Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function

Sk. Sarif Hassan
* ,
Kenneth Lundstrom
,
Ángel Serrano-Aroca
ORCID logo ,
Parise Adadi
,
Alaa Aljabali
ORCID logo ,
Elrashdy Redwan
,
Amos Lal
,
Ramesh Kandimalla
,
Tarek El-Aziz
ORCID logo ,
Pabitra Choudhury
,
Gajendra Azad
ORCID logo ,
Samendra Sherchan
,
Murtaza Tambuwala
ORCID logo ,
Gaurav Chauhan
ORCID logo ,
Kazuo Takayama
ORCID logo ,
Debmalya Barh
ORCID logo ,
Giorgio Palù
,
Pallab Basu
,
Vladimir N Uversky
* ORCID logo
Version 1 : Received: 22 July 2021 / Approved: 26 July 2021 / Online: 26 July 2021 (09:07:38 CEST)

A peer-reviewed article of this Preprint also exists.

Hassan, Sk.S.; Lundstrom, K.; Serrano-Aroca, Á.; Adadi, P.; Aljabali, A.A.A.; Redwan, E.M.; Lal, A.; Kandimalla, R.; El-Aziz, T.M.A.; Pal Choudhury, P.; et al. Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function. International Journal of Biological Macromolecules 2022, 194, 128–143, doi:10.1016/j.ijbiomac.2021.11.151. Hassan, Sk.S.; Lundstrom, K.; Serrano-Aroca, Á.; Adadi, P.; Aljabali, A.A.A.; Redwan, E.M.; Lal, A.; Kandimalla, R.; El-Aziz, T.M.A.; Pal Choudhury, P.; et al. Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function. International Journal of Biological Macromolecules 2022, 194, 128–143, doi:10.1016/j.ijbiomac.2021.11.151.

Abstract

The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made fighting of the COVID-19 pandemic is a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in the lung tissues. Mutations and co-mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, We highlight 128 single mutations and 35 co-mutations in the unique SARS-CoV-2 ORF10 variants in this article. The possible predicted effects of these mutations and co-mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.

Keywords

SARS-CoV-2; ORF10; Co-mutations; Intrinsic Protein Disorder; Ubiquitin Ligase Complex

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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