Preprint Review Version 1 This version is not peer-reviewed

From Host to Phage Metabolism: Hot Tales of Phage T4’s Takeover of E. coli

Version 1 : Received: 28 May 2018 / Approved: 29 May 2018 / Online: 29 May 2018 (08:31:59 CEST)

A peer-reviewed article of this Preprint also exists.

Kutter, E.; Bryan, D.; Ray, G.; Brewster, E.; Blasdel, B.; Guttman, B. From Host to Phage Metabolism: Hot Tales of Phage T4’s Takeover of E. coli. Viruses 2018, 10, 387. Kutter, E.; Bryan, D.; Ray, G.; Brewster, E.; Blasdel, B.; Guttman, B. From Host to Phage Metabolism: Hot Tales of Phage T4’s Takeover of E. coli. Viruses 2018, 10, 387.

Journal reference: Viruses 2018, 10, 387
DOI: 10.3390/v10070387

Abstract

The mechanisms by which bacteriophage T4 converts the metabolism of its E. coli host to one dedicated to progeny phage production was the subject of decades of intense research in many labs from the 1950’s through the 1980’s. At this point, a wide range of phages are starting to be used therapeutically and in many other applications and also the range of available phage sequence data is skyrocketing. It is thus important to re-explore the extensive available data about the intricacies of the T4 infection process as summarized here, expand it to looking much more broadly at other genera of phages, and explore phage infections using newly-available modern techniques and a range of appropriate environmental conditions.

Subject Areas

bacteriophage; Tevenvirinae; radiolabeling; genomic map; 2-D polyacrylamide gel electrophoresis; NEPHGE-SDS PAGE

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.