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Preprint CASE REPORT | doi:10.20944/preprints201912.0264.v2

4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy

Csaba Tóth, Andrea Dabóczi, Madhvi Chanrai, Mária Schimmer, Katalin Horváth, Zsófia Clemens

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: glioblastoma; brain tumor; paleolithic diet; ketogenic diet; paleolithic ketogenic diet; metabolic therapy; intestinal permeability; cancer treatment

Online: 9 November 2020 (11:25:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0291.v1

Co-infection of Coronavirus Disease 2019 and Influenza: A Report from Iran

Zohre Khodamoradi, Mohsen Moghadami, Mehrzad Lotfi

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: co-infection; coronavirus disease 2019; COVID-19; influenza

Online: 19 March 2020 (02:00:47 CET)

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Preprint ARTICLE | doi:10.3390/sci2040077

Atmospheric Temperature and CO<sub>2</sub>: Hen-or-Egg Causality?

Demetris Koutsoyiannis, Zbigniew Kundzewicz

Subject: Environmental And Earth Sciences, Environmental Science Keywords: temperature; global warming; greenhouse gases; atmospheric CO₂ concentration

Online: 20 October 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0375.v1

Unexpected Co-infection with Different Strains of SARS-CoV-2 in Patients with COVID-19

Hayder O. Hashim, Mudher K. Mohammed, Mazin J. Mousa, Hadeer H. Abdulameer, Alaa T.S. Alhassnawi, Safa A. Hassan, Mohammed Baqur S. Al-Shuhaib

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: co-infection; SARS-CoV-2; pike glycoprotein; stop mutations

Online: 17 September 2020 (05:33:59 CEST)

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There is a rising global concern for the ongoing outbreak of SARS-CoV-2 due to its high transmission rate and unavailability of treatment. Through the binding of its spike glycoprotein with angiotensin type 2 (ACE2), SARS-CoV-2 can efficiently get in the cells of patients and start its pandemic cycle. Herein, the biological diversity of SARS-CoV-2 infection was assessed in Babylon province of Iraq by investigating the possible genetic variations of the spike glycoprotein. A specific coding region of 795 bp within the viral spike (S) gene was amplified from 19 patients who suffered from obvious symptoms of SARS-CoV-2 infection. Sequencing results identified fifteen novel nucleic acid variations with a variety of distributions within the investigated samples. The electropherograms of all the identified variations showed obvious co-infections with at least two different viral strains per sample. Within these co-infections, the majority of samples exhibited three nonsense single nucleotide polymorphism (SNP)s, p.301Cdel, p.380Ydel, and p.436del, which yielded three truncated SARS-CoV-2 spike glycoproteins of 301, 380, and 436 amino acids length, respectively. The network and phylogenetic analyses indicated that for all viral infections were derived from multi-ancestral origins. Results inferred from the specific clade-based tree entailed that some viral strains were derived from European G-clade sequences. In conclusion, our data demonstrated the absence of any single strain infection among all investigated viral samples in the studied area, which may entail a higher risk of SARS-CoV-2 in this country. Through the identified high frequency of truncated spike proteins, we suggest that defective SARS-CoV-2 may depend on helper strains having intact spikes in its infection. Alternatively, another putative ACE2-independent route of viral infection way also suggested. To the best of our knowledge, this is the first report to describe the co-infection of multiple strains of SARS-CoV-2 in patients with COVID-19.

Preprint REVIEW | doi:10.20944/preprints201611.0101.v1

Forest Protected Area Systems and Biodiversity Conservation in Bangladesh

Sharif Ahmed Mukul, A. Z. M. Manzoor Rashid, Niaz Ahmed Khan

Subject: Environmental And Earth Sciences, Environmental Science Keywords: biodiversity conservation, livelihood, co-management, stakeholder, law enforcement

Online: 18 November 2016 (15:20:07 CET)

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Preprint OPINION | doi:10.3390/sci2030057

Global Significance of Mangrove Blue Carbon in Climate Change Mitigation (Version 1)

Daniel Alongi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: blue carbon; carbon; carbon stock; carbon sequestration; climate change; CO₂ emissions; mangrove; mitigation

Online: 23 July 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201605.0003.v1

Poly(lactide-co-glycolide)/Hydroxyapatite Porous Scaffold with Microchannels for Bone Regeneration

Ning Zhang, Yang Wang, Wenpeng Xu, Yong Hu, Jianxun Ding

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: poly(lactide-co-glycolide); hydroxyapatite; porous scaffold; microchannel; cell ingrowth; mass exchange; bone tissue engineering

Online: 27 May 2016 (11:25:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0169.v1

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Liudmyla Lazarenko, O. Melnikova, Lidiia Babenko, Rostyslav Bubnov, Tetiana Beregova, Tetiana Falalyeyeva, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: metabolic syndrome; diabetes mellitus; obesity, lactobacilli; bifidobacteria; glucose; macrophages; inflammation; mouse model

Online: 8 August 2018 (14:27:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0123.v1

Shifting Paradigm of Governance in the Natural Resources Management of Bangladesh: A Centralist to Pluralistic Approach in the Forest Protected Areas Management

A. Z. M. Manzoor Rashid, Donna Craig, Sharif Ahmed Mukul

Subject: Biology And Life Sciences, Forestry Keywords: co-management; livelihoods; conflicts; biodiversity conservation; sustainable development

Online: 24 November 2016 (11:25:34 CET)

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Good governance in natural resource management (NRM) is one of the most challenging issues in developing countries that often inappropriately embedded in national policies and political agendas. It is, in fact, even more important for countries like Bangladesh with exceptionally high pressure and dependence on its natural resources for sustaining rural livelihoods. Globally, nowadays, good governance is considered as one of the key factor for achieving the goal of sustainable development and biodiversity conservation. Bangladesh, of late has responded to that global zeal by involving local communities in the management of country’s declining forest and other natural resources. The colonial legacy of the forestry sector of Bangladesh was planned and, managed as interim projects through donors’ prescriptions. Thus, institutions, management processes and conservation outcomes were problematic. The conventional approach adopted by colonial and post-colonial regimes for forest management also proved to be inefficient due to its top-down management system. The absolute dependency on donor support, and their prescription sometimes worsened the situation both ecologically and socially. Global, regional and local trends supported the need for a different dimension in the governance paradigms. The introduction of a pluralistic approach, known as co-management in protected areas (PAs) is an example of an attempt whereby shared governance mechanism are implemented to attain the desired goals of conservation that will also address the livelihoods and aspirations of communities living in and around PAs of the country. However, in designing future forest and PA regimes the concern of the external aid support and attached conditions remain a reality that needs to be addressed. Adequate attention should be given to our vanishing biodiversity, culture and community livelihoods through devising an appropriate governance mechanism recognizing and supporting local rights, access and participation in the environmental management. It is now time to mainstream the adhoc nature of governance according to our national conservation strategy and policy frameworks in order to achieve the goals and objectives of the Bangladesh NRM sector addressing the human and community right of people in the specific context of forest protected areas management.

Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0149.v1

Social License to Operate and Adaptive Co-Marketing: Exchange, Social Capital and Community-Based Social Marketing

Colin Michael Hall, Helena Power

Subject: Business, Economics And Management, Marketing Keywords: adaptive co-marketing; social marketing; community-based social marketing; social license to operate; community engagement; corporate social responsibility; marketing strategy

Online: 30 November 2016 (05:13:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0252.v1

Immunophenotyping of Circulating Leukocytes Reveal Non-specific Activation of Innate and Adaptive Immune Systems in Multi-System Inflammatory Syndrome of Childhood Temporally Associated with SARS-Cov-2 Infection: Descriptive Cohort Study

Michael J. Carter, Matthew Fish, Aislinn Jennings, Katie J. Doores, Paul Wellman, Jeffrey Seow, Sam Acors, Emma Timms, Julia Kenny, Stuart Neil, Michael H. Malim, Shane M. Tibby, Manu Shankar-Hari

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-Co-V2; Paediatric hyperinflammation; MIS-C; PIMS-TS

Online: 12 July 2020 (12:09:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0124.v1

Pathogen Species Identification from Metagenomes in Ancient Remains: the Challenge of Identifying Human Pathogenic Species of Trypanosomatidae Via Bioinformatic Tools

Denis Sereno, Franck Dorkeld, Mohammad Akhoundi, Pascale Perrin

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Trypanosomatidae; Kraken taxonomic assignment tool; Bowtie2 fast short reads aligner; Ancient DNA; Parasitome; Co-infection

Online: 6 July 2018 (16:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0019.v1

The BCC/B2 Morphologies in AlxNiCoFeCr High-Entropy Alloys

Yue Ma, Beibei Jiang, Chunling Li, Qing Wang, Chuang Dong, Peter K Liaw, Fen Xu, Lixian Sun

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: high-entropy alloys; Al-Ni-Co-Fe-Cr alloys; microstructure; precipitation morphology; mechanical property

Online: 4 January 2017 (10:30:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0425.v1

Obstructive Sleep Apnea as a Cause of Gout

Burton Abrams, Peter Delannoy, Richard Johnson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: sleep apnea; hypoxia; gout; hyperuricemia; urate; metabolic comorbidities

Online: 24 February 2023 (09:31:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0442.v1

Observed and Potential Environmental Impacts of COVID -19 in Africa

Nyarai Mupatsi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: COVID-19, SARS-Co-V-2, Environment, Africa, Pandemic,Pollution

Online: 20 August 2020 (07:42:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0224.v2

Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha

Julia Sperlich, Nicole Teusch

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: pseudopterosin; triple negative breast cancer; glucocorticoid receptor alpha; dexamethasone; cell proliferation; 3D invasion; tumor spheroid; co-culture; interleukin 6; interleukin 8

Online: 2 August 2018 (06:08:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0027.v1

(T,N) and Residual Fuzzy Co-Implication in Dual Heyting Algebra with Applications

Iqbal H. Jebril

Subject: Computer Science And Mathematics, Analysis Keywords: Fuzzy implications; (S,N) implication; residuum t-norm; (T,N) co-implication; residual co-implication

Online: 3 August 2016 (08:29:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0217.v1

Medical Basis for Increased Susceptibility of COVID-19 among the Navajo and other Indigenous Tribes

Joseph De Soto, Shazia Hakim

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Indigenous Tribes; Co-morbidities; Corona Virus; Navaho

Online: 14 April 2020 (08:43:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0019.v1

“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling

Marietta Kokla, Anton Klåvus, Stefania Noerman, Ville M. Koistinen, Marjo Tuomainen, Iman Zarei, Topi Meuronen, Merja R. Häkkinen, Soile Rummukainen, Ambrin Farizah Babu, Taisa Sallinen, Olli Kärkkäinen, Jussi Paananen, David Broadhurst, Carl Brunius, Kati Hanhineva

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; LC-MS; mass spectrometry; metabolic profiling; computational; statistical; unsupervised learning; supervised learning; pathway analysis

Online: 3 February 2020 (05:54:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0083.v1

UPEI-400, a Conjugate of Lipoic Acid and Scopoletin, Mediates Neuroprotection in a Rat Model of Ischemia/Reperfusion

Barry J. Connell, Monique C. Saleh, Desikan Rajagopal, Tarek M. Saleh

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: stroke; antioxidant; co-drug; animal model

Online: 20 October 2016 (08:46:38 CEST)

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Background: Previously, our laboratory has provided evidence that pre-administration of the antioxidant, lipoic acid covalently bonded to various naturally occurring antioxidants, enhanced neuroprotective capacity compared to the administration of lipoic acid on its own. The naturally occurring compound scopoletin, a coumarin derivative, has been shown in various in vitro studies to have both antioxidant and anti-inflammatory mechanism of actions. To date, the effect of scopoletin on neuronal cell death in an in vivo model of ischemia or ischemia-reperfusion has not been investigated. Therefore, the present investigation was designed to determine if scopoletin on its own, or a co-drug consisting of lipoic acid and scopoletin covalent bond, named UPEI-400, would be capable of demonstrating a similar neuroprotective efficacy. Methods: Using a rodent model of stroke in male rats (anesthetized with Inactin®; 100 mg/kg, iv), the middle cerebral artery was permanently occluded for 6 hours (pMCAO), or in separate animals, occluded for 30 min followed by 5.5 hrs of reperfusion (ischemia/reperfusion; I/R). Results: Pre-administration of either scopoletin or UPEI-400 significantly decreased infarct volume in the I/R model (p<0.05), but not in the pMCAO model of stroke. However, UPEI-400 was ~1000 times more potent as compared to scopoletin on its own. The optimal dose of UPEI-400 was then injected during the occlusion and at several time points during reperfusion and significant neuroprotection was observed for up to 150 mins following the start of reperfusion (p<0.05). Conclusion: The data suggest that synthetic combination of scopoletin with lipoic acid (UPEI-400) is a more effective neuroprotectant that either compound on their own. Also, since UPEI-400 was only effective in a model of I/R, it is possible that it may act to enhance neuronal antioxidant capacity and/or upregulate anti-inflammatory pathways to prevent the neuronal cell death.

Preprint ARTICLE | doi:10.20944/preprints201707.0044.v1

A Comprehensive Technological Survey on Dependable Self-Managing CPS: The Decade of Researches on Correctness and Dependability

Peng Zhou, Kunmean HOU, Zhan Zhang, Decheng Zuo, Jian Dong, Jianjin Li, Haiyin Zhou

Subject: Engineering, Control And Systems Engineering Keywords: cyber physical systems; industry 4.0; MDE; hardware and software co-design; lifetime verification & validation; dependability; correctness; flexibility; self-management; self-adapting; self-healing

Online: 17 July 2017 (10:27:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0393.v1

Virtual Screening and Molecular Dynamics Simulation Suggest Valproic Acid Co-A could Bind to SARS-CoV2 RNA Depended RNA Polymerase

Neel Sarovar Bhavesh, Anupam Patra

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV2; RNA depended RNA polymerase; Valproic acid Co-A; drug repurposing

Online: 26 March 2020 (15:04:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0132.v1

Geography of Food Consumption Patterns between South and North China

Fangfang Song, Mi Sook Cho

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chinese adults; north region; south region; dietary pattern; metabolic syndrome

Online: 31 October 2016 (02:51:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0014.v1

An Elaborated Study of CO Sensitivities of Cu, Pt and Pd Activated SnO₂ Sensors: Effect of Precipitation Agents, Dopants and Doping Methods

Venkata Krishna Karthik Tangirala, Heberto Gomez-Pozos, Ventura Rodríguez-Lugo, María De La Luz Olvera

Subject: Chemistry And Materials Science, Nanotechnology Keywords: tin oxide pellets; doping; HRTEM analysis; CO; sensitivity

Online: 4 April 2017 (08:16:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0094.v1

Fast Preparation of Porous MnO/C Microspheres as Anode Materials for Lithium-Ion Batteries

Jing Su, Hao Liang, Xian-Nian Gong, Xiao-Yan Lv, Yun-Fei Long, Yan-Xuan Wen

Subject: Chemistry And Materials Science, Nanotechnology Keywords: lithium-ion batteries; anode materials; MnO; co-precipitation; T-shaped microchannel reactor

Online: 11 May 2017 (07:49:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0211.v2

HIV-1: Tackling the Obstacles that Limit the Effectiveness of CRISPR-Cas9 Gene Editing of the T Cell Co-receptor CCR5

Tatiana Hillman

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HIV-1; CRISPR-Cas9; T-cells; lipid nanoparticles; gut-associated-lymphoid tissue; Co-receptors; Probiotics; GI Tract,; Gene Editing

Online: 13 April 2020 (10:57:52 CEST)

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HIV-1 is a complicated and perplexing virus. It infects T cells, reverse transcribes its RNA into DNA, utilizes its host DNA machinery to replicate its HIV-DNA, translates the HIV-DNA into proteins, assembles itself for a budding escape from the T cell, and rapidly mutates its conformation. Partially, due to its complexity, there remains no cure for HIV or AIDs. However, recently with the discovery of TALENs, the use of zinc fingers, and most of all the applications of CRISPR-Cas9 technology, has given researchers new hope in finding alternative gene therapies and treatments for diseases. With more focus on CRISPR-Cas9, this new and novel technology uses a guiding RNA, sgRNA, to lead a Cas9 nuclease to its target for deletion or to change that DNA site. CRISPR-Cas9 can delete point mutations and multiple DNA sites. Because CRISPR can alter DNA sequences, several scientists have conducted research into CRISPR, possibly treating more diseases such as cancer, diabetes, and even HIV. HIV-1 drew the focus of a researcher named Dr. Ebina in 2013 when he was the first to design and apply CRISPR-Cas9 to genes found in the binding sites of HIV-1, inhibiting HIV-1 gene expression. Since 2013, several other researchers have blocked HIV replication and infection through CRISPR-Cas9 targeting the receptors of T cells called the CC chemokine receptor 5 or CCR5. HIV-1 binds to the CD4 receptor of T cells, which consists of co-receptors CCR5 and CXCR4. If CCR5 expression can be removed, the HIV virus cannot bind to T-cells, blocking the initial attachment stage, and discontinuing the infection. However, there remain obstacles and issues for the CRISPR deletion of CCR5 for treating HIV-1. The issues include: 1) finding new and safe methods of CRISPR-Cas9 delivery, 2) clearing the latent HIV reservoirs, 3) improving the sgRNA design to avoid off-target mutations or deletions, and 4) effectively analyze the viral escape of HIV from CRISPR-Cas9 modifications. Therefore, the purpose of this review is to discuss possible techniques for removing the obstacles that can lessen the potential of CRISPR to delete CCR5, repressing HIV-1 into long-term remission or a functional cure.

Preprint CONCEPT PAPER | doi:10.20944/preprints201702.0053.v1

Market Spread an Indicator of Systemic Risk in India

Subhash Karmakar, Gautam Bandyopadhyay

Subject: Business, Economics And Management, Finance Keywords: Systemic risk; Systemically Important Firms(SIFs); Stock Price; Stock Price (Close); Stock Price (Open); Stock Price: Bid; Stock Price: Ask; Stock Price: Spread; Joint Probability of Distress(JPoD); Banking Stability Index (BSI); Co-Risk Model

Online: 15 February 2017 (10:40:33 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202204.0185.v3

How Risky if China Moves Away from Its Zero-COVID Policy?

Ji-Ming Chen, Guo-Hui Li, Yu-Fei Ji, Ming-Hui Sun, Huan-Yu Gong, Rui-Xu Chen, Ji-Wang Chen

Subject: Public Health And Healthcare, Health Policy And Services Keywords: case fatality rate; co-infection; control; COVID-19; pandemic; policy; risk; vaccination

Online: 6 May 2022 (03:38:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0048.v1

Increased Corticospinal Excitability and Muscular Activity in a Lower Limb Reaction Task under Psychological Pressure

Yoshifumi Tanaka, Tatsunori Shimo

Subject: Social Sciences, Behavior Sciences Keywords: stress; transcranial magnetic stimulation; spinal reflex; reaction time; co-contraction

Online: 10 April 2017 (05:59:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0014.v1

Co-simulation Framework for on-Chip LIDAR Sensors in a Cyber-physical System

Fernando Castaño, Gerardo Beruvides, Rodolfo E. Haber, Antonio Artuñedo

Subject: Physical Sciences, Mathematical Physics Keywords: sensor-in-the-loop; co-simulation framework; virtual CPS; on-chip LiDAR; obstacle recognition library

Online: 4 August 2017 (14:13:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0197.v1

Co-integration and Causality Analysis of Carbon Intensity and Coal Consumption of China

Xing Wang, Zhongqi Fan, Ying Zhang

Subject: Engineering, Energy And Fuel Technology Keywords: carbon intensity; coal consumption; co-integration test; Granger causality; error correction model

Online: 27 March 2017 (10:33:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0121.v1

Molecular interactions of autophagy with the immune system and cancer

Yonggeun Hong, Yunho Jin, Yunkyung Hong, Chanyoung Park

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: autophagy； immune system； cancer；cell death；metabolic homeostasis

Online: 27 June 2017 (06:30:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint REVIEW | doi:10.20944/preprints201704.0171.v1

Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic Mice

Sohsuke Yamada, Xin Guo, Akihide Tanimoto

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Peroxiredoxin (PRDX) 4, chronic inflammatory disease, metabolic syndrome, human PRDX4 transgenic mice (Tg), animal model.

Online: 26 April 2017 (17:57:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0124.v1

Assessing and Resolving Model Misspecifications in Metabolic Flux Analysis

Rudiyanto Gunawan, Sandro Hutter

Subject: Engineering, Bioengineering Keywords: metabolic flux analysis, model misspecification, constraint-based model, stoichiometric model, Chinese hamster ovary cell culture

Online: 16 March 2017 (17:38:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201803.0064.v2

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

Marit K. Zinöcker, Inge A. Lindseth

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: western diet; microbiome; food processing; inflammation; metabolic diasease

Online: 19 March 2018 (07:31:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201804.0359.v1

Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses

Teresa Nguyen, Naze G. Avci, Dong Ho Shin, Naiara Martinez-Velez, Hong Jiang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: oncolytic virus; in situ autovaccination; cytokine; immune checkpoint inhibitor; immune co-stimulator

Online: 27 April 2018 (09:18:37 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201905.0078.v1

Derivations of the Core Functions of the Maximum Entropy Theory of Ecology

Alexander Brummer, Erica Newman

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: information entropy, information theoretics, macroecology, metabolic theory, scaling, species abundance distribution, species-area relationship

Online: 7 May 2019 (11:24:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0185.v1

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Rostyslav Bubnov, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: predictive preventive personalized medicine; Lactobacillus; Bifidobacterium; probiotics, gut microbiota; patient phenotype, individualized medicine; metabolic syndrome

Online: 11 September 2018 (06:00:03 CEST)

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The modification the gut microbiota in metabolic syndrome and associated chronic diseases is among leading tasks of microbiome research and needs for clinical use of probiotics. Evidence lack for the implications for microbiome modification to improve metabolic health in particular when applied impersonalized. Probiotics have tremendous potential in personalized nutrition and medicine to develop healthy diets. The aim was to to conduct comprehensive overview of recent updates of role of microbiota on human health and development of metabolic syndrome and efficacy of microbiota modulation considering specific properties of probiotic strain and particular aspects of metabolic syndrome and patient`s phenotype to fill the gap between probiotic product and individual to facilitate development of individualized / personalized probiotic and prebiotic treatments. We discuss the relevance of using host phenotype-associated biomarkers, those based on imaging and molecular and patrient`s history, reliable and accessible to facilitate person-specific appication of probiotics and prebiotic substances. Microbiome phenotypes can be parameters of predictive medicine to recognize patient`s predispositions and evaluate treatment responses; the number of phenotype markers can be effectively involved to monitor microbiome modulation. The studied strain-dependent properties of probiotic strains are potentially relevant for individualized treatment for gut and distant sites microbiome modulation. The evidence regarding probiotic strains properties can be taken to account via pathophysiology-based approach for most effective individualized treatment via gut, oral and vaginal and other sites microbiome modulation according to phenotype of the patient providing individualized and personalized medical approaches. Preventive potential of probiotics is strong and well-documented. Recommendations for individualized clinical use of probiotics, and for probiotic studies design have been suggested.

Preprint ARTICLE | doi:10.20944/preprints201807.0367.v1

Metformin Hydrochloride-Plga Nanoparticles in Diabetic Rats in A Periodontal Disease Experimental Model

Aline de Sousa Barbosa Freitas Pereira, Gerly Anne de Castro Brito, Maria Laura de Souza Lima, Arnóbio Antônio da Silva Júnior, Emanuell dos Santos Silva, Adriana Augusto de Rezende, Raul Hernandes Bortolin, Maria Galvan, Flavia Q. Pirih, Raimundo Fernandes de Araújo Júnior, Caroline Addison Carvalho Xavier de Medeiros, Gerlane Coelho Bernando Guerra, Aurigena Antunes de Araújo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: nanoparticles; poly lactic-co-glycolic acid; metformin; periodontal disease; inflammation

Online: 20 July 2018 (03:40:29 CEST)

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The aim of this study was synthesize and evaluate the effects of Poly (D, L-Lactide-co-glycolide) (PLGA) Nanoparticles (NPs) of metformin (PLGA+ Met) on inflammation, and bone loss in a ligature-induced periodontitis rat model. The prepared NPs were characterized by mean diameter, size particle, polydispensity index and encapsulation efficiency by Atomic force microscopy (AFM). Male albino Wistar rats were randomly divided into four groups of 20 rats in each group, and given the following treatments for 10 days to evaluate in vivo activity: (1) Sham: no ligature + water; (2) Positive control: ligature + water (with Periodontal disease and Diabetes); (3) ligature + PLGA+ 10 mg/kg Met (With Periodontal disease and Diabetes); and (4) ligature + PLGA+ 100 mg/kg Met (with Periodontal disease and Diabetes). Water or PLGA + Met was administered orally by gavage. Maxillae were fixed and scanned using Micro-computed Tomography (μCT) to quantify linear of bone loss. Histopathological characteristics were assessed through immunohistochemical staining for Osteocalcin, Cathepsyn K, RANKL/RANK/OPG pathway. IL-1β and TNF-α from gingival tissues were analysed by Elisa immunoassay. Quantitative RT-PCR reaction was used to evaluate gene expression of AMPK, NF-κB p-65, Hmgb1 and TAK-1 from gingival tissues. Statistical analysis was performed using one-way ANOVA at 5% significance. The mean diameter of MET-loaded PLGA nanoparticles was in a range of 457.1 ± 48.9 nm with a polydispersity index of 0.285, zeta potential: 8.16 ± 1.1 mV and entrapment efficiency (EE) was 70%. The results suggest that the addition of MET in the core slightly affected the particle sizes. Treatment with PLGA+ 10 mg/kg Met showed low inflammatory cells, decreased bone loss and integrity cement and levels of IL-1β, and TNF-α (p < 0.05) were significantly reduced. Additionally, weak staining was shown by RANKL, Cathepsyn K, OPG, and osteocalcin. Radiographically, linear measurements showed a statistically significant reduction in bone loss after treatment with PLGA+ 10 mg/kg Met compared to the positive control (p < 0.05). RT-PCR showed increased AMPK expression (p < 0.05) and decreased expression of NF-κB P65, HMGB1 and TAK-1 after PLGA+ 10 mg/kg Met (p < 0.05). The PLGA nanoparticle + 10 mg/kg Met decreased glucose levels and also decreased the inflammatory response, and bone loss in ligature-induced periodontitis in rats.

Preprint ARTICLE | doi:10.20944/preprints201804.0049.v1

Mangosteen Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study

Mikiko Watanabe, Elena Gangitano, Davide Francomano, Eliana Addessi, Raffaella Toscano, Daniela Costantini, Dario Tuccinardi, Stefania Mariani, Sabrina Basciani, Giovanni Spera, Lucio Gnessi, Carla Lubrano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: garcinia mangostana; inflammation; insulin resistance; metabolic syndrome; diabetes; xanthones; mangostin; phytotherapy; dietary supplements

Online: 4 April 2018 (06:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0078.v1

Factors Influencing the Production of Different Types of Fatty Acid and Staphyloxanthin in the Staphylococcus aureus Membrane

Kiran Tiwari, Craig Gatto, Brian J. Wilkinson

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: membrane fatty acids composition; Staphylococcus aureus; staphyloxanthin; membrane fluidity; metabolic regulation

Online: 6 April 2018 (11:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0210.v1

Intestinal Microbial and Metabolite Profiling of Mice Fed with Dietary Glucose and Fructose

João C. P. Silva, Marta Mota, Fátima O. Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S. Barros, John G. Jones, Ana M. Gil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: fructose; intestinal microbiota; short-chain fatty acids; metabolic profiling

Online: 23 January 2018 (05:31:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0182.v1

COVID-19 and Crosstalk between the Hallmarks of Aging

Shabnam Salimi, John M. Hamlyn

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; pandemic; co-morbidity; aging; hallmarks of aging; anti-aging

Online: 12 April 2020 (04:52:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0322.v1

Crotoxin-Treated Macrophages Stimulate ROS Production and Killing Activity in Co-Cultured Neutrophils

Renata Begliomini Bruno De-Oliveira, Ellen Emi Kato, Tatiane Soares de Lima, Tatiana Carolina Alba-Loureiro, Rui Curi, Maria Cristina Cirillo, Sandra Coccuzzo Sampaio

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: crotoxin; macrophages; neutrophils; inflammation; ATP; reactive oxygen and nitrogen species; cytokines; co-culture model

Online: 23 May 2018 (09:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0137.v1

Electrode Cooling Effect on Out-of-Phase Electrothermal Streaming in Rotating Electric Fields

Weiyu Liu, Yukun Ren, Ye Tao, Xiaoming Chen, Qisheng Wu

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: electrothermal flow; rotating electric field; out-of-phase smeared structural polarization; electrode cooling; external natural convection; co-field flow rotation

Online: 27 September 2017 (12:11:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0010.v1

Thermoelectric Properties of Bi₂Te₃: CuI and the Effect of Its Doping with Pb Atoms

Mi-Kyung Han, Yingshi Jin, Da-Hee Lee, Sung-Jin Kim

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: Bi2Te3; Thermoelectric properties; co-doping; n-type

Online: 2 October 2017 (15:33:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0081.v1

Insulin Resistance Syndrome- the Sensitive IRS

Eleni Pellazgu

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: insulin resistance; diet; exercise; microbiome; metabolic disorders

Online: 9 January 2018 (10:05:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0551.v1

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Zahraa Al Wadee, Soo Liang Ooi, Sok Cheon Pak

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Obstructive sleep apnoea; intermittent airway obstruction; sleep disorder; magnesium; micronutrient deficiency; metabolic risk factor

Online: 30 August 2021 (15:47:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0055.v1

The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST)

Lisa Te Morenga, Paul Docherty, Sheila Williams, Jim Mann

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diet; dietary protein; dietary fibre; insulin sensitivity assessment; insulin sensitivity; insulin resistance; metabolic syndrome

Online: 8 November 2017 (16:20:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0089.v1

The Relative Influence of Inter-Generational Co-Residence on Healthcare Market and Labor Market Outcomes in Post Affordable-Care-Act USA: Evidence from the 2015–2016 National Health Interview Surveys

Ibrahim Niankara

Subject: Business, Economics And Management, Economics Keywords: Affordable Care Act; access to care; co-residence; labor supply; medical expenditure

Online: 12 March 2018 (08:36:46 CET)

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This paper investigates the effects of Inter-generational co-residence on health care market, and labor market outcomes, to see whether or not living under the same roof with at least one parent matters in health care market, and labor market behaviors in post-Affordable-Care Act (ACA) USA. The adopted analytical strategy involves not only looking at the gender differences in co-residence, and its effects on outcomes in the two markets, but also accounting for co-residence endogeneity following the recent literature. Unlike the recent literature that relies on instrumental variables methods, this study adopts a switching regression approach, defining inter-generational co-residence as an endogenous selection process using a binary probit equation, and modeled jointly with the extensive margins and intensive margins in the two markets. This novel approach results in a recursive trivariate probit model for each market, and estimated using penalized maximum likelihood methods. The results suggest that ACA by reorganizing the US health care market, seems to have reduced significantly disparities in health care access among males and females based on race, region of residence, place of birth, and citizenship. However not only do we observe significant differences in inter-generational co-residence status between males and females, we also find significant inequalities in the effects of co-residence on health care market, and labor market outcomes. In fact, co-residence is found to increase health care expenditure by 56.7% among females, while this figure increases to 74.2% among males. In addition co-residing individuals, while spending 69.7% more on health care annually are 1.22 times more likely to access health care, but 31% less likely to use health care intensively during the year. In the labor market, co-residence is found to reduce significantly hours of weekly labor supplied by 41% for females, and 55.6% for males. Furthermore co-residing individuals, while not significantly different in their likelihood of labor force participation, are 1.52 times less likely to work full time once they decide to participate, and also spend about 55.4% less time working in the labor market in post-ACA USA.

Preprint ARTICLE | doi:10.20944/preprints202108.0197.v1

Why IEEE Xplore Matters for Research Trend Analysis in the Energy Sector

Boris Chigarev

Subject: Engineering, Electrical And Electronic Engineering Keywords: bibliometric analysis, IEEE Xplore, INSPEC Controlled Terms, keywords co-occurrence, research trends, Scopus

Online: 9 August 2021 (12:53:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints201910.0064.v1

Metabolic Reprogramming and Its Role in Plant Cold Acclimation

Lisa Fürtauer, Jakob Weiszmann, Wolfram Weckwerth, Thomas Nägele

Subject: Biology And Life Sciences, Plant Sciences Keywords: cold acclimation; metabolic reprogramming; carbohydrates; subcellular metabolism; sucrose cycling; enzyme activity; arrhenius equation; kinetic modelling; arabidopsis thaliana

Online: 7 October 2019 (11:19:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0059.v1

Data Normalization in NMR-based Metabolomics

Helena Zacharias, Michael Altenbuchinger, Wolfram Gronwald

Subject: Biology And Life Sciences, Biophysics Keywords: data normalization; data scaling; zero-sum; metabolic fingerprinting; NMR; statistical data analysis

Online: 3 July 2018 (16:22:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0265.v2

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Melvin Hayden

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Aging; Alzheimer’s disease; brain insulin resistance; db/db diabetic mouse model; diabetic cognopathy; insulin resistance; metabolic syndrome; mixed dementia; obesity; type 2 diabetes mellitus

Online: 9 September 2019 (06:12:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0342.v1

Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis

Ifan Ali Wafa, Nando Reza Pratama, Nurizzah Farahiyah Sofia, Elsha Stephanie Anastasia, Tiffany Konstantin, Maharani Ayuputeri Wijaya, M. Rifqi Wiyono, Lilik Djuari, Hermina Novida

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 lockdown; diabetes mellitus; meta-analysis; metabolic control; systematic review

Online: 14 June 2021 (09:44:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0026.v2

A Review and Scientometric Analysis of Global Building Information Modelling (BIM) Research in the Architecture, Engineering and Construction (AEC) Industry

Ziwen Liu, Yujie Lu, Lu Chang Peh

Subject: Engineering, Civil Engineering Keywords: building information modelling; co-citation network; literature review; research visualization; scientometrics

Online: 9 July 2019 (03:42:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0177.v1

Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice

Gábor Somlyai, Lajos I. Nagy, László G. Puskás, András Papp, Beáta Zs. Kovács, István Fórizs, György Czuppon, Ildikó Somlyai

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet

Online: 13 June 2022 (09:49:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0220.v1

Genetic Optimization Algorithm for Metabolic Engineering Revisited

Tobias B. Alter, Lars M. Blank, Birgitta E. Ebert

Subject: Engineering, Bioengineering Keywords: metabolic strain design; heuristic optimization; constraint-based modeling

Online: 27 March 2018 (05:55:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0035.v1

An Econometric Analysis of ETF and ETF Futures in Financial and Energy Markets Using Generated Regressors

Chia-Lin Chang, Michael McAleer, Chien-Hsun Wang

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: exchange traded funds; financial and energy sectors; co-volatility spillovers; spot and futures prices; generated regressors; Diagonal BEKK

Online: 11 September 2017 (04:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0190.v1

Mast Cells Interact with Endothelial Cells to Accelerate In Vitro Angiogenesis

Devandir Antonio de Souza Junior, Vivian Marino Mazucato, Ana Carolina Santana, Constance Oliver, Maria Celia Jamur

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: mast cells; angiogenesis; endothelial cells; tube formation assay; co-culture; gap junction

Online: 31 October 2017 (03:51:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0124.v1

Development of a Food-Based Index of Dietary Inflammatory Potential for Koreans and Its Relationship with Metabolic Syndrome

Woori Na, Tae Yang Yu, Cheongmin Sohn

Subject: Biology And Life Sciences, Food Science And Technology Keywords: metabolic syndrome; inflammation; index; Korea

Online: 10 April 2018 (09:50:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0021.v1

Study of White-rot Fungus Immobilization on Leather Dye Wastewater Treatment

Shan Cao, Xudong Xu, Deyi Zhu, Changhua Jiang, Tianping Yu, Yanchun Li

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: White rot fungus; Co-immobilization; Dye wastewater treatment; Dye decolorisation; Acid golden yellow dye

Online: 4 March 2019 (09:04:40 CET)

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The dye effluent is usually difficult to be degraded by conventional wastewater treatment in leather industry. In order to develop efficient and cost-effective treatment methods, we evaluate the effect of white-rot fungus immobilization for dye decolorisation in this paper. The Phanerochaete chrysosporium BKM-F-1767 was used for immobilization. This research found that the white-rot fungus immobilization had an obviously decolorisation effect in dye wastewater treatment, and plant carriers such as sorghum stalk and corn cob were helpful to the growth of Phanerochaete chrysosporium in white-rot fungus immobilization. Due to the stability and recyclability, the white-rot fungus co-immobilization was considered as the most suitable treatment for decolorisation of dye effluent which enjoyed the advantages of both adsorption immobilization and entrapment immobilization. Furthermore, the dye decolorisation evaluation was carried out to find the most suitable carrier for co-immobilization, and it found that sorghum stalk - calcium-alginate gel spherical particle (SS-CGPB) has better decolorisation effect than corn cobs - calcium-alginate gel spherical particle (CC-CGPB), and the dye decolorisation rate was 86.77%. After 5 cycles, the dye decolorisation rate was 85.87% which indicated the SS-CGPB preserved functional integrity successfully. By further analyzing the biodegradation process with white-rot fungus immobilization, the intermediate products were observed and the degradation pathway of acid golden yellow dye molecular was proposed. The results showed that the C-N single bonds attached to the central benzene in the dye molecule were attacked and destroyed in white-rot fungus co-immobilization treatment, thus the structure of dye molecule could be successfully degraded into small molecules which would be more easily treated by conventional treatment methods. Therefore, the white rot fungus co-immobilization might be appropriate for pre-treatment as an important biotechnology for the advanced treatment of dye effluent.

Preprint ARTICLE | doi:10.20944/preprints201710.0164.v1

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome

Pedram Shokouh, Per Bendix Jeppesen, Kjeld Hermansen, Natalja Nørskov, Christoffer Laustsen, Stephen Jacques Hamilton-Dutoit, Haiyun Qi, Hans Stødkilde-Jørgensen, Søren Gregersen

Subject: Biology And Life Sciences, Food Science And Technology Keywords: coffee; dietary supplements; metabolic syndrome X; non-alcoholic fatty liver disease; adiponectin; hyperpolarized magnetic resonance spectroscopy

Online: 27 October 2017 (02:32:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0554.v1

Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function

Sk. Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Parise Adadi, Alaa Aljabali, Elrashdy Redwan, Amos Lal, Ramesh Kandimalla, Tarek El-Aziz, Pabitra Choudhury, Gajendra Azad, Samendra Sherchan, Murtaza Tambuwala, Gaurav Chauhan, Kazuo Takayama, Debmalya Barh, Giorgio Palù, Pallab Basu, Vladimir N Uversky

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; ORF10; Co-mutations; Intrinsic Protein Disorder; Ubiquitin Ligase Complex

Online: 26 July 2021 (09:07:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0272.v1

Metabolic Reprogramming, Meaning and Implications

Pierre Jacquet, Angélique Stéphanou

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Metabolic reprogramming; Warburg effect; Cancer metabolism

Online: 14 January 2021 (13:30:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0163.v1

Yarrowia lipolytica strains and their biotechnological applications: how natural biodiversity and metabolic engineering could contribute to cell factories improvement

Catherine Madzak

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: white biotechnology; metabolic engineering; non-conventional yeast; oleaginous yeast; cell factory; heterologous expression; biodiversity; Yarrowia lipolytica; Yarrowia clade; GMO

Online: 7 June 2021 (10:50:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0079.v1

The Importance of a Natural Social Contract and Co-Evolutionary Governance for Sustainability Transitions

Patrick Huntjens, René Kemp

Subject: Social Sciences, Political Science Keywords: Natural Social Contract; Co-evolutionary governance; Transformative governance; Institutional change; Policy mixes; Transformative Social-Ecological Innovation; Transformative Social Innovation; Social Innovation; Sustainability Transition; Societal Transition

Online: 7 February 2022 (11:43:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0165.v1

Greater Protection against Virulent Infectious Bronchitis Virus Challenge Conferred by Recombinant Baculovirus Co-expressing S1 and N Proteins

Yuan Yuan, Zhi-Peng Zhang, Yi-Ning He, Wen-Sheng Fan, Zhi-Hua Dong, Li-Hua Zhang, Xin-Kuan Sun, Li-Li Song, Tianchao Wei, Mei-Lan Mo, Ping Wei

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: infectious bronchitis virus; protection; co-expressing; subunit vaccine; challenge

Online: 10 May 2018 (12:02:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0084.v1

Dissolved Silica Effects on Adsorption and Co-Precipitation of Sb(III) and Sb(V) with Ferrihydrite

Shuang Zhou, Tsutomu Sato, Tsubasa Otake

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: antimony; ferrihydrite; silica; adsorption; co-precipitation

Online: 10 January 2018 (07:02:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0548.v1

Metabolic Modelling Approaches for Describing and Engineering Microbial Communities

Beatriz García-Jiménez, Jesús Torres, Juan Nogales

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: genome-scale metabolic model; microbial community; optimization; design; engineering; computational methods; synthetic microbial consortia

Online: 23 September 2020 (09:52:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0110.v1

An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii

Ashok Aspatwar, Susanna Haapanen, Seppo Parkkila

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: carbonic anhydrases; CA gene family; Chlamydomonas reinhardtii; model alga; metabolic role; photosynthesis

Online: 12 January 2018 (07:21:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0180.v1

Antagonistic Interactions between Benzo[a]pyrene and C₆₀ in Toxicological Response of Marine Mussels

Audrey Barranger, Laura M. Langan, Vikram Sharma, Graham A. Rance, Yann Aminot, Nicola J. Weston, Farida Akcha, Michael N. Moore, Volker M. Arlt, Andrei N. Khlobystov, James W. Readman, Awadhesh N. Jha

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Trojan Horse effect; B[a]P; nC60; co-exposure; Mussels; DNA damage; proteomics

Online: 15 May 2019 (09:57:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0227.v1

Converting Ensemble Clustering Problem to a Mathematical Optimization Problem and Providing an Approach to Solve Based on Optimization Toolbox

Simintaj Salehpour, Hamid Parvin

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Ensemble clustering; cluster stability; F-measure; co-association matrix; genetic algorithm

Online: 17 April 2018 (15:58:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0205.v1

Incorporating an Increase in Plant-Based Food Choices into a model of Culturally Responsive Care for Obesity in Hispanic/Latino Adults and Children

Pramil Singh, Jessica Steinbach, Anna Nelson, Wendy Shih, Mary D'Avila, Selene Castilla, Michael Jordan, William McCarthy, David Hayes Bautista, Hector Flores

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diabetes; vegetarian; diet; nutrition; metabolic syndrome; disparity; child

Online: 17 October 2019 (15:24:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0155.v1

Quality Assurance Framework Development Based on Six New ECV Data Products to Enhance User Confidence for Climate Applications

Joanne Nightingale, Folkert Boersma, Jan-Peter Muller, Steven Compernolle, Jean-Christopher Lambert, Simon Blessing, Ralf Giering, Nadine Gobron, Isabelle De Smedt, Pierre Coheur, Maya George, Jörg Schulz, Alex Wood

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: essential climate variables; climate data records; earth observation satellites; quality assurance; traceability; user requirements; climate applications; surface albedo; LAI; FAPAR; NO2; HCHO; CO

Online: 11 June 2018 (11:24:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0323.v2

Integrated Operational Logistics Network (IOLN) Design (Case Study: Iran Khodro Automotive Co)

Javad Khamisabadi, Mahmood Majd, Javad Shokoufeh Pour, Mohammad Reza Motamed, Seyed Ahmad Haji Khalili, Babak Rahmani

Subject: Engineering, Automotive Engineering Keywords: Logistics, Supply Chain, Integrated, Fuzzy Vikor, Network, Iran Khodro Co

Online: 26 June 2018 (15:07:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0724.v1

Enhanced Anticancer Activity of Nanoformulation of Dasatinib against Triple-Negative Breast Cancer by Reduced Metabolic Degradation

Fatemah Bahman, Valeria Pittalà, Mohamed Haider, Khaled Greish

Subject: Chemistry And Materials Science, Biomaterials Keywords: TNBC; dasatinib; poly(styrene-co-maleic acid) micelles; nanoformulation; metabolism; EPR; nanomedicine; targeted therapy.

Online: 27 April 2021 (13:56:12 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201811.0254.v1

Fatal Dengue, Chikungunya and Leptospirosis Co-Infection: The Febrile Patient in Tropical Areas, Importance of Co-Infection Assessment

Jaime A. Cardona-Ospina, Carlos E. Jimenez-Canizales, Heriberto Vasquez-Serna, Jesús Alberto Garzon-Ramirez, Jose Fair Alarcon-Robayo, Juan Alexander Cerón-Pineda, Alfonso J. Rodriguez-Morales

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: dengue; chikungunya; Leptospira; co-infection; Colombia; Latin America

Online: 12 November 2018 (03:21:38 CET)

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Preprint ESSAY | doi:10.20944/preprints202007.0440.v1

Application of Metabolic Engineering Approaches in Enhancing Biological Hydrogen Production

Wenfa Ng

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: metabolic engineering; biohydrogen production; microbes; co-culture; metabolic network analysis

Online: 19 July 2020 (20:43:36 CEST)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0244.v1

Curating and Comparing 114 Strain-Specific Genome-Scale Metabolic Models of Staphylococcus aureus

Alina Renz, Andreas Dräger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; MRSA; genome-scale metabolic models; model-driven discovery; strain-specific models

Online: 8 April 2021 (14:25:31 CEST)

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Working Paper ARTICLE

Promoting Exercise in Urban Area: Importance of Green Space and Facility Accessibility

John W.M. Yuen, Katherine K.P. Chang, Frances K.Y. Wong, Fiona Y. Wong, Judy J. Siu, H.C. Ho, M.S. Wong, Janice Y.S. Ho, K.L. Chan, Lin Yang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: physical activity; exercise; green cover; open space; Metabolic Equivalent of Task; International Physical Activity Questionnaire; health promotion

Online: 20 March 2019 (10:46:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0562.v1

In vitro 3D Model of Female Reproductive Tract: An Overview and Future Aspect

Arnaud Martino Capuzzo

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: female reproductive tract; organoid; co-culture; crosstalk; blastocyst

Online: 31 August 2021 (11:19:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0280.v1

A Mechanistic Model for Genome-Scale Estimations of Metabolic Activity

Cankut Cubuk, Carlos Loucera, Marta Hidalgo, Alicia Amadoz, Jose Carbonell-Caballero, María Peña-Chilet, Joaquin Dopazo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: metabolic pathways; mechanistic model; Transcriptomic

Online: 14 January 2021 (18:01:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0248.v1

Joint Transcriptome and Metabolome Analysis Prevails Biological Mechanisms Underlying the Prosurvival Fight in Heat Stressed Granulosa Cells

Abdul Sammad Sammad, Hanpeng Luo, Lirong Hu, Adnan Khan, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; integrated analysis; transcriptomics; metabolomics; differentially ex-pressed genes; metabolites; signaling pathways; metabolic pathways; cancer pathways

Online: 27 April 2022 (05:08:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0379.v1

Substrate-Induced Response in Biogas Process Performance and Microbial Community Relates Back to Inoculum Source

Tong Liu, Li Sun, Åke Nordberg, Anna Schnürer

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: anaerobic digestion; Co-digestion; CSTR; BMP-test; Illumina sequencing; T-RFLP; glycoside hydrolase families 5 and 48

Online: 27 May 2018 (12:53:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0228.v1

Co-Simulation of Smart Distribution Network Fault Management and Reconfiguration with LTE Communication

Michele Garau, Emilio Ghiani, Gianni Celli, Fabrizio Pilo, Sergio Corti

Subject: Engineering, Electrical And Electronic Engineering Keywords: smart grid, cyber physical co-simulation, information and communication technology, 4g long term evolution - lte, network reconfiguration, fault management

Online: 17 April 2018 (16:36:34 CEST)

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Working Paper ESSAY

Directional Protective Relaying Based on Amplitude Comparison of Traveling Wave on Continuous Co-phase AT Power Supply System by Using VMD

Shilong Chen, Xiaonan Yang, Yaoxi Jiang, Sihong Zhao

Subject: Engineering, Control And Systems Engineering Keywords: continuous co-phase traction power supply system (CCTPSS); traction electric network; directional protective relaying(dpr); amplitude comparison of traveling wave; VMD; modulus maximum

Online: 27 October 2019 (15:24:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0550.v1

Interdisciplinary Co-design Framework in Healthcare Design for Older Adult Patients with Chronic Low-back Pain

Muhammad Tufail, HaeBin Lee, Hwang Kim, KwanMyung Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Interdisciplinary co-design; healthcare design; exercise; low-back pain; older adult patients; rehabilitation

Online: 30 August 2021 (15:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0139.v1

A High-throughput Method for Fingerprinting of Rhizobial Free Fatty Acids by the Combination of a Thin Film Chemical Deposition Technique and Matrix-assisted Laser Desorption/ionization Time-of Flight Mass Spectrometry

Alexsey Gladchuk, Julia Schumilina, Alena Kusnetsova, Ksenia Bureiko, Alexander Tsarev, Irina Alexandrova, Larisa Leonova, Vladimir A. Zhukov, Igor A. Tikhonovich, Claudia Birkemeyer, Ekaterina Podolskaya, Andrej Frolov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bacteria; barium monocarboxylates; chemical deposition techniques; free fatty acids (FFAs); Langmuir film technology; matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS); metabolic fingerprinting; rhizobia

Online: 13 January 2020 (13:25:49 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202009.0701.v1

Risks of Simultaneous Co-Infection of Dengue and COVID-19 in Bangladesh: Challenges and Recommendations

Md. Sahidur Rahman, Tazrina Rahman

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Challenges; coinfection; COVID-19; dengue fever; co-epidemic; health care facility

Online: 29 September 2020 (09:12:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0315.v1

Prevalence of Metabolic Syndrome and Its Associated Factors among Vegetarians in Malaysia

Yuan Kei Ching, Yit Siew Chin, Mahenderan Appukutty, Wan Ying Gan, Vasudevan Ramanchadran, Yoke Mun Chan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: metabolic syndrome; vegetarian; vegetarianism practices; overweight; lifestyle behaviors

Online: 20 June 2018 (08:49:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0014.v1

Microbial Degradation of Pharmaceuticals

Swathi Kandhasamy, Sudha Balraj, Suganya Kanagaraj, Sumathi Sundaravadivelu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pharmaceutical toxicants; recalcitrant pollutants; co-metabolic pathways; biostimulation; bioaug-mentation

Online: 1 June 2022 (10:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0290.v3

New Workflow Predicts Drug Targets Against SARS-CoV-2 via Metabolic Changes in Infected Cells

Nantia Leonidou, Alina Renz, Reihaneh Mostolizadeh, Andreas Dräger

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: host-virus interactions; tissue-specific model; COVID-19; SARS-CoV-2; antiviral targets; flux balance analysis; flux variability analysis; reaction knockout; host-derived enforcement; metabolic modeling; virus mutations; software engineering; Python

Online: 17 January 2023 (01:50:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0397.v1

Numerical Simulation and Experimental Study of Capacitive Imaging Technique as a Non-Destructive Testing Method

Farima Abdollahi Mamoudan, Sebastien Savard, Tobin Filleter, Clemente Ibarra-Castanedo, Xavier Maldague

Subject: Engineering, Automotive Engineering Keywords: co-planar sensor; capacitive sensing; NDT techniques; FE modelling; defects

Online: 15 March 2021 (15:31:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0087.v1

Nutritional Quality during Development Alters Insulin-Like Peptides Expression and Physiology of the Adult Yellow Fever Mosquito, Aedes aegypti

Rana Pooriirouby, Arvind Sharma, Joshua Beard, Jeremiah Reyes, Andrew Nuss, Monika Gulia-Nuss

Subject: Biology And Life Sciences, Insect Science Keywords: insulin-signaling; insulin receptor; Aedes aegypti; mosquitoes; insulin; insulin-like peptides; nutrition; hyperinsulinemia; larval-diet; metabolic reserves

Online: 6 June 2018 (11:55:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0101.v1

Nutrient Resources Recovery by a Creative Co-Composting Method of Municipal Solid Wastes and Wastewater Treatment Plant Sludge

Saeed Nemati, Bijan Samali, Farzaneh Tahmoorian, Nader Mokhtarani, Farshad Sanati

Subject: Engineering, Civil Engineering Keywords: nutrient resources recovery , chemical oxygen demand (COD), carbon to nitrogen ratio (C/N), co-composting, wastewater sludge, municipal solid wastes (MSW)

Online: 8 March 2019 (04:06:02 CET)

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