Ferrante, M.; Cristaldi, A.; Oliveri Conti, G. Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review. J. Pers. Med.2021, 11, 500.
Ferrante, M.; Cristaldi, A.; Oliveri Conti, G. Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review. J. Pers. Med. 2021, 11, 500.
Ferrante, M.; Cristaldi, A.; Oliveri Conti, G. Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review. J. Pers. Med.2021, 11, 500.
Ferrante, M.; Cristaldi, A.; Oliveri Conti, G. Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review. J. Pers. Med. 2021, 11, 500.
Abstract
The environmental exposure of human in the daily and occupational activities to plasticizers may adversely affect human health, and thus represents a global issue. The altered expression of MicroRNAs (miRNAs) exerts an important pathogenic role linked also to the exposure to plasticizers. This systematic review summarizes the recent findings showing modified ex-pression of miRNAs in cancer due to plasticizers exposures. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the past ten years, focusing on the relationship between plasticizer exposures and expression of miRNAs cancer. Starting by 535 records, 17 articles were included. Results support the hypothesis that exposure to plasticizers cause changes or deregulation of a number of oncogenic miRNAs and showed that plasticizers interaction with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22; miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolisms that participate in many overlapped cellular processes, and miRNA level changes can be a useful tool for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers
Keywords
Plasticizers; Cancer; microRNA; in vitro study; PRISMA.
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
