Ning, J.; Li, W.; Ruan, Y.; Xia, Y.; Wu, X.; Hu, K.; Ding, X.; Wu, X.; Yu, L.; Zhou, J.; Mao, Z.; Xu, W.; Yu, W.; Cheng, F. Effects of 2019 Novel Coronavirus on Male Reproductive System: A Retrospective Study. Preprints2020, 2020040280. https://doi.org/10.20944/preprints202004.0280.v1
Ning, J., Li, W., Ruan, Y., Xia, Y., Wu, X., Hu, K., Ding, X., Wu, X., Yu, L., Zhou, J., Mao, Z., Xu, W., Yu, W., & Cheng, F. (2020). Effects of 2019 Novel Coronavirus on Male Reproductive System: A Retrospective Study. Preprints. https://doi.org/10.20944/preprints202004.0280.v1
Ning, J., Weimin Yu and Fan Cheng. 2020 "Effects of 2019 Novel Coronavirus on Male Reproductive System: A Retrospective Study" Preprints. https://doi.org/10.20944/preprints202004.0280.v1
A novel and highly pathogenic coronavirus (2019-nCoV)-induced pneumonia spread worldwide in a short time. However, studies on the effects of 2019-nCoV on the male reproductive system are limited. The aim of this study is to describe the clinical characteristics of the male reproductive system of COVID-19 patients and to explore the presence of 2019-nCoV in semen. Retrospective, single-center case series of 112 male patients with confirmed COVID-19 who were admitted to Renmin Hospital of Wuhan University from January 2 to March 7, 2020. Demographic data, symptoms and signs related to the male reproductive system, throat swabs and semen samples were collected and analyzed. 2019-nCoV RNA measured in throat swab and semen samples. The organ distribution of ACE2 mRNA and protein in human tissue on The Human Protein Atlas portal and investigated immunohistochemistry (IHC) images of the testis. The HPA dataset revealed relatively high levels of ACE2 protein and RNA expression in the testis. A total of 3 severe COVID-19 patients (2.7%) presented with orchidoptosis, while no patients experienced other symptoms or signs related to the male reproductive system. The analysis of 2019-nCoV RNA in semen included 17 patients with fertility needs. Among these patients, 9 (52.9%) remained positive for 2019-nCoV according to throat swab analysis, and 8 (47.1%) became negative. In the semen 2019-nCoV analysis, all 17 patients were negative for the N gene and ORF1ab gene. In view of the potential impairment, long-term follow-up for male COVID-19 patients with fertility needs is of great significance.
COVID-19; 2019-nCoV; male reproductive system; a retrospective study
Medicine and Pharmacology, Urology and Nephrology
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