Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function

Version 1 : Received: 22 July 2021 / Approved: 26 July 2021 / Online: 26 July 2021 (09:07:38 CEST)

How to cite: Hassan, S.S.; Lundstrom, K.; Serrano-Aroca, Á.; Adadi, P.; Aljabali, A.; Redwan, E.; Lal, A.; Kandimalla, R.; El-Aziz, T.; Choudhury, P.; Azad, G.; Sherchan, S.; Tambuwala, M.; Chauhan, G.; Takayama, K.; Barh, D.; Palù, G.; Basu, P.; Uversky, V.N. Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function. Preprints 2021, 2021070554 (doi: 10.20944/preprints202107.0554.v1). Hassan, S.S.; Lundstrom, K.; Serrano-Aroca, Á.; Adadi, P.; Aljabali, A.; Redwan, E.; Lal, A.; Kandimalla, R.; El-Aziz, T.; Choudhury, P.; Azad, G.; Sherchan, S.; Tambuwala, M.; Chauhan, G.; Takayama, K.; Barh, D.; Palù, G.; Basu, P.; Uversky, V.N. Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function. Preprints 2021, 2021070554 (doi: 10.20944/preprints202107.0554.v1).

Abstract

The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made fighting of the COVID-19 pandemic is a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in the lung tissues. Mutations and co-mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, We highlight 128 single mutations and 35 co-mutations in the unique SARS-CoV-2 ORF10 variants in this article. The possible predicted effects of these mutations and co-mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.

Keywords

SARS-CoV-2; ORF10; Co-mutations; Intrinsic Protein Disorder; Ubiquitin Ligase Complex

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