Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 and Crosstalk between the Hallmarks of Aging

Version 1 : Received: 11 April 2020 / Approved: 12 April 2020 / Online: 12 April 2020 (04:52:44 CEST)
Version 2 : Received: 15 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (18:25:28 CEST)

A peer-reviewed article of this Preprint also exists.


Within the past several decades, the emergence of new viral diseases with more severe health complications and mortality, primarily in older adults with comorbidities, is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitant reduced immunity. The emergence of new infectious coronaviruses such as SARS-CoV-2 has resulted in the coronavirus disease 2019 (COVID-19). The result is increased morbidity and mortality in persons with underlying chronic diseases and among those with compromised defense mechanisms, regardless of age and among older adults who are more likely to fit these categories. COVID-19 appears to be primarily an upper respiratory disease. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia, acute respiratory distress syndrome (ARDS), lung fibrosis, cardiac t complication, acute kidney injury, hospitalization, and high mortality have been reported in older adults with COVID-19, that result from pathogen-host interactions. Here, we review potential interactions of the coronavirus and host cellular responses in relation to hallmarks of aging including genomic instability, telomere attrition, impaired autophagy, mitochondrial dysfunction, innate immunosenescence, inflammation and inflammasomes, adaptive immunosenescence, and epigenetic alterations, that likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults.


COVID-19; pandemic; co-morbidity; aging; hallmarks of aging; anti-aging


Medicine and Pharmacology, Pathology and Pathobiology

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