Version 1
: Received: 19 March 2024 / Approved: 21 March 2024 / Online: 21 March 2024 (12:01:45 CET)
How to cite:
Baratta, P.; De Sensi, F.; Cresti, A.; Sposato, B.; Re, F.; Spargi, G.; Limbruno, U. Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with ARDS Related to SARS-CoV-2 Infection. Preprints2024, 2024031276. https://doi.org/10.20944/preprints202403.1276.v1
Baratta, P.; De Sensi, F.; Cresti, A.; Sposato, B.; Re, F.; Spargi, G.; Limbruno, U. Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with ARDS Related to SARS-CoV-2 Infection. Preprints 2024, 2024031276. https://doi.org/10.20944/preprints202403.1276.v1
Baratta, P.; De Sensi, F.; Cresti, A.; Sposato, B.; Re, F.; Spargi, G.; Limbruno, U. Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with ARDS Related to SARS-CoV-2 Infection. Preprints2024, 2024031276. https://doi.org/10.20944/preprints202403.1276.v1
APA Style
Baratta, P., De Sensi, F., Cresti, A., Sposato, B., Re, F., Spargi, G., & Limbruno, U. (2024). Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with ARDS Related to SARS-CoV-2 Infection. Preprints. https://doi.org/10.20944/preprints202403.1276.v1
Chicago/Turabian Style
Baratta, P., Genni Spargi and Ugo Limbruno. 2024 "Prognostic Value of Response to Inhaled Nitric Oxide Administration in Patients with ARDS Related to SARS-CoV-2 Infection" Preprints. https://doi.org/10.20944/preprints202403.1276.v1
Abstract
Background: The role of inhaled Nitric Oxide (iNO) in managing Acute Respiratory Distress Syndrome Covid-19 related (C-ARDS) is debatable. The study aimed to analyze the effect of iNO administration in patients with persistent severe hypoxia and Intensive Care Unit (ICU) mortality.
Methods: This retrospective study included 98 consecutive critically ill patients with C-ARDS admitted to ICU from 1 October 2020 to 31 October 2021.
Results: Of these patients, 28% had received iNO. Twelve (44.4%) were responders. Kaplan-Mayer plot shows mortality was higher in non-responders (86.6 vs 25.0%). Non-response to iNo was the most important predictive value (p. 0.01). The Receiver Operating Characteristic (ROC) curve for a percentage increase in PaO2 from baseline confirmed that it had a higher predictive value for in-hospital survival. A value of 19% can predict the death event with a sensitivity of 81.8% and a specificity of 81.2%.
Conclusions: Therefore, we propose to use iNO as a vasoreactivity test for prognostic stratification in patients with persistent severe hypoxia.
Keywords
Inhaled nitric oxide; ARDS; Sars CoV-2; Vasoreactivity Test
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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