Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance

Version 1 : Received: 6 February 2020 / Approved: 7 February 2020 / Online: 7 February 2020 (11:50:11 CET)

A peer-reviewed article of this Preprint also exists.

Yeo, J.Y.Y.; Goh, G.R.; Su, C.-T.T.-T.; Gan, S.-E.K.-E. The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance. Viruses 2020, 12, 297. Yeo, J.Y.Y.; Goh, G.R.; Su, C.-T.T.-T.; Gan, S.-E.K.-E. The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance. Viruses 2020, 12, 297.

Journal reference: Viruses 2020, 12, 297
DOI: 10.3390/v12030297

Abstract

The high mutation rate of human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance from the development of vaccines to long-lasting drugs. In addressing the crux of the issue, various attempts to estimate the mutation rate of HIV-1 resulted in a large range of 10-5 - 10-3 errors/bp/cycle due to the use of different types of investigation methods. In this review, we discuss the different assay methods, their findings on the mutation rates of HIV-1 and how the location of these mutations can be further analyzed for their potential allosteric effects to reveal potentially new inhibitors with different pharmacodynamics that can be used to circumvent fast occurring HIV drug resistance. Given that HIV is one of the fastest mutating viruses, it is a good model for comprehensive study of its mutations that can give rise to much horizontal understanding towards overall viral drug resistance as well as emerging viral diseases.

Subject Areas

retroviruses; HIV-1; reverse transcriptase; mutation rate; drug resistance, allostery

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.