Preprint Review Version 1 This version is not peer-reviewed

Dynamics of Bcl-2Protein Phosphorylation: A Mini Review

Version 1 : Received: 8 May 2020 / Approved: 9 May 2020 / Online: 9 May 2020 (08:40:40 CEST)

How to cite: Manan, A.; Ilyas, S. Dynamics of Bcl-2Protein Phosphorylation: A Mini Review. Preprints 2020, 2020050158 (doi: 10.20944/preprints202005.0158.v1). Manan, A.; Ilyas, S. Dynamics of Bcl-2Protein Phosphorylation: A Mini Review. Preprints 2020, 2020050158 (doi: 10.20944/preprints202005.0158.v1).

Abstract

The regulation of apoptosis depends upon the Bcl-2 protein family. The process of cell death and survival is highly complicated and regulated by various types of extrinsic as well as intrinsic network of biological system. Several enzymes and regulators play crucial role in cell death and survival cycle not only in healthy but also in pathological state particularly in cancer. In cancerous cells, various proto-oncogenes and anti-apoptotic proteins are activated and responsible for the cell survival and longevity. The mechanism of activation and inactivation of various proteins in cell survival is regulated by the process of phosphorylation (kinases) and dephosphorylation (phosphatases). The current review will summarize the dynamics of Bcl-2 phosphorylation and its role in apoptosis and cell survival.

Subject Areas

apoptosis; cancer; phosphorylation; kinases; Bcl-2

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