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Preprint ARTICLE | doi:10.20944/preprints201803.0122.v1

Accelerated Reported Battery Capacity Loss in 30 kWh Variants of the Nissan Leaf

Daniel Myall, Dima Ivanov, Walter Larason, Mark Nixon, Henrik Moller

Subject: Engineering, Energy And Fuel Technology Keywords: electric vehicle; Nissan Leaf; lithium-ion battery; capacity loss; battery degradation

Online: 15 March 2018 (07:19:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0131.v1

Forensic Analysis of the 38 Subject Deaths in the 6-Month Interim Report of the Pfizer/BioNTech BNT162b2 mRNA Vaccine Clinical Trial

Corinne Michels, Daniel Perrier, Jeyanthi Kunadhasan, Ed Clark, Joseph Gehrett, Barbara Gehrett, Kim Kwiatek, Sarah Adams, Robert Chandler, Leah Stagno, Tony Damian, Erika Delph, Chris Flowers

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BNT162b2 vaccine; Pfizer/BioNTech; cardiovascular events; COVID-19

Online: 4 September 2023 (08:19:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0397.v1

What are the Impacts of Sugarcane Production on Ecosystem Services? A Review

Daniel EL CHAMI, André DACCACHE, Maroun EL MOUJABBER

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Sugarcane, impacts, ecosystem services, human well-being, agro-systems, sustainability

Online: 27 February 2020 (10:56:50 CET)

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Since the 1950s sugarcane production has grown rapidly from less than 0.5 billion tonnes in the late 50s to reach over 1.9 billion tonnes in 2012 on about 27 million hectares of agricultural land. This expansion has been boosted by the high demand for bioethanol promoted as a sustainable bioenergy source which accounted in 2010 for the biggest share of the global biofuel market. Despite its benefits, the scientific debate on sugar is growing especially that counterarguments are so many, including negative impacts on different interacting ecosystems and human well-being, e.g. bigger stress on land and water resources, environmental externalities on air, a harmful impact on the biodiversity and endemic species, negative environmental externalities, health, and socio-economic aspects. This paper provides a narrative systematic review (SR) of the impacts of sugarcane production on these different ecosystems employing the ecosystem services framework for its acceptance by policy-makers. The references included for the SR were 163 and results showed that the majority of the studies are from Brazil, Australia, South Africa and the USA (≈ 75% of the literature), most of them were from peer-reviewed journals (85%), and most of the case studies adopted a quantitative research approach (93%). The literature assessed showed that sugarcane, like all agro-systems, depends on the practices and techniques to transform negative impacts into positive externalities on ecosystems and human well-being. However, the literature studied failed to include the inter-linkage in sugarcane production impacts’ and therefore to evaluate the related ecosystem services with respect to the Millennium Ecosystem Assessment (MA) framework to account for existing trade-offs. Therefore, the findings are addressed to the scientific community and decision-maker for an intensification of interdisciplinary and integrated research based on the MA framework to cover all ecosystem services, for sustainable development of the sugarcane sector.

Preprint ARTICLE | doi:10.20944/preprints202006.0111.v1

A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications

Jan-Peter Hauschild, Amelia Corinne Peterson, Erik Couzijn, Eduard Denisov, Denis Chernyshev, Christian Hock, Hamish Stewart, Ralf Hartmer, Dmitry Grinfeld, Christian Thoeing, Bastian Reitemeier, Arne Kreutzmann, Oliver Lange, Wilko Balschun, Aivaras Venckus, Sebastian Kanngiesser, Alexander Kholomeev, Gregor Quiring, Frank Czemper, Eloy Wouters, Michael Belford, Mathias Mueller, Jens Grote, Tabiwang N. Arrey, Julia Kraegenbring, Kerstin Strupat, Siegrun Mohring, Catharina Crone, Alexander Harder, Aaron Robitaille, Aaron Gajadhar, Khatereh Motamed, Yang Liu, Daniel Lopez Ferrer, Nicolaie Eugen Damoc, Angela Criscuolo, Kristina Srzentic, Ed George, Charles Yang, Ioanna Ntai, Amanda Souza, Andreas Wieghaus, Alexander Makarov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Orbitrap mass spectrometry; high resolution; accurate mass

Online: 8 June 2020 (10:17:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0302.v1

Focusing on the Unfolded Protein Response and Autophagy Related Pathways to Reposition Common Approved Drugs against COVID-19

Serguei Nabirotchkin, Alex E. Peluffo, Jan Bouaziz, Daniel Cohen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-2019; SARS-CoV-2; 2019-nCoV; repositioning; UPR/Autophagy; real-world evidence; pathways

Online: 20 March 2020 (03:55:55 CET)

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More than 179,000 individuals have fallen ill of the Coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus, which first emerged in China less than four months ago in December 2019. As of today, there exist no approved treatments against COVID-19. Vaccines are being developed, but they will take time, at least one year, to reach the population. Drug repositioning represents a fast track because already approved medicines have been broadly tested through multiple trials. We developed a repositioning strategy that mostly leads to candidates that are commonly used. The advantages are that they will facilitate proof of concept in humans through a “real-world evidence” approach and should be rapidly available to the population. We focus on the established research results that the unfolded protein response (UPR) and autophagy pathways of the host cells are essential to the life cycle of previously known coronaviruses. We performed the relevant bioinformatics analysis to understand and confirm if SARS-CoV-2 may interact with these druggable pathways. Based on these considerations, we prioritized two additional druggable pathways, which are important to the viral life cycle and tightly connected to UPR/autophagy signaling: the mitochondrial permeability transition pores (MPTP) and NLRP-3 inflammasome pathways. These four important pathways are perturbed in most major common diseases and have therefore been targeted by numerous broadly prescribed drugs. We have identified 97 approved drugs that are known to modulate these four identified pathways, and which represent, therefore, interesting repositioning candidates. Although it is indisputable that these drugs should never be used for immediate self-medication against COVID-19, we notice that some of them could also be prescribed to individuals who have COVID-19 comorbidities (e.g., hypertension). It is debated if these comorbidities are linked to the pathology itself (e.g., hypertension) or the drugs used to treat the pathology (e.g., sartans). Therefore, relevant preclinical tests and massive electronic health records (i.e., real-world evidence) must be used to pre-screen them and check the COVID-19 prognosis of individuals taking these drugs.

Preprint ARTICLE | doi:10.20944/preprints201807.0119.v1

Implementation of Regional-CNN and SSD Machine Learning Object Detection Architectures for the Real Time Analysis of Blood Borne Pathogens in Dark Field Microscopy

Daniel Fleury, Angelica Fleury

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Convolutional Neural Network,Single Shot Detector, Regional Convolutional Neural Network, Machine Learning, Visualization-Localization

Online: 6 July 2018 (14:38:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0286.v1

Network Bioinformatics Analysis Provides Insight into Drug Repurposing for COVID-2019

Xu Li, Jinchao Yu, Zhiming Zhang, Jing Ren, Alex E. Peluffo, Wen Zhang, Yujie Zhao, Kaijing Yan, Daniel Cohen, Wenjia Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: COVID-2019; SARS-CoV-2; repurposing; network bioinformatics

Online: 18 March 2020 (08:50:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0318.v2

Techno-Economic Feasibility of Hybrid Solar Photovoltaic and Battery Energy Storage Power System for a Soshanguve Mobile Cellular Base Station in South Africa

Banjo Ayoade Aderemi, SP Daniel Chowdhury, Thomas O. Olwal, Adnan M. Abu-Mahfouz

Subject: Engineering, Electrical And Electronic Engineering Keywords: Solar PV, Green Energy, Hybrid Power Source, Mobile Cellular Base Station, OPEX, Solar Irradiance

Online: 25 July 2018 (14:30:45 CEST)

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Over the years, sustainability, impact on the environment, as well as the operation expenditure have been a major concern to the deployment of mobile cellular base stations worldwide. This is because the mobile cellular base stations are known to consume a high percentage of power within the mobile cellular network. Such energy consumption contributes to the emission of Greenhouse Gases (GHG) through the use of conventional diesel generating a set. As a result, the mobile cellular operators are faced with the dilemma of minimising the power consumption, GHG emission, and the operation cost, while improving the Quality of Service of the networks. In attempting to find a solution, this study presents the feasibility and simulation of a solar photovoltaic (PV) with battery hybrid power system (HPS) as a predominant source of power for a specific mobile cellular base station site situated in Soshanguve area of the city of Pretoria, South Africa. It also presents the technical development, showed the environmental advantage and cost benefits of using a solar PV-battery HPS to power a base station site of a 24 hrs daily load of 241.10 kWh/d and the peak load of 20.31 kW as compared to using the HPS of solar PV-diesel generating set-battery. The solar resource pattern for the city of Pretoria was collected from The National Aeronautics and Space Administration and modelled statistically. Thus, the statistical modelling done using solar radiation resource exposure characteristic patterns of Pretoria, South Africa, revealed an average annual daily solar radiation of 5.4645 Wh/m2/d and 0.605 clearness index. The simulation and the design were done using the Hybrid Optimization Model for Electric Renewables and Matlab/Simulink software. The simulation finding shows that the HPS of solar PV-battery combination has about 59.62 % saving on Net Present Cost, Levelized Cost of Energy, and 80.87% saving on Operating cost as against conventional BS powered with Gen Set-Battery.

Preprint ARTICLE | doi:10.20944/preprints201710.0042.v1

Validity and Reliability of the Kinovea Program in Obtaining Angular and Distance Dimensions

Albert Puig-Diví, Josep Maria Padullés-Riu, Albert Busquets-Faciaben, Xavier Padullés-Chando, Carles Escalona-Marfil, Daniel Marcos-Ruiz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: free software; human motion; Kinovea; low cost; reliability; validity; video analysis

Online: 9 October 2017 (05:07:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0271.v1

Clinical Characteristics, Activity Levels and Mental Health Problems in Children with Long COVID: A Survey of 510 Children

Danilo Buonsenso, Ferran Espuny Pujol, Daniel Munblit, Sammie Mcfarland, Frances Simpson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: long covid; children; SARS-CoV-2

Online: 9 March 2021 (12:37:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0148.v1

Ultrasound-Guided Nerve Hydrodissection for Pain Management: An Updated Review of Anatomy and Techniques

King Hei Stanley Lam, Chen-Yu Hung, Yi-Pin Chiang, Kentaro Onishi, Thomas B. Clark, Dean K Reeves, Su Daniel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: nerve hydrodissection; pain management; ultrasonography; neuropathic pain

Online: 15 January 2020 (12:09:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0239.v1

Synthesis and Characterization of Dibutyltin Compounds with α-Amino Acids

Roberto Santos Barbiéri, Vilma Reis Terra, Allan Kardec Carlos Dias, Walclée De Carvalho Melo, Daniel Rodrigues Silva

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: organotin compounds; dibutyltin compounds; tin α-amino acids compounds; thermal decomposition

Online: 31 August 2016 (10:43:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0115.v1

Electrical Heating for Heavy Oil: Past, Current, and Future Prospect

Muhammad Yudatama Hasibuan, Shania Regina, Rizaldi Wahyu, Daniel Situmorang, Fadlul Azmi, Rinaldi Syahputra, Laila Putri Yanti Batubara, Fauzi Prabowo, Ade Setiawan, Muhammad Fadhil Afin, Muhammad Khoirul Afdhol, Tomi Erfando

Subject: Engineering, Energy And Fuel Technology Keywords: electrical heating; heavy oil; visocsity; energy efficiency

Online: 12 January 2020 (13:25:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0391.v1

Effect of Energy Balance Evaluation on Conceptual Design of Electric and Hybrid Aircraft

Jozsef Rohacs, Daniel Rohacs

Subject: Engineering, Mechanical Engineering Keywords: full electric aircraft; hybrid aircraft; energy and mass balance equations; conceptual design; constraints

Online: 22 August 2018 (05:13:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0364.v1

Seed Priming Technology as a Key Strategy to Increase Crop Plant Production under Adverse Environmental Conditions

Daniel Garcia, Samiah Arif, Yinglei Zhao, Shuo Zhao, Lin Chau Ming, Danfeng Huang

Subject: Biology And Life Sciences, Horticulture Keywords: stress tolerance; biological mechanisms; biotic/Abiotic stress; hybrid priming; high-quality seeds

Online: 21 September 2021 (14:02:07 CEST)

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Preprint ARTICLE | doi:10.3390/sci1020045

Influence of Gravitational Shielding on Time Dilation

Stanley Raj, Sohan Jheeta, Daniel, Arun Krishna, Joseph Pious, Hudson Oliver

Subject: Physical Sciences, Theoretical Physics Keywords: gravitational shielding; Casimir effect; electromagnetic field; gravity

Online: 8 August 2019 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0061.v1

Generalized Triangular Intuitionistic Fuzzy Geometric Averaging Operator for Decision Making in Engineering

Daniel O. Aikhuele, Sarah Odofin

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: generalized triangular intuitionistic fuzzy geometric aggregation operator; triangular intuitionistic fuzzy number; intuitionistic fuzzy set; multi-criteria decision-making; attitudinal character; flexibility

Online: 14 June 2017 (05:55:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0059.v1

Assessing the Impacts of Urbinization on the Climate of Kumasi

Caleb Mensah, Julia Atayi, Amos T. Kabo-bah, Marian Švik, Daniel Acheampong

Subject: Physical Sciences, Biophysics Keywords: landuse change; climate change; garden city model; green vegetation; Landsat; urban heat island

Online: 4 September 2018 (06:28:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0025.v1

Broad Band Observations Of Gravitationally Lensed Blazar QSO B0218+357 During A Gamma-Ray Outburst

Julian Sitarek, Josefa Becerra González, Sara Buson, Dijana Dominis Prester, Marina Manganaro, Daniel Mazin, Kari Nilsson, Mireia Nievas, Antonio Stamerra, Fabrizio Tavecchio, Ievgen Vovk

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Gamma rays: galaxies; Gravitational lensing: strong; Galaxies: jets; Radiation mechanisms: non-thermal; Galaxies: individual: QSO B0218+357

Online: 13 July 2016 (05:36:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0268.v1

Candles from Soybean Seed Oil Extract

Modupe Ojewumi, Basil Ruth, Oyekunle Daniel

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Soybeans, Soxhlet extraction, Oil extract, solvent, Yield

Online: 26 August 2019 (13:54:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0048.v1

A Review of Power Compensation Techniques: Challenges and Recommendations for Future Investigation

Daniel Esene Okojie, Phinias Kgori, Udochukwu Bola Akuru

Subject: Engineering, Electrical And Electronic Engineering Keywords: electrical systems; power compensation techniques; multistage capacitor banks; power quality; power system safety; mines electrical power supply

Online: 2 November 2022 (06:22:34 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202103.0194.v1

scikit-activeml: A Library and Toolbox for Active Learning Algorithms

Daniel Kottke, Marek Herde, Tuan Pham Minh, Alexander Benz, Pascal Mergard, Atal Roghman, Christoph Sandrock, Bernhard Sick

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Active Learning, Classification, Machine Learning, Python, Github, Repository, Open Source

Online: 5 March 2021 (21:14:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0032.v1

Impact of Volcanic Ash on Road and Airfield Surface Skid Resistance

Daniel M. Blake, Thomas M. Wilson, Jim W. Cole, Natalia I. Deligne, Jan M. Lindsay

Subject: Environmental And Earth Sciences, Environmental Science Keywords: asphalt; concrete; runway; highway; traction; British Pendulum Tester; safety

Online: 14 July 2017 (10:11:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0413.v1

A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) Extendible to Citrus Genus

José Daniel Padilla de la Rosa, Priscilla Ruiz-Palomino, Guadalupe M. Guatemala-Morales, Jorge A. García-Fajardo, Georgina C. Sandoval-Fabián, Enrique Arriola-Guevara

Subject: Engineering, Chemical Engineering Keywords: Citrus aurantifolia Swingle; hesperidin; citrus byproducts; adsorption

Online: 19 November 2018 (04:14:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0361.v1

Socio-Economic Factors Influencing Use and Adoption of Family-Sized Bio-digesters as Renewable Energy Sources in Ngoma District, Rwanda

Danson Musinguzi, Emmanuel Kayinamura, Anne Tumushabe, Daniel Omuna, Emmaniel Innocent Eniru, Oluwole Olusegun Akiyode, Hadijjah Katongole, Edson Mwebesa, Twaha Ali Basamba, Dominic Byarugaba

Subject: Engineering, Energy And Fuel Technology Keywords: bio-digesters; household income levels; renewable energy; socio-economic

Online: 25 May 2018 (10:55:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0097.v2

Natural Pathogen Inhibiting Chemistry to Replace Toxic Treatment of Microbes and Biofilm in Cooling Towers ^†

Lon Brouse, Richard Brouse, Daniel Brouse

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pathogens; Legionella; amoeba; protozoa; biofilm; antibacterial; antimicrobial; cooling towers; biocides; polyvalent metals

Online: 20 December 2016 (10:26:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0048.v2

Uridine Triphosphate Thio-analogues Inhibit Platelet P2Y₁₂ Receptors and Aggregation

Dursun Guenduez, Christian Tanislav, Daniel Sedding, Mariana Parahuleva, Sentot Santoso, Christian Troidl, Christian Hamm, Muhammad Aslam

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: 2S-UTP; 4S-UTP; P2Y12 receptors; ADP; platelet aggregation

Online: 28 December 2016 (10:46:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0013.v1

Interannual Variability and Seasonal Predictability of Wind and Solar Resources

Nir Y. Krakauer, Daniel S. Cohan

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: renewable energy; solar; wind; interannual variability; seasonal forecasting; teleconnections

Online: 7 July 2017 (03:55:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints201707.0045.v1

Fighting Cancer with Mathematics and Viruses

Daniel N. Santiago, Johannes P. W. Heidbuechel, Wendy M. Kandell, Rachel Walker, Christine E. Engeland, Daniel Abate-Daga, Heiko Enderling

Subject: Biology And Life Sciences, Virology Keywords: oncolytic virotherapy; combination therapy; mathematical model; immune system; cancer; immunotherapy

Online: 17 July 2017 (13:01:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0591.v1

Neuromuscular Adverse Events Associated with Anti-PD-1 Monoclonal Antibodies: Systematic Review

Annette Johansen, Søren Just Christensen, David Scheie, Joan L. S. Højgaard, Daniel Kondziella

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: adverse events; immune checkpoint inhibitor; myasthenia gravis; myopathy; neuropathy; nivolumab; pembrolizumab

Online: 29 September 2018 (11:28:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0065.v1

Solar PV Cost Reduction Potential in Japan

Robert Höller, Daniel Gudopp, Tobias Leschinsky

Subject: Engineering, Energy And Fuel Technology Keywords: Solar PV; cost reduction; balance of system; Japan

Online: 5 April 2019 (12:10:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201803.0005.v1

Chitosan Derivatives: Introducing New Functionalities with a Controlled Molecular Architecture for Innovative Materials ^†

Waldo M. Argüelles-Monal, Jaime Lizardi-Mendoza, Daniel Fernández-Quiroz, Maricarmen T. Recillas-Mota, Marcelino Montiel-Herrera

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: chitin; chitosan; derivatization; controlled functionalization, click chemistry; graft copolymer; cyclodextrin; dendrimer; ionic liquids

Online: 1 March 2018 (07:13:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0291.v1

Modelling Hypertension and Risk Factors among Adults Using Ordinal Logistics Regression Model

Monday Osagie Adenomon, Daniel Owoicholofu John

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Hypertension; Risk; Factor; Ordinal; Odd ratio; Logistic; regession

Online: 24 January 2020 (16:08:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0045.v1

Socioeconomic Indicators of Bamboo Use for Agroforestry Development in the Dry Semi-Deciduous Forest Zone of Ghana

Daniel S. Akoto, Manfred Denich, Samuel T. Partey, Frith Oliver, Michael Kwaku, Alex A. Mensah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: adoption; land-use; degradation; ethnobotany; networking; agroforestry; dry semi-deciduous

Online: 7 November 2017 (04:06:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0181.v1

Design of Acoustical Bessel-Like Beam Formation by Tunable Angular Spectrum in Soret Zone Plate Lens

Daniel Tarrazó-Serrano, Sergio Castiñeira-Ibáñez, Oleg V. Minin, Pilar Candelas, Constanza Rubio, Igor V. Minin

Subject: Physical Sciences, Acoustics Keywords: ultrasonic lens; apodization; Soret zone plate

Online: 11 September 2018 (04:40:19 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201802.0134.v1

Arbidol (Umifenovir): A Broad-spectrum Antiviral Drug that Inhibits Medically Important Arthropod-borne Flaviviruses

Jan Haviernik, Michal Stefanik, Martina Fojtikova, Sabrina Kali, Noël Tordo, Ivo Rudolf, Zdenek Hubalek, Ludek Eyer, Daniel Ruzek

Subject: Biology And Life Sciences, Virology Keywords: flavivirus; arbidol; umifenovir; antiviral activity; cytotoxicity; cell-type dependent antiviral effect

Online: 21 February 2018 (14:44:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0199.v1

Revealing SARS-CoV-2 Functional Druggability Through Multi-Target Cadd Screening of Repurposable Drugs

Yash Gupta, Dawid Maciorowski, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Ajay Bharti, Daniel Becker, Rathi Brijesh, Steven B Bradfute, Ravi Durvasula, Prakasha Kempaiah

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; CADD; virtual screening; approved drugs; drug repurposing; essential targets; molecular docking; molecular dynamics simulations

Online: 11 May 2020 (13:14:18 CEST)

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The emergence of SARS/MERS drug resistant COVID-19 with high transmission and mortality has recently been declared a deadly pandemic causing economic chaos and significant health problems. Like all coronaviruses, SARS-CoV-2 is a large virus that has many druggable components within its proteome. In this study, we focused on repurposing approved and investigational drugs by identifying potential drugs that are predicted to effectively inhibit critical enzymes within SARS-CoV-2. We shortlisted seven target proteins with enzymatic activities known to be essential at different stages of the virus life cycle. For virtual screening, the energy minimization of a crystal structure or modeled protein was carried out using Protein Preparation Wizard (Schrödinger LLC, 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs (n=5903) that are already approved by worldwide regulatory bodies including the FDA, using the ZINC database. Screening was performed against viral targets using three sequential docking modes (i.e. HTVS, SP and XP). Our in-silico virtual screening identified ~290 potential drugs based on the criteria of energy, docking parameters, ligand and binding site strain and score. Drugs specific to each target protein were further analyzed for binding free energy perturbation by molecular mechanics (prime MM-GBSA) and pruning the hits to the top 32 candidates. A top lead from each target group was further subjected to molecular dynamics simulation (MDS) using the Desmond module to validate the efficacy of the screening pipeline. All of the simulated hit-target complexes were predicted to strongly interact and with highly stable binding. Thus, we have identified a number of approved and investigational drugs with high likelihood of inhibiting a variety of key SARS-CoV-2 proteins. Follow-up studies will continue to identify inhibitors suitable for combination therapy based on drug-drug synergy to thwart resistance. In addition, the screening hits that we have identified provide excellent probes for understanding the binding properties of the active sites of all seven targets, further enabling us to derive consensus molecules through computer-aided drug design (CADD). While infections are expanding at a rampant pace, it must be recognized that resistance will grow commensurately through either genetic shift and/or genetic drift to all small molecule drugs identified. Vaccines should provide a more permanent solution through prevention, but resistivity is still a possible scenario. Nevertheless, a persistent multi-target drug development program is essential to curb this ongoing pandemic and to keep reemergence in check.

Preprint ARTICLE | doi:10.20944/preprints201711.0199.v2

Self-Sampling for HPV Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

Sarah Gupta, Christina Palmer, Elisabeth M. Bik, Juan P. Cardenas, Harold Nuñez, Laurens Kraal, Sara Bird, Jennie Bowers, Alison Smith, Nathaniel A. Walton, Audrey D. Goddard, Daniel E. Almonacid, Jessica Richman, Zachary S. Apte

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: human papillomavirus; HPV; cervical cancer; cancer screening; self-sampling; vaginal microbiome

Online: 1 December 2017 (07:19:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0492.v2

COVID-19 Pandemic in Nigeria: Misconception Among Individuals, Impact on Animals and the Role of Mathematical Epidemiologists

Oluwasegun Micheal Ibrahim, Damilola Daniel Ekundayo

Subject: Social Sciences, Psychology Keywords: COVID-19; pandemic; misconception; mathematical modeling; infectious disease; Nigeria

Online: 20 January 2021 (14:11:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0148.v1

Information Theoretic Source Seeking Strategies for Multiagent Plume Tracking in Turbulent Fields

Hadi Hajieghrary, Daniel C. Mox, M. Ani Hsieh

Subject: Engineering, Control And Systems Engineering Keywords: multi-agent systems; information theory; distributed control; value of information; collaborative search

Online: 29 November 2016 (07:20:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0199.v1

Improving Quantitative Rainfall Prediction Using Ensemble Analogues in the Tropics: Case study of Uganda

Isaac Mugume, Michel d. S. Mesquita, Yazidhi Bamutaze, Didier Ntwali, Charles Basalirwa, Daniel Waiswa, Joachim Reuder, Revocatus Twinomuhangi, Fredrick Tumwine, Triphonia Jakob Ngailo, Bob Alex Ogwang

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Ensemble mean; Analogue ensemble mean; Multi–member analogue ensemble mean; Quantitative rainfall prediction

Online: 31 October 2017 (16:28:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0050.v1

On a Long Term Strategy for the Success of Nuclear Power

Bruno Merk, Dzianis Litskevich, Karl R. Whittle, Mark Bankhead, Richard Taylor, Daniel Mathers

Subject: Engineering, Energy And Fuel Technology Keywords: nuclear; reactor; spent fuel; P&T; innovation strategy; molten salt reactor

Online: 10 April 2017 (06:20:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints201803.0130.v1

Organochlorine Pesticides in Honey and Pollen Samples from Managed Colonies of the Honey Bee Apis mellifera Linnaeus and the Stingless Bee Scaptotrigona mexicana Guérin from Southern, Mexico

Jovani Ruiz-Toledo, Rémy Vandame, Ricardo A. Castro-Chan, Rosa P. Penilla-Navarro, Jaime Gómez, Daniel Sánchez

Subject: Biology And Life Sciences, Insect Science Keywords: pesticides; native bee; persistency; biomonitoring

Online: 16 March 2018 (06:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0698.v1

RoadLytics: Road Accidents Analytics Using Artificial Intelligence to Support Deaths’ Prevention on Highways

Kelvin Luz, João Elison da Rosa Tavares, Jorge Luis Victória Barbosa, Daniel Hernández de la Iglesia, Valderi Reis Quietinho Leithardt

Subject: Computer Science And Mathematics, Information Systems Keywords: Accidents, Data Analysis, Machine Learning, Transport

Online: 28 May 2021 (11:59:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0153.v1

A Hitchhiker’s Guide to Working with Large, Open-Source Neuroimaging Datasets

Corey Horien, Stephanie Noble, Abigail Greene, Kangjoo Lee, Daniel Barron, Siyuan Gao, Dave O'Connor, Mehraveh Salehi, Javid Dadashkarimi, Xilin Shen, Evelyn Lake, R. Todd Constable, Dustin Scheinost

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Open-science; big data; fMRI; data sharing; data management

Online: 8 July 2020 (11:53:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0500.v1

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Mohammad Mukarram, Sadaf Choudhary, Mo Ahamad Khan, Palmiro Poltronieri, M. Masroor A. Khan, Jamin Ali, Daniel Kurjak, Mohd Shahid

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: anticancer; antimicrobial; antioxidants; cancer signalling; citral; Cymbopogon; essential oil

Online: 21 June 2021 (10:31:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0024.v1

Sub-Chronic Toxicity Study of Hydroethanolic Leaf Extract of Telfairia Occidentalis Hook. F. (Cucurbitaceae) in Rats

Abidemi J. Akindele, Joy A. Oladimeji-Salami, Ramon A. Oyetola, Daniel D. Osiagwu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Telfairia occidentalis; Cucurbitaceae; subchronic; toxicity; biochemical; haematological

Online: 7 August 2017 (16:00:43 CEST)

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Background: The leaf of Telfairia occidentalis Hook f. (Cucurbitaceae) is consumed in different parts of Nigeria because of the numerous nutritional and medicinal attributes ascribed to it. The sub-chronic toxicity of the hydroethanolic leaf extract of Telfairia occidentalis (TO) was investigated in this study. Methods: Rats in different groups were separately administered 80, 400 and 2000 mg/kg TO p.o. for 60 days. Animals were sacrificed and blood samples collected for haematological and biochemical analysis. Vital organs were harvested and evaluated for in vivo antioxidants and histopathological changes. Results: Results showed no significant changes in the weight of vital organs except in respect of the testes of the group treated with 2000 mg/kg extract which showed a significant (p<0.05) reduction in weight compared to the control group. There was a significant (p<0.01) increase in sperm motility and count of the group administered 80 mg/kg extract and a significant (p<0.001) reduction was observed at 2000 mg/kg. There were significant increases in the level of Hb and PCV at 80 and 2000 mg/kg of the extract. In respect of liver function parameters, a significant decrease in AST and ALT levels at doses of 400 and 2000 mg/kg relative to control was observed. A significant reduction (p<0.05) in the level of total cholesterol (400 mg/kg) and increase (p<0.05) in level of HDL (80-2000 mg/kg) compared to control was observed. There was also significant (p<0.05) increase in the level of MDA and significant (p<0.05) decrease in SOD level in the testes at 2000 mg/kg. Histopathological assessment of the testes revealed abnormality at this dose. These effects were reversed after 30 days of cessation of administration of TO. Conclusions: The findings showed that the hydroethanolic leaf extract of Telfairia occidentalis is relatively non-toxic on acute and sub-chronic exposure, with potential to elicit anti-anaemic effect, reduce the risk of atherosclerosis and cardiovascular disease, and enhance antioxidant status in the brain and liver. Although possibly beneficial at low dose, the extract could be harmful to the testes on prolonged oral exposure at high dose.

Preprint ARTICLE | doi:10.20944/preprints202010.0132.v1

pandapipes: an Open Source Piping Grid Calculation Package for the Application in Coupled Multi-Energy Grid Simulations

Daniel Lohmeier, Dennis Cronbach, Simon Ruben Drauz, Martin Braun, Tanja Manuela Kneiske

Subject: Engineering, Energy And Fuel Technology Keywords: sector coupling; gas grid; district heating grid; grid simulation; network analysis; grid operation; open source; multi-energy grids; energy supply; infrastructure design

Online: 6 October 2020 (14:48:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0632.v1

Antimicrobial Use, Residues, Resistance and Governance in the Food and Agriculture Sectors, Tanzania

Robinson H. Mdegela, Elibariki R. Mwakapeje, Bachana Rubegwa, Daniel T. Gebeyehu, Solange Niyigena, Victoria Msambichaka, Hezron E. Nonga, Nicolas Antoine-Moussiaux, Folorunso O. Fasina

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antimicrobial use; antimicrobial residues; antimicrobial resistance; food and agriculture sectors; Tanzania

Online: 24 December 2020 (14:18:09 CET)

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All infections are potentially curable as long as the etiological agents are susceptible to antimicrobials. The increased rate at which antimicrobials are becoming ineffective is a global health risk of increasing concern that threatens withdrawal of beneficial antimicrobials for disease control. Increased demand for food of animal origin, in particular eggs, meat and milk has led to intensification and commercial production systems where excessive use and misuse of antimicrobials may prevail. Antimicrobials, handled and used by farmers and animal attendants with no formal education may predispose to incorrect dosages, misuse, incorrect applications and non-adherence to withdrawal periods. A multimethod approach (desk review, field study and interviews) was used. Relevant establishments were also visited. High levels of resistance to penicillin G, chloramphenicol, streptomycin and oxytetracycline have been reported especially for Actinobacter pyogenes, Staphylococcus hyicus, Staphylococcus intermedius and Staphylococcus aureus from dairy cattle with mastitis and in humans. Similar trends were found in poultry where eggs and meat are contaminated with Escherichia coli strains resistant to amoxicillin + clavulanate, sulphamethoxazole and neomycin. An increasing trend of emerging multidrug resistant E. coli, Klebsiella pneumoniae, Staphylococcus aureus, and Salmonella was also found in food animals. An in-crease in methicillin resistant Staphlococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) in the livestock sector in Tanzania have been reported. Specific antimicrobials resistant to were ampicillin, augmentin, gentamicin, cotrimoxazole, tetracycline, amoxicillin, ampicillin, gentamicin, streptomycin, erythromycin, tetracycline, ciprofloxacin, nalidixic acid, azithromycin, chloramphenicol, tylosin, erythromycin, cefuroxime, norfloxacin and ciprofloxacin. An in-creased usage of antimicrobials for prophylaxis, anaphylaxis and therapeutics against pathogens and for growth promotion in livestock, aquaculture and crops production were observed. One Health strategic approach is advocated to combat AMR in the food and agriculture sectors in Tanzania. Practical recommendations include a) legislation review and implementation, b) AMU, AMR and AR awareness and advocacy among stakeholders along the value chain, c) strengthening of surveillance and monitoring programs for AMU, AMR and AR, d) enhance development and use of rapid and innovative diagnostic tests and promotion biosecurity principles and e) good husbandry practices. The utilization of this information to improve public health policies and reduce the burden of AMR will be beneficial.

Preprint ARTICLE | doi:10.20944/preprints202102.0514.v1

AlphaLogD Determination: A New Generation Reversed-Phase HPLC Method to Measure Lipophilicity on Neutral and Basic Small and Beyond-Rule-of-Five Compounds

Daniel Katz, Kate Fike, Justin Longenberger, Steve Placko, Laurence Philippe-Venec, Andrew Chervenak

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: High Performance Liquid Chromatography; Superficially Porous Particle; Shake-Flask method; Lipophilicity; Beyond-Rule-of-5

Online: 23 February 2021 (14:07:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0079.v1

Cryptic Species Diversity of Rice Hopper Parasitoids in Southeast Asia

Christina Sann, Franziska Wemheuer, Alexis Beaurepaire, Rolf Daniel, silvio Erler, Stefan Vidal

Subject: Biology And Life Sciences, Insect Science Keywords: DNA barcoding; genetic diversity; hymenopteran parasitoids; Nephotettix spp.; Nilaparvata lugens; rice

Online: 13 November 2017 (17:06:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0056.v1

Conditioning Factors in the Transition Process to the Self-Care of Women with AIDS

Claudia Regina de Andrade Arrais Rosa, Simony Fabíola Lopes Nunes, Regiane Silva de Jesus, Francisco Dimitre Rodrigo Pereira Santos, Leila Rute Oliveira Gurgel do Amaral, Nilviane Pires Silva Sousa, Daniel Costa Duarte, Allan Kardec Barros Duailibe Filho

Subject: Social Sciences, Psychology Keywords: nursing theory; self-care women; HIV

Online: 10 October 2017 (02:55:22 CEST)

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Working Paper ARTICLE

Modified Full-Face Snorkel Mask as COVID-19 Personal Protective Equipment: Quantitative Results

Kyle Nicholson, Ashley Henke-Adams, Daniel M. Henke, Alexxai V. Kravitz, Hiram A. Gay

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; mask; respirator; coronavirus; 3D Printing; N95; personal protective equipment (PPE)

Online: 11 July 2020 (04:16:17 CEST)

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Preprint OPINION | doi:10.3390/sci2030057

Global Significance of Mangrove Blue Carbon in Climate Change Mitigation (Version 1)

Daniel Alongi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: blue carbon; carbon; carbon stock; carbon sequestration; climate change; CO₂ emissions; mangrove; mitigation

Online: 23 July 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0171.v1

Specific and Complete Local Integration of Patterns in Bayesian Networks

Martin Biehl, Takashi Ikegami, Daniel Polani

Subject: Computer Science And Mathematics, Mathematics Keywords: identity over time; Bayesian networks; multi-information; entity; persistence; integration; emergence; naturalising agency

Online: 21 March 2017 (16:23:00 CET)

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Working Paper COMMUNICATION

Open Questions for Harnessing Autophagy-Modulating Drugs in the SARS-CoV-2 War: Hope or Hype?

Patrick Brest, Jonathan Benzaquen, Daniel J. Klionsky, Paul Hofman, Baharia Mograbi

Subject: Biology And Life Sciences, Virology Keywords: anti-viral; COVID-19; SARS-CoV-2; autophagy; chloroquine; hydroxychloroquine; immunology; infection; inflammation; lysophagy; microbiology; Plaquenil; SARS; virophagy

Online: 23 May 2020 (10:45:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0570.v1

Towards End-to-End Acoustic Localization Using Deep Learning: From Audio Signal to Source Position Coordinates

Juan Manuel Vera-Diaz, Daniel Pizarro, Javier Macias-Guarasa

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: acoustic source localization; microphone arrays; deep learning; convolutional neural networks

Online: 30 July 2018 (09:37:37 CEST)

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Working Paper REVIEW

The Retinal Basis of Vision in Chicken

Marvin Seifert, Tom Baden, Daniel Osorio

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Retina; Bird vision; Colour vision

Online: 11 March 2020 (16:00:46 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0196.v1

Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Daniel Missailidis, Sarah Annesley, Paul Fisher

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, ME/CFS, diagnosis, metabolism, mitochondria, inflammation, immune system, signaling, gut microbiota.

Online: 16 July 2019 (12:41:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0118.v1

Species Delimitation in Sea Anemones (Anthozoa: Actiniaria): From Traditional Taxonomy to Integrative Approaches

Carlos A. Spano, Cristian B. Canales-Aguirre, Selim S. Musleh, Vreni Häussermann, Daniel Gomez-Uchida

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Cnidaria; Hexacorallia; systematics; taxonomy; evolution

Online: 10 November 2019 (16:39:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0140.v1

Influence of Alkali Metal Substitution on the Phase Transition Behavior of CsGaQ2 (Q = S, Se)

Daniel Friedrich, Marc Schlosser, Martin Etter, Arno Pfitzner

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: chalcogenogallates; polymorphism; solid solutions; in situ X-ray diffraction; synchrotron radiation; rietveld refinement

Online: 20 October 2017 (12:53:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0402.v1

From m⁶A to Cap-Adjacent m⁶Am and Their Effects on mRNAs

Trinh Tat, Daniel Kiss

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Epitranscriptome; PCIF1; N6; 2’-O-dimethyladenosine; cap-adjacent m6Am; cytoplasmic capping

Online: 16 November 2020 (08:56:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0101.v1

The Utility of Grimace Scales for Practical Pain Assessment in Laboratory Animals

Daniel Mota-Rojas, Adriana Olmos-Hernández, Antonio Verduzco-Mendozab, Elein Hernández, Julio Martínez-Burnes, Alexandra Whittaker

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: facial expressions; pain; grimace scales; mice; rat; rabbit

Online: 4 September 2020 (11:18:42 CEST)

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Working Paper COMMUNICATION

Compelling Alternative Theories for Exclusion Zone Phenomena in Water and Other Liquids

Daniel Elton

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: water; exclusion zone; diffusiophoresis; repulsive van der Waals

Online: 19 September 2019 (03:51:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0042.v1

Organic Food Products Labeling Innovation: The Case for Sustainable Food Consumption Behavior

Daniel Adrian Gârdan, Ionel Dumitru, Ilić Dragan, Iuliana Petronela Gârdan, Mihai Andronie, Cristian Uță

Subject: Business, Economics And Management, Marketing Keywords: products labeling; organic food products labeling; labeling innovation; sustainable food consumption; buying decision

Online: 2 May 2018 (13:10:20 CEST)

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Working Paper ARTICLE

Operationalising Forensic Genetic Genealogy in an Australian Context

Nathan Scudder, Runa Daniel, Jennifer Raymond, Alison Sears

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: forensic genetic genealogy; investigative genetic genealogy; DNA; forensic DNA

Online: 1 August 2020 (16:29:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0385.v1

Development of a Stoichiometric Model for Estimation of Metabolic Fluxes in Saccharomyces cerevisiae during Tequila Production

José Daniel Padilla-de la Rosa, Anne Gschaedler-Mathis, Abril Gomez-Guzman, Orfil González-Reynoso

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: flux balance analysis; Saccharomyces cerevisiae; tequila; fermentation; higher alcohols

Online: 16 November 2018 (07:37:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0323.v1

Synthesis and Characterization of Slow-Release Fertilizer Hydrogels Based on Hydroxy Propyl Methyl Cellulose, Polyvinyl Alcohol, Glycerol and Blended Paper as Second Layer

Fartisincha Peingurta Andrew, Daniel T Gungula, Semiu A Kareem, Abdullahi M Saddiq, Esther F Adebayo, Idayatu Dare, Vadlya T Tame, Kefas Mavakumba Haruna, Patrick D Onoja, Japari Joseph

Subject: Chemistry And Materials Science, Paper, Wood And Textiles Keywords: Hydrogel; Blended paper; Slow-release fertilizer; Hydroxy Propyl Methyl Cellulose; polyvinyl alcohol

Online: 22 October 2021 (09:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0552.v1

Role of Information Technology in COVID19 Vaccination Drive: An Analysis of the COVID-19 Global Beliefs, Behaviors, and Norms Survey

Debjyoti Talukdar, Kire Stojkovski, Daniel Suarez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID19; vaccine; SARS nCoV-2; information technology; COVID19 vaccine survey; MIT vaccine survey

Online: 20 April 2021 (14:35:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0267.v2

Systematic Review of Wastewater Surveillance of Antimicrobial Resistance in Human Populations

Kevin Chau, Leanne Barker, Eric Budgell, Karina-doris Vihta, Natalie Sims, Barbara Kasprzyk-Hordern, Elinor Harriss, Derrick Crook, Daniel Read, Sarah Walker, Nicole Stoesser

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: AMR; sewage; epidemiology; wastewater; surveillance

Online: 21 June 2021 (11:25:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0452.v1

Virtual Reality Tremor Reduction in Parkinson's Disease

John Cornacchioli, Alec Galambos, Stamatina Rentouli, Robert Canciello, Roberta Marongiu, Daniel Cabrera, eMalick G. Njie

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurodegeneration; Parkinson's disease; essential tremor; Deep Brain stimulation; Levodopa; Virtual Reality; Oculus Rift; Medical Virtual Reality; Tremor stabilization; Equalizers

Online: 29 February 2020 (03:56:19 CET)

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Preprint REVIEW | doi:10.20944/preprints201802.0084.v1

Dual Antiplatelet Therapy (DAPT) in Coronary Artery Disease: A Daunting Dilemma

Suryateja Chaturvedula, Daniel J. Diver, Aseem Vashist

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: dual anti platelet therapy; acute coronary syndrome; stents

Online: 12 February 2018 (05:13:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0533.v1

Virulence Effectors of Pathogenic Mycoplasmas

Meghan A. May, Daniel R. Brown

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: mycoplasma; virulence effectors; pathogenesis

Online: 27 September 2018 (05:54:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0271.v1

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Daniel Ziental, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Arleta Glowacka-Sobotta, Beata Stanisz, Tomasz Goslinski, Lukasz Sobotta

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: composites; nanoparticles; photodynamic therapy; photosensitizer; titanium dioxide

Online: 19 February 2020 (10:44:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0054.v1

Critical Issues in Modelling Lymph Node Physiology

Dmitry Grebennikov, Raoul van Loon, Mario Novkovic, Lucas Onder, Rostislav Savinkov, Igor Sazonov, Rufina Tretyakova, Daniel J. Watson, Gennady Bocharov

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: computational model; lymph node; multiscale structure; vascular network; fibroblastic reticular cells; conduit network; lymph flow; destruction of conduits

Online: 9 December 2016 (10:19:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0289.v1

Flat Slabs in Eccentric Punching Shear: Experimental Database and Code Analysis

Daniel Vargas, Eva O.L. Lantsoght, Aikaterini Genikomsou

Subject: Engineering, Civil Engineering Keywords: database; eccentric punching shear; experiments; flat slab; punching; reinforced concrete; shear

Online: 21 June 2022 (05:42:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0714.v1

Towards a Biomanufactory on Mars

Aaron Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew McNulty, George Makrygiorgos, Nils J.H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Desiree Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Meraz, Vince Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert W. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Amor A. Menezes, Lance C. Seefeldt, Douglas S. Clark, Adam P. Arkin

Subject: Engineering, Automotive Engineering Keywords: space systems bioengineering; human exploration; mars; in situ resource utilization; life support systems; biomanufacturing

Online: 29 December 2020 (07:57:37 CET)

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Preprint REVIEW | doi:10.20944/preprints201912.0253.v1

Intermediate Filaments as Potential Target for Cancer 2 Treatment

Katerina Strouhalova, Magdalena Přechová, Aneta Gandalovičová, Jan Brábek, Martin Gregor, Daniel Rosel

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: vimentin; EMT; invasion; mechanotransduction; cell adhesion; cancer treatment; cancer drugs; amoeboid; mesenchymal

Online: 19 December 2019 (07:58:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0132.v1

Conceal Carry and Race: A Test of Minority Threat Theory in Law Generation

Christopher W. Mullins, Daniel R. Kavish

Subject: Social Sciences, Sociology Keywords: minority threat; conceal carry laws; Missouri; race and ethnicity

Online: 27 September 2017 (02:03:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0098.v1

Assembly of the Boechera retrofracta Genome and Evolutionary Analysis of Apomixis-Associated Genes

Sergei Kliver, Mike Rayko, Alexey Komissarov, Evgeny Bakin, Daria Zhernakova, Kasavajhala V. S. K. Prasad, Catherine Rushworth, R. Baskar, Dmitry Smetanin, Jeremy Schmutz, Daniel S. Rokhsar, Thomas Mitchell-Olds, Ueli Grossniklaus, Vladimir Brukhin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Boechera; Brassicaceae; genome; assembly; annotation; apomixis

Online: 14 February 2018 (07:29:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0213.v1

Co-, Cu- and Fe-Doped Ni/Al₂O₃ Catalysts for the Catalytic Decomposition of Methane into Hydrogen and Carbon Nanofibers

Daniel Torres, José Luis Pinilla, Isabel Suelves

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Ni catalysts; bimetallic catalysts; hydrogen; catalytic decomposition of methane; thermogravimetric analysis; carbon nanofibers

Online: 12 July 2018 (08:07:03 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201801.0220.v1

Maristem - Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications

Loriano Ballarin, Baruch Rinkevich, Kerstin Bartscherer, Artur Burzynski, Sebastien Cambier, Matteo Cammarata, Isabelle Domart-Coulon, Damjana Drobne, Juanma Encinas, Uri Frank, Anne-Marie Geneviere, Bert Hobmayer, Helike Löhelaid, Daniel Lyons, Pedro Martinez, Paola Oliveri, Lorena Peric, Stefano Piraino, Andreja Ramšak, Sebastian Rakers, Fabian Rentzsch, Amalia Rosner, Tiago Henriques da Silva, Ildiko Somorjai, Sherif Suleiman, Ana Varela Coelho

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: aging; bioactive molecules; blue biotechnology; cancer; cell culture; COST Action; Europe; marine/aquatic invertebrates; regeneration; stem cells

Online: 24 January 2018 (04:14:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0096.v1

Multifractal Comparison of Reflectivity and Polarimetric Rainfall Data from C- and X-Band Radars and Respective Hydrological Responses of a Complex Catchment Model

Igor Paz, Bernard Willinger, Auguste Gires, Laurent Monier, Christophe Zobrist, Bruno Tisserand, Ioulia Tchiguirinskaia, Daniel Schertzer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: complex catchment; weather X-band radars; flash floods; multifractals; spatio-temporal variability

Online: 14 October 2017 (03:10:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0612.v1

Daylight Performance of a Translucent Textile Membrane Roof with Thermal Insulation

Daniel Gürlich, Amando Reber, Andreas Biesinger, Ursula Eicker

Subject: Engineering, Civil Engineering Keywords: translucent textile membrane roof, climate-based daylight modelling, daylight performance, energy conservation, translucent thermal insulation, multi-layer membrane

Online: 31 July 2018 (08:58:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1300.v1

Is There a Risk for Semaglutide Misuse? Focus on the Food and Drug Administration-FDA Adverse Events Reporting System (FAERS) Pharmacovigilance Dataset

Stefania Chiappini, Rachel Vickers-Smith, Daniel Harris, Duccio G. Petellier Papanti, John M. Corkery, Amira Guirguis, Giovanni Martinotti, Stefano L. Sensi, Fabrizio Schifano

Subject: Biology And Life Sciences, Toxicology Keywords: semaglutide; drug misuse; drug abuse; pharmacovigilance; image- and performance-enhancing (IPED) drugs; glucagon-like peptide-1 (GLP-1) agonists

Online: 20 September 2023 (05:05:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0489.v1

Neurotherapeutics for Attention Deficit Hyperactivity Disorder (ADHD): a Review

Katya Rubia, Samuel Westwood, Pascal-M. Aggensteiner, Daniel Brandeis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Attention Deficit Hyperactivity Disorder (ADHD); functional magnetic resonance imaging (fMRI); Neurofeedback; EEG-Neurofeedback; fMRI-Neurofeedback; brain stimulation; transcranial magnetic stimulation (TMS); transcranial direct current stimulation (tDCS); trigeminal nerve stimulation (TNS).

Online: 18 June 2021 (15:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0249.v1

Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces

Rubén Tejero, Beatriz Gutiérrez, Daniel López, Fátima López-Fabal, José L. Gómez-Garcés, Alexandra Muñoz-Bonilla, Marta Fernández-García

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: cationic polymers; blends; surfaces; antimicrobial

Online: 26 January 2018 (05:31:49 CET)

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Working Paper COMMUNICATION

Sars-Cov-2 Wastewater Surveillance for Public Health Action: Connecting Perspectives From Wastewater Researchers and Public Health Officials During a Global Pandemic

Jill McClary-Gutierrez, Mia Mattioli, Perrine Marcenac, Andrea Silverman, Alexandria Boehm, Kyle Bibby, Michael Balliet, Francis de los Reyes III, Daniel Gerrity, John Griffith, Patricia Holden, Dimitrios Katehis, Greg Kester, Nathan LaCross, Erin Lipp, Jonathan Meiman, Rachel Noble, Dominique Brossard, Sandra McLellan

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: SARS-CoV-2; wastewater surveillance

Online: 7 June 2021 (13:01:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0436.v1

Partial Methane Oxidation in Fuel Cell-Type Reactors for Co-Generation of Energy and Chemicals

Rodrigo F. B. de Souza, Daniel Z. De Florio, Ermete Antolini, Almir O. Neto

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Methane Oxidation; reactor; generation energy; chemical

Online: 28 January 2022 (12:17:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0054.v1

Phosphate Detection in Hydroponics using Molecularly Imprinted Polymer Sensors

Christopher S. Storer, Zachary Coldrick, Daniel Tate, Jack Marsden Donoghue, Bruce Grieve

Subject: Engineering, Electrical And Electronic Engineering Keywords: hydroponics; interdigitated electrodes; molecularly imprinted polymer; nutrient monitoring; phosphate; polymer sensor; precision agriculture

Online: 8 January 2018 (09:22:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0057.v1

Fault-Tolerant Control for ROVs Using Control Reallocation and Power Isolation

Romano Capocci, Edin Omerdic, Gerard Dooly, Daniel Toal

Subject: Engineering, Marine Engineering Keywords: fault-tolerant control; thruster fault; fault detection and isolation; fault accommodation; ROV; remotely operated vehicle; underwater vehicle

Online: 8 March 2018 (02:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0138.v2

A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy

Wesley A. Williams, Ashley J. Denslow, Peter W. Radulovic, Daniel J. Denmark, Shyam S. Mohapatra

Subject: Chemistry And Materials Science, Nanotechnology Keywords: inorganic nanoparticles; in silico; optimization; theranostic; therapeutic; diagnostic; computation; coding; Python

Online: 7 September 2021 (11:57:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0478.v1

Risk Assessment of SARS-CoV-2 in Antarctic Wildlife

Andrés Barbosa, Arvind Vansani, Virginia Morandini, Wray Grimaldi, Ralph E.T. Vanstreels, Julia I. Diaz, Thierry Boulinier, Meagan Dewar, Daniel Gonzalez-Acuña, Rachel Gray, Clive R. McMahon, Gary Miller, Michelle Power, Amandine Gamble, Michelle Wille

Subject: Biology And Life Sciences, Virology Keywords: Antarctica; coronavirus; COVID-19; mitigation measures; reverse zoonoses; risk assessment; SARS-CoV-2; wildlife

Online: 21 August 2020 (09:21:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0012.v1

Integrated BIM-Based LCA for the Entire Building Process Using an Existing Structure for Cost Estimation

Anita Naneva, Marcella Bonanomi, Alexander Hollberg, Guillaume Habert, Daniel Hall

Subject: Engineering, Architecture, Building And Construction Keywords: Building Information Modelling (BIM); Life-Cycle Assessment (LCA); Building process; Level of Development (LOD); Embodied environmental impacts; Greenhouse Gas emissions (GHG); LCA databases; LCA values; LCA benchmarks; cost estimation structure

Online: 1 March 2020 (13:16:52 CET)

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Working Paper REVIEW

Framed Experiments and Games in Agriculture: A Systematic Review of the 21st Century in Economics and Social Science

J. Nicolas Hernandez-Aguilera, Max Mauerman, Alexandra Herrera, Kathryn Vasilaky, Walter Baethgen, Ana Maria Loboguerrero, Rahel Diro, Yohana Tesfamariam Tekeste, Daniel Osgood

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: review; games; field experiments; agriculture

Online: 12 August 2020 (14:47:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0070.v1

Brief Review of the Effects of Pressure on Wolframite-Type Oxides

Daniel Errandonea, Javier Ruiz-Fuertes

Subject: Physical Sciences, Condensed Matter Physics Keywords: wolframite, high-pressure, phase transitions, crystal structure, phonons, band structure.

Online: 8 January 2018 (18:22:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0104.v1

Cycle-consistent Generative Adversarial Networks (CycleGANs) for the Non-Parallel Creation of Fake Voice Media

Daniel Fleury, Angelica Fleury

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Deep Learning, Generative Adversarial Networks (GANs), Machine Learning, Autoencoders, Voice Conversion, Ethics, CycleGANs

Online: 12 June 2019 (11:17:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0092.v1

Machine Learning-based Anomaly Detection with Magnetic Data

Peetak Mitra, Denis Akhiyarov, Mauricio Araya-Polo, Daniel Byrd

Subject: Engineering, Mechanical Engineering Keywords: anomaly detection; machine Learning; large stand off magnetometry; multimodal data; RAPIDS-AI

Online: 4 December 2020 (07:13:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0694.v1

Energy Consumption and Usage Reduction in Lecture Halls, Kwame Nkrumah University of Science and Technology

Pius Nimoh, Daniel Duah, Alexander Marful

Subject: Social Sciences, Psychology Keywords: Electric energy; Occupant behavior; energy efficiency; lecture halls

Online: 29 June 2021 (08:44:05 CEST)

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