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Preprint ARTICLE | doi:10.20944/preprints202305.1941.v1

Coping as a Mediator between Attachment and Depression either in Pregnancy or in the Early Postpartum Period: A Structural Equation Modelling Approach

Mario Altamura, Ivana Leccisotti, Laura De Masi, Fiammetta Gallone, Livia Ficarella, Melania Severo, Simona Biancofiore, Antonio Ventriglio, Annamaria Petito, Giuseppe Maruotti, Luigi Nappi, Antonello Bellomo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Perinatal Depression; Attachment Style; Coping Strategies; Gender Medicine; Women Health

Online: 26 May 2023 (14:42:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1574.v1

Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients

Suet-Kei Wu, Wei-Jen Chen, Jane Pei-Chen Chang, Ta-Wei Guu, Ming-Che Hsin, Chih-Kun Huang, David Mischoulon, Lucile Capuron, Kuan-Pin Su

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: omega-3 polyunsaturated fatty acids (n-3 PUFAs); major depressive disorder (MDD); obesity; metabolic dysregulation; comorbidities

Online: 23 May 2023 (04:54:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1223.v1

Microbiome-Gut-Mucosal-Immune-Brain Axis and Autism Spectrum Disorder (ASD): A Novel Proposal of the Role of Gut Microbiome in ASD Aetiology

Amapola De Sales-Millán, José Félix Aguirre-Garrido, Rina María González-Cervantes, Jose Antonio Velázquez-Aragón

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Microbiome-Gut-Brain axis; ASD; dysbiosis; gastrointestinal functions; Immune System; and Neuroimmunogastroenterology

Online: 17 May 2023 (10:11:01 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202305.0554.v1

Development and Evaluation of Novel Apomorphine and Quetiapine Combinational Formulation for Parkinson’s Disease in Rat: New Era (Possibilities) for Pre – Clinical Protocol Concept Review

Minesh Patel

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Parkinson’s Disease; Pre-Clinical Protocol; Novel Combinational Formulation; In Vivo Model; In Vivo Study

Online: 9 May 2023 (03:49:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0378.v1

Potential Mechanisms of Action and Outcomes of Equine-Assisted Services for Veterans with a History of Trauma: A Narrative Review of the Literature

William R Marchand

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Veterans; psychiatric disorders; equine-assisted services; PTSD; psychotherapy incorporating horses; military sexual trauma

Online: 6 May 2023 (05:14:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1086.v1

Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes

Fabian Huth, Leonardo Tozzi, Michael Marxen, Philipp Riedel, Kyra Bröckel, Julia Martini, Christina Berndt, Cathrin Sauer, Christoph Vogelbacher, Andreas Jansen, Tilo Kircher, Irina Falkenberg, Florian Thomas Odenthal, Martin Lambert, Vivien Kraft, Gregor Leicht, Christoph Mulert, Andreas J. Fallgatter, Thomas Ethofer, Anne Rau, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Silvia Biere, Felix Bermpohl, Jana Fiebig, Thomas Stamm, Christoph U. Correll, Georg Juckel, Vera Flasbeck, Philipp Ritter, Michael Bauer, Andrea Pfennig, Pavol Mikolas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: bipolar risk; hippocampal subfields; amygdala nuclei; MRI; machine learning

Online: 28 April 2023 (03:03:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0832.v1

Age of Onset Moderates the Association Between Total Antioxi-Dant Capacity and Cognitive Deficits in Patients With Drug-Naïve Schizophrenia

Jiaxin Li, Deyang Li, Junru Guo, Dongmei Wang, Xiangyang Zhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; age of onset; TAOC; cognitive function; oxidative stress

Online: 24 April 2023 (06:22:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0627.v1

The Association between Coffee and Tea Consumption at Midlife and Risk of Dementia Later in Life: The HUNT Study

Denise Abbel, Bjørn Olav Åsvold, Marit Kolberg, Geir Selbæk, Raymond Noordam, Håvard Kjesbu Skjellegrind

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: coffee consumption; tea consumption; mild cognitive impairment; dementia; Alzheimer’s disease; nutrition; epidemiology; apolipoprotein E; MCI

Online: 20 April 2023 (07:55:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0611.v1

The Concept of “Hypersexuality” in the Boundary Between Physiological and Pathological Sexuality

Giulio Perrotta

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Hypersexuality; Nymphomania; Satyriasis; Personality disorders; Bipolarism; Sexual arousal

Online: 20 April 2023 (05:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0572.v1

The Michigan Clinical Consultation and Care model (MC3 Perinatal): A Novel Approach to Perinatal Mental Health Care

Maria Muzik, Rena A. Menke, Meriam Issa, Chelsea Fisk, Jordan Charles, Jennifer M. Jester

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: perinatal mental health, integrated care, psychiatry consultation, collaborative care, implementation science

Online: 19 April 2023 (08:35:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0564.v1

Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants

Carmine Tomasetti, Gianna Autullo, Andrea Ballerini, Andrea De Bartolomeis, Bernardo Maria Dell'Osso, Alessio Fiorentini, Federico Tonioni, Vincenzo Villari, Domenico De Berardis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; trazodone; neurobiology; emotion

Online: 19 April 2023 (07:52:17 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202304.0488.v1

The Trajectory of Depression through Disenfranchised Grief in Young Widows in Times of COVID-19: A Case Report from the Rural Population in India

Shagufta Nasir, Lydia Gimenez Llort

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: disenfranchised grief; widowhood; rural India; COVID-19 pandemic; bioecological model; coping

Online: 18 April 2023 (05:02:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0170.v1

Investigating the Efficacy of Transcranial Direct Current Stimulation in Managing ADHD and Co-occurring Conditions

Syed Adnan Ali, Syed Noor Ali, Rehan Khan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Neuromodulation; Brain Stimulation; Transcranial Direct Current Stimulation; Neurodevelopment Disorder; ADHD; ADD

Online: 10 April 2023 (10:39:24 CEST)

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ADHD, a neurodevelopmental condition, is distinguished by a triad of symptoms including inattention, hyperactivity, and impulsivity. It is frequently accompanied by comorbidities such as anxiety, depression, and learning disabilities. As a result, clinicians often face challenges in accurately diagnosing ADHD and differentiating it from other conditions. As a prospective remedy for ADHD, scientists have investigated Transcranial Direct Current Stimulation (tDCS), a non-invasive technique of stimulating the brain. It involves applying low-intensity electrical currents to specific regions of the brain to modulate neural activity. This review paper aims to provide an overview of the comorbidities associated with ADHD and the differential diagnosis of the condition. It also explores the potential of tDCS as a treatment option for ADHD, including its mechanisms of action and efficacy in improving ADHD symptoms. The comorbidities discussed in this review include anxiety disorders, mood disorders, and substance use disorders. These comorbidities are frequently seen in individuals with ADHD and can complicate the diagnosis and treatment of the condition. The paper also highlights the importance of considering comorbidities when assessing ADHD, as well as the potential impact of these conditions on treatment outcomes. The differential diagnosis section of the paper explores conditions that can present with symptoms similar to ADHD, such as anxiety disorders, mood disorders, and learning disabilities. It emphasizes the need for a thorough assessment and differential diagnosis to identify ADHD and differentiate it from other conditions accurately. The final section of the paper discusses the potential of tDCS as a treatment option for ADHD. It examines the mechanisms of action of tDCS and its efficacy in improving ADHD symptoms, including attention, hyperactivity, and impulsivity. It also explores the potential for tDCS to improve comorbid conditions associated with ADHD. Overall, this review provides a comprehensive overview of comorbidities and differential diagnoses in ADHD and the potential of tDCS as a treatment option. The paper highlights the importance of a thorough assessment and personalized treatment plan for individuals with ADHD, particularly those with comorbidities.

Preprint REVIEW | doi:10.20944/preprints202303.0533.v1

Biomarkers of neurodegeneration in post-traumatic stress disorder: an integrative review

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: post-traumatic stress disorder; dementia; Parkinson’s disease; β-amyloid; inflammation; hippocampus; white matter integrity; genetics

Online: 31 March 2023 (02:12:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0392.v1

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia

Takashi Uchino, Ryo Okubo, Youji Takubo, Akiko Aoki, Izumi Wada, Naoki Hashimoto, Satoru Ikezawa, Takahiro Nemoto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ACSo; cognitive function; depression; PDQ; psychosis; real-world functioning; schizophrenia; SFS; social functioning

Online: 22 March 2023 (06:36:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0096.v1

Depression Associated With Intrafamily Violence in Pregnant Women Treated at a Peruvian Health Center, 2022

Ximena Cardenas-Barrios, Zaida Zagaceta-Guevara, Victor Moquillaza-Alcantara

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: violence; depression; pregnancy; primary prevention; mental health

Online: 6 March 2023 (06:48:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0020.v1

Impact of SARS-Cov-2 on Clinical Trial Unit Workforce in the United Kingdom: An Observational Study

Gayathri Delanerolle, Jintong Hu, Heitor Cavalini, Lucy Yardley, Katharine Barnard-Kelly, Kathryn Elliot, Vanessa Raymont, Shanaya Rathod, Jian Qing Shi, Peter Phiri

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; Clinical trials; Mental health; Vaccination; CTU workforce

Online: 1 March 2023 (10:44:52 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202302.0464.v1

Cannabidiol, NegEnt and Panic Disorder

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cannabidiol; liposomal cannabidiol; NegEnt; panic disorders; cognitive psychotherapy; alprazolam

Online: 27 February 2023 (09:07:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0035.v2

Estimating Prevalence of Bereavement, Its Contribution to Risk for Binge Drinking, and Other High-Risk Health States in a State Population Survey, 2019 Georgia Behavioral Risk Factor Surveillance Survey

Toni Miles, Changle Li, M. Mahmud Khan, Rana Bayakly, Deborah Carr

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: BRFSS; Binge Drinking; Population Survey; Bereavement; SDG#3; Mental Health

Online: 22 February 2023 (14:30:30 CET)

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Binge drinking is a pattern of alcohol abuse. Its prevalence and associated risk factors are not well documented. Heavy drinking, on the other hand, has a well-studied association with bereavement . This report uses a cross-sectional, population-based survey to estimate prevalence of bingeing and its association with new bereavement. Bingeing is defined as 4 or more drinks (women) or 5 or more drinks (men) in a 2-to-4-hour setting. For the first time, the Georgia Behavioral Risk Factor Surveillance Survey (BRFSS) included a bereavement item, ‘Have you experienced the death of a family member or close friend in the years 2018 or 2019?’. Methods: Georgia BRFSS is a complex sampling survey administered annually. It is designed to represent the 8.1 million persons in the U.S. state of Georgia aged 18 years and older. Alcohol consumption patterns are routinely measured in the common core. In the 2019 field survey, the state added a new item probing for bereavement in the prior 24 months predating the pandemic of COVID-19. Imputation and weighting techniques were applied to yield population prevalence rates of new bereavement, bingeing, and their co-occurrence with other high-risk health states. Models, adjusted for age, gender, and race were used to estimate the risk for other unhealthy behaviors posed by the co-occurrence of bereavement and bingeing. Results: In Georgia, bereavement is common (45.8 %), and alcohol consumption is common (48.8 %). Bereavement and alcohol use co-occurred among 1,796,817 persons (45 % of all drinkers). The subset of co-occurring bereavement and binging totaled 608,282 persons. Within this group, the highest rates of bereavement were associated with death of a friend / neighbor (30.7%) or 3 plus deaths (31.8%). Conclusions: While bingeing is a known risk to public health, its co-occurrence with recent bereavement is a new observation. Public health surveillance systems need to monitor this co-occurrence to protect both individual and societal health. In a time of global bereavement, documenting its influence on binge drinking can support the work towards Sustainable Goal #3 – Good health and Well-Being. Keywords: BRFSS, Binge Drinking, Population Survey, Bereavement, SDG#3. Mental Health

Preprint REVIEW | doi:10.20944/preprints202302.0380.v1

Treating Depression in Clinical Practice: New Insights on the Multidisciplinary Use of Tradozone

Umberto Albert, Carmine Tomasetti, Camillo Marra, Francesca Neviani, Alessandro Pirani, Daiana Taddeo, Orazio Zanetti, Giuseppe Maina

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; neurological disorders; dementia; primary care

Online: 22 February 2023 (08:42:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0245.v1

Applicability of the Hungarian Version of the Test Your Memory in General Practice for Screening Mild Cognitive Impairment and Early Stage Dementia

Szabolcs Garbóczy, András Mohos, Anikó Égerházi, Anita Szemán-Nagy, János András Zsuffa, Szilvia Heim, Viktor Rekenyi, László Róbert Kolozsvári

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dementia; mild cognitive impairment; elderly; primary care; GP; family physician

Online: 15 February 2023 (01:36:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0225.v1

The Brain Overwork Scale: A Population-Based Cross-Sectional Study on the Psychometric Properties of a New 10-Item Scale Assessing Mental Distress

Battuvshin Lkhagvasuren, Tetsuya Hiramoto, Enkhnaran Tumurbaatar, Enkhjin Bat-Erdene, Gantsetseg Tumur-Ochir, Vijay Viswanath, Joshua Corrigan, Tsolmon Jadamba

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: health psychology; mental distress; stress; population; psychometric property; validation; Mongolia

Online: 14 February 2023 (03:03:17 CET)

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Abstract: (1) Background: We hypothesized measuring the extent of brain overwork can extrapolate the burden of mental distress. This study aimed to develop a scale that measures mental distress and validate it in the general population. (2) Methods: In this population-based cross-sectional study, we recruited a total of 739 adults aged 16-65 years from 64 sampling centers of a clinical cohort across Mongolia to validate a 10-item self-report questionnaire. Internal consistency was measured using the McDonald’s ω. Test-retest reliability was analyzed using intraclass correlation coefficients. Construct and convergent validities were examined using the principal component analysis (PCA) and confirmatory factor analysis (CFA). Hospital Anxiety and Depression Scale (HADS) and the abbreviated version of the World Health Organization Quality of Life (WHOQOL-BREF) were used to evaluate the criterion validity. (3) Results: Among the participants, 70.9% were women, 22% held a bachelor's degree or higher, 38.8% were employed, and 66% were married. The overall McDonald’s ω coefficient was 0.861 demonstrating evidence of excellent internal consistency. The total intraclass correlation coefficient of the test-retest analysis was 0.75, indicating moderate external reliability. PCA and CFA established a three-domain structure that provided an excellent fit to the data (RMSEA=0.033, TLI=0.984, CFI=0.989, χ2=58, p=0.003). This 10-item scale, the Brain Overwork Scale (BOS-10), determines mental distress in three dimensions: Excessive Thinking, Hypersensitivity, and Restless Behavior. All items had higher item-total correlations with their corresponding domain than the other domains, and correlations between the domain scores ranged from 0.547–0.615. The BOS-10 correlated with the HADS, whereas it was inversely correlated with the WHOQOL-BREF. (4) Conclusions: The results suggest that the BOS-10 is a valid and reliable instrument for assessing mental distress in the general population. The current findings also demonstrate that the BOS-10 is quantitative, simple, and applicable for large-group testing.

Preprint REVIEW | doi:10.20944/preprints202302.0124.v1

Temporal Stability of the Dynamic Resting-State Functional Brain Network: a Narrative Review of Current Measures and Clinical Research Progress

Yicheng Long, Xiawei Liu, Zhening Liu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: connectome; dynamic functional connectivity; dynamic brain network; schizophrenia; major depressive disorder; bipolar disorder

Online: 7 February 2023 (07:23:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0119.v1

Group Independent Components Underpin Responses to Items from a Depression Scale

Drozdstoy Stoyanov, Vladimir Khorev, Rositsa Paunova, Sevdalina Kandilarova, Semen Kurkin, Vince D. Calhoun

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: functional MRI; group independent component analysis; depression

Online: 7 February 2023 (04:22:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0108.v1

Effects of Health Anxiety, Social Support, and Coping on Dis-sociation with Mediating Role of Perceived Stress during the COVID-19 Pandemic

László Róbert Kolozsvári, Viktor Rekenyi, Szabolcs Garbóczy, Ágnes Hőgye-Nagy, Anita Szemán-Nagy, Mohamed Sayed-Ahmad, Katalin Héjja-Nagy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: perceived stress; social support; health anxitety; coping; lockdown; COVID-19; international stu-dents; domestic students

Online: 7 February 2023 (02:22:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0008.v1

Factors Associated with Extended Length of Stay for Paediatric Mental Health Presentations to Emergency Departments in South Western Sydney, Australia

Jahidur Rahman Khan, James Rufus John, Paul M. Middleton, Yao Huang, Ping-I Lin, Nan Hu, Bin Jalaludin, Paul Chay, Raghu Lingam, Valsamma Eapen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: extended length of stay; emergency department; mental health

Online: 1 February 2023 (06:01:41 CET)

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Background: Evidence suggests that children and young people (CYP) who present to the emergency department (ED) for mental health (MH) difficulties may have extended lengths of stay (LOS); however, there is a paucity of research in Australia regarding the factors associated with extended LOS. This study aimed to determine the factors associated with extended LOS for paediatric MH-related presentations to the EDs in South Western Sydney (SWS), a multicultural community in Australia. Methods: We analysed electronic medical records (eMR) of 7,409 MH-related ED encounters of CYP aged 0 up to 18 years from all six public hospitals in SWS from January 2016 to April 2022. Extended LOS was defined as encounters of more than 4 hours. We assessed factors associated with extended LOS using a multilevel logistic regression model, accounting for hospital-level clustering. Results: Approximately 57.6% of all ED presentations for paediatric MH involved extended LOS. ED presentations by adolescents (adjusted odds ratio (AOR) 2.23, 95% CI 1.20-4.17 for 12-14 years and AOR 2.69, 95% CI 1.44-5.00 for 15-17 years), and patients with a preferred language other than English (AOR 1.47, 95% CI 1.15-1.89) had increased odds of extended LOS compared to their counterparts. Deliberate self-harm related presentations, the most commonly presented MH condition, had higher odds of extended LOS than other MH-related presentations (AOR 1.77, 95% CI 1.59-1.98). Patients with MH presentations that required urgent evaluation (triage levels 1-2) had higher odds of extended LOS (AOR 1.38, 95% CI 1.15-1.65) compared to triage level 3, whereas those with triage levels 4-5 had lower odds (AOR 0.66, 95% CI 0.58-0.74). Further, patients with MH-related presentations that came by ambulance (compared to other mode of presentations) and presentations that happened at night and late at night (compared to early morning and daytime presentations). The odds of extended LOS were considerably lower during the COVID-19 period compared to the pre-COVID-19 period (AOR 0.74, 95% CI 0.67-0.82). Additionally, extended paediatric LOS for MH issues in the ED showed notable hospital-level heterogeneity. Conclusion: A large proportion of extended LOS in ED and sociodemographic disparities reflect inequality in access to paediatric MH care. Our findings highlight the need for equitable distribution of resources directed towards at-risk CYP to improve MH outcomes and reduce health system burden.

Preprint ARTICLE | doi:10.20944/preprints202301.0378.v1

Using a Digital Technology Intervention to Promote Psychological Health Outcomes in Adolescents: A Feasibility Study

Nopporn Vongsirimas, Sirada Kesornsri, Phuangphet Kaesornsamut, Wareerat Thanoi, Sudarat Pianchob, Sathaka Pimroon, Supapak Phetrasuwan, Thineerat Thavorn, Piyanee Klainin-Yobas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mobile Application; Psychological well-being; Depressive symptoms; Adolescents

Online: 22 January 2023 (04:26:40 CET)

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Background: Depressive symptoms often occurred during the adolescence period. This situation affected their psychological well-being, which is an important element for a positive youth development. Thus, there is an urgent need to prevent such mental health problems and promote psychological health outcomes among adolescents. Mobile health has been created as a platform to promote mental health to adolescents to ensure ongoing safety and effectiveness. Despite the positive evidence to support the mobile health, tailored mobile health to promote mental health and prevent psychological symptoms among adolescents in Thailand is lacking.This study aimed to assess the feasibility and acceptability of delivering digital technology intervention prototype called “MU-My-Mind Mobile Application (MU-My-mind App)” among Thai adolescents and evaluate the efficacy of this application in improving psychological health outcomes. Materials and Methods: This quasi-experimental research was conducted in secondary school students in Thailand. A convenience sample was recruited and participants were asked to download the MU-My-Mind App on their smart phone. Health outcomes were also evaluated by self-administered questions and focus group interview at baseline and post-intervention. Feasibility and acceptability were assessed. Quantitative data were analyzed by descriptive statistics and pair t-test. Qualitative data were analyzed by thematic analysis. Results: Thirty students completed the MU-My-Mind application. Quantitative data suggested significant improvements on mindfulness, psychological well-being, depression, anxiety and stress. Qualitative data derived into six themes: a) overall feedback of the program, b) learning to manage stress and challenges, c) elevating relaxation responses and calmness, d) heightened mindfulness and concentration, e) increased awareness and management of emotions, and f) altering perspectives and managing thoughts. Overall, data suggested the acceptability and feasibility of the intervention. Conclusion: The “MU My Mind Mobile Application” prototype was demonstrated feasible and well acceptable among Thai adolescents to promote their psychological health outcome. However, there are some limitation and suggestion emerged during this pilot testing. Future research should be explored in a larger sample size with comparison control group and over a longer duration with a range of diverse samples to ensure the efficacy of this application.

Preprint ARTICLE | doi:10.20944/preprints202301.0292.v1

Prevalence and Associated Factors of Internet Gaming Disorder among Residents in Saudi Arabia: A Cross-Sectional Study

Shuliweeh Alenezi, Hamzah Al fiaar, Muhammad Aldossary, Ibrahim Alnafisah, Samar Binkheder, Ibrahim A. Almaghlouth, Aqeel Alkhiri

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: gaming; IGD; adolescents; children; adult; internet; Saudi Arabia

Online: 17 January 2023 (01:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0185.v1

Exploratory Factor Analysis of a French Adapted Version of the Substance Abuse Attitude Survey Among Medical Students in Belgium

Lou Richelle, Michelle Dramaix, Nadine Kacenelenbogen, Charles Kornreich

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Substance Use Disorder; Attitudes; Medical Students; Education; Assessment; Stigma

Online: 10 January 2023 (11:40:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0035.v1

Measuring Bereavement Prevalence in a Complex Sampling Survey: The 2019 Georgia Behavioral Risk Factor Surveillance System (BRFSS).

Changle Li, Toni P. Miles, Ye Shen, Rana Bayakly, Moses Ido, M. Mahmud Khan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: BRFSS; Bereavement; Grief; Mental Health; Physical Health; Population Surveillance; Social de-terminants of health; Multiple Imputation; Screening

Online: 4 January 2023 (01:54:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0018.v1

Postpartum depression and Health: Role of Perceived Social Support among Women.

Samrah Jamshaid, Najma Iqbal Malik, Irfan Ullah, Sundas Saboor, Fauzia Arain, Domenico De Berardis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Insomnia; Mental health; Physical health; perceived social support; Postpartum Depression

Online: 3 January 2023 (08:30:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0586.v1

Effects of Plant-Emitted Monoterpenes on Anxiety: A Propensity-Matched Observational Cohort Study

Davide Donelli, Francesco Meneguzzo, Michele Antonelli, Diego Ardissino, Giampaolo Niccoli, Giorgio Gronchi, Rita Baraldi, Luisa Neri, Federica Zabini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Anxiety; Biogenic volatile organic compounds; Forest therapy; Monoterpenes; α-Pinene; Propensity matching.

Online: 31 December 2022 (08:04:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0569.v1

A Scoping Review of Digital Wellbeing in Early Childhood: Definitions, Measurements, Contributors, and Interventions

Simin Cao, Hui Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: young children; early childhood; digital; wellbeing; review; definition; measurement; contributor; intervention.

Online: 30 December 2022 (04:29:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0445.v1

Examining Predictors of Psychological Well-being among University Students: A Descriptive Comparative Study across Two Samples

Wareerat Thanoi, Nopporn Vongsirimas, Yajai Sitthimongkol, Piyanee Klainin-Yobas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: stress; resilience; mindfulness; psychological well-being; university students

Online: 23 December 2022 (06:10:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0245.v1

Co-Use, Simultaneous Use, and Mixing of Cannabis and Tobacco: A Cross-national Comparison of Canada and the US by Cannabis Administration Type

Alanna Chu, Michael Chaiton, Pamela Kaufman, Renee Goodwin, Jodie Lin, Chandni Hindocha, Samantha Goodman, David Hammond

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cannabis; tobacco; co-use; simultaneous use; mixing

Online: 14 December 2022 (06:30:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0215.v1

Micronutrients in the Treatment of ADHD: Speculation or Opportunity?

Maurizio Coppola, Raffaella Mondola, Francesco Bevione

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; micronutrients; neurodevelopment; disattention; hyperactivity

Online: 13 December 2022 (01:58:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0149.v1

The Effects of Social Support on Depression and Vital Exhaustion during the COVID-19 Pandemic

Viktor Rekenyi, Szabolcs Garbóczy, Anita Szemán-Nagy, Ala’a B. Al-Tammemi, Mohamed Sayed-Ahmad, László Róbert Kolozsvári

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: international students, social support, depression, vital exhaustion

Online: 8 December 2022 (08:51:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0064.v1

Application of Natural Language Processing (NLP) in Detecting and Preventing Suicide Ideation: A Systematic Review

Abayomi Arowosegbe, Tope Oyelade

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Natural language processing; NLP; Text mining; Suicide; Suicide-Ideation; Mental Health

Online: 5 December 2022 (07:34:30 CET)

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Introduction: Around a million people are reported to die by suicide every year, and due to the stigma associated with the nature of the death, this figure is usually assumed to be an underestimate. Suicide may be prevented if prompt intervention is taken to mitigate risk. Machine learning and artificial intelligence-based modelling, such as natural language processing (NLP) and other text analytics approaches, has the potential to become a major technique for the detection, diagnosis, and treatment of people who are suffering from mental health issues. The primary aims of this research are to determine whether NLP techniques have been utilised in the field of suicide prevention, and if so, were they effective? What were their limitations? Methods: PubMed, EMBASE, MEDLINE, PsycInfo, and Global Health databases were searched for studies that reported use of NLP for suicide ideation or self-harm. Thematic analysis was used to synthesise and analyse the included studies. Findings were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement, and the Mixed Methods Appraisal Tool (MMAT) was used in assessing paper quality. Result: The preliminary search of five databases generated 387 results. Removal of duplicates resulted in 158 potentially suitable studies. Twenty papers were finally included in this review. Discussion: Studies show that combining structured and unstructured data in NLP data modelling yielded more accurate results than utilizing either alone. Also, to reduce suicides, people with mental problems must be continuously and passively monitored. Further, NLP and other machine learning/artificial intelligence technologies can be used to address health inequities and electronic health records provide valuable data for creating suicide risk tools. Finally, Online, social media, and smartphone applications can be leverage in detecting people with suicide ideation. Conclusion: The use of artificial intelligence and machine learning opens new avenues for considerably guiding risk prediction and advancing suicide prevention frameworks. The review's analysis of the included research revealed that the use of NLP may result in low-cost and effective alternatives to existing resource-intensive methods of suicide prevention. To summarise, there is substantial evidence that NLP is useful in identifying people who have suicide ideation.

Preprint ARTICLE | doi:10.20944/preprints202211.0555.v1

Assessment of Nutritional Status and Risk of Malnutrition Using Adapted Standard Tools in Patients with Mental Illness and in Need of Intensive Psychiatric Treatment

Ladina Risch, Florian Hotzy, Stefan Vetter, Sascha Hiller, Kathrin Wallimann, Erich Seifritz, Sonja Mötteli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: nutritional risk screening; severe mental illness; psychiatric treatment; BMI; nutritional status; malnutrition; depression; schizophrenia; nutrition; diet

Online: 30 November 2022 (02:44:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0549.v1

The Relationship between Ambient Fine Particulate Matter (PM2.5) Pollution and Depression: An Analysis of Data from 185 Countries

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: air pollution; PM2.5; depression; inflammation; ecological analysis; climate; gender

Online: 29 November 2022 (10:12:54 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202211.0407.v1

On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder

Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; autism spectrum disorder; autophagy; macrophage polarization; neurogenesis; taurine

Online: 22 November 2022 (05:46:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0341.v1

Effectiveness of a Woodworking Program on Psychosocial Health among Older Adults with Cognitive Impairment

Hyun-Joo Lee, Si-Woo Ban, Ha-Yun Chung, Myoung-Ok Jeon, Kye-Yean Kim, Ja-Eun Kim, Ki-Woung Lim, Chang-Ick Choi, Don-ha Choi, Ui-Do Hwang, Won-Chul Shin, Hye-Ri Shin, Young-Sun Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: woodworking program; MCI; mild dementia; psychological health; social health; older adults

Online: 17 November 2022 (16:13:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0303.v1

Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-derived Neurotrophic Factor

Nishtha Agnihotri, M. Hasan Mohajeri

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: gut-brain-axis; BDNF; bacteria; neuron; neurotrophin; hippocampus

Online: 16 November 2022 (09:54:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0269.v1

Occupational Stress and Burnout among Intensive Care Unit Nurses during the Pandemic: A Prospective Longitudinal Study of Nurses in COVID and non-COVID Units

Pratima Saravanan, Tariq Nisar, Qian Zhang, Faisal Masud, Farzan Sasangohar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: critical care; physiological measurement; nursing and nursing systems; naturalistic study; fatigue

Online: 15 November 2022 (03:18:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0258.v1

Deep Brain Stimulation in the Treatment of Tardive Dyskinesia

Adrianna Szczakowska, Agata Gabryelska, Oliwia Gawlik-Kotelnicka, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: tardive dyskinesia; schizophrenia; antipsychotics; deep brain stimulation

Online: 14 November 2022 (11:12:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0149.v1

How Functional Connectivity Measures Affect the Outcomes of MST Neuronal Network Characteristics in Patients with Schizophrenia Compared to Healthy Controls

Kamil Jonak, Magdalena Marchewka, Arkadiusz Podkowiński, Agata Siejka, Małgorzata Plechawska-Wójcik, Paweł Krukow

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: functional connectivity; schizophrenia; EEG; neuronal networks; PLI; PLV; MST

Online: 8 November 2022 (08:52:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0409.v1

Prevalence and Predictors of Anxiety Among Stable Hospitalized COVID-19 Patients in Malaysia

Muhammad Azri Adam Adnan, Mohd Shaiful Azlan Kassim, Hafizah Sahril, Mohamad Aznuddin Abd Razak

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; Anxiety; Mental Health; Hospitalized; Malaysia

Online: 26 October 2022 (09:55:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0327.v1

Antipsychotics in the Management of Disruptive Behavior Disorders in Children and Adolescents: An Update and Critical Review

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: disruptive behavior disorders; conduct disorder; oppositional defiant disorder; aggression; atypical antipsychotics; risperidone; clozapine

Online: 21 October 2022 (10:03:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0013.v1

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: selenium; oxidative stress; serotonin; glutamate; anxiety disorders; obsessive-compulsive disorders; post-traumatic stress disorder

Online: 3 October 2022 (15:17:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0453.v1

Anxiety and Depression of Cancer Patients: Phylosophical Review of Psychological Aspects

Lukman Prasetyo, Desi Rahayu, Moses Pandin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cancer; anxiety; depression

Online: 29 September 2022 (07:05:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0426.v1

Association Between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients

Sergej Nadalin, Sanja Dević Pavlić, Vjekoslav Peitl, Dalibor Karlović, Lena Zatkovic, Smiljana Ristić, Alena Buretić-Tomljanović, Hrvoje Jakovac

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: angiotensin-converting enzyme (ACE); antipsychotic medication; polymorphism, insertion/deletion; treatment response

Online: 28 September 2022 (03:12:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0400.v1

Prevalence of Physical Symptoms and Burnout Syndrome in Healthcare Professionals after One Year of Pandemic: Study #COVID 19PS

Jordi Esquirol Caussa, Manuel García San Emeterio, Marta Méndez Olavide, Vanessa Bayo Tallón, Josep Sánchez Aldeguer

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID 19; health personnel; Burnout, Psychological; COVID 19 stress syndrome

Online: 26 September 2022 (11:42:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0307.v1

Training on Emotional Intelligence for Caregivers of Patients with Acquired Brain Injury and Cognitive Impairment: A Quasi-Experimental Study

Irene De-Torres, Fernando Bustos, Juan Carlos Arango-Lasprilla, Pablo Fernández-Berrocal

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotional intelligence; brain injury; cognitive impairment

Online: 20 September 2022 (13:14:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0278.v1

Facebook and Suicidal Behaviour: User Experiences of Suicide Notes, Live-streaming, Grieving and Preventive Strategies. A Scoping Review.

Sheikh Shoib, Miyuru Chandradasa, Mahsa Nahidi, Tan Weiling Amanda, Sonia Khan, Fahimeh Saeed, Sarya Swed, Marianna Mazza, Marco Di Nicola, Giovanni Martinotti, Massimo Di Giannantonio, Aishatu Yusha’u Armiya’u, Domenico De Berardis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Suicide attempt; behaviour; prevention; Facebook

Online: 19 September 2022 (10:33:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0268.v1

Impact of COVID-19 Lockdowns on the Activity and Mental Health of Older People in Indonesia: A Qualitative Study

Nelsensius Klau Fauk, Ernawati Ernawati, Elsa Dent, Gregorius Abanit Asa, Paul Russell Ward

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 outbreak; lockdown protocols; individual and social activities; mental health challenges; older people; Indonesia

Online: 19 September 2022 (07:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0265.v1

‘I doubt myself and am losing everything I have since COVID came’- The Case Study of Mental Health and Coping Strategies among Undocumented Myanmar Migrant Workers in Thailand

Tual Sawn Khai, Muhammad Asaduzzaman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; migrant health; undocumented migrants; COVID-19; coping strategy; Myanmar; Thailand; mixed method

Online: 19 September 2022 (05:40:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0228.v1

Resting-State Functional Connectivity Impairment in Patients With the Major Depressive Episode

Drozdstoy Stoyanov, Vladimir Khorev, Rossitsa Paunova, Sevdalina Kandilarova, Denitsa Simeonova, Artem Badarin, Semen Kurkin, Alexander Hramov

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: functional connectivity; functional magnetic-resonance imaging; resting state; mood disorders; classification

Online: 15 September 2022 (09:20:26 CEST)

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Aim. In the current study, we aimed at identifying resting-state brain networks, which are different in patients with depression compared to healthy individuals. Moreover, we analyzed the potential for clinical use of different network measures that could discriminate the two groups and thus help the diagnostic process. Method and subjects. We recruited 90 subjects: 49 healthy controls (HC) and 41 patients with a major depressive episode (MDE). All subjects underwent clinical evaluation and functional resting-state MRI. The data were processed to investigate functional connectivity network measures across the two groups using Brain Connectivity Toolbox. The statistical inferences were made at the functional networks level, using false discovery rate method. Independent samples t-test was performed on the network measures mean values to reveal differences between HC and MDE groups. Permutation-based statistical testing was used to test the significance of the difference between the distributions of the network measures by nodes for HC and MDE groups. Linear discriminant analysis was used to differentiate between the groups. Results and discussion. Significant differences in FC between depressed patients and healthy controls were found with the most prominent changes encompassing within-region as well as between-region connectivity of occipital lobe areas such as precuneus (PreCu), cuneus (Cu), superior occipital gyrus (SOG), lingual gyrus (LG), fusiform gyrus (FG), cerebellum, along with limbic structures including the hippocampus (Hipp) and cingulate gyrus. Linear discriminant analysis demonstrated that the full connectivity matrices, as well as those with only the significant connections identified in advance, were the most precise in differentiating between depression and health. These measures reached precision levels of 97% and 94%, respectively. Conclusion. Our study delivered further evidence about impairment of functional connectivity networks in MDE that may contribute to differentiate patients with depression from healthy subjects.

Preprint ARTICLE | doi:10.20944/preprints202209.0213.v1

Interaction Between Participation and Impact of a Multicomponent Empowerment-based Psychosocial Mental Health Intervention on Service Users and Their Relatives

Francisco José Eiroa-Orosa, Maria Jesús San Pío, Gemma Marcet, Isabela Sibuet, Emilio Rojo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: community care; integrated care; mental health; service users and relatives’ interventions; service users and relatives’ interaction

Online: 14 September 2022 (16:27:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0121.v1

Effects of Cathinones (Bath Salts) On Cultured Primary Neurons/Astroglia Cells and Neurobehavioral Functions in Mice

Tyler M. Selig, Kevin Pierre, Rawad Daniel Arja, Abeer Dagra, Mark Gold, Vijaya Raghavan, Firas Kobeissy, Zhihui Yang, Kevin K. W. Wang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Cathinones; Designer drugs; Bath salts; Neuronal injury; astroglial injury; Calpain; Caspase

Online: 8 September 2022 (09:14:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0110.v1

The Link between ADHD and Antisocial Behavior: The Moderating Role of the Protective Factor Sense of Coherence

Haym Dayan, Mona Khoury-Kassabri, Yehuda Pollak

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Antisocial Behavior; Sense of Coherence; Protective Factors

Online: 7 September 2022 (11:03:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0069.v1

E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging

Morgan Ramón-Landreau, Cristina Sánchez-Puelles, Noelia López-Sánchez, Anna Lozano-Ureña, Aina M. Llabrés-Mas, José M. Frade

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: acetylated E2F4; synapsis; tissue homeostasis; Alzheimer’s disease; 5xFAD mice; neuroinflammation; microgliosis; reactive astrocytes.

Online: 5 September 2022 (13:52:27 CEST)

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E2F4 was initially described as a transcription factor with a key function in the regulation of cell quiescence. Nevertheless, a number of recent studies have established that E2F4 can also play a relevant role in cell and tissue homeostasis as well as tissue regeneration. For these non-canonical functions, E2F4 can also act in the cytoplasm, where it is able to interact with many homeostatic and synaptic regulators. Since E2F4 is expressed in the nervous system, it may fulfill a crucial role in brain function and homeostasis, being a promising multifactorial target for neurodegenerative diseases and brain aging. The regulation of E2F4 is complex as it can be chemically modified through acetylation, from which we present evidence in the brain, as well as methylation, and phosphorylation. The phosphorylation of E2F4 within a conserved threonine motif induces cell cycle re-entry in neurons, while a dominant negative form of E2F4 (E2F4DN), in which the conserved threonines have been substituted by alanines, has been shown to act as a multifactorial therapeutic agent for Alzheimer’s disease (AD). We have generated transgenic mice neuronally expressing E2F4DN. We have recently shown using this mouse strain that expression of E2F4DN in 5xFAD mice, a known murine model of AD, improved cognitive function, reduced neuronal tetraploidization, and induced a transcriptional program consistent with modulation of amyloid-beta (Abeta) peptide proteostasis and brain homeostasis recovery. 5xFAD/E2F4DN mice also showed reduced microgliosis and astrogliosis in both cerebral cortex and hippocampus at 3-6 months of age. Here we have analyzed the immune response in 1 year-old 5xFAD/E2F4DN mice, concluding that reduced microgliosis and astrogliosis is maintained at this late stage. In addition, the expression of E2F4DN also reduced age-associated microgliosis in wild-type mice, thus stressing its role as a brain homeostatic agent. We conclude that E2F4DN transgenic mice represent a promising tool for the evaluation of E2F4 as a therapeutic target in neuropathology and brain aging.

Preprint ARTICLE | doi:10.20944/preprints202208.0458.v1

Beyond the Penrose Hypothesis: Examining the Association between the Availability of Psychiatric Care and National Homicide Rates in 166 Countries

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental illness; homicide; violence; psychiatry; Penrose hypothesis; deinstitutionalization

Online: 26 August 2022 (10:00:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0391.v1

Workplace Assessment Scale: Pilot Validation Study

Eileen Huang, Nicole E. Edgar, Sarah E. MacLean, Simon Hatcher

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: scale design; reliability; validity; first responders; mental health; workplace; occupational stress; humiliation; betrayal

Online: 23 August 2022 (03:50:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0355.v1

A Comprehensive Study of De Novo Mutations on Protein-protein Interaction Interface Provides New Insights in Developmental Delay

Dhruba Tara Maharjan, Weichen Song, Zhe Liu, Weidi Wang, Wenxiang Cai, Jue Chen, Fei Xu, Weihai Ying, Guan Ning Lin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: developmental delay; de novo mutation; protein-protein interaction; PPI interface; protein in-teractome; PsymuKB

Online: 19 August 2022 (04:50:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0344.v1

The Mental Health of Young Return Migrants with Ancestral Roots in Their Destination Country: A Cross-Sectional Study Focusing on the Ethnic Identities of Japanese-Brazilian High School Students Living in Japan

Eriko Fukui, Takashi Uchino, Masunari Onozaka, Takashi Kawashimo, Momoko Iwai, Youji Takubo, Akiko Maruyama, Sachio Miura, Ryo Sekizaki, Masafumi Mizuno, Naoyuki Katagiri, Naohisa Tsujino, Takahiro Nemoto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ethnic identity; mental health; migrant; transcultural psychiatry; youth

Online: 18 August 2022 (10:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0341.v1

An Integrative Analysis Identified Schizophrenia-Associated Brain Cell Types and Gene Expression Changes

Wenxiang Cai, Weichen Song, Zhe Liu, Dhruba Tara Maharjan, Jisheng Liang, Guan Ning Lin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; cell types proportions; differential expression genes; functional pathways; CIBERSORTx

Online: 18 August 2022 (10:54:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0297.v1

The Impact of Foehn Wind on Mental Distress among Patients in a Swiss Psychiatric Hospital

Christian A. Mikutta, Charlotte Pervilhac, Hansjörg Znoj, Andrea Federspiel, Thomas J Müller

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: foehn wind; psychopathology; BSCL; mental health; weather; meteorological factors; climate change

Online: 17 August 2022 (04:04:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0276.v1

Determinants of Mental Health during and after COVID-19 Lockdown among University Students in Malaysia

Shang Kuan Ng, Imtiyaz Ali Mir, Muhammad Noh Zulfikri Mohd Jamali, Mohammed AbdulRazzaq Jabbar, Syeda Humayra

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 lockdown; anxiety; depression; family income; physical activity

Online: 16 August 2022 (03:59:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0262.v1

A Narrative Inquiry into the Practices of Healthcare Workers Wellness Program: The SEED Experience in New South Wales, Australia

Katarzyna Olcon, Julaine Allan, Mim Fox, Ruth Everingham, Padmini Pai, Lynne Keevers, Maria Mackay, Chris Degeling, Sue-anne Cutmore, Summer Finlay, Kristine Falzon

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: healthcare workers; workplace wellness; mental health and wellbeing; recovery; resilience; Australian bushfires; COVID-19; burnout; occupational trauma

Online: 15 August 2022 (11:58:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0227.v1

Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study

Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Mayumi Kataoka, Daisuke Nishi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; depression; anxiety; post-acute COVID-19 syndrome; post-COVID

Online: 12 August 2022 (04:56:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0180.v1

A Systematic Review of Recreational Nitrous Oxide Use: Implications for Policy, Service Delivery and Individuals

Julaine Allan, Jacqui Cameron, Juliana Bruno

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Nitrous Oxid; N₂O; nangs; systematic review; harm reduction; drug use

Online: 9 August 2022 (11:29:40 CEST)

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Background Nitrous Oxide (N₂O) is a dissociative anaesthetic that is sometimes used recreationally. The prevalence of N₂O use is difficult to quantify but appears to be increasing. Research on N₂O harms and application of harm reduction strategies are limited. The aim of this mixed method systematic review was to collate and synthesise the disparate body of research on recreational nitrous oxide use to inform harm reduction approaches tailored for young people. Methods To identify publications reporting recreational use of N₂O, a search of public health, psychology and social science databases was conducted. Databases included PubMed, CIHNAL, PsycINFO, Scopus and Web of Science. Gray literature and Google advanced search were also used. Due to limited published literature on the recreational use of N₂O, no limit was placed on publication date or study type. A thematic synthesis extracted descriptive and analytical themes from the selected studies. Quality appraisal was conducted using the CASP Tool for Qualitative studies and the Joanna Briggs Institute case report assessment tool Results The search retrieved 407 reports. Thirty-four were included in the final analysis including sixteen case reports. The included studies were primarily concerned with raising awareness of the apparently increasing use and subsequently increasing harms of recreational N₂O use. There was limited reference to policy or legislative responses in any published studies, no suggestions for harm reduction strategies or application of service level responses. In general, individuals lack awareness of N2O related harms. Conclusion The review found three key areas that deserve further consideration including: 1) policy, 2) service delivery, and 3) harm associated with N₂O use. We recommend a top-down (policy) and bottom-up (services delivery/services users) approach to harm reduction for N₂O use which also includes further consultation and research with both groups. Future research could explore young people’s experience of N₂O use including benefits and problems to inform contextually relevant harm reduction strategies.

Preprint ARTICLE | doi:10.20944/preprints202208.0178.v1

A Genome-Wide Association Study Reveals New Genes in a Molecular Network Associated With Alcohol Dependence and Related Clinical Measures

Anastasia Levchenko, Sergey Malov, Alexey Antonik, Anastasia Protsvetkina, Kseniya V. Rybakova, Alexander Kanapin, Alexey N. Yakovlev, Anna Y. Nenasteva, Anton E. Nikolishin, Nikolay Cherkasov, Natalia A. Chuprova, Anna S. Blagonravova, Angelica V. Sergeeva, Tatyana V. Zhilyaeva, Maria K. Denisenko, Raul R. Gainetdinov, Alexander O. Kibitov, And Evgeny M. Krupitsky

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol dependence; comorbidity; gene network; genome-wide association study; sex differences

Online: 9 August 2022 (10:35:29 CEST)

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Preprint ESSAY | doi:10.20944/preprints202208.0037.v1

“Deep Sleep”: A Comparative Approach to Defining Meaningful Rest

Matt Gaidica

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deep sleep; slow-wave activity; evolution; comparative; physiology; homeostasis

Online: 2 August 2022 (04:46:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0007.v1

Mental Wellbeing and Social Resilience of Eritrean Refugees living in Germany

Temesghen Gebresilassie, Claudia Beiersmann, Sandra Ziegler, Verena Keck, Yonas Semere Kidane, Albrecht Jahn, Janine Benson-Martin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Eritrean refugees; mental wellbeing; social resilience; Germany; ADAPT model

Online: 1 August 2022 (05:27:03 CEST)

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Mental health and social resilience play a significant role in refugees’ adaptation during the resettlement process in the host country. Maintaining good mental wellbeing helps the refugees to respond to stressful experiences with healthy life choices. This study aimed to explore the mental wellbeing and social resilience of Eritrean refugees living in Germany and to identify social conditions and enablers to foster adaptation. This study employs a qualitative approach with a semi-structured, in-depth interview data collection method. Informants were identified among mostly young adult refugees living in Heidelberg, Germany, with a migration history of 3-6 years. In total, 15 informants were recruited through snowball sampling. Data were sorted and analyzed using the five pillars of the Adaptation and Development after Persecution and Trauma (ADAPT) model. The findings suggest that Eritrean refugees experience psychological distress after resettlement in Germany, however with time, their mental health has improved. The study revealed conditions that were experienced as hindrances, as well as ones that were considered to be resources of positive mental wellbeing and social resilience for resettled refugees. Challenges described were the language barrier, discrimination, unemployment, insecure residence status, loss of family and friends, conflict within the diaspora community, and isolation. The main sources of mental wellbeing and social resilience include the feeling of being welcomed by local communities, access to social services, adopting new relationships, and educational opportunities. These experiences encouraged refugees to have a favorable view of their lives and futures as well as also found to facilitate better integration and adaptation. Understanding refugee mental wellbeing and social resilience require a multidimensional perspective. Eritrean refugees living in Germany have experienced and still are experiencing resettlement challenges, as for example loss of family and friends, negative perception of the German system, loss of past achievements, or unemployment. But they have developed adaptive and resilience mechanisms, too, such as seeing an opportunity for a better life, adopting new roles, and accepting Germany as a “second home”. In addressing those by the refugees as hindrances reported issues, these could be turned into sources of mental well-being and resilience.

Preprint ESSAY | doi:10.20944/preprints202207.0303.v1

Behavioral Activation (BA) as an Intervention for Depressed Adolescents

Joshua Sanchez

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; adolescents; behavioral activation

Online: 20 July 2022 (11:48:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0219.v1

Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized Psychiatry

Alessandra Alciati, Angelo Reggiani, Daniela Caldirola, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: personalized psychiatry; psychiatric disorders; induced pluripotent stem cells; brain organoids

Online: 14 July 2022 (11:46:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0151.v1

Psychological Distress in South African Healthcare Workers early in the COVID-19 Pandemic: An Analysis of Associations and Mitigating Factors

Hsin-Ling Lee, Kerry Wilson, Colleen Bernstein, Nisha Naicker, Annalee Yassi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychological distress; COVID-19 pandemic; health care workers; perceived risks; workplace relationship; support; training; workplace hazards; perceived barriers; job tension

Online: 11 July 2022 (07:40:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0130.v1

Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan-Kynurenine Metabolic System

Masaru Tanaka, Ágnes Szabó, Eleonóra Spekker, Helga Polyák, Fanni Tóth, And László Vécsei

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Keywords: mitochondria; stress resilience; plasticity; stress; kynurenine; Alzheimer’s disease; neurodegenerative; depression; anxiety; psychiatric

Online: 8 July 2022 (03:56:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0079.v1

Immersive Therapy for Improving Anxiety in Health Professionals of a Regional Hospital During the COVID-19 Pandemic: A Quasi-Experimental Pilot Study

Marta Linares-Chamorro, Neus Domènech-Oller, Javier Jerez-Roig, Joel Piqué-Buisan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Virtual reality; health professionals; anxiety; immersive therapy

Online: 5 July 2022 (16:01:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0064.v1

Pharmacotherapy for the Secondary Prevention of Suicide: Leads from the Social Pain Hypothesis

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; social pain; psychache; endogenous opioid system; oxytocin; serotonin; endocannabinoids; buprenorphine; psilocybin; ketamine

Online: 5 July 2022 (07:43:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0395.v1

Effectiveness of Agreement Criteria and Flows of Collaborative Care in Primary Mental Health Care in Brazil

Valdecir Carneiro da Silva, Ardigleusa Alves Coelho, Ana Angélica Rêgo de Queiroz, Gabriela Maria Cavalcanti Costa, João Carlos Alchieri, Ricardo Alexandre Arcêncio, Severina Alice da Costa Uchôa

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mental Health; Primary Health Care; Collaborative Care; Health Assessment

Online: 29 June 2022 (05:05:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0327.v1

Strengthening the Role of Peer Counselors for Reproductive Health among Adolescent: From Philosophy into Practice

Ririn Harini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescent; health reproductive; peer counselor

Online: 24 June 2022 (02:52:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0296.v1

Storyboarding HIV Infected Young People’s Adherence to Antiretroviral Therapy in Lower to Upper Middle-Income Countries: A New-Materialist Qualitative Evidence Synthesis

Lynn A Hendricks, Taryn Young, Susan Van Wyk, Catharina Matheï, Karin Hannes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: new materialism; assemblage; storyboarding; HIV; adherence; antiretroviral therapy; young people; perinatal infection; qualitative evidence synthesis; biopsychosocial

Online: 21 June 2022 (10:54:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0004.v1

The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: a Systematic Review and Meta-Analysis

Sarah Houben, Bruno Bonnechère

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Long-COVID; cognitive disorders; rehabilitation

Online: 1 June 2022 (05:50:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0413.v1

Routine Use of Financial Capacity Instruments for Clinical Decisional Capacity Testing: A Scoping Review

Eduard P. Drima

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: financial capacity instruments; Semi-Structured Clinical Interview for Financial Capacity; deci-sional capacity; mild cognitive impairment; gamification

Online: 31 May 2022 (07:37:21 CEST)

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Financial capacity instruments are psychometric tools designed to evaluate individual decisional capacity based on financial decisions. As tests are complex and need special conditions for administration and evaluation, it is difficult to use them in daily geriatric clinics. Our scoping review objective was to evaluate existing financial capacity instruments from the perspective of simplicity and portability. We evaluated one English speaking knowledge database (Medline) using a dedicated MeSH terminology. The review yielded one independent instrument, The Semi-Structured Clinical Interview for Financial Capacity, that can be easy adapted for every-day clinical use. It is simple to understand and perform and do not need trained personnel for administration. It can be finalized in 15 minutes. Initially validated on 261 subjects (with different forms of cognitive impairment), it showed good accuracy and precision mainly in subjects with cognitive impairment. The test is less apt to detect early or fluctuating cognitive impairment. Simplicity, the main advantage of the test, allows gamification fact that increases portability. Familiar images (coins, money) that are used for performing simple tasks does not need complex translation and adaptation. In form of a game, the test is suitable for serial administration, increasing the chance for early capacity reduction detection. Results reflect a physician judgement related to the subjects’ capacity to understand and execute simple financial instructions and not financial proficiency scores. The main limitation of our review is that we investigated only one, English speaking, knowledge database. The scoping strategy generated a financial capacity instrument that can be used in geriatric clinics for early diagnostic of decisional capacity reduction. Further studies are needed to evaluate the reliability and validity of the test in conditions of serial administration and in populations having various financial experience.

Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0291.v2

Reductions in Anxiety, Depression and Insomnia in Health Care Workers Using a Non-pharmaceutical Intervention

Katherine Currie B.S., Babu V. Gupta, Ishan Shivanand, Amit Desai, Shweta Bhatt, Hari S. Tunuguntla, Sadhna Verma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Yoga of Immortals (YOI); depression; healthcare workers; insomnia; anxiety; PHQ-8 (Pa-tient Health Questionnaire-8); ISI (Insomnia Severity Index); digital health

Online: 24 May 2022 (04:49:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0291.v1

Reductions in Anxiety, Depression and Insomnia in Health Care Workers using a non-pharmaceutical intervention

Katherine Currie B.S., Babu V. Gupta, Ishan Shivanand, Amit Desai, Shweta Bhatt, Hari S. Tunuguntla, Sadhna Verma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Yoga of Immortals (YOI); depression, healthcare workers; insomnia; anxiety; PHQ-8 (Pa-tient Health Questionnaire-8); ISI (Insomnia Severity Index); digital health

Online: 23 May 2022 (10:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0160.v1

Analysis of Phenolic Compounds in Parkinson’s Disease: A Bibliometric Assessment of the 100 Most Cited Papers

José Messias Perdigão, Bruno José Brito Teixeira, Daiane Claydes Baia-da-Silva, Priscila Cunha Nascimento, Rafael Rodrigues Lima, Hervé Rogez

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Bibliometric; Parkinson’s Disease; Phenolic compound

Online: 12 May 2022 (07:58:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0144.v1

Predicting Remission among Perinatal Women with Depression in Rural Pakistan: A Prognostic Model for Task-Shared Interventions in Primary Care Settings

Ahmed Waqas, Siham Sikander, Abid Malik, Najia Atif, Eirini Karyotaki, Atif Rahman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Perinatal depression; prognosis; prognostic modeling; nomogram; Pakistan

Online: 10 May 2022 (15:40:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0201.v1

Compliance with Standard Precaution and Its Relationship With Views on Infection Control and Prevention Policy Among Chinese University Students During the COVID-19 Pandemic

Winnie Cheng, Enid Kwong, Regina Lee, Anson Tang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; emotion-focused coping; infection control practices; perceived stress; relation-ship-focused coping

Online: 21 April 2022 (10:06:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0121.v1

Discrepancy between Desired Time in Bed and Desired Total Sleep Time in Patients with Cancer: The DBST Index and the Relationship with Insomnia Severity or Sleep Onset Latency

Eulah Cho, Jaeeun Song, Joohee Lee, Inn-Kyu Cho, Dongin Lee, Hayun Choi, Harin Kim, Seockhoon Chung

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cancer; insomnia; sleep; circadian; the DBST index

Online: 13 April 2022 (08:36:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0327.v1

Memory Enhancement with Kynurenic Acid and its Mechanisms in Neurotransmission

Diána Martos, Bernadett Tuka, Masaru Tanaka, László Vécsei, Gyula Telegdy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: tryptophan; kynurenine; kynurenic acid; passive avoidance; cognitive domain; memory; cognitive enhancer; neurotransmission; receptor blockers; translational

Online: 24 March 2022 (08:57:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0279.v1

The Pathways to Participation (P2P) Program: A Pilot Outcomes Study

Danielle Hitch, Lindsay Vernon, Rachel Collins, Carolyn Dun, Sarah Palexas, Kate Lhuede

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: recovery; mental illness; mental health; psychiatry; social inclusion; occupational therapy; occupations; time use; activities of daily living; work.

Online: 21 March 2022 (08:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0257.v1

Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice

Paul E. Rapp, Christopher Cellucci, David Darmon, David Keyser

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: biomarkers; electroencephalography; event related potentials; heart rate variability; diagnosis; sensitivity; specificity

Online: 17 March 2022 (15:19:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0191.v1

Alcohol Consumption, Loneliness, Quality of Life, Social Media Usage, and General Anxiety Before and During the COVID-19 Pandemic in Singapore

Mengieng Ung, Kalista Yearn Yee Wan, Shi Yu Liu, Ying Jie Choo, Nathaniel Shan Wei Liew, Zhexuan Azure Shang, Sophie Su Hui Khoo, Wei Xuan Tay, Ruixi Lin, Siyan Yi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; pandemic; GAD-7; mental health; quality of life; Asia

Online: 14 March 2022 (16:20:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0099.v1

Use of Long-Acting Injectable Antipsychotics in Inpatients with Schizophrenia Spectrum Disorder in an Academic Psychiatric Hospital in Switzerland

Stephan Reymann, Georgios Schoretsanitis, Stephan T. Egger, Alexey Mohonko, Matthias Kirschner, Stefan Vetter, Philipp Homan, Erich Seifritz, Achim Burrer

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: long-acting injectable; antipsychotic; depot; schizophrenia spectrum disorder; schizophrenia; schizoaffective; inpatient; prescribing pattern

Online: 7 March 2022 (12:33:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0156.v2

Ketamine as a Novel Psychopharmacotherapy for Eating Disorders: Evidence and Future Directions

Anya Ragnhildstveit, Matthew Slayton, Laura Jackson, Madeline Brendle, Sachin Ahuja, Willis Holle, Claire Moore, Kellie Sollars, Paul Seli, Reid Robison

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: esketamine; ketamine; ketamine assisted psychotherapy; eating disorder; anorexia nervosa; bulimia nervosa; binge eating disorder; pharmacology; psychedelics; treatment

Online: 7 March 2022 (08:34:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0062.v1

Sickness Behaviour and Depression: An Updated Model of Peripheral-Central Immunity Interactions

Federico Turkheimer, Mattia Veronese, Valeria Mondelli, Diana Cash, Carmine Pariante

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Major depression; inflammation; sickness behaviour; mechanism; model; microglia; zcitokynes; CRP; blood brain barrier; choroid plexus

Online: 3 March 2022 (10:28:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0285.v1

Bullied Because of Their Teeth: Evidence from a Longitudinal Study on the Impact of Oral Health on Bullying Victimization Among Australian Indigenous Children

Md Irteja Islam, Verity Chadwick, Tuguy Esgin, Alexandra Martiniuk

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Bullying; Oral health; Indigenous; Children; Australia

Online: 23 February 2022 (05:26:35 CET)

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Medicine and Pharmacology