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Preprint ARTICLE | doi:10.20944/preprints202304.0577.v1

The Generation Time and Accumulations of Lower Paleozoic Petroleum in Sichuan and Tarim Basin Determined by Re–Os Isotopic Dating

Jie Wang, Liangbang Ma, Cheng Tao, Wenhui Liu, Qingwei Dong

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Re–Os isotopic chronology; Pre–treatment means; Petroleum generation time; Lower Paleozoic petroleum; western part of China

Online: 19 April 2023 (08:51:30 CEST)

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With the targets of petroleum exploration transferred to the deep and ancient strata, abundant oil and gas resources have been found in the Lower Paleozoic and older strata in central and western China. Due to complex evolutionary processes including multiple episodes of hydrocarbon accumulation and ubiquitously accompanied by secondary alterations, significant uncertainties were remained for the generation time and accumulation processes of these revealed petroleum. In this paper, relative pure Re and Os elements existing in the asphaltene fractions of Lower Cambrian solid bitumen collected from the Guangyuan area, western Sichuan Basin, SW China and another Middle–Lower Ordovician heavy oils in the Aiding area of the Tahe oilfield in the Tarim Basin, NW China were successfully obtained by the sample pre-treatments, and Re–Os isotopic analysis was subsequently carried out for the dating of these two petroleum. The Re–Os isotopic composition indicates a generation time of Guangyuan bitumen to locate between 572 Ma and 559 Ma, corresponding to the late Sinian period of Neoproterozoic era. By the means of Re–Os isochron ages, initial 187Os/188Os ratios, and carbon isotopic compositions, the Lower Cambrian bitumen is supposed to be originated from source rocks of the Doushantuo Formation in the Sinian strata and subsequently migrated into the reservoirs of Dengying Formation. These previously reserved petroleum had been transformed to present bitumen by the destruction of reservoirs caused by tectonic uplift. The Re–Os dating results of Middle–Lower Ordovician heavy oil of Tarim Basin supposed that it was formed between 450 Ma to 436 Ma, corresponding to the Late Ordovician–Early Silurian system, and the generated petroleum is likely to migrate into the Middle–Lower Ordovician karst reservoirs to form early oil reservoirs. With tectonic uplift, these oil reservoirs were degraded and reformed to be present heavy oil reservoirs.

Preprint ARTICLE | doi:10.20944/preprints202311.1789.v1

Development of an Automatic Paddle Wheel Aerator and Re-mote Movement Water Quality Monitoring for Use in a Marine Shrimp Farm

Natee Thong-un, Piyathat Panthong, Hideharu Takahashi, Hiroshige Kikura, Wongsakorn Wongsaroj

Subject: Engineering, Control And Systems Engineering Keywords: internet of things (IoT); paddle wheel aerator; shrimp; water quality measurement; wireless sensor

Online: 28 November 2023 (08:27:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1602.v1

High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-evaluate the Pathways of Ketamine Metabolism

Nadezhda Y Davydova, David A. Hutner, Kari A. Gaither, Dilip Kumar Singh, Bhagwat Prasad, Dmitri R. Davydov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cytochrome P450; formaldehyde; demethylation; high-throughput assay; human liver microsomes; ketamine; CYP2C19; CYP3A; CYP2D6; CYP2B6

Online: 22 June 2023 (11:26:43 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202305.2186.v1

Is Histamine, and Not Acetyl-choline, the Missing Link between ADHD and Allergy? The Speer Allergic Tension Fatigue Syndrome Re-visited

Hilario Blasco-Fontecilla

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Diamine oxidase deficiency; attention deficit hyperactivity disorder; histamine; cognition; attention

Online: 31 May 2023 (07:42:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0126.v1

Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in 2018 in Touba City, Senegal

Idrissa Dieng, Cheikh Fall, Aboubacry Gaye, Mamadou Aliou Barry, Oumar Faye, Marie Henriette Ndione, Mamadou Diop, Ousmane Faye, Cheikh Loucoubar, Amadou Sall

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Dengue; Touba; Mass gathering; Field Investigation; Mobile laboratory; Phylogeny; Phylogeography

Online: 10 October 2022 (11:21:49 CEST)

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Working Paper ARTICLE

Rethinking the Foundation of Physics and its Relation to Quantum Gravity and Quantum Probabilities: Unification of Gravity and Quantum Mechanics

Espen Haug

Subject: Physical Sciences, Acoustics Keywords: quantum mechanics; quantum probability; de Broglie wavelength; Compton wavelength; gravity; quantum gravity

Online: 24 December 2020 (11:45:05 CET)

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In this paper we will show that standard physics to a large degree consists of derivatives of a deeper reality. This means standard physics is both overly complex and also incomplete. Modern physics has typically started from working with first understanding the surface of the world, that is typically the macroscopic world, and then forming theories about the atomic and subatomic world. And we did not have much of a choice, as the subatomic world is very hard to observe directly, if not impossible to observe directly at the deepest level. Despite the enormous success of modern physics, it is therefore no big surprise that we at some point have possibly taken a step in the wrong direction. We will claim that one such step came when one thought that the de Broglie wavelength represented a real matter wavelength. We will claim that the Compton wavelength is the real matter wavelength. Based on such a view we will see that many equations in modern physics are only derivatives of much simpler relations. Second, we will claim that in today’s physics one uses two different mass definitions, one mass definition that is complete or at least more complete, embedded in gravity equations without being aware of it, as it is concealed in GM, and the standard, but incomplete, kg mass definition in non-gravitational physics. First, when this is understood, and one uses the more complete mass definition that is embedded in gravity physics, not only in gravity physics, but in all of physics, then one has a chance to unify gravity and quantum mechanics. Our new theory shows that most physical phenomena when observed over a very short timescale are probabilistic for masses smaller than a Planck mass and dominated by determinism at or above Planck mass size. Our findings have many implications. For example, we show that the Heisenberg uncertainty principle is rooted in a foundation not valid for rest-mass particles, so the Heisenberg uncertainty principle can say nothing about rest-masses. When re-formulated based on a foundation compatible with a new momentum that is also compatible with rest-masses, we obtain a re-defined Heisenberg principle that seems to become a certainty principle in the special case of a Planck mass particle. Furthermore, we show that the Planck mass particle is linked to gravity and that we can easily detect the Planck scale from gravity observations. The Planck mass particle is unique as it only lasts the Planck time, and in that very short time period it can only be observed directly from itself, and it therefore closely linked to absolute rest.

Preprint ARTICLE | doi:10.20944/preprints201704.0002.v1

The Re-Conceptualization of the Port Supply Chain as a Smart Port Service System: The Case of the Port of Salerno

Antonio Botti, Antonella Monda, Marco Pellicano, Carlo Torre

Subject: Business, Economics And Management, Business And Management Keywords: Smart service systems, Service systems, Service Science, Port Supply Chain Management

Online: 3 April 2017 (16:17:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1276.v1

Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with ARDS Related to SARS-CoV-2 Infection

Pasquale Baratta, Francesco De Sensi, Alberto Cresti, Bruno Sposato, Federica Re, Genni Spargi, Ugo Limbruno

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Inhaled nitric oxide; ARDS; Sars CoV-2; Vasoreactivity Test

Online: 21 March 2024 (12:01:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0582.v1

Seroconversion and Kinetics of Vibriocidal Antibodies during the First 90 Days of Re-vaccination with Oral Cholera Vaccine in an Endemic Population

Caroline Cleopatra Chisenga, Bernard Phiri, Harriet Ngombe, Mutinta Muchimba, Kalo Musukuma, Suwilanji Silwamba, Natasha Makabilo Laban, Charlie Luchen, Fraser Liswaniso, Kennedy Chibesa, Cynthia Mubanga, Kapambwe Mwape, Michelo Simuyandi, Adam F. Cunningham, David A Sack, Samuel Bosomprah

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Vibrio Cholerae; Shanchol Vaccine; Immunogenicity; HIV; Waning; Cholera Priority Areas

Online: 9 February 2024 (11:38:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2126.v1

Percutaneous Retrograde Trans-gluteal Embolization Of Type 2 Endoleak Causing Iliac Aneurysm Enlargement After Endovascular Re-pair: Case Report And Literature Review

Andrea Esposito, Rocco Pasqua, Danilo Menna, Antonio Nicola Giordano, Giulio Illuminati, Vito D’Andrea

Subject: Medicine And Pharmacology, Surgery Keywords: Endoleak; Internal iliac artery; Endovascular aortic repair; Endovascular technique; Superior gluteal artery; Embolization.

Online: 30 January 2024 (15:19:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1087.v1

Clinicopathological Assessment of Thyroid Cancer Patients Re-ferred to Imam Khomeini Hospital of Sari from Early March 2014 to Late March 2021

Ehsan Zaboli, Seyed Mohammad Mahdi Ghaffari hamedani, , Seyedeh Marziye Movahedirad, Farshad Naghshvar, Pouria Ebrahimi, Safieh Ebrahimi, Mahasti Babaeian, Saman Rezaei, Akbar Hedayatizadeh Omran, Reza Alizadeh Navaei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Thyroid carcinoma; Prevalence; Endocrine cancers; Clinical characteristics; Pathological charac-teristics

Online: 15 January 2024 (07:14:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0566.v1

What Does a KAP Survey Reveal About the Awareness Re-garding Leishmaniasis among the Community of an Endemic Area in Sri Lanka

Mayumi Manamperi, Prabuddhika Kandegedara, Isuru Chamara Lakmal Zoysa, Ishara Jayamanna, Gethanajana Perera, N. D. Asha Dilrukshi Wijegunawardana

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Awareness; KAP survey; Leishmaniasis; neglected tropical Diseases; Questionnaire; Socio-economic factors; Vector borne diseases

Online: 14 October 2023 (20:24:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0350.v1

Increasing Efficiency in the Field Water Re-injection during Mature Hydrocarbon Reservoirs Water-Flooding, Case Study from the Sava Depression, Northern Croatia

Tomislav Malvić, Josip Ivšinović, Josipa Velić, Jasenka Sremac, Uroš Barudžija

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: water injection; efficiency; sandstones; Neogene; Croatia

Online: 26 December 2019 (02:41:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0270.v1

Scaling of Measure Fluctuations on a Flapping Flag Device in the Open Channel Around a Cylinder At $Re=10^4$ : Taylor's Law Approach

Samuele De Bartolo, Massimo De Vittorio, Antonio Francone, Francesco Guido, Elisa LEONE, Vincenzo Mariano Mastronardi, Andrea Notaro, Giuseppe Roberto Tomasicchio

Subject: Engineering, Automotive Engineering Keywords: sensors technologies; sensor systems for water flow; hydrodynamics monitoring of rivers; hydraulics; MEMS; Fluid-structure interactions

Online: 14 January 2021 (13:15:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1681.v1

Re-inventories at two study sites in the Oberpfalz (Bavaria, Germany): Increase in RWA nests, herb biodiversity and dead wood in sustainably managed forests

Gabriele M. Berberich, Martin B. Berberich

Subject: Environmental And Earth Sciences, Ecology Keywords: re-inventory; red wood ants; dead wood; woodpecker; forest habitat; tree age; tree species; natural restocking, GeoBio-Interactions; Erbendorfer fault line

Online: 29 February 2024 (10:01:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0337.v1

A New Approach to the Preparation of Stable Oxide-Composite Cobalt-Samarium Catalysts for the Production of Hydrogen by Dry Re-Forming of Methane

Alexey S. Loktev, Alexey G. Dedov, Veronika A. Arkhipova, Mikhail A. Bykov, Alexey A. Sadovnikov, Kirill A. Cherednichenko, Georgy A. Shandryuk

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: heterogeneous catalysis; hydrogen; synthesis gas; dry reforming of methane; cobalt-samarium oxide catalysts

Online: 5 July 2023 (13:55:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1621.v1

Heteroaromatization of Coumarin Part I: Design, Synthesis, Re-Actions, Antitumor Activities of Novel of Chromen-3-Yl-Pyridine and Chromen-3-Yl-Naphthyridine Derivatives

Ashraf hassan fekry Abdelwahab

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 3-acetylcoumarin-2one; aromatic aldehydes; malononitrile; ethyl cyanoacetate; Acetic anhydride; carbon disulphide; and antitumor activities

Online: 23 May 2023 (08:29:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0250.v1

“Neuro-Fiber Mapping”: An Original Concept of Spinal Cord Neural Network Spatial Targeting using Live Electrostimulation Mapping to (Re)explore the Conus Medullaris Anatomy

Philippe Rigoard, Maarten Moens, Lisa Goudman, Tom Le Tutour, Michel Rochette, Jonathan Dany, Mohamed Et Talby, Manuel Roulaud, Rémi Hervochon, Amine Ounajim, Kévin Nivole, Romain David, Maxime Billot

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: anatomy; neuroanatomy; conus medullaris; Multicolumn Spinal Cord Stimulation (SCS); soma-totopy; dorsal columns; Computerized Electrical Modeling; Neuro-Fiber-Mapping; super-selective spinal cord stimulation

Online: 18 October 2022 (05:29:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0580.v1

Physical Activity, Mental Health and Wellbeing of Irish Adolescents during Covid-19 Restrictions. A Re-Issue of the Physical Activity and Wellbeing Study (PAWS)

John Murphy, Bronagh McGrane, Mary Rose Sweeney

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Exercise; Sport; Team Sport; Resilience; Identity; Health; School

Online: 26 July 2021 (14:24:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0223.v1

4-Acetyl-antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-Like Phenotypes and Chemoresistance of Colorectal Cancer Cells by Inducing hsa-miR-324 Re-Expression

Oluwaseun Adebayo Bamodu, Ching-Kuo Yang, David T.W. Tzeng, Kuang-Tai Kuo, Chun-Chih Huang, Li Deng, Michael Hsiao, Wei-Hwa Lee, Chi-Tai Yeh

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: 4-AAQB; SOD2; hsa-miR-324; colon cancer stem cells; chemoresistance; chemosensitivity

Online: 13 July 2018 (04:24:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0601.v1

Progress in Predicting Ames Test Outcomes from Chemical Structures: An In-depth Re-evaluation of Models from the 1st and 2nd Ames/QSAR International Challenge Projects

Yoshihiro Uesawa

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Ames test; quantitative structure activity relationship; applicability domain; in silico study; machine learning; predictive performance

Online: 8 January 2024 (10:25:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0956.v1

Review on the Chemistry of [M(NH₃)_n](XO₄)_m (M=Transition Metal, X=Mn, Tc or Re, n=1-6, m=1-3) Ammine Complexes

Raj Narain Mehrotra

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: Ammonia; ammine; crystal structure; synthesis; spectroscopy; hydrogen bond; oxidation; thermal decomposition; spinel

Online: 12 May 2023 (13:43:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0411.v1

Effect of the Addition of Re on the Microstructure and Phase Composition of Haynes 282: Ab Initio Modelling and Experi-Mental Investigation of Additively Manufactured Specimens

Antoni Wadowski, Jan S. Wróbel, Milena Koralnik, Ryszard Sitek

Subject: Engineering, Civil Engineering Keywords: ab initio calculation; short-range ordering; rhenium effect; nickel alloys; additive manufacturing

Online: 6 May 2023 (10:13:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0005.v1

A Re-Inventory After 12 Years – Increase in Red Wood Ant Nests and Woodpecker Cavities in Nests in the West Eifel Volcanic Field Despite Climatic Changes

Gabriele M. Berberich, Martin B. Berberich

Subject: Biology And Life Sciences, Insect Science Keywords: Red wood ants (Formica rufa-group); tree age classes; West Eifel Volcanic Field; herbaceous layer; woodpecker cavities; clearings; re-inventory; climate change

Online: 1 March 2023 (02:57:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0553.v1

An Overview of Research Opportunities to Increase the Impact of Nutrition Intervention Research in Early Childhood and Education Care Settings According to the RE-AIM Framework

Sze Lin Yoong, Jannah Jones, Nicole Pearson, Taren Swindle, Courtney Barnes, Tessa Delaney, Melanie Lum, Rebecca Golley, Louisa Matwiejczyk, Bridget Kelly, Erin Kerr, Penelope Love, Emma Esdaile, Dianne Ward, Alice Grady

Subject: Social Sciences, Psychology Keywords: Nutrition; family day care; intervention; implementation science; ECEC; child day care centres; RE-AIM; Public Health

Online: 27 January 2021 (10:49:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0355.v1

The Seneb´S EnigmA: Impact of a Hybrid Personal and Social Re-Sponsibility and Gamification Model-Based Practice on Motivation and Healthy Habits in Physical Education

David Melero-Canas, David Manzano-Sánchez, Daniel Navarro-Ardoy, Vicente Morales-Baños, Alfonso Valero-Valenzuela

Subject: Business, Economics And Management, Accounting And Taxation Keywords: physical activity; self-determination theory; after-school period; physical fitness; sedentary time

Online: 18 January 2021 (15:11:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0130.v1

Impact of General Anaesthesia - Guided by State Entropy (SE) and Response Entropy (RE) on Perioperative Stability in Elective Laparoscopic Cholecystectomy Patients. A Prospective Observational Randomized Monocentric Study

Anca Raluca Dinu, Alexandru Florin Rogobete, Sonia Elena Popovici, Ovidiu Horea Bedreag, Marius Papurica, Corina Maria Dumbuleu, Raluca Ramona Velovan, Daiana Toma, Corina Maria Georgescu, Lavinia Ioana Trache, Claudiu Barsac, Loredana Luca, Bettina Buzzi, Andra Maghiar, Mihai Alexandru Sandesc, Samir Rimawi, Madalin Marian Vaduva, Lavinia Melania Bratu, Paul Luminosu, Dorel Sandesc

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: state entropy; response entropy; general anaesthesia; patient safety; recovery.

Online: 10 February 2020 (15:24:34 CET)

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Study background and aims: Laparoscopic cholecystectomy is one of the most frequently performed interventions in departments of general surgery. One of the most important aims in achieving perioperative stability of these patients is diminishing the impact of general anesthesia on the hemodynamic stability and the optimization of anesthetic drug doses based on the individual clinical profile of each patient. The objective of this study is the evaluation of the impact monitoring the depth of anesthesia through Entropy (state entropy – SE and response entropy -RE) has on the hemodynamic stability and on the doses of volatile anesthetic. Material and Methods: This is a prospective, observational, randomized, monocentric study carried out between January 2019 and December 2019 in the Clinic of Anesthesia and Intensive Care from the “Pius Brînzeu” Emergency County Hospital in Timișoara, Romania. The patients included in the study were divided in two study groups; patients in Group A (target group) received multimodal monitoring that included monitoring of standard parameters and of Entropy (SE and RE), while patients in Group B (control group) only received standard monitoring. Anesthetic dose in group A were optimized to achieve a target entropy of 40-60. Results: 68 patients met the inclusion criteria and were allocated to one of the two study groups, Group A (N=43) and Group B (N=25). There were no statistically significant differences identified between the two groups for both demographical and clinical data (p>0.05). Statistically significant differences have been identified for the number of hypotensive episodes (p = 0.011, 95% CI 0.1851 to 0.7042) and for the number of episodes of bradycardia (p < 0.0001, 95% CI 0.3296 to 0.7923). Moreover, there was a significant difference in the Sevoflurane consumption between the two study groups (p = 0.0498, 95% CI -0.3942 to 0.9047). Conclusions: The implementation of the multimodal monitoring protocol that includes the standard parameters and the measurement of Entropy for determining the depth of anesthesia (SE and RE) lead to a considerable improvement in perioperative hemodynamic stability. Optimizing the doses of anesthetic drugs based on the individual clinical profile of each patient leads to a considerable decrease in drug consumption as well as to a lower incidence of hemodynamic side-effects.

Preprint ARTICLE | doi:10.20944/preprints202402.0882.v1

Oral Antibiotics Alone versus Oral Antibiotics Combined with Mechanical Bowel Preparation for Elective Colorectal Surgery: A Propensity Score-Matching Re-analysis of the iCral2 and iCral3 Prospective Cohorts.

Marco Catarci, Stefano Guadagni, Francesco Masedu, Massimo Sartelli, Leonardo Antonio Montemurro, Gian Luca Baiocchi, Giovanni Domenico Tebala, Felice Borghi, Pierluigi Marini, Marco Scatizzi

Subject: Medicine And Pharmacology, Surgery Keywords: Colorectal surgery; Mechanical bowel preparation; Oral antibiotics; Anastomotic leakage; Surgical site infections; Morbidity

Online: 16 February 2024 (07:50:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0578.v1

Evaluation of the Internal and External Validity of Social Media and Mobile Technology Driven HPV Vaccination Interventions: Systematic Review Using Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework

Matthew Asare, Braden Popelsky, Emmanuel Akowuah, Beth A. Lanning, Jane R. Montealegre

Subject: Social Sciences, Psychology Keywords: HPV, HPV vaccine; Social Media; Mobile Technology; HPV vaccine intervention; RE-AIM Framework

Online: 28 January 2021 (08:15:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1379.v1

Bt-modified transgenic rice shifted the composition and diversity of rhizosphere microbiota

Qi-Xing Huang, Yu-Liang Zhang, Yan-Hua Tan, Hua Kong, Yang Cao, Jun-Gang Wang, An-Ping Guo, Guohua Yin

Subject: Biology And Life Sciences, Food Science And Technology Keywords: genetically modified rice; microbial communities; 16S ribosomal RNA; transgenic Bt rice variety; operational taxonomic units

Online: 23 February 2024 (12:30:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0987.v1

Does Athletes' Respiratory Muscle Strength Affect Max VO2 Kinetics?

Gökhan Deliceoğlu, Veli O. Çakır, Banu Kabak, Halil Ibrahim Ceylan, Raul Ioan Muntean, Valentina Ștefănică

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Respiratory; maximal inspiratory pressure; expiratory pressure; MaxVO2; athletes

Online: 18 March 2024 (09:39:18 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202212.0518.v1

Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates With Protection Against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic

Michelle O. Mullins, Muneerah Smith, Hazel Maboreke, Andrew J. M. Nel, Ntobeko A. B. Ntusi, Wendy A. Burgers, Jonathan M. Blackburn

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immunoassay; epitope coverage; quantitative antibody binding; protein microarray; SARS-CoV-2 antibodies; humoral response; SARS-CoV-2 re-infection

Online: 27 December 2022 (10:43:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0369.v1

Cancer Screening and Treatment Delays During the COVID-19 Pandemic and the Role of Health Literacy in Care Re-Engagement: Findings from an NCI-Designated Comprehensive Cancer Center Sample

Jessica Keim-Malpass, Rick D. Vavolizza, Wendy F. Cohn, Erin M. Kennedy, Shayna L. Showalter

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Covid-19; health literacy; cancer screening; cancer care; cancer prevention

Online: 25 October 2022 (02:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0523.v1

Efficacy and Feasibility of SMS M-Health for the Detection of Adverse Events Following Immunisation (AEFIs) In re-Source-Limited Setting–The Zimbabwe Stimulated Telephone As-Sisted Rapid Safety Surveillance (Zm-STARSS) Randomised Con-Trol Trial

Priscilla Patricia Munyaradzi Nyambayo, Michael Gold, Ushma Mehta, Stephen Clark, Rumbidzai Manyevere, Libert Chirinda, Edlyne Zifamba, Tatenda Nyamandi

Subject: Medicine And Pharmacology, Other Keywords: Zimbabwe Stimulated Telephone Assisted Rapid Safety Surveillance (Zm-STARSS); mHealth active participant-centred (MAPC) Adverse Events Following Immunisation(AEFI) surveillance

Online: 30 March 2023 (03:51:08 CEST)

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Abstract Introduction: The mHealth active participant centred (MAPC) adverse events following immunisation (AEFI) surveillance is a promising area for early AEFI detection resulting in risk minimisation. Passive (spontaneous) AEFI surveillance is the backbone for vaccine pharmacovigilance, but has inherent drawbacks of under reporting, and requires strengthening with active surveillance methods. The Zimbabwe stimulated telephone assisted rapid safety surveillance (Zm-STARSS) randomized controlled trial (RCT) sought to evaluate the efficacy and feasibility of AEFI detection using a short message service (SMS) and computer assisted telephone interview (CATI) approach. Method: A multicentre Zm-STARSS RCT enrolled consented adult vaccinees or parents or guardians of children receiving vaccines, including COVID-19 vaccines, at study vaccination clinics. At enrolment study participants were randomised to either SMS-CATI group or control group. SMS prompts were sent on days 0-2 and 14 post-vaccination to SMS-CATI group to ascertain if a medical event following immunisation (MEFI) had occurred. However, no SMSs were sent to the control group. SMS-CATI group who responded “Yes” to SMS prompts were interviewed by research healthcare workers (RHCWs) who completed a CATI to determine if an MEFI/AEFI had occurred whilst an AEFI in control group was determined from passive AEFI reporting channels. The primary study outcome was the AEFI detection rate in the SMS-CATI group compared to the control group. Results: A total of 704 (31%) participants responded to the SMS prompts, with 75% (528/704) indicating “No” and 25% (176/704) "Yes” to experiencing a MEFI. However, 31% (55/176) who responded “Yes” did not complete a CATI survey, but 69% (121/176) did; and 64% (77/121) of these indicated negative to AEFI experience whilst 36% (44/121) were affirmative. There were no AEFI reported in control group participants. Zm-STARSS showed promising results in that the AEFI detection rate using SMS-CATI was 2% (44/2280) on an intention to treat cohort. Conclusion: Despite the low SMS response and CATI completion rate, we demonstrated that Zm-STARSS SMS system improves AEFI detection compared to passive AEFI surveillance. We recommend cost-effective multi-channel digital approaches for holistic pharmacovigilance to improve AEFI detection in LMICs for all vaccines.

Preprint ARTICLE | doi:10.20944/preprints202402.1125.v1

Water Quality of Eastern Mediterranean Catchments Subject to Different Environmental Pressures Employing Autonomous Unmanned Surface Vehicles (USVs)

Georgios Katsouras, Elias Dimitriou, Sotirios Karavoltsos, Stylianos Samios, Aikaterini Sakellari, Angeliki Mentzafou, Nikolaos Tsalas, Michael Scoullos

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: remote sensing; water quality; autonomous USV; inland and coastal waters; telemetric stations

Online: 20 February 2024 (11:49:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0119.v1

The Potential Threats of Spodoptera frugiperda (Lepidoptera: Noctuidae) on Tropical Economic Tree Species

Jiabao Xue, Yi Chen, Xiangyi Kong, Ruizong Jia, Xiaoqi Jiang, Jingyuan Guo, Yunling Guo, Yan Yang

Subject: Biology And Life Sciences, Forestry Keywords: Spodoptera frugiperda; woody plants; economic tree species; host plants; adaptation

Online: 4 March 2024 (10:24:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0729.v1

The Effects of Heavy Metals Pollution on Nitrogen Transformation and Volatile Organic Compounds in Paddy Soil under Different Water Management Practices

MUHAMMAD AFZAL, Sajid Muhammad, Dedong Tan, Sidra Kaleem, Arif Ali Khattak, Xiaolin Wang, Xiaoyuan Chen, Ma Liang Fang, Mo JingZhi, Niaz Muhammad, Mehmood Jan, Zhiyuan Tan

Subject: Environmental And Earth Sciences, Soil Science Keywords: Heavy metals; volatile organic compounds; N cycle; Paddy soil; Water management

Online: 13 February 2024 (10:44:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0452.v1

Solar Neutrinos Spectroscopy with Borexino Phase-II

Lino Miramonti, M. Agostini, K. Altenmueller, S. Appel, V. Atroshchenko, Z. Bagdasarian, D. Basilico, G. Bellini, J. Benziger, D. Bick, I. Bolognino, G. Bonfini, D. Bravo, B. Caccianiga, F. Calaprice, A. Caminata, S. Caprioli, M. Carlini, P. Cavalcante, F. Cavanna, A. Chepurnov, K. Choi, L. Collica, S. Davini, A. Derbin, X.F. Ding, A. Di Ludovico, L. Di Noto, I. Drachnev, K. Fomenko, A. Formozov, D. Franco, F. Gabriele, C. Galbiati, M. Gschwender, C. Ghiano, M. Giammarchi, A. Goretti, M. Gromov, D. Guffanti, C. Hagner, T. Houdy, E. Hungerford, Aldo Ianni, Andrea Ianni, A. Jany, D. Jeschke, V. Kobychev, D. Korablev, G. Korga, T. Lachenmaier, M. Laubenstein, E. Litvinovich, F. Lombardi, P. Lombardi, L. Ludhova, G. Lukyanchenko, L. Lukyanchenko, I. Machulin, G. Manuzio, S. Marcocci, J. Maricic, J. Martyn, E. Meroni, M. Meyer, M. Misiaszek, L. Papp, O. Penek, L. Pietrofaccia, N. Pilipenko, A. Pocar, A. Porcelli, G. Raikov, G. Ranucci, A. Razeto, A. Re, M. Redchuk, A. Romani, N. Rossi, S. Rottenanger, S. Schönert, D. Semenov, M. Skorokhvatov, O. Smirnov, A. Sotnikov, L.F.F. Stokes, Y. Suvorov, R. Tartaglia, G. Testera, J. Thurn, M. Toropova, E. Unzhakov, A. Vishneva, R.B. Vogelaar, F. von Feilitzsch, S. Weinz, M. Wojcik, M. Wurm, Z. Yokley, O. Zaimidoroga, S. Zavatarelli, K. Zuber, G. Zuzel

Subject: Physical Sciences, Particle And Field Physics Keywords: solar neutrinos; neutrino oscillation; Borexino

Online: 19 October 2018 (11:49:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1938.v1

DNA Aptamer raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing RAGE-induced Oxidative Stress and Inflammation in Testes of Diabetic Mice

Yusaku Mori, Michishige Terasaki, Naoya Osaka, Tomoki Fujikawa, Hironori Yashima, Tomomi Saito, Yurie Kataoka, Makoto Ohara, Yuichiro Higashimoto, Takanori Matsui, Sho-ichi Yamagishi

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: AGEs; DNA aptamer; diabetes; male infertility; sperm abnormality; testis

Online: 29 April 2024 (16:58:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1936.v1

Molecular Mechanisms and Therapeutic Potential of Gabapentin with a Focus on Topical Formulations to Treat Ocular Surface Diseases

Dario Rusciano

Subject: Ophthalmology, Medicine And Pharmacology Keywords: gabapentin; GABA; dry eye; neuropathic pain; eye drops

Online: 29 April 2024 (16:57:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1934.v1

Modified mRNA Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis Without Adverse Structural Remodeling

Min Ho Song, Jimeen Yoo, Do-A Kwon, Elena Chepurko, Sunghye Cho, Anthony Fargnoli, Roger J Hajjar, Woo JIn Park, Lior Zangi, Dongtak Jeong

Subject: Life Sciences, Biology And Life Sciences Keywords: modified mRNA (modRNA); CCN5; myocardial infarction (MI); cardiac fibrosis; heart failure (HF); left ventricular rupture

Online: 29 April 2024 (16:56:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1939.v1

Upregulation of Transferrin Receptor 1 (TfR1) at the Blood‐Brain Barrier by Valproic Acid, but Not of Glucose Transporter 1 (GLUT1) or CD98hc

Maj Schneider Thomsen, Kasper Bendix Johnsen, Lisa Greve Routhe, Charlotte LM Rasmussen, Steinunn sara Helgudottir

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: blood‐brain barrier; capillary depletion; CD98hc; cell culture; glucose transporter 1; ICP‐MS; nanoparticle; transferrin receptor; valproic acid

Online: 29 April 2024 (16:53:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1937.v1

A Comprehensive Review of MAV/06 Varicella Vaccines: Safety, Immunogenicity, and Effectiveness

Younchul Shin, Hyunji Ryu, Gwanglok Kim, Shinha Yang, Jaewoo Lee, BongKyoo Choi

Subject: Pediatrics, Perinatology And Child Health, Medicine And Pharmacology Keywords: varicella; MAV/06 strain; cost-effective vaccine; safety; immunogenicity; vaccine coverage

Online: 29 April 2024 (16:52:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1933.v1

Highly Sensitive Whole-Cell Mercury Biosensors for Environmental Monitoring

Dahlin Zevallos-Aliaga, Stijn De Graeve, Pamela Obanda-Chávez, Nicolás Arias Vaccari, Yue Gao, Tom Peeters, Daniel Guerra

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: whole‐cell biosensor; mercury detection; artisanal gold mining; environmental monitoring; bioavailable heavy metals; MerR; Tn501

Online: 29 April 2024 (16:49:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1943.v1

Antibacterial Properties of Peptide and Protein Fractions from the Cornu aspersum Mucus

Lyudmila Velkova, Aleksandar Dolashki, Ventsislava Petrova, Emiliya Pisareva, Dimitar Kaynarov, Momchil Kermedchiev, Marya Todorova, Pavlina Dolashka

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Cornu aspersum mucus; antimicrobial peptides; de novo MS/MS sequencing; proteomic analysis; mucus proteins whit antimicrobial action

Online: 29 April 2024 (16:47:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1935.v1

miR‐27a‐3p via FTO is Involved in Arsenit‐Induced Apoptosis of HT22 Cells

Qiyao Zhang, Teng Ma, Yujie Wang, Shiqing Xu, Siqi Zhao, Suhua Wang, Xiaohui Wang, Li Wang

Subject: Public, Environmental And Occupational Health, Public Health And Healthcare Keywords: miR-27a-3p; Arsenic; Apoptosis; Hippocampal

Online: 29 April 2024 (16:44:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0767.v1

Ecological Notes on Seasonal Depression Marshes in Southeast Florida, with Special Attention to Soil Modification and Interspecific Facilitation by Hypericum fasciculatum (Clusiaceae), a Woody Shrub

George King Rogers

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: freshwater marsh; microtopography; limiting similarity; environmental filter; facilitation; nurse plants; autogenic site alteration; environmental switch

Online: 29 April 2024 (16:39:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1928.v1

First Record of the Red Cornetfish Fistularia petimba Lacepède, 1803 from Amorgos Island (Central Aegean Sea; Greece) and a Review of Its Current Distribution in the Mediterranean Sea

Nefeli Tsaousi, Stefanos Kalogirou

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Fistularia petimba; Red cornetfish; Mediterranean Sea; Invasive species; NIS; Lessepsian species

Online: 29 April 2024 (15:33:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1930.v1

A Comprehensive Assessment And Classification Of Acute Lymphocytic Leukemia

Payal Bose, Samir Kumar Bandyopadhyay

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: Blood Cancer; Composite Learning; Deep Learning (DL); Hybrid Model; Acute Lymphoblastic Leukemia (ALL); Machine Learning (ML); ResNet50; Support Vector Machine (SVM)

Online: 29 April 2024 (15:32:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1931.v1

First Major Study on the Use of Derivatives by Indian Equity Mutual Funds during the Pandemic

Jaishankar Krishnamurthy, Satyendra Pratap Singh

Subject: Finance, Business, Economics And Management Keywords: Derivatives usage; COVID-19 impact; Mutual fund performance; Stock market volatility; Risk management

Online: 29 April 2024 (15:30:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1929.v1

A Comparative Morphological Study on the Characteristics of Egg Envelopes of Three Cultrinae Fishes (Cyprinidae, Teleostei) in Korea

Cheol Woo Park, Jae Goo Kim

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: zona radata; pore canals; non-structure; micropyle; Cultrinae

Online: 29 April 2024 (15:28:54 CEST)

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Three species of subfamily Cultrinae currently live in Korea, but Erythroculter erythropterus has been introduced into the Nakdonggang River and has taken over the habitat, reducing the habitat of Culter brevicauda. Only the endangered species C. brevicauda still lives in the Yeongsangang River, and it is necessary to be careful not to introduce E. erythropterus in the future. And Hemiculter eigenmanni is also found throughout the country. In order to effectively manage and conserve the species in its various habitats and against invasions, this study was initiated. The ultrastructure of the egg envelopes of three species of Cultrinae— E. erythropterus, C. brevicauda, and H. eigenmanni, inhabiting the Geumgang and Yeongsangang Rivers were observed. It was found that the zona radiata of the egg envelopes of all three species were divided into two layers–an outer and inner layer, with the outer surface having a non-structural form. This form is characteristic of fishes with muddy, stagnant habitats or spawning grounds. The number of pore canals on the surface of the egg envelopes was 83 for E. erythropterus, 75 for C. brevicauda, and 58 for H. eigenmanni per 10 ㎛2, and the thickness was 7.89±0.34 ㎛, 12.27±0.46 ㎛, and 7.42±0.24 ㎛, respectively. The shape of the micropyle demonstrated a funnel shape narrowing toward the inner diameter in all three species, and the size of the inner diameter was 6.62±0.29 (6.09~7.10) ㎛ in E. erythropterus, 4.19±0.39 (3.39~4.58) ㎛in C. brevicauda, and 3.98±0.46 (3.47~4.93) ㎛in H. eigenmanni. The differences between species were identified in the number of pore canals, thickness, and micropyle inner diameter of egg envelopes, which were species-specific. Our study revealed a morphological mechanism in the egg envelope that prevents the formation of interspecific hybrids, and these features can be taxonomic traits that clarify species names. It also provided useful data for the production (breeding) of the second generation in aquaculture.

Preprint REVIEW | doi:10.20944/preprints202404.1926.v1

Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus

Yujin Gu, Qili Zhang, Yanfang Zhao, Qun Niu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Curcumin; Type 2 diabetes mellitus; Antidiabetic activity; Molecular mechanisms

Online: 29 April 2024 (15:26:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1932.v1

The Effectiveness of Pattern Scanning Laser Trabeculoplasty as an Additional Treatment for the Patients of Open-Angle Glaucoma Receiving Full Ocular Hypotensive Medications.

Yosuke Ueno, Yusuke Haruna, Mami Tomita, Atsushi Sakai, Shogo Ogawa, Shigeru Honda

Subject: Ophthalmology, Medicine And Pharmacology Keywords: glaucoma; pattern scanning laser trabeculoplasty; full ocular hypotensive medications

Online: 29 April 2024 (15:25:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1927.v1

Design of a New Supersonic Shock Wave Generator and Application in Power Generation

Ming-Sen Hu, Uzu-Kuei Hsu

Subject: Energy And Fuel Technology, Engineering Keywords: renewable energy; high-pressure gas; supersonic shock wave; shock wave monitoring system; power generation system; automatic control process; power efficiency analysis.

Online: 29 April 2024 (15:23:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1925.v1

Spotlight on Syndecan 1 Role in Systemic Autoimmune Rheumatic Diseases: Main Actor or Guest Appearance?

Valeria Carnazzo, Francesca Gulli, Valerio Basile, Riccardo Di Santo, Benedetta Niccolini, Serena Redi, Ilaria Vinante, Cecilia Napodano, Krizia Pocino, Gian Ludovico Rapaccini, Mariapaola Marino, Gabriele Ciasca, Umberto Basile

Subject: Immunology And Allergy, Medicine And Pharmacology Keywords: SDC-1; FLC; autoimmunity; SARD; RA; SLE; biomarker

Online: 29 April 2024 (13:17:01 CEST)

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Background: Systemic autoimmune rheumatic diseases (SARDs), including Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA), are characterized by chronic inflammation and autoimmunity. Identifying reliable biomarkers is crucial for enhancing diagnosis, monitoring disease progression, and evaluating therapeutic responses. This study explores the potential of serum Syndecan-1 (SDC-1) as a biomarker for these conditions and concurrently examines its relationship with free light chain (FLC) expression levels in the same patients. Methods: A retrospective analysis was performed on serum samples from 120 patients (60 RA, 60 SLE), alongside 50 healthy donors (HD). Serum levels of κ and λ FLCs were determined by turbidimetric assay, while SDC-1 levels were measured using ELISA. Statistical analyses, including the Kruskal-Wallis test, Wilcoxon-Mann-Whitney U test, multivariable linear regression and Spearman’s correlation, were employed to compare biomarker levels across groups and to explore correlations among them. Results: Significantly increased levels of SDC-1, κ-FLC, and λ-FLC were observed in patients diagnosed with RA and SLE compared to HD (p < 0.001), while no significant differences in the κ/λ ratio were noted among the groups (p = 0.4). A statistically significant difference in subject age was also identified. However, multivariate regression analysis indicated that RA and SLE statuses are significantly associated with the levels of these markers, with minimal confounding by age. A significant correlation was observed separately in all groups between the FLC markers. Conversely, no correlation was detected between SDC-1 and FLCs, nor between these markers and age. Conclusion: Elevated serum levels of FLCs and SDC-1 in RA and SLE patients compared to healthy controls underscore their potential as biomarkers for SARDs. The findings also suggest sustained plasma cells activation, supporting the SDC-1 role in the pathogenesis of these conditions.

Preprint ARTICLE | doi:10.20944/preprints202404.1913.v1

Prevalence and Clinical Burden of Venous Thromboembolic Events (VTEs) in Contemporary Total Knee Arthroplasties (TKAs) in US Hospitals

Halil Ibrahim Bulut, Maria Jose Maestre, Daniel Tomey

Subject: Orthopedics And Sports Medicine, Medicine And Pharmacology Keywords: Total Knee Arthroplasty; Pulmonary embolism; Deep vein thrombosis; Venous Thromboembolic Events

Online: 29 April 2024 (12:30:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1922.v1

Designing Insulin Analogues with Lower Binding Affinity to Insulin Receptor than That of Insulin Icodec

Wei Li

Subject: Biophysics, Biology And Life Sciences Keywords: Insulin icodec; Binding affinity; Site-specific mutation; Receptor-mediated internalization

Online: 29 April 2024 (11:57:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1921.v1

Diversity Restated: >99.9% of Global Species in Soil Biota

Robert Blakemore

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Soil organisms; microbe; earthworm; virus; biodiversity richness; taxonomy; -omics.

Online: 29 April 2024 (11:56:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1920.v1

Implementing Effective Data Security Measures in Fintech Applications: Address the importance of and approaches to securing sensitive financial data

Dharika Kapil

Subject: Finance, Business, Economics And Management Keywords: Data Security in FinTech; Financial Technology Data Protection; Encryption Technologies in Finance; Blockchain for Financial Security; Cloud Security in FinTech; Regulatory; Frameworks in Finance; Cybersecurity Threats in FinTech; AI in Financial Security; Technological Solutions for Data Protection; FinTech Compliance and Standards; Secure Financial Transaction Methods

Online: 29 April 2024 (11:55:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1923.v1

Duckweed beyond an Efficient Plant Model System

Doni Thingujam, Karolina Marta Pajerowska-Mukhtar, M. Shahid Mukhtar

Subject: Plant Sciences, Biology And Life Sciences Keywords: Duckweed; Plant model; Phytoremediation, Sustainability, Transgenic

Online: 29 April 2024 (11:53:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1807.v1

Concrete Decisions: How Psychological Distance Influences Willingness to Engage in Risky COVID Behavior

Ceridwen Williams, Paul Rauwolf, Matt Boulter, John A. Parkinson

Subject: Behavior Sciences, Social Sciences Keywords: Psychological distance; Construal level; Behavior Change; Covid-19

Online: 29 April 2024 (11:50:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0926.v2

Effects of Training through Induced Variability on Performance in the Forehand Approach Shot in Tennis

Vinicius Oliveira, Ruperto Menayo, Juan Pedro Fuentes-García

Subject: Other, Social Sciences Keywords: Variable practice; tennis; forehand; approach net shot; ball type; tennis court

Online: 29 April 2024 (11:47:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1680.v2

Development of a Mock-up of a Smart Insole Using FSR and ADXL345

ABHISHEK MANISH LELE, DNYANESHWAR WAGHOLE, PANKAJ DHATRAK

Subject: Mechanical Engineering, Engineering Keywords: Gait Analysis; Pressure Mapping; Orientation Tracking

Online: 29 April 2024 (11:43:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1916.v1

Yolo-Chili: An Efficient Lightweight Network Model for Localization of Pepper Picking in Complex Environments

HaiLin Chen, Ruofan Zhang, Jialiang Peng, Hao Peng, Wenwu Hu, Yi Wang, Ping Jiang

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Chili Detection,Automatic Picking,Neural Network,Model Compression

Online: 29 April 2024 (11:14:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1915.v1

Numerical Analysis of Structural Vibrations in Masts. A Practical Study Applied to a 28-Meter Tugboat.

Arturo Silva-Campillo, Francisco Pérez-Arribas

Subject: Marine Engineering, Engineering Keywords: vibration; mast; bridge top; structural analysis

Online: 29 April 2024 (11:13:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1914.v1

Clarifying the Dominant Role of Crystallinity and Molecular Orientation in Differently Processed Thin Films Regioregular poly(3-Hexylthiophene)

Kumar Vivek Gaurav, Harshita Rai, Kshitij RB Singh, Shubham Sharma, Yoshito Ando, SHYAM S. PANDEY

Subject: Applied Physics, Physical Sciences Keywords: Regioregular poly(3-hexylthiophene); organic field-effect transistors; thin films; crystallinity; orientation; unidirectional floating film transfer

Online: 29 April 2024 (10:34:47 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1865.v1

Detection and Characterization of Methylated Circulating Tumor DNAs in Gastric Cancer

Seung Young Seo, Sang Hee Youn, Jin-Han Bae, Sung-Hun Lee, Sun Young Lee

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Gastric cancer; Liquid biopsy; MeDIP; Fragment

Online: 29 April 2024 (10:34:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1872.v1

Advancements in Risk Management Software for Dealers and Brokers: Discuss the Latest Technologies and Methodologies in Risk Management Software Development

Dharika Kapil

Subject: Finance, Business, Economics And Management Keywords: FinTech; risk management; artificial intelligence; machine learning; big data; blockchain; Regtech; quantum computing

Online: 29 April 2024 (10:34:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1869.v1

Assessment of the Biogenic Souring in Oil Reservoirs Under Secondary and Tertiary Oil Recovery

Hakan Alkan, Felix Kögler, Gyunay Namazova, Stephan Hatscher, Wolfgang Jelinek, Mohd Amro

Subject: Energy And Fuel Technology, Engineering Keywords: Biogenic souring; waterflooding; microbial enhanced oil recovery; souring mitigation; numerical modelling; mineral scavenging; risk management

Online: 29 April 2024 (10:34:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1875.v1

Enhancing Precision: Unveiling Individualized Treatment Effects with Advanced Computational Methods

Satish Mandavalli

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Causal Forest; Causal Net; Healthcare; Virtual Twin Random Forest

Online: 29 April 2024 (10:34:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1879.v1

Taurine Neuroprotection and Neurogenesis Effect in Chronic Ethanol Induced Rats

Patricia Rodella, Diogo Boreski, Luiz Fernando Takase, Edmo Atique Gabriel, Marcus Alexandre Mendes Luz, Chung Man Chin

Subject: Pharmacy, Medicine And Pharmacology Keywords: taurine; neuroprotection; neurogenesis; hipocampus; ethanol consumption

Online: 29 April 2024 (10:34:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1871.v1

Modeling of Electrochemical Impedance of Fuel Cell Based on the Novel Nanocomposite Membrane

Mariia Zhyhailo, Iryna Yevchuk, Fedir Ivashchyshyn, Оksana Demchyna, Piotr Chabecki, Natalia Babkina, Tetiana Shantaliy

Subject: Electrochemistry, Chemistry And Materials Science Keywords: fuel cell; impedance spectroscopy; Nyquist diagram; SAXS; proton conductivity; composite membrane

Online: 29 April 2024 (10:34:09 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1867.v1

Chirality Engineering-Regulated Liquid-Liquid Phase Separation of Stress Granules and Its Role in Chemo-Sensitization and Side Effect Mitigation

Ruxuan Ma, Liuting Zheng, Chengjin Ding, Da Huo, Huiyue Zhao, Hao Zhang

Subject: Biomaterials, Chemistry And Materials Science Keywords: nanomedicine; chirality; stress granules; liquid-liquid phase separation; chemotherapy

Online: 29 April 2024 (10:34:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1908.v1

What Is A Disease for Doctors? A Realist Thematic Analysis and Implications for Medical Education

Fabrizio Consorti, Rossella Melcarne, Domenico Pisanelli, Chiara Scorziello, Laura Giacomelli

Subject: Clinical Medicine, Medicine And Pharmacology Keywords: disease; illness; philosophy of medicine; critical realism

Online: 29 April 2024 (10:33:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1890.v1

Nanostructured Biomaterials in Tumor Tissue Engineering: Regenerative Medicine and Immunotherapies

Athina Angelopoulou

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: tissue engineering; cancer; immunotherapy; 3D scaffolds; biomaterials

Online: 29 April 2024 (10:33:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1892.v1

Vertical Meaning: Interpersonal Data in Quantum Circuits via Japanese Honorifics

Ryder Dale Walton

Subject: Other, Computer Science And Mathematics Keywords: Quantum Natural Language Processing; QNLP; Systemic Functional Linguistics; SFL; Japanese; honorifics; interpersonal metafunction; lambeq; category theory; Quantum Machine Learning; QML

Online: 29 April 2024 (10:31:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1900.v1

The Weighty Responsibility of Creating AI Navigating Control and Ethics

Budee U Zaman

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: ; technology based,artificial intelligence, founding rules

Online: 29 April 2024 (10:30:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1902.v1

Genetic Gain and Inbreeding Rate in Different Simulated Genomic Selection Schemes for Grain Yield and Oil Content in Safflower

Huanhuan Zhao, Majid Khansefid, Zibei Lin, Matthew Hayden

Subject: Plant Sciences, Biology And Life Sciences Keywords: genetic gain; inbreeding rate; safflower; simulation; grain yield; seed oil content

Online: 29 April 2024 (10:28:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1860.v1

Exploring The Model-View-Controller (MVC) Architecture: A Broad Analysis of Market and Technological Applications

Sabina Necula

Subject: Information Systems, Computer Science And Mathematics Keywords: Model-View-Controller (MVC); Software Architecture; Web Development Frameworks; Enterprise Software Applications; AI Integration in Software; Machine Learning and MVC; Educational Tools in Software Engineering; Model-View-ViewModel (MVVM); JavaScript Frameworks; Agile Development

Online: 29 April 2024 (10:25:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1861.v1

A Comparative Assessment of Drinking Water Preferences among University Students in Qatar: A Cross-Sectional Study

Razi Mahmood, Norr Hassan, Ashraf Chamseddine, Ravi Rangarajan, Rami Yassoub

Subject: Public, Environmental And Occupational Health, Public Health And Healthcare Keywords: bottled water; tap water; drinking water; university students; attitude; preferences; cross-sectional study

Online: 29 April 2024 (10:25:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1888.v1

Visual Data and Pattern Analysis for Smart Education: A Robust Drl-Based Early Warning System for Student Performance Prediction

Wala Bagunaid, Naveen Chilamkurti, Ahmad Salehi Shahraki, Saeed Bamashmos

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: E-FedCloud; Cycle General Adversarial Network (CGAN); Majority Voting-Based Multi-Objective Clustering (MV-MOC); Duelling Deep Q Network (ID2QN).

Online: 29 April 2024 (10:25:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1870.v1

MYµALBUMIN: A Point-of-Care Medical Device for Determination of Albumin-Creatinine Ratio (uACR) in Random Urine Samples as A Marker of Nephropathy

Nadda Muhamad, Napaporn Yongvises, Tullayakorn Plengsuriyakarn, Wanchai Meesiri, Wanna Chaijaroenkul, Kesara Na-Bangchang

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Albumin; Albumin-Creatinine ratio; Creatinine; Microalbumin; Point-of-Care medical device

Online: 29 April 2024 (10:25:15 CEST)

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Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the world's population. Monitoring urine albumin and creatinine ratio (µACR) has become the gold standard for nephropathy diagnosis and control. The objective of the present study was to develop a simple, accurate, sensitive, and rapid point-of-care test (PoCT) device - MYμALBUMIN that community healthcare professionals can use in resource-limited facilities and by patients in their own homes for screening the risk and monitoring the progress of CKD. Albumin and creatinine concentrations in urine samples were determined using spectrophotometric dye (tetrabromophenol blue)-binding and colorimetric Jaffe’assay, respectively. Urine samples were diluted with distilled water (1:80) and mixed separately with albumin and creatinine reaction mixture. The creatinine reaction was incubated at room temperature (25oC) for 30 minutes before analysis. Optical density (OD) was measured at the wavelengths of 625 nm (albumin) and 515 nm (creatinine). All calibration curves (2-60 mg/L and 0.25-2 mg/dL for albumin and creatinine) yielded linear relationships with correlation coefficients (r2) of > 0.999. Good accuracy (%DMV < + 2.88%) and precision (%CV < 3.0%) were observed from both the intra- or interday assays for the determination of albumin and creatinine by MYµALBUMIN. The limit of quantification (LOQ) of albumin and creatinine in urine samples determined by MYµALBUMIN and laboratory spectrophotometer were 2 mg/L and 0.1 mg/dL, respectively, using 37.5 μL urine samples. The device was well applied with clinical samples from 13 CKD patients. The median (range) of %DMV of the central (hospital) laboratory method (immune-based assay) was 3.18 (-10.11 to 14.12)%, with a high correlation coefficient (r2 >0.99). In conclusion, MYμALBUMIN showed satisfactory test performance in terms of accuracy, reproducibility, sensitivity, and specificity. The device would have significant economic benefits besides obviously improving clinical decision-making processes.

Preprint ARTICLE | doi:10.20944/preprints202404.1884.v1

Investigating Effective Factors in Solving Partial Differential Equations using Deep Learning Techniques

Parastoo Kabi-Nejad

Subject: Mathematics, Computer Science And Mathematics Keywords: Partial Differential Equations; Machine learning; Neural Networks; Computational Modeling; Feature Identification

Online: 29 April 2024 (10:25:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1864.v1

Poor Work Ability Is Associated with Workplace Violence in Nurses. A Longitudinal Study

Nicola Magnavita, Igor Meraglia

Subject: Nursing, Public Health And Healthcare Keywords: ableism; ageism; disability management; health surveillance; health promotion; injury; occupational health; social support; psychosocial stress; bullying

Online: 29 April 2024 (10:25:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1862.v1

A Systemic Model for Resilience and Time Management in Healthcare Academia

Maria Antoniadou, Rallis Antoniadis

Subject: Business And Management, Business, Economics And Management Keywords: Systemic approach; systems management; academia; academicians; time management; procrastination; prioritization; perfectionism; timewasters; systemic tools

Online: 29 April 2024 (10:25:02 CEST)

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Academics in healthcare grapple with the challenge of efficiently managing time while addressing diverse roles and responsibilities, leading to heightened levels of anxiety and stress within the academic community. The primary objective of this study is to offer a sustainable and systemic solution to the prevalent time-management challenges in healthcare academia, through the development of a predictive model. Employing systemic analysis software and adopting a systemic management approach, we crafted a model to address academic time-management concerns. The dynamics of time allocation for academicians are governed by three fundamental pillars: teaching, research, and administrative tasks. Significantly prioritizing administrative tasks depletes valuable academic time, making time management within academia excessively costly. This occurs as highly skilled individuals find themselves diverted towards administrative duties at the expense of their academic roles diminishing resilience levels. The proposed Timebooster Academic Systemic Model (TASM) advocates for the cultivation of soft skills in academia, en-compassing prioritization, seeking assistance, and addressing tendencies of perfectionism and procrastination. Additionally, TASM recommends the implementation of full automation, delegation of administrative responsibilities, and the mitigation of both overt and covert time-consuming elements. Furthermore, TASM reports on the pivotal role of the academic resilient manager-leaders, who actively contribute to their own satisfaction and academic growth by enhancing collaboration and teamwork. Time-management challenges emerge as a critical determinant of academic well-being and resilience. Systemic models, exemplified by TASM, offer a valuable framework for investigating prioritization concerns, identifying administrative impediments in academic processes, and managing low-value time-consuming elements. The TASM model, along with the systemic philosophy underpinning its design, presents an avenue for advancing the exploration of time-management phenomena within the context of healthcare academia.

Preprint ARTICLE | doi:10.20944/preprints202404.1878.v1

Development of a Mini-Genome Assay for Species a Rotaviruses

Ola Diebold, Colin Peter Sharp, Blanka Tesla, Hou Wei Chook, Paul Digard, Eleanor R Gaunt

Subject: Virology, Biology And Life Sciences Keywords: rotavirus; minigenome; RNA-dependent RNA polymerase; reporter assay

Online: 29 April 2024 (10:24:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1859.v1

A Streaming Algorithm for a Fast, Robust, and Memoryless Median Estimation on Sensor Data

Ariel Burman, Jordi Solé-Casals, Sergio E. Lew

Subject: Probability And Statistics, Computer Science And Mathematics Keywords: median; estimator; on-line; neural recordings

Online: 29 April 2024 (10:24:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1909.v1

Synthesis, Characterization and Analytical Prospects of Cellulose-Derived Nanoparticles of Ferric-Oxide (Fe₂O₃/Cellulose) and Copper-Oxide (CuOx)

Sana Ullah Khan, Ali Khan, Amir Hassan

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: nanocomposites; cellulose-derived NPs; (Fe₂O₃/cellulose); (CuOx-NPs) and SEM

Online: 29 April 2024 (10:21:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1898.v1

Street Tree Designs for Particulate Matter Reduction in Glasgow: A Supportive Approach for Urban Planning

Chanodi Ratnayake, Rohinton Emmanuel

Subject: Transportation Science And Technology, Engineering Keywords: urban air pollution; particulate matter; street trees; nature-based solutions; urban street canyon; ENVI-met

Online: 29 April 2024 (10:17:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1912.v1

Assessing the Impact of Urban Expansion on the Urban Environment in Riyadh City (2000–2022) Using Geospatial Techniques

Shaykhah Mohammed Alajizah, Hamad Ahmed Altuwaijri

Subject: Geography, Environmental And Earth Sciences Keywords: urban expansion; urban environment; geospatial technologies; remote sensing; Thermal Environmental Index

Online: 29 April 2024 (10:12:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1911.v1

Understanding Preferences of Indian Three-Wheeler Drivers for Electric Vehicles

Zijin Zhou, Lingfang Shao

Subject: Architecture, Building And Construction, Engineering Keywords: Electric three-wheeler; Intermediate Public Transport (IPT); Discrete Choice Model; Driver Preferences; Transition Challenges; Market Penetration Strategies

Online: 29 April 2024 (10:07:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1899.v1

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

Norberto A. Guzman, Andrea Guzman

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: COVID-19; immunoaffinity capillary electrophoresis; lateral flow immunoassays; point-of-care testing; respiratory disease biomarkers; SARS-CoV-2 virus; sputome; sputum proteomics

Online: 29 April 2024 (10:06:53 CEST)

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Many ailments can be diagnosed while they are asymptomatic, meaning that the patient has no signs or symptoms of a progressing disease. If caught in their initial stage of formation, these maladies can be effectively treated, leading to successful outcomes; curative therapies can halt illnesses from advancing, thus improving the quality of life, and long-term survival of the patient. Still cutting-edge upgrades in precision technologies are necessary for early, reliable, affordable, and rapid disease detection, but also are vital for the well-being of people and the future of global public health. The emerging role and utility of non-invasive and repeatable diagnostic test approaches for detection of health conditions has been liquid biopsies based on genomic biomarkers. As such, biological fluids permit any measurable molecular indicator or signature (e.g., proteins), to provide valuable information on individual’s wellness and/or disease. Among the bodily secretions used for non-invasive diagnostics is sputum, a complex viscous gel-like biopolymeric network, that has gained growing recognition as a rich source of biomarkers of airway infections, pulmonary diseases, and serves as a determinant to reveal other illnesses. As per the World Health Organization, the burden of respiratory conditions is exacerbated by factors, ranging from considerable subjection to air pollution and occupational contaminants, to tobacco smoking and second-hand smoke, in addition to poor socio-economic status. Due to the likely increase of these determinants, respiratory tract ailments are on the rise, affecting the health of many individuals, in addition to putting stress on healthcare facilities and services worldwide. We therefore highlight the need to use expectorated or induced sputum specimens as a routine sample source for testing valuable protein biomarkers to diagnose these chronic maladies, to predict inflammation and disease progression, as well as monitor the effectiveness of treatments. Further, we discuss the urgency for fast and reliable point-of-care methods to detect and quantify crucial protein biomarkers in sputum specimens, and limitations faced when dealing with their complex matrices.

Preprint CASE REPORT | doi:10.20944/preprints202404.1910.v1

Exploring the Spatio-Temporal Evolutionary Characteristics of Paomo Restaurants in Xi’an’s Central Urban Area Through POI Data Analysis

Dawei Yang, Ping Xu, Xiaojuan Yang

Subject: Geography, Planning And Development, Social Sciences Keywords: POI Data, Paomo Restaurants, Spatio-temporal Evolution Characteristics, Xi'an

Online: 29 April 2024 (10:06:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0510.v3

Retail and Consumer Behavior: Bibliometrics Review

Quintessa Huynh, Hani Tran

Subject: Marketing, Business, Economics And Management Keywords: ; consumer behavior; retail; VOSviewer; bibliometrics; research community

Online: 29 April 2024 (10:04:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1895.v1

Elevated Immunoglobulin E Serum Levels: Possible Underlying Factors That Can Cause an Inborn Error of Immunity in the Pediatric Population with Recurrent Infections

Sînziana Oprițescu, Viorela Nițescu, Daniela Cîrnațu, Svetlana Trifunschi, Melania Munteanu, Mihaela Golumbeanu, Dora Boghițoiu, Adriana Maria Dărăban, Elena Iuliana Ilie, Elena Moroșan

Subject: Immunology And Allergy, Medicine And Pharmacology Keywords: hyper-IgE; HIES; infectious diseases; clinical manifestation

Online: 29 April 2024 (10:02:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1874.v1

Cytokine Profiling and Puberty Enhancement Post Altrenogest Feeding in Pre Pubertal Murrah Buffalo (Bubalus bubalis) Heifers

Sneha S H, Prahlad Singh, Navdeep Singh Ratta, Chanchal Singh, Mrigank Honparkhe

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: AMH; buffalo; cytokines; estrogen; heifers; progesterone; puberty; Karl Pearson correlation

Online: 29 April 2024 (10:00:25 CEST)

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Cytokine and AMH profiling were done in prepubertal Murrah buffalo heifers post-progesterone supplementation and co-synchronization protocol. Cytokines: IFNγ, IL6, IL1, IL13, TNFα, and TGFβ, and, AMH, Progesterone and Estrogen hormone estimations were done. Ovarian follicular pattern and fertility outcome were recorded. Eighteen prepubertal heifers, 15-17 months of age, 250-300 kg BWt were randomly divided into 3 groups, Group1: n=6, supplemented with altrenogest 0.044mg/kg/day/heifer orally for 14 days along with Co-synch programme; Group2: n=6, administered CIDR for 14 days and co-synch programme, Group3: n=6, received co-synch programme. Ultrasonography was done to ovarian follicle status on respective days of sampling. Pregnancy diagnosis was done around 45 and 60 post-AI. Estradiol 17-β level remained constant in altrenogest group, CIDR implanted and Control groups during the Progesterone treatment and Co-synch treatment. Estradiol levels during Co-synch were significantly less on day 9 of Co-synch (14.41 ± 1.97 pg/mL) than day 0 and on day7 in pre pubertal buffalo heifers in altrenogest group. However, no significance was observed in other groups. Progesterone levels in buffalo heifers subjected to synchronisation protocols varied significantly (P< 0.05) on day 7 of P4 treatment between altrenogest supplemented and CIDR implanted groups, as well as, Co-synch groups. Supplementation of altrenogest showed a significant (P= 0.043) increase in Progesterone levels by day 14 of altrenogest treatment. Progesterone varied significantly in all Groups on day 9 of co synch protocol [ Group 1 (P= 0.02), Group 2 (P= 0.041) and Group 3 (P= 0.007)]. Cytokine IFN-γ showed high correlation with progesterone, indicating the role of IFN-γ in puberty in buffalo heifers (r= 0.626, P< 0.01). AMH had a significant positive correlation supplemented with altrenogest with IFN-γ (r= 0.673, P< 0.01) and TGF-β (r= 0.463, P< 0.01), whereas, with TNF-α it was a negatively correlated (r= -0.34, P< 0.05). Based on Karl Pearson correlation coefficients, IL-13 and TGF-β could be considered as markers for puberty in buffalo heifers.

Preprint ARTICLE | doi:10.20944/preprints202404.1894.v1

Design and Implementation of AI-Based Judicial Big Data Intelligent Service Platform

Zhangsheng Sun, Wenhao Li, Mengru Yu, Xiaohan Yang, Muqayam Nurmaithi

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: artificial intelligence technology; judicial services; big data analysis; model optimization

Online: 29 April 2024 (09:58:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1893.v1

Disturbance Observer-Based Anti-shock Controller for Laser Beam Steering Systems

Jung-Gon Kim

Subject: Control And Systems Engineering, Engineering Keywords: laser beam steering; fast-steering mirror; tip-tilt control system; anti-shock controller; disturbance observer

Online: 29 April 2024 (09:56:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1891.v1

[Fe^IIICl(TMPPH₂)][Fe^IIICl₄]₂: A Stand-Alone Molecular Nanomedicine that Induces High Cytotoxicity by Ferroptosis

Xiao Wang, Jia-Hao Feng, Chun-Mei Zeng, Ze-Sheng Zhang, Feng-Lin Cao, Wen-Hua Zhang, Jin-Xiang Chen, Yiming Mao, David James Young

Subject: Inorganic And Nuclear Chemistry, Chemistry And Materials Science Keywords: single-molecular nanomedicine; porphyrin ligand; chemodynamic therapy; ferroptosis; breast cancer therapy

Online: 29 April 2024 (09:55:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1873.v1

Telecommunication Infrastructure Construction and Development to Impact of Innovation and Development in China: A Panel Data Approach

Kaidi Yang, Shaorong Li

Subject: Area Studies, Social Sciences Keywords: telecommunication infrastructure; innovation development; regional disparities

Online: 29 April 2024 (09:55:46 CEST)

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