Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of the Internal and External Validity of Social Media and Mobile Technology Driven HPV Vaccination Interventions: Systematic Review Using Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework

Version 1 : Received: 27 January 2021 / Approved: 28 January 2021 / Online: 28 January 2021 (08:15:38 CET)

A peer-reviewed article of this Preprint also exists.

Asare, M.; Popelsky, B.; Akowuah, E.; Lanning, B.A.; Montealegre, J.R. Internal and External Validity of Social Media and Mobile Technology-Driven HPV Vaccination Interventions: Systematic Review Using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework. Vaccines 2021, 9, 197. Asare, M.; Popelsky, B.; Akowuah, E.; Lanning, B.A.; Montealegre, J.R. Internal and External Validity of Social Media and Mobile Technology-Driven HPV Vaccination Interventions: Systematic Review Using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework. Vaccines 2021, 9, 197.

Journal reference: Vaccines 2021, 9, 197
DOI: 10.3390/vaccines9030197

Abstract

Social media HPV vaccination interventions show promise for increasing HPV vaccination rates. An important consideration for the implementation of effective interventions into real-world practice in the translation potential, or external validity, of the intervention. To this end, we conducted a systematic literature review to describe the current body of evidence regarding the external validity of social media HPV vaccination-related interventions. Constructs related to external validity were based on the RE-AIM (reach, effectiveness, adoption, implementation, maintenance) framework. Seventeen articles published between 2006 and 2020 met inclusion criteria. Three researchers independently coded each article using a validated RE-AIM (reach, effectiveness/efficacy, adoption, implementation, maintenance) framework. Discrepant codes were discussed with a fourth reviewer to gain consensus. Of these 17 studies, three were pilot efficacy studies, 10 were RCTs to evaluate effectiveness, one was a population-based study, and three did not explicitly state which type of study was conducted. Reflecting this distribution of study types, across all studies the mean level of reporting RE-AIM dimensions varied with reach recording 90.8%, effectiveness (72.1%), adoption (40.3%), implementation (45.6%), and maintenance (26.5%). This review suggests that while the current HPV vaccination social media-driven interventions provide sufficient information on internal validity (reach and effectiveness), few have aimed to gather data on external validity needed to translate the interventions into real world implementation. Our data suggest that implementation research is needed to move HPV vaccination-related interventions into practice. Included in this review are recommendations for enhancing the design and reporting of these HPV vaccination social media-related interventions.

Subject Areas

HPV, HPV vaccine; Social Media; Mobile Technology; HPV vaccine intervention; RE-AIM Framework

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