Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Immunophenotyping of Circulating Leukocytes Reveal Non-specific Activation of Innate and Adaptive Immune Systems in Multi-System Inflammatory Syndrome of Childhood Temporally Associated with SARS-Cov-2 Infection: Descriptive Cohort Study

Version 1 : Received: 10 July 2020 / Approved: 12 July 2020 / Online: 12 July 2020 (12:09:35 CEST)

How to cite: J. Carter, M.; Fish, M.; Jennings, A.; Doores, K.J.; Wellman, P.; Seow, J.; Acors, S.; Timms, E.; Kenny, J.; Neil, S.; H. Malim, M.; Tibby, S.M.; Shankar-Hari, M. Immunophenotyping of Circulating Leukocytes Reveal Non-specific Activation of Innate and Adaptive Immune Systems in Multi-System Inflammatory Syndrome of Childhood Temporally Associated with SARS-Cov-2 Infection: Descriptive Cohort Study. Preprints 2020, 2020070252 (doi: 10.20944/preprints202007.0252.v1). J. Carter, M.; Fish, M.; Jennings, A.; Doores, K.J.; Wellman, P.; Seow, J.; Acors, S.; Timms, E.; Kenny, J.; Neil, S.; H. Malim, M.; Tibby, S.M.; Shankar-Hari, M. Immunophenotyping of Circulating Leukocytes Reveal Non-specific Activation of Innate and Adaptive Immune Systems in Multi-System Inflammatory Syndrome of Childhood Temporally Associated with SARS-Cov-2 Infection: Descriptive Cohort Study. Preprints 2020, 2020070252 (doi: 10.20944/preprints202007.0252.v1).

Abstract

We describe the innate and adaptive immune system trajectory in Multi-system inflammatory syndrome of childhood (MIS-C), at acute(within 72 hours of hospitalization), resolution (at clinical improvement) and convalescent phase. In our cohort, in the acute phase, 68% of the children were SARS-CoV-2 seropositive, with hypercytokinenemia (high interleukin(IL)-1beta,IL-6,IL-8,IL-10,IL-17, interferon gamma), procoagulant state, myocardial dysfunction, activated neutrophils and monocytes; differential T and B cell subset lymphopenia; activated chemokine receptor type-7 positive and gamma-delta T cell subsets; antigen presenting cells had reduced HLA-DR expression; and B-cell class-switch responses occurred with illness resolution. MIS-C is an immunopathogenic illness associated with SARS-CoV-2 infections in children.

Subject Areas

SARS-Co-V2; Paediatric hyperinflammation; MIS-C; PIMS-TS

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