windstress

Sthitapragya Ray, Debadatta Swain, M. M. Ali, Mark A. Bourassa

Subject: Environmental And Earth Sciences, Oceanography Keywords: Coastal upwelling; Upwelling index; Scatterometer; Wind stress; Kelvin Wave; Ekman Transport

Online: 2 September 2022 (09:57:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0061.v1

Coastal Upwelling in the Bay of Bengal: Role of Local and Remote Windstress

Sthitapragya Ray, Debadatta Swain, M. M. Ali, Mark A. Bourassa

Subject: Environmental And Earth Sciences, Oceanography Keywords: Coastal upwelling; Upwelling index; Scatterometer; Wind stress; Kelvin Wave; Ekman Transport

Online: 5 July 2022 (05:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0052.v1

A Study of McVittie Spacetime in Stationary and Dynamical Regime

Indranath Bhattacharyya, Saibal Ray, Riju Nag, Samudra Sundar Nag

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Einstein equations; McVittie solution; black hole; dark energy; embedded spacetime

Online: 6 June 2022 (03:17:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0305.v1

Strategies to Increase Prediction Accuracy in Genomic Selection of Complex Traits in Alfalfa (Medicago sativa L.)

Cesar A Medina, Harpreet Kaur, Ian Ray, Long-Xi Yu

Subject: Biology And Life Sciences, Plant Sciences Keywords: Genomic selection; WGBLUP; Medicago sativa

Online: 21 October 2021 (12:35:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0083.v1

Communicating about Sex Is Important in Generating Positive Perceptions about One’s Sexual and Romantic Life. The Last Decade Has Provided Insight into the Theoretical Applications on Sex Communication Research. While the Focus on Extant Research Focuses

Andre Fedd, Jennifer Anne Samp, Colter Ray

Subject: Social Sciences, Gender And Sexuality Studies Keywords: Sex Talk, Communicative Processes, Theory Development, Interpersonal Relationships, Sexual Behaviors

Online: 4 March 2024 (09:52:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0147.v1

A Comparative Analysis of the Proteins and Lipids in Breast, Leg, and Thigh Meats of a Commercial Domesticated Turkey

W. Keith Ray, Sherry B. Hildreth, Judith M. Jervis, Richard F. Helm

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glycolysis; lipidome; meat; mitochondria; oxidation; proteome; turkey

Online: 23 November 2017 (03:11:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0013.v1

Anisotropic Universes Sourced by Modified Chaplygin Gas

Saibal Ray, Sunil Tripathy, Rikpratik Sengupta, Bibhudutta Bal, Sonali Rout

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Anisotropic universe; Modified Chaplygin gas; Cosmological constant; Deceleration parameter

Online: 1 August 2023 (13:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0313.v3

Small-Object Detection in Remote Sensing Images with End-to-End Edge-Enhanced GAN and Object Detector Network

Jakaria Rabbi, Nilanjan Ray, Matthias Schubert, Subir Chowdhury, Dennis Chao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: object detection; faster region-based convolutional neural network (FRCNN); single-shot multibox detector (SSD); super-resolution; remote sensing imagery; edge enhancement; satellites

Online: 29 April 2020 (13:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1444.v1

zk-DASTARK: A quantum-resistant, data authentication and zero-knowledge proof scheme for protecting data feed to smart contracts

Usama Habib Chaudhry, Razi Arshad, Ayesha Khalid, Indranil Gosh Ray, Mehdi Hussain

Subject: Computer Science And Mathematics, Information Systems Keywords: Decentralized Applications; Authenticated Data; Blockchain; Smart Contract; Privacy; Zero Knowledge Proof; zk-STARK; Quantum-Resistant

Online: 19 December 2023 (11:28:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0450.v1

Novel Mutations in the S1 domain of COVID 19 Spike Protein of Isolate from Gujarat Origin, Western India

Arup Kumar Banerjee, Feroza Begum, Dluya Thagriki, Prem Prakash Tripathi, Upasana Ray

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; S protein; RBD; S1; S2; Mutation

Online: 24 April 2020 (14:19:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0169.v1

The Presence of Toxic and Non-toxic Cyanobacteria in the Sediments of the Limpopo River Basin: Implications for Human Health

Murendeni Magonono, Paul Johan Oberholster, Shonhai Addmore, Makumire Stanley, Jabulani Ray Gumbo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: cyanobacteria; cyanotoxins; nutrient enrichment; akinetes; harmful algal blooms; PCR; phylogenetic analyses

Online: 10 May 2018 (15:37:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0099.v1

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance

Joshua Yi Yeo, Ghin Ray Goh, Chinh Tran-To Su, Samuel Ken-En Gan

Subject: Biology And Life Sciences, Virology Keywords: retroviruses; HIV-1; reverse transcriptase; mutation rate; drug resistance, allostery

Online: 7 February 2020 (11:50:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0169.v1

Non-Invasive Detection Method for Recycled Flash Memory Using Timing Characteristics

Sadman Sakib, Preeti Kumari, B. M. S. Bahar Talukder, Md Tauhidur Rahman, Biswajit Ray

Subject: Engineering, Electrical And Electronic Engineering Keywords: counterfeiting; recycled flash memory; recycled flash memory detection

Online: 10 July 2018 (11:07:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0957.v1

Fundamental Components and Principles of Supervised Machine Learning Workflows with Numerical and Categorical Data

Styliani I. Kampezidou, Archana Tikayat Ray, Anirudh Prabhakara Bhat, Olivia J. Pinon Fischer, Dimitri N. Mavris

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine learning workflow; Supervised learning; Numerical data; Categorical data; Data engineering; Extraction, loading, transformation; Feature engineering; Automated feature extraction; Machine learning engineering; Training, validation, evaluation; Test-driven development; Automated machine learning; Model deployment

Online: 13 December 2023 (08:00:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0077.v1

aeroBERT-Classifier: Classification of Aerospace Requirements using BERT

Archana Tikayat Ray, Bjorn F. Cole, Olivia J. Pinon Fischer, Ryan T. White, Dimitri N. Mavris

Subject: Computer Science And Mathematics, Computer Science Keywords: Requirements Engineering; Natural Language Processing; NLP; BERT; Requirements Classification; Text Classification

Online: 6 February 2023 (02:26:56 CET)

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Preprint REVIEW | doi:10.20944/preprints201805.0416.v1

From Host to Phage Metabolism: Hot Tales of Phage T4’s Takeover of E. coli

Elizabeth Kutter, Daniel Bryan, Georgia Ray, Erin Brewster, Bob Blasdel, Burton Guttman

Subject: Biology And Life Sciences, Virology Keywords: bacteriophage; Tevenvirinae; radiolabeling; genomic map; 2-D polyacrylamide gel electrophoresis; NEPHGE-SDS PAGE

Online: 29 May 2018 (08:31:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0279.v1

Microring Distributed Sensors Using Electron Cloud Generated by Four-point Probe Sagnac Interferometer

Anita Garhwal, Arumona Edward Arumona, Kanad Ray, Phichai Youplao, Ghanshyam Singh, Preecha Yupapin

Subject: Engineering, Electrical And Electronic Engineering Keywords: distributed sensors; Sagnac interferometer; microring sensors; electron cloud sensors

Online: 11 February 2021 (11:05:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1445.v1

Increased PIEZO1 expression is associated with worse clinical outcomes in hormone receptor negative breast cancer patients

Rylee Ann Poole, Qingfei Wang, Alo Ray, Kazuaki Takabe, Mateusz Opyrchal, Eriko Katsuta

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ion channels; hormone receptor negative breast cancer; PIEZO; mechano-signaling

Online: 19 December 2023 (11:32:33 CET)

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PIEZO1 plays a crucial role in the human body as a mechanosensory ion channel. It has been demonstrated that PIEZO1 is important in tissue development and regulating many essential physiological processes. Studies have suggested that the PIEZO1 ion channel plays a role in invasion and progression in cancer; elevated levels of PIEZO1 have been correlated with increased migration in breast cancer cells, chemo-resistance and invasion in gastric cancer cells, and increased invasion of osteosarcoma cells. In addition, high PIEZO1 expression levels were correlated with a worse prognosis in glioma patients. On the other hand, studies in lung cancer have attributed high PIEZO1 levels to better patient outcomes. However, the clinical impact of PIEZO1 in breast cancer is not well characterized. Therefore, our goal was to determine the clinical relevance of PIEZO1 in breast cancer. Analysis of breast cancer data from The Cancer Genome Atlas (TCGA) was conducted to investigate PIEZO1 expression levels and correlation to survival, followed by validation in an independent dataset, GSE3494. We also performed gene set enrichment analysis (GSEA) and analyzed immune cell levels in breast tumors from TCGA through a CIBERSORT algorithm. Our results demonstrated that PIEZO1 expression levels are higher in hormone receptor (HR) negative than HR positive cohorts. High PIEZO1 expression is correlated with a significant decrease in survival in HR negative cohorts, suggesting that PIEZO1 could be utilized as a prognostic biomarker in HR negative breast cancer. GSEA showed that various signaling pathways associated with more invasive phenotypes and resistance to treatments, including epithelial-mesenchymal transition (EMT), hypoxia, and multiple signaling pathways, are enriched in high PIEZO1 HR negative tumors. Our results also demonstrated a decrease in CD8+ and CD4+ T cell infiltration in high PIEZO1 HR negative tumors. Further investigations are necessary to elucidate the mechanistic roles of PIEZO1 in HR negative breast cancer.

Preprint ARTICLE | doi:10.20944/preprints202008.0723.v1

Study on Anisotropic Strange Stars in f(T,T) Gravity

Ines G. Salako, M. Khlopov, Saibal Ray, M.Z. Arouko, Pameli Saha, Ujjal Debnath

Subject: Physical Sciences, Particle And Field Physics Keywords: general relativity; alternative gravity; compact stars; anisotropic fluid

Online: 31 August 2020 (10:43:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0452.v1

Molecular Basis of Kidney Defects in COVID-19 Patients

Smartya Pulai, Madhurima Basu, Chinmay Saha, Nitai P. Bhattacharyya, Arpita Ray Chaudhury, Sujoy Ghosh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; kidney disease; comorbidity; enrichment analysis; biological processes and pathways

Online: 20 July 2020 (02:50:36 CEST)

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Background: Kidney damage is considered to be one of the risk factors for severity and mortality among COVID-19 patients. However, molecular nature of such observations remains unknown. Hypothesis: Altered gene expressions due to infection and in chronic kidney disease could explain severity in COVID-19 with kidney defects. Methods: We collected gene expression data from publicly available resources Gene Expression Omnibus CKD, Enrichr for deregulated genes in SARS-CoV infected cells in vitro, DisGeNET and others and carried out enrichment analysis using Enrichr. Result: Number of common genes altered in chronic kidney disease (CKD) and SARS-CoV infected cells was 2834. Enrichment analysis revealed that biological processes related viral life cycle and growth, cytokines, immunity, interferon, inflammation, apoptosis, autophagy, oxidative stress and others were significantly enriched with common deregulated genes. Similarly, significantly enriched pathways related to viral and bacterial infections, immunity and inflammation, cell cycle, ubiquitin mediated proteolysis, signaling pathways like Relaxin signaling pathway, mTOR signaling pathway, IL-17 signaling pathway, NF-kappa B signaling pathway were enriched with the common deregulated genes. These processes and pathways are known to be related to kidney damage. DisGeNET terms enriched include and related to Dengue fever, chronic Hepatitis, measles, retroviridae infections, respiratory syncytial virus Infections and many others. Kidney dysfunction related terms ischemia of kidney, renal fibrosis and diabetic nephropathy. Conclusion: Common deregulated genes in SARS-CoV infected cells and chronic kidney disease, as well as their enrichment with molecular processes and pathways relevant for viral pathogenesis and renal dysfunctions, could explain the severity of COVID-19 with kidney disease. This observation not only provides molecular relation of severity in COVID-19 with renal dysfunctions but might also help in the management and treatment targets for these cases.

Preprint ARTICLE | doi:10.20944/preprints202006.0220.v1

Medical Education Adaptations Post COVID-19 - An Egyptian Reflection

Mohamed Hany Shehata, Enjy Abouzeid, Nourhan Wasfy, Adel Abdelaziz, Ray L. Wells, Samar A. Ahmed

Subject: Social Sciences, Education Keywords: COVID-19; online learning; new teaching and assessment methods; medical education

Online: 17 June 2020 (13:23:11 CEST)

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Coronavirus (COVID19) appears to be an inflection point that is forcing a disruption in medical education. However, it is not clear what the responses of the institutions are to this pandemic and how the adaptation of new methods may impact medical education in the post COVID-19 era. Objective: The study aims to explore how medical schools in Egypt responded to COVID-19 pandemic regarding the teaching and learning/assessment for undergraduate students. Design: A mixed method exploratory two-phase study was conducted. A survey was prepared and disseminated to a convenient non-probability sample of the medical school faculty through various social platforms. Then, a focus group guide was conducted to explore in more depth the findings. Results: The staff level of preparedness for that unexpected shift was evaluated by 55.1% of the survey participants as optimum to high and a good leadership support was reported by 70 % of them. They reported conflicting views about the proper role of medical education units but reinforced the idea of Egyptian Knowledge Bank’s crucial role in this transition. Additionally, there is a communication problem with the students that leads to their detachment. Subsequently, 84.6 % of the participants reported that their schools used alternative teaching methods for small groups, large groups, pre-clinical and clinical clerkships. However, 64.1 % of the participants identified a clinical skills teaching challenge. Although, 68.4% reported that alternative methods were used for formative assessment but absence of alternative methods for summative assessment was declared by 76.3%. Conclusions: Individuals moved faster than bodies and relied on support existing outside the universities when catastrophe happened. However, institutes which have experience in adapting modern engaging learning methods should organize a better response for crisis. Online learning should be integrated in the curriculum with a fair percentage especially in the early years of medical study.

Preprint ARTICLE | doi:10.20944/preprints202404.1283.v2

Sustainable Geoinformatic Approaches to Insurance for Small-Scale Farmers in Colombia

Ahmad Abd Rabuh, Richard M. Teeuw, Doyle Ray Oakey, Athanasios V. Argyriou, Max Foxley-Marrable, Alan Wilkins

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: deep learning; digital data poverty; disaster risk management; earth observation; extreme weather; GIS; machine learning; parametric insurance; small farms; sustainable geoinformatics.

Online: 23 April 2024 (17:17:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0192.v2

Examining the Potential of Generative Language Models for Aviation Safety Analysis: Case Study and Insights using the Aviation Safety Reporting System (ASRS)

Archana Tikayat Ray, Anirudh Prabhakara Bhat, Ryan T White, Van Minh Nguyen, Olivia J Pinon Fischer, Dimitri N Mavris

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Aviation Safety Reporting System; ASRS; Aviation Safety; Human Factors; Large Language Models; LLM; ChatGPT; Generative Language Models; GPT-3.5; aeroBERT; BERT; InstructGPT; Prompt Engineering

Online: 11 July 2023 (07:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1325.v1

Agile Methodology for the Standardization of Engineering Requirements using Large Language Models

Archana Tikayat Ray, Bjorn F Cole, Olivia J Pinon Fischer, Anirudh Prabhakara Bhat, Ryan T White, Dimitri N Mavris

Subject: Engineering, Aerospace Engineering Keywords: Requirements Engineering; Natural Language Processing; NLP; BERT; Requirements boilerplates; Model-Based Systems Engineering; MBSE; Requirements table; Large Language Models (LLMs); Transformer based language models

Online: 18 May 2023 (10:19:18 CEST)

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The increased complexity of modern systems is calling for an integrated and comprehensive approach to system design and development and in particular, a shift towards Model-Based Systems Engineering (MBSE) approaches for system design. The requirements that serve as the foundation for these intricate systems are still primarily expressed in Natural Language (NL), which can contain ambiguities and inconsistencies that hinder their direct translation into models. The colossal developments in the field of Natural Language Processing (NLP) in general and Large Language Models (LLMs) in particular can serve as an enabler for the conversion of NL requirements into semi-machine-readable requirements. This is expected to facilitate their standardization and use in a model-based environment. This paper discusses a two-fold strategy for converting NL requirements into semi-machine-readable requirements using language models. The first approach involves creating a requirements table by extracting information from free-form NL requirements. The second approach is an agile methodology that facilitates the identification of boilerplate templates for different types of requirements based on observed linguistic patterns. For this study, three different LLMs were utilized. Two of these models were fine-tuned versions of Bidirectional Encoder Representations from Transformers (BERT), specifically aeroBERT-NER and aeroBERT-Classifier, which were trained on annotated aerospace corpora. Another LLM, called flair/chunk-english, was utilized to identify sentence chunks present in NL requirements. All three language models were utilized together to achieve the standardization of requirements. To demonstrate the effectiveness of the methodologies, requirements from Parts 23 and 25 of Title 14 Code of Federal Regulations (CFRs) were employed, and a total of two, five, and three boilerplate templates were identified for design, functional, and performance requirements, respectively.

Preprint HYPOTHESIS | doi:10.20944/preprints202309.1540.v1

Concentrating Microbes from Human Urine Samples Using Paper-Based Adsorbents for Point-of-Care Molecular Assays

Isha Uttam, Sujesh Sudarsan, Rohitraj Ray, Raja Chinnappan, Ahmed Yaqinuddin, Khaled Al-Kattan, Naresh Kumar Mani

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: preconcentration; loop-mediated isothermal amplification (LAMP); Urine; microbial adhesion; hydrophobic; paper-based analytical devices (μPADs); cell surface hydrophobicity (CSH); UTI

Online: 22 September 2023 (08:46:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0113.v1

Smart Wireless Sensor Technology for Healthcare Monitoring System using Cognitive Radio Networks

Tallat Jabeen, Ishrat Jabeen, Humaira Ashraf, Ata Ullah, N.Z Jhanjhi, Rania M. Ghoniem, Sayan Kumar Ray

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Smart Sensor; Sensing System; Wearable Sensor; Health Monitoring; Encryption

Online: 2 June 2023 (02:36:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0796.v1

The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection

Thomas Ray O'Neil, Kevin Hu, Naomi Truong, Sana Arshad, Barbara Shacklett, Anthony Laurence Cunningham, Najla Nasr

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HIV-1; HSV-1/2; CD4; CD8; Vaccines; Infection; Immunity; Keratitis

Online: 31 December 2020 (12:18:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0461.v1

Present and Future Drinking Water Security and its Impacts on Maternities: A Multi-scale Assessment of Sudan

Vincent Simonin, Saeid Ashraf Vaghefi, Zeinab M. Abdelgadir, Dalya Eltayeb, Mohammed Ahmed M. Sidahmed, Jean-Pierre Monet, Nicolas Ray

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: water security; geographic accessibility; maternal health; climate change; Sahel

Online: 31 October 2022 (02:04:37 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202403.0367.v1

An HPLC Method for Separation of Delta 9 THC from Delta 8 THC

Giovanni A Ramirez, Monica Pittiglio, Tesfay T Tesfatsion, Kyle P Ray, Westley Cruces

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: tetrahydrocannabinol; HPLC; separations; compliance

Online: 6 March 2024 (13:19:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0093.v1

The Mixed Current Model of Nano-MOSFETs Considering the Effect of Horizontal and Vertical Electric Fields

Heng-Sheng Huang, Ping-Ray Huang, Mu-Chun Wang, Shuang-Yuan Chen, Shea-Jue Wang, Ching-Chuan Chou, LS Huang, Wei-Lun Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: drift current; diffusion current; mobility; nano-node; model; ALD technology

Online: 11 February 2019 (16:15:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1478.v1

Perspectives of People At-Risk on Parkinson's Prevention Research

Jessi L. Keavney, Soania Mathur, Karlin Schroeder, Ray Merr, Sergio A. Castillo-Torres, Virginia Gao, Grace F. Crotty, Michael A. Schwarzschild, John M. Poma

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson's Disease; Prevention; Risk; Patient Advocacy; Patient Engagement; REM Sleep Behavior Disorder; Hyposmia; LRRK2; GBA

Online: 20 December 2023 (10:55:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1346.v1

Unraveling the Interplay: Intestinal Parasites and Gut Microbiome in Immune-Mediated Bowel Disease

Sejuti Ray Chowdhury, Arup Dey, Sandip Mondal, Sharad D. Pawar, Anagha Ranade, Bidhan Mahajon, Manajit Bora, Chinmaya Rath, Mayank Gangwar, Manish Kumar Gautam

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Immune-mediated bowel diseases; intestinal parasites; microbiome; homeostasis; targeted therapeutic strategies.

Online: 18 August 2023 (09:21:43 CEST)

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Immune-mediated bowel diseases (IMBD), including Ulcerative colitis and Crohn's disease, represent a significant global health burden with their complex etiology and increasing prevalence. The connection between intestinal parasites and the gut microbiome in immune-mediated bowel disease is a complex and evolving field of research. Several studies have demonstrated that intestinal parasites can modulate the composition and function of the gut microbiome. Parasitic infections can result in alterations in the gut microbial community, including changes in microbial diversity, abundance, and metabolic activity. These changes can influence the immune response and contribute to the development of IMBDs. In contrast, the gut microbiome serves a pivotal function in maintaining intestinal homeostasis and immune regulation. Dysbiosis, characterized by changes in the gut microbial composition, has been associated with the pathogenesis of IMBDs. Imbalances in the gut microbiota can result in increased gut permeability, chronic inflammation, and aberrant immune responses, all of which are hallmarks of IMBDs. The bidirectional interaction between intestinal parasites and the gut microbiome further complicates the understanding of immune-mediated bowel diseases. Certain parasites, such as hookworms and Necator americanus, have been found to downregulate immune responses and may have therapeutic potential in treating celiac disease. On the other hand, infections with parasites like Strongyloides stercoralis and Blastocystis have been shown to mimic the symptoms of IBD, highlighting the intricate relationship between parasites and the pathogenesis of these diseases. Additional investigation is required to comprehensively elucidate the mechanisms that underlie the association between intestinal parasites and the gut microbiome in immune-mediated bowel disease. This knowledge could potentially lead to the development of targeted therapeutic strategies that aim to restore gut microbiota homeostasis and alleviate the symptoms of these debilitating conditions. By understanding and harnessing the complex interplay between parasites, the gut microbiome, and the host immune system, researchers may uncover novel approaches for the management and treatment of immune-mediated bowel diseases.

Preprint ARTICLE | doi:10.20944/preprints202208.0425.v1

Mycobacterium Bovis Strain Ravenel is Attenuated in Cattle

Syeda Anum Hadi, Evan P Brenner, Mitchell V Palmer, Wade Ray Waters, Tyler C Thacker, Catherine Vilcheze, Michelle H Larsen, William R Jacobs, Jr., Srinand Sreevatsan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: bovine tuberculosis; TB; attenuation; genomes; immunopathogenesis; SNPs

Online: 25 August 2022 (07:18:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0059.v1

Optimization of Lactoperoxidase and Lactoferrin Separation on an Ion-Exchange Chromatography Step

Naeimeh Faraji, Yan Zhang, Ajay K. Ray

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cation exchange chromatography; minor milk protein; response surface modeling; simulation; steric mass action (SMA); optimization

Online: 12 January 2017 (09:59:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0061.v1

Assessing Hydrological Impacts of a Watershed in the Context of Climate and Land Cover Changes

Dong-Sin Shih, Ray-Shyan Wu, Chung-Yuan Tsai

Subject: Engineering, Civil Engineering Keywords: climate change; land cover change; WASH123D

Online: 12 January 2017 (10:05:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0564.v1

Modified Power Law Cosmology: Theoretical Scenarios and Observational Constraints

Lokesh Kumar Sharma, Suresh Parekh, Kalyani C.K. Mehta, Maxim Yu. Khlopov, Saibal Ray, Anil Kumar Yadav

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: MCMC; cosmological parameters; Power Law; Observational constraints; Om Diagnostics; cosmography

Online: 9 February 2024 (13:24:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0864.v1

Assessment of Economic Sustainability of Cropping Systems in the Salt-Affected Coastal Zone of West Bengal, India

Krishnendu Ray, Suman Mandal, Md. Jahangir Kabir, Sukamal Sarkar, Kalyan Roy, Koushik Brahmachari, Argha Ghosh, Manoj K Nanda, Sanchayeeta Misra, Supriya Ghorui, Rupak Goswami, Mohammed Mainuddin

Subject: Social Sciences, Geography, Planning And Development Keywords: sustainable intensification; rice-based cropping systems; risk analysis; stochastic dominance; economic sustainability

Online: 25 April 2023 (02:31:38 CEST)

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Identifying productive, profitable and less risky cropping systems is important for sustaining farm-based livelihoods in the context of climatic uncertainties and market volatility in many developing nations. Reductionist field crop research identifies the best-bet solutions based on treatment replicates at a single point in time, which may not account for price instability under climatic uncertainties and volatile markets. Keeping this in mind, we estimated productivity, profitability and weather-related risk from eleven different rice-based cropping systems (eight existing and three potential systems) in the coastal region of West Bengal, India. Information on the crop management practices, yield and prices of the component crops of these eleven cropping systems, under ’best,’ ’normal’ and ‘worst’ situations (scenario), were collected through a ques-tionnaire survey on50 farms of Gosaba Block, West Bengal, India. Irrespective of the scenarios, the rice-lathyrus systems, followed by rice-onion and rice-lentil systems recorded the lowest rice-equivalent yields and system yields. However, the highest rice-equivalent yields and system yields were recorded for rice-chilli systems, followed by rice-tomato and rice-potato-green gram systems. Per hectare total paid-out cost (TPC) of rice-tomato systems was higher, followed by rice-chilli, rice-potato-green gram and rice-potato systems. However, irrespective of seasonal conditions (best, normal and worst), rice-chilli systems gave a higher net return followed by rice-tomato and rice-potato-green gram systems. The rice-fallow system recorded the lowest value for both parameters. Under the worst seasonal conditions, the rice-onion system gave a negative net return. Under all the scenarios, the highest B:C ratio was observed for rice-chilli, rice-tomato, rice-potato-green gram and rice-potato systems. The cumulative probability distribution of the rice-tomato system showed first-degree stochastic dominance over other systems and the rice-chilli system showed second-degree stochastic dominance over the rest of the systems. Only the rice-onion system had a small chance (< 1%) of a negative net return, while the rest of the cropping systems were highly likely to get a positive net return. Taking productivity, economics, and risk assessment of different rice-based systems into account, rice-vegetable systems, especially rice-tomato and rice-chilli among the existing systems and rice-potato-green gram system among the potential systems, can be recommended for sustainable intensification in these coastal saline tracts of the region. We also discuss additional socio-economic factors explored by in-depth in-terviews with the farmers, which might influence the adoption and upscaling of these cropping systems in the region.

Preprint ARTICLE | doi:10.20944/preprints202306.1821.v1

Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and are Predictive of Response in Locally Advanced Rectal Cancer

Stephanie H Lim, Wei Chua, Weng Ng, Emilia Ip, Tania M Marques, Nham T Tran, Margarida Gama-Carvalho, Ray Asghari, Christopher Henderson, Yafeng Ma, Paul De Souza, Kevin J. Spring

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Locally advanced rectal cancer; chemoradiotherapy; microRNA; circulating tumour cells; lymphocytes; predictive biomarkers.

Online: 26 June 2023 (14:09:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0009.v1

Self-Reported and Parent-Reported School Bullying in Adolescents with High Functioning Autism Spectrum Disorder: The Roles of Autistic Social Impairment, Attention-Deficit/Hyperactivity and Oppositional Defiant Disorder Symptoms

Wen-Jiun Chou, Ray C. Hsiao, Hsing-Chang Ni, Hsin-Yi Liang, Chiao-Fan Lin, Hsiang-Lin Chan, Yi-Hsuan Hsieh, Liang-Jen Wang, Min-Ching Li, Huei-Fan Hu, Cheng-Fang Yen

Subject: Social Sciences, Behavior Sciences Keywords: Bullying; autism spectrum disorder; attention-deficit/hyperactivity disorder; oppositional defiant disorder; social impairment.

Online: 1 March 2019 (12:24:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0306.v1

Mental Health Issues in Madhya Pradesh: Insights from National Mental Health Survey of India 2016.

Arun Kokane, Abhijit Pakhare, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, Girish Rao, Aravind B A, Mukesh Shukla, Arun Mitra, Kriti Yadav, Rajni Chatterji, Sukanya Ray, Akash Ranjan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mental disorder, treatment gap, health system, Madhya Pradesh.

Online: 30 January 2019 (09:25:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0487.v1

Estimating the Carbon Footprint of Healthcare in the Canton of Geneva and Reduction Scenarios for 2030 and 2040

Bruno Mermillod, Raphaël Tornare, Nicolas Ray, Antoine Flahault

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: carbon footprint; Geneva’s healthcare; carbon dioxide; greenhouse gas; healthcare system; sustainability

Online: 8 April 2024 (10:06:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1560.v1

A Blockchain-Based Fish Supply Chain Framework for Maintaining Fish Quality and Authenticity

Shereen Ismail, Muhammad Nouman, Hassan Reza, Fartash Vasefi, Hossein Kashani Zadeh

Subject: Computer Science And Mathematics, Security Systems Keywords: fish supply chain; blockchain; ethereum; smart contract; artificial intelligence; internet of things; traceability; fish quality; authenticity; QAT technology

Online: 26 March 2024 (13:03:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0717.v1

Molecular Characterization of Ovarian Yolk Sac Tumor (OYST)

Khalil Hodroj, Aleksandra Stevovic, Valery Attignon, Domenico Ferraioli, Pierre Meeus, Sabrina Croce, Nicolas Chopin, Lea Rossi, Anne Floquet, Christine Rousset-Jablonski, Olivier Tredan, Frédéric Guyon, Isabelle Treilleux, Corinne Rannou, Marie Morfouace, Isabelle Ray-Coquard

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: OYST; molecular characteristics; targetable mutation; patients’ outcome

Online: 30 November 2020 (11:06:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0108.v1

Bioinformatics-Based Design Strategy and Development of an Antigen Test for SARS-CoV-2 Nucleocapsid Protein

Partha Ray, Melissa Ledgerwood-Lee, Howard Brickner, Alex E. Clark, Aaron Garretson, Rishi Graham, Westley Van-Zant, Aaron F. Carlin, Eliah S. Aronoff-Spencer

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Nucleocapsid protein; Monoclonal and Polyclonal Antibodies; Enzyme-Linked Immunoassay; Peptide epitope mapping; Viral Quality Assurance; RADx; COVID-19 diagnostics

Online: 1 April 2024 (17:21:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1876.v1

FXR agonism with bile acid mimetic reduces pre-clinical triple-negative breast cancer burden

Sydney Clarice Joseph, Samson Eugin Simon, Margaret Sue Bohm, Minjeong Kim, Madeline E Pye, Boston William Simmons, Dillon Garen Graves, Stacey Marchelle Thomas-Gooch, Ubaid A Tanveer, Jeremiah Ray Holt, Suriyan Ponnusamy, Laura M Sipe, D. Neil Hayes, Katherine Loree Cook, Ramesh Narayanan, Joseph F Pierre, Liza Makowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nuclear hormone receptor, agonist, bile acid receptor, FXR, TGR5, triple-negative breast cancer, TNBC

Online: 26 January 2024 (11:49:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1052.v1

Sorafenib in Molecularly Selected Cancer Patients: Final Analysis of the MOST-Plus Sorafenib Cohort

Olivier Trédan, Maud Toulmonde, Christophe Le Tourneau, Laure Montane, Antoine Italiano, Isabelle Ray-Coquard, Christelle De La Fouchardière, François Bertucci, Anthony Gonçalves, Carlos Gomez-Roca, Benoit You, Valéry Attignon, Sandrine Boyault, Philippe Cassier, Armelle Dufresne, Séverine Tabone-Eglinger, Alain Viari, Emilie Sohier, Maud Kamal, Gwenaelle Garin, Jean-Yves Blay, David Pérol

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: personalized medicine; biologically-driven trial; sorafenib; randomised discontinuation design

Online: 15 May 2023 (14:22:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0199.v1

A Unified User-Friendly Instrument Control and Data Acquisition System for the ORNL SANS Instrument Suite

Xingxing Yao, Blake Avery, Miljko Bobrek, Lisa Debeer-Schmitt, Xiaosong Geng, Ray Gregory, Greg Guyotte, Mike Harrington, Steven Hartman, Lilin He, Luke Heroux, Kay Kasemir, Rob Knudson, James Kohl, Carl Lionberger, Ken Littrell, Matthew Pearson, Sai Venkatesh Pingali, Cody Pratt, Shuo Qian, Mariano Ruiz-Rodriguez, Sedov Vladislav, Gary Taufer, Volker Urban, Klemen Vodopivec

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: SANS; Neutron Scattering; Instrument control; Data acquisition, User facility, GUI

Online: 11 January 2021 (13:19:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1789.v1

Spectrum of Neurological Adverse Events Following COVID-19 Vaccination: An Observational Study From a Tertiary Care Centre of Eastern India

UDDALAK CHAKRABORTY, BIMAN KANTI RAY, ALAK PANDIT, SOUMITA SADHUKHAN, ARIJIT ROY, SAUMEN BHAT, AISHEE BHATTACHARYYA, Rajdeep SAHA, ARINDAM SANTRA, SUJOY KABIRAJ, AJITAVA DUTTA, DWAIPAYAN BHATTACHARYYA, MANSI DAS, SHAMBADITYA DAS, DEBALEENA MUKHERJEE, ARKA PRAVA CHAKRABORTY, PEYALEE SARKAR, SOUGATA BHATTACHARYA, RAJU AGRAWAL, GURUPADA DAS, GOUTAM GANGOPADHYAY, SAMAR BISWAS, ADREESH MUKHERJEE, ATANU BISWAS, UMA SINHA ROY, JAYANTA GHOSAL, SUMANTA SARKAR, GAUTAM DAS, SUMAN DAS, JASODHARA CHAUDHURI, SOUVIK DUBEY

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: post -vaccination neurological complications; Guillain-Barré syndrome; central nervous system demyelination; vascular events

Online: 26 September 2023 (11:10:33 CEST)

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Background: As the world tends to recover from the crisis created by the COVID-19 pandemic, vaccines have served as one of the most valuable tools of combat and large-scale immunization has helped to tide over the catastrophe. However, several reports of post -vaccination neurological complications around the globe have surfaced up in recent literature. This study was conducted with an aim to describe the spectrum of neurological ailments requiring hospitalization following COVID-19 vaccination.Methods: An ambispective observational study was carried out from March 2021 to February 2022 at a tertiary care institute with 25 patients who satisfied the inclusion criteria of a new onset neurological illness requiring hospitalization within 4 days to 42 days of vaccination. The patients were duly followed upto months after discharge.Results: The median age of the sample was 36 years and the median latency of onset of neurological events was 14 days. Guillain-Barré syndrome was documented in 11 patients; majority were acute motor axonal neuropathy (45.45%) followed by acute inflammatory demyelinating polyradiculoneuropathy (36.36%) and acute motor sensory axonal neuropathy (18.18%). Central nervous system demyelination was reported in 9 patients; two patients had acute disseminated encephalomyelitis, 2 patients were diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease, one patient with aquaporin-4 positive neuromyelitis optica spectrum disorder , and the rest were labelled as seronegative central nervous system demyelination. Vascular events were noted in 5 patients comprising of 2 cases each of cerebral venous sinus thrombosis and intracerebral hemorrhage and a case of Moyamoya angiopathy. All patients were conservatively managed and had a complete to partial recovery suggestive of a favorable outcome after 3 months. Conclusion: The pathomechanisms of post -vaccination neurological complications is yet to be elucidatedand any causal association attributable to vaccination warrants further research. Compared to the enormity of the vaccinated population, the adverse effects are miniscule to hinder and discourage vaccination.

Working Paper ARTICLE

Bringing Onco-innovation to Europe's Healthcare Systems: The Potential of Biomarker Testing, Real World Evidence, Tumour Agnostic Therapies to Empower Personalised Medicine

Denis Horgan, Gennaro Ciliberto, Pierfranco Conte, Giuseppe Curigliano, Luis Seijo, Luis M. Montuenga, Marina Garassino, Frederique Penault-Llorca, Fabrizia Galli, Isabelle Ray-Coquard, Denis Querleu, Peter Riegman, Keith Kerr, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Benedikt Westphalen, Jasmina Koeva-Balabanova, Angelo Paradiso, Zorana Maravic, Vassiliki Fotaki, Nuria Malats, Chiara Bernini, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan Van Meerbeeck, Michael Duffy, Beata Jagielska, Ettore Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers; BRCA1/2; genomics; European recommendation

Online: 18 August 2020 (16:30:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0307.v1

Bringing onco-innovation to Europe’s healthcare systems: the unexploited potential of biomarker testing, real world evidence and the potential of Tumour Agnostics. The lesson from BRCA1/2 genetic testing

Denis Horgan, Gennaro CILIBERTO, Pierfranco Conte, Giuseppe CURIGLIANO, Luis Seijo, Luis M. Montuenga, Luis Paz-Ares, Marina Chiara Garassino, Penault-Llorca Frederique, Fabrizia GALLI, Isabelle Ray-Coquard, Denis Querleu, David R. Baldwin, Susana Banerjee, Peter H.J. Riegman, Keith Kerr, Benjamin Horbach, Reinhard Büttner, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Westphalen Christoph Benedikt, Fabien CALVO, Jasmina Koeva-Balabanova, Stephen Hall, Angelo Virgilio Paradiso, Dipak. Kalra, Christa M. Cobbaert, Rocio Varea Mendez, Zorana Maravic, Vassiliki Fotaki, Jaafar Bennouna, Estelle Cauchin, Núria Malats, Iñaki Gutiérrez-Ibarluzea, Benjamin Gannon, Ken Mastris, Chiara Benini, William M. Gallagher, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan P. van Meerbeeck, Michael Joe Duffy, Elzbieta. Sarnowska, Beata Jagielska, Sarah Mee, Ettore Domenico Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers, BRCA1/2, genomics; European recommendation

Online: 14 August 2020 (04:27:45 CEST)

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