Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Mutation Hot Spots in Spike Protein of SARS-CoV-2 Virus

Version 1 : Received: 15 April 2020 / Approved: 16 April 2020 / Online: 16 April 2020 (15:30:56 CEST)
Version 2 : Received: 6 September 2020 / Approved: 7 September 2020 / Online: 7 September 2020 (04:15:59 CEST)

How to cite: Begum, F.; Banerjee, A.K.; Ray, U. Mutation Hot Spots in Spike Protein of SARS-CoV-2 Virus . Preprints 2020, 2020040281 (doi: 10.20944/preprints202004.0281.v2). Begum, F.; Banerjee, A.K.; Ray, U. Mutation Hot Spots in Spike Protein of SARS-CoV-2 Virus . Preprints 2020, 2020040281 (doi: 10.20944/preprints202004.0281.v2).

Abstract

Spike (S) protein of Coronaviruses help in receptor attachment and virus entry into the host cells. While S protein is required for virus entry, it is also important as an immunogen as it is the most accessible part of the virus architecture. S protein form knob like structures (viral spikes) protruding outwards in the form of homotrimers containing an S1 and S2 as monomers. Mutations in structural proteins of virus play crucial role in determining virulence and also in many instances influencing emergence of antibody escape variants and cellular tropism. In this paper we have performed in depth analyses of spike protein sequences from various parts of the world and tried to correlate the data with possible functional relevance of such mutations.

Subject Areas

COVID-19; SARS-CoV-2; S protein; RBD; S1; S2

Comments (1)

Comment 1
Received: 7 September 2020
Commenter: Upasana Ray
Commenter's Conflict of Interests: Author
Comment: We have done analyses on recently available and greater number of sequences. All the available full sequences from India have also been included. We included RDB mutation locations with respect to spike-ACE2 PDB structure. Hence, this is a significantly upgraded version. 
In the title COVID-19 has been replaced with SARS-CoV-2.
Feroza Begum conducted more studies and hence she has been kept as first author. AKB and UR are joint corresponding authors.
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