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Preprint REVIEW | doi:10.20944/preprints201701.0039.v1

Curcumin a Multifaceted Compound with Hormetic Behaviour that Mediates an Intricate Crosstalk between Mitochondrial Biogenesis, Mitophagy, Mitophagic Death and Apoptosis

Nathan Earl Rainey, Aoula Moustapha, Raphaelle Parker, Patrice Xavier Petit

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: apoptosis; autophagy; cancer; crosstalk; curcumin; endoplasmic reticulum; hormatic behavior; lysosomes; mitochondria

Online: 10 January 2017 (03:46:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0122.v2

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Alex Shneider, Aleksandr Kudriavtsev, Anna Vakhrusheva

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: melatonin; coronavirus; pandemic; SARS-CoV-2; bat; lung; apoptosis; programmed cell death; mortality; morbidity; COVID-19; drug

Online: 9 April 2020 (09:24:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0145.v1

Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells

Liang Cai, Li-Fang Wang, Jun-Ping Pan, Xiang-Nan Mi, Zheng Zhang, Hai-Ju Geng, Jia-Hui Wang, Song-Hui Hu, Wei Zhang, Qin Gao, Wu-Tian Wu, Huan-Min Luo

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: methyl 3,4-dihydroxybenzoate; oxidative stress; apoptosis; neuroprotection; nuclear factor erythroid 2-related factor 2

Online: 15 August 2016 (10:42:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0060.v1

Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

Thomas Ziebart, Sebastian Blatt, Junho Jung, Andreas Pabst, Christian Walter, Frank Halling, Paul Heymann, Andreas Neff, Leonardo Righesso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingiva; bisphosphonate; soft tissue; fibroblasts; keratinocytes; bisphosphonate associated osteonecrosis of the jaws

Online: 15 October 2016 (08:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0003.v6

Farey Sequences and the Riemann Hypothesis

Darrell Cox

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann hypothesis, Farey sequence, Gauss sum associated with a Dirichlet character

Online: 10 August 2016 (11:35:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0001.v1

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

Shan-Ling Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Chih-Hsiang Hsu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: protein-disulfide isomerase-associated 3; osteoarthritis; extracorporeal shockwave therapy; 1α,25-Dihydroxyvitamin D3 signaling pathway; two dimensional electrophoresis

Online: 1 September 2016 (10:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0188.v1

The Apoptosis Induction of Oleandrin on Osteosarcoma Cells through Regulating Mitochondrial- and Death Receptor-Dependent Apoptotic Pathways in Vitro

Yunlong Ma, Bin Zhu, Lei Yong, Chunyu Song, Xiao Liu, Huilei Yu, Peng Wang, Zhongjun Liu, Xiaoguang Liu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oleandrin; osteosarcoma; apoptosis; caspases

Online: 22 August 2016 (05:35:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201608.0043.v1

Arms Race between Enveloped Viruses and the Host ERAD Machinery

Dylan A. Frabutt, Yong-Hui Zheng

Subject: Biology And Life Sciences, Virology Keywords: enveloped viruses; viral glycoproteins; endoplasmic reticulum-associated degradation; ERAD; unfolded protein response; UPR; ER stress

Online: 4 August 2016 (11:44:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0098.v1

Induction of G2M Arrest by Flavokawain A, A Kava Chalcone, Increases the Responsiveness of HER2 Overexpressing Breast Cancer Cells to Herceptin

Danielle D. Jandial, Lauren S. Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H. Hoang, Xiaolin Zi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Flavokawain A; HER2 overexpression; resistance to apoptosis

Online: 23 January 2017 (03:30:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0155.v1

Cancer-associated Fibroblasts: Origins, Heterogeneity and Functions in Tumor Microenvironment

Kevin Dzobo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Tumor microenvironment; tumor stroma; cancer-associated fibroblasts; heterogeneity; biomarkers; cancer; The Cancer Genome Atlas; gene expression; computational biology

Online: 15 January 2020 (12:56:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0218.v1

Oleanolic Acid Induces p53 Dependent Apoptosis via the ERK/JNK/AKT Pathway in Cancer Cell Lines

Gyeong-Ji Kim, Hyeon-Ju Jo, Kang-Hyun Chung, Kwon-Jai Lee, Jeung Hee An

Subject: Chemistry And Materials Science, Food Chemistry Keywords: anticancer activity; apoptosis; oleanolic acid; cell cycle arrest; mapk signaling

Online: 31 May 2017 (11:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0107.v1

Evidence for the Involvement of Toll-Like Receptor 4 (TLR4)-Mediated Apoptosis in Gynecological Cancers

Jinyoung Won, Youngjeon Lee, Kyu-Tae Chang, Yonggeun Hong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: apoptosis; gynecologic cancer; lipopolysaccharide; proliferation; Toll-like receptor

Online: 20 December 2016 (11:12:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0016.v1

Nrf2 Inhibits Periodontal Ligament Stem Cell Apoptosis under Excessive Oxidative Stress

Yanli Liu, Hongxu Yang, Yinhua Zhao, Min Zhang, Yongjin Chen

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: periodontitis; the periodontal ligament stem cells; the nuclear factor-erythroid 2-related factor 2; oxidative stress; apoptosis

Online: 4 April 2017 (08:58:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201702.0098.v1

MicroRNAs in the Communication between Cancer Associated Fibroblasts (CAF) and Cancer Cells

Maren Schoepp, Anda Jana Stroese, Joerg Haier

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA; cancer associated fibroblasts; cell-cell communication; transformation; epigenetic

Online: 28 February 2017 (10:29:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0020.v1

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N. Chamcheu, Abu Bakar Siddique, Melissa B. Bloch, Sergette Banang Mbeumi, Abiola S. Babatunde, Mohammad B. Uddin, Felicite K. Noubissi, Peter W. Jurutka, Yong-Yu Liu, Vladimir S. Spiegelman, G. Kerr Whitfield, Khalid A. El Sayed

Subject: Medicine And Pharmacology, Dermatology Keywords: Annona muricata; apoptosis; basal cell carcinoma; cutaneous squamous cell carcinoma; graviola; Hedgehog signaling pathway; natural products chemistry; non-melanoma skin cancer

Online: 1 June 2018 (13:00:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0234.v1

Sequence Properties of the MAAP Protein and of the VP1 Capsid Protein of Adeno-Associated Viruses

David G. Karlin

Subject: Biology And Life Sciences, Virology Keywords: adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix

Online: 17 February 2020 (02:42:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0147.v1

Novel Therapeutic Targets and Biomarkers for the Treatment of Progressive Supranuclear Palsy

Imogen Tyer, Alison Hill

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: PSP; Progressive Supranuclear Palsy; 4R-tau; four-repeat tau; MAPT; Microtubule-associated ligand; PET; Positron Emission Tomography

Online: 12 June 2020 (09:41:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0066.v2

Enhanced Autophagy in Polycystic Kidneys of AQP11 Null Mice

Yasuko Tanaka, Mayumi Watari, Tatusya Saito, Yoshiyuki Morishita, Kenichi Ishibashi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: proximal tubule; LC3; ER stress; apoptosis; PKD

Online: 14 November 2016 (04:05:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0126.v1

2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway

Jeong-Hyeon Ko, Jae Hwi Lee, Sang Hoon Jung, Seok-Geun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: 2,5-Dihydroxyacetophenone; multiple myeloma; MAPK; apoptosis

Online: 29 June 2017 (08:40:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints201705.0209.v2

Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis

Jung Min Shim, Jinhee Kim, Tanel Tenson, Ji-Young Min, Denis E. Kainov

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: influenza virus; apoptosis; antiviral agent; innate immunity; host response

Online: 14 August 2017 (04:41:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0413.v1

A Current Overview of the Molecular Effects of Nanosilver

Shana J. Cameron, William G. Willmore

Subject: Biology And Life Sciences, Biophysics Keywords: silver nanoparticles; nanosilver; endocytosis; oxidative stress; reactive oxygen species; inflammation; wound healing; hypoxia; mitochondria; endoplasmic reticulum stress; unfolded protein response; autophagy; apoptosis; angiogenesis; epigenetics; genotoxicity; cancer; anti-cancer

Online: 28 May 2018 (15:51:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0059.v1

Sequestration Effect on the Open-Cyclic Switchable Property of Warfarin by Cyclodextrin: Ultrafast Dynamical Study

Naji Al-Dubaili, Na'il Saleh

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: open-cyclic tautomers; molecular switching; decay-associated spectra; warfarin; excited-state lifetime; cyclodextrins

Online: 21 July 2017 (04:56:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0093.v1

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Vibeke Andersen, Axel Kornerup Hansen, Berit Lilienthal Heitmann

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: lifestyle factors; chronic inflammatory diseases; treatment result; treatment response; diet; meat intake; dietary pattern; food; mucosa associated bacteria; epithelium-associated bacteria; microbiome; fibre intake; personalized medicine; mucus; sulphate-reducing bacteria; mucin-degrading bacteria; Western style diet; anti-TNF

Online: 15 March 2017 (07:29:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0082.v2

Resveratrol Sensitizes Lung Cancer Cell to TRAIL by p53 Independent and Suppression of Akt/NF-κB Signaling

Mohammad Rasheduzzaman, Jae-Kyo Jeong, Sang-Youel Park

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Resveratrol; TRAIL; apoptosis; lung cancer cells; NF-κB; Cytochrome c

Online: 13 August 2018 (06:18:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0157.v1

Docosahexaenoic Acid Induces Cell Death through Downregulation of Hedgehog Signaling via Surt6 Activation in Human EGFR Mutant Non-Small Cell Lung Cancer

Soyeon Jeong, Kaipeng Jing, Soyeon Shin, Soyeon Kim, Seung-Hyeon Han, Yoon-Seon Yoo, Young-Joo Jeon, Jun-Young Heo, Gi-Ryang Kweon, Seung-Kiel Park, Jong-Il Park, Kyu Lim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: docosahexaenoic acid; apoptosis; SIRT6; Hedgehog signaling; non-small cell lung cancer cells

Online: 24 October 2017 (05:43:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0007.v1

The Application of Non-Invasive Apoptosis Detection Sensor (IADS) on Histone Deacetylation Inhibitors (HDACi) Induced Breast Cancer Cell Death

Kai-Wen Hsu, Chien-Yu Huang, Ka-Wai Tam, Chun-Yu Lin, Li-Chi Huang, Ching-Ling Lin, Wen-Shyang Hsieh, Wei-Ming Chi, Yu-Jia Chang, Po-Li Wei, Chia-Hwa Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: non-invasive apoptosis detection sensor; breast cancer; HDACi

Online: 1 December 2017 (12:08:13 CET)

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Preprint REVIEW | doi:10.20944/preprints201709.0027.v1

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Valeria La Marca, Alessandra Fierabracci

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: EVs; endothelial-derived microparticles; platelet-derived microparticles; non-invasive biomarkers; miRNAs signature; diabetes associated complications; micro-macrovascular damage; diabetic nephropathy

Online: 8 September 2017 (09:38:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0068.v1

Human MAP tau based targeted cytolytic fusion proteins

Olusiji Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human cytolytic fusion proteins; immunotherapy; microtubule associated protein tau (MAP); cancer; inflammatory diseases

Online: 15 June 2017 (12:02:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0314.v1

Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Yoshio Sumida, Masashi Yoneda, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Hideki Hayashi, Takashi Kobayashi, Kento Imajo, Masato Yoneda, Toshifumi Tada, Takumi Kawaguchi, Yuichiro Eguchi, Oeda Satoshi, Hirokazu Takahashi, Eiichi Tomita, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group of NAFLD (JSG-NAFLD)

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: hepatic fibrosis; Mac-2 binding protein glycated isomer; apoptosis inhibitor of macrophage; patatin-like phospholipase domain-containing protein 3; α-fetoprotein; PIVKA-II

Online: 14 July 2020 (13:55:16 CEST)

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Working Paper REVIEW

Role of Nucleoid Associated Protein HU in the Intercellular and Extracellular Milieu

Debayan Dey

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: nucleoid-associated proteins (NAPs); moonlighting proteins; drug target; biofilm; specificity determination; phylogenetic analysis

Online: 7 June 2020 (09:07:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0163.v1

Shaping Light in Backward-Wave Nonlinear Hyperbolic Metamaterials

Alexander K. Popov, Sergey A. Myslivets, Vitaly V. Slabko, Victor A. Tkachenko, Thomas F. George

Subject: Physical Sciences, Optics And Photonics Keywords: optical metamaterials; fundamental concepts in photonics; light-matter interactions at the subwavelength and nanoscale; fundamental understanding of linear and nonlinear optical processes in novel metamaterials underpinning photonic devices and components; advancing the frontier of nanophotonics with the associated nanoscience and nanotechnology; nanostructures that can serve as building blocks for nano-optical systems; use of nanotechnology in photonics; nonlinear nanophotonics, plasmonics and excitonics; subwavelength components and negative index materials; slowing, store, and processing light pulses; materials with such capabilities that could be used for optical sensing, tunable optical delay lines, optical buffers, high extinction optical switches, novel image processing hardware, and highly-efficient wavelength converters

Online: 26 February 2018 (11:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0271.v1

Blackcurrant Leaf Chlorosis Associated Virus: Next-Generation Sequencing Reveals an Extraordinary Virus with Multiple Genomic Components Including Evidence of Circular RNA

Delano James, James Phelan, Daniel Sanderson

Subject: Biology And Life Sciences, Plant Sciences Keywords: Idaeovirus; Blackcurrant leaf chlorosis associated virus; next-generation sequencing (NGS); bridge reads; abutting primers; RNase R digestion; circular RNA; concatenated RNA

Online: 30 March 2018 (11:40:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0520.v1

Bafilomycin A1 Induces Caspase-Dependent Apoptosis and Inhibits Autophagy Flux in Diffuse Large B Cell Lymphoma

Fang Li, Ying Hu, Yizhou Hu, Ren Zhou, Zhengrong Mao

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: apoptosis; autophagy; bafilomycin A1; diffuse large B cell lymphoma

Online: 22 July 2021 (13:43:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0038.v1

STAT3 and STAT5 Activation in Solid Cancers

Sebastian Igelmann, Heidi A. Neubauer, Gerardo Ferbeyre

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: solid cancers; cell cycle; apoptosis; inflammation; mitochondria; stemness; tumor suppression

Online: 5 August 2019 (03:43:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0212.v1

Selective Cytotoxic Effects of Annona Squamosa Leaves against Breast Cancer Cells via Apoptotic Signaling Proteins

Rawan Al-Nemari, Abir Ben Bacha, Abdulrahman Al-Senaidy, Maha Arafah, Hadel Al-Saran, Nael Abutaha, Abdelhabib Semlali

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Annona squamosa; phytomedicine; proliferation; apoptosis; migration; estrogen receptor; tumor size

Online: 12 May 2020 (12:37:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0331.v1

Coronavirus 2019 Infection in People with Associated Co-Morbidities: Case Fatality and ACE2 Inhibitors Treatment Concerns

Maryam Honardoost, Rokhsareh Aghili, Mohammad E. Khamseh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes

Online: 19 April 2020 (05:42:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0196.v1

Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury

Saurav Bhowmick, Veera D'Mello, Nizmi Ponery, P.M. Abdul-Muneer

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: traumatic brain injury; fluid percussion injury; neurodegeneration; apoptosis; sensorimotor deficit

Online: 28 December 2017 (08:58:32 CET)

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Preprint REVIEW | doi:10.20944/preprints201804.0063.v1

Probing Molecular Insights of Zika Virus-Host Interactions

Ina Lee, Sandra Bos, Ge Li, Shusheng Wang, Gilles Gadea, Philippe Despres, Richard Y. Zhao

Subject: Biology And Life Sciences, Virology Keywords: Zika virus; ZIKV-host interactions; viral pathogenesis; cell surface receptors; antiviral responses; viral counteraction; cytopathic effects; microcephaly; ZIKV-associated neurologic disorders

Online: 5 April 2018 (05:34:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0346.v1

Characterization of Mitochondrial GSH Transporters and Their Role in RPE Protection

Mo Wang, Ling-ing Lau, Parameswaran G. Sreekumar, Christine Spee, Lin Liu, David R. Hinton, Srinivas R. Sadda, Ram Kannan

Subject: Medicine And Pharmacology, Ophthalmology Keywords: retinal pigment epithelium (RPE); oxidative stress; mitochondria; apoptosis; 2-oxoglutarate carrier (OGC); dicarboxylate carrier (DIC); glutathione (GSH); mitochondrial GSH (mGSH)

Online: 19 July 2018 (06:15:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0034.v1

Crosstalk between Autophagy and Apoptosis Modulates T-2 Toxin-Induced Toxicity in Liver Cells

Jing Wu, Yu Zhou, Zhihang Yuan, Jine Yi, Jingshu Chen, Naidong Wang, yannan tian

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: T-2 toxin, toxicity, autophagy, apoptosis

Online: 2 October 2018 (16:51:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0342.v1

Apoptosis and Necrosis on T47D Cells Induced by Shiga-Like Toxin from Local Isolates of Escherichia coli O157:H7

I Wayan Suardana, Komang Januartha Putra Pinatih, Dyah Ayu Widiasih

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: apoptosis; breast cancer; E. coli O157:H7; necrosis; Shiga-like toxin

Online: 26 April 2018 (10:41:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0244.v1

B Cells Over-Activation by Viral Proteins <70 kDa Causes Th2 Immune Suppression in COVID-19 Sepsis

Javier Martín

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: COVID-19; SARS-CoV-2; antigen; monovalent; oligovalent; protein; kilodalton (kDa); Th1 response; Th2 response; B cell activation; B cell receptor (BCR); macrophage; dendritic cell; apoptosis; subcapsular sinus; immunoglobulin; interleukin; cytokine; Cytokine Storm Syndrome (CSS); allergen; immune paralysis; vaccine; polymer

Online: 14 May 2020 (15:19:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0029.v2

Incidence and Determinants of Health Care Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study

Mamta Dhaneria, Sachin Jain, Poonam Singh, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: blood stream health care associated infections; neonates; risk factors, antibiotic use, antibiotic resistance; neonatal intensive care unit; India

Online: 30 January 2018 (08:03:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0337.v1

Effects of Periostracum Cicadae on Cytokines and Apoptosis Regulatory Proteins in IgA Nephropathy Rat Model

Lu Yang, Yan Wang, Aobulikasimu Nuerbiye , Ping Cheng, Jin-Hui Wang, Rena Kasimu, Hong Li

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Periostracum cicadae; IgA nephropathy; inflammation; fibrosis; apoptosis

Online: 24 May 2018 (06:32:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0634.v1

Compound 3K, a Specific Pyruvate Kinase M2 Inhibitor, Induces Autophagic Cell Death through the Disruption of the Glycolytic Pathway in Ovarian Cancer Cells

Jae Hyeon Park, Amit Kundu, Hae Ri Kim, Su Hyun Lee, Chunxue Jiang, Ye Seul Kim, So Young Kyung, So Hyun Park, Hyung Sik Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: compound 3K; ovarian cancer; pyruvate kinase M2; autophagy; apoptosis

Online: 26 September 2020 (13:34:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0098.v1

Expression and Characterization of a Novel Recombinant Cytotoxin II from Naja naja oxiana Venom: A Potential Treatment for Breast Cancer

Afshin Derakhshani, Nicola Silvestris, Khalil Haji‐Asgarzadeh, Sara Mahmoudzadeh, Mohammad Fereidouni, Angelo Virgilio Paradiso, Oronzo Brunetti, Deyhim Atarod, Hossein Safarpour, Behzad Baradaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; snake venom; cytotoxin II; recombinant protein; apoptosis; cell cycle progression; cytotoxicity

Online: 6 May 2020 (15:12:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0279.v1

Anticancer Activity of Selective and Non-Selective Beta Adrenoreceptor Blockers against Non-Small Cell Lung Cancer Cell Lines

Marina Sidorova, Vilma Petrikaite

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: beta adrenoblocker; anticancer; non-small cell lung cancer; clonogenic; apoptosis; necrosis

Online: 25 July 2019 (06:20:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0085.v1

Synthesis, Biological Evaluation and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization

Malose J. Mphahlele, Nishal Parbhoo

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: 7-acetamido-2-aryl-5-bromoindoles; trifluoroacetylation; cytotoxicity; apoptosis; tubulin polymerization; molecular docking

Online: 4 May 2018 (07:47:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0242.v1

Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis Via Inhibition of XIAP/NF-kB and Activation of Caspases and Death Receptor 4

Deoksoo Ahn, HyoJung Lee, Jisung Hwang, Hyukgyu Han, BumSang Shim, Sunghoon Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Non-small cell lung cancer; Lambertianic acid; Apoptosis; TRAIL; XIAP; NF-B

Online: 18 April 2018 (15:25:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0184.v1

Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in HT29 Colon Cancer Cells

Paola Sena, Stefano Mancini, Marta Benincasa, Francesco Mariani, Carla Palumbo, Luca Roncucci

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: colorectal cancer cells; metformin; apoptosis; oxidative stress

Online: 21 March 2018 (03:30:49 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0036.v1

Molecular Aspects of Varicella-Zoster Virus Latency

Daniel P. Depledge, Tomohiko Sadaoka, Werner J. D. Ouwendijk

Subject: Biology And Life Sciences, Virology Keywords: varicella-zoster virus; latency; reactivation; sensory ganglia; VZV latency-associated transcript; open reading frame 63; RNA-sequencing; epigenetics; immunity

Online: 4 June 2018 (11:49:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0521.v1

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.

Atsushi Saito, Kazunori Imaizumi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; ER morphology; Mitochondria-associated ER membrane; ER-PM contact sites

Online: 26 September 2018 (15:44:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0239.v1

Saringosterol Acetate from a Popular Edible Seaweed, Hizikia Fusiformis Attenuated Proliferation of Human Lung Adenocarcinoma Epithelial Cells (A549 Cells) via Apoptosis Signaling Pathway

Ji-Hyeok Lee, Ju-Young Ko, Chuk Young Kim, Yong-Tae Kim, Jaeil Kim, You-Jin Jeon

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: edible marine alga; anticancer; hizikia fusiformis; saringosterol acetate; apoptosis

Online: 20 November 2019 (11:19:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0141.v1

Gambogenic Acid Triggers Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells through Activating Volume-Sensitive Outwardly Rectifying Chloride Channels

Jingjing Su, Ting Xu, Genling Jiang, Mengru Liang, Hui Cheng, Mei Hou, Qinglin Li

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Gambogenic acid; apoptosis; CNE-2Z cells; volume-sensitive outwardly rectifying chloride

Online: 8 June 2018 (16:00:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0003.v1

Induction of Apoptosis and Cell Cycle Arrest in two Human Cancer A549 and HT29 Cells Lines by Barhi Date Palm Kernels Extracts and Three Isolated Cytotoxic Compounds

Israa Mahmud, Mohamed E. S. Mirghani, Mothanna Al-Qubaisi, Beh Yee, Norsharina Ismail, Abdullah Rasedee, Faridah Yusof, Munira Shahabuddin, Ma'an Al-khatib, Nassereldeen Kabbashi, Yumi Hashim, Ayah Hilles, Phirdaous Abbas

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: apoptosis; Barhi date palm kernels (BDPK); extractable polyphenols (EPP); non-extractable polyphenols (NEPP); nobiletin (NOB); tectorigenin (TEC); persicogenin (PERSI).

Online: 3 June 2019 (08:33:05 CEST)

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Background and objectives: The initiation of apoptotic death in cancer cells is the aim of many chemotherapeutic strategies. As many anticancer agents have been discovered in natural plant sources, the search for novel phytochemicals displaying anticancer activities continues at a tremendous rate. This study was conducted to evaluate the effect of extractable polyphenols (EPP); non-extractable polyphenols (NEPP); nobiletin (NOB); tectorigenin (TEC) and persicogenin (PERS) from Barhi date palm kernels (BDPK) extracts on the induction of apoptosis in human lung cancer A549 and colon cancer HT29 cell lines. Materials and Methods: The anticancer activities were determined using MTT and trypan blue exclusion assays. Flow cytometry analysis was performed to study the cell viability, cell cycle arrest and apoptosis. The underlying mechanism of apoptosis induced by crude extracts and the purified compounds was investigated using caspase-3, -8 and -9 assays and the mitochondrial membrane potential assay. Results: The findings indicate that both BDPK extracts and the purified compounds do exert induced cell death on A549 and HT29 cells. The results observed from MTT- assay and trypan blue exclusion indicate that the cytotoxic effects of both plant extracts and the three isolated flavonoids are dose-dependent with higher cell death after 72 hours treatment. Treatment of human lung and colon cancer cells with EPP, NEPP, NOB, TEC and PERSI induced late stages of apoptosis as there was evidence of the DNA degradation and high percentage of the cells population was situated at sub-G1 phase, indicating a high population of apoptotic cells. Conclusions: Study of the apoptotic mechanism demonstrated that EPP and NEPP exhibited dependent mitochondrial signalling pathway as seen with caspase-9 and induced receptor-mediated (extrinsic) apoptotic pathway as seen with caspase-8. Therefore, our results suggest that BDPK extracts and the three isolated flavonoids could be a good candidate for developing anticancer agents.

Preprint ARTICLE | doi:10.20944/preprints201807.0066.v1

Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells

Hyejin Park, Ye Ji Jeong, Na-Kyung Han, Joong Sun Kim, Hae-June Lee

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: oridonin; radiation; sensitization; ROS; apoptosis

Online: 4 July 2018 (10:19:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0357.v1

Transcriptomics Reveals Granulosa Cell’s Coping through Redox, Inflammatory, Metabolic and Cytoskeleton Mechanisms under Acute Heat Stress

Abdul Sammad, Hanpeng Luo, Lirong Hu, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; apoptosis; oxidative stress; RNA-seq; transcriptomics; differentially expressed genes; signaling pathways

Online: 28 February 2022 (11:08:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0776.v1

Saponins in Cancer Treatment: Current Progress and Future Prospects

Olushola Olalekan Elekofehinti, Opeyemi Iwaloye, Femi Olawale, Esther Opeyemi Ariyo

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Saponins; anticancer activities; traditional plants; mechanism of action; cell cycle arrest; apoptosis; chemopreventive; future cancer research

Online: 29 April 2021 (14:08:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints201903.0116.v1

Red Beetroot and Betalains as Cancer Chemopreventative Agents

John F. Lechner, Gary D. Stoner

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: beetroot; betanins; cancer chemoprevention; anti-oxidant; inflammation; apoptosis

Online: 11 March 2019 (08:00:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0395.v1

Radix Scrophulariae Aqueous Extract Seems to Exert Neuroprotective Effects on Cerebral Ischemia and Reperfusion Injury with Inhibiting Apoptosis via ERK1/2 and p-38 MAPK Pathway

Weijie Xie, Ping Zhou, Xuelian Zhang, Chenyang Zhang, Xiangbao Meng, Guibo Sun, Xiaobo Sun

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Radix scrophulariae; ischemia stroke; cerebral ischemia and reperfusion; apoptosis; ERK1/2 MAPK; p-38 MAPK

Online: 22 August 2018 (11:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0179.v1

Δ9–Tetrahydrocannabinol (THC)-Rich Compositions from Cannabis Have Cytotoxic Activity Against Ovarian Cancer Cells and Act Synergistically With Niraparib in vitro

Nurit Shalev, Michelle Kendall, Seegehalli M Anil, Ajjampura C Vinayaka, Hinanit Koltai

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: ovarian cancer; cannabis; phytocannabinoids; apoptosis; cytotoxicity; cell cycle; MAPK4; PARP1

Online: 9 September 2021 (11:57:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0667.v1

Sequenced Combinations of Cisplatin and Selected Phytochemicals Towards Overcoming Drug Resistance in Ovarian Tumour Models

Safiah Ibrahim Althurwi, Jun Q. Yu, Philip Beale, Fazlul Huq

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Ovarian cancer; drug resistance; apoptosis; proteomics; combination; cytotoxicity; artemisinin; oleanolic acid; platinum drugs; cisplatin

Online: 30 August 2020 (12:06:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0432.v1

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK 3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

Sung Min Hwang, Hyo-Jung Lee, Ji Hoon Jung, Deok Yong Sim, Jisung Hwang, Ji Eon Park, Sunghoon Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast cancer; Moracin D; Apoptosis; FOXM1; β-catenin; GSK 3β

Online: 24 August 2018 (10:58:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0246.v2

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Alessia Mongelli, Carlo Gaetano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: epigenetics, rehabilitation, DNA methylation, histone modification, HDAC, exercise, health span, heart failure, neurodegeneration, cancer, lung fibrosis, bone formation.

Online: 27 August 2018 (15:58:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0186.v1

Roles of Extracellular Vesicles (EVs) Carrying HSPs in Cancer Biomarkers, Immune Surveillance, and Immune Evasion

Eman Taha, Kisho Ono, Takanori Eguchi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy

Online: 17 August 2019 (16:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0347.v1

Cell Cycle Arrest in Different Cancer Cell Lines “Liver, Breast, and Colon” Induce Apoptosis under the Influence of the Chemical Content of Aeluropus lagopoides Leaves Extracts

Kamel Ahmed Saleh, Tahani Hassan Asiri, Serageldin Ibrahim Elbehairi, Mohammed Ali Alshehry, Mohammad Yahya Elfaifi, Adel Mahmoud Al-Ghazzwi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Aeluropus lagopoides; HepG2; HCT-116; MCF-7; apoptosis; chemical composition

Online: 18 September 2018 (11:40:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0161.v1

The role of miR-29a in the regulation, function, and signaling of liver fibrosis

Ying-Hsien Huang, Ya-Ling Yang, Feng-Sheng Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: miR-29a; cholestasis; apoptosis; ER stress; toll like receptors; epigenetics

Online: 11 June 2018 (14:03:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0592.v1

Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum

Laura Lossi, Claudia Castagna, Adalberto Merighi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: caspase-3; cell death; apoptosis; cell proliferation; neurons; glia; cerebellum; development

Online: 26 November 2018 (11:48:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0327.v1

Imaging Cancer-Associated Fibroblasts (CAFs) with FAPi PET

Laura Gilardi, Lighea Simona Airò Farulla, Emre Demirci, Ilaria Clerici, Emanuela Omodeo Salé, Francesco Ceci

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer-associated-fibroblast; fibroblast activation protein; FAPi; Positron emission tomography; FAPi PET; theranostics

Online: 21 January 2022 (13:31:31 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0281.v1

The Role of Apoptotic Signaling in Axon Guidance

Riley Kellermeyer, Leah M. Heydman, Grant S. Mastick, Thomas Kidd

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: axon guidance; growth cone; cytoskeleton; caspases; apoptosis; signal integration; basal level of caspase activity; death associated inhibitor of apoptosis; axon branching; Netrin; DCC; frazzled; slit; robo; Drosophila

Online: 16 September 2018 (09:43:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0043.v1

Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway

Sang-A Kim, Ok-Hwa Kang, Dong-Yeul Kwon

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cryptotanshinone; NSCLC; cell cycle arrest; apoptosis; PI3K/Akt/GSK3β

Online: 2 August 2018 (09:05:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0091.v1

Molecular Docking Studies of a Cyclic Octapeptide-Cyclosaplin from Sandalwood

Abheepsa Mishra, Satyahari Dey

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: apoptosis; cyclosaplin; molecular docking; protein kinases; Sandalwood

Online: 11 June 2019 (09:45:07 CEST)

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Natural products from plants such as, chemopreventive agents attract huge attention because of their low toxicity and high specificity. The rational drug design in combination with structure based modeling and rapid screening methods offer significant potential for identifying and developing lead anticancer molecules. Thus, the molecular docking method plays an important role in screening a large set of molecules based on their free binding energies and proposes structural hypotheses of how the molecules can inhibit the target. Several peptide based therapeutics have been developed to combat several health disorders including cancers, metabolic disorders, heart-related, and infectious diseases. Despite the discovery of hundreds of such therapeutic peptides however, only few peptide-based drugs have made it to the market. Moreover, until date the activities of cyclic peptides towards molecular targets such as protein kinases, proteases, and apoptosis related proteins have never been explored. In this study we explore the in silico kinase and protease inhibitor potentials of cyclosaplin as well as study the interactions of cyclosaplin with other cancer-related proteins. Previously, the structure of cyclosaplin was elucidated by molecular modeling associated with dynamics that was used in the current study. Docking studies showed strong affinity of cyclosaplin towards cancer-related proteins. The binding affinity closer to 10 indicated efficient binding. Cyclosaplin showed strong binding affinities towards protein kinases such as EGFR, VEGFR2, PKB and p38 indicating its potential role in protein kinase inhibition. Moreover, it displayed strong binding affinity to apoptosis related proteins and revealed the possible role of cyclosaplin in apoptotic cell death. The protein-ligand interactions using LigPlot displayed some similar interactions between cyclosaplin and peptide-based ligands especially in case of protein kinases and a few apoptosis related proteins. Thus, the in silico analyses gave an insight of cyclosaplin as a potential apoptosis inducer and protein kinase inhibitor.

Preprint REVIEW | doi:10.20944/preprints202012.0795.v1

Advances in Cellular Immunotherapy: Understanding and Preventing T-cell Dysfunction

Valérie Janelle, Jean-Sébastien Delisle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: T cells; chimeric antigen receptor; transgenic T-cell receptor; tumor-infiltrating lymphocytes; exhaustion; terminal differentiation; senescence; apoptosis; adoptive cell transfer; immunotherapy

Online: 31 December 2020 (12:16:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0479.v1

Suboptimal Health Status of High School Students in Guangzhou, Shanxi, and Tibet, China: A Cross-Sectional Study

Gehendra Mahara, Jiazhi Liang, Zhirong Zhang, Qi Ge, Jinxin Zhang

Subject: Medicine And Pharmacology, Other Keywords: suboptimal health status; associated factors; high school students; Shanxi; Guangzhou; Tibet; China

Online: 20 September 2020 (14:50:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0335.v2

Metabolic and Hormonal Contributors to Neuronal Necrosis in Alzheimer’s Dementia

Michael Overholt

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s Dementia; anaerobic neurotoxicity; inflammation; neuronal apoptosis; Non-REM Sleep

Online: 4 June 2018 (13:16:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0326.v1

Bioactive Compounds from Monotheca Buxifolia Inhibit the Growth of Hepatocellular Carcinoma Cells

Said Hassan, Ashfaq Rehman, Syed Babar Jamal, Yaqin Liu, Shaoyong Lu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: HepG2 cells; cytotoxicity; apoptosis; Hoechst staining; molecular dynamics

Online: 15 September 2020 (04:18:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0374.v1

GRK5 is an Essential Co-repressor for Cardiac Mineralocorticoid Receptor Antagonism induced by Finerenone but not Eplerenone

Victoria L. Desimine, Jennifer Ghandour, Natalie Cora, Celina M. Pollard, Rachel Valiente, Krysten E. Ferraino, Janelle Pereyra, Daniela Pi Noa, Yanelys Duarte, Yaimiry Martinez, Jennifer Maning, Barbara M. Parker, Ava R. Brill, Valentina Guidi, Beatrix Aukszi, Anastasios Lymperopoulos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aldosterone; apoptosis; cardiac myocyte; eplerenone; fibrosis; finerenone; G protein-coupled receptor kinase (GRK)-5; mineralocorticoid receptor; mineralocorticoid receptor antagonist (MRA); signal transduction

Online: 17 September 2020 (05:24:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0386.v1

Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition

Takanori Eguchi, Kisho Ono, Stuart Calderwood, Kuniaki Okamoto

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology

Online: 29 December 2019 (13:46:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0146.v1

A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation

Umasaknar De, Ji Yeon Son, Richa Sachan, Yu Jin Park, Dongwan Kang, Kyungsil Yoon, Byung Mu Lee, In Su Kim, Hyung Ryong Moon, Hyung Sik Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: histone deacetylase inhibitor, MHY2256, p53, apoptosis, autophagy, Ishikawa, endometrial cancer

Online: 7 August 2018 (14:37:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0181.v2

The Role of JMY in p53 Regulation.

Francesco Pezzella, Omanma Adighibe

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: p53, JMY, regulation, apoptosis, motility

Online: 18 April 2018 (13:46:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0542.v1

Neuron Cell Death

Hao Chi, Hui-Yun Chang, Tzu-Kang Sang

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: apoptosis; necroptosis; neurodegeneration

Online: 31 August 2018 (05:56:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0131.v1

The Monoclonal Antibody Recognized Apoptosis-Associated Protein in PCV2-Infected Peripheral Blood Mononuclear Cells

Ling-Chu Hung

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: epitope; monoclonal antibodies; open reading frame 3 protein; apoptosis; p53; porcine circovirus type 2; thimerosal; interfere; antibody binding; lymphocyte

Online: 12 November 2019 (16:20:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0211.v2

HIV-1: Tackling the Obstacles that Limit the Effectiveness of CRISPR-Cas9 Gene Editing of the T Cell Co-receptor CCR5

Tatiana Hillman

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HIV-1; CRISPR-Cas9; T-cells; lipid nanoparticles; gut-associated-lymphoid tissue; Co-receptors; Probiotics; GI Tract,; Gene Editing

Online: 13 April 2020 (10:57:52 CEST)

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HIV-1 is a complicated and perplexing virus. It infects T cells, reverse transcribes its RNA into DNA, utilizes its host DNA machinery to replicate its HIV-DNA, translates the HIV-DNA into proteins, assembles itself for a budding escape from the T cell, and rapidly mutates its conformation. Partially, due to its complexity, there remains no cure for HIV or AIDs. However, recently with the discovery of TALENs, the use of zinc fingers, and most of all the applications of CRISPR-Cas9 technology, has given researchers new hope in finding alternative gene therapies and treatments for diseases. With more focus on CRISPR-Cas9, this new and novel technology uses a guiding RNA, sgRNA, to lead a Cas9 nuclease to its target for deletion or to change that DNA site. CRISPR-Cas9 can delete point mutations and multiple DNA sites. Because CRISPR can alter DNA sequences, several scientists have conducted research into CRISPR, possibly treating more diseases such as cancer, diabetes, and even HIV. HIV-1 drew the focus of a researcher named Dr. Ebina in 2013 when he was the first to design and apply CRISPR-Cas9 to genes found in the binding sites of HIV-1, inhibiting HIV-1 gene expression. Since 2013, several other researchers have blocked HIV replication and infection through CRISPR-Cas9 targeting the receptors of T cells called the CC chemokine receptor 5 or CCR5. HIV-1 binds to the CD4 receptor of T cells, which consists of co-receptors CCR5 and CXCR4. If CCR5 expression can be removed, the HIV virus cannot bind to T-cells, blocking the initial attachment stage, and discontinuing the infection. However, there remain obstacles and issues for the CRISPR deletion of CCR5 for treating HIV-1. The issues include: 1) finding new and safe methods of CRISPR-Cas9 delivery, 2) clearing the latent HIV reservoirs, 3) improving the sgRNA design to avoid off-target mutations or deletions, and 4) effectively analyze the viral escape of HIV from CRISPR-Cas9 modifications. Therefore, the purpose of this review is to discuss possible techniques for removing the obstacles that can lessen the potential of CRISPR to delete CCR5, repressing HIV-1 into long-term remission or a functional cure.

Preprint ARTICLE | doi:10.20944/preprints201911.0206.v1

Curcumin Derivative C212 Inhibits Hsp90 and Eliminates Both Quiescent and Growing Leukemia Cells

Bi Liu, Yunzhu Shen, Huafang Huang, Kimiko Della Croce, Min Wu, Yingjuan Fan, Yang Liu, Jianhua Xu, Guang Yao

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: leukemia; relapse; quiescence; dormancy; curcumin derivative; Hsp90; apoptosis; protein aggregation

Online: 17 November 2019 (14:06:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0315.v1

p53 Reaction to Cellular Stress Maximizes Apoptosis in Glioblastoma

Cheng-Jung Ho, Yu-Hsuan Pao, Hsin-Wen Chen, Wei-Hua Zhu, Ru-Wei Lin, Cheng wei Chu, Joon Khim Loh, Yi-Ren Hong, Chihuei Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glioblastoma; p53; apoptosis; doxorubicin; bortezomib; vorinostat.

Online: 30 January 2019 (13:03:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0342.v1

Reproductive Toxicity of 4-Octylphenol Induced Mitochondria-Mediated Apoptosis in Male Mouse-Specific Niche Cells

Mingtian Zhang, Hyun Jung Park, Kwonho Hong, Chankyu Park, Hyuk Song

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: 4-octylphenol; male sertoli cells; reproductive toxicity; apoptosis; mitochondria

Online: 16 October 2018 (08:35:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints201904.0209.v1

The Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It

Donatella Aldinucci, Cinzia Borghese, Naike Casagrande

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hodgkin lymphoma; tumor microenvironment; immune escape; tumor-associated macrophages

Online: 18 April 2019 (08:14:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0089.v1

Impact of Access to Medicines on Public Health. Problems Associated With Access, Use, and Abuse of Antibiotics

Antonio G. Pisabarro, Denisse P. Rivera de la Torre

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: access to medicines; access to antibuotics; impact of access to medicines on public health; problems associated with access; use; abuse of antibiotics resistance; aware; Africa

Online: 5 May 2020 (17:03:07 CEST)

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Access to medicines is one of the essential problems in Public Health of low- and middle-income countries (LMICs). The World Health Organization (WHO) defines access to medicines as the possibility of "having continuously accessible and affordable medicines in public or private health facilities that are within a kilometer of the place of residence." Access to medicines, as defined by the WHO, is not fully guaranteed in many LMICs and even in many regions of high-resource countries. The WHO identifies several factors as determinants of limitations in the access to medicines: rational selection, affordable prices, sustainable financing, and reliable health services. The action on these factors makes it possible to improve universal access to medicines with consequent improvement in Public Health. Adequate access to antibiotics and vaccination will avoid a large part of the deaths caused by infectious diseases in the LMICs. However, the emergence of resistance and the difficulties in vaccination campaigns due to socio-political or cultural problems make it challenging to fight many easily treatable infectious diseases. The use and abuse of antibiotics are inevitably associated with the appearance of resistances that make them ineffective. Thus, whereas limited access to antibiotics raises mortality rates from infectious diseases, generalized open access to them ends up eliminating their clinical value. Moreover, the contraction of research in this field for many years has reduced the success in discovering new drugs. Additionally, local market regulations, inadequate selection, inaccessible prices, especially for those of second and third-generation, inefficient health systems, and difficulties of administration and control of prescription compliance, especially in the case of combined therapies, are additional obstacles to universal access to antibiotics. In order to simultaneously improve access to antibiotics and keep resistances under control, it is necessary to develop training and education activities at different social levels (from patients to various Health Care Providers) to complement the national or supranational strategic plans.

Preprint REVIEW | doi:10.20944/preprints202005.0158.v1

Dynamics of Bcl-2Protein Phosphorylation: A Mini Review

Abdul Manan, Sidra Ilyas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: apoptosis; cancer; phosphorylation; kinases; Bcl-2

Online: 9 May 2020 (08:40:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0023.v1

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.

Atsushi Saito, Kazunori Imaizumi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; ER morphology; Mitochondria-associated ER membrane; ER-PM contact sites

Online: 2 October 2018 (13:41:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0248.v1

Early Critical Phase Transitions of Pericentromere-Associated Domains in MCF-7 Breast Cancer Cells Committed to Differentiation by Heregulin

Jekabs Krigerts, Kristine Salmina, Talivaldis Freivalds, Felikss Rumnieks, Inna Inashkina, Pawel Zayakin, Michael Hausmann, Jekaterina Erenpreisa

Subject: Biology And Life Sciences, Biophysics Keywords: cancer; differentiation commitment; acridine-orange-DNA test; pericentromere-associated domains (PADs); power law of PAD number vs. size; critical self-organisation; unravelling of PADs; silencing threshold

Online: 15 May 2020 (08:01:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0054.v1

Boophone Haemanthoides (Amaryllidaceae) and Its Bioactive Compounds Attenuate MPP+-Induced Toxicity in an in Vitro Parkinson’s Disease Model

Abobaker S. Ibrakaw, Sylvester I. Omoruyi, Okobi E. Ekpo, Ahmed A. Hussein

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Amaryllidaceae; Boophone haemanthoides; Alkaloids; Terpenoids; Parkinson’s disease; Neuroprotection; Apoptosis

Online: 3 August 2020 (00:08:27 CEST)

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Working Paper REVIEW

Spontaneous Post-translational Modification: Crosstalk of Proteolysis, Autophagy, and Apoptosis in Aging

Victor V. Dyakin, Csaba Vadasz, Thomas M. Wisniewski

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: spontaneous; racemization; apoptosis; post translational modification

Online: 18 November 2020 (11:09:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0006.v1

Castanea sativa Mill. Shells Aqueous Extract Exhibits Anticancer Properties Inducing Cytotoxic and Pro-apoptotic Effects

Nunzio Antonio Cacciola, Giuseppe Squillaci, Mariella D’Apolito, Orsolina Petillo, Francesco Veraldi, Francesco La Cara, Gianfranco Peluso, Sabrina Margarucci, Alessandra Morana

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: chestnut shells; polyphenols; bioactive compounds; apoptosis; cytotoxicity; human cell lines

Online: 1 August 2019 (04:37:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0045.v1

The Novel Thienopyrimidine Derivative, RP-010, Produces Its Efficacy in Prostate Cancer Cells by Inducing the Fragmentation of β-catenin

Haneen Amawi, Noor Hussein, Sai HS Boddu, Chandrabose Karthikeyan, Frederick E. Williams, Charles R. Ashby Jr., Raman Dayanidhi, Piyush Trivedi, Amit Tiwari

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Thienopyrimidines, RP-010, Prostate cancer, Metastasis, Wnt/β-catenin, Apoptosis.

Online: 4 March 2019 (13:37:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0374.v1

Preclinical Evidence of STAT3 Inhibitor, Pacritinib, Overcomes Temozolomide Resistance via Down-Regulating miR-21-enriched Exosomes from M2 Glioblastoma-Associated Macrophages

Hao-Yu Chuang, Yu-kai Su, Heng-Wei Liu, Chao-Hsuan Chen, Shao-Chih Chiu, Der-Yang Cho, Shinn-Zong Lin, Yueh-Sheng Chen, Chien-Min Lin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keywords: Tumor microenvironment (TME), glioblastoma multiforme (GBM), GBM- associated macrophages (GAMs), exosomes, oncomiR-21, STAT3 inhibitor.

Online: 31 May 2019 (08:18:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0346.v1

New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation, Antioxidant Properties and In Vitro Anticancer Effect

Anca Roxana Petrovici, Natalia Simionescu, Andreea Isabela Sandu, Vasile Paraschiv, Mihaela Silion, Mariana Pinteala

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cannabidiol; hemp oil; soft decarboxylation; antioxidant properties; reactive oxygen species; apoptosis; osteosarcoma

Online: 12 March 2021 (16:28:51 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0573.v1

Epidemiological and Microbiological Aspects of Health Care-associated Infections in Ukraine During the 2009–2019 Period

Yulian Konechnyi, Marta Panas, Iryna Tymchuk, Roksolana Konechna, Olena Borysiuk, Iryna Hubytska, Lesya Zhurakhivska, Olena Korniychuk

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: healthcare-associated infections; HCAIs; hospital acquired infections; nosocomial infections; statistical analysis

Online: 24 September 2020 (08:19:38 CEST)

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