Search Subject Areas | Preprints.org

Preprint CASE REPORT | doi:10.20944/preprints202404.0825.v1

Iron Supplementation in the Treatment of Cocaine Use Disorder

Sarah Hughes, Olivia Hill, Raja Mogallapu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Iron Deficiency, Cocaine, Substance Use Disorder

Online: 12 April 2024 (13:33:57 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0852.v1

Ginkgo biloba: A Leaf of Hope in the Fight Against Alzheimer’s Dementia: Clinical Trial Systematic Review

Guilherme Lopes de Oliveira Pagotto, Livia Maria Oliveira dos Santos, Najwa Osman, Caroline Barbalho Lamas, Lucas Fornari Laurindo, Karina Torres Pomini, Leila M. Guissoni, Enzo Pereira de Lima, Ricardo de Alvares Goulart, Virginia M. C. Strozze Catharin, Rosa Direito, Masaru Tanaka, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer disease; cognitive dysfunction; Gingko biloba; EGb 761; terpenoids; flavonoids

Online: 12 April 2024 (12:37:58 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0379.v1

Fatigue Syndrome (FS) Prevalence among Saudi Medical Students and Its Association with Depressive and Anxious Symptoms

Abdulmajeed A. Alkhamees, Lamees A. AlGubllan, Ahmad H. Alwashmi, Deem T. Alamr, Aeshah M. Alharbi, Norah A. Alturaif

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Keywords: Fatigue, Depression, Anxiety, Disease Association, Prevalence, Cross-sectional studies, Young Adult, Disease Severity.

Online: 4 April 2024 (17:44:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0294.v1

The Effect of a Cognitive Dual Task on Gait Parameters among Healthy Young Adults with Good and Poor Sleep Quality: A Cross-Sectional Analysis

Jood Dalbah, Shima A. Mohammad Zadeh, Meeyoung Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep quality; dual task; gait; velocity; cadence; stride length; step width

Online: 3 April 2024 (12:57:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0274.v1

Pre-pandemic Predictivity of Anxious-Depressive Symptoms in Post-surgical Traumatic Distress in Hysterectomy for Benign Disease and COVID-19 Outbreak: A Case-Control Study

Marta Ielmini, Jvan Casarin, Camilla Callegari, Alessandro Bellini, Manuela Giada Favata, Anna Giudici, Fabio Ghezzi, Antonella Cromi, Ivano Caselli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: post-traumatic stress disorder; post-surgical traumatic distress; anxiety; depression; hysterecto-my; COVID-19

Online: 3 April 2024 (10:35:06 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0105.v1

Epigenetic and Coping Mechanisms of Stress in Affective Disorders: a Scoping Review

Brenda-Cristiana Bernad, Mirela-Cleopatra Tomescu, Anghel Teodora, Diana Lungeanu, Virgil Enătescu, Elena Silvia Bernad, Vlad Nicoraș, Diana-Aurora Arnautu, Lavinia Hogea

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: epigenetic; coping; stress; affective disorders; DNA methylation; childhood trauma; stressor; depressive disorder; dietary deficiencies

Online: 1 April 2024 (14:54:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1543.v1

The Ripple Effect: Quality of Life and Mental Health of Parents of children with ADHD in Saudi Arabia a Cross-Sectional Study

Shuliweeh Alenezi, Samah H Alkhawashki, Muneera AlKhorayef, Sarah Alarifi, Shahad Alsahil, Renad AlHaqbani, Nouf Alhussaini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; parents; mental health; parenting challenges

Online: 26 March 2024 (11:52:42 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1482.v1

Treatment of Aggressive Behavior and Agitation in a 11-Year-Old Boy With Co-occurring Autism and ADHD: A Case Report and Literature Review on the Use of Intravenous Valproate in Emergency Psychiatry

Alessandra Carta, Vanna Cavassa, Mariangela V. Puci, Roberto Averna, Giovanni Sotgiu, Giovanni Valeri, Stefano Vicari, Stefano Sotgiu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism; ADHD; agitation; intravenous valproate.

Online: 26 March 2024 (08:20:54 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1480.v1

Implementing an Early Detection Program for Autism Spectrum Disorders in Polish Primary Healthcare Setting – Possible Obstacles and Experiences from Online ASD Screening

Mateusz Sobieski, Urszula Grata-Borkowska, Maria Magdalena Bujnowska-Fedak

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: autism spectrum disorders; population screening; autism screening; online screening

Online: 25 March 2024 (11:18:48 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1410.v1

The Outcome of the Psychological and Therapeutical Care of Hospitalized COVID-19 Patients: National African Pilot Study

Yassine BENHADDOUCH, Nour ELhouda Fares, Soumaya BENMAAMAR, Youssef OUAZZANI HOUSNI TOUHAMI, Amine BOUT, Chadya AARAB, Said BOUJRAF, Rachid AALOUANE

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Anxiety; depression; post-traumatic stress; hydroxychloroquine; family support; intensive care

Online: 25 March 2024 (08:08:12 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1124.v1

A Unifying Hypothesis for the Genome Dynamics Proposed to Underly Neuropsychiatric Phenotypes

George Sebastian Gericke

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: common fragile sites; stress; mobile elements; immune; RAG 1/2; genome plasticity; neuropsychiatric; GWAS; epigenetic

Online: 22 March 2024 (07:46:57 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1267.v1

A Female-Specific Treatment Group for ADHD – Description of the Programme and Qualitative Analysis of First Experiences

Maxime de Jong, Dora S.R.M. Wynchank, Marieke Michielsen, Aartjan T.F. Beekman, Sandra J.J. Kooij

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: attention deficit/hyperactivity disorder (ADHD); women; menstrual cycle; non-pharmacological treatment; group treatment; sex hormones; premenstrual; female specific therapy; self-awareness; self-acceptance

Online: 21 March 2024 (11:26:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0951.v1

Sociodemographic and Clinical Correlates including Psychiatric Comorbidities in Clinical Population of Irritable Bowel Syndrome

Ankita Saroj, Adarsh Tripathi, Sumit Rungta, Sujita Kumar Kar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Irritable bowel Syndrome; Psychiatric comorbidities; Somatic symptoms; Anxiety; Stress

Online: 18 March 2024 (09:20:22 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0605.v1

Understanding Spontaneous Symbolism in Psychotherapy Using Embodied Thought

Erik D Goodwyn

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Embodied Metaphor; Depth Psychology; Cognitive Neuroscience; Affective Neuroscience; Psychobiology; Hypnotherapy; Evolutionary Biology; Code Biology

Online: 11 March 2024 (13:05:20 CET)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202403.0594.v1

From CBT to Complex Therapy: A Novel Approach to the Treatment of Mental Disorders

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Complex Therapy; Psychiatry; Psychotehrapy; CBT; MindLAB Set; NegEnt

Online: 11 March 2024 (10:29:07 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0551.v1

Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre-post Intervention Study

Amelia McGuinness, Martin O'Hely, Douglas Stupart, David Watters, Samantha Dawson, Christopher Hair, Michael Berk, Mohammadreza Mohebbi, Amy Loughman, Glenn Guest, Felice Jacka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Gut microbiota; colonoscopy; bowel preparation; depression; microbiota-gut-brain axis; mental health; psychiatry; gastroenterology. ;

Online: 11 March 2024 (09:45:31 CET)

Show abstract| Download PDF| Supplementary Files| Share

Objective: Mechanical bowel preparation is essential for the visualisation of the colon during colonoscopy, and previous studies have identified changes in gut microbiota composition after bowel preparation and colonoscopy. Considering the gut microbiota is increasingly implicated in mood, we aimed to explore the potential impact of this intervention on mood and the microbiota-gut-brain axis. Methods: We conducted a pre-post intervention study, with timepoints of one week before and one month after bowel preparation and colonoscopy, in community-dwelling adults referred for colonoscopy. Our primary outcome was change in average Hospital Anxiety and Depression Scale depression sub-scores using generalised estimating equations. We also examined changes in average anxiety, stress, and quality of life scores, and faecal microbiota composition and potential function using 16S rRNA sequencing. We further explored associations between changes in depressive symptoms and the gut microbiota and conducted post-hoc analyses to explore potential effect modifiers. Key Results: 59 participants were included in the analyses. Depressive symptoms decreased one-month post-procedure compared to baseline (adjusted β=−0.64; 95%CI: −1.18, −0.11). Irritable bowel syndrome (IBS) appeared to moderate this relationship (1.78; 0.292, 3.26); depressive symptoms increased in those with, and decreased in those without, IBS. Changes in gut microbiome composition included reduced alpha diversity, modest effects on beta-diversity, and increases in genera associated with potential health benefits, one-month post-procedure compared to baseline. Increases in the CLR-transformed abundance of Ruminococcaceae UCG-009 were associated with improvements in depressive symptoms. Conclusions: There is preliminary evidence of a potential mental health effect of bowel preparation and colonoscopy, which may be associated with changes to the gut microbiota. There may also be a differential mental health impact of this procedure for those with and without IBS. Considering the limitations of our study, further research is required to confirm these findings and their clinical relevance.

Preprint ARTICLE | doi:10.20944/preprints202403.0477.v1

Body Awareness as a Protective Factor against Suicidal Orientations in College Students

Olga Lucía Montoya-Hurtado, Renato Sobral Monteiro-Junior, Cyndi Yacira Meneses-Castaño, Consuelo Sancho Sanchez, Antonio Martínez-Sabater, Maria Pilar Andrés-Olivera, Pilar Sánchez-Conde, Jesús Pérez, José Maria Criado-Gutierrez, Laura Criado-Pérez, Juan Luis Sanchez-González, Raúl Juárez-Vela

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: body awareness; interoception; suicide prevention; attempted suicide

Online: 8 March 2024 (11:18:48 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0516.v1

Aspects of Clinical Neuropsychology Related to the Psychotic Spectrum. A Comprehensive Systematic Review

Evgenia Gkintoni, Maria Skokou, Philippos Gourzis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Neuropsychology; Psychotic Spectrum; Neurobiological Pattern; Childhood Trauma; Dementia

Online: 8 March 2024 (10:35:52 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0259.v1

From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders

Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychosis; Parkinson's disease; antioxidants; genetic therapy; stroke; anxiety; migraine; epilepsy; aphasia; cardiovascular diseases; cognition

Online: 5 March 2024 (12:31:24 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0070.v1

Aggressiveness in Italian Children with ADHD: Maoa Gene Polymorphisms Involvement

Ludovico Neri, Beatrice Marziani, Pierluigi Sebastiani, Tiziana Del Beato, Alessia Colanardi, Maria Pia Legge, Anna Aureli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Aggressive behavior; MAOA; 5-HTT.

Online: 4 March 2024 (01:25:49 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0043.v1

Symptom Severity Changes in Obsessive-Compulsive Patients during COVID-19 Pandemic Are Associated with Shorter Illness Duration and Benzodiazepine Use: Possible Evolutionary Advantage of a Psychiatric Disorder

Giordano D’Urso, Alfonso Magliacano, Marco Manzo, Mattia Vittorio Pomes, Carla Iuliano, Felice Iasevoli, Bernardo Dell'Osso, Andrea De Bartolomeis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: obsessive-compulsive disorder; COVID-19; clinical evolution; adaptive psychopathology; illness duration; anxious diathesis

Online: 1 March 2024 (17:40:36 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1680.v1

The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China

Ke Ma, Tianhang Zhou, Chengcheng Pu, Zhang Cheng, Xue Han, Lei Yang, Xin Yu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; weight gain; cognitive function; first episode; China

Online: 29 February 2024 (09:51:16 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1447.v1

Cognitive Profiles of Partial PTSD in Vietnam War Veterans

Jihye Song, Hyung Seok So, Jin Hee Choi, Hayun Choi, Seung-Hoon Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: posttraumatic stress disorder; psychological Trauma; cognitive function; neurocognitive tests; veteran health

Online: 26 February 2024 (12:42:06 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1424.v1

Social Inhibition and Depressive symptoms among Couples Having Children with Autism Spectrum Disorder: The Mediating Role of Perceived Family Support

Ting Pan, Tinakon Wongpakaran, Nahathai Wongpakaran, Bijing He, Danny Wedding

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: social inhibition; autism; depression; family support; parents; actor partner interdependence mediation model

Online: 26 February 2024 (10:26:06 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1337.v1

Ana Pjevac, Teodora Safiye, Mirjana Jovanovic

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: internet addiction, adolescents, temperament, online, IAT, TEMPS

Online: 23 February 2024 (09:10:09 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202402.1273.v1

Above the Sea of Fog: Dietary and Lifestyle Interventions for the Treatment of Depression

Matthew Halma, Christof Plothe, Paul E Marik

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Major Depression; Lifestyle Medicine; Dietary approaches; Antidepressants

Online: 23 February 2024 (01:56:37 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0962.v1

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Which Differences between Alcohol, Cannabis and Psychostimulants?

Martina Di Paolo, Antonia Calabrese, Guido Nosari, Valentina Ciappolino, Luisa Cirella, Alice Caldiroli, Enrico Capuzzi, Massimo Clerici, Massimiliano Buoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol; cannabis; clinical variables; peripheral biomarkers; psychostimulants; substance-induced psychotic disorder

Online: 19 February 2024 (14:34:50 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0879.v1

Neurodegeneration in Cognitive Impairment and Mood Dis-orders for Experimental, Clinical and Translational Neuropsy-chiatry

Simone Battaglia, Alessio Avenanti, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’ s disease;
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity

Online: 16 February 2024 (05:40:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0762.v1

Mood Disorders and Sleep Quality among Undergraduate Students during Covid-19

Mariam Gogichadze, Nnaemeka Emmanuel Mgbedo, Irvin Savio Joao, Chinyere Victory Chukwu, Roshan Afreen Mohammad, Inga Odzelashvili, Natia Landia

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Depression; Anxiety; Stress; Sleep quality; Students; Covid19

Online: 14 February 2024 (08:18:32 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint SHORT NOTE | doi:10.20944/preprints202312.1904.v2

Living on the Edge: Navigating the Complex Landscape of Borderline Personality Disorder

Sharif Mohammed Sadat, Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Borderline personality Disorder; instability; Impulsive; Stigma; Psychiatry
;

Online: 12 February 2024 (11:08:01 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0601.v1

Influence of Social Media Usage, Academic Performance and Working Memory among Undergraduate Students

Nnaemeka Emmanuel Mgbedo, Marbyen Elma Musa, Pragati Chhikara, Rupam Chaturvedi, Nikita Vyas, Nana Zavradashvili

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: social media; academic performance; working memory; students; addiction

Online: 9 February 2024 (15:59:48 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202402.0429.v1

Treatments for Cannabis Use Disorder Across the Lifespan: A Systematic Review

Mohammad Ghafouri, Sabrina Correa da Costa, Ali Zaredehnavi, Mark S Gold, Teresa A Rummans

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Cannabis Use Disorder; CUD; psychotropic medications; behavioral interventions; substance use disorder

Online: 7 February 2024 (12:10:32 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0206.v1

Borderline Personality Disorder (BPD), A Narrative Review with Focus on BPD Comorbidities

JOSEPH SADEK

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Borderline personality disorder; Comorbidity; epidemiology; prevalence; diagnosis; Management

Online: 5 February 2024 (03:43:47 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0099.v1

Pathogenic Beliefs among Patients with Personality Disorders

Varit Jintanachote, Tinakon Wongpakaran, Nahathai Wongpakaran

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Pathogenic beliefs; Personality disorder; Control Mastery Therapy

Online: 2 February 2024 (10:27:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.1849.v2

Epidemiology of Suicide Mortality in Paraguay from 2005 to 2019: A Descriptive Study

Ethel Santacruz, Derlis Duarte-Zoilan, Gilda Benitez Rolandi, Felicia Canete, Dins Smits, Noel Christopher Barengo, Guillermo Sequera

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Suicide; trends; mental health; Paraguay; potential years of life lost

Online: 1 February 2024 (13:52:49 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202401.2002.v1

Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review

Anees Bahji

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: comorbidity; substance use disorders; psychiatric disorders; treatment interventions; dual diagnosis

Online: 29 January 2024 (12:52:26 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202401.1713.v1

Third-Generation Antipsychotics and Lurasidone in The Treatment of Substance-Induced Psychoses: A Narrative Review

VALERIO RICCI, Domenico De Berardis, Giuseppe Maina

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: substance abuse; psychostimulants; schizophrenia; third generation antipsychotics; cariprazine; lurasidone; aripiprazole

Online: 23 January 2024 (18:55:53 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202401.1489.v1

Between the Mother’s Microflora and the Child’s Autism: Is There a Common Pathway?

Maria Suprunowicz, Natalia Tomaszek, Agata Urbaniak, Klaudia Zackiewicz, Stefan Modzelewski, Napoleon Waszkiewicz

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism spectrum disorders; Gut microbiota; Brain-gut axis; Maternal immune activation (MIA); Gastrointestinal; Delivery; Dysbiosis; Neurodevelopment; Microglia, Short-chain fatty acids (SCFA)

Online: 19 January 2024 (12:06:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1404.v1

Investigating the Effectiveness of Brexpiprazole in Schizophrenic Patients with Concurrent Alcohol and Substance Use Disorder: A Prospective, Multicentric, Real-World Study

Stefania Chiappini, Clara Cavallotto, Alessio Mosca, Francesco Di carlo, Tommaso Piro, Chiara Lorenzini, Maria pia Di paolo, Maria Pepe, Marco Di nicola, Valerio Ricci, Mauro Pettorruso, Giovanni Martinotti

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dual disorders; substance use disorder; brexpiprazole; real-world study; addiction; substance-induce-psychosis.

Online: 18 January 2024 (14:03:17 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1222.v1

Exploring the Interplay between Complex PTSD and Obsessive-Compulsive Disorder Severity: Implications for Clinical Practice

Martina D'Angelo, Marta Valenza, Anna Maria Iazzolino, Grazia Longobardi, Valeria Di Stefano, Elena Lanzara, Giulia Visalli, Luca Steardo, Caterina Scuderi, Luca Steardo jr

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: complex post-traumatic stress disorder; obsessive-compulsive disorder; anxiety

Online: 16 January 2024 (10:27:04 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1163.v1

Is Opium Smoking A Cause of Sway Back Posture and Spinal Musculoskeletal Disorders? What is the Relation?

Omid Massah, Amir Masoud Arab, Ali Farhoudian, Mehdi Noroozi, Fahimeh Hashemirad

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: opioids; opium smoking; substance use disorder; behavioral addiction; drug use disorder; sway back posture; musculoskeletal disorders; Nordic; Iran

Online: 16 January 2024 (09:42:41 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0835.v1

Association of Temperament and Character Traits with Suicide Probability, Suicide Attempt and Perceived Stress Level in Patients with Bipolar Disorder

Selma Özdemir Yılmaz, Aylin Ertekin Yazıcı, Hamdi Yılmaz

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: bipolar disorder; suicide attempt; suicidal behavior; temperament; character; personality; perceived stress

Online: 11 January 2024 (10:13:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0668.v1

The Approach of Physiotherapists in the Management of Patients with Persistent Pain and Comorbid Anxiety/Depression: Are There Any Differences between Male and Female Professionals?

Michele Chiesa, Gregorio Nicolini, Massimiliano Buoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: physiotherapy; depression; anxiety; gender; management

Online: 9 January 2024 (10:19:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.2165.v1

The Impact of Postpartum Depression on the Early Parent-Infant Relationship: Perception Versus Reality

Misty Charissa Richards, Camila A. Ferrario, Ying Yan, Nicole M. McDonald

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: postpartum depression; perinatal depression; mother-infant bonding; mother-infant play interactions; Oxytocin

Online: 28 December 2023 (09:50:44 CET)

Show abstract| Download PDF| Share

Preprint SHORT NOTE | doi:10.20944/preprints202312.1904.v1

Living on the Edge: Navigating the Complex Landscape of Borderline Personality Disorder

Sharif Mohammed Sadat, Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Borderline personality Disorder; instability; Impulsive; Stigma; Psychiatry
;

Online: 26 December 2023 (05:40:17 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.1395.v1

Impact of Microbial Pathogens on Suicidal Behavior: A Systematic Review

Ani Zerekidze, Meng Li, Alexander Refisch, Justina Shameya, Thomas Sobanski, Martin Walter, Gerd Wagner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: toxoplasmosis; microbiome; suicide; suicidal behavior

Online: 19 December 2023 (06:20:13 CET)

Show abstract| Download PDF| Share

Preprint SHORT NOTE | doi:10.20944/preprints202312.1064.v1

Schizoaffective Disorder - The Middle Point between Schizophrenia and Psychotic Bipolar

Charmee Patadia, Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizoaffective disorder; Schizophrenia; Bipolar disorder with Psychotic features; Duration of symptoms

Online: 14 December 2023 (09:06:03 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.0995.v1

What Are We Like, Is It a Matter of Genetic Inheritance or Not?

stefano mariano

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: transgenerational epigenetic inheritance; maternal stress; neuro epigenetics; personality trait; environmental epigenetics; prenatal stress

Online: 13 December 2023 (12:16:46 CET)

Show abstract| Download PDF| Share

Background Scientific literature in psychology considers personality as an organization of ways of being, knowing, and acting that ensures unity, coherence and continuity, stability and planning of the individual's relations with the world (Caprara & Gennaro, 1994). Personality is the outcome of two distinct constructs: Temperament and Character. So, personality is the result of the interaction between biological aspects (temperament) and the experiences that anybody experiences in his own life, interacting with the environment (Cloninger et al., 1993). Scientific literature now largely agrees that adversity in the early years of life has broad long-term consequences on the neuroendocrine, immune, and metabolic systems (Kim et al., 2019), as well as on neuroplasticity and neuronal morphology that alter the overall evolution of (van Bodegom, et al., 2017; Edwards et al., 2010). Here we analyze the hypothesis that maternal environmental factors (air and chemical pollutants, maternal health, eating behaviors, maternal and fetal stresses, caregivers' behaviors, etc.) can cause epigenetic alterations in the offspring in the prenatal and perinatal period that shape the trait's personality of the offspring themselves and that orient part of their character in adult life. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used to develop this systematic review. PubMed, Scopus, PsycINFO, and Biosis databases were searched for primary research articles published between 2010 and 2023 looking for English language articles containing the term "prenatal" and any of the following terms: "anxiety"; "brain development"; "depression"; "gestation"; "maternal health"; "maternal stress"; "mental health"; "newborn health"; "perinatal programming"; "pregnancy"; "prenatal stress"; "resilience to stress"; "transgenerational epigenetic inheritance"; "personality"; "personality trait"; "environmental epigenetics". Retrieved articles were screened and a subset of relevant abstracts was then selected for a more detailed evaluation. The final studies selected consisted of those resources that directly evaluated the relationship between maternal environmental factors and the personality traits of the offspring. Results and Conclusions One hundred and eleven studies were identified but only three met the primary question. There is evidence to support the hypothesis of correlations between environmental exposure during the intrauterine fetal period and personality traits of the newborn. Limits: multiple limitations were found based on the lack of research on this specific topic, although such a field of research can be important for developing effective strategies for primary prevention.

Preprint REVIEW | doi:10.20944/preprints202312.0740.v1

Evening-Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors. A Narrative Review.

Luca Magnani, Andrea Aguglia, Jacques Alexander, Alessandra Maiorano, Hélène Richard-Lepouriel, Sidonia Paula Iancau, Andrea Amerio, Alberto Parise, Gianluca Serafini, Mario Amore, Philippe Huguelet, Khoa D. Nguyen, Costanza Alessandra

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronotype; eveningness; E-chronotype; social jet leg; mood dysregulation; seasonality; depression; inflammation; neuroinflammation; suicidal ideation; suicidal behavior

Online: 11 December 2023 (18:00:47 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0290.v1

Evaluating the Causal Relationship of Levo-Carnitine and Risk of Schizophrenia: A Bidirectional Two-Sample Mendelian Randomization Study

Haoyuan Qiu, Zicheng Zhong, Tianxing Wu, Haoran Hu, Meijuan Zhou, Zhijun Feng

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; levo-carnitine; carnitine; mendelian randomization

Online: 6 December 2023 (08:27:18 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0354.v1

Antipsychotics and Mortality in Adult and Geriatric Patients with Schizophrenia

Ling-Ling Yeh, Wei-Chen Lee, Kuei-Hong Kuo, Yi-Ju Pan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: antipsychotic; mortality; schizophrenia; elderly; daily defined dosage

Online: 6 December 2023 (07:45:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0102.v1

Switching to Vortioxetine in Patients with Poor- Tolerated Antidepressant-Related Sexual Dysfunction in Clinical Practice: A 3-Month Prospective Real-Life Study

Angel L. Montejo, Froilan Sanchez-Sanchez, Rubén De Alarcón, Juan Matías, Benjamin Cortés, Claudia Matos, Tomás Martín-Pinto, Peñitas Rios, Nerea González-García, José María Acosta

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Sexual Dysfunction; antidepressant; vortioxetine; depression; sexuality

Online: 4 December 2023 (09:17:50 CET)

Show abstract| Download PDF| Share

Treatment-emergent sexual dysfunction (TESD) is one of the most frequent and persistent adverse effects of antidepressant medication. Sexual dysfunction (SD) secondary to SSRIs occurs in >60% of sexually active patients and >80% of healthy volunteers, with this causing treatment discontinuation in >35% of patients. However, this factor is rarely addressed in routine examinations, and only 15%-30% of these events are spontaneously reported. A strategy of switching to a different non-serotonergic antidepressant could involve a risk of relapse or clinical worsening due to a lack of serotonergic activity. Vortioxetine appears to have less impact on sexual function due to its multimodal mechanism of action. No studies have been published on the effectiveness of switching to vortioxetine in patients with poorly tolerated long-term antidepressant-related SD at naturalistic settings. Study objectives: To determine the effectiveness of switching to vortioxetine due to SD in a routine clinical practice setting. Methodology: observational pragmatic and naturalistic study to determinate the effectiveness of the switch to vortioxetine (mean dosage 13.11±4.03) in 74 patients aged 43.1 ± 12.65 ( 54% males) at risk of discontinuing treatment due to sexual dysfunction. The SALSEX Scale was applied at two moments: baseline visit and after 3 months of follow-up. Results. The global Sexual Dysfunction (SD) measured with the SALSEX Scale, decreased significantly from baseline visit (10.32; SD 2.73) to follow-up visit (3.78; SD 3.68) p<0.001. There was a significant improvement ( p<0.001) at the endpoint including decreased libido, delay of orgasm, anorgasmia and arousal difficulties in both sexes. After switching to Vortioxetine, 83.81% of patients experienced sexual function improvement (43.2% felt greatly improved). Most patients (83.3%) who switched to vortioxetine continued treatment after the follow-up visit. 58.1% of patients showed an improvement in depressive symptoms from baseline visit. Conclusion. Switching to vortioxetine is an effective and reliable strategy to treat patients with poor tolerated previous antidepressant -related sexual dysfunction in the real-life clinical settings.

Preprint REVIEW | doi:10.20944/preprints202311.1547.v2

Is There a Deficit in the Product and Process of Handwriting in Children with Attention‐Deficit Hyperactivity Disorder? A Systematic Review and Recommendations for Future Research

Frédéric Puyjarinet, Yves Chaix, Maëlle Biotteau

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Handwriting; Dysgraphia; Product of handwriting; Process of handwriting

Online: 30 November 2023 (11:20:27 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ESSAY | doi:10.20944/preprints202311.1756.v1

Logics of Discovery III: What ‘Sleeps’ When We Are Dreaming? Dream Consciousness as Suspension of the ‘Will’ to Narratively Organise Our Experiences

Giovanni Stanghellini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Co-production; dream consciousness; Guido Morselli; identity obsession; narrative obsession; now-vigilance; self

Online: 28 November 2023 (07:21:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1606.v1

Associations between Gender Expression, Protective Coping Strategies, Alcohol Saliency, and High-Risk Alcohol Use in Post-Secondary Students at Two Canadian Universities

Anees Bahji, Paul Boonmak, Michelle Koller, Christina Milani, Cate Sutherland, Salinda Horgan, Shu-Ping Chen, Scott Patten, Heather Stuart

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Gender expression; High-risk alcohol use; Protective coping strategies; Canadian universities

Online: 27 November 2023 (07:16:19 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1587.v1

Self-Esteem and Occupational Factors as Predictors of the Incidence of Anxiety and Depression among Health Workers during the COVID-19 Pandemics in Latvia

Laura Valaine, Māra Grēve, Maksims Zolovs, Gunta Ancāne, Artūrs Utināns, Ģirts Briģis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: self-esteem; occupational factors; depression; anxiety; healthcare workers; Covid-19

Online: 26 November 2023 (06:21:45 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202311.1547.v1

Is There a Deficit in the Product and Process of Handwriting in Children with Attention‐Deficit Hyperactivity Disorder? A Systematic Review and Recommendations for Future Research

Frédéric Puyjarinet, Yves Chaix, Maëlle Biotteau

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Handwriting; Dysgraphia; Product of handwriting; Process of handwriting.

Online: 24 November 2023 (08:24:05 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1117.v1

Association of Depression and Anxiety with Sexual Orientation in a Convenience Sample of Latvian Young Adults

Marija Pavlukovica, Anatolijs Pozarskis, Anda Kivite-Urtane

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Depression; Anxiety; Sexual orientation; Violence; Mental health

Online: 16 November 2023 (15:16:48 CET)

Show abstract| Download PDF| Share

Background. Depression and anxiety and its association with sexual orientation in Latvia is un-derstudied. Outcomes. Kinsey scale, primary outcomes for mental health disturbances were defined as per-son`s subjective feeling of depression and anxiety. Materials and Methods. Participants aged 18-30 year old (n=503) was asked to do a self-administered anonymous web-based survey regarding social and family status, sexual iden-tification and behaviour, violence experience and mental health information. To describe person`s sexual orientation Kinsey scale was used. Prevalence of depression and anxiety, univariate and multivariate regression analysis was performed to measure relations between investigated fac-tors. Results. A total of 503 participants (i.e., 365 females, 133 males, 5 others) were included in the study. Mean (SD) age of participants was 23.0 (3.7) years. Mean (SD) value on the Kinsey scale was 1.4 (1.8) and median (IQR) value was 1.0 (0-2.0) where 1 is defined as ‘mostly heterosexual, only slightly homosexual’ person and 2 is ‘mostly heterosexual, but more than slightly homosexual’. Prevalence of persons reported violence experience was 20.3%, anxiety 56.3% and depression 37.6%. Logistic regression analysis showed that experience of violence was associated with higher odds of developing anxiety and depression (OR: 2.6 [95% CI: 1.7-4.0] and 2.4 [95% CI: 1.5-3.9], respectively). Being in relationship was associated with higher odds of developing anxiety (OR: 2.8[95% CI: 1.3-6.3]). Male sex and income 1001-2000 euros a month were associated with lower odds of developing anxiety (OR: 0.4 [95% CI: 0.2-0.5] and aOR: 0.3 [95% CI: 0.1-0.8], respectively). Sexual orientation showed no significant value in association with anxiety and depression (OR: 1.1 [95% CI: 1.0-1.2] and OR: 1.1 [95% CI: 1.02-1.2], respectively). Conclusions. In our study, the significant factors for developing depression and anxiety were experiencing violence, being female, being in a relationship, and having no income, while sexual orientation showed no significance in relation to depression and anxiety.

Preprint ARTICLE | doi:10.20944/preprints202311.1113.v1

Circadian Rhythms and Depression in Adolescents: A Comparative Analysis of First Episode and Recurrent-Episode Groups

Youngsoo Jang, Hye-mi Cho, Young-Eun Mok, Su-hyuk Chi, Changsu Han, Moon-Soo Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Circadian rhythm; Adolescent; Depressive disorder; chronicity

Online: 16 November 2023 (14:38:55 CET)

Show abstract| Download PDF| Share

Circadian rhythm disruptions are a hallmark feature of mood disorders. Patients experiencing acute depressive episodes report noticeable changes in their sleep-wake cycles. This research explains the association between depression and various circadian rhythm metrics, explicitly focusing on adolescents diagnosed with depressive disorders. Adolescence is a critical period marked by significant physiological and psychological changes, making it imperative to understand how mood disorders manifest during this phase. However, there have been minimal specific studies in pediatric populations to determine whether circadian rhythm changes differ between adolescents with first- and multiple-recurrent depressive episodes. Our study involved a group of 61 adolescents aged between 13 and 18. We performed a cross-sectional study of a clinical popu-lation of patients presenting to a child and adolescent psychiatry clinic diagnosed with depression. Participants were asked to complete self-report evaluations using several tools: The Korean ver-sion of the Biological Rhythms Interview of Assessment in Neuropsychiatry (K-BRIAN), the Korean Translation of Composite Scale to Measure Morningness-Eveningness (KtCS), and the Seasonal Pattern Assessment Questionnaire (SPAQ). Tools such as the Children's Depression In-ventory (CDI), State-Trait Anxiety Inventory (STAI), and K-Mood Disorder Questionnaire (K-MDQ) were employed for the assessment of clinical characteristics of depression. Based on the frequency of their depressive episodes, participants were bifurcated into two distinct groups: those experi-encing their first episode (n=22, mean age: 15.09±1.44 years) and those with recurrent episodes (n=39, mean age: 15.95±1.26 years). At first, the two groups' data revealed no significant differences regarding mood or circadian rhythm metrics (CDI: first-episode 26.18±10.54 and recurrent episode 25.90±10.59, STAI-S: first-episode 56.91±12.12 and recurrent episode 57.49±11.93, STAI-T: first-episode 60.36±11.63 and recurrent episode 59.09±12.10, SPAQ-total: first-episode 6.59±4.86 and recurrent episode 6.77±5.23, KtCS: first-episode 30.32±5.83 and recurrent episode 28.13±7.36). However, we observed significant correlations between circadian rhythm disruptions and depression scales (CDI with SPAQ-weight (r=0.26), KtCS (r=-0.48), K-BRIAN-sleep (r=0.58), K-BRIAN-activity (r=0.64), K-BRIAN-social (r=0.71) and K-BRIAN-eating (r=0.40)). These correlations were especially pronounced in the recurrent episode group, suggesting that with the progression and chronicity of depression, the relationship between circadian rhythms and depression becomes more intertwined and evident. In conclusion, especially in adolescents, as the severity and chronicity of depression increase, the interplay between circadian rhythms and mood disorders becomes more pronounced, warranting further research and clinical attention.

Preprint ARTICLE | doi:10.20944/preprints202311.0910.v1

Impact of Selective Serotonin Reuptake Inhibitor on Male Infertility: A Retrospective Pilot Study

Jawza F. Alsabhan, Haya M. Almalag, Lulu A. Alnuaim, Awatif B. Albaker

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Antidepressants; Infertility; Males; Semen Quality; SSRIs

Online: 14 November 2023 (12:02:00 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0830.v1

Protective Effects of Whey Protein Hydrolysate, Treadmill Exercise, and Their Combination Against Scopolamine-induced Cognitive Deficit in Mice

Yeok Boo. Chang, Eun-Jin Jung, Hyung Joo. Suh, Hyeon-Son Choi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: whey protein hydrolysate; LDIQK; neuroprotective effect; treadmill exercise; scopolamine

Online: 13 November 2023 (13:46:56 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0704.v1

TREE: Reducing the Use of REstrictive Practices on Psychiatric Wards through Virtual REality Immersive Technology Training

Peter Phiri, Laura Pemberton, Yang Li, Xiaojie Yang, Joe Salmon, Isabel Boulter, Sana Sajid, Jackie Clark, Andy McMillan, Jian Shi, Gayathri Delanerolle

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Virtual Reality; restrictive practices; inpatient wards; restraint; isolation; rapid tranquilisation; covert medication; procedural restrictions; health professions training

Online: 10 November 2023 (11:11:28 CET)

Show abstract| Download PDF| Share

BACKGROUNDRestrictive practices are defined by measures linked to physical and chemical restraints to reduce the movement or control behaviours during any emergency. Seclusion is an equal part of restrictive practices intended to isolate and reduce the sensory stimulation to safeguard the patient and those within the vicinity. Using interventions by way of virtual reality (VR) could assist with reducing the need for restrictive practices as it could help reduce anxiety or agitation by way of placing users into realistic and immersive environments. This could also aid staff to and change current restrictive practices.AIMTo assess the feasibility and effectiveness of using a VR platform to provide reduction in restrictive practice (RRP) training. METHODSThe study received ethics approval was obtained prior to starting the study from the Health Research Authority in United Kingdom (22/HRA/3030 REFERENCE). A randomised controlled feasibility study was conducted alongside of an evaluation at at 1 month and 6 within inpatient psychiatric wards at Southern Health NHS Foundation Trust, UK. Virti Virtual Reality scenarios will be used on VR headsets to provide training on reducing restrictive practices in 3 inpatient psychiatric wards. Outcome measures included General Self-Efficacy (GSE) scale, Generalised Anxiety Disorder Assessment 7 (GAD-7), Burnout Assessment Tool (BAT-12), The Everyday Discrimination (EDS) Scale, and the Compassionate Engagement and Action (CEA) Scale. RESULTSThe statistical significance of most variables is high, with the exception of the BAT12 score, compassionate engagement to others score, compassionate to others total score, compassionate engagement from others score, and compassionate from others total score, which exhibit lower statistical power in two-sample t-tests. To assess the acceptability, preference, and adherence of users to the Virti VR technology for RRP training, we calculated the System Usability Scale (SUS) scores and visualized the program's completion using pie charts. The majority of respondents reported SUS scores exceeding 70, with a mean SUS score of 71.79. In accordance with the insights provided by Bangor et al. (38), the VR platform demonstrated superior usability compared to approximately 62% of other products. we utilized the GAD7 score to assess the confidence levels within the two groups. We compared the data for the VR group and the control group after one month, as well as the baseline and one-month data for both the VR group and the control group. Given that the p-values are below 0.05 and the statistical power is high, it can be concluded that there are no statistically significant differences in confidence levels between the VR and control groups at baseline and day-30. CONCLUSIONSOur study has revealed the challenges associated with implementing such a program, even though the staff has given it high usability ratings. With the ongoing advancement of VR technology, we have the capability to create scenarios and simulations tailored to various healthcare environments. This empowers staff to receive more comprehensive and effective training for handling a wide range of situations.

Preprint ARTICLE | doi:10.20944/preprints202311.0589.v1

Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-suicidal Self-Injury in Females with Non-psychotic Mental Disorders and Suicidal Ideation

Mikhail S. Zinchuk, Tatyana A Druzhkova, Sofya B. Popova, Marina Y. Zhanina, Alla B. Guekht, Natalia V. Gulyaeva

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: non-suicidal self-injury (NSSI); non-psychotic mental disorder; suicidal ideation; stress, hypothalamic-pituitary-adrenal (HPA) axis; cortisol; adrenocorticotropic hormone (ACTH); brain-derived neurotrophic factor (BDNF); early adverse experience

Online: 9 November 2023 (07:27:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0556.v1

Genetic Psychophysiology and Markers of Resilience to Anxiety and Depression in Sports and Extreme Professions

Irma Mosse, Inna Charykova, Elena Stepanova, Darya Smetanina, Aleksei Riabinin, Nikita Sedlyar, Tatsiana Talako, Milos Ljubisavljevic, Yauhen Statsenko

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Sports; Psychogenetics; Psychophysiology; Elite athletes; Stress-resistance; Machine learning; Extreme professions; Depression; Anxiety

Online: 8 November 2023 (13:55:11 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0452.v1

Psychometric Properties of the Slovenian Version of Brief Sensation Seeking Scale

Andrej Kastrin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sensation seeking; Brief Sensation Seeking Scale; BSSS-8; psychometric properties

Online: 8 November 2023 (01:28:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.2097.v1

A Pilot Multisensory Approach for Emotional Eating: Pivoting from VR to a 2-D Telemedicine Intervention during the Pandemic

Clelia Malighetti, Ciara Kelly Schnitzer, Sophie Lou YorkWilliams, Luca Bernardelli, Cristin Runfola, Giuseppe Riva, Debra L. Safer

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotional eating; eating disorder; binge-eating disorder; bulimia nervosa; virtual reality; treatment; somatic marker

Online: 1 November 2023 (03:53:18 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202310.0976.v1

Current Evidence and Future Perspective in the Exploration of Sleep-Related Eating Disorder—From Pathogenic Hypotheses to Treatment Approaches

Octavian Vasiliu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep-related eating disorder; night eating syndrome; parasomnia; disorders of arousal; topiramate; clonazepam; pramipexole; zolpidem

Online: 17 October 2023 (08:11:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0961.v1

Do Patients with Autism Spectrum Disorder Receive More Sedatives in the Emergency Department? A Case Matched Cohort Study

Ramesh Arasu, Soumitra Das, Naveen Thomas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism spectrum disorder,; psychiatry; sedation; benzodiazepines; behavioural management; emergency medicine

Online: 16 October 2023 (10:33:52 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0775.v1

Prevalence of and Gender Differences in Psychiatric Disorders among Juvenile Detainees in South Korea: A Comparative Study

Bum-Sung Choi, Bongseog Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Juvenile detainees; psychiatric disorder; conduct disorder

Online: 12 October 2023 (05:38:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0763.v1

A Comparative Study of Anxiety, Depression, Suicidal Ideation, and Self-Esteem in Students with or without ADHD

Bum-Sung Choi, Ji-hoon Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; anxiety; depression; suicidal ideation; self-esteem

Online: 12 October 2023 (05:19:08 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.0771.v1

Recent Progresses in Neural Networks for Alzheimer's Disease Detection

Mengyao Zhao

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer's disease; neural networks; Training and learning; early diagnosis; drug discovery; brain diseases

Online: 12 October 2023 (04:19:37 CEST)

Show abstract| Download PDF| Share

This article reviews the introduction of Alzheimer's Disease (AD), neural networks, training and learning of neural networks, applications of neural networks in early diagnosis of AD, applications of neural networks in AD drug discovery, other brain diseases, and challenges faced by AD. First, the paper introduces the background and characteristics of AD. AD is a degenerative neurological disorder characterized by impaired memory, decreased cognitive function, and loss of neurons. These characteristics place a huge burden on the lives and families of patients. Next, the basic principle and structure of neural network are discussed. A neural network is a computational model made up of multiple neurons that can perform tasks by learning and adapting to input data. In particular, the key concepts of neural network hierarchy, activation function and weight adjustment are discussed. Then, the training and learning methods of neural networks are discussed. Common techniques such as backpropagation algorithm and gradient descent optimizer are introduced in detail, as well as the importance of data preprocessing and model evaluation. Next, the paper focuses on the application of neural network in early diagnosis of AD. By extracting features from brain image data, neural networks can automatically identify differences between AD patients and healthy subjects, enabling early diagnosis and intervention. In addition, the application of neural networks in AD drug discovery is also discussed. By analyzing and predicting a database of known drugs, neural networks can help discover potential treatments for AD and speed up the drug discovery process. The paper further explores the application of neural networks in other brain diseases and highlights the challenges faced by AD, such as the lack of reliable biomarkers, complex pathological mechanisms, etc. In summary, this paper presents a systematic overview of AD, neural networks, training and learning of neural networks, applications of neural networks in early diagnosis of AD and drug discovery, and other brain diseases and challenges associated with AD.

Preprint REVIEW | doi:10.20944/preprints202310.0420.v1

Grappling with the Issue of Motherhood in Women with Schizophrenia

Mary V. Seeman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Antipsychotics; Child Custody; Interventions; Mothers; Parenting; Schizophrenia; Stigma; Support; Women

Online: 8 October 2023 (03:31:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0182.v1

Personality Disorders and Traits of ABC Clusters in Fibromyalgia

Dmitry V. Romanov, Tatiana I. Nasonova, Aleksey I. Isaikin, Olga V. Filileeva, Andrey M. Sheyanov, Polina G. Iuzbashian, Evgenia I. Voronova, Vladimir A. Parfenov

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: fibromyalgia, personality disorders, Axis II, personality disorders clusters, personality traits, borderline, schizotypal, schizoid, avoidant

Online: 4 October 2023 (07:51:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0029.v1

Vitamin D status in Bipolar Disorder

Zita Späth, Adelina Tmava-Berisha, Frederike T. Fellendorf, Tatjana Stross, Alexander Maget, Martina Platzer, Susanne A. Bengesser, Alfred Häussl, Ina Zwigl, Armin Birner, Robert Queissner, Katharina Stix, Linda Wels, Melanie Lenger, Nina Dalkner, Sieglinde Zelzer, Markus Herrmann, Eva Z. Reininghaus

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: bipolar disorder; vitamin D metabolism; functional vitamin D deficiency; 25(OH)D; 24,25(OH)2D; VMR

Online: 2 October 2023 (03:58:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1850.v1

Deepening Depression in Women Balancing Work-Life and Caregiving during the COVID-19 Pandemic: Findings of Gender-Specific Face-to-Face Street Interviews Conducted in Italy

Laura Giusti, Silvia Mammarella, Sasha Del Vecchio, Anna Salza, Massimo Casacchia, Rita Roncone

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Women; depression; family burden; family functioning; pandemic COVID-19; collective traumas

Online: 27 September 2023 (08:33:42 CEST)

Show abstract| Download PDF| Share

Purpose: This study investigated the impact of the COVID-19 pandemic on mental health, quality of life, and family functioning in a sample of the general female population, exploring difficulties encountered in managing family and work responsibilities and burden of care when taking care of a loved one. The study was moreover aimed at investigating factors capable of influencing severe depressive symptomatology in the context of socio-demographics, traumatic events, individual vulnerability, and family functioning. Method: During a weekend devoted to Mental Health initiatives (October 8-10, 2021), 211 women were interviewed (47% exposed to the 2009 L’Aquila earthquake). Results: More than 50% of the sample reported a higher complexity in managing their lives during the COVID-19 pandemic compared to their previous routine, with no statistically significant differences between working women and non-workers, although the latter obtained higher scores for depressive symptomatology and poorer quality of life. Compared to non-caregivers, women caregivers (22.3%) in charge of the care of loved ones affected by physical (10.9%) or psychiatric disabilities (11.4%) complained of a poorer quality of life, with those caring for people affected by mental disorders seeming to experience a more significant worsening. Approximately 20% of the total sample reported severe depressive symptomatology. Previous access to mental health services (O.R. 10.923), low level of education (O.R. 5.410) and difficulties in management of their everyday lives during the COVID-19 pandemic (O.R. 3.598) were found to be the main variables predictive of severe depressive psychopathology. Old age, good problem-solving skills and ability to pursue personal goals were identified as protective factors. Conclusions: The COVID-19 pandemic underlined the need for support for emotionally vulnerable women with pre-existing mental health conditions, partly reflecting the cumulative effects of traumas.

Preprint ARTICLE | doi:10.20944/preprints202309.1566.v1

CYP2D6 and CYP2C19 Variant Coverage of Commercial Antidepressant Pharmacogenomic Testing Panels Available in Victoria, Australia

Malcolm Forbes, Mal Hopwood, Chad Bousman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pharmacogenetics; psychiatry; personalized medicine; CYP2D6; CYP2C19

Online: 22 September 2023 (11:46:06 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.1547.v1

Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review

Joshua Sauren, David Hoehfeld, Leif Gerrit Keferstein

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; mental health; interventions; hyperbaric oxygen therapy; cryotherapy; dietary patterns; fasting; light therapy; probiotics; exercise; metabolic markers

Online: 22 September 2023 (10:18:19 CEST)

Show abstract| Download PDF| Share

Background: Depression, a multifaceted mental health condition, necessitates a multidimensional approach to treatment. This study aimed to elucidate the potential efficacy of various mitochondrial interventions, ranging from pharmacological treatments to lifestyle modifications, in alleviating depressive symptoms and enhancing overall mental well-being and assess the diverse range of mitochondrial assessments for managing depression by synthesizing findings from selected studies. Methods: A systematic compilation of studies, employing observational, interventional, and animal-based designs, was undertaken to elucidate the intricate relationship between mitochondrial function and depression as well as depressive signs and symptoms. The PRISMA guidelines were employed for conducting this review and a specific set of selection criterion were formulated by a team of reviewers for selection of relevant papers. Results: The synthesized results from the 21 selected papers highlighted the potential of these interventions to target diverse aspects of depression. Hyperbaric oxygen therapy and psychotherapy demonstrated significant reductions in depression and anxiety scores, with hyperbaric oxygen therapy particularly effective in improving nerve function and daily living activities. Whole-body cryotherapy displayed substantial improvements in depressive symptoms and quality of life. Frequent sauna bathing exhibited a lower risk of depressive symptoms in males. Dietary patterns, including Paleolithic and Mediterranean diets, showcased potential protective effects against depression, anxiety, and stress. The ketogenic diet revealed promise in ameliorating depression and psychosis symptoms alongside positive metabolic changes. Fasting interventions, though challenging, were associated with lower anxiety and depression levels without increased fatigue. Bright white light therapy enhanced remission rates and reduced depression scores in bipolar depression. Probiotic supplementation exhibited potential in reducing depression scores and improving metabolic markers, although further investigation is warranted. Conclusion: The diverse array of interventions explored in this study underlines the multifaceted nature of depression treatment. While these findings offer hope for more personalized and effective approaches, it is imperative to consider the variability in study designs, sample sizes, and methodologies among the selected papers. The mechanisms underlying the observed effects remain partially understood, emphasizing the need for continued mechanistic research. This study sets the stage for future investigations and clinical practices, showcasing the potential of various interventions in mitigating the challenges posed by depression and paving the way for more effective treatment strategies.

Preprint REVIEW | doi:10.20944/preprints202309.1485.v1

Biomarkers of Postpartum Depression: A Narrative Review

Stefan Modzelewski, Aleksandra Julia Oracz, Kamila Iłendo, Aleksandra Sokół, Napoleon Waszkiewicz

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: postpartum depression, marker, biomarkers, peripartum, postpartum, cytokines, HPA, oxidative stress, genetics, nutrients, pathogenesis

Online: 22 September 2023 (05:13:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1358.v1

Associations between Sleep Hygiene and Mental Complaints in a French Healthcare Workers Population during COVID-19 Crisis: A Cross-Sectional Analysis to Personalize Sleep Health Interventions

Julien Coelho, Jean-Arthur Micoulaud-Franchi, Pierre Philip

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep; social jetlag; healthcare workers; regularity; occupational health

Online: 20 September 2023 (04:53:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1091.v1

The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation

Bruno Roméo, Valentine Lestra, Catherine Martelli, Ammar Amirouche, Amine Benyamina, Nora Hamdani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; T. gondii; cannabis use; eosinophils counts

Online: 18 September 2023 (13:25:31 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0617.v1

Recent Advances in Psychotherapeutic Treatment and Understanding of Alexithymia in Patients with Obesity and Diabetes Mellitus Type 2

Filip Mustač, Tin Galijašević, Eva Podolski, Andrej Belančić, Martina Matovinović, Darko Marčinko

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alexithymia; obesity; diabetes mellitus type 2; psychodynamic psychotherapy

Online: 11 September 2023 (09:21:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0452.v1

Parental Control and Children's Short Sleep Duration and Difficulties as Predictors of Screen Time: The Japanese Context

Yusuke Arai, Daimei Sasayama, Kazuhiro Suzuki, Toshinori Nakamura, Yuta Kuraishi, Shinsuke Washizuka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: screen time; SDQ; sleep; parental control

Online: 7 September 2023 (09:24:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202308.2204.v1

The Impact of Stress from Social Isolation During the COVID-19 Pandemic on Neuropsychiatric Disorders: An Analysis from Scientific Literature

Amanda Gollo Bertollo, Geórgia de Carvalho Braga, Paula Teresinha Tonin, Adriana Remião Luzardo, Margarete Dulce Bagatini, Zuleide Maria Ignácio

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; Social isolation stress; Neuropsychiatric disorders; Biopsychosocial vulnerability; Therapeutic strategies

Online: 1 September 2023 (07:30:29 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202308.1847.v1

MDMA-Based Psychotherapy in Treatment-Resistant Post-traumatic Stress Disorder (PTSD): A Brief Overview of Current Evidence

Kainat Riaz, Sejal Suneel, Mohammad Hamza Bin Abdul Malik, Tooba Kashif, Irfan Ullah, Abdul Waris, Marco Di Nicola, Marianna Mazza, Gabriele Sani, Giovanni Martinotti, Domenico De Berardis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Post-traumatic stress disorder; MDMA; Psychotherapy; Breakthrough Therapy

Online: 28 August 2023 (09:56:04 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1699.v1

Resources and Obstacles of Maternity Staff Facing Intimate Partner Violence during Pregnancy–A Qualitative Study

Yam Sureau, Marie-Rose Moro, Rahmeth Radjack

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: intimate partner violence; pregnancy; gestatinoal intimate partner violence; adverse outcomes; maternity staff; screening; domestic abuse; trauma; institutional support; teamwork

Online: 24 August 2023 (09:44:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1686.v1

Effect of Assisted Physical Exercise over Inflammatory Markers and Lactate in Schizophrenia—A Controlled Trial

Viviane Batista Cristiano, Michele Fonseca Szortyka, Paulo Silva Belmonte-de-Abreu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; Lactate; Physical exercise; Creatine Kinase (CK); C-Reactive Protein (CRP)

Online: 24 August 2023 (08:20:32 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1305.v1

Alexithymia, Burnout and Hopelessness in a Large Sample of Healthcare Workers during the Third Wave of COVID-19 in Italy

Domenico De Berardis, Anna Ceci, Emanuela Zenobi, Dosolina Rapacchietta, Manuela Pisanello, Filippo Bozzi, Lia Ginaldi, Viviana Marasco, Maurizio Brucchi, Guendalina Graffigna, Jacopo Santambrogio, Antonio Ventriglio, Marianna Mazza, Giovanni Muttillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alexithymia; burnout; hopelessness; healthcare workers; HCWs; Covid-19; pandemic

Online: 18 August 2023 (10:00:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1110.v1

Change in Ultra-Processed Food Consumption Moderates Clinical Trial Outcomes in Depression: A Secondary Analysis of the SMILES Randomised Controlled Trial

Melissa M Lane, Mojtaba Lotfaliany, Priscila Machado, Felice N Jacka, Mohammadreza Mohebbi, Adrienne O’Neil, André O Werneck, Carlos Monteiro, Amy Loughman, Tetyana Rocks, Nikolaj Travica, Michael Berk, Rachelle S Opie, Wolfgang Marx

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ultra-processed food; Nova food classification system; major depressive disorder; nutritional psychiatry; secondary analysis; randomised controlled trial

Online: 15 August 2023 (09:38:10 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint CASE REPORT | doi:10.20944/preprints202308.1023.v1

Cariprazine in an Adolescent with Tourette Syndrome with Comorbid ADHD and Depression: A Case Report

Jesjeet Singh Gill

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cariprazine; Tourette syndrome; major depressive disorder; ADHD; tics

Online: 14 August 2023 (10:21:48 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0981.v1

Sarcosine May Induce EGF Production or Inhibit the Decline in EGF Concentrations in Patients with Chronic Schizophrenia (Results of the PULSAR Study)

Agnieszka Pawlak, Bartosz Kaczmarek, Adam Wysokiński, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: EGF; sarcosine; schizophrenia; negative symptoms

Online: 14 August 2023 (04:47:40 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0759.v1

Application of the Delphi Method for the Design and Content Validity Analysis of a Questionnaire to Determine the Risk Factors of the Chemsex

Pablo Del Pozo-Herce, Antonio Martínez-Sabater, Elena Chover-Sierra, Vicente Gea-Caballero, Pedro José Satústegui-Dordá, Carles Saus-Ortega, Clara Isabel Tejada-Garrido, Mercedes Sánchez-Barba, Jesús Pérez, Raúl Juárez-Vela, Iván Santolalla-Arnedo, Enrique Baca-García

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Delphi technique; Expert consensus; Validity; Experts judgment; psychometrics

Online: 9 August 2023 (10:34:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0353.v1

Attachment and Coping in the Second Pandemic Year: the Impact on Loneliness and Emotional Distress

Andrei Hopulele-Petri, Mihaela Fadgyas-Stănculete, Mirela Manea

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: loneliness; covid-19; attachment; coping, mental health

Online: 4 August 2023 (03:17:18 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202307.2148.v1

Autoimmune Encephalitis with Antibodies: Anti-NMDAR, Anti-AMPAR, Anti-GQ1b, Anti-DPPX, Anti-CASPR2, Anti-LGI1, Anti-RI, Anti-Yo, Anti-Hu, Anti-CV2 and Anti-GABAAR, in the Course of Psychoses, Neoplastic Diseases and Paraneoplastic Syndromes

Michał Braczkowski, Dariusz Soszyński, Alicja Sierakowska, Ryszard Braczkowski, Klaudia Kufel, Beata Łabuz-Roszak

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: autoimmune inflamation with antibodies,; anti-NMDAR antibodies,; anti-AMPAR antibodies,; anti-GQ1b antibodies,; anti-DPPX antibodies,; anti-CASPR2 antibodies,; anti-LGI1 antibodies,; encephalitis,; psychoses

Online: 1 August 2023 (11:37:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.2024.v1

Application of Predictive Psychological Nursing in Outpatient Indwelling Needle Intravenous Infusion Nursing

Nianhong Luo, Yan Chen, Yuhong Nie, Fei Chen, Wenjun Chang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: predictive psychological nursing; outpatient service; indwelling needle intravenous infusion; nursing application

Online: 31 July 2023 (03:03:50 CEST)

Show abstract| Download PDF| Share

Objective: To explore the application effect of predictive psychological nursing in the nursing of outpatients with indwelling needle intravenous infusion .Methods: Select 80 patients who received intravenous indwelling needle infusion therapy in the outpatient department of our hospital from January 2022 to December 2022 as the research objects , and divided them into observation group and experimental group according to the different nursing plans received by the patients . 40 cases in each group. The observation group received routine nursing intervention, and the experimental group received predictive psychological nursing intervention. The puncture situation, psychological state level, self-care ability, adverse reactions and nursing satisfaction were compared between the two groups of patients .Results: The puncture success rate of the observation group was 72.5% (29/40), and that of the experimental group was 95.0% (38/40). The puncture success rate of the experimental group was significantly higher than that of the observation group (P<0.05) ; The SAS scores and SDS scores of the treatment group after nursing were significantly lower than those of the observation group (all, P<0.05) ; the self-care skills, self-concept, self-responsibility, health knowledge and ESCA total scores of the experimental group after nursing were significantly higher than those of the observation group. group (all, P<0.05); the incidence of adverse reactions in the observation group was 25.0% (10/40), the incidence of adverse reactions in the experimental group was 7.5% (3/40), and the incidence of adverse reactions in the experimental group was significantly lower than that in the observation group group (P<0.05); the nursing satisfaction of the observation group was 80.0% (32/40), and the nursing satisfaction of the experimental group was 100.0% (40/40), and the nursing satisfaction of the experimental group was significantly higher than that of the observation group (P<0.05 ).Conclusion: The application effect of the predictive psychological nursing intervention model in the outpatient department for intravenous indwelling needle infusion therapy is significant. The implementation of this model can effectively improve the success rate of puncture, improve the patient's psychological state, improve the self-care ability of patients, and reduce the adverse effects of patients. Risk of reaction, so as to further obtain the satisfaction and recognition of patients and their families.

Preprint ARTICLE | doi:10.20944/preprints202307.1774.v1

Reliability and Validity of the Polish Version of the Schema Mode Inventory (SMI)

Anna Grażka, Klara Królewiak, Klaudia Sójta, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schema therapy; schema mode; psychometric properties; reliability; validity

Online: 26 July 2023 (07:30:14 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1682.v1

Does Asthma Disrupts Psychological Wellbeing in Pregnancy?

Paola C. Fernández-Paredes, Eva Morales, Concepción Lopez-Soler, Luis Garcia-Marcos

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Asthma; Pregnancy; Psychological test; Family Apgar; Edinburgh Scale; STAI Inventory; NELA cohort

Online: 25 July 2023 (10:29:41 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202307.1427.v1

Avatar Intervention for cannabis use disorder in a patient with schizoaffective disorder: A case report

Sabrina Giguère, Laura Dellazizzo, Mélissa Beaudoin, Marie-Andrée Lapierre, Marie Villeneuve, Kingsada Phraxayavong, Stéphane Potvin, Alexandre Dumais

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Cannabis use disorder, Virtual reality therapy, Psychotic disorder, Case report, Addiction intervention, Relational treatment.

Online: 20 July 2023 (11:23:33 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1259.v1

Utilizing Real-Time Heart Rate Variability during Psychological Intervention Program for Complex Post-Traumatic Stress Disorder: A Case Study

Bohye Im, Jooyoung Keum, Taeeun Kim, Kyo-il Lee, Kyo-in Koo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: real time; heart rate variability; psychological intervention program; complex posttraumatic stress disorder

Online: 19 July 2023 (09:42:40 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1256.v1

The Correlation between Neck Pain and Disability, Forward Head Posture and Hyperkyphosis with Opium Smoking in the Most Prevalent Opium Smoking Persian Gulf Country; a Cross-sectional Study from Iran

Omid Massah, Amir Masoud Arab, Ali Farhoudian, Mehdi Noroozi, Fahimeh Hashemirad

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Opiates, Opium smoking, Neck pain, Neck disability, Forward head posture, Hyperkyphosis, Drug use disorder, Iran

Online: 18 July 2023 (15:56:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1177.v1

Machine Learning Analysis of Social Media Posts Written in Natural Language May Enhance Suicidal Ideation Detection in Romanian Adults with Major Depression

Eduard P. Drima MD, PhD

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Suicidal Ideation, major depression in adults, natural language written texts, Romanian depression support forum, machine learning text mining,

Online: 18 July 2023 (07:44:06 CEST)

Show abstract| Download PDF| Share

Medicine and Pharmacology