Working Paper Article Version 1 This version is not peer-reviewed

Genome-Wide Study Suggests an Association of the Enhancer rs10419198 for PRR12 Gene with Disordered Eating Behavior in the Mexican Population

Version 1 : Received: 7 October 2021 / Approved: 8 October 2021 / Online: 8 October 2021 (14:23:39 CEST)

How to cite: Martínez-Magaña, J.J.; Hernandez, S.; Garcia, A.R.; Cardoso-Barajas, V.; Sarmiento, E.; Camarena, B.; Caballero, A.; Gonzalez, L.; Villatoro-Velazquez, J.A.; Medina-Mora, M.E.; Bustos-Gamiño, M.; Fleiz-Bautista, C.; Tovilla-Zarate, C.A.; Juárez-Rojop, I.E.; Nicolini, H.; Genis-Mendoza, A.D. Genome-Wide Study Suggests an Association of the Enhancer rs10419198 for PRR12 Gene with Disordered Eating Behavior in the Mexican Population. Preprints 2021, 2021100146 Martínez-Magaña, J.J.; Hernandez, S.; Garcia, A.R.; Cardoso-Barajas, V.; Sarmiento, E.; Camarena, B.; Caballero, A.; Gonzalez, L.; Villatoro-Velazquez, J.A.; Medina-Mora, M.E.; Bustos-Gamiño, M.; Fleiz-Bautista, C.; Tovilla-Zarate, C.A.; Juárez-Rojop, I.E.; Nicolini, H.; Genis-Mendoza, A.D. Genome-Wide Study Suggests an Association of the Enhancer rs10419198 for PRR12 Gene with Disordered Eating Behavior in the Mexican Population. Preprints 2021, 2021100146

Abstract

Eating disorders (ED) are characterized by alterations in eating behavior. The genetic factors shared between ED diagnoses have been underexplored. The present study aimed to perform a genome-wide association study on individuals with disordered eating behaviors in the Mexican population, blood methylation quantitative trait loci (blood-meQTL) analysis, and in silico function prediction by different algorithms. The analysis included a total of 1803 individuals. Genome-wide association study and blood-meQTL analysis were performed by logistic and linear regression. In silico functional variant prediction, phenome-wide, and transcriptome-wide association studies by different algorithms were analyzed. In the genome-wide association study, we identified 44 single-nucleotide polymorphisms (SNP) associated at a nominal value and 7 blood-meQTL at a genome-wide umbral. The SNPs were enriched in genome-wide associations of the metabolic and immunologic domains. In the in silico analysis, the SNP rs10419198 located on an enhancer mark could change the expression of PRR12 on blood, adipocytes, and brain areas that regulate food intake. The present study supports the previous associations of genetic variation in the metabolic domain with ED.

Keywords

feeding and eating disorder; genome-wide association study; methylation quantitative trait loci

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