Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition

Takanori Eguchi; Kisho Ono; Stuart Calderwood; Kuniaki Okamoto

doi:10.20944/preprints201912.0386.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 28 December 2019 / Approved: 29 December 2019 / Online: 29 December 2019 (13:46:21 CET)

Extracellular vesicles (EVs), such as exosomes or oncosomes are released with molecules unfavorable for survival from cells. In addition, accumulating evidence has shown that tumor cells often eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing, drug resistance phenotype is often coupled with cellular dedifferentiation and transformation, cells undergoing epithelial-mesenchymal transition (EMT) and taking on a cancer stem cell phenotype. Recent studies have shown that the release of EVs is also involved in immunosuppression. The concept of the resistance-associated secretory phenotype (RASP) is reviewed herein.

resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology

MEDICINE & PHARMACOLOGY, Pharmacology & Toxicology

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Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition

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