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Preprint ARTICLE | doi:10.20944/preprints202107.0626.v1

A High Efficacy DNA Vaccine Against Tilapia Lake Virus in Nile Tilapia (Oreochromis niloticus)

Nai-tong Yu, Wei-wei Zeng, Jian-hua Wang, Yu-liang Zhang, Xiu-chun Zhang, Zhi-xin Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tilapia; negative-sense RNA virus; Tilapia lake virus; DNA vaccine

Online: 28 July 2021 (11:11:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0212.v1

Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

Tessa Nelemans, Marjolein Kikkert

Subject: Biology And Life Sciences, Virology Keywords: positive-sense single-stranded rna viruses; innate immune evasion; type 1 interferon; viral pathogenesis; type 3 interferon

Online: 18 September 2019 (17:12:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0358.v1

Full-Length Genomic RNA of Foot-and-Mouth Disease Virus is Infectious for Cattle by Injection

Hanna Keck, Benedikt Litz, Bernd Hoffmann, Julia Sehl-Ewert, Martin Beer, Michael Eschbaumer

Subject: Biology And Life Sciences, Virology Keywords: Foot-and-mouth disease virus; safe sample transport; single-stranded positive-sense RNA; TRIzol extraction; naked RNA; infectivity; RNA transfection; lipofectamine; self-transfection; BHK cells

Online: 25 July 2022 (08:14:51 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202003.0021.v2

Bottleneck, Isolate, Amplify, Select (BIAS) as a Mechanistic Framework for Intracellular Population Dynamics of Positive Sense RNA Viruses

Feng Qu, Limin Zheng, Shaoyan Zhang, Rong Sun, Jason Slot, Miyashita Shuhei

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: virus; population bottleneck; positive sense RNA virus; evolution

Online: 1 October 2020 (08:28:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0172.v4

Protein-Encoding RNA-to-RNA Information Transfer in Mammalian Cells: Principles of RNA-Dependent mRNA Amplification

Vladimir Volloch

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA-dependent amplification of mammalian mRNA; physiologically occurring intracellular PCR, iPCR; RNA-dependent RNA polymerase, RdRp; chimeric RNA; sense-strand RNA; antisense-strand RNA

Online: 12 June 2019 (12:21:59 CEST)

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The transfer of protein-encoding genetic information from DNA to RNA to protein, a process formalized as the “Central Dogma of Molecular Biology”, has undergone a significant evolution since its inception. It was amended to account for the information flow from RNA to DNA, the reverse transcription, and for the information transfer from RNA to RNA, the RNA-dependent RNA synthesis. These processes, both potentially leading to protein production, were initially described only in viral systems, and although RNA-dependent RNA polymerase activity was shown to be present, and RNA-dependent RNA synthesisfound to occur, in mammalian cells, its function was presumed to be restricted to regulatory. However, recent results, obtained with multiple mRNA species in several mammalian systems, strongly indicate the occurrence of protein-encoding RNA to RNA information transfer in mammalian cells. It can result in the rapid production of the extraordinary quantities of specific proteins as was seen in cases of terminal cellular differentiation and during cellular deposition of extracellular matrix molecules. A malfunction of this process may be involved in pathologies associated either with the deficiency of a protein normally produced by this mechanism or with the abnormal abundanceof a protein or of its C-terminal fragment. It seems to be responsible for some types of familial thalassemia and may underlie the overproduction of beta amyloid in sporadic Alzheimer’s disease. The aim of the present article is to systematize the current knowledge and understanding of this pathway. The outlined framework introduces unexpected features of the mRNA amplification such as its ability to generate polypeptides non-contiguously encoded in the genome, its second Tier, a physiologically occurring intracellular polymerase chain reaction, iPCR, a Two-Tier Paradox and RNA Dark Matter. RNA-dependent mRNA amplification represents a new mode of genomic protein-encoding information transfer in mammalian cells. Its potential physiological impact is substantial, it appears relevant to multiple pathologies and its understanding opens new venues of therapeutic interference, it suggests powerful novel bioengineering approaches and its further rigorous investigations are highly warranted.

Preprint ARTICLE | doi:10.20944/preprints202105.0322.v1

Replication-Dependent Biogenesis of Turnip Crinkle Virus Long Noncoding RNAs

Shaoyan Zhang, Rong Sun, Limin Zheng, Feng Qu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Virus; plant virus; long noncoding RNA; replication; positive sense RNA virus

Online: 14 May 2021 (11:01:56 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202002.0424.v1

Insufficient Sensitivity of RNA Dependent RNA Polymerase Gene of SARS-CoV-2 Viral Genome as Confirmatory Test using Korean COVID-19 Cases

Soyoun Kim, Dong-Min Kim, Baeckseung Lee

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV-2; Korean COVID-19; Wuhan Corona virus; real time PCR Ct Value; Sensitivity; False Negative

Online: 28 February 2020 (12:03:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202303.0188.v1

Immediate Effects of Quadriceps Muscle Kinesiology Taping on Joint Position Sense and Force Sense in Healthy Individuals

Mariam Maqsood, Márk Váczi

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: kinesiology tape; maximum isometric voluntary contraction; joint position sense; force sense; proprioception

Online: 10 March 2023 (08:50:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1024.v1

Tourism Development through the Sense of UNESCO World Heritage: The Case of Hegra, Saudi Arabia

Sara Sampieri, Abdellah Saoualih, Larbi Safaa, Fernando Martínez de Carnero Calzada, Marco Ramazzotti, Agustín Martínez-Peláez

Subject: Arts And Humanities, Archaeology Keywords: Sense of place, archaeological heritage sites, UNESCO world heritage sites, VADER-based sen-timent analysis, Non-negative Matrix Factorization, Hegra, TripAdvisor, Saudi Arabia.

Online: 18 March 2024 (10:38:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0181.v2

Metamaterials Demonstrating Negative Thermal Capacity

Edward Bormashenko, Evgeny Shulzinger

Subject: Chemistry And Materials Science, Biomaterials Keywords: metamaterials; negative effective mass; negative density; negative thermal capacity; resonance.

Online: 26 January 2021 (11:36:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0293.v2

Dethroning the Planetary Perspective: Dealing with Actually-Occurring Transformations Using Dialogical Sense-Making and Critical Phenomenology

Stephen Woroniecki, Victoria Wibeck, Kristin Zeiler, Björn-Ola Linnér

Subject: Arts And Humanities, Philosophy Keywords: sense making analysis; critical phenomenology; sustainability transformations

Online: 13 October 2022 (09:26:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0357.v1

Negative Electrical Conductivity Metamaterials

Edward Bormashenko

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: metamaterial; negative electrical conductivity; negative mass; Drude-Lorentz model; negative refraction

Online: 28 March 2022 (08:56:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0110.v1

The Link between ADHD and Antisocial Behavior: The Moderating Role of the Protective Factor Sense of Coherence

Haym Dayan, Mona Khoury-Kassabri, Yehuda Pollak

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Antisocial Behavior; Sense of Coherence; Protective Factors

Online: 7 September 2022 (11:03:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0167.v1

Sense of Safety and Planning and Design Policies

Rangajeewa Ratnayake, Naduni Wickramaarachchi, Julie Rudner

Subject: Social Sciences, Safety Research Keywords: CBD; planning and design policies; sense of safety

Online: 26 February 2018 (12:07:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1216.v1

Exploration of the Feeling Sensing Analysis via Electrochemical In-Vitro Carbon Nano Tube Paste Tattoo Working Sensor

Jong wan Choi, Ji won Min, Sahng wook Kim, Jung Hyun Park, Suw Young Ly5

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Voltammetry, bio current, feeling sense, in vivo, brain wave

Online: 16 August 2023 (13:48:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0749.v1

The Mediating Role of Psychological Distress in Excessive Gambling Among Young People: A Four-Country Study

Ilkka Vuorinen, Atte Oksanen, Iina Savolainen, Anu Sirola, Markus Kaakinen, Hye-Jin Paek, Izabela Zych

Subject: Social Sciences, Psychology Keywords: psychological distress; loneliness; sense of mastery; adolescents; young adults

Online: 31 May 2021 (11:35:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0281.v1

Belonging, Strangerhood and Mobility: South Sudanese in a Rural Town, Victoria

Naduni Wickramaarachchi, Edgar Burns

Subject: Arts And Humanities, Humanities Keywords: migrants; sense of belonging; small town; stranger; South Sudanese

Online: 30 January 2018 (10:35:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1899.v1

Impact of Peripheral Magnetic Stimulation on Sensory Ataxic Paresis of Upper Extremity Early after Stroke: A Pilot Randomized Controlled Trial

Shigeru Obayashi, Rina Takahashi, Hirotaka Saito, Kazue Taguchi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: motor recovery; neurorehabilitation; proprioceptive impairment; position sense; thumb localizing test

Online: 30 October 2023 (10:32:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0602.v1

On the Inconsistency of: The Classical Propositional Calculus and Its Metatheory

Lukasz Stepien

Subject: Computer Science And Mathematics, Logic Keywords: classical propositional calculus; zero-order logic; zeroth-order logic; consistency in the traditional sense; consistency in the absolute sense; inconsistency; metalogic; metatheory

Online: 8 December 2023 (10:31:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0387.v1

Mass or Energy? On Charge of Gravity

Zhong-Yue Wang

Subject: Physical Sciences, Mathematical Physics Keywords: universal gravitation; negative energy; repulsion; negative mass; MOND (Modified Newtonian Dynamics)

Online: 26 March 2020 (14:03:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1895.v1

Bounded Number Theory: A Study on the Negation of Infinite Numbers in Parts or Completely

carlos eduardo ramos cardoso cardoso

Subject: Computer Science And Mathematics, Mathematics Keywords: limited number; different physical spaces; mathematics sense; number belongs to space

Online: 30 October 2023 (10:11:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1736.v1

The Influence of Urban Gardening Activities on Participants’ Perceived Restorativeness, Resilience, Sense of Community and Stress

Hee-Ran Kim, Won-Suk Oh, Jin Gun Kim, Won Sop Shin

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Urban Garden; Perceived Restorativeness; Resillience; Sense of Community; Stress; Salivary cortisol

Online: 25 May 2023 (05:10:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201911.0386.v1

How a Strategic Scoping Canvas Can Facilitate Collaboration between Partners in Sustainability Transitions

Seerp Wigboldus, Jan Brouwers, Herman Snel

Subject: Social Sciences, Area Studies Keywords: multi-stakeholder processes; sustainability transformations; sense-making; strategy; theory of change

Online: 30 November 2019 (09:52:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0282.v1

Ascertaining the Sense of Safety in Urban Neighborhood Streets: The Case of Kotahena, Sri Lanka

Sanduni Karunananda, Amanda Rajapakse, Rangajeewa Rathnayake

Subject: Social Sciences, Safety Research Keywords: environmental cues; fear of crime spots; sense of safety; social cues

Online: 1 February 2018 (07:59:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0255.v1

Exact Solutions for a Novel H₂ Optimal Design of Electromagnetic Tuned Mass Damper

Ge Li, Qibo Mao, Yifan Luo, Yong Wang, Lei Liu

Subject: Engineering, Mechanical Engineering Keywords: electromagnetic tuned mass damper; H2 optimization; structural vibration control; negative inductance; negative resistance.

Online: 18 October 2021 (15:37:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0053.v1

Theory of Relationships between Spaces to Obtain Numerical Knowledge

carlos eduardo ramos cardoso cardoso

Subject: Computer Science And Mathematics, Mathematics Keywords: relationships between spaces; numerical knowledge; sense of mathematics; odd and even numbers

Online: 1 November 2023 (09:46:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0981.v1

Sarcosine May Induce EGF Production or Inhibit the Decline in EGF Concentrations in Patients with Chronic Schizophrenia (Results of the PULSAR Study)

Agnieszka Pawlak, Bartosz Kaczmarek, Adam Wysokiński, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: EGF; sarcosine; schizophrenia; negative symptoms

Online: 14 August 2023 (04:47:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0315.v1

Modeling Traffic Accident Occurrence at Hazardous Road Locations: A Case Study in Tunisia

Fedy Ouni, Mounir Belloumi

Subject: Business, Economics And Management, Economics Keywords: Crash counts; Hazardous Road Locations; Pearson correlation; Random effect negative binomial; Negative binomial model

Online: 13 November 2018 (13:02:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0104.v1

Internalization of Negative External Cost of Logistics and Incentive Mechanism

Zhanzhong Wang, Zhouling Tsai, Jing Fu, Guangdong Tian

Subject: Engineering, Control And Systems Engineering Keywords: green logistics; negative externality of logistics; internalization of logistics negative external cost; incentive mechanism

Online: 20 December 2016 (10:37:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1056.v1

Flood Perception from Local Perspective of Rural Community vs Geomorphological Control of Fluvial Processes in Large Alluvial Valley (the Middle Vistula River, Poland)

Daria Wiesława Krasiewicz, Grzegorz Wierzbicki

Subject: Environmental And Earth Sciences, Geography Keywords: sense of place; dyke; flood protection embankment; flood collective memory; suballuvial bedrock protrussion

Online: 15 August 2023 (08:42:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0790.v1

Does the High Level of Navigational Strategy Depend On the Number of Flight Hours or on an Innate Predisposition? The Case of Military Pilots

Marco Giancola, Paola Verde, Luigi Cacciapuoti, Gregorio Angelino, Laura Piccardi, Alessia Bocchi, Massimiliano Palmiero, and Raffaella Nori

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Cognitive style; Spatial Cognition; Sense of Direction; Spatial Orientation; Mental Rotation; Individual Differences

Online: 30 April 2021 (15:23:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0263.v9

Novel Recurrence Relations for Volumes and Surfaces of N-Balls, Regular N-Simplices, and N-Orthoplices in Real Dimensions

Szymon Łukaszyk

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular convex polytopes; negative dimensions; fractal dimensions

Online: 8 June 2022 (12:29:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0217.v1

Aptamer Bead-Mediated Separation of Gram-Negative Bacteria Using Acoustophoresis

Sang Woo Lee, Byungw Woo Kim, Hye-Su Shin, Anna Go, Minho Lee, Dong-ki Lee, Soyoun Kim, Ok Chan Jeong

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aptamer: acoustophoresis; microfluidics; gram-negative bacteria

Online: 18 October 2019 (11:41:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0230.v1

Refusal Parenting Style Is Easier for Students to Perceive Non-physical Bullying in the Upper Grades of Elementary School: Mediation Effect of Negative Affect Experience and Negative Coping Style

Houyu Zhou, Qinfei Wang, Shuxu Yu, Quangquang Zheng

Subject: Social Sciences, Psychology Keywords: perceiving campus non-physical bullying; Refusal parenting style; negative affect experiences; negative coping style; mediating effect

Online: 17 January 2022 (14:09:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1704.v1

Fruitlet Freeze Tolerance in Peach Germplasm

Ufuk Caglar, John Mark Lawton, Juan Carlos Melgar, Ksenija Gasic

Subject: Biology And Life Sciences, Horticulture Keywords: broad sense heritability; climate change; cold stress; electrolyte leakage; late spring frosts; Prunus persica.

Online: 22 December 2023 (04:56:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0054.v1

Early and Dynamic Socio-Academic Variables Related to Dropout Intention: A Predictive Model Made During Pandemic

Jorge Maluenda-Albornoz, Valeria Infante-Villagrán, Celia Galve-González, Gabriela Flores-Oyarzo, José Berríos-Riquelme

Subject: Social Sciences, Education Keywords: dropout intention; perceived social isolation; perceived social support; engagement; sense of belonging; higher education

Online: 3 December 2021 (13:08:34 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202103.0466.v1

The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

Valentina Pacella, Giuseppe Kenneth Ricciardi, Silvia Bonadiman, Elisabetta Verzini, Federica Faraoni, Michele Scandola, Valentina Moro

Subject: Social Sciences, Psychology Keywords: anarchic hand syndrome; DTI; white matter disconnection; lesion mapping; sense of agency; posterior lesions.

Online: 18 March 2021 (10:09:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0288.v1

COVID-19 and Health Information Seeking Behavior: Digital Health Literacy Survey Amongst University Students in Pakistan

Rubeena Zakar, Sarosh Iqbal, Muhammad Zakria Zakar, Florian Fischer

Subject: Business, Economics And Management, Accounting And Taxation Keywords: eHealth Literacy; digital health literacy; sense of coherence; COVID-19; COVID-HL-Q; Pakistan.

Online: 10 March 2021 (15:07:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1525.v1

The Eﬀects of Idol Fans’ Interactions in Online Fan Community Platforms on Their Well-Being and Loyalty

Soyoung Wang, Min Sung Kim, Seongcheol Kim

Subject: Social Sciences, Media Studies Keywords: Fan community platform; Mental well-being; Sense of virtual community; Fan interaction; Parasocial relationship; Weverse

Online: 22 August 2023 (07:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1625.v1

Triple Negative Breast Cancer Subclassified by Immunohistochemistry: Correlation with Clinical and Pathological Outcomes in Patients Receiving Neoadjuvant Chemotherapy

Bruno de Paula, Susanne Crocamo, Carlos Sousa, Priscila Valverde Fernandes, Fabiana Rezende, Eliana Abdelhay

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: triple negative breast cancer; immunohistochemistry; neoadjuvant chemotherapy

Online: 24 April 2024 (15:29:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0301.v1

Immunological Response against Breast Lineage Cells Transfected with Human Papillomavirus (HPV)

Daffany Luana dos Santos, Bianca de França São Marcos, Georon Ferreira De Sousa, Leonardo Carvalho de Oliveira Cruz, Bárbara Rafaela da Silva Barros, Mariane Cajuba de Britto Lira Nogueira, Talita Helena de Araújo Oliveira, Anna Jéssica Duarte Silva, Vanessa Emanuelle Pereira Santos, Cristiane Moutinho Lagos De Melo, Antonio Carlos De Freitas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keywords: oncogenes; MDA-MB-231; triple-negative.

Online: 4 January 2024 (03:06:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1702.v1

BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model

Seong Min Kim, Seung Hyuck Jeon, Min Guk Han, Mi Hyun Kang, In Ah Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: BRD4; radiation therapy; triple-negative breast cancer

Online: 26 July 2023 (10:08:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0112.v1

Auxetic Structures from Rotating Squares

Julian Plewa, Małgorzata Płońska, Paweł Lis

Subject: Engineering, Mechanical Engineering Keywords: auxetic structures; metamaterials; negative Poisson’s ratio (NPR)

Online: 8 February 2022 (13:15:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0174.v1

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women

Tarun Mamidi, Jiande Wu, Paul B. Tchounwou, Lucio Miele, Chindo Hicks

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: gene expression obesity triple negative breast cancer

Online: 20 March 2018 (07:56:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0486.v1

The Modified Fundamental Equations of Quantum Mechanics in Symmetric Forms

Huai-Yu Wang

Subject: Physical Sciences, Quantum Science And Technology Keywords: Dirac equation; Klein-Gordon equation; Schrödinger equation; negative kinetic energy; Decoupled Klein-Gordon equation; negative kinetic energy Schrödinger equation

Online: 25 August 2021 (10:50:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0368.v1

The Role of Perceived Social Support in the Psychological Well-Being of Young Offenders: from Pretrial Detention to Correctional Camps

Fedor Ushkov, Roman Shilko, Ludmila Shaigerova, Alexandra Dolgikh, Olga Almazova, Olga Vakhantseva, Yuri Zinchenko

Subject: Social Sciences, Psychology Keywords: psychological well-being; young offenders; social support; pretrial detention; correctional camps; positive and negative feelings; positive and negative affects

Online: 29 November 2019 (04:16:05 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202404.0655.v3

Systematically Disproving Two Widely Accepted Notions Regarding Entropy

Ji-Ming Chen, Ji-Wang Chen

Subject: Thermodynamics, Physical Sciences Keywords: disorder; energy; entropy; life, negative entropy, probability, thermodynamics

Online: 26 April 2024 (07:54:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1073.v1

The Effect of Ambient Illumination and Text Color on Visual Fatigue Under Negative Polarity

Qiangqiang Fan, Jinhan Xie, Yang Wang, Zhaoyang Dong

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: visual fatigue; ambient illumination; Negative polarity; text color

Online: 17 April 2024 (11:26:44 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0899.v1

A Study on the Factors for the Occurrence of Vacant Homes in Medium Cities and Characteristics of Each Types – Focusing on Asan City, Chungcheongnam-Do

Jeonghyeon Choi, Seung-Seok Han, Myung-je Woo

Subject: Social Sciences, Urban Studies And Planning Keywords: vacant home; poisson; negative binomial regression; spatial regression

Online: 15 March 2024 (07:48:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0676.v1

The First Two Years of COVID-19 Hospitalization Characteristics and Costs: Results from the National Discharge Registry

Pierpaolo Ferrante

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; incidence; lethality; negative binomial; moving averages

Online: 12 March 2024 (08:20:48 CET)

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ABSTRACT Background: To date, the COVID-19 pandemic has been the foremost health concern for humankind in the new millennia. This paper aims to describe the related hospitalizations in Italy during the first two years of the health emergency. Design and methods: This is a retrospective, population-based study of Italian hospitalizations for patients diagnosed with COVID-19 during the 2020-2021 period, extracted from the National Hospital Discharge Registry. The outcome variables considered include hospital admissions, costs, and length of stay, among other hospitalization-level variables. Costs were estimated through the charges associated with the Diagnosis-Related Group and Major Diagnostic Categories coding system, plus an additional cost attributed to COVID-19 admissions. To these charges was added an extra cost defined by the ministry of health. Results: In Italy, there were 357,354 hospitalizations for COVID-19 attributed to 298,856 patients in 2020 and 399,043 hospitalizations for COVID-19 attributed to 333,447 patients in 2021. COVID-19 patients faced a transfer rate thrice that of other patients. Hospitalizations were concentrated predominantly in the northern regions, particularly in the first year. Hospitalization rates varied by age in a sine wave pattern, peaking in the youngest and oldest age groups, with mortality rates escalating with age— tending to remain below 3% for those under 44 but surging to 40% in individuals over 75. The financial impact of COVID-19 hospitalizations was substantial, with total costs reaching €3.97 billion in 2020 and €4.99 billion in 2021. Costs per admission and per day also rose, from €11,112 and €807 in 2020 to €12,503 and €844 in 2021, respectively. Excluding the added financial burden of COVID-19, costs would have been notably lower. Hospitalizations involving continuous invasive mechanical ventilation were particularly costly (about 24.000 euros x admission), reflecting the significant resources required for these treatments. Conclusion: Implementing a protective pad around the entire health system that leverages networks of family doctors and nurses, connected in real time to the entire health system, can be crucial. Such a network, tasked with monitoring the local epidemiological situation, protecting vulnerable individuals also through telehealth visits, and establishing a triage system for infections in the initial phase, may effectively help in managing virus spread and protecting hospitals from unpredictable waves of admission demand. Strengthening primary health care could be a decisive factor for the future and enhance the system's resilience in facing new challenges.

Preprint ARTICLE | doi:10.20944/preprints202401.1741.v1

The Possible Bulk Superconductivity in Bi Doped BaFe₂As₂ Single Crystals

Jiabin Si, Jianfa Zhao, Ying Liu, Ying Liu, Changqing Jin, Jibing Liu, Lingyi Xing

Subject: Physical Sciences, Condensed Matter Physics Keywords: BaFe2As2; iron-based superconductor; isovalent doping; negative pressure

Online: 24 January 2024 (08:10:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1769.v1

Neonatal Bloodstream Infection with Ceftazidime-Avibactam-Resistant KPC-2 Producing- Klebsiella pneumoniae Carrying the VEB-25 Gene

Charalampos Zarras, Elias Iosifidis, Maria Simitsopoulou, Styliani Pappa, Angeliki Kontou, Emmanuel Roilides, Anna Papa

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Multi-drug resistance; Gram-negative bacteria; Enterobacterales; carbapenemases

Online: 26 June 2023 (09:40:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0074.v1

Triple Negative Breast Cancer Treatment Options and Limitations: Future Outlook

Onyinyechi Obidiro, Gantumur Battogtokh, Emmanuel O. Akala

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple negative breast cancer; chemotherapy; immunotherapy; limitations; nanotechnology

Online: 1 June 2023 (08:58:25 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201912.0170.v1

Necrotic Skin Infection by Sphingomonas Paucimobilis in Amazonia Region

Talles Henrique Pichinelli Maffei, Frederico Alberto Bussolaro, Arlei Belaus, Alexandra Prevedello, Claudine Thereza-Bussolaro

Subject: Medicine And Pharmacology, Dermatology Keywords: sphingomonas; gram-negative bacterial infection; skin disease; bacterial

Online: 12 December 2019 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0877.v1

A Challenge in A(G)I, Cybernetics Revived in the Ouroboros Model as One Algorithm for All Thinking

Knud Thomsen

Subject: Physical Sciences, Other Keywords: Ouroboros Model; Analogical Algorithms; AI-Challenge; Large Language Models; Cybernetics; Synergetics; Understanding; Common Sense; Consciousness; Free Will.

Online: 13 July 2023 (12:28:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1138.v1

Overall Survival and Prognostic Factors in Metastatic Triple-Negative Breast Cancer: an NCDB Analysis

Meghana Kesireddy, Lina Elsayed, Valerie K Shostrom, Priyal Agarwal, Samia Asif, Amulya Yellala, Jairam Krishnamurthy

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: metastatic triple negative breast cancer; overall survival; prognostic factors

Online: 17 April 2024 (12:01:26 CEST)

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Background: Metastatic triple-negative breast cancer (TNBC) is aggressive with a poor median overall survival (OS), ranging from 8 to 13 months. There exists considerable heterogeneity in the survival at the individual patient level. To better understand the survival heterogeneity and improve risk stratification, our study aims to identify the factors influencing survival utilizing a large patient sample in the National Cancer Database (NCDB). Methods: Women diagnosed with metastatic TNBC from 2010 to 2020 in the NCDB were included. Demographic, clinic-pathological, treatment data, and overall survival (OS) outcomes were collected. Kaplan-Meier curves were used to estimate OS. The log-rank test was used to identify OS differences between groups for each variable in the univariate analysis. For the multivariate analysis, the Cox proportional hazard model with backward elimination was used to identify factors affecting OS. Adjusted hazard ratios and 95% confidence intervals are presented. Results: 2,273 women had a median overall survival of 13.6 months. Factors associated with statistically significantly worse OS included older age, higher comorbidity scores, specific histologies, higher number of metastatic sites, presence of liver or other site metastases in those with only one metastatic site (excluding brain metastases), presence of cranial and extra-cranial metastases, lack of chemotherapy, lack of immunotherapy, lack of surgery to distant sites, lack of radiation to distant sites, and receipt of palliative treatment to alleviate symptoms. In the multivariate analysis, comorbidity score, histology, number of metastatic sites, immunotherapy, and chemotherapy had a statistically significant effect on the OS. Conclusions: Through NCDB analysis, we have identified prognostic factors for metastatic TNBC. These findings will help improve prognostication at diagnosis, optimize treatment strategies, and facilitate patient stratification in future clinical trials.

Preprint ARTICLE | doi:10.20944/preprints202404.0560.v1

Questions and Answers in the Negative Footprint Illusion Paradigm: A Reply to Gorissen et al. (2024)

Patrik Sörqvist, John E. Marsh

Subject: Social Sciences, Psychology Keywords: negative footprint illusion; judgment; environmental impact; bias; attribute substitution

Online: 8 April 2024 (15:39:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0415.v1

Discovery of Two Targets of Dexmedetomidine in Breast Cancer

Jie Luo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple-negative breast cancer; dexmedetomidine; IDO1; CHRM3

Online: 7 February 2024 (08:18:40 CET)

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Background: As the most invasive breast cancer (BrCa), triple-negative BrCa (TNBC) has the worst survival. The use of dexmedetomidine potentially affected BrCa surgery and dexmedetomidine was reported to have direct effects on TNBC cells. The objective of this study is to explore the mechanisms underlying the effect of dexmedetomidine on TNBC. Methods: Dexmedetomidine targets were predicted using The Cancer Genome Atlas data SwissTargetPrediction. Cell lines MDA-MB-231, MCF7, and MCF10A were used to validate the targets in TNBC with both clinical samples and cell lines. Cancer cell lines and normal breast cell lines were grouped in cancer and normal groups respectively. Both groups were exposed to dexmedetomidine treatment. Cell Counting Kit-8 was used to determine the effect of dexmedetomidine on cells with target silencing. The binding model of the candidate targets was docked and critical amino acids were mutated to validate the binding model. Results: Dexmedetomidine selectively inhibits cancer cells. Catalytic subunit of the DNA-dependent protein kinase (PRKDC), indoleamine 2,3-dioxygenase 1 (IDO1), opioid receptor kappa 1 (OPRK1), glutaminyl-peptide cyclotransferase (QPCT), macrophage migration inhibitory factor (MIF), potassium voltage-gated channel, subfamily H (Eag-related), member 2 (KCNH2), cholinergic receptor, muscarinic 3 (CHRM3), and potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4) were identified as dexmedetomidine targets in TNBC. The expression levels of PRKDC, IDO1, MIF, KCNH2, CHRM3, and KCNN4 were found to be upregulated in TNBC tissues compared to non-TNBC tissues(p<0.05). Silencing of these genes was found to reduce the sensitivity of TNBC cells to dexmedetomidine(p<0.05). This effect was counteracted when the silenced genes were overexpressed, resulting in an increase in the sensitivity of cells to dexmedetomidine (p<0.05). Furthermore, a direct interaction between dexmedetomidine and IDO1 and CHRM3 was observed, which regulated the sensitivity of cells to dexmedetomidine(p<0.05).Conclusion: IDO1 and CHRM3 are direct targets of dexmedetomidine in TNBC.

Preprint ARTICLE | doi:10.20944/preprints202307.0405.v1

Selection of A New Biasing Parameter for the Jackknife Kibria-Lukman Estimator for the Negative Binomial Regression Model

Oranye Henrietta E, Adejuwon Samuel O, Arum Kingsley C, Ugwuowo Fidelis I, Ugah Tobias E, Adegoke Taiwo M, Sule Omeiza B

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Jackknife; Kibria-Lukman; estimator; Maximum Likelihood; Negative Binomial regression

Online: 6 July 2023 (08:58:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1575.v1

Application of Heisenberg’s Uncertainty Principle in the Diag-Nostic Dilemma of Children With Acute Appendicitis: Negative Appendectomy Versus Complicated Appendicitis Rates

Stylianos Roupakias, Sotirios Fouzas, Eirini Kostopoulou, Despoina Gkentzi, Theodore Dassios, Ioannis Spyridakis, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Surgery Keywords: complicated appendicitis; negative appendectomy; Heisenberg’s principle; diagnostic uncertainty; children

Online: 23 May 2023 (04:58:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0146.v1

Revolutionizing Prosthetic Design with Auxetic Metamaterials: A Review of Mechanical Properties and Limitations

Muhammad Faris Fardan, Bhre Wangsa Lenggana, U Ubaidillah, Seung-Bok Choi, Didik Djoko Susilo, Sohaib Z. Khan

Subject: Engineering, Mechanical Engineering Keywords: prosthetic devices; metamaterials; auxetic structure; negative Poisson’s ratio; metastructure

Online: 3 May 2023 (12:31:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0026.v1

Dark Energy is Dark Matter below Absolute Zero in Black Holes

Roumen Tsekov

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Neutrino, Dark Matter, Dark Energy, Black Holes, Negative Temperature

Online: 2 February 2022 (09:35:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0195.v1

Comparative Study of Computational Models for Reducing Air Pollution Through the Generation of Negative Ions

Paola Ortiz-Grisales, Julián Patiño-Murillo, Eduardo Duque-Grisales

Subject: Engineering, Automotive Engineering Keywords: Environmental pollution; air purification; negative ion generators; particulate matter.

Online: 10 May 2021 (14:02:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0782.v2

A Review of Electrospun Carbon Nanofiber-Based Negative Electrode Materials for Supercapacitors

Arjun Prasad Tiwari, Tanka Mukhiya, Alagan Muthurasu, Kisan Chhetri, Minju Lee, Bipeen Dahal, Prakash Chandra Lohani, Hak Yong Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: electrospinning; negative electrode materials; carbon nanofibers; free-standing; supercapacitor

Online: 10 May 2021 (09:34:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0078.v1

How Would Different Types of Negative Life Events Predict Adolescents’ Suicidal Ideation ? - an Empirical Study Based on the Western Region of China

Moye Xin, Xueyan Yang, Kun Liu

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Negative life events; Suicidal ideation; Suicidalogy; Adolescents; Gender difference

Online: 4 March 2021 (15:56:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0517.v1

Metabolite Transporter and Its Impact on Metabolic Engineering Approaches

Mostafa Gomaa FADL

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gram-negative bacterial; Metabolite transporter; pathways; metabolic engineering approaches

Online: 25 January 2021 (15:49:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0076.v6

Unification of the Electromagnetic Force and Gravity through the Composite Photon

Ian Clague

Subject: Physical Sciences, Acoustics Keywords: Unification; Composite Photon; Negative Mass; Antimatter; Grand Unification Theory, Dark Energy, Dark Matter

Online: 28 October 2021 (10:06:39 CEST)

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Working Paper ARTICLE

Inhibition of DNA Repair Pathways and Induction of ROS are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

Suzanne Bakewell, Isabel Conde, Yassi Fallah, Mathew McCoy, Lu Jin, Ayesha Shajahan-Haq

Subject: Biology And Life Sciences, Aging Keywords: breast cancer; BOLD-100; olaparib; triple negative breast cancer

Online: 22 July 2020 (10:00:52 CEST)

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Working Paper ARTICLE

On the Theory and Design of Cold Resistors

Jiaao Song, Laszlo B. Kish

Subject: Engineering, Electrical And Electronic Engineering Keywords: thermal noise; negative feedback; low-noise resistors; theory; design

Online: 31 May 2020 (19:02:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0418.v1

Negative Effective Mass in Plasmonic Systems

Edward Bormashenko, Irina Legchenkova

Subject: Physical Sciences, Condensed Matter Physics Keywords: metamaterials; negative effective mass; plasma oscillations; low frequency plasmons

Online: 29 March 2020 (03:39:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0438.v1

Adiabatic Thermodyhamics

Christian Fronsdal

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: entropy; thermodynamics; conservative hydrodynamics; rotations; meniscus; planets; negative pressure

Online: 19 November 2018 (09:42:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201706.0059.v1

Pathology of Adult and Paediatric Mitochondrial Myopathies

Rahul Phadke

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: mitochondrial; muscle biopsy; ragged red; COX-negative; subsarcolemmal; immunohistochemistry

Online: 13 June 2017 (06:23:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0176.v1

The Severity of Traumatic Stress Associated with COVID-19 Pandemic, Perception of Support, Sense of Security, and Sense of Meaning in Life Among Nurses: Research Protocol and Preliminary Results from Poland

Grzegorz Józef Nowicki, Barbara Ślusarska, Kinga Tucholska, Katarzyna Naylor, Agnieszka Chrzan-Rodak, Barbara Niedorys

Subject: Public Health And Healthcare, Nursing Keywords: COVID-19; nurses; posttraumatic stress disorder; perceived social support; changes in outlook; sense of security; meaning in life

Online: 7 August 2020 (08:10:28 CEST)

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The COVID-19 pandemic affects not only physical health but also deteriorates mental health resulting in sleep problems, depression, and traumatic stress. Our research investigates the level of posttraumatic stress, perceived social support, opinions on positive and negative consequences of the pandemic, sense of security, and sense of meaning among nurses in the face of new and not fully understood global epidemiological phenomena. For this purpose, computer-assisted web interviewing methods were conducted between May 1 and May 15, 2020. Participating nurses completed the following research tools: The Impact Event Scale-Revised (IES-R), The Multidimensional Scale of Perceived Social Support (MSPSS), The Changes in Outlook Questionnaire (CIOQ), The Safety Experience Questionnaire (SEQ) and The Meaning in Life Questionnaire (MLQ). Three hundred and twenty-five nurses working throughout Poland joined the study of an average age of 39.18 ± 11.16 years. The average overall IES-R score in the study group was 1.78 ± 0.65. Among the dimensions of traumatic stress, the highest score was obtained in the dimension Avoidance 1.86 ± 0.73, then in the dimensions Hyperarousal 1.8 ± 0.78 and Intrusion 1.74 ± 0.83. Amongst studied nurses, the highest support rates were provided by significant others (22.58 ± 5.22), then from friends (21.91 ± 5) and family (21.45 ± 4.4). Among the surveyed nurses, higher average scores were noted in the subscale measuring positive psychological changes (18.56 ± 4.04). In contrast, a higher average level of assessment was noted on the Reflection on the safety dimension (4.21 ± 0.49). The mean MLQ score was 5.33 ± 0.87. A slightly higher result was observed in the subscale Presence (5.35 ± 1.14). The results of the research implemented during the period of severe psychological pressure associated with the COVID-19 pandemic provided information on symptoms of traumatic stress in the examined group of nurses. Their sense of security has been lowered and accompanied by an intensified reflection on issues concerning security. However, the sense of meaning (currently felt) in life remains higher than the tendency to searching for it. The surveyed nurses perceive individual support from the so-called significant others (apart from family and friends). They see positive changes resulting from painful experiences related to the COVID-19 pandemic, which can be characterized by adaptation in the form of posttraumatic growth.

Preprint ARTICLE | doi:10.20944/preprints202402.1001.v4

ISM: A New Space-Learning Model for Heterogenous Multi-view Data Reduction, Visualization and Clustering

Paul Fogel, Galina Boldina, Franck Augé, Christophe Geissler, George Luta

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Principal Component Analysis; Non-negative Matrix Factorization; Non-negative Tensor Factorization; Multi-view Clustering; Canonical Correlation Analysis; Common Principal Components; Multi Dimensional Scaling

Online: 18 April 2024 (02:44:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1445.v1

Increased PIEZO1 expression is associated with worse clinical outcomes in hormone receptor negative breast cancer patients

Rylee Ann Poole, Qingfei Wang, Alo Ray, Kazuaki Takabe, Mateusz Opyrchal, Eriko Katsuta

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ion channels; hormone receptor negative breast cancer; PIEZO; mechano-signaling

Online: 19 December 2023 (11:32:33 CET)

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PIEZO1 plays a crucial role in the human body as a mechanosensory ion channel. It has been demonstrated that PIEZO1 is important in tissue development and regulating many essential physiological processes. Studies have suggested that the PIEZO1 ion channel plays a role in invasion and progression in cancer; elevated levels of PIEZO1 have been correlated with increased migration in breast cancer cells, chemo-resistance and invasion in gastric cancer cells, and increased invasion of osteosarcoma cells. In addition, high PIEZO1 expression levels were correlated with a worse prognosis in glioma patients. On the other hand, studies in lung cancer have attributed high PIEZO1 levels to better patient outcomes. However, the clinical impact of PIEZO1 in breast cancer is not well characterized. Therefore, our goal was to determine the clinical relevance of PIEZO1 in breast cancer. Analysis of breast cancer data from The Cancer Genome Atlas (TCGA) was conducted to investigate PIEZO1 expression levels and correlation to survival, followed by validation in an independent dataset, GSE3494. We also performed gene set enrichment analysis (GSEA) and analyzed immune cell levels in breast tumors from TCGA through a CIBERSORT algorithm. Our results demonstrated that PIEZO1 expression levels are higher in hormone receptor (HR) negative than HR positive cohorts. High PIEZO1 expression is correlated with a significant decrease in survival in HR negative cohorts, suggesting that PIEZO1 could be utilized as a prognostic biomarker in HR negative breast cancer. GSEA showed that various signaling pathways associated with more invasive phenotypes and resistance to treatments, including epithelial-mesenchymal transition (EMT), hypoxia, and multiple signaling pathways, are enriched in high PIEZO1 HR negative tumors. Our results also demonstrated a decrease in CD8+ and CD4+ T cell infiltration in high PIEZO1 HR negative tumors. Further investigations are necessary to elucidate the mechanistic roles of PIEZO1 in HR negative breast cancer.

Preprint COMMUNICATION | doi:10.20944/preprints202312.1034.v1

Phenotypic and Genotypic Assays to Evaluate Coagulase-Negative Staphylococci Biofilm Production in Bloodstream Infections

Giulia Grassia, Jessica Bagnarino, Mariangela Siciliano, Daniela Barbarini, Marta Corbella, Patrizia Cambieri, Fausto Baldanti, Vincenzina Monzillo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: biofilm; bloodstream infection; catheter; coagulase-negative staphylococci (CoNS); S. epidermidis

Online: 14 December 2023 (10:06:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0655.v1

Negative Thermal Quenching of Photoluminescence- an Evaluation from Macroscopic Viewpoint

Shirun Yan

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Reliability assessment; Negative thermal quenching; Consistency of the measurement condition.

Online: 11 December 2023 (06:15:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0515.v1

Shared E-scooter Practices in Birmingham, Alabama: Analyzing Usage, Patterns, and Determinants

Mithila Hasan, Virginia P. Sisiopiku

Subject: Engineering, Civil Engineering Keywords: shared micromobility; e-scooters; spatiotemporal analysis; negative binomial regression analysis

Online: 8 November 2023 (04:46:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1088.v1

Fetuin-A Modulates Tumor Growth and Invasion in a Basal-Like Triple Negative Breast Cancer Cell Line, MDA-MB-468

Divya Kenchappa, Olga Y Korolkova, Peace Odiase, Michael G. Izban, Amos Sakwe, Josiah Ochieng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Fetuin-A; Triple Negative; Breast Cancer; TLR4; Invasion; Basal-like

Online: 15 September 2023 (16:02:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0283.v1

The Relationship between the Family Environment and Disordered Eating Patterns: A Moderated Mediated Model of Automatic Thoughts and Gender

Badra Hamdi Alghanami, Mogeda El Sayed El Keshky

Subject: Social Sciences, Psychology Keywords: family environment; eating disorders; negative thoughts; mediation analysis; Saudi Arabia

Online: 5 July 2023 (10:40:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0268.v1

Identification of Influential Features for User Engagement with Wellness Content: Analysis of nyt_well Instagram Account

Seungjun Kim

Subject: Public Health And Healthcare, Other Keywords: wellness; health; user engagement; social media; instagram; negative binomial regression

Online: 12 April 2023 (09:46:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0133.v1

Can Radiomics Provide Additional Information in [18F]FET-Negative Glioma?

Katharina Von Rohr, Marcus Unterrainer, Adrien Holzgreve, Maximilian A. Kirchner, Zhicong Li, Lena M. Unterrainer, Bogdana Suchorska, Matthias Brendel, Jörg-Christian Tonn, Peter Bartenstein, Sibylle Ziegler, Nathalie L. Albert, Lena Kaiser

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: amino acid PET; FET PET; glioma; FET negative; photopenic; radiomics

Online: 9 September 2022 (09:31:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0349.v1

Spatial Distribution of Cyclograpsus cinereus Dana 1851 in Rocky Shores of Antofagasta (23º27’ S, Chile)

Patricio De los Rios-Escalante, Carlos Esse, Marco Antonio Retamal, Oscar Zuñiga, Maritza Fajardo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Cyclograpsus cinereus; spatial distribution; intertidal; rocky shore; negative binomial distribution.

Online: 24 January 2022 (11:48:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0476.v1

Comparison of social inequality in HPV vaccination among teenagers with parental reports and healthcare providers’ records in the 2019 National Immunization Survey-Teen.

Sol Seo Choi, Bongkyoo Choi

Subject: Social Sciences, Sociology Keywords: Human Papillomavirus, vaccine, social inequality, NIS-Teen, false negative, SES.

Online: 30 December 2021 (00:14:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0614.v1

Mixed Effects and Mechanisms of Cannabinoids for Triple-Negative Breast Cancer Treatment

Khanh Tran

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Triple-negative breast cancer; cannabinoid; marijuana; cell signalling; medicinal plants

Online: 28 July 2021 (08:56:32 CEST)

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Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the lack of estrogen receptors (ER), progesterone receptors, and HER-2 receptors. Thus, TNBC tumours do not benefit from the current therapies targeting ER or HER-2. Therefore, there is an urgent need to develop novel treatment for this subtype of breast cancer. Marijuana is a common name given to Cannabis plants, a group of plants in the Cannabis genus of the Cannabaceae family. Cannabis plants are among the oldest cultivated crops, traced back at least 12,000 years and are well known for their multi-purpose usage, including medicinal purposes. The main active compounds extracted from Cannabis plants are 21-carbon-containing terpenophenolics, which are referred to as phytocannabinoids. Of these, the tetrahydrocannabinol (THC) group contains highly potent cannabinoids, including delta-9-tetrahydrocannabinol (∆9-THC) and delta-8-tetrahydrocannabinol (∆8-THC), which are the most abundant THCs and are largely responsible for psychological and physiological effects of marijuana. The use of Cannabis plants for medicinal purposes was first recorded in 2337 BC in China, where Cannabis plants were used to treat pains, rheumatism, and gout. Recently, several cannabinoids have been approved for a number of treatments, one of which is the treatment of nausea and vomiting caused by chemotherapy in cancer patients. Furthermore, increasing evidence shows that cannabinoids not only attenuate side effects due to cancer treatment, but might also potentially possess direct antitumor effects in several cancer types, including breast cancer. However, anti-tumour activity of marijuana has been variable in different studies and even promoted tumour growth in some cases. In addition, the mechanisms of cannabinoid action in cancer remain unclear. This review summarizes evidence about the mixed actions of cannabinoids in cancer in general and triple-negative breast cancer in particular.

Preprint ARTICLE | doi:10.20944/preprints202107.0238.v1

An Idea about Negative Cosmic Time in the Big Bang-Big Rip Cosmological Model

Mohamed Abdalla Bakry, Ali Eid, A. Alkaoud

Subject: Physical Sciences, Acoustics Keywords: Negative cosmic time; cosmological solutions; variable deceleration parameter; big rip

Online: 12 July 2021 (09:46:04 CEST)

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Working Paper ARTICLE

Prognostic Impact of Immunoglobulin Kappa C (IGKC) In Early Breast Cancer

Marcus Schmidt, Karolina Edlund, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, Marco J. Battista, Walburgis Brenner, Annette Hasenburg, Jörg Rahnenführer, Mathias Gehrmann, Pirkko-Liisa Kellokumpu-Lehtinen, Ralph M Wirtz, Heikki Joensuu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: triple-negative breast cancer; prognosis; immune system; immunoglobulin kappa C

Online: 31 May 2021 (12:27:49 CEST)

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Working Paper ARTICLE

Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer

Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader El-Sayes, Karen Mossman, John Valliant

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; immunotherapy; immune checkpoint therapy; radionuclide therapy

Online: 9 April 2021 (13:26:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0689.v1

Alternative Invasion Mechanisms and Host Immune Response to Plasmodium vivax Malaria: Trends and Future Directions

Daniel Kepple, Kareen Pestana, Junya Tomida, Abnet Abebe, Lemu Golassa, Eugenia Lo

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Plasmodium vivax; Erythrocyte Invasion Mechanisms; Duffy Negative; Africa; Immunology; Epidemiology

Online: 27 November 2020 (13:08:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0178.v1

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Melissa Davis, Rachel Martini, Lisa Newman, Olivier Elemento, Jason White, Akanksha Verma, Indrani Datta, Indra Adrianto, Kevin Gardner, Hyung-Gyoon Kim, Windy Dean-Colomb, Isam Eldin Eltoum, Andra R Frost, William E. Grizzle, Andrea Sboner, Upender Manne, Clayton Yates

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; African Ancestry; RNAseq analysis; oncologic pathways

Online: 12 April 2020 (04:22:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0064.v1

On the Trends of Registered Birth and Death Rates in Nigeria: Evidence from Generalized Linear Models

Monday Osagie Adenomon, Emmanuel Chukwuma Anikweze

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: birth; death; trends; generalized linear models (GLMs); poisson; negative binomial

Online: 5 August 2019 (14:36:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0436.v1

Comparing Supervised Machine Learning Strategies and Linguistic Features to Search for Very Negative Opinions

Sattam Almatarneh, Pablo Gamallo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: sentiment analysis; opinion mining; linguistic features; classification; very negative opinions

Online: 19 November 2018 (09:35:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0098.v1

Oyelola A. Adegboye, Majeed Adegboye

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: ecological niche model; environment; overdispersion; negative binomial; leishmaniasis; infectious disease

Online: 27 September 2016 (10:17:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0644.v1

PARP-Targeted Radiotheranostics with Auger Electrons: an Updated Overview

Luca Filippi, Luca Urso, Laura Evangelista

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Auger electrons; radionuclide therapy; prostate cancer; triple negative breast cancer; glioblastoma

Online: 11 March 2024 (18:03:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0406.v1

A Fitted Numerical Scheme with Algorithm for Singularly Perturbed Parabolic Partial Differential Equations with Large Negative Shift

Ababi H. Ejere, Gemechis File Duressa

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Singular perturbation; Boundary layer; Interior layer; Negative shift term; Uniform convergence

Online: 7 October 2023 (09:31:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1363.v1

Breast Cancer in the Arabian Gulf Countries

Humaid O. Al-Shamsi, Nadia Abdelwahed, Amin Abyad, Ibrahim Abu-Gheida, Mehdi Afrit, Tasneem Abu ElFuol, Ryad Alasas, Bilal Lababidi, Prasanta Dash, Mudhasir Ahmad, Norbert W Dreier, Urfan ul haq, Thanda Lucy Ann Joshua, Sonia Otsmane, Anwar Al-Nouri, Aydah Al-Awadhi, Syed Hammad Tirmazy, Faisal Alterkait, Shimaa Elsabae, Nyla Khan, Nehad Albastaki, Yoginee Sonawane, Mohammed Jouda, Frea Perdawood, Faryal Iqbal, Hassan Jaafar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Malignancy; Gulf Cooperation Council(GCC); Survival; HER2; Triple Negative

Online: 20 September 2023 (13:51:45 CEST)

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Breast cancer stands as the prevailing malignancy across all six Gulf Cooperation Council (GCC) nations. In this literature review, we highlighted the incidence and trend of BC in the GCC. Most of the studies reported a consistent increase in BC incidence over the past decades, which was particularly attributed to the adoption of a westernized lifestyle in the region and the implications of emerging risk factors and other environmental and societal factors, the increase in screening uptake, as well as the improvement in data collection and reporting in the GCC. The data about BC risk factors in GCC was limited. In this geographic region, breast cancer frequently manifests with distinctive characteristics, including an early onset, typically occurring before the age of 50, an advanced stage at presentation, and a higher pathological grade. Additionally, it often exhibits more aggressive features such as human epidermal growth factor receptor 2 (HER2) positivity or the presence of triple-negative (TN) attributes, particularly among younger patients. Despite the growing body of literature on breast cancer in the GCC, data pertaining to survival rates are, regrettably, meager. Reports on breast cancer survival rates emanating from the GCC region are largely confined to Saudi Arabia and the United Arab Emirates (UAE). In the UAE, predictive modeling reveals 2-year and 5-year survival rates of 97% and 89%, respectively, for the same period under scrutiny. These rates, when compared to Western counterparts such as Australia (89.5%) and Canada (88.2%), fall within the expected range. Conversely, Saudi Arabia reports a notably lower 5-year survival rate, standing at 72%. This disparity in survival rates underscores the need for further research directed towards elucidating risk factors and barriers that hinder early detection and screening. Additionally, there is a pressing need for expanded data reporting on survival outcomes within the GCC. In sum, a more comprehensive and nuanced understanding of breast cancer dynamics in this region is imperative to inform effective strategies for prevention, early detection, and improved patient outcomes.

Preprint ARTICLE | doi:10.20944/preprints202306.0109.v1

MCAK Inhibitors Induce Aneuploidy in Triple Negative Breast Cancer Models

John C Smith, Stefan Husted, Jay Pilrose, Stephanie C Ems-McClung, Jane R Stout, Richard L Carpenter, Claire E Walczak

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: triple negative breast cancer; MCAK/KIF2C; aneuploidy; chromosomal instability; drug discovery

Online: 1 June 2023 (15:47:29 CEST)

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