Preprint Review Version 1 This version is not peer-reviewed

Neuron Cell Death

Version 1 : Received: 31 August 2018 / Approved: 31 August 2018 / Online: 31 August 2018 (05:56:58 CEST)

A peer-reviewed article of this Preprint also exists.

Chi, H.; Chang, H.-Y.; Sang, T.-K. Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases. Int. J. Mol. Sci. 2018, 19, 3082. Chi, H.; Chang, H.-Y.; Sang, T.-K. Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases. Int. J. Mol. Sci. 2018, 19, 3082.

Journal reference: Int. J. Mol. Sci. 2018, 19, 3082
DOI: 10.3390/ijms19103082

Abstract

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In physiological condition, neuronal cell death is restricted in the adult brain even as people ages. However, in pathological conditions of various neurodegenerative diseases, the cell death and shrinkage of a specific brain region represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe the evidence of the cell deaths in the context of common neurodegenerative diseases individually, discussing our current understandings of cell death in connecting with the renowned pathogenic proteins, including tau, amyloid-beta, alpha-synuclein, huntingtin, and TDP-43.

Subject Areas

apoptosis; necroptosis; neurodegeneration

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