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Preprint ARTICLE | doi:10.20944/preprints202007.0732.v1

On the Compactification and Reformation of String Theory with Three Large Atomic Gravitational Constants

Satya Seshavatharam U.V, Lakshminarayana S

Subject: Physical Sciences, Particle And Field Physics Keywords: String theory; Three atomic gravitational constants; 3+1 dimensions; 4G model of final unification; Microscopic Quantum Gravity;

Online: 31 July 2020 (05:17:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0270.v2

Improve the Three-phase Unbalance Rate of Railway System Under 2% By Three Kinds of Special Transformer Wiring

Chien-Hsu Chen, Chin E. Lin

Subject: Engineering, Electrical And Electronic Engineering Keywords: three-phase unbalance rate (TPUR); negative phase sequence unbalance rate (NPSUR); special transformer wiring (STW); Railway System Transport Cable (RSTC); Traction Supply Substation (TSS)

Online: 14 December 2021 (15:26:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0114.v1

Visualization of the Strain-rate State of a Data Cloud: Analysis of the Temporal Change of an Urban Multivariate Description

Lorena Salazar Llano, Camilo Bayona Roa

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: dimensionality reduction; pattern identification; three-dimensional data-cloud; strain-rate; Finite Element Method (FEM); trajectory visualization

Online: 13 June 2019 (08:18:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0399.v1

Non-Linear Reconstruction of Images from Patterns Generated by Deterministic or Random Optical Masks – Concepts and Review of Research

Daniel Smith, Shivasubramanian Gopinath, Francis Gracy Arockiaraj, Andra Naresh Kumar Reddy, Vinoth Balasubramani, Ravi Kumar, Nitin Dubey, Soon Hock Ng, Tomas Katkus, Shakina Jothi Selva, Dhanalakshmi Renganathan, Beaula Ruby Kamalam Manueldoss, Aravind Simon John Francis Rajeswary, Srinivasan Navaneethakrishnan, Stephen Rajkumar Inbanathan, Sandhra-Mirella Valdma, Praveen Periyasamy Angamuthu, Amudhavel Jayavel, Manoj Kumar, Rashid A Ganeev, Pierre J Magistretti, Christian Depeursinge, Saulius Juodkazis, Joseph Rosen, Vijayakumar Anand

Subject: Physical Sciences, Optics And Photonics Keywords: Holography; computational imaging; non-linear reconstruction; Fresnel incoherent correlation holography; coded aperture imaging; rotating point spread function; diffractive optics; scattering.

Online: 30 May 2022 (11:37:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0002.v1

Performance Study of Absorption Tower and Adsorption Reactor to Eliminate Ammonia Gas as Pollutant

Ikha Rasti Julia Sari, Januar Arif Fatkhurrahman, Yose Andriani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ammonia; emission control; saturation point; absorption tower; adsorption reactor

Online: 1 December 2021 (10:22:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0569.v1

Multiplex Recombinase Polymerase Amplification Assay for Simultaneous Detection of Treponema pallidum and Haemophilus ducreyi in yaws-like lesions

Michael Frimpong, Shirley Victoria Simpson, Hubert Senanu Ahor, Abigail Agbanyo, Solomon Gyabaah, Bernadette Agbavor, Ivy Brago Amanor, Kennedy Kwasi Addo, Susanne Böhlken-Fascher, Jonas Kissenkötter, Ahmed Abd El Wahed, Richard Odame Phillips

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Recombinase polymerase amplification; Treponema pallidum; Haemophilus ducreyi; Molecular diagnostics; Point-of-care test

Online: 26 August 2020 (09:01:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0262.v1

Reduction of DC-drift in LiNbO3-based Electro-optical Modulator

Aleksei V. Sosunov, Roman S. Ponomarev, Anton A. Zhuravlev, Sergey S. Mushinsky, Mariana Kuneva

Subject: Physical Sciences, Optics And Photonics Keywords: lithium niobate; electro-optical modulator; DC-drift; operating point

Online: 15 November 2021 (13:37:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0431.v1

Natural-Fibrous Lime-Based Mortar for the Rapid Retrofitting of Masonry Heritage

Marco Vailati, Micaela Mercuri, Michele Angiolilli, Amedeo Gregori

Subject: Engineering, Automotive Engineering Keywords: masonry; composite; short fibers; natural hydraulic lime; sisal; three-point bending test; fracture energy; strengthening; preservation; sustainability; carbon foot print

Online: 20 July 2021 (09:31:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0232.v1

The Stability of a General Sextic Functional Equation by Fixed Point Theory

Yang-Hi Lee, Soon-Mo Jung, Jaiok Roh

Subject: Computer Science And Mathematics, Analysis Keywords: sextic mapping; general sextic functional equation; fixed point theory method; generalized Hyers-Ulam stability

Online: 21 January 2020 (06:41:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0285.v1

Inter-rater Variability in the Evaluation of Lung Ultrasound on Videos Acquired from COVID-19 Patients

Joaquin L. Herraiz, Clara Freijo, Jorge Camacho, Mario Muñoz, Ricardo González, Rafael Alonso-Roca, Jorge Álvarez-Troncoso, Luis Matías Beltrán-Romero, Máximo Bernabeu-Wittel, Rafael Blancas, Antonio Calvo-Cebrián, Ricardo Campo-Linares, Jaldún Chehayeb-Morán, Jose Chorda-Ribelles, Samuel García-Rubio, Gonzalo García-de-Casasola, Adriana Gil-Rodrigo, César Henríquez-Camacho, Alba Hernandez-Píriz, Carlos Hernandez-Quiles, Rafael Llamas-Fuentes, Davide Luordo, Raquel Marín-Baselga, María Cristina Martínez-Díaz, María Mateos-González, Manuel Mendez-Bailon, Francisco Miralles-Aguiar, Ramón Nogue, Marta Nogué, Borja Ortiz de Urbina-Antia, Alberto Ángel Oviedo-García, José M. Porcel, Santiago Rodriguez, Diego Aníbal Rodríguez-Serrano, Talía Sainz, Ignacio Manuel Sánchez-Barrancos, Marta Torres-Arrese, Juan Torres-Macho, Ángela Trueba-Vicente, Tomas Villen-Villegas, Juan José Zafra-Sánchez, Yale Tung-Chen

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Coronavirus disease 2019; interobserver agreement; interrater reliability; lung ultrasound; point-of-care ultrasound; reliability; severe acute respiratory syndrome; ultrasound

Online: 15 November 2022 (09:57:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0418.v1

Mapping Vegetation at Species Level with High-Resolution Multispectral and Lidar Data over Large Spatial Area: A Case Study with Kudzu

Wanwan Liang, Mongi Abidi, Luis Carrasco, Jack McNelis, Liem Tran, Yingkui Li, Jerome Grant

Subject: Environmental And Earth Sciences, Environmental Science Keywords: detailed vegetation mapping; kudzu mapping; coarse label; two-step classification; object-based image analysis; lidar point clouds; sampling specificity

Online: 31 December 2019 (16:58:25 CET)

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Mapping vegetation species is critical to facilitate related quantitative assessment, and for invasive plants mapping their distribution is important to enhance monitoring and controlling activities. Integrating high resolution multispectral remote sensing (RS) image and lidar (light detection and ranging) point clouds can provide robust features for vegetation mapping. However, using multiple source of high-resolution RS data for vegetation mapping at large spatial scale can be both computationally and sampling intensive. Here we designed a two-step classification workflow to decrease computational cost and sampling effort, and to increase classification accuracy by integrating multispectral and lidar data to derive spectral, textural, and structural features for mapping target vegetation species. We used this workflow to classify kudzu, an aggressive invasive vine, in the entire Knox County (1,362 km2) of Tennessee, the United States. Object-based image analysis was conducted in the workflow. The first-step classification used 320 kudzu samples and extensive coarsely labeled samples (based on national land cover) to generate an overprediction map of kudzu using random forest (RF). For the second step, 350 samples were randomly extracted from the overpredicted kudzu and labeled manually for the final prediction using RF and support vector machine (SVM). Computationally intensive features were only used for the second-step classification. SVM had constantly better accuracy than RF, and the Producer’s Accuracy, User’s Accuracy, and Kappa for the SVM model on kudzu was 0.94, 0.96, and 0.90, respectively. SVM predicted 1010 kudzu patches covering 1.29 km2 in Knox County. We found the sample size of kudzu used for algorithm training impacted the accuracy and number of kudzu predicted. The proposed workflow could also improve sampling efficiency and specificity. Our workflow had much higher accuracy than the traditional method conducted in this research, and could be easily implemented to map kudzu in other regions or other vegetation species.

Preprint ARTICLE | doi:10.20944/preprints201811.0361.v1

3D Scattering Imaging of Multiscale Geological Media on the Base of Revised Version of Exploding Reflectors

Evgeny Landa, Galina Reshetova, Vladimir Tcheverda

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Common Middle Point; Propagator; Spatial Reflector; small-scale heterogeneities; diffraction/scattering imaging; finite-difference simulation; local grid refinement in time and space.

Online: 15 November 2018 (11:18:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201811.0630.v1

Explaining Defects of the Universal Vacua with Black Holes-Hedgehogs and Strings

C.R. Das, L.V. Laperashvili, H.B. Nielsen, B.G. Sidharth

Subject: Physical Sciences, Particle And Field Physics Keywords: hedgehogs; topological defects; multiple point principle

Online: 30 November 2018 (10:23:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0278.v1

Usefulness of Multi-Organ Point-Of-Care Ultrasound as a Complement to the Decision-Making Process in Internal Medicine

Irene Casado-López, Yale Tung-Chen, Marta Torres-Arrese, Davide Luordo-Tedesco, Arantzazu Mata-Martínez, Jose Manuel Casas-Rojo, Esther Montero-Hernández, Gonzalo García De Casasola-Sánchez

Subject: Medicine And Pharmacology, Internal Medicine Keywords: point-of-care ultrasound; internal medicine; lung ultrasound; echocardiography; abdominal ultrasound

Online: 21 March 2022 (08:39:57 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202104.0641.v1

Three-Dimensional Laser Scanning-Based Method for Identifying Rock Discontinuities

Shengming Hu, Gao Jianglin, liang Hu, Zhiguang Dai, Fang Chen

Subject: Engineering, Automotive Engineering Keywords: three-dimensional laser scanning; rock discontinuity; rock fracture; rock joint; discontinuity orientation.

Online: 23 April 2021 (13:15:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0696.v1

A Novel Grid-Based Data Broadcasting Scheme for Wireless Sensor Networks

Arpit Bhushan Sharma, Harshit Kargeti

Subject: Engineering, Electrical And Electronic Engineering Keywords: dissemination node; reference coordinates; crossing point; residual energy; sink manager

Online: 29 July 2020 (12:28:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0371.v1

Knockout of MMP3 Weakened Solid Tumor Organoids and Cancer Extracellular Vesicles

Eman A. Taha, Chiharu Sogawa, Yuka Okusha, Hotaka Kawai, May Wathone Oo, Abdellatif El-Seoudi, Yanyin Lu, Hitoshi Nagatsuka, Satoshi Kubota, Ayano Satoh, Kuniaki Okamoto, Takanori Eguchi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: matrix metalloproteinase 3 (MMP3); extracellular vesicles (EVs); tumoroid; tumor organoid; tumorigenesis; three-dimensional (3D) culture system

Online: 25 March 2020 (05:25:09 CET)

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The tumor organoid (tumoroid) model in three-dimensional (3D) culture systems has been developed to reflect more closely the in vivo tumors than 2D-cultured tumor cells. Notably, extracellular vesicles (EVs) are efficiently collectible from the culture supernatant of gel-free tumoroids. Matrix metalloproteinase (MMP) 3 is a multi-functional factor playing crucial roles in tumor progression. However, roles of MMP3 within tumor growth and EVs have not unveiled. Here, we investigated the protumorigenic roles of MMP3 on integrities of tumoroids and EVs. We generated MMP3-knockout (KO) cells using the CRISPR/Cas9 system from rapidly metastatic LuM1 tumor cells. Moreover, we established fluorescent cell lines with palmitoylation signal-fused fluorescent proteins (tdTomato and enhanced GFP). Then we confirmed the exchange of EVs between cellular populations and tumoroids. LuM1-tumoroids released large EVs (300-1000 nm) and small EVs (50-200 nm) while the knockout of MMP3 resulted in the additional release of broken EVs from tumoroids. The loss of MMP3 leads to a significant reduction in tumoroid size and to the development of the necrotic area within tumoroids. MMP3 and CD9 (a category-1 EV marker tetraspanin protein) were significantly down-regulated in MMP3-KO cells and their EV fraction. These weakened phenotypes by MMP3 KO were markedly rescued by the addition of MMP3-rich EVs or conditioned medium (CM) collected from LuM1-tumoroids, which caused a dramatic rise in the expression of MMP3, CD9, and Ki-67 (a marker of proliferating cells) in the MMP3-null/CD9-low tumoroids. Notably, MMP3 enriched in tumoroids-derived EVs and CM deeply penetrated into recipient MMP3-KO tumoroids, resulting in a remarkable enlargement of solid tumoroids, while MMP3-null EVs did not. These data demonstrate that EVs can mediate molecular transfer of MMP3 resulting in increasing the proliferation and CD9+ tumorigenesis, indicating crucial roles of MMP3 in tumor progression.

Preprint ARTICLE | doi:10.20944/preprints202012.0124.v1

Vectorial Variational Inequalities on Hadamard Manifolds: A Tool to Achieve Efficient Approximate Solutions

Gabriel Ruiz-Garzón, Rafaela Osuna-Gómez, Antonio Rufián-Lizana, Beatriz Hernández-Jiménez

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Generalized convexity; Hadamard manifold; Approximate efficient solution; Stackelberg equilibrium point

Online: 7 December 2020 (07:09:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0126.v1

Roach Infestation Optimization MPPT Algorithm for Solar Photovoltaic System

Chittaranjan Pradhan, Nicholas Kakra Ntiakoh, Rajnish Kaur Calay

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC-DC Boost converter; Maximum power point tracking (MPPT); Partial shading condition (PSC); Particle swam optimization (PSO); Roach infestation optimization (RIO); Solar photovoltaic system

Online: 9 February 2022 (07:59:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0642.v1

PointBLIP: Zero-Training Point Cloud Classification Network Based on BLIP-2 Model

Yunzhe Xiao, Yong Dou, Shaowu Yang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: point cloud classification; zero-training; large-scale vision-and-language model; zero-shot classification; few-shot classification

Online: 8 January 2024 (17:03:40 CET)

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Working Paper ARTICLE

Systematic Assessment of Burst Impurity in Confocal-Based Single-Molecule Fluorescence Detection Using Brownian Motion Simulations

Dolev Hagai, Eitan Lerner

Subject: Biology And Life Sciences, Biophysics Keywords: single-molecule; fluorescence; burst; photon rate; effective detection volume; point-spread function; Brownian; diffusion; simulation; threshold.

Online: 8 July 2019 (14:55:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0448.v1

The Impact of Event Scale – Revised: Examining its cutoff scores among Arab psychiatric patients and healthy adults within the context of COVID-19 as a collective traumatic event

Amira M. Ali, Saeed Abdullah Al-Dossary, Abdulaziz Mofdy Almarwani, Maha Atout, Rasmieh Al-Amer, And Abdulmajeed A. Alkhamees

Subject: Social Sciences, Psychology Keywords: Impact of Event Scale-Revised (IES-R)/post-traumatic stress disorder (PTSD); cutoff point/cutoff score; psychiatric patients/the general public/healthy adults; psychometric evaluation/criterion validity; Coronavirus Disease-19/COVID-19; Arabic version/Arab/Saudi Arabia

Online: 25 January 2023 (05:02:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0500.v1

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Jessica Panes, Thi Kim Oanh Nguyen, Huanyao Gao, Trace A Christensen, Andrea Stojakovic, Sergey Trushin, Jeffrey L Salisbury, Jorge Fuentealba, Eugenia Trushina

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s Disease (AD) mitochondria; endoplasmic reticulum (ER); serial block-face scanning electron microscopy (SBFSEM); three-dimensional electron microscopy (3D EM); small molecule mitochondria targeted therapeutics

Online: 27 January 2023 (10:08:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0015.v1

Three Doses of COVID-19 Vaccines: A Retrospective Study Evaluating the Safety and the Immune Response in Patients with Multiple Sclerosis

Giorgia Teresa Maniscalco, Daniele Di Giulio Cesare, Valerio Liguori, Valentino Manzo, Elio Prestipino, Simona Salvatore, Maria Elena Di Battista, Ornella Moreggia, Antonio Rosario Ziello, Vincenzo Andreone, Cristina Scavone, Annalisa Capuano

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; mRNA-based vaccine; safety; multiple sclerosis; AEFI; observational study; three doses

Online: 1 June 2023 (03:37:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0192.v1

Using Enhanced Sparrow Search Algorithm-Deep Extreme Learning Machine Model to Forecast End-Point Phosphorus Content of BOF

Lingxiang Quan, Ailian Li, Guimei Cui, Shaofeng Xie

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: End-point phosphorus content; Deep extreme learning machine; Sparrow search algorithm; Trigonometric substitution; Cauchy mutation

Online: 10 December 2021 (15:04:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0287.v1

Accounting for Wood, Foliage Properties and Laser Effective Footprint in Estimations of Leaf Area Density from multiview-LiDAR Data

Francois Pimont, Maxime Soma, Jean-Luc Dupuy

Subject: Environmental And Earth Sciences, Environmental Science Keywords: bias; efficiency; element size; LAD; LAI; leaf and wood separation; LiDAR; multiple viewpoints; point cloud; TLS; UAV; voxel

Online: 24 May 2019 (07:53:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1207.v1

The Prospect and Application Research Progress of Precision Gene Editing Technology Based on CRISPR/Cas9 in Livestock Genetics and Breeding

Zeyu Lu, Lingtian Zhang, Qing Mu, Junyang Liu, Yu Chen, Haoyuan Wang, Yanjun Zhang, Rui Su, Ruijun Wang, Zhiying Wang, Qi Lv, Zhihong Liu, Jiasen Liu, Yunhua Li, Yanhong Zhao

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Precision gene editing; CRISPR/Cas9; Livestock genetic breeding; Cashmere goat; Editing efficiency; Fixed point integration

Online: 15 December 2023 (16:46:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0219.v1

Unveiling the Hidden Rules of Spherical Viruses Using Point Arrays

David Wilson

Subject: Biology And Life Sciences, Virology Keywords: protruding features; spherical virus; point arrays; surface modifications; VLP; drug delivery; icosahedral; nanomedicine; ligand binding

Online: 20 January 2020 (06:59:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0078.v1

Modeling Insolation, Multi-spectral Imagery and LiDAR Point-cloud Metrics to Predict Plant Diversity in a Temperate Montane Forest

Paul Christian Dunn, Leonhard Blesius

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: biodiversity; insolation, biogeography; lidar; point-cloud; multi-spectral imagery; spatial prediction model; forest canopy

Online: 3 August 2021 (13:05:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0340.v2

Wire Ropes and CFRP Strips to Provide the Masonry Walls with Out-of-Plane Strengthening

Elena Ferretti

Subject: Engineering, Civil Engineering Keywords: masonry buildings; hammering actions; out-of-plane strengthening; three-dimensional strengthening systems; CFRP strips; textile reinforced mortar (TRM)

Online: 26 August 2019 (09:03:00 CEST)

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The present paper deals with an improvement of the strengthening technique consisting in the combined use of straps—made of stainless steel ribbons—and CFRP strips, to increase the out-of-plane strength of masonry walls. The straps of both the previous and the new combined technique pass from one face to the opposite face of the masonry wall through some holes made along the thickness, giving rise to a three-dimensional net of loop-shaped straps, closed on themselves. The new technique replaces the stainless steel ribbons with steel wire ropes, which form closed loops around the masonry units and the CFRP strips as in the previous technique. A turnbuckle for each steel wire rope allows the closure of the loops and provides the desired pre-tension to the straps. The mechanical coupling—given by the frictional forces—between the straps and the CFRP strips placed on the two faces of the masonry wall gives rise to an I-beam behavior of the facing CFRP strips, which begin to resist the load as if they were the two flanges of the same I-beam. Even the previous combined technique exploits the ideal I-beam mechanism, but the greater stiffness of the steel wire ropes compared to the stiffness of the steel ribbons makes the constraint between the facing CFRP strips stiffer. This gives the reinforced structural element greater stiffness and delamination load. In particular, the experimental results show that the maximum load achievable with the second combined technique is much greater than the maximum load provided by the CFRP strips. Even the ultimate displacement turns out to be increased, allowing us to state that the second combined technique improves both strength and ductility. Since the CFRP strips of the combined technique run along the vertical direction of the wall, the ideal I-beam mechanism is particularly useful to counteract the hammering actions provided by the floors on the perimeter walls, during an earthquake. Lastly, after the building went out of service, the box-type behavior offered by the three-dimensional net of straps prevents the building from collapsing, acting as a device for safeguarding life.

Preprint REVIEW | doi:10.20944/preprints202307.1536.v1

Electrochemical vs Optical Biosensors for Point of Care Applications: A Critical Review

Seyedeh Rojin Shariati Pour, Donato Calabria, Afsaneh Emamiamin, Elisa Lazzarini, Andrea Pace, Massimo Guardigli, Martina Zangheri, Mara Mirasoli

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Optical detection; Point-of-care; Lab-On-Chip; Microfluidic device; Paper-based device; Biosensor; Electrochemical detection

Online: 24 July 2023 (02:24:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0202.v1

Implants versus Lipograft – Analysis of Long-Term Results after Congenital Breast Asymmetry Procedure

Vanessa Brebant, Maximilian Weiherer, Vivien Noisser, Stephan Seitz, Lukas Prantl, Andreas Eigenberger

Subject: Medicine And Pharmacology, Surgery Keywords: congenital breast asymmetry; PROM, autologous fat injections, fat grafting, lipograft, implant augmentation, breast augmentation, 3D volumetry, three-dimensional imaging, Breast-QTM; human adipose stem cells

Online: 9 August 2021 (15:06:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0106.v1

Tightly Coupled Ultra-Wideband Phased-Array Implemented by Three-Dimensional Inkjet Printing Technique

Lei Han, Gang Wang, Lin Zhang, Weixu Jiang, Pengbing Zhao, Wei Tang, Tao Dang, Hongxing Zheng

Subject: Engineering, Electrical And Electronic Engineering Keywords: Ultra-wideband; conformal antenna array; coupled tightly; three-dimensional printing technique; fused deposition modelling; microdroplet injection molding

Online: 7 September 2022 (08:15:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0266.v1

Pan-Cancer Integrative Analysis of Whole-Genome De novo Somatic Point Mutations Reveals 17 Cancer Types

Amirreza Kazemi, Amin Ghareyazi, Kimia Hamidieh, Hamed Dashti, Maedeh Tahaei, Hamid Rabiee, Hamid Alinejad Rokny, Abdollah Dehzangi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pan-Cancer; somatic point mutations; cancer subtyping; biomarker discovery; driver genes; per-sonalized medicine; health data analytics

Online: 15 November 2021 (13:51:33 CET)

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The advent of high throughput sequencing has enabled researchers to systematically evaluate the genetic variations in cancer, resulting in identifying many cancer-associated genes. Although cancers in the same tissue are widely categorized in the same group, they demonstrate many differences concerning their mutational profiles. Hence there is no “silver bullet” for the treatment of a cancer type. This reveals the importance of developing a pipeline to identify cancer-associated genes accurately and re-classify patients with similar mutational profiles. Classification of cancer patients with similar mutational profiles may help discover subtypes of cancer patients who might benefit from specific treatment types. In this study, we propose a new machine learning pipeline to identify protein-coding genes mutated in a significant portion of samples to identify cancer subtypes. We applied our pipeline to 12270 samples collected from the International Cancer Genome Consortium (ICGC), covering 19 cancer types. Here we identified 17 different cancer subtypes. Comprehensive phenotypic and genotypic analysis indicates distinguishable properties, including unique cancer-related signaling pathways, in which, for most of them, targeted treatment options are currently available. This new subtyping approach offers a novel opportunity for cancer drug development based on the mutational profile of patients. We also comprehensive study the causes of mutations among samples in each subtype by mining the mutational signatures, which provides important insight into their active molecular mechanisms. Some of the pathways we identified in most subtypes, including the cell cycle and the Axon guidance pathways, are frequently observed in cancer disease. Interestingly, we also identified several mutated genes and different rates of mutation in multiple cancer subtypes. In addition, our study on “gene-motif” suggests the importance of considering both the context of the mutations and mutational processes in identifying cancer-associated genes. The source codes for our proposed clustering pipeline and analysis are publicly available at: https://github.com/bcb-sut/Pan-Cancer.

Preprint TECHNICAL NOTE | doi:10.20944/preprints202010.0340.v1

Coupling and Recoupling of Binaries in Chaotic Three-Body Systems

T.S. Sachin Venkatesh

Subject: Physical Sciences, Acoustics Keywords: celestial mechanics; three-body problem; gravitational interaction; chaos; orbits; astronomical simulations

Online: 16 October 2020 (08:25:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0375.v1

Rapid Detection of Anti-SARS-CoV-2 Antibodies With a Screen-Printed Electrode Modified With a Spike Glycoprotein Epitope

Wiilson Ameku, David Provance, Carlos Morel, Salvatore De-Simone

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; spike glycoprotein; epitope; electrochemical biosensor; point of care; immunological diagnostic

Online: 29 March 2022 (08:39:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0644.v1

Novel Method to Analytically Obtain the Asymptotic Stable Equilibria States of Extended SIR-type Epidemiological Models

Teddy Lazebnik, Svetlana Bunimovich-Mendrazitsky, Leonid Shaikhet

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Markov chain; random variable transformation technique; asymptotic stable equilibria state; three age group SIIRD model

Online: 26 May 2021 (14:29:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0086.v1

Rapid and Sensitive Point of Care Detection of MRSA gDNA by Nanoelectrokinetic Sensors

Rania Oueslati, Yu Jiang, Jiangang Chen, Jie Jayne Wu

Subject: Engineering, Electrical And Electronic Engineering Keywords: DNA sensor; point of care diagnostics; methicillin-resistant Staphylococcus aureus; label free biosensor; AC electrokicetics

Online: 5 April 2021 (10:11:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0339.v1

Optimizing Public Health Preparedness for Highly Infectious Diseases in Central Vietnam

Amanullah Zadran, An V.D. Ho, Layma Zadran, Irene J Ventura Curiel, Tang-Tung Pham, Duong Thi Bich Thuan, Gerald J Kost

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Infectious disease testing; public health preparedness; point-of-care testing (POCT); molecular diagnostics; therapeutic turnaround time (TTAT); acute medical challenges; geographic information systems; antimicrobial stewardship

Online: 22 July 2022 (13:13:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0368.v1

An Investigation of Point Mutations Discovers Novel Genes and Their Corresponding Motifs in Pancreatic Cancer

Amin Ghareyazi, Amir Mohseni, Hamed Dashti, Abdollah Dehzangi, Hamid R. Rabiee, Hamid Alinejad-Rokny

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pancreatic cancer; cancer subtype identification; somatic point mutations; genotype and phenotype characterization; therapeutic targets; personalized medicine

Online: 17 August 2021 (22:24:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0109.v1

Moving Object Detection Based on a Combination of Kalman Filter and Median Filtering

Diana Kalita, Pavel Lyakhov

Subject: Computer Science And Mathematics, Information Systems Keywords: Kalman filter; median filter; impulse noise; estimate prediction; object distance determination; lidar; value calibration; point cloud.

Online: 7 September 2022 (10:20:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0438.v1

A Novel Method to Generate Auto-Labeled Datasets for 3D Vehicle Identification Using a New Contrast Model

Guillermo S Gutierrez-Cabello, Edgar Talavera, Miguel Clavijo, Guillermo Iglesias, Felipe Jimenez

Subject: Engineering, Automotive Engineering Keywords: Auto-labeled; LiDAR, Point of View, Deep Learning

Online: 27 February 2023 (04:12:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0086.v1

Monolithic Solvers for Incompressible Two-Phase Flows at Large Density and Viscosity Ratios

Mohamed EL OUAFA, stephane vincent, Vincent Le Chenadec

Subject: Engineering, Automotive Engineering Keywords: Velocity–pressure coupling; Fully coupled solvers; Augmented Lagrangian; two-phase flows; saddle point; projection method; preconditioning; smooth VOF

Online: 3 December 2020 (13:50:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0039.v1

A New R Package for Categorizing Coding and Non-Coding Genes

Masroor Bayati, Narges Rezaie, Mehrab Hamidi, Maedeh Sadat Tahaei, Hamid Rabiee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: somatic point mutations; non-coding RNA; biomarker discovery; driver genes; non-coding RNAs prioritization; health data analytics

Online: 4 January 2023 (02:22:00 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202108.0118.v1

The Amoebic Self Scale and GPA are related to the academic procrastination sensu lato

Ernest Bielinis, Lidia Bielinis

Subject: Social Sciences, Education Keywords: active procrastination; amoebic self-theory; correlation; grade point average; procrastination; procrastination sensu lato

Online: 4 August 2021 (14:56:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0272.v1

Remaining Useful Life Prediction from 3D Scan Data with Genetically Optimized Convolutional Neural Networks

Giovanni Diraco, Pietro Siciliano, Alessandro Leone

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Remaining Useful Life; Deep Neural Network; Convolutional Neural Network; Genetic Optimization; Neural Network Optimization; Support Vector Regression; Depth Maps; Normal Maps; 3D Point Clouds.

Online: 12 August 2021 (10:40:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0343.v1

An Integrative Analysis of Chromatin Interactions, Gene Expression and Genomic Variants Identifies 30 Likely Regulatory Variants in Prostate Cancer

Mahdieh Labani, Amin Beheshti, Ahmadreza Argha, Hamid Alinejad

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Prostate cancer; Somatic point mutations; Copy number variation; Regulatory variant, Hi-C; Per-sonalized medicine; Biomedical machine learning

Online: 19 January 2023 (02:10:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0112.v1

Contrasitive Learning for 3D Point Clouds Classification and Shape Completion

Danish Nazir, Muhammad Zeshan Afzal, Alain Pagani, Marcus Liwicki, Didier Stricker

Subject: Engineering, Marine Engineering Keywords: 3D point Cloud Classification, 3D point Cloud Shape Completion,Auto-Encoders, Contrastive Learning, Self-Supervised Learning

Online: 6 September 2021 (18:00:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0316.v1

Multi-Scale Model Crack Extension Study Based on XFEM

Guangzhong Liu, Zezhu Chen

Subject: Engineering, Marine Engineering Keywords: Extend the finite element; multi-point constraint; ship crack

Online: 13 April 2023 (08:59:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0029.v1

θ∗-Weak Contractions and Discontinuity at the Fixed Point With Applications to Matrix and Integral Equations

Atiya Perveen, Waleed Alfaqih, Salvatore Sessa, Mohammad Imdad

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: θ∗-weak contraction; fixed point; discontinuity at the fixed point; property P; matrix equation; integral equations

Online: 2 August 2021 (12:21:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0277.v6

Stability Analysis of Nontrivial Stationary Solution and Constant Equilibrium Point of Reaction-Diffusion Neural Networks with Time Delays under Dirichlet Zero Boundary Value

Ruofeng Rao

Subject: Computer Science And Mathematics, Mathematics Keywords: reaction-diffusion; cellular neural networks; exponential stability; stationary solutions; Saddle point theorem

Online: 2 October 2020 (13:57:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0715.v1

Experimental Study on the Fracture Parameters of Concrete

Zhanqiao Wang, Jin Gou, Danying Gao

Subject: Chemistry And Materials Science, Biomaterials Keywords: steel fiber; three-point bending; fracture parameters; gain ratio

Online: 30 November 2020 (10:58:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1037.v1

Evaluation of Standard M10 Assay for Rapid Molecular Diagnosis of SARS-CoV-2, Influenza A/B virus and Respiratory Syncytial Virus (RSV)

Azwani Abdullah, I-Ching Sam, Yin Jie Ong, Chun Hao Theo, Muhammad Harith Pukhari, Yoke Fun Chan

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: respiratory syncytial virus; influenza A virus; influenza B virus; SARS-CoV-2; rapid RT-PCR; diagnostic accuracy; point-of-care testing

Online: 15 September 2023 (05:38:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0161.v1

Understanding the Nature of the Long–Range Memory Phenomenon in Socio–Economic Systems

Rytis Kazakevičius, Aleksejus Kononovicius, Bronislovas Kaulakys, Vygintas Gontis

Subject: Physical Sciences, Condensed Matter Physics Keywords: long–range memory; 1/f noise; absolute value estimator; anomalous diffusion; ARFIMA; first–passage times; fractional Lèvy stable motion; Higuchi’s method; Mean squared displacement; multiplicative point process

Online: 6 August 2021 (11:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0314.v1

Evaluation of Different Cannulation Strategies for Aortic Arch Surgery Using a Cardiovascular Numerical Simulator

Beatrice De Lazzari, Massimo Capoccia, Roberto Badagliacca, Claudio De Lazzari

Subject: Medicine And Pharmacology, Surgery Keywords: Aortic surgery; Aortic arch; Three-way cannulation approach; Carotid artery perfusion; Pressure-volume loop; Lumped parameter model; Software simulation; Cardiovascular modelling.; CARDIOSIM

Online: 20 October 2022 (14:19:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0484.v1

Ekeland Variational Principle and Some of Its Equivalents on a Weighted Graph, Completeness and the Osc Property

Ali Basit, Stefan Cobzas, Mokhwetha Daniel Mabula

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Ekeland variational principle; Takahashi minimization principle; Caristi fixed point theorem; weighted graph; partially ordered metric space; completeness; the OSC property

Online: 26 January 2023 (17:12:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0421.v1

Unveiling the Different Reactivity of Bent and Linear Three-Atom-Components Participating in [3+2] Cycloaddition Reactions

Mar Ríos-Gutiérrez, Luis R. Domingo, Fatemeh Ghodsi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: [3+2] cycloaddition reactions; bent and linear three-atom-components; reactivity; regioselectivity; molecular electron density theory

Online: 18 May 2021 (11:19:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0360.v1

Separation Axioms Interval-Valued Fuzzy Soft Topology via Quasi-Neighbourhood Structure

Mabruka Ali, Adem Kılıçman, Azadeh Zahedi Khameneh

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: interval-valued fuzzy soft set; interval-valued fuzzy soft topology; interval-valued fuzzy soft point; interval-valued fuzzy soft neighborhood; interval-valued fuzzy soft quasi-neighbourhood; interva

Online: 27 December 2019 (08:44:19 CET)

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Working Paper REVIEW

C,C- and C,N-Chelated Organocopper Compounds

Liang Liu, Hui Chen, Zhenqiang Yang, Junnian Wei, Zhenfeng Xi

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: organocopper; C,N-chelated; C,C-chelated; bidentate; butadienyl; intramolecular coordination; three center-two electron bonds; structure-reactivity relationship

Online: 2 September 2021 (12:01:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0440.v1

Implementation of Antimicrobial Stewardship in a District Hospital in the Ashanti Region of Ghana Using a Health Partnership Model

Obed Kwabena Offe Amponsah, Aaron J. Courtenay, Ahmed Abuelhana, Nana Kwame Ayisi-Boateng, Douglas Anning Opoku, Lawrence Kobbina Blay, Nana Akua Abruquah, Annabella Bensusan Osafo, Charlotte Boachie Danquah, Phyllis Tawiah, Mercy Naa Aduele Opare-Addo, Alex Owusu-Ofori, Kwame Ohene Buabeng

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Antimicrobial stewardship; Point prevalence survey; Antimicrobial resistance; Ghana; CwPAMS; Antibiotic use; THET

Online: 23 December 2022 (03:53:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0517.v1

New Study of Existence and Dimension of the Set of Solutions for Nonlocal Impulsive Differential Inclusions With Sectorial Operator

Salvatore Sessa, Nawal Alsarori, Kirtiwant Ghadle, Hayel Saleh

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Impulsive fractional differential inclusions; Nonlocal conditions; Fixed point theorems; 10 Mild solutions

Online: 23 February 2021 (14:16:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0597.v1

Existence and Uniquenes Solution of Integral Equations via Common Fixed Point Theorems

Gunaseelan Mani, Arul Joseph Gnanaprakasam, Yongjin Li, Zhaohui Gu

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: integral equations; complex partial metric space; common fixed point.

Online: 22 April 2021 (09:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0368.v1

A 3DCNN-LSTM Multi-Class Temporal Segmentation for Hand Gesture Recognition

Letizia Gionfrida, Wan M.R. Rusli, Angela E. Kedgley, Anil A. Bharath

Subject: Computer Science And Mathematics, Computer Science Keywords: hand gesture classification; transfer learning; three-dimensional convolutional; LSTM network

Online: 27 June 2022 (13:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0489.v1

Nighttime Sleep Awakening Frequency and Its Consistency Predict Future Academic Performance in College Students

Ghee Wee Ho, Zhenzhi Yang, Linna Xing, Ken Kang-Too Tsang, Huada Daniel Ruan, Yu Li

Subject: Social Sciences, Psychology Keywords: sleep; academic performance; grade point average; college students; wearable device; longitudinal; nighttime sleep awakening

Online: 30 December 2021 (13:45:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0038.v1

Minimalised Three-Dimensional Human Midbrain In Vitro Model for Neurotoxicity Evaluation of DYRK1 Inhibitors

Xiao Wan, Vincent Fagan, Paul Brennan, Daniel Ebner

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: three-dimensional in vitro model; DYRK1; human midbrain; neural progenitor cells

Online: 5 October 2022 (11:29:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0046.v1

New Fixed Point Results via (q,y)R-Weak Contractions with an Application

Mohammad Imded, Based Ali, Waleed M. Alfaqih, Salvatore Sessa

Subject: Computer Science And Mathematics, Mathematics Keywords: fixed point; q-contraction; binary relation; integral equation

Online: 4 May 2020 (02:54:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0249.v1

Predictive Model of ACC Speed to Enhance Engine Operating Conditions

Srikanth Kolachalama, Hafiz Malik

Subject: Engineering, Automotive Engineering Keywords: Adaptive Cruise Control; Driver behvaiour; Deep learning; Engine Operating Point; NARX

Online: 18 October 2021 (14:48:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0838.v1

Smartphone- and Cloud-based Artificial Intelligence Quantitative Analysis System (SCAISY) for SARS-CoV-2-specific IgG Antibody Lateral Flow Assays

Samir Kumar, Taewoo Ko, Yeonghun Chae, Ahyeon Lee, Sanghoon Shin, Myung-Hyun Nam, Byung Soo Kim, Hyun Sik Jun, Sungkyu Seo

Subject: Engineering, Bioengineering Keywords: Smartphone; Point-of-care testing; Lateral flow assay; Artificial intelligence; SARS-CoV-2; IgG antibody

Online: 24 April 2023 (09:17:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0477.v1

LiDAR and UAV SfM-MVS of Merapi Volcanic Dome And Crater Rim Change from 2012 to 2014

Christopher Gomez, Franck Lavigne, Noviyanti Listyaningrum, Sandy Budi Wibowo, Danang Sri Hadmoko, Wiwit Suryanto, Herlan Darmawan, Balazs Bradak, Rikuto Daikai, Sunardi Sunardi, Yudo Prasetyo, Annisa Joviani Astari, Lukman Lukman, Idea Wening Nurani, Moh. Dede, Indranova Suhendro

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Merapi Volcano; Indonesia; Natural Hazards; Disaster Risk and Point-cloud technology

Online: 29 August 2022 (08:34:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0424.v1

Microfluidic Lab-On-a-Chip based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells

Elisa Lambert, Rémi Manczak, Elodie Barthout, Sofiane Saada, Elena Porcù, Francesca Maule, Barbara BESSETTE, Giampietro Viola, Luca Persano, Claire DALMAY, Fabrice Lalloué, Arnaud POTHIER

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: high frequency dielectrophoresis; glioblastoma cells; single cell manipulation; microfluidic point-of-care device; cancer stem cells

Online: 24 September 2021 (11:11:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0197.v1

Stability and Stabilization of Ecosystem for Epidemic Virus Transmission Under Neumann Boundary Value Via Impulse Control

Ruofeng Rao

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Neumann boundary value; positive equilibrium point; Poincare inequality lemma; impulse control

Online: 8 February 2021 (12:05:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0349.v1

Using Various Analysis Center Products to Assess the Time-Frequency Transfer Performance of GPS/Galileo/BDS PPPAR Methods

Mingjun OuYang, Xiangwei Zhu, Ruite Yi, Daqian Lyu

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: Time Frequency Transfer; Precise Point Positioning; Ambiguity Resolution (AR); Analysis Center (AC)

Online: 24 October 2022 (05:33:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0646.v2

Constraints on General Relativity Geodesics by a Covariant Geometric Uncertainty Principle

David Escors, Grazyna Kochan

Subject: Physical Sciences, Quantum Science And Technology Keywords: General relativity; Uncertainty principle; Geodesics; Black hole singularity; zero-point energy

Online: 2 August 2021 (13:38:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0300.v1

Multi-View and Shift Rasterization Algorithm (MVSR) for Effective Identification of Ground in Dense Point Clouds

Martin Štroner, Rudolf Urban, Lenka Línková

Subject: Engineering, Control And Systems Engineering Keywords: Point cloud; Ground filtering; Classification

Online: 22 June 2022 (03:37:45 CEST)

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With the ever-increasing popularity of unmanned aerial vehicles and other platforms providing dense point clouds, universal filters for accurate identification of ground points in such dense clouds are needed. Many filters have been proposed and are widely used, usually based on the determination of an original surface approximation and subsequent identification of points within a predefined distance from such surface. In this paper, we present a new filter. This Multi-view and shift rasterization algorithm (MVSR) is based on an entirely different principle, i.e., on the identification of just the lowest points in individual grid cells, shifting the grid along both planar axis and subsequent tilting of the entire grid – after each of these steps, one lowest point per cell is detected. The principle is presented in detail and compared both visually and numerically to other commonly used ground filters (PMF, SMRF, CSF, ATIN) on three sites with different ruggedness and vegetation density. Visually, the MVSR filter showed the smoothest and thinnest ground profiles, with ATIN the only filter performing comparably (although the profiles were somewhat thicker and not as complete as MVSR-acquired ground). The same was confirmed when comparing ground filtered by other filters with the MVSR-based surface. The goodness of fit with the original cloud is demonstrated by the root mean square deviations (RMSD) of the points from the original cloud found below the MVSR-generated surface (ranging, depending on site, between 0.6-2.5 cm). ATIN again performed closest to MVSR, with RMSDs of ground filtered points found above MVSR-based surface at individual sites ranging between 4.5-7.4 cm. The remaining filters performed comparable in the simplest flat area but poorly in rugged and much-vegetated sites, with RMSDs above the MVSR surface ranging at such sites from 21 to 95 cm. In conclusion, the novel filter presented in this paper performed outstandingly at all sites, identifying the ground points with great accuracy while filtering out the maximum of vegetation/above-ground points. The filter dilutes the cloud somewhat; in such dense point clouds, however, this can be perceived rather as a benefit than as a disadvantage.

Preprint ARTICLE | doi:10.20944/preprints202207.0049.v1

Reconstructing the Three-Dimensional Structure of Loop Current Rings from Satellite Altimetry and in situ Data using the Gravest Empirical Modes Method

Thomas Meunier, Paula Perez Brunius, Amy Bower

Subject: Environmental And Earth Sciences, Oceanography Keywords: three-dimensional eddy reconstruction; Loop Current rings; Gulf of Mexico; Gravest Empirical Modes

Online: 4 July 2022 (10:05:40 CEST)

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Working Paper ARTICLE

MPPT Circuit Using Time Exponential Rate Perturbation and Observation for Enhanced Tracking Efficiency for a Wide Resistance Range of Thermoelectric Generator

Jie Miao, Houpeng Chen, Yu Lei, Yi Lv, Weili Liu, Zhitang Song

Subject: Engineering, Automotive Engineering Keywords: maximum power point tracking (MPPT); thermoelectric generator (TEG); time exponential rate perturbation and observation (P&O); power modulator

Online: 19 April 2021 (13:26:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0180.v1

MPCR-Net: Multiple Partial Point Clouds Registration Network Using a Global Template

Shijie Su, Chao Wang, Ke Chen, Jian Zhang, Yang Hui

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: point cloud registration; template point cloud; multiple partial point cloud; deep learning

Online: 10 September 2021 (10:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0302.v1

Optimizing Intrusion Detection Systems: Exploring the Impact of Feature Selection, Normalization and Three-Phase Precision on the Cse-Cic-Ids-2018 Dataset

Surasit Songma, Theera Sathuphan, Thanakorn Pamutha

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: intrusion detection system; machine learning techniques; Exploratory Data Analysis; Performance Evaluation; feature selection; CSE-CIC-IDS-2018 dataset; Three phase models

Online: 6 November 2023 (07:46:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0318.v1

An Investigation of Three-finger Toxin – nAChR Interactions through Rosetta Protein Docking

Alican Gulsevin, Jens Meiler

Subject: Biology And Life Sciences, Biophysics Keywords: nicotinic acetylcholine receptors; three-finger toxins; acetylcholine binding protein; protein – protein docking; computational modeling

Online: 14 August 2020 (09:57:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2085.v1

Biosensing for Autoimmune Chronic Disease: A Review

Rebecca Golfinopoulou, Spyridon Kintzios

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: autoantibodies; autoimmune; biomarker; biosensor; chronic disease; cytokines; microRNAs; Point-of-Care

Online: 30 May 2023 (08:25:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1120.v1

Non-Rigid Point Cloud Registration Using Piece-Wise Tricubic Polynomials as Transformation Model

Philipp Glira, Christoph Weidinger, Johannes Otepka-Schremmer, Camillo Ressl, Norbert Pfeifer, Michaela Haberler-Weber

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: pointcloud registration; iterative closest point; transformation; lidar

Online: 18 October 2023 (11:35:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1349.v1

Study on the Movement Characteristics of Fuel in the Fuel Tank during Maneuvering Process

Yameng Wang, Chenran Ruan, Song Lu, Zhenghong Li

Subject: Engineering, Aerospace Engineering Keywords: Aircraft fuel system; Maneuvering; Free surface; Wing fuel tank; Finite point set method

Online: 18 May 2023 (14:17:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0340.v2

Spin g Factors and Neutrino Magnetic Moment of Elementary Fermions

Jae-Kwang Hwang

Subject: Physical Sciences, Particle And Field Physics Keywords: Anomalous spin g factor; Lepton charge (LC); Neutrino magnetic moment; Weak force decay; EC and LC partial masses; Three-dimensional quantized space model (TQSM)

Online: 1 March 2022 (11:25:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0804.v1

PCRMLP : A Two-Stage Network for Point Cloud Registration in Urban Scenes

Jingyang Liu, Yucheng Xu, Lu Zhou, Lei Sun

Subject: Computer Science And Mathematics, Robotics Keywords: registration; point clouds; urban scene; deep learning

Online: 23 April 2023 (13:59:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1431.v1

Surveying and Geographic Information Systems (GIS): Exploring the Capabilities of Unmanned Aerial Vehicles (UAV)/Drones

Ezra Chipatiso

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: photogrammetry; unmanned aerial vehicles (UAV); 3D point cloud; geographic information systems (GIS)

Online: 21 September 2023 (03:39:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0269.v1

Analytical Derivations of Critical Temperatures in Every Type of Fe-Based Superconductors Based on Two Electrons’ Rotational Model

Shinichi Ishiguri

Subject: Physical Sciences, Condensed Matter Physics Keywords: Fe-based superconductor; critical temperature; transition temperature; attractive Lorentz force; Tc-dome diagram; structure transition; quantum critical point

Online: 18 July 2022 (11:03:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0032.v1

Characterization of Cardiopulmonary Interactions and Exploring Their Prognostic Value in Acute Bronchiolitis: A Prospective Cardiopulmonary Ultrasound Study

Moises Rodriguez-Gonzalez, Patricia Rodriguez-Campoy, Lorena Estepa-Pedregosa, Ana Estalella-Mendoza, Ana Castellano-Martinez, Jose Carlos Flores-Gonzalez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Acute bronchiolitis; Lung ultrasound; Echocardiography; Point of care ultrasonography; Cardi-opulmonary ultrasound; Cardiopulmonary interactions; Pulmonary hypertension; Myocardial strain; NT-proBNP

Online: 2 December 2021 (11:22:02 CET)

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We aimed to delineate cardiopulmonary interactions in acute bronchiolitis and to evaluate the capacity of a combined cardiopulmonary ultrasonography to predict the need for respiratory support. This was a prospective observational single-center study that includes infants < 12 month of age admitted to a hospital due to acute bronchiolitis. All the included patients under-went clinical, laboratory and cardiopulmonary ultrasonographic evaluation at the same time point within 24 hours of hospital admission. The existence of significant correlation between car-diac and respiratory parameters was the primary outcome. The association of different cardio-pulmonary variables with the need of respiratory support higher than O2, the length of stay hos-pitalization, the PICU stay, and the duration of respiratory support were a secondary outcome. We enrolled 112 infants (median age 1 (0.5-3) months; 62% males) hospitalized with acute bron-chiolitis. Increased values of the pulmonary variables (BROSJOD score, pCO2 and LUS) showed moderate correlations with NT-proBNP and all echocardiographic parameters indicative of pulmonary hypertension and myocardial dysfunction. Up to 36 (32%) infants required respira-tory support during the hospitalization. This group presented with higher lung ultrasound score (p<0.001), and increased values of Tei index (p<0.001) and pulmonary artery pressures (p<0.001). All the analyzed respiratory and cardiac variables showed moderate to strong correlations with the LOS hospitalization and the time of respiratory support. Lung ultrasound and echocardiog-raphy showed a moderate to strong predictive accuracy for the need of respiratory support in the ROC analysis, with AUC varying from 0.74 to 0.87. Conclusion: Those cases of bronchiolitis with a worse pulmonary status presented with a more impaired cardiac status. Cardiopulmonary ul-trasonography could be a good strategy to easily identify high-risk population for a complicated acute bronchiolitis hospitalization.

Preprint REVIEW | doi:10.20944/preprints202304.0989.v1

An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease

Mara Schvarzstein, Fatema Alam, Muhammad Toure, Judith L Yanowitz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Whole genome duplication; tetraploidy; polyploidy; aneuploidy; Caenorhabditis; WGD model (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)

Online: 26 April 2023 (12:43:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0447.v2

Seismic Signatures and Site Characterization of an Intermittent Stream in Dry and Flood Conditions: An Implication for Soil Losses and Landslide Triggering

Yawar Hussain, Helena Seivane, Gao Qiangshan, Susanne Maciel, Omar Hamza, Rogério Uagoda, Welitom Rodrigues Borges

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: change-point analysis; weak spots; spectral analysis; ambient noise RMS; georadar attribute

Online: 16 November 2022 (02:35:38 CET)

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Identifying ambient noise-based (ANb) signatures of streams can help in the estimation of their erosive potential (EP) that promotes reverie landslides and soil losses in the fluvial valleys. This is particularly imperative on flooding or rainy days, leading to stronger erosion-prone conditions (colluvium and boulders) of the valley beds inferred from georadar attribute analysis. Developing such research direction can benefit the local communities, as is the case with the Cerrado region of Brazil, where these phenomena have high destructive potential with social, economic, and climatic implications. For the present study, a seasonal stream in the Federal District of Brazil was investigated by ANb monitoring supported by Ground Penetration Radar (GPR) for site characterization. The ANb monitoring was conducted (at a safe distance) with a seismometer over several durations of dry and rainy conditions. The power spectral density (PSDs) was computed as a function of several variables, including weather conditions (rainfall, wind speed, and pressure), time-frequency spectrograms, and ambient noise displacement root mean square (RMS). This analysis also considered the single station horizontal-to-vertical spectral ratio (HVSR), where rain, wind, pressure, river flow and anthropogenic signatures were evident (at selective frequency ranges). Multi-peaks that emerged on the HVSR curve were further analyzed to identify amplitude and frequency changes, and the three peaks shift on average to a lower position during the rainy period. The GPR amplitude and waveform variation features were attributed to the stratigraphy (i.e., the boundary between valid and invalid regions and coherence value) of the floodplain and regions susceptible to erosion (erosion-prone lithological spots). This approach provides the basis for non-destructive monitoring tools enabling the detection of 'seismic signatures' and weak spots of the fluvial channels for improving environmental management.

Preprint ARTICLE | doi:10.20944/preprints202304.0370.v1

LBFNet: A Tomato Leaf Disease Identification Model based on Three-Channel Attention Mechanism and Quantitative Pruning

Hailin Chen, Yi Wang, Jialiang Peng, Ruofan Zhang, Pin Jiang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: artificial intelligence; three-channel attention mechanism; Tomato Leaf Disease; convolution neural network; deep learning

Online: 14 April 2023 (10:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0002.v1

Hospitalist Perceptions of Barriers to Lung Ultrasound Adoption in Diverse Hospital Environments

Anna M. Maw, P. Michael Ho, Megan A. Morris, Russell E. Glasgow, Amy G. Huebschmann, Juliana G. Barnard, Robert Metter, David M. Tierney, Benji K. Mathews, Edward P. Havranek, Mark Kissler, Michelle Fleshner, Barbra K. Burian, Elke Platz, Nilam J. Soni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: lung ultrasound; implementation science; point of care ultrasound

Online: 1 July 2021 (07:43:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0320.v2

Evaluation of a Novel Methodology for Real-Time Calculation of Critical Blood Values Based on Four Measured Values

Rüdiger H. Ettrich, Joshua Caballero, Sultan Ahmed, Traci Hurlston, Jayesh Parmar, Subrata Deb

Subject: Medicine And Pharmacology, Hematology Keywords: non-invasive; point-of-care testing; blood values; Radial arterial blood; blood gas; transcutaneous; algorithm

Online: 4 May 2023 (03:07:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0034.v1

SAUSA: Securing Access, Usage, and Storage of 3D Point Clouds Data by a Blockchain-based Authentication Network

Ronghua Xu, Yu Chen, Genshe Chen, Erik Blasch

Subject: Computer Science And Mathematics, Information Systems Keywords: Blockchain; Smart Contract; Point Cloud; Security; Privacy Preservation; Software-Defined Network (SND); Big Data; Assurance; Resilience.

Online: 2 November 2022 (02:18:50 CET)

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The rapid development of three-dimensional (3D) acquisition technology based on 3D sensors provides a large volume of data, which is often represented in the form of point clouds. Point cloud representation can preserve the original geometric information along with associated attributes in a 3D space. Therefore, it has been widely adopted in many scene-understanding-related applications such as virtual reality (VR) and autonomous driving. However, the massive amount of point cloud data aggregated from distributed 3D sensors also poses challenges for secure data collection, management, storage, and sharing. Thanks to the characteristics of decentralization and security nature, Blockchain has a great potential to improve point cloud services and enhance security and privacy preservation. Inspired by the rationales behind Software Defined Network (SDN) technology, this paper envisions SAUSA, a blockchain-based authentication network that is capable of recording, tracking, and auditing the access, usage, and storage of 3D point cloud data sets in their life-cycle in a decentralized manner. SAUSA adopts an SDN-enabled point cloud service architecture which allows for efficient data processing and delivery to satisfy diverse Quality-of-Service (QoS) requirements. A blockchain-based authentication framework is proposed to ensure security and privacy preservation in point cloud data acquisition, storage, and analytics. Leveraging smart contracts for digitizing access control policies and point cloud data on the blockchain, data owners have full control of their 3D sensors and point clouds. In addition, anyone can verify the authenticity and integrity of point clouds in use without relying on a third party. Moreover, SAUSA integrates a decentralized storage platform to store encrypted point clouds while recording references of raw data on the distributed ledger. Such a hybrid on-chain and off-chain storage strategy not only improves robustness and availability but also ensures privacy preservation for sensitive information in point cloud applications. A proof-of-concept prototype is implemented and tested on a physical network. The experimental evaluation validates the feasibility and effectiveness of the proposed SAUSA solution.

Preprint SHORT NOTE | doi:10.20944/preprints202103.0604.v1

N,N-bis(2-quinolinylmethyl)benzylamine

Leigh Andre Hunter, Shivani Naidoo, Allen Mambanda

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: H-bonds (-bonding): hydrogen bonds (-bonding); q: quinoline; 3-/2D: three-/two dimensional & VdW: Van der Waal & bqma: bis(2-quinolinylmethyl)amine

Online: 24 March 2021 (16:40:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1231.v1

Comparative Study of IGBT and SiC MOSFET Three-Phase Inverter: Impact of Parasitic Capacitance on the Output Voltage Distortion

Paisak Poolphaka, EHSAN JAMSHIDPOUR, Thierry Lubin, Lotfi Baghli, Noureddine Takorabet

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC/AC converter; Three-phase inverter; High frequency applications; Performance comparison

Online: 17 August 2023 (09:24:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0196.v1

Design of Electrically Conductive Adhesives and Adhesive Joints

Erol Sancaktar

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Conductive fillers; percolation threshold; two-dimensional conductivity; three-dimensional conductivity; directional conductivity; pressure effect; thickness effect; contact resistance; surface effect; conductivity-mechanical property relation; magnetic particle alignment; geometry effect; conductive nanoparticles; soft ECA's; volume fraction - adhesive thickness relation

Online: 4 July 2023 (10:30:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1821.v1

Point-of-Care Ultrasound (POCUS) Assessment, Including Learning Curve: Developing a Dynamic Simulation Model

Sandra Patricia Usaquén-Perilla, Laura Valentina Bocanegra-Villegas, José Isidro García-Melo

Subject: Engineering, Bioengineering Keywords: System dynamics; Health Technology Assessment (HTA); Point-of-care ultrasound (POCUS); dengue

Online: 26 May 2023 (03:06:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0725.v3

The Effect of Dissociation on the Binocular Visual Response in Children

Danjela Ibrahimi, Marcos Aviles, Juvenal Rodríguez-Reséndiz

Subject: Medicine And Pharmacology, Ophthalmology Keywords: visual function; Howell test; alternate Cover test; Thorington test; dissociated phoria state; break value of near point of convergence; degree of stereopsis

Online: 22 June 2023 (10:43:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0277.v2

Research on Mechanical Braking Model of Cows Knee Joint

Meng Liu, Kexin Meng, Shuli Mei, Ruyi Xing

Subject: Physical Sciences, Mathematical Physics Keywords: Dairy cow; Lyapunov exponent; bio-mechanical model; Nonlinear dynamics; gait; Weight scale; Three-link model; Fractals

Online: 24 February 2022 (09:57:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0358.v1

A Modified single frequency PPP method for the Positioning and Time transfer with BDS-3

Mingjun OuYang, Xiangwei Zhu, Junzhi Li, Liu Yang

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: BDS-3; Time transfer; Precise point positioning; Single frequency; Group and Phase Ionospheric Correction (GRAPHIC)

Online: 24 October 2022 (10:01:41 CEST)

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