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Preprint CASE REPORT | doi:10.20944/preprints201912.0264.v2

4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy

Csaba Tóth, Andrea Dabóczi, Madhvi Chanrai, Mária Schimmer, Katalin Horváth, Zsófia Clemens

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: glioblastoma; brain tumor; paleolithic diet; ketogenic diet; paleolithic ketogenic diet; metabolic therapy; intestinal permeability; cancer treatment

Online: 9 November 2020 (11:25:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0003.v6

Farey Sequences and the Riemann Hypothesis

Darrell Cox

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann hypothesis, Farey sequence, Gauss sum associated with a Dirichlet character

Online: 10 August 2016 (11:35:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0234.v1

Sequence Properties of the MAAP Protein and of the VP1 Capsid Protein of Adeno-Associated Viruses

David G. Karlin

Subject: Biology And Life Sciences, Virology Keywords: adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix

Online: 17 February 2020 (02:42:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0169.v1

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Liudmyla Lazarenko, O. Melnikova, Lidiia Babenko, Rostyslav Bubnov, Tetiana Beregova, Tetiana Falalyeyeva, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: metabolic syndrome; diabetes mellitus; obesity, lactobacilli; bifidobacteria; glucose; macrophages; inflammation; mouse model

Online: 8 August 2018 (14:27:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0060.v1

Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

Thomas Ziebart, Sebastian Blatt, Junho Jung, Andreas Pabst, Christian Walter, Frank Halling, Paul Heymann, Andreas Neff, Leonardo Righesso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingiva; bisphosphonate; soft tissue; fibroblasts; keratinocytes; bisphosphonate associated osteonecrosis of the jaws

Online: 15 October 2016 (08:03:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0001.v1

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

Shan-Ling Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Chih-Hsiang Hsu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: protein-disulfide isomerase-associated 3; osteoarthritis; extracorporeal shockwave therapy; 1α,25-Dihydroxyvitamin D3 signaling pathway; two dimensional electrophoresis

Online: 1 September 2016 (10:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0425.v1

Obstructive Sleep Apnea as a Cause of Gout

Burton Abrams, Peter Delannoy, Richard Johnson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: sleep apnea; hypoxia; gout; hyperuricemia; urate; metabolic comorbidities

Online: 24 February 2023 (09:31:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0043.v1

Arms Race between Enveloped Viruses and the Host ERAD Machinery

Dylan A. Frabutt, Yong-Hui Zheng

Subject: Biology And Life Sciences, Virology Keywords: enveloped viruses; viral glycoproteins; endoplasmic reticulum-associated degradation; ERAD; unfolded protein response; UPR; ER stress

Online: 4 August 2016 (11:44:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0019.v1

“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling

Marietta Kokla, Anton Klåvus, Stefania Noerman, Ville M. Koistinen, Marjo Tuomainen, Iman Zarei, Topi Meuronen, Merja R. Häkkinen, Soile Rummukainen, Ambrin Farizah Babu, Taisa Sallinen, Olli Kärkkäinen, Jussi Paananen, David Broadhurst, Carl Brunius, Kati Hanhineva

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; LC-MS; mass spectrometry; metabolic profiling; computational; statistical; unsupervised learning; supervised learning; pathway analysis

Online: 3 February 2020 (05:54:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0098.v1

MicroRNAs in the Communication between Cancer Associated Fibroblasts (CAF) and Cancer Cells

Maren Schoepp, Anda Jana Stroese, Joerg Haier

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA; cancer associated fibroblasts; cell-cell communication; transformation; epigenetic

Online: 28 February 2017 (10:29:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0132.v1

Geography of Food Consumption Patterns between South and North China

Fangfang Song, Mi Sook Cho

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chinese adults; north region; south region; dietary pattern; metabolic syndrome

Online: 31 October 2016 (02:51:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0155.v1

Cancer-associated Fibroblasts: Origins, Heterogeneity and Functions in Tumor Microenvironment

Kevin Dzobo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Tumor microenvironment; tumor stroma; cancer-associated fibroblasts; heterogeneity; biomarkers; cancer; The Cancer Genome Atlas; gene expression; computational biology

Online: 15 January 2020 (12:56:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0211.v2

HIV-1: Tackling the Obstacles that Limit the Effectiveness of CRISPR-Cas9 Gene Editing of the T Cell Co-receptor CCR5

Tatiana Hillman

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: HIV-1; CRISPR-Cas9; T-cells; lipid nanoparticles; gut-associated-lymphoid tissue; Co-receptors; Probiotics; GI Tract,; Gene Editing

Online: 13 April 2020 (10:57:52 CEST)

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HIV-1 is a complicated and perplexing virus. It infects T cells, reverse transcribes its RNA into DNA, utilizes its host DNA machinery to replicate its HIV-DNA, translates the HIV-DNA into proteins, assembles itself for a budding escape from the T cell, and rapidly mutates its conformation. Partially, due to its complexity, there remains no cure for HIV or AIDs. However, recently with the discovery of TALENs, the use of zinc fingers, and most of all the applications of CRISPR-Cas9 technology, has given researchers new hope in finding alternative gene therapies and treatments for diseases. With more focus on CRISPR-Cas9, this new and novel technology uses a guiding RNA, sgRNA, to lead a Cas9 nuclease to its target for deletion or to change that DNA site. CRISPR-Cas9 can delete point mutations and multiple DNA sites. Because CRISPR can alter DNA sequences, several scientists have conducted research into CRISPR, possibly treating more diseases such as cancer, diabetes, and even HIV. HIV-1 drew the focus of a researcher named Dr. Ebina in 2013 when he was the first to design and apply CRISPR-Cas9 to genes found in the binding sites of HIV-1, inhibiting HIV-1 gene expression. Since 2013, several other researchers have blocked HIV replication and infection through CRISPR-Cas9 targeting the receptors of T cells called the CC chemokine receptor 5 or CCR5. HIV-1 binds to the CD4 receptor of T cells, which consists of co-receptors CCR5 and CXCR4. If CCR5 expression can be removed, the HIV virus cannot bind to T-cells, blocking the initial attachment stage, and discontinuing the infection. However, there remain obstacles and issues for the CRISPR deletion of CCR5 for treating HIV-1. The issues include: 1) finding new and safe methods of CRISPR-Cas9 delivery, 2) clearing the latent HIV reservoirs, 3) improving the sgRNA design to avoid off-target mutations or deletions, and 4) effectively analyze the viral escape of HIV from CRISPR-Cas9 modifications. Therefore, the purpose of this review is to discuss possible techniques for removing the obstacles that can lessen the potential of CRISPR to delete CCR5, repressing HIV-1 into long-term remission or a functional cure.

Preprint REVIEW | doi:10.20944/preprints201706.0121.v1

Molecular interactions of autophagy with the immune system and cancer

Yonggeun Hong, Yunho Jin, Yunkyung Hong, Chanyoung Park

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: autophagy； immune system； cancer；cell death；metabolic homeostasis

Online: 27 June 2017 (06:30:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0638.v1

Shugoshin: From a Perspective of Clinical Disorders

Ravinder Kumar, Meenakshi Agarwal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Shugoshin; tumor suppressor; cancer; oncogene; tumour associated gene

Online: 25 March 2021 (15:31:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint REVIEW | doi:10.20944/preprints201704.0171.v1

Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic Mice

Sohsuke Yamada, Xin Guo, Akihide Tanimoto

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Peroxiredoxin (PRDX) 4, chronic inflammatory disease, metabolic syndrome, human PRDX4 transgenic mice (Tg), animal model.

Online: 26 April 2017 (17:57:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0124.v1

Assessing and Resolving Model Misspecifications in Metabolic Flux Analysis

Rudiyanto Gunawan, Sandro Hutter

Subject: Engineering, Bioengineering Keywords: metabolic flux analysis, model misspecification, constraint-based model, stoichiometric model, Chinese hamster ovary cell culture

Online: 16 March 2017 (17:38:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0093.v1

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Vibeke Andersen, Axel Kornerup Hansen, Berit Lilienthal Heitmann

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: lifestyle factors; chronic inflammatory diseases; treatment result; treatment response; diet; meat intake; dietary pattern; food; mucosa associated bacteria; epithelium-associated bacteria; microbiome; fibre intake; personalized medicine; mucus; sulphate-reducing bacteria; mucin-degrading bacteria; Western style diet; anti-TNF

Online: 15 March 2017 (07:29:13 CET)

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Preprint REVIEW | doi:10.20944/preprints201803.0064.v2

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

Marit K. Zinöcker, Inge A. Lindseth

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: western diet; microbiome; food processing; inflammation; metabolic diasease

Online: 19 March 2018 (07:31:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201706.0068.v1

Human MAP tau based targeted cytolytic fusion proteins

Olusiji Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human cytolytic fusion proteins; immunotherapy; microtubule associated protein tau (MAP); cancer; inflammatory diseases

Online: 15 June 2017 (12:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0059.v1

Sequestration Effect on the Open-Cyclic Switchable Property of Warfarin by Cyclodextrin: Ultrafast Dynamical Study

Naji Al-Dubaili, Na'il Saleh

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: open-cyclic tautomers; molecular switching; decay-associated spectra; warfarin; excited-state lifetime; cyclodextrins

Online: 21 July 2017 (04:56:54 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201905.0078.v1

Derivations of the Core Functions of the Maximum Entropy Theory of Ecology

Alexander Brummer, Erica Newman

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: information entropy, information theoretics, macroecology, metabolic theory, scaling, species abundance distribution, species-area relationship

Online: 7 May 2019 (11:24:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0185.v1

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Rostyslav Bubnov, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: predictive preventive personalized medicine; Lactobacillus; Bifidobacterium; probiotics, gut microbiota; patient phenotype, individualized medicine; metabolic syndrome

Online: 11 September 2018 (06:00:03 CEST)

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The modification the gut microbiota in metabolic syndrome and associated chronic diseases is among leading tasks of microbiome research and needs for clinical use of probiotics. Evidence lack for the implications for microbiome modification to improve metabolic health in particular when applied impersonalized. Probiotics have tremendous potential in personalized nutrition and medicine to develop healthy diets. The aim was to to conduct comprehensive overview of recent updates of role of microbiota on human health and development of metabolic syndrome and efficacy of microbiota modulation considering specific properties of probiotic strain and particular aspects of metabolic syndrome and patient`s phenotype to fill the gap between probiotic product and individual to facilitate development of individualized / personalized probiotic and prebiotic treatments. We discuss the relevance of using host phenotype-associated biomarkers, those based on imaging and molecular and patrient`s history, reliable and accessible to facilitate person-specific appication of probiotics and prebiotic substances. Microbiome phenotypes can be parameters of predictive medicine to recognize patient`s predispositions and evaluate treatment responses; the number of phenotype markers can be effectively involved to monitor microbiome modulation. The studied strain-dependent properties of probiotic strains are potentially relevant for individualized treatment for gut and distant sites microbiome modulation. The evidence regarding probiotic strains properties can be taken to account via pathophysiology-based approach for most effective individualized treatment via gut, oral and vaginal and other sites microbiome modulation according to phenotype of the patient providing individualized and personalized medical approaches. Preventive potential of probiotics is strong and well-documented. Recommendations for individualized clinical use of probiotics, and for probiotic studies design have been suggested.

Preprint ARTICLE | doi:10.20944/preprints201804.0049.v1

Mangosteen Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study

Mikiko Watanabe, Elena Gangitano, Davide Francomano, Eliana Addessi, Raffaella Toscano, Daniela Costantini, Dario Tuccinardi, Stefania Mariani, Sabrina Basciani, Giovanni Spera, Lucio Gnessi, Carla Lubrano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: garcinia mangostana; inflammation; insulin resistance; metabolic syndrome; diabetes; xanthones; mangostin; phytotherapy; dietary supplements

Online: 4 April 2018 (06:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0078.v1

Factors Influencing the Production of Different Types of Fatty Acid and Staphyloxanthin in the Staphylococcus aureus Membrane

Kiran Tiwari, Craig Gatto, Brian J. Wilkinson

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: membrane fatty acids composition; Staphylococcus aureus; staphyloxanthin; membrane fluidity; metabolic regulation

Online: 6 April 2018 (11:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0210.v1

Intestinal Microbial and Metabolite Profiling of Mice Fed with Dietary Glucose and Fructose

João C. P. Silva, Marta Mota, Fátima O. Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S. Barros, John G. Jones, Ana M. Gil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: fructose; intestinal microbiota; short-chain fatty acids; metabolic profiling

Online: 23 January 2018 (05:31:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201709.0027.v1

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Valeria La Marca, Alessandra Fierabracci

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: EVs; endothelial-derived microparticles; platelet-derived microparticles; non-invasive biomarkers; miRNAs signature; diabetes associated complications; micro-macrovascular damage; diabetic nephropathy

Online: 8 September 2017 (09:38:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0081.v1

Insulin Resistance Syndrome- the Sensitive IRS

Eleni Pellazgu

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: insulin resistance; diet; exercise; microbiome; metabolic disorders

Online: 9 January 2018 (10:05:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0551.v1

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Zahraa Al Wadee, Soo Liang Ooi, Sok Cheon Pak

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Obstructive sleep apnoea; intermittent airway obstruction; sleep disorder; magnesium; micronutrient deficiency; metabolic risk factor

Online: 30 August 2021 (15:47:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0055.v1

The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST)

Lisa Te Morenga, Paul Docherty, Sheila Williams, Jim Mann

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diet; dietary protein; dietary fibre; insulin sensitivity assessment; insulin sensitivity; insulin resistance; metabolic syndrome

Online: 8 November 2017 (16:20:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0064.v1

Metabolic Reprogramming and Its Role in Plant Cold Acclimation

Lisa Fürtauer, Jakob Weiszmann, Wolfram Weckwerth, Thomas Nägele

Subject: Biology And Life Sciences, Plant Sciences Keywords: cold acclimation; metabolic reprogramming; carbohydrates; subcellular metabolism; sucrose cycling; enzyme activity; arrhenius equation; kinetic modelling; arabidopsis thaliana

Online: 7 October 2019 (11:19:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0147.v1

Novel Therapeutic Targets and Biomarkers for the Treatment of Progressive Supranuclear Palsy

Imogen Tyer, Alison Hill

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: PSP; Progressive Supranuclear Palsy; 4R-tau; four-repeat tau; MAPT; Microtubule-associated ligand; PET; Positron Emission Tomography

Online: 12 June 2020 (09:41:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0059.v1

Data Normalization in NMR-based Metabolomics

Helena Zacharias, Michael Altenbuchinger, Wolfram Gronwald

Subject: Biology And Life Sciences, Biophysics Keywords: data normalization; data scaling; zero-sum; metabolic fingerprinting; NMR; statistical data analysis

Online: 3 July 2018 (16:22:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0265.v2

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Melvin Hayden

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Aging; Alzheimer’s disease; brain insulin resistance; db/db diabetic mouse model; diabetic cognopathy; insulin resistance; metabolic syndrome; mixed dementia; obesity; type 2 diabetes mellitus

Online: 9 September 2019 (06:12:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0342.v1

Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis

Ifan Ali Wafa, Nando Reza Pratama, Nurizzah Farahiyah Sofia, Elsha Stephanie Anastasia, Tiffany Konstantin, Maharani Ayuputeri Wijaya, M. Rifqi Wiyono, Lilik Djuari, Hermina Novida

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 lockdown; diabetes mellitus; meta-analysis; metabolic control; systematic review

Online: 14 June 2021 (09:44:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0177.v1

Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice

Gábor Somlyai, Lajos I. Nagy, László G. Puskás, András Papp, Beáta Zs. Kovács, István Fórizs, György Czuppon, Ildikó Somlyai

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet

Online: 13 June 2022 (09:49:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0220.v1

Genetic Optimization Algorithm for Metabolic Engineering Revisited

Tobias B. Alter, Lars M. Blank, Birgitta E. Ebert

Subject: Engineering, Bioengineering Keywords: metabolic strain design; heuristic optimization; constraint-based modeling

Online: 27 March 2018 (05:55:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0331.v1

Coronavirus 2019 Infection in People with Associated Co-Morbidities: Case Fatality and ACE2 Inhibitors Treatment Concerns

Maryam Honardoost, Rokhsareh Aghili, Mohammad E. Khamseh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes

Online: 19 April 2020 (05:42:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0124.v1

Development of a Food-Based Index of Dietary Inflammatory Potential for Koreans and Its Relationship with Metabolic Syndrome

Woori Na, Tae Yang Yu, Cheongmin Sohn

Subject: Biology And Life Sciences, Food Science And Technology Keywords: metabolic syndrome; inflammation; index; Korea

Online: 10 April 2018 (09:50:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0164.v1

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome

Pedram Shokouh, Per Bendix Jeppesen, Kjeld Hermansen, Natalja Nørskov, Christoffer Laustsen, Stephen Jacques Hamilton-Dutoit, Haiyun Qi, Hans Stødkilde-Jørgensen, Søren Gregersen

Subject: Biology And Life Sciences, Food Science And Technology Keywords: coffee; dietary supplements; metabolic syndrome X; non-alcoholic fatty liver disease; adiponectin; hyperpolarized magnetic resonance spectroscopy

Online: 27 October 2017 (02:32:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0063.v1

Probing Molecular Insights of Zika Virus-Host Interactions

Ina Lee, Sandra Bos, Ge Li, Shusheng Wang, Gilles Gadea, Philippe Despres, Richard Y. Zhao

Subject: Biology And Life Sciences, Virology Keywords: Zika virus; ZIKV-host interactions; viral pathogenesis; cell surface receptors; antiviral responses; viral counteraction; cytopathic effects; microcephaly; ZIKV-associated neurologic disorders

Online: 5 April 2018 (05:34:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0272.v1

Metabolic Reprogramming, Meaning and Implications

Pierre Jacquet, Angélique Stéphanou

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Metabolic reprogramming; Warburg effect; Cancer metabolism

Online: 14 January 2021 (13:30:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0163.v1

Yarrowia lipolytica strains and their biotechnological applications: how natural biodiversity and metabolic engineering could contribute to cell factories improvement

Catherine Madzak

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: white biotechnology; metabolic engineering; non-conventional yeast; oleaginous yeast; cell factory; heterologous expression; biodiversity; Yarrowia lipolytica; Yarrowia clade; GMO

Online: 7 June 2021 (10:50:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0036.v1

Molecular Aspects of Varicella-Zoster Virus Latency

Daniel P. Depledge, Tomohiko Sadaoka, Werner J. D. Ouwendijk

Subject: Biology And Life Sciences, Virology Keywords: varicella-zoster virus; latency; reactivation; sensory ganglia; VZV latency-associated transcript; open reading frame 63; RNA-sequencing; epigenetics; immunity

Online: 4 June 2018 (11:49:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0548.v1

Metabolic Modelling Approaches for Describing and Engineering Microbial Communities

Beatriz García-Jiménez, Jesús Torres, Juan Nogales

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: genome-scale metabolic model; microbial community; optimization; design; engineering; computational methods; synthetic microbial consortia

Online: 23 September 2020 (09:52:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0110.v1

An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii

Ashok Aspatwar, Susanna Haapanen, Seppo Parkkila

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: carbonic anhydrases; CA gene family; Chlamydomonas reinhardtii; model alga; metabolic role; photosynthesis

Online: 12 January 2018 (07:21:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0500.v1

Clinical and Structural Biological Studies of Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines

Mei-Yun Cheng, Hsuan-Chen Ho, Jung-Lung Hsu, Yi Wang, Lin-Yi Chen, Ming-Feng Liao, Long-Sun Ro

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Acute disseminated encephalomyelitis; Central nervous system inflammatory demyelinating diseases; COVID-19 vaccines; Myelin oligodendrocyte glycoprotein antibody-associated disease; Neuromyelitis optica spectrum disorders; Transverse myelitis

Online: 8 February 2024 (08:43:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0163.v1

Shaping Light in Backward-Wave Nonlinear Hyperbolic Metamaterials

Alexander K. Popov, Sergey A. Myslivets, Vitaly V. Slabko, Victor A. Tkachenko, Thomas F. George

Subject: Physical Sciences, Optics And Photonics Keywords: optical metamaterials; fundamental concepts in photonics; light-matter interactions at the subwavelength and nanoscale; fundamental understanding of linear and nonlinear optical processes in novel metamaterials underpinning photonic devices and components; advancing the frontier of nanophotonics with the associated nanoscience and nanotechnology; nanostructures that can serve as building blocks for nano-optical systems; use of nanotechnology in photonics; nonlinear nanophotonics, plasmonics and excitonics; subwavelength components and negative index materials; slowing, store, and processing light pulses; materials with such capabilities that could be used for optical sensing, tunable optical delay lines, optical buffers, high extinction optical switches, novel image processing hardware, and highly-efficient wavelength converters

Online: 26 February 2018 (11:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0205.v1

Incorporating an Increase in Plant-Based Food Choices into a model of Culturally Responsive Care for Obesity in Hispanic/Latino Adults and Children

Pramil Singh, Jessica Steinbach, Anna Nelson, Wendy Shih, Mary D'Avila, Selene Castilla, Michael Jordan, William McCarthy, David Hayes Bautista, Hector Flores

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diabetes; vegetarian; diet; nutrition; metabolic syndrome; disparity; child

Online: 17 October 2019 (15:24:37 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202109.0015.v1

HIV Prevalence and Risk Factors for Infants Born to Mothers on Arv Treatment at CHUB/Rwanda

Bernard Nsengimana, Francois Nkurunziza, Wivine Mudahigwa Ntaganira, Ruth Uzayisenga, Gad Rutayisire

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Rwanda; Risk associated MTCT; HIV-exposed infants

Online: 1 September 2021 (12:18:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0029.v2

Incidence and Determinants of Health Care Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study

Mamta Dhaneria, Sachin Jain, Poonam Singh, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: blood stream health care associated infections; neonates; risk factors, antibiotic use, antibiotic resistance; neonatal intensive care unit; India

Online: 30 January 2018 (08:03:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0281.v1

The Role of Apoptotic Signaling in Axon Guidance

Riley Kellermeyer, Leah M. Heydman, Grant S. Mastick, Thomas Kidd

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: axon guidance; growth cone; cytoskeleton; caspases; apoptosis; signal integration; basal level of caspase activity; death associated inhibitor of apoptosis; axon branching; Netrin; DCC; frazzled; slit; robo; Drosophila

Online: 16 September 2018 (09:43:52 CEST)

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Preprint ESSAY | doi:10.20944/preprints202007.0440.v1

Application of Metabolic Engineering Approaches in Enhancing Biological Hydrogen Production

Wenfa Ng

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: metabolic engineering; biohydrogen production; microbes; co-culture; metabolic network analysis

Online: 19 July 2020 (20:43:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0203.v1

Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphoid Cells

Jean-Marie Lambert, Mohamad Omar Ashi, Nivine Srour, Laurent Delpy, Jérôme Saulière

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immunoglobulin (Ig); nonsense-mediated mRNA decay (NMD); nonsense-associated altered splicing (NAS); B lymphocytes; plasma cells

Online: 18 January 2020 (10:21:18 CET)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0271.v1

Blackcurrant Leaf Chlorosis Associated Virus: Next-Generation Sequencing Reveals an Extraordinary Virus with Multiple Genomic Components Including Evidence of Circular RNA

Delano James, James Phelan, Daniel Sanderson

Subject: Biology And Life Sciences, Plant Sciences Keywords: Idaeovirus; Blackcurrant leaf chlorosis associated virus; next-generation sequencing (NGS); bridge reads; abutting primers; RNase R digestion; circular RNA; concatenated RNA

Online: 30 March 2018 (11:40:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0374.v1

Preclinical Evidence of STAT3 Inhibitor, Pacritinib, Overcomes Temozolomide Resistance via Down-Regulating miR-21-enriched Exosomes from M2 Glioblastoma-Associated Macrophages

Hao-Yu Chuang, Yu-kai Su, Heng-Wei Liu, Chao-Hsuan Chen, Shao-Chih Chiu, Der-Yang Cho, Shinn-Zong Lin, Yueh-Sheng Chen, Chien-Min Lin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keywords: Tumor microenvironment (TME), glioblastoma multiforme (GBM), GBM- associated macrophages (GAMs), exosomes, oncomiR-21, STAT3 inhibitor.

Online: 31 May 2019 (08:18:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0244.v1

Curating and Comparing 114 Strain-Specific Genome-Scale Metabolic Models of Staphylococcus aureus

Alina Renz, Andreas Dräger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; MRSA; genome-scale metabolic models; model-driven discovery; strain-specific models

Online: 8 April 2021 (14:25:31 CEST)

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Working Paper ARTICLE

Promoting Exercise in Urban Area: Importance of Green Space and Facility Accessibility

John W.M. Yuen, Katherine K.P. Chang, Frances K.Y. Wong, Fiona Y. Wong, Judy J. Siu, H.C. Ho, M.S. Wong, Janice Y.S. Ho, K.L. Chan, Lin Yang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: physical activity; exercise; green cover; open space; Metabolic Equivalent of Task; International Physical Activity Questionnaire; health promotion

Online: 20 March 2019 (10:46:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0280.v1

A Mechanistic Model for Genome-Scale Estimations of Metabolic Activity

Cankut Cubuk, Carlos Loucera, Marta Hidalgo, Alicia Amadoz, Jose Carbonell-Caballero, María Peña-Chilet, Joaquin Dopazo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: metabolic pathways; mechanistic model; Transcriptomic

Online: 14 January 2021 (18:01:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0248.v1

Joint Transcriptome and Metabolome Analysis Prevails Biological Mechanisms Underlying the Prosurvival Fight in Heat Stressed Granulosa Cells

Abdul Sammad Sammad, Hanpeng Luo, Lirong Hu, Adnan Khan, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; integrated analysis; transcriptomics; metabolomics; differentially ex-pressed genes; metabolites; signaling pathways; metabolic pathways; cancer pathways

Online: 27 April 2022 (05:08:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0139.v1

A High-throughput Method for Fingerprinting of Rhizobial Free Fatty Acids by the Combination of a Thin Film Chemical Deposition Technique and Matrix-assisted Laser Desorption/ionization Time-of Flight Mass Spectrometry

Alexsey Gladchuk, Julia Schumilina, Alena Kusnetsova, Ksenia Bureiko, Alexander Tsarev, Irina Alexandrova, Larisa Leonova, Vladimir A. Zhukov, Igor A. Tikhonovich, Claudia Birkemeyer, Ekaterina Podolskaya, Andrej Frolov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bacteria; barium monocarboxylates; chemical deposition techniques; free fatty acids (FFAs); Langmuir film technology; matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS); metabolic fingerprinting; rhizobia

Online: 13 January 2020 (13:25:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0315.v1

Prevalence of Metabolic Syndrome and Its Associated Factors among Vegetarians in Malaysia

Yuan Kei Ching, Yit Siew Chin, Mahenderan Appukutty, Wan Ying Gan, Vasudevan Ramanchadran, Yoke Mun Chan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: metabolic syndrome; vegetarian; vegetarianism practices; overweight; lifestyle behaviors

Online: 20 June 2018 (08:49:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201904.0209.v1

The Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It

Donatella Aldinucci, Cinzia Borghese, Naike Casagrande

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hodgkin lymphoma; tumor microenvironment; immune escape; tumor-associated macrophages

Online: 18 April 2019 (08:14:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0014.v1

Microbial Degradation of Pharmaceuticals

Swathi Kandhasamy, Sudha Balraj, Suganya Kanagaraj, Sumathi Sundaravadivelu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pharmaceutical toxicants; recalcitrant pollutants; co-metabolic pathways; biostimulation; bioaug-mentation

Online: 1 June 2022 (10:29:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0186.v1

Roles of Extracellular Vesicles (EVs) Carrying HSPs in Cancer Biomarkers, Immune Surveillance, and Immune Evasion

Eman Taha, Kisho Ono, Takanori Eguchi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy

Online: 17 August 2019 (16:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0290.v3

New Workflow Predicts Drug Targets Against SARS-CoV-2 via Metabolic Changes in Infected Cells

Nantia Leonidou, Alina Renz, Reihaneh Mostolizadeh, Andreas Dräger

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: host-virus interactions; tissue-specific model; COVID-19; SARS-CoV-2; antiviral targets; flux balance analysis; flux variability analysis; reaction knockout; host-derived enforcement; metabolic modeling; virus mutations; software engineering; Python

Online: 17 January 2023 (01:50:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0087.v1

Nutritional Quality during Development Alters Insulin-Like Peptides Expression and Physiology of the Adult Yellow Fever Mosquito, Aedes aegypti

Rana Pooriirouby, Arvind Sharma, Joshua Beard, Jeremiah Reyes, Andrew Nuss, Monika Gulia-Nuss

Subject: Biology And Life Sciences, Insect Science Keywords: insulin-signaling; insulin receptor; Aedes aegypti; mosquitoes; insulin; insulin-like peptides; nutrition; hyperinsulinemia; larval-diet; metabolic reserves

Online: 6 June 2018 (11:55:53 CEST)

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Working Paper ARTICLE

Obesity and Telomere Length: Does the Obesity Paradox Exist?

Jin-Hee Kim, Hae-Jin Ko, A-Sol Kim, Ha-Na Moon, Hye-In Choi, Ji-Yeon Park, Sung-Kook Lee, Hee-Jung Yoon

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Body mass index, Metabolic syndrome, Obesity, Obesity paradox, Telomere, Waist circumference, Waist-to-hip ratio, Waist-to-height ratio

Online: 4 September 2019 (14:20:32 CEST)

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Background Telomere shortening is related to aging and unfavourable health outcomes. Obesity and metabolic diseases are important factors for accelerating aging. This study aimed to find out the association between obesity, metabolic disease, and telomere length in metabolically healthy adults. Methods 237 adults were enrolled with written consents at a health promotion centre of a tertiary hospital from February 2014 to March 2015. After excluding 99 subjects who met the exclusion criterion, a total of 130 metabolically healthy subjects were selected for final analysis. The subjects were divided into quartile groups according to the telomere lengths of their oral mucosal cells. Results The subjects consisted of 66 (50.8%) males with a mean age of 58.59 years. The body mass index (BMI, kg/m2) increased significantly along with the quartile groups (Q1, 23.00; Q2, 23.96; Q3, 23.70; Q4, 25.20; P-for trend=0.008). Waist circumference (WC, P-for trend=0.022), waist-to-hip ratio (WHR, P-for trend=0.005), and waist-to-height ratio (WHtR, P=0.001) also increased along with the quartile groups. Obesity prevalence (BMI ≥25 kg/m2), abdominal obesity (WC ≥90 cm for men, ≥85 cm for women), WHR 〉1.0 for men or 〉0.85 for women, and WHtR ≥0.5 increased significantly as the telomere length increased (P-for trend <0.05). After adjusting for covariates, the ORs for each obesity markers increased as the telomere length increased (P-for trend <0.05); and the ORs of WHtR were especially meaningful (Q1, 1.00; Q2, 2.53; Q3, 2.97; Q4, 7.81; P-for trend = 0.001). There were no significant trends for metabolic syndrome and its components along with the prevalence of fatty liver disease. Conclusion Obesity markers and telomere length had significant positive correlation despite the established theory. The obesity paradox may exist in metabolically healthy adults with regard to telomere length, However, further studies with larger sample sizes for the association between obesity and telomere length are needed.

Preprint ARTICLE | doi:10.20944/preprints201906.0086.v1

Hyperglycemia: The Metabolic Syndrome Component That Aggravates Erectile Dysfunction in Mexican Patients

Alan Espinosa-Marrón, Christian A. Quiñones-Capistrán, Aquiles Rubio-Blancas, María del Pilar Milke-García, Ricardo A. Castillejos-Molina

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: erectile dysfunction; metabolic syndrome; risk factors; hyperglycaemia

Online: 11 June 2019 (08:04:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0464.v1

Macrophage-Derived Small Exosomes: Efficient Transmission and Cytotoxicity to Cancer Cells

Yanyin Lu, Takanori Eguchi, Chiharu Sogawa, Eman A. Taha, Manh Tien Tran, Toshiki Nara, Penggong Wei, Shiro Fukuoka, Takuya Miyawaki, Kuniaki Okamoto

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: tumor-associated macrophage; exosomes; extracellular vesicles; heat shock proteins; oral cancer; fluorescent labeling of exosomes

Online: 19 April 2021 (11:50:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0264.v1

Endoplasmic Reticulum Stress in Metabolic Disorders

Rose Ghemrawi, Shyue-Fang Battaglia-Hsu, Carole Arnold

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: endoplasmic reticulum stress; metabolic disorders; unfolded protein response; inflammation; lipotoxicity; glucotoxicity; therapy

Online: 21 May 2018 (08:09:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0209.v1

Utilizing the Food-Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach

Snehal R. Jadhav, Rohan M. Shah, Avinash V. Karpe, Robert Barlow, Kate McMillan, Michelle L. Colgrave, David J. Beale

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: leafy greens; spinach; metabolomics; metabolic profiling; food pathogens; biomarker discovery

Online: 12 January 2021 (08:20:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0928.v1

Neutrophils in Cancer and Potential Therapeutic Strategies using Neutrophil-derived Exosomes

Abhishek Dutta, Shrikrishna Bhagat, Swastika Paul, Jonathan P Katz, Debomita Sengupta, Dharmendra Bhargava

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Neutrophils; Tumor associated neutrophils; neutrophil derived exosomes; immune suppression; metastasis; tumor microenvironment; Neutrophil extracellular trap; Trogocytosis; ADCC and ADCP

Online: 25 April 2023 (13:36:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0027.v1

Determination of Phenolic Composition and Antioxidant Activity in Flowers and Stems of Rumex Tunetanus Using RP-UHPLC-ESI-QTOF-MS

Jouda Abidi, Sonda Ammar, Mohamed Bouaziz

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Rumex tunetanus; Phenolic compounds; Metabolic profiling; Antioxidant activity; RP-UHPLC-ESI-QTOF-MS

Online: 3 December 2018 (13:58:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0040.v1

Advanced Microsamples: Current Applications and Considerations for Mass Spectrometry-Based Metabolic Phenotyping Pipelines

Jayden Lee Roberts, Luke Whiley, Nicola Gray, Melvin Gay, Nathan G. Lawler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Microsampling; sample miniaturisation; dried blood spot (DBS); dried plasma spot (DPS); dried serum spot (DSS); metabolic phenotyping; gas chromatography-mass spectrometry (GC-MS); liquid chromatog-raphy-mass spectrometry (LC-MS)

Online: 3 June 2022 (09:53:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0009.v1

How Smell Regulates Metabolism: The Role Of Ectopically Expressed Olfactory Receptors In Lipid and Glucose Homeostasis

Ginevra Urbani, Eleonora Distrutti, Michele Biagioli, Silvia Marchianò, Stefano Fiorucci

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: olfactory receptors; glucose metabolism; type 2 diabetes mellitus; lipid metabolism; NAFLD; metabolic syndrome

Online: 2 April 2022 (09:00:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0327.v1

Imaging Cancer-Associated Fibroblasts (CAFs) with FAPi PET

Laura Gilardi, Lighea Simona Airò Farulla, Emre Demirci, Ilaria Clerici, Emanuela Omodeo Salé, Francesco Ceci

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer-associated-fibroblast; fibroblast activation protein; FAPi; Positron emission tomography; FAPi PET; theranostics

Online: 21 January 2022 (13:31:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0484.v1

Metformin Sensitizes Leukemic Cells to Cytotoxic Lymphocytes by Increasing Expression of Intercellular Adhesion Molecule-1 (ICAM-1)

Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd-Herbe-de-Maudave, lois coenon, delphine gitenay, Giulia Mitola, paul massa, stefania orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: metformin; Natural Killer cells; Cytotoxic T lymphocytes; intercellular adhesion molecule-1 (ICAM-1); Natural Killer G2-D (NKG2D) ligands (NKG2DL); lymphocyte function-associated antigen 1 (LFA-1)

Online: 21 July 2021 (10:54:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0788.v1

Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

Alina Renz, Lina Widerspick, Andreas Dräger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; Flux Balance Analysis (FBA); Genome-Scale Metabolic Models; Target Identification; Reaction Knock-Out; Structural Proteins; Purine Metabolism; Pyrimidine Metabolism; B.1.1.7; B.1.351

Online: 30 April 2021 (15:14:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0201.v1

An ultradian feeding schedule in rats affects metabolic gene expression in liver, brown adipose tissue and skeletal muscle with only mild effects on circadian clocks

Paul de Goede, Satish Sen, Yan Su, Ewout Foppen, Vincet-Joseph Poirel, Etienne Challet, Andries Kalsbeek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Suprachiasmatic nucleus (SCN); Circadian clock; Soleus Muscle (SM); Brown adipose tissue (BAT); liver; 6-meal feeding; Respiratory exchange ratio (RER); Clock genes; metabolic genes; Shift work.

Online: 11 September 2018 (14:21:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0613.v1

Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Ying Che Huang, Bo-Hua Wu, Yung-Lin Chu, Wen-Chang Chang, Ming-Chang Wu

Subject: Biology And Life Sciences, Food Science And Technology Keywords: tempeh; lactic acid bacteria; short chain fatty acids; metabolic syndrome; high fat diet; feces

Online: 31 July 2018 (09:37:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0629.v1

Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma

Nicholas H. Chakiryan, Gregory J. Kimmel, Youngchul Kim, Joseph O. Johnson, Noel Clark, Ali Hajiran, Andrew Chang, Ahmet M. Aydin, Logan Zemp, Esther Katende, Jad Chahoud, Meghan C. Ferrall-Fairbanks, Philippe E. Spiess, Natasha Francis, Michelle Fournier, Jasreman Dhillon, Jong Park, Liang Wang, James J. Mule, Philipp M. Altrock, Brandon J. Manley

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: metastatic clear cell renal cell carcinoma; cancer associated fibroblasts; Ki-67; spatial analysis; immunohistochemistry

Online: 26 May 2021 (10:53:24 CEST)

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Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a pro-tumor effect in vitro and have been implicated in tumor cell proliferation, metastasis, and treatment resistance. Our objective is to analyze the geospatial distribution of CAFs with proliferating and apoptotic tumor cells in the ccRCC tumor microenvironment and determine associations with survival and systemic treatment. Pre-treatment primary tumor samples were collected from 96 patients with metastatic ccRCC. Three adjacent slices were obtained from 2 tumor-core regions of interest (ROI) per patient, and immunohistochemistry (IHC) staining was performed for αSMA, Ki-67, and caspase-3 to detect CAFs, proliferating cells, and apoptotic cells, respectively. H-scores and cellular density were generated for each marker. ROIs were aligned, and spatial point-patterns were generated, which were then used to perform spatial analyses using a normalized Ripley's K function at a radius of 25μm (nK(25)). The survival analyses used an optimal cut-point method, maximizing the log-rank statistic, to stratify the IHC-derived metrics into high and low groups, and multivariable Cox regression analyses were performed accounting for age and International Metastatic RCC Database Consortium (IMDC) risk category. Survival outcomes included overall survival (OS) from the date of diagnosis, OS from the date of immunotherapy initiation (OS-IT), and OS from the date of targeted therapy initiation (OS-TT). Therapy resistance was defined as progression-free survival (PFS) <6 months, and therapy response was defined as PFS >9 months. CAFs exhibited higher cellular clustering with Ki-67+ cells than with caspase-3+ cells (nK(25): Ki-67 1.19; caspase-3 1.05; P = .04). The median nearest neighbor (NN) distance from CAFs to Ki-67+ cells was shorter compared to caspase-3+ cells (15 μm vs 37μm, respectively; P < .001). Multivariable Cox regression analyses demonstrated that both high Ki-67+ density and H-score were associated with worse OS, OS-IT, and OS-TT. Regarding CAFs, only a high H-score was associated with worse OS, OS-IT, and OS-TT. For caspase-3+, high H-score and density were associated with worse OS and OS-TT. Patients whose tumors were resistant to targeted therapy (TT) had higher Ki-67 density and H-scores than those who had TT response. Overall, this ex vivo geospatial analysis of CAF distribution suggests that close proximity clustering of tumor cells and CAFs potentiates tumor cell proliferation, resulting in worse OS and resistance to TT in metastatic ccRCC.

Preprint REVIEW | doi:10.20944/preprints202011.0069.v1

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms using Computational Systems Biology Approaches

Sahar Aghakhani, Naouel Zerrouk, Anna Niarakis

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Fibroblasts; Rheumatoid Arthritis; Cancer; Metabolic Reprogramming; Glycolytic Switch; Systems Biology; Computational Modelling

Online: 2 November 2020 (19:28:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202204.0202.v1

SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome

Clayton Goddard, Karin Allenspach, Audrey Deflandre, Claudine Zemirline, Emilie Guillot, Jonathan P. Mochel

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Metabolic syndrome; SGLT2 inhibitors; Dapagliflozin; Empagliflozin; Canagliflozin; Translational modeling

Online: 21 April 2022 (10:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0329.v1

Transpiration Responses of Herbicide-Resistant and -Susceptible Palmer amaranth [Amaranthus palmeri (S.) Wats.] to Progressively Drying Soil

Koffi Badou-Jeremie Kouame, Mary C. Savin, Gulab Rangani, Thomas R. Butts, Matthew B. Bertucci, Nilda Roma-Burgos

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: metabolic resistance; drought tolerance; threshold FTSW; stomatal closure; EPSPS gene amplification; S-metolachlor resistance; glyphosate resistance

Online: 21 January 2022 (13:37:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0320.v2

Phylogenetic and Expression Analysis of CENH3 and APOLLO Genes in Sexual and Apomictic Boechera Species

Evgeny Bakin, Fatih Sezer, Aslıhan Özbilen, Irem Kilic, Buket Uner, Mike Rayko, Kemal Melih Taskin, Vladimir Brukhin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Boechera; Brassicaceae; CENH3; APOLLO; apomixis associated genes; cell division; apomeiosis

Online: 20 December 2021 (10:40:57 CET)

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Apomictic plants (reproducing via asexual seeds), unlike sexual individuals, avoid meiosis and egg cell fertilization. Consequently, apomixis is very important for fixing maternal genotypes in the next plant generations. Despite the progress in the study of apomixis, molecular and genetic regulation of the latter remains poorly understood. So far APOLLO (Aspartate Glutamate Aspartate Aspartate histidine exonuclease) is one of the very few described genes associated with apomixis in Boechera species. The centromere-specific histone H3 variant encoded by CENH3 gene is essential for cell division. Mutations in CENH3 disrupt chromosome segregation during mitosis and meiosis since the attachment of spindle microtubules to a mutated form of the CENH3 histone fails. This paper presents in silico characteristic of APOLLO and CENH3 genes, which may affect apomixis. Also, we characterize the structure of CENH3, study expression levels of APOLLO and CENH3 in gynoecium/siliques of the natural diploid apomictic and sexual Boechera species at the stages of before and after fertilization. While CENH3 was a single copy gene in all Boechera species, the APOLLO gene have several polymorphic alleles associated with sexual and apomictic reproduction in the Boechera genera. Expression of the APOLLO apo-allele during meiosis was upregulated in gynoecium of apomict B. divaricarpa downregulating after meiosis until 4th day after pollination (DAP). On the 5th DAP, expression in apomictic siliques increased again. In sexual B. stricta gynoecium and siliques APOLLO apo-allele did not express. Expression of the APOLLO sex-allele during and after meiosis in gynoecium of sexual plants was several times higher than that in apomictic gynoecium. However, after pollination the sex-allele was downregulated in sexual siliques to the level of apomicts and increased sharply on the 5th DAP, while in apomictic siliques it almost did not express. At the meiotic stage, the expression level of CENH3 in the gynoecium of apomicts was two times lower than that of the sexual Boechera, decreasing in both species after meiosis and keep remaining very low in siliques of both species for several days after artificial pollination until the 4th DAP, when the expression level raised in sexual B. stricta siliques exceeding 5 times the level in apomictic B. divaricarpa siliques. We also discuss polymorphism and phylogeny of the APOLLO and CENH3 genes.

Preprint ARTICLE | doi:10.20944/preprints202108.0304.v1

Predictors of Spontaneous Remodelling of Angular Knee Deformities in Children with Healed Nutritional Rickets: A Prospective Cohort Study Protocol

Mostafa M. Baraka, Shady Samir, Shady Mahmoud, Heba Elsedfy, Rana A. Mahmoud, Tamer A. El-Sobky

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Child nutrition disorders; Vitamin D deficiency rickets; Metabolic bone diseases; Genu valgum; Genu varum; Bone remodelling.

Online: 13 August 2021 (22:44:42 CEST)

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Background: Nutritional rickets is still considered as a global health problem especially in low-resource countries and immigrant societies of developed countries. Generalized skeletal deformities including angular knee deformities as genu varum and genu valgum are prominent features of nutritional rickets. Angular knee deformities can cause gait difficulties. However, the true remodelling potential of the healed knee deformities is largely unknown to the pediatric and orthopedic community. Aims: The primary objective of this study protocol is to investigate the natural history of disease in regard to the remodelling potential of angular knee deformities in children and adolescents with healed nutritional rickets. And determine the potential patient- and deformity-related factors that are associated with a favorable deformity remodelling as age and sex of patients and type, severity, laterality of deformities etc. Methods: This will be a prospective observational analytical cohort natural history of disease study. A minimum of at least 140 knees with healed nutritional rickets and angular knee deformities will be observed at regular three-monthly intervals over a period of at least one year. We will report two outcome variables namely; clinical and radiological tibio-femoral angle. And independent patient and deformity-related variables as age, sex, deformity type, severity and laterality. Inferential statistics namely bivariate and multivariate analysis will be employed accordingly to identify the relation between outcome variables and the different independent variables. Ethics and dissemination: This protocol study has been approved by the institutional research ethics committee. Results will be presented at conferences and submitted to relevant international and society publications. Authors will also communicate the results to their scholarly networks and post them on scholarly networking sites. Conclusions: This study has the potential for improving the decision-making process as to which patients deserve conservative treatment and which deserve surgical deformity correction. Results are expected to have an impact on the clinical practice of pediatricians, orthopedic surgeons and family physicians alike.

Preprint REVIEW | doi:10.20944/preprints202311.0461.v1

Ten Quick Tips for Accurate Reconstruction of Prokaryotic and Eukaryotic Genome-Scale Metabolic Models

Gabriela Canto-Encalada, Jenna Armstrong, Carlos Focil-Espinosa4, Ademikanra Adekunle-Fiyin, Ila Peeler, William R. Gebbie, Julio Nunez-Garcia, Alexis Saldivar, Diego Martinez, Cristal Zuniga

Subject: Biology And Life Sciences, Other Keywords: Genome-scale metabolic model reconstruction; manual curation; quick tips; systems biology

Online: 7 November 2023 (14:59:34 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0143.v1

Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity

Babiker M. El-Haj, Samrein B.M. Ahmed, Mousa A. Qarawi, Heyam S. Ali

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Aromatic hydroxy metabolites; arenolic drug metabolites; metabolic O-dealkylation; metabolic aromatic ring hydroxylation; primary and auxiliary pharmacophores; auxophores; metabolic modification of drug activity

Online: 9 July 2018 (13:28:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0517.v1

Metabolite Transporter and Its Impact on Metabolic Engineering Approaches

Mostafa Gomaa FADL

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gram-negative bacterial; Metabolite transporter; pathways; metabolic engineering approaches

Online: 25 January 2021 (15:49:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0123.v1

Effects of Caffeinated and Decaffeinated Coffee Consumption on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials

Nur Nadiah Syuhada Ramli, Areej A Alkhaldy, Abbe Maleyki Mhd Jalil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolic syndrome; caffeinated coffee; decaffeinated coffee; green coffee extract; chlorogenic acid

Online: 4 August 2021 (22:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0280.v1

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase

Colbie Reed, Geoffrey Hutinet, Valérie de Crécy-Lagard

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: comparative genomics; metabolic reconstruction; bioinformatics; conserved unknowns; function prediction; functional annotation; orthology

Online: 13 July 2021 (08:58:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0543.v1

The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity – PRO-DEMET Randomised Study Protocol

Oliwia Gawlik-Kotelnicka, Anna Skowrońska, Aleksandra Margulska, Karolina H. Czarnecka-Chrebelska, Igor Łoniewski, Karolina Skonieczna-Żydecka, Dominik Strzelecki

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; metabolic syndrome; probiotics; microbiota; inflammation; oxidative stress

Online: 24 February 2021 (11:20:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0470.v1

Mouse Ataxin-2 Expansion Downregulates CamKII and other Calcium Signaling Factors, Impairing Granule – Purkinje Neuron Synaptic Strength

Aleksandar Arsović, Melanie Vanessa Halbach, Julia Canet-Pons, Dilhan Esen-Sehir, Claudia Döring, Florian Freudenberg, Nicoletta Czechowska, Kay Seidel, Stephan L. Baader, Suzana Gispert, Nesli-Ece Sen, Georg Auburger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amyotrophic Lateral Sclerosis (ALS); Fronto-Temporal-Lobar-Dementia; Tauopathies; synaptic plasticity; long-term potentiation; spatial learning; inositol signaling; neurexin; K-homology RNA-binding domain; Fragile-X-associated Tremor-Ataxia syndrome

Online: 21 August 2020 (04:39:19 CEST)

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