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Preprint ARTICLE | doi:10.20944/preprints202201.0357.v1

Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid

Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus Zabetian, Elaine R. Peskind, Ge Li, Daniel Promislow, Marie Y. Davis, Alexander Franks

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: predictive modeling; biomarker; cerebrospinal fluid; cross-sectional study; neurodegenerative disease

Online: 24 January 2022 (12:59:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0307.v1

Effect of Docosahexaenoic Acid as a Chemopreventive Agent on Experimentally Induced Hamster Buccal Pouch Carcinogenesis

Emad Alqalshy, Amr Mohamed Ibrahim, Ahmed Abdel-Shakour Abdel-Hafiz, Kamal Abd AbdEl-Rahman, Magdy Alazzazi, Mohamed Omar, Amr Saad Abdel-Wahab

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Docosahexaenoic acid; Chemoprevention; Bcl-2 family; Experimental Study; Hamster Buccal Pouch Carcinogenesis.

Online: 20 January 2022 (13:41:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0229.v1

Applying the FAIR4Health Solution to Identify Multimorbidity Patterns and Their Association With Mortality Through a Frequent Pattern Growth Association Algorithm

Jonás Carmona-Pírez, Beatriz Poblador-Plou, Antonio Poncel-Falcó, Jessica Rochat, Celia Alvarez-Romero, Alicia Martínez-García, Carmen Angioletti, Marta Almada, Mert Gencturk, Anil Sinaci, Jara Eloisa Ternero-Vega, Christophe Gaudet-Blavignac, Christian Lovis, Rosa Liperoti, Elisio Costa, Carlos Luis Parra-Calderón, Aida Moreno-Juste, Antonio Gimeno-Miguel, Alexandra Prados-Torres

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: FAIR principles; Multimorbidity; Mortality; Research data management; Pathfinder case study; Privacy-Preserving Distributed Data Mining.

Online: 17 January 2022 (13:04:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0078.v1

The Diabetes Transition of Hospital Care (DiaTOHC) Pilot Study: A Randomized Controlled Trial of an Intervention Designed to Reduce Readmission Risk of Adults with Diabetes

Daniel J Rubin, Preethi Gogineni, Andrew Deak, Cherie L Vaz, Samantha Watts, Dominic Recco, Felicia R Dillard, Jingwei Wu, Abhijana Karunakaran, Neil Kondamuri, Huaqing Zhao, Mary D Naylor, Sherita H. Golden, Shaneisha Allen

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: rehospitalization; transition care; pilot study; prospective randomized trial

Online: 6 January 2022 (11:40:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0132.v2

Relative Effectiveness of Cell-Cultured versus Egg-Based Seasonal Influenza Vaccines in Preventing Influenza-Related Outcomes in Subjects 18 Years Old or Older: A Systematic Review and Meta-Analysis

Joan Puig-Barberà, Sonia Tamames-Gómez, Pedro Plans-Rubio, José María Eirós-Bouza

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: adults; influenza; cell-cultured vaccine; egg-based vaccine; influenza vaccine; relative vaccine effectiveness; real word evidence; mutation; human / prevention &; control*; comparative study

Online: 20 December 2021 (11:00:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0016.v1

Perceptions of School Management on the Relationship between School Nutrition and Development of Non-communicable Diseases in a Rural South African District: A Qualitative Study

Sibusiso C. Nomatshila, Teke R. Apalata, Sikhumbuzo A. Mabunda

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Nutrition program; vendor system; qualitative study; obesity; non-communicable diseases

Online: 1 December 2021 (13:10:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0478.v1

You + ME Registry: A Research Platform to Facilitate Clinical and Therapeutic Discoveries in ME/CFS and Related Diseases

Allison Ramiller, Kathleen Mudie, Elle Seibert, Sadie Whittaker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Long COVID; data acquisition source; post-infectious; longitudinal cohort study; patient-powered

Online: 25 November 2021 (13:51:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0430.v1

Two Compounds of 1-((4-Bromothiophen-2-Yl)Methylene)-2-(Perfluorophenyl)Hydrazine, and 1-((4-Bromo-5-Methylthiophen-2-Yl)Methylene)-2-(Perfluorophenyl)Hydrazine and They Crystal, Molecular and Electronic Properties

Július Sivý, Dušan Bortňák, Daniel Végh, Erik Rakovský

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Ab initio DFT/B3LYP/6-311G/Auto calculation; hydrazine; Hirshfeld surface; hydrogen interactions; single-crystal X-ray study

Online: 23 November 2021 (15:03:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0386.v1

Meta-Analysis of Transcriptome-Wide Association Studies Across 13 Brain Tissues Identified Novel Clusters of Genes Associated with Nicotine Addiction

Zhenyao Ye, Chen Mo, Hongjie Ke, Qi Yan, Chixiang Chen, Elliot L Hong, Peter Kochunov, Braxton D Mitchell, Shuo Chen, Tianzhou Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genome-wide association study; transcriptome-wide association study; meta-analysis; expression quantitative trait loci; nicotine addiction

Online: 22 November 2021 (11:46:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0299.v1

An Empirical Study of the Impact of Systems Thinking and Simulation on Sustainability Education

Caroline J Green, Owen Molloy, Jim Duggan

Subject: Social Sciences, Education Keywords: Education for Sustainable Development; Systems Thinking; System Dynamics; simulation; transfer of skills; effectiveness; randomised controlled trial; RCT; factorial study; ANOVA

Online: 17 November 2021 (10:47:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0080.v1

The application of Artificial Intelligence to Ophthalmology: A bibliometric study (2000-2021)

Han Wang, Xiaoshu Zhou, Wencai Du, Lina Huang

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Artificial Intelligence; Ophthalmology; Bibliometric Study; CiteSpace; Machine Learning; Deep Learning.

Online: 3 November 2021 (13:39:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0429.v1

The Perceived Risk of Being Infected With COVID-19 at Work, Communication, and Employee Health: A Longitudinal Application of the Job Demands-Resources Model

Alessandra Falco, Damiano Girardi, Alessandro De Carlo, Elvira Arcucci, Laura Dal Corso

Subject: Social Sciences, Psychology Keywords: COVID-19; perceived risk; communication; psychophysical strain; longitudinal study.

Online: 28 October 2021 (09:58:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0160.v1

Clinical Experience with Anti-IgE Monoclonal Antibody (Omalizumab) In Paediatric Severe Allergic Asthma – A Romanian Perspective

Berghea Elena Camelia, Mihaela Balgradean, Carmen Pavelescu, Catalin Cirstoveanu, Claudia Toma, Marcela Daniela Ionescu, Roxana Silvia Bumbacea

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: allergic severe asthma; anti-IgE; Omalizumab; observational study; children

Online: 11 October 2021 (13:54:56 CEST)

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Working Paper ARTICLE

Percieved trust in Public Authorities Nine Months after the COVID-19 Outbreak: A Cross-National Study

Daicia Price, Tore Bonsaksen, Mary Ruffolo, Janni Leung, Vivian Chiu, Hilde Thygesen, Mariyana Schoultz, Amy Ostertun Geirdal

Subject: Business, Economics And Management, Accounting And Taxation Keywords: coronavirus; cross-national study; pandemic; public authorities; social media; trust

Online: 11 October 2021 (11:04:14 CEST)

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Working Paper ARTICLE

Genome-Wide Study Suggests an Association of the Enhancer rs10419198 for PRR12 Gene with Disordered Eating Behavior in the Mexican Population

José Jaime Martínez-Magaña, Sandra Hernandez, Ana Rosa Garcia, Valeria Cardoso-Barajas, Emmanuel Sarmiento, Beatriz Camarena, Alejandro Caballero, Laura Gonzalez, Jorge Ameth Villatoro-Velazquez, Maria Elena Medina-Mora, Marycarmen Bustos-Gamiño, Clara Fleiz-Bautista, Carlos Alfonso Tovilla-Zarate, Isela Esther Juárez-Rojop, Humberto Nicolini, Alma Delia Genis-Mendoza

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: feeding and eating disorder; genome-wide association study; methylation quantitative trait loci

Online: 8 October 2021 (14:23:39 CEST)

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Working Paper ARTICLE

Impact of Geopolitical Risk on the Information Technology, Communication Services & Consumer Staples Sectors of the S&P 500 Index

Gerard Atabong Fossung, Vasileios Chatzis Vovas, A.M.M. Quoreshi

Subject: Business, Economics And Management, Finance Keywords: Geopolitical risk; Event study; S&P 500 index; Information Technology; Communication Services; Consumer Staples

Online: 8 October 2021 (09:34:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0061.v1

Developing Computational Thinking to Help Tackle Pandemic Challenges

Roberto Araya, Masami Isoda, Johan van der Molen Morris

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: COVID-19; Computational Thinking; Computational Modeling; Lesson Study

Online: 4 October 2021 (14:37:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0423.v1

One-Year Prospective Study of Occupational Health in the Intensivists of a COVID-19 Hub Hospital

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: longitudinal study; emergency; infectious disease; organizational justice; stress; loneliness; compassion fatigue; meditation; prayer; insomnia; mental health; anaesthetists

Online: 23 August 2021 (10:22:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0283.v1

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Mohamed Jahromi, Mona Al Sheikh, Jaakko Tuomilehto

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Type 1 diabetes; human leukocyte antigen; Kuwait Type 1 Diabetes Study; Islet autoantibodies; Insulin; prediction

Online: 13 August 2021 (08:19:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0599.v2

Clinical Experience with the Fifth-Generation of a Breast Implant with a Smooth, Fine Surface from a Korean Manufacturer in Asian Women

Dong Yeon Hwang, Sang Wha Kim, Joon Yong Jung

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Clinical Study; Retrospective Studies; Surgical Procedures, Operative; Postoperative Period; Follow-Up Studies.

Online: 28 July 2021 (16:56:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0571.v1

An Analysis of Students’ Perception of University Sustainability Programs and Image

Samuel Adeyanju

Subject: Business, Economics And Management, Accounting And Taxation Keywords: university; HEI; students; sustainability; UBC; qualitative study; perception

Online: 26 July 2021 (11:48:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0489.v1

Students’ Perceptions of Doctoral Defense in relation to Socio-Demographic Characteristics

Eva O.L. Lantsoght

Subject: Social Sciences, Education Keywords: academia; affective dimension; defense formats; ethnicity; field of study; gender; socio-demographic dimensions; viva; viva voce

Online: 21 July 2021 (11:26:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0461.v1

Persistence of Multiple Paramyxoviruses in a Closed Captive Colony of Fruit Bats (Eidolon helvum)

Louise Gibson, Maria Puig Rebas, James Kemp, Olivier Restif, Richard D. Suu-Ire, James L.N. Wood, Andrew Alexander Cunningham

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chiroptera; Pteropodidae; longitudinal study; Henipavirus; Pararubulavirus

Online: 20 July 2021 (16:05:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0206.v1

Sensitivity of Ultrasonic Coda Wave Interferometry to Material Damage - Observations from a Virtual Concrete Lab

Claudia Finger, Leslie Saydak, Giao Vu, Jithender J. Timothy, Günther Meschke, Erik H. Saenger

Subject: Chemistry And Materials Science, Biomaterials Keywords: damage detection; concrete-like structures; coda waves; ultrasound; wave propagation; discrete element modeling; sensitivity study

Online: 8 July 2021 (15:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0125.v1

Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: National Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process

Blandine Courbiere, Enora Le Roux, Emmanuelle Mathieu d’Argent, Antoine Torre, Catherine Patrat, Christophe Poncelet, Jacques Montagut, Anne-Sophie Gremeau, Hélène Creux, Maëliss Peigné, Isabella Chanavaz-Lacheray, Lara Dirian, Xavier Fritel, Jean-Luc Pouly, Arnaud Fauconnier

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Fertility preservation; oocyte vitrification; benign gynecologic disease; modified Delphi method; consensus study

Online: 6 July 2021 (08:17:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0283.v1

Development and Quality Analysis of Instant Soup Mix from Moringa oleifera Pod Powder

Faruk Ansari, Alpana Singh, Sanjay Patidar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Moringa; pods; instant soup mixes; proximate; sensory and storage study

Online: 10 June 2021 (09:08:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0055.v1

Unveiling the Evolution of Innovation Ecosystems: An Analysis of Triple, Quadruple and Quintuple Helix Model Innovation Systems in European Case-studies

Rallou Taratori, Paulina RODRIGUEZ Fiscal, Marie Abigail Pacho, Sesil Koutra, Montserrat Pareja-Eastaway, Dimitrios Thomas

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Case-study analysis; Citizen engagement; Collaborative ecosystem; Governance; Innovation systems; n-Helix model; Smart city

Online: 2 June 2021 (08:49:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0741.v1

MIX-and-Match or Mismatch? Exploring Older Adults’ Perspectives About Zumba Dance and Its Potential Utilization for Dual-Task Training

Laurence Lloyd Parial, Simon Ching Lam, Earl Francis Sumile, Angela Y.M. Leung

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dancing; dual-task; older adults; qualitative study; Zumba; cognition

Online: 31 May 2021 (11:10:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0603.v1

The Landscape Structure of the Dnipro River Islands in Kyiv, Ukraine: the Venetsiansky (Hydropark) Island Case Study

Anastasiia-Olena Pozharska

Subject: Environmental And Earth Sciences, Environmental Science Keywords: the landscape structure; the river island; the Venetsiansky (Hydropark) Island; the genetic landscape study; the European Landscape Classification (LANMAP).

Online: 25 May 2021 (10:27:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0547.v1

The Role of General Practitioners in Suicide Prevention-What you Said and Did then Actually Saved my Life

Marte Styrvold, Tine K. Grimholt

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: General Practitioner; Prevention; Suicide; Qualitative study

Online: 24 May 2021 (09:23:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0545.v1

On-Campus Study: An Experienced Overview and Preference of Undergraduate Students in the UAE

M. Nawaz Brohi, Iftikhar Khan, Arooj Baig, Abdul Basit Khan

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Covid-19; online teaching and learning; face to face study; learning management system

Online: 24 May 2021 (09:01:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0158.v1

Preparation, Characterization and Anti-cancer Activity of Nanostructured Lipid Carriers Containing Imatinib

Hafiz Antar Makeen, Syam Mohan, Mohamed Ahmed Alkasim, Muhammad Hadi Sultan, Ahmed A Albarraq, Rayan A Ahmed, Hassan A. Alhazmi, Mohammad Intakhab Alam

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Imatinib; NLC; Tween 80; SLS; MTT Assay; Release study; Drug delivery; Breast cancer

Online: 10 May 2021 (10:13:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0129.v1

Prolonged Stress Causes Depression in Frontline Workers Facing the COVID-19 Pandemic. A Repeated Cross-Sectional Study

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: infectious disease; organizational justice; stress; loneliness; compassion fatigue; meditation; prayer; insomnia; mental health; perspective study; emergency

Online: 7 May 2021 (09:12:57 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202105.0022.v1

A Case Study on the Perceptions of Forest Owners on Restoring the Forests after a Wildfire in the Treuenbrietzen Forest of Brandenburg, Germany

Regine Frank, Katrin Fröhlich, Somidh Saha

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Wildfire; Private Forest; Reforestation; Southeast Germany; Qualitative Study; Pine Monoculture; Mixed Forest

Online: 4 May 2021 (14:13:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0791.v1

Global Prevalence and Drivers of Dental Students' COVID-19 Vaccine Hesitancy

Abanoub RIAD, Huthaifa ABDULQADER, Mariana MORGADO, Silvi DOMNORI, Michal KOŠČÍK, José João MENDES, Miloslav KLUGAR, Elham KATEEB

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19 Vaccines; Cross-Sectional Studies; Decision Making; Dental Education; Dental Students; International Association of Dental Students; Mass Vaccination; Multicenter Study; Social Determinants of Health

Online: 30 April 2021 (15:26:07 CEST)

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Background: Acceleration of mass vaccination strategies is the only pathway to overcome the COVID-19 pandemic. Healthcare professionals and students have a key role in shaping public opinion about vaccines. This study aimed to evaluate the attitudes of dental students globally towards COVID-19 vaccines and explore the potential drivers for students' acceptance levels; Methods: A global cross-sectional study was carried out in February 2021 using an online ques-tionnaire. The study was liaised by the scientific committee of the International Association of Dental Students (IADS), and data was collected through the national and local coordinators of IADS member organizations. The dependent variable was the willingness to take the COVID-19 vaccine, and the independent variables included demographic characteristics, COVID-19-related experi-ence, and the drivers of COVID-19 vaccine-related attitude suggested by the WHO-SAGE; Results: A total of 6639 students from 22 countries representing all world regions responded to the ques-tionnaire properly. Their mean age was 22.06 ± 2.79 (17-40) years, and the majority were females (70.5%), in clinical years (66.8%), and from upper-middle-income economies (45.7%). In general, 22.5% of dental students worldwide were hesitant, and 13.9% rejected COVID-19 vaccines. The students in low- and lower-middle-income (LLMI) economies had significantly higher levels of vaccine hesitancy compared to their peers in upper-middle- and high-income (UMHI) economies (30.4% vs 19.8%; p < 0.001); Conclusions: The global acceptance level of dental students for COVID-19 vaccines was suboptimal, and their worrisome level of vaccine hesitancy was influenced by the socioeconomic context where the dental students live and study. The media and social media, public figures, insufficient knowledge about vaccines, and mistrust of governments and the pharmaceutical industry were barriers to vaccination. The findings of this study call for further implementation of epidemiology (infectious diseases) education within undergraduate dental curricula.

Preprint ARTICLE | doi:10.20944/preprints202104.0520.v1

Video-Based Communication and its Association with Loneliness, Mental Health and Quality of Life among Older People during the COVID-19 Outbreak

Tore Bonsaksen, Hilde Thygesen, Janni Leung, Mary C. Ruffolo, Mariyana Schoultz, Daicia Price, Amy Østertun Geirdal

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: coronavirus; cross-national study; pandemic; physical distancing; psychological outcomes; social distancing

Online: 19 April 2021 (22:23:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0427.v1

A Multi-Domain Group-Based Intervention to Promote Physical Activity, Healthy Nutrition, and Psychological Wellbeing in Frail Older People: AMICOPE Development Study

Sergi Blancafort Alias, Cesar Cuevas-Lara, Nicolás Martínez-Velilla, Fabricio Zambom-Ferraresi, Maria Eugenia Soto, Neda Tavassoli, Céline Mathieu, Eva Heras Muxella, Pablo Garibaldi, Maria Anglada, Jordi Amblàs, Sebastià Santaeugènia, Joan Carles Contel, Alex Domingo Riau, Antoni Salvà Casanovas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Intrinsic capacity; integrated care; multi-domain intervention; physical exercise; nutrition; psy-chological wellbeing; frailty; complex intervention; intervention development study

Online: 15 April 2021 (18:22:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0419.v1

Preferences for Updates on General Research Results: A Survey of Participants in Genomic Research from Two Institutions

Casey Overby Taylor, Natalie Flaks Manov, Katherine Crew, Chunhua Weng, John J Connolly, Christopher Chute, Daniel Ford, Harold Lehmann, Alanna Rahm, Iftikhar Kullo, Pedro Caraballo, Ingrid Holm, Debra Mathews

Subject: Business, Economics And Management, Accounting And Taxation Keywords: study participation; communication; survey; general research results

Online: 15 April 2021 (14:48:49 CEST)

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Working Paper ARTICLE

Treatment of Urinary Tract Infections With Canephron® in Germany: A Retrospective Database Analysis

Martina Höller, Hubert Steindl, Dimitri Abramov-Sommariva, Florian Wagenlehner, Kurt Naber, Karel Kostev

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Canephron, antibiotic, urinary tract infections, cohort study, herbal treatment

Online: 13 April 2021 (13:11:11 CEST)

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Objective: The goal of the present study was to evaluate the treatment with Canephron® after the diagnosis of acute cystitis or urinary tract infection (UTI) with regards to the risk of a sporadic recurrent UTI, frequent recurrent UTIs, UTI associated sick leave, additional antibiotic prescriptions, and renal complications (pyelonephritis) compared to standard antibiotic treatment. Methods: This retrospective cohort study was based on data from the IMS® Disease Analyzer database (IQVIA), and included outpatients in Germany with at least one diagnosis of acute cystitis or UTI with a prescription of either Canephron® or standard antibiotics between January 2016 and June 2019 in general practitioner (GP), gynecologist, or urologist practices from which data were obtained. Multivariable regression models were used to investigate the association between Canephron® prescription and the amount of sporadic or frequent recurrent UTIs, as well as the duration of UTI associated sick leave, amount of additional antibiotic prescriptions, and cases of pyelonephritis. The effects of Canephron® were adjusted for age, sex, insurance status, and Charlson Comorbidity Score (CCI). Results: 2,320 Canephron® patients and 158,592 antibiotic patients were available for analysis. Compared to antibiotic prescription, Canephron® prescription was significantly associated with less sporadic recurrences of UTI infections 30-365 days after the index date (odds ratio [OR]: 0.66; 95% conﬁdence interval [CI]: 0.58–0.72), as well as with less frequent recurrences of UTI infections (OR: 0.61; 95% CI: 0.49–0.88), and with minor additional antibiotic prescription within 31-365 days (OR: 0.57; 95% CI: 0.52-0.63). No significant differences were observed between the Canephron® and antibiotic cohorts with regard to the likelihood of sick leave (OR: 0.99; 95% CI: 0.86–1.14), new antibiotic prescription within 1-30 days (OR: 1.01; 95% CI: 0.87-1.16) and occurrences of pyelonephritis (Hazard Ratio (HR): 1.00; 95% CI: 0.67-1.48). Conclusion: These real world data show that Canephron® is an effective and safe symptomatic treatment for acute cystitis or UTI. It should be considered as an alternative treatment in particular also to strengthen antimicrobial stewardship strategies.

Preprint ARTICLE | doi:10.20944/preprints202104.0330.v1

Optimal Nutritional Factors Influencing the Duration of Mechanical Ventilation among Critically ill Adults in the Intensive Care Unit

Apinya Koontalay, Wanich Suksatan, Kantapong Prabsangob

Subject: Biology And Life Sciences, Food Science And Technology Keywords: cohort study; critical care; enteral feeding; mechanical ventilation; nutritional status

Online: 13 April 2021 (09:17:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0182.v1

Sterile Insect Technique: Successful Suppression of Aedes Aegypti Field Population in Cuba

René Gato, Zulema Menéndez, Enrique Prieto, Rafael Argilés, Misladys Rodríguez, Waldemar Baldoquín, Yisel Hernández, Dennis Pérez, Jorge Anaya, Ilario Fuentes, Claudia Lorenzo, Keren González, Yudaisi Campo, Jérémy Bouyer

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: sterile insect technique; Aedes aegypti; suppression study; irradiation; vector control

Online: 6 April 2021 (15:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0121.v1

Exposures in the Indoor Environment and Prevalence of Allergic Conditions in the United States of America

Janvier Gasana, Boubakari Ibrahimou, Ahmed N. Albatineh, Mustafa Al-Zoughool, Dina Zein

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Allergy; Asthma; Wheeze; Rhinitis; Home Allergens; Household Dust; Mildew; Cockroach; Dust mites; Pets; Endotoxin; Population Study; Prevalence Study; NHANES

Online: 5 April 2021 (12:23:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0107.v1

Oncogenic Role of miRNA by Environmental Exposure to Plasticizers: A Systematic Review.

Margherita Ferrante, Antonio Cristaldi, Gea Oliveri Conti

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Plasticizers; Cancer; microRNA; in vitro study; PRISMA.

Online: 5 April 2021 (12:04:17 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202103.0764.v1

Creative Legal Study among Undergraduate Medical Students: Sharing Technique from Mae Fah Luang University

Arnon Jumlongkul

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: creative legal study; creativity; medical curriculum; medical student

Online: 31 March 2021 (12:15:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0689.v1

Mobility Patterns of the Portuguese Population During the First Year of the COVID-19 Pandemic: A Longitudinal Study

Tiago Tamagusko, Adelino Ferreira

Subject: Engineering, Civil Engineering Keywords: COVID-19; mobility patterns; Rt; changepoint; modeling; Portugal; Longitudinal Study

Online: 29 March 2021 (12:31:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0685.v1

How People Express Grief by Sharing Photographs on Social Networks: A Comparative Study between Italy and the United States of America

Illene Cupit, Paolo Sapelli, Ines Testoni

Subject: Social Sciences, Anthropology Keywords: death; grief; Internet; photograph; comparative study; social network sites

Online: 29 March 2021 (11:34:58 CEST)

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Working Paper ARTICLE

Presence of Sustainability in the Curricula of the Spanish State Degree in Pedagogy from an Inclusive and Socio-Cultural Approach

Juan A. Rodríguez, Olga M. Alegre

Subject: Business, Economics And Management, Accounting And Taxation Keywords: sustainability; inclusive education; pedagogy; degrees; study plans

Online: 26 March 2021 (10:19:56 CET)

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Working Paper ARTICLE

XEN Glaucoma Implant for Refractory Glaucoma Management: Results and Complications during a 2-year Follow-up

Katarzyna Lewczuk, Joanna Konopińska, Joanna Joablonska, Zofia Mariak, Marek Rękas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: refractory glaucoma; XEN implant; management; retrospective study, MIGS, glaucoma surgery, bleb, subconjunctival stent

Online: 2 March 2021 (14:25:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0411.v1

Loneliness and Its Associated Factors Nine Months After the COVID-19 Outbreak: A Cross-National Study

Tore Bonsaksen, Mariyana Schoultz, Hilde Thygesen, Mary Ruffolo, Daicia Price, Janni Leung, Amy Østertun Geirdal

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: concerns; coronavirus; cross-national study; pandemic; social distancing; social media

Online: 18 February 2021 (11:02:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0092.v1

Different Responses to Stress, Health Practices and Self-care during COVID-19 Lockdown: A Stratified Analysis

Elena Bermejo-Martins, Elkin O. Luis, Ainize Sarrionandia, Martín Martínez, María Sol Garcés, Edwin Y. Oliveros, Cristian Cortés, Maider Belintxon, Pablo Fernández-Berrocal

Subject: Social Sciences, Psychology Keywords: COVID-19; health practices; stress; self-care; cross-cultural study

Online: 2 February 2021 (15:09:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0293.v2

Elevated Proportions of Activated Nk Cells at Diagnosis Predict a Favourable Prognosis in Glioblastoma Patients

Dominik Lobinger, Jens Gempt, Wolfgang Sievert, Melanie Barz, Sven Schmitt, Huyen Nguyen, Stefan Stangl, Caroline Werner, Fei Wang, Zhiyuan Wu, Hengyi Fan, Hannah Zanth, Maxim Shevtsov, Mathias Pilz, Isabelle Riederer, Melissa Schwab, Juergen Schlegel, Gabriele Multhoff

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hsp70; biomarker; glioblastoma; NK cells; clinical study

Online: 26 January 2021 (11:33:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0316.v1

Valproic Acid-Induced Liver Injury: A Case-Control Study from a Prospective Pharmacovigilance Program in a Tertiary Hospital

Enrique Seco Meseguer, Mikel Urroz Elizalde, Alberto M. Borobia, Elena Ramírez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Valproic acid; Drug-induced liver injury; Adverse drug reaction; Case-control study

Online: 18 January 2021 (11:11:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0724.v1

Assessing Face Validity of the Hexcom Model for Capturing Complexity in the Clinical Practice: A Delphi Study

Xavier Busquet-Duran, Eva Maria Jiménez-Zafra, Magda Tura-Poma, Olga Bosch-de la Rosa, Anna Moragas-Roca, Susana Martín Moreno, Emilio Martínez-Losada, Silvia Crespo-Ramírez, Lola Lestón-Lado, Núria Salamero-Tura, Joana Llobera-Estrany, Núria Oriol-Peregrina, Eduardo Moreno-Gabriel, Josep Maria Manresa-Domínguez, Pere Torán-Monserrat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Palliative care; Delphi technique; Needs Assessment; Home Care Services; coordinated care; complexity; methodological study.

Online: 29 December 2020 (09:25:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0516.v1

Comparative Analysis of C++ and Python in Terms of Memory and Time

Farzeen Zehra, Maha Javed, Darakhshan Khan, Maria Pasha

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: benefits; c++; comparative study; execution speed; memory management; python

Online: 21 December 2020 (11:57:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0504.v1

The Videofluorographic Swallowing Study: A Review of Literature

Umar Farooque, Syed Adeel Hassan, SM Ismail Shah, Saba Asif, Muhammad Humayoun Rashid, Abubakar Tauseef

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dysphagia; swallowing impairment; videofluorographic swallowing study; literature review; procedures; indications; normal and critical findings; interfering factors; complications; clinical significance

Online: 21 December 2020 (10:55:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0472.v1

Quantification of Doughnut Economy with the Sustainability Window method: Analysis of Development in Thailand.

Jyrki Luukkanen, Jarmo Vehmas, Jari Kaivo-oja

Subject: Business, Economics And Management, Accounting And Taxation Keywords: sustainability; advanced sustainability analysis (ASA); sustainable development goals (SDGs); indicators; demonstration study; Doughnut economy; Sustainability Window; Thailand

Online: 18 December 2020 (14:51:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0206.v1

An Efficient Synthesis Towards the Core of Crinipellin and Alliacol-B Along With Their Docking Studies

Raghaba Sahu, Ranjan Kumar Mohapatra, Saud I. Al-Resayes, Debadutta Das, Pankaj K. Parhi, Lucia Pintilie, Mohammad Azam

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Crinipellin; Alliacol-B; cycloaddition; dearomatization; docking study

Online: 8 December 2020 (16:58:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0617.v1

Posttraumatic Stress Disorder and Associated Factors During the Early Stage of the COVID-19 Pandemic in Norway

Tore Bonsaksen, Trond Heir, Inger Schou-Bredal, Øivind Ekeberg, Laila Skogstad, Tine K. Grimholt

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: coronavirus; mental health; Norway; population study; PTSD

Online: 24 November 2020 (13:33:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0615.v1

Process and Product innovation in the Eyewear sector: The Role of Industry 4.0 Enabling Technologies for Managing Consumer Health

Federica Murmura, Laura Bravi, Gilberto Santos

Subject: Business, Economics And Management, Economics Keywords: Industry 4.0; Enabling technologies; Eyewear Sector; Case Study; Innovation

Online: 24 November 2020 (13:22:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0556.v1

Striving for Being in the Line of Life: Personal Active Ageing Strategies among Iranian Elder

fatemeh raeesi dehkordi, Ahmad Ali Eslami, Fereshteh Zamani Alavijeh, Hossein Matlabi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Iran; active ageing; elderly; qualitative study

Online: 27 October 2020 (15:14:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0127.v1

The Importance of Collaborative Ecosystems to Boost ‘Smartness’ in Cities

Sesil Koutra, Paulina Rodriguez Fiscal, Marie Abigail Pacho, Rallou Taratori, Pascal Simoens

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Case study; Collaborative ecosystem; Governance; Smart city; Sustainability

Online: 6 October 2020 (12:55:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0732.v1

Cognition Enhancing Effect of Rosemary Plant (Rosmarinus officinalis, L) in Preclinical Studies: A Systematic Review and Meta-Analysis

Shalam Mohamed Hussain, Ayesha Farhana Syeda, Mohammad Alshammari, Sulaiman Alnasser, Naif Alenzi, Samyah Alanazi, Nandakumar Krishnadas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Rosemary; Alzheimer’s disease; cognition; meta-analysis; preclinical study; mild cognitive dysfunction; herbal drugs; rosmarinic acid

Online: 30 September 2020 (10:04:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0607.v1

Whey Proteins Characterization, Free Amino Acids Profile and Antimicrobial Study of Some Dairy Drinks based on Milk Serum

Doina Prodan, Miuța Filip, Mihaela Vlassa, Marioara Moldovan, Rahela Carpa, Viorica Tarmure, and Andreea Simona Popa

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Milk Serum; whey proteins; RP-HPLC-UV; free amino acids; RP-HPLC-FLD; antimicrobial study

Online: 25 September 2020 (11:45:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0339.v1

Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey

Toshiki Sanoh, Eri Eguchi, Tetsuya Ohira, Fumikazu Hayashi, Masaharu Maeda, Seiji Yasumura, Yuriko Suzuki, Hirooki Yabe, Atsushi Takahashi, Kanae Takase, Mayumi Harigane, Takashi Hisamatsu, Keiki Ogino, Hideyuki Kanda, Kenji Kamiya

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Great East Japan Earthquake; disaster; cardiovascular disease; psychological factors; evacuation; prospective study

Online: 16 September 2020 (03:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0588.v1

Honors and Costs of Being Heroes: Risk Factors and Epidemiology of COVID-19 Infection among Health Care Workers of a Severely Hit COVID-19-Referral Hospital in Italy

Marta Colaneri, Viola Novelli, Sara Cutti, Alba Muzzi, Guido Resani, Cristina Monti, Claudia Rona, Anna Maria Grugnetti, Marco Rettani, Francesca Rovida, Valentina Zuccaro, Antonio Triarico, Carlo Marena

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: retrospective cohort study; COVID-19; SARS-CoV-2; health care workers; risk of infection

Online: 27 August 2020 (03:25:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0104.v1

Prevalence and Determinants of Mental Distress During COVID-19 Outbreak in Bangladesh: Evidence from an Online Survey

Shilpi Rani Saha, Md. Mobarak Hossain Khan

Subject: Social Sciences, Behavior Sciences Keywords: coronavirus disease 2019 (COVID-19); pandemic; infectious disease; psychological (mental) consequences; mental distress; outbreak; epidemiological study

Online: 4 August 2020 (16:16:23 CEST)

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Background: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic and life-threatening highly infectious disease. The people of Bangladesh are at high risk of COVID-19 and have already experienced various socio-economic, health and psychological (mental) consequences. Particularly, mental health problems are dominantly reported in the literature and should be controlled. The main objective of this epidemiological study is to assess the mental distress and identify its determinants using online-based survey. Such information is urgently needed to develop feasible strategies for Bangladesh. Methods: An online survey was conducted for this study from May 01 to May 05, 2020. A total of 240 respondents provided self-reported online responses. Respondent’s mental distress was measured by the General Health Questionnaire 12 (GHQ-12) and by the self-rated mental health (SRMH) question. Various kinds of statistical analyses ranging from simple to multivariable logistic recession were performed using SPSS 23.0. Results: About 31.3% and 48.3% of respondents were mentally distressed by GHQ-12 and SRMH question, respectively. Logistic regression analysis revealed that mental distress was significantly higher among those respondents, whose usual activity was affected by the coronavirus (OR = 6.40, 95% CI: 1.87 - 21.90, p<0.001) and whose financial stress was increased due to lockdown (OR = 2.12, 95% CI: 1.01 – 4.46, p<0.05) on GHQ-12. Female sex (OR = 1.97, 95% CI: 1.03 – 3.75, p<0.05) and respondents with poor mental health before the outbreak (OR = 3.38, 95% CI: 1.18 – 9.72, p<0.05) were also significantly affected by mental distress on SRMH. Conclusions: At least thirty percent of the respondents were found to be mentally distressed. Some of the study findings, particularly significant determinants, should be considered while developing strategies to reduce the burden of mental distress among study respondents or similar group in Bangladesh.

Preprint ARTICLE | doi:10.20944/preprints202007.0399.v1

miR-142-3p Reduces the Size, Migration and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-related Pathways that Regulate Cytoskeletal Function

Christin S. Börschel, Anna Stejskalova, Sebastian D. Schäfer, Ludwig Kiesel, Martin Götte

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: microRNA; miR-142-3p; endometriosis; cytoskeleton; integrin; collagen; WASL; ITGAV; endometrial stroma cells; in vitro study

Online: 17 July 2020 (16:08:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0054.v1

Factors Associated with Perception of Risk and Knowledge of Contracting the Novel COVID-19 among Adults in Bangladesh: Analysis of Online Surveys

Tanvir Abir, Nazmul Ahsan Kalimullah, Uchechukwu Levi Osuagwu, Dewan Muhammad Nur -A Yazdani, Abdullah Al Mamun, Taha Husain, Palash Basak, P. Yukthamarani Permarupan, Kingsley Agho

Subject: Social Sciences, Cognitive Science Keywords: COVID-19; Knowledge; Perception of Risk; Pandemic Outbreak; Disease Control; Cross-sectional Study

Online: 5 July 2020 (08:10:36 CEST)

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Preprint DATASET | doi:10.20944/preprints202006.0226.v1

Bias, Confounding, Multiplicity and Researchers’ Degrees of Freedom Combined with Segmented Publications are not Likely to Provide Accurate Estimates of Reality: A Case Study of Two Candidate-Gene Association Reports in the First Episode Psychosis Patients

Vladimir Trkulja

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: candidate-gene association; estimation; bias; confounding; case study

Online: 18 June 2020 (07:50:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0506.v1

The Truth behind the Fallen Leaves: Untold Stories of Unsuccessful LET Examinees

Joseph Dave Pregoner

Subject: Social Sciences, Education Keywords: case study; LET; failure

Online: 29 April 2020 (12:18:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0497.v1

Taking the Inner Route: Spatial and Demographic Factors Affecting Vulnerability to COVID-19 Among 604 Cities from Inner São Paulo State, Brazil

Carlos Magno Castelo Branco Fortaleza, Raul Borges Guimarães, Gabriel Berg de Almeida, Micheli Pronunciate, Cláudia Pio Ferreira

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; Epidemiology; Ecologic study

Online: 28 April 2020 (10:23:16 CEST)

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Objectives: The impact of COVID-19 in metropolitan areas has been extensively studied. The geographic spread to smaller cities is of great concern and may follow hierarchical influence of urban centers. With that in mind, we investigated factors that affect vulnerability of inner municipalities in São Paulo State, Brazil, an area with 24 million inhabitants. Methods: Surveillance data for confirmed COVID-19 cases and admissions for severe acute respiratory disease (SARD) up to April 18^th were recorded for each of 604 municipalities that lay outside São Paulo metropolitan area. Vulnerability was assessed in Multivariable models, including sociodemographic indexes, road distance to the State Capital and the municipalities classification proposed by the Brazilian Institute of Geography and Statistics. Municipalities of great regional relevance were used as reference category for that classification. The outcome of interest for Cox regression was having COVID-cases, with time counting from the first report in São Paulo State. For binomial negative regression models, the outcomes of interest were rates of confirmed COVID-19 cases and admissions for SARD.Results: A total of 198 (32.8%) municipalities had autochthonous COVID-19 cases. In Cox models, affected municipalities were likely to have greater population density (Hazard Ratio[HR] for each 100 inhabitants per square kilometer, 1.07; 95% Confidence Interval [CI], (1.05-1.10)), proportion of inhabitants in urban area (HR, 1.02; 95%CI, 1.00-1.04), higher human development index (HDI, HR for 1%, 1.06; 95%CI, 1.00-1.13) and Gini Index for Inequality of income (HR for 1%, 1.04, 95% CI, 1.00-1.07). On the other hand, distance from the Capital was protective (HR for each 100Km, 0.82; 95%CI, 0.74-0.90). The HR95%[95%CI] also varied negatively according to the categories of influence of major centers (0.41 [0.22-0.77], 0.16 [0.09-0.32], 0.07 [0.03-0.15]). The binomial negative regression models for COVID-19 incidence also detected positive association with population density (Incidence Rate Ratio[IRR], 1.13; 95%CI, 1.07-1.18) and proportion of urban population (IRR, 1.04; 95%CI, 1.01-1.05), protection for cities distant to the Capital (IRR=0.73; 95%CI, 0.68-0.81) and increasing negative association for categories of influence (0.19 [0.09-0.42], 0.07 [0.03-0.15] and 0.03 [0.02-0.08]). Similar findings were detected when we used SARD incidence as outcome.Conclusion: Municipalities with greater population, density and regional influence were more likely to be affected earlier and more intensely by COVID-19. Non-pharmacological measures should be strengthened in those areas of greater risk.

Preprint ARTICLE | doi:10.20944/preprints202004.0280.v1

Effects of 2019 Novel Coronavirus on Male Reproductive System: A Retrospective Study

Jinzhuo Ning, Wei Li, Yuan Ruan, Yuqi Xia, Xiongfei Wu, Ke Hu, Xuhong Ding, Xiaojun Wu, Lilei Yu, Jianlin Zhou, Zhangfan Mao, Wanzhou Xu, Weimin Yu, Fan Cheng

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: COVID-19; 2019-nCoV; male reproductive system; a retrospective study

Online: 16 April 2020 (13:50:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0438.v1

History of Onychophorology, 1826-2020

Julian Monge-Najera

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: history of science; study of invertebrates; research patterns; study of velvet worms

Online: 30 March 2020 (04:46:22 CEST)

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Velvet worms, or onychophorans, include placental species and, as a phylum, have survived all mass extinctions since the Cambrian. They capture prey with an extraordinary adhesive net that appears in an instant. The first naturalist to formally mention them was Lansdown Guilding (1797-1831), a British priest from the Caribbean island of Saint Vincent. His life is as little known as the history of the field he initiated, onychophorology. This is the first general history of onychophorology, and I have divided it into half century periods. The beginning, 1826-1879, was defined by former students of great names in the history of biology, like Cuvier and von Baer. This generation included Milne-Edwars and Blanchard, and the greatest advances came from France, with smaller but still important contributions from England and Germany. In the 1880-1929 period, work concentrated in anatomy, behavior, biogeography and ecology, but of course the most important work was Bouvier’s mammoth monograph. The next half century, 1930-1979, was important for the discovery of Cambrian species; Vachon’s explanation of how ancient distribution defined the existence of two families; Pioneer DNA and electron microscopy from Brazil; and primitive attempts at systematics using embryology or isolated anatomical characteristics. Finally, the 1980-2020 period, with research centered in Australia, Brazil, Costa Rica and Germany, is marked by an evolutionary approach to everything, from body and behavior to distribution; for the solution of the old problem of how they form their adhesive net and how the glue works; the reconstruction of Cambrian onychophoran communities, the first experimental taphonomy; the first country-wide map of conservation status (from Costa Rica); the first model of why they survive in cities; the discovery of new phenomena like food hiding, parental feeding investment and ontogenetic diet shift; and for the birth of a new research branch, Onychophoran Ethnobiology, founded in 2015. While a few names appear often in the literature, most knowledge was produced by a mass of researchers who entered the field only briefly.

Preprint ARTICLE | doi:10.20944/preprints202002.0257.v1

Library and Information Science in the USA and Iran

Michel Nguessan, Shima Moradi

Subject: Social Sciences, Library And Information Sciences Keywords: Library and Information Sciences; comparative study; education; profession

Online: 18 February 2020 (03:34:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0121.v1

Challenges of UAVs Adoption for Agricultural Pesticide Spraying: A Social Cognitive Perspective

Ting-Chu Hsieh, Ming-Chien Hung, Mai-Lun Chiu, Pay-Jiing Wu

Subject: Social Sciences, Behavior Sciences Keywords: unmanned aerial vehicles; smart farming; precision agriculture; technological frames; case study

Online: 12 January 2020 (14:48:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0111.v1

Mineralogical Characterization of Slags from Oiola Site (Biscay) to Assess the Development in Bloomery Iron Smelting Technology from the Roman Period to the Early Middle Ages

Haizea Portillo-Blanco, Maria Cruz Zuluaga, Luis Angel Ortega, Ainhoa Alonso-Olazabal, Juanjo Cepeda-Ocampo, Ana Martínez Salcedo

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: smelting slags; multianalytical study; furnace operating conditions; Roman Period; Early Middle Age; North Spain

Online: 11 January 2020 (14:24:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0363.v1

Dementia Literacy in Greater Bay Area, China: Identifying the At-risk Population and the Preferred Mass Media for Receiving Dementia Information

Angela Yee Man Leung, Alex Molassiotis, June Zhang, Renli Deng, Ming Liu, Iat Kio Van, Cindy Siu U Leong, Isaac S.H. Leung, Doris Y. P. Leung, Xiaoling Lin, Alice Y Loke

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: health literacy; dementia; cross-sectional study; community; Alzheimer's Disease; knowledge

Online: 27 December 2019 (10:34:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0095.v1

Which Traits Make Weeds More Successful in Maize Crops? Insights from a 3-Decade Monitoring in France

Guillaume Fried, Bruno Chauvel, François Munoz, Xavier Reboud

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: trait-based approach; diachronic study; abundance-occupancy relationship; weeds; Zea mays; specialist-generalist

Online: 7 December 2019 (16:45:16 CET)

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Invasion ecology has a long tradition of searching for traits distinguishing alien invasive and non-invasive plants. Surprisingly, this approach has been so far poorly used to understand why some arable weeds are abundant and widespread while others are rare and narrowly distributed. In the present study, we focused on the characteristics of successful weeds occurring in maize fields, one of the most import crop worldwide. Two national weed surveys conducted in France were used to identify increasing and decreasing species based on 175 and 484 surveyed fields in the 1970s and the 2000s, respectively. Weed trait values related to regional frequency, local abundance and specialization to maize were identified with Phylogenetic Generalized Least-Squares (PGLS). We found a positive relationship between regional frequency and local abundance, i.e. the most widespread weeds were also locally more abundant. We highlighted that weeds with the C4 photosynthetic pathway and summer emergence were more abundant, more frequent and more specialized to maize crops. More generally, we highlighted two successful strategies: on the one hand, traits related to a general weediness syndrome with rapid resource acquisition (high SLA and Ellenberg-N) and high colonization capacity (seed longevity, fecundity and wind dispersal), on the other hand, traits related to specific adaptation to spring cultivation (thermophilous species with summer emergence, late flowering and C4 photosynthetic pathway). Deviations from the abundancy-frequency relationships also indicated that species of the Panicoideae sub-family, species with Triazine-resistant populations and neophyte species were more abundant than expected by their regional frequency. To some extent, it is therefore possible to predict which species can be troublesome in maize crops and use this information in weed risk assessment tools to prevent new introductions or favor early detection and eradication. This study showed how tools developed in functional and macro-ecology can be used to improve our understanding of weed ecology and to develop more preventive management strategies.

Preprint REVIEW | doi:10.20944/preprints201912.0054.v1

Social Media Collaboration in Software Project Management

Sania Imran, Faiqa Mehboob, Mehreen Sirshar

Subject: Social Sciences, Media Studies Keywords: Social Media; PMBOK knowledge areas; Delphi Study; Structured Case Study; Team effectiveness

Online: 4 December 2019 (12:37:54 CET)

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Working Paper ARTICLE

Objectives of Sustainable Development and Youth Employment in Colombia

Cristian Castillo, Julimar Da Silva, Sandro Monsueto

Subject: Business, Economics And Management, Economics Keywords: Sustainable Development Goals; Human Capital; youth unemployment; Probit model; multinomial logit model; cohort study

Online: 2 December 2019 (04:42:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0375.v1

Synthesis of Diabetic II Inhibitors Based on 2-mercaptobenzimidazole and their Molecular Docking Study

Muhammad Taha, Fazal Rahim, Shawkat Hayat, Manikandan Selvaraj, Rai Khalid Farooq, Sayed Adnan Ali Shah, Zainul Amiruddin Zakaria

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: synthesis; 2-mercaptabezimidazole; sulfonamide; molecular docking study; α-amylase; sa

Online: 29 November 2019 (10:28:22 CET)

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Working Paper CASE REPORT

Anti-diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients: A Retrospective Study

Masafumi Ito

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: diarrhea; wood creosote; Seirogan; retrospective study; capsule

Online: 6 November 2019 (11:49:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0018.v1

Suicide Overall and Suicide by Pesticide among South Korean Workers: A 15-Year Population-Based Study

Yangwoo Kim, Jeehee Min, Soo-Jin Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide rate; suicide by pesticide; occupational group; suicide prevention; south korea; population-based study

Online: 3 November 2019 (15:46:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0130.v1

Synthesis of novel Triazinoindole-Based-Thiourea Hybrid: α-Glucosidase Inhibitors and Their Molecular Docking Study

Muhammad Taha, Foziah J. Alshamrani, Fazal Rahim, Shawkat Hayat, Hayat Ullah, Khalid Zaman, Syahrul Imran

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Synthesis; triazinoindole; thiosemicarbazide; alpha-glucosidase; molecular docking study; SAR

Online: 13 September 2019 (10:54:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0253.v1

Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design

Yuji Sumii, Kenta Sasaki, Seiji Tsuzuki, Norio Shibata

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: halogen bonding; fluorine; iodine; pentafluorosulfanyl; titration; ab initio calculation; NMR study; drug design

Online: 25 August 2019 (15:41:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0252.v1

Comparative Study of Organic and Inorganic Modification of Chinese Fir Wood Based on the Respiratory Impregnation Method

Ping Li, Yuan Zhang, Yingfeng Zuo, Jianxiong Lu, Guangming Yuan, Yiqiang Wu

Subject: Chemistry And Materials Science, Biomaterials Keywords: Chinese fir wood; sodium silicate; phenol formaldehyde oligomer; respiratory impregnation; comparative study

Online: 25 August 2019 (15:32:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0257.v2

The Zero Energy Idea in District. Application of a Methodological Approach in the Case Study of Epinlieu (Mons)

Sesil KOUTRA, Claire Pagnoule, Fivos Nikolaos Galatoulas, Ali Bagheri, Thomas Waroux, Vincent Becue, Christos S. Ioakimidis

Subject: Social Sciences, Sociology Keywords: Case study; District; Energy; Structure; Zero

Online: 24 July 2019 (11:53:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0102.v1

The Brain Origin of Neonatal Microglia Determines the Content of Exosomes and Biological Function

Adriana-Natalia Murgoci, Khalil Mallah, Soulaimane Aboulouard, Christophe Lefebvre, Milan Cizek, Isabelle Fournier, Dasa Cizkova, Michel Salzet

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: microglia exosomes; 3D culture; proteomic study; glioma; neurites outgrowth

Online: 8 July 2019 (04:26:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0268.v1

Study on the Spatial Pattern of Innovation Output and Influencing Factors in Guangdong-Hong Kong-Macao Greater Bay Area

Dongliang Yang, Chunfeng Li

Subject: Business, Economics And Management, Economics Keywords: Guangdong-Hong Kong-Macao Greater Bay Area; innovation sustainable development; innovation output; spatial pattern; empirical study

Online: 22 May 2019 (08:45:37 CEST)

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Working Paper ARTICLE

An Ontology to Standardize Nutritional Epidemiologic Research Output: From Paper-Based Standards to Linked Content

Chen Yang, Henry Ambayo, Bernard De Baets, Patrick Kolsteren, Nattapon Thanintorn, Dana Hawwash, Jildau Bouwman, Antoon Bronselaer, Filip Pattyn, Carl Lachat

Subject: Biology And Life Sciences, Food Science And Technology Keywords: ontology; nutritional epidemiology; minimal data information; data quality descriptors; study reporting guidelines; Semantic Web

Online: 15 May 2019 (05:51:53 CEST)

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Working Paper ARTICLE

Trends and Correlates of Excessive Body Weight in Czech Adolescents in Relation to Family Socioeconomic Status over a 16-Year Study Period (2002–2018)

Erik Sigmund, Petr Badura, Dagmar Sigmundová, Jaroslava Voráčová, Vladimír Jr. Hobza, Jiří Zacpal, Zdenek Hamrik, Jan Pavelka, Zuzana Půžová, Michal Kalman

Subject: Social Sciences, Education Keywords: obesity; overweight; socioeconomic status; Health Behaviour of School-aged Children (HBSC) Study; trends

Online: 22 April 2019 (11:50:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0130.v1

Maternal Body Mass Index and Gestational Weight Gain and Their Association with Pregnancy Complications and Perinatal Conditions

Martin Simko, Adrian Totka, Diana Vondrova, Martin Samohyl, Jana Jurkovicova, Michal Trnka, Anna Cibulkova, Juraj Stofko, Lubica Argalasova

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: retrospective hospital-based study, overweight, obesity, pregnancy pathologies, caesarean section, weight gain

Online: 10 April 2019 (12:34:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0094.v1

Effects of Vegetable Cultivation on Health: A Qualitative Study of the Health Effects Other than Increasing Vegetable Intake

Daisuke Machida, Tohru Yoshida

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Keywords: vegetable cultivation; health; physical health; mental health; social well-being; qualitative study; adult; Japan

Online: 8 April 2019 (12:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0241.v1

Reasons Why Vegetable Cultivation Increases or does not Increase Vegetable Intake Among Adult Vegetable Growers Living in a City in Gunma Prefecture, Japan: A Qualitative Study

Daisuke Machida, Tohru Yoshida

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: vegetable intake; vegetable cultivation; qualitative study; Japanese, adults

Online: 26 March 2019 (10:49:20 CET)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201903.0111.v1

Cyber Security Framework for the Internet-of-Things in Industry 4.0

Petar Radanliev, Rafael Mantilla Montalvo, Stacy Cannady, Razvan Nicolescu, Dave De Roure, Jason R.C. Nurse, Michael Huth

Subject: Engineering, Control And Systems Engineering Keywords: Industry 4.0., Internet of Things, case study, cyber security framework

Online: 8 March 2019 (15:27:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0067.v1

Survey Study on Attitudes to Multi-Dimensional Sustainable Development Ladder with UK MSc Students

Gavin Melles

Subject: Social Sciences, Education Keywords: education for sustainable development, postgraduate students, united kingdom, survey study

Online: 7 February 2019 (10:15:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0162.v2

Ankylosing Spondylitis Is Associated with Risk of New Onset Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study

Tsao Chien-Han, Jing-Yang Huang, Hsin-Hsin Huang, Yao-Min Hung, James Cheng-Chung Wei, Hung Yin Tsan

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ankylosing spondylitis; obstructive sleep apnea; population-based cohort study

Online: 17 January 2019 (04:52:29 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201901.0126.v1

Mapping Quantitative Trait Loci onto Chromosome-scale Pseudomolecules in Flax

Frank M. You, Sylvie Cloutier

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: flax; association mapping; genome-wide association study (GWAS); simple sequence repeat (SSR); single nucleotide polymorphism (SNP); quantitative trait loci (QTL); chromosome-scale pseudomolecules

Online: 14 January 2019 (07:19:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201812.0267.v1

Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins

Gustavo C. Román, Oscar Mancera-Páez, Camilo Bernal

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; CTH gene; DNA methylation; epigenetics; epigenome-wide association study; methylome; MTHFR gene; nutrition; S-adenosylmethionine; vitamin B complex

Online: 24 December 2018 (04:48:53 CET)

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