Version 1
: Received: 17 February 2023 / Approved: 20 February 2023 / Online: 20 February 2023 (06:07:08 CET)
Version 2
: Received: 2 May 2023 / Approved: 4 May 2023 / Online: 4 May 2023 (03:07:48 CEST)
How to cite:
Ettrich, R.H.; Caballero, J.; Ahmed, S.; Hurlston, T.; Parmar, J.; Deb, S. Evaluation of a Novel Methodology for Real-Time Calculation of Critical Blood Values Based on Four Measured Values. Preprints2023, 2023020320. https://doi.org/10.20944/preprints202302.0320.v2
Ettrich, R.H.; Caballero, J.; Ahmed, S.; Hurlston, T.; Parmar, J.; Deb, S. Evaluation of a Novel Methodology for Real-Time Calculation of Critical Blood Values Based on Four Measured Values. Preprints 2023, 2023020320. https://doi.org/10.20944/preprints202302.0320.v2
Ettrich, R.H.; Caballero, J.; Ahmed, S.; Hurlston, T.; Parmar, J.; Deb, S. Evaluation of a Novel Methodology for Real-Time Calculation of Critical Blood Values Based on Four Measured Values. Preprints2023, 2023020320. https://doi.org/10.20944/preprints202302.0320.v2
APA Style
Ettrich, R.H., Caballero, J., Ahmed, S., Hurlston, T., Parmar, J., & Deb, S. (2023). Evaluation of a Novel Methodology for Real-Time Calculation of Critical Blood Values Based on Four Measured Values. Preprints. https://doi.org/10.20944/preprints202302.0320.v2
Chicago/Turabian Style
Ettrich, R.H., Jayesh Parmar and Subrata Deb. 2023 "Evaluation of a Novel Methodology for Real-Time Calculation of Critical Blood Values Based on Four Measured Values" Preprints. https://doi.org/10.20944/preprints202302.0320.v2
Abstract
The purpose of this work was to evaluate a novel methodology developed by Digital Blood Corporation (DBC) to calculate critical blood values using four non-invasive measured values as input. The values obtained using a point-of-care testing (POCT) device were utilized for comparison and reference. Radial arterial blood was collected for the POCT comparator analysis using the Abbott i-STAT® device. The non-invasive methodology from DBC requires four parameters to be directly measured: temperature, hemoglobin, pO2, and pCO2. Subsequently, sodium, potassium, chloride, ionized calcium, total carbon dioxide, pH, bicarbonate, and oxygen saturation are calculated using an algorithm. The agreement between the POCT and DBC’s methodology was analyzed using Bland-Altman difference plots. For a second data set, pO2 and pCO2 values collected with the POCT were used as input for DBC’s algorithm to test its robustness. Data from 37 healthy ambulatory individuals, mean age: 42.4 + 13 years; range: 18-64 years, were included in the primary analysis. In the case of the non-invasive gained four input values the greatest variation between POCT and DBC’s approach was observed for pO2 and consequently for algorithm values that depend upon pO2 precision. Replacing transcutaneous pO2 and pCO2 with POCT values demonstrates the principal ability of DBC’s algorithm to predict the additional 8 blood values in sufficient agreement with a standard POCT device in healthy patients. The algorithm developed by DBC appears to be robust in the case of healthy patients but does need the four measured input values with preciseness comparable to a POCT device to give reliable and clinically relevant results. The present study thus serves as a proof of concept to facilitate future study and further development of this methodology into a non-invasive device.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Subrata Deb
Commenter's Conflict of Interests: Author