Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Implementation of Antimicrobial Stewardship in a District Hospital in the Ashanti Region of Ghana Using a Health Partnership Model

Obed Kwabena Offe Amponsah
* ORCID logo ,
Aaron J. Courtenay
ORCID logo ,
Ahmed Abuelhana
ORCID logo ,
Nana Kwame Ayisi-Boateng
ORCID logo ,
Douglas Anning Opoku
ORCID logo ,
Lawrence Kobbina Blay
,
Nana Akua Abruquah
,
Annabella Bensusan Osafo
,
Charlotte Boachie Danquah
,
Phyllis Tawiah
,
Mercy Naa Aduele Opare-Addo
,
Alex Owusu-Ofori
ORCID logo ,
Kwame Ohene Buabeng
Version 1 : Received: 19 December 2022 / Approved: 23 December 2022 / Online: 23 December 2022 (03:53:09 CET)

A peer-reviewed article of this Preprint also exists.

Amponsah, O.K.O.; Courtenay, A.; Ayisi-Boateng, N.K.; Abuelhana, A.; Opoku, D.A.; Blay, L.K.; Abruquah, N.A.; Osafo, A.B.; Danquah, C.B.; Tawiah, P.; et al. Assessing the Impact of Antimicrobial Stewardship Implementation at a District Hospital in Ghana Using a Health Partnership Model. JAC-Antimicrobial Resistance 2023, 5, doi:10.1093/jacamr/dlad084. Amponsah, O.K.O.; Courtenay, A.; Ayisi-Boateng, N.K.; Abuelhana, A.; Opoku, D.A.; Blay, L.K.; Abruquah, N.A.; Osafo, A.B.; Danquah, C.B.; Tawiah, P.; et al. Assessing the Impact of Antimicrobial Stewardship Implementation at a District Hospital in Ghana Using a Health Partnership Model. JAC-Antimicrobial Resistance 2023, 5, doi:10.1093/jacamr/dlad084.

Abstract

Commonwealth Partnerships for Antimicrobial Stewardship (AMS) uses a health partnership model to establish AMS in Commonwealth countries. The University Hospital of Kwame Nkrumah University of Science and Technology in partnership with Ulster University, in Northern Ireland undertook an AMS project from November 2021 to May 2022. We report on the implementation and its effect on antibiotic use and infections management at the University Hospital. The Global-Point Prevalence Survey (PPS) protocol was used to assess antibiotics use at the hospital at the beginning, midpoint and end of the project. Feedback on each PPS was given to staff to inform behaviour change and improve antibiotic prescribing. Antibiotic use reduced from 65% at baseline to 59.7% at the end of the project. The rate of health-associated infections also reduced from 17.5% at baseline to 6.5%. In addition, the use of antibiotics belonging to the WHO Access group at the hospital was 40% initially but increased to 50% at the project endpoint. Culture and antibiotic susceptibility requests increased from the beginning of the project from 111 total requests to 330 requests over 7 months. The AMS model implemented improved antibiotic use as well as requests for culture and susceptibility test which must be sustained.

Keywords

Antimicrobial stewardship; Point prevalence survey; Antimicrobial resistance; Ghana; CwPAMS; Antibiotic use; THET

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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