Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in 2018 in Touba City, Senegal

Idrissa Dieng
* ,
Cheikh Fall
,
Aboubacry Gaye
,
Mamadou Aliou Barry
,
Oumar Faye
,
Marie Henriette Ndione
,
Mamadou Diop
,
Ousmane Faye
,
Cheikh Loucoubar
ORCID logo ,
Amadou Sall
Version 1 : Received: 7 October 2022 / Approved: 10 October 2022 / Online: 10 October 2022 (11:21:49 CEST)

How to cite: Dieng, I.; Fall, C.; Gaye, A.; Barry, M.A.; Faye, O.; Ndione, M.H.; Diop, M.; Faye, O.; Loucoubar, C.; Sall, A. Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in 2018 in Touba City, Senegal. Preprints 2022, 2022100126. https://doi.org/10.20944/preprints202210.0126.v1 Dieng, I.; Fall, C.; Gaye, A.; Barry, M.A.; Faye, O.; Ndione, M.H.; Diop, M.; Faye, O.; Loucoubar, C.; Sall, A. Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in 2018 in Touba City, Senegal. Preprints 2022, 2022100126. https://doi.org/10.20944/preprints202210.0126.v1

Abstract

Dengue virus (DENV) was detected in Senegal in 1979 for the first time. Since 2017, unprecedented frequent occurrence of DENV outbreaks was noticed yearly. In this context, epidemiological and molecular evolution data are paramount to decipher virus diffusion route. In the current study, a dengue outbreak occurred in Senegal in 2018 in the context of the largest religious gathering with 263 confirmed DENV cases out of 832 collected samples, including 25 life-threatening cases and 2 deaths. It was characterized by a co-circulation of dengue serotypes 1 and 3. Phylogenetic analysis based on the E gene revealed that the main detected serotype in Touba city was DENV-3 and belonged to Genotype III. Bayesian phylogeographic analysis was performed and suggested one viral introduction around 2017.07 (95 % HPD = 2016.61 – 2017.57) followed by cryptic circulation before identification of the first case on 01 October 2018. DENV-3 strains are phylogenetically related, with strong phylogenetic links between strains retrieved from Burkina Faso and West African countries. These phylogenetic data substantiate epidemiological data of the DENV-3 origin and spread between African countries and subsequent diffusion after religious mass events. The study also highlighted the usefulness of the Mobile Laboratory during outbreak response allowing rapid diagnosis resulting in improved patient management.

Keywords

Dengue; Touba; Mass gathering; Field Investigation; Mobile laboratory; Phylogeny; Phylogeography

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.