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Preprint ARTICLE | doi:10.20944/preprints202002.0054.v1

Distributed Generation from Renewable Energy Sources: Ending Energy Poverty Across the World

Mario Pagliaro, Francesco Meneguzzo

Subject: Engineering, Energy And Fuel Technology Keywords: energy poverty; primary energy; renewable energy; distributed generation; energy storage

Online: 5 February 2020 (03:31:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0033.v4

Circuit-Based Approaches for a Superconducting-Like Behavior with Relatively High Critical Current Density

Shinichi Ishiguri

Subject: Physical Sciences, Condensed Matter Physics Keywords: temperature-independent superconductivity; circuit-approached superconductivity; electron pair; Bose– Einstein condensation; large superconducting energy gap; London equation; Meissner effect; macroscopic wave function; critical current density; negative voltages

Online: 20 February 2024 (22:14:28 CET)

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In general, a superconductor has zero resistance, although it requires significant refrigeration or high pressures with high manufacturing costs, which prevents it into practical applications. In other words, solving these issues implies main superconducting researches. To solve these problems, this paper describes a new type of superconductivity, which is independent for temperatures and which operates without pressures. The principles of the presented system are as follows:First a voltage source, a current source and a load are connected in series. Then, the voltage of the voltage source is adjusted to balance the voltage of the load. Under this condition, the balance of the two voltages provides a zero voltage between the taps of the current source and the generated current from the voltage source becomes zero because of the internal infinite resistance of the current source. As a result, the electric powers generated by the two sources are zero, and therefore, the load cannot generate Joule heating because of energy conservation. However, the current from the current source (not the voltage source) is not zero; therefore, we can predict that the resistance of the load must be zero. As a theory, we derived a new electric field and transient attractive force, which result in a very short coherence of an electron pair because there is not the Coulomb repulsive force due to the existence of the above transient attractive force. Note that both the forces are derived by the Poisson equation, which implies that they cannot be compatible. Therefore, the pair combination energy from spins becomes extremely strong, which is not destroyed by the normal heat energy. Moreover, every center-of-mass motion of electron pair results in the Bose-Einstein condensation and the macroscopic wave function, which produces the London equation (i.e., the Meissner effect). Moreover, by introducing the equivalent circuit, this paper conducted numerical calculations. As a result, we could derive numerically zero resistance and responses for additional static magnetic fields as a discharged current, which implies the Meissner effect. Note that this paper has prepared Appendix section, which provides a guide to reproduce actual experiments and preliminary experimental results. These results in the Appendix indicate the zero resistances and Meissner effects.

Preprint ARTICLE | doi:10.20944/preprints202308.0705.v1

Evaluating the Efficiency of Renewable Energy Technologies: Photovoltaic, Wind Turbine, Battery Bank, and Hydrogen Storage

Gheorghe Lazaroiu, Mohammed Gmal Osman, Strejoiu Cristian-Valentin

Subject: Engineering, Energy And Fuel Technology Keywords: renewable energy; batteries; energy storage; energy challenges

Online: 9 August 2023 (04:24:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0324.v1

An Analysis of Electricity Consumption Patterns in the Water and Wastewater Sectors in South East England, UK

Aman Majid, Iliana Cardenes, Conrad Zorn, Tom Russell, Keith Colquhoun, René Bañares-Alcántara, Jim W. Hall

Subject: Engineering, Energy And Fuel Technology Keywords: water–energy nexus; energy use; energy intensity

Online: 27 November 2019 (03:44:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0644.v1

PARP-Targeted Radiotheranostics with Auger Electrons: an Updated Overview

Luca Filippi, Luca Urso, Laura Evangelista

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Auger electrons; radionuclide therapy; prostate cancer; triple negative breast cancer; glioblastoma

Online: 11 March 2024 (18:03:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0406.v1

A Fitted Numerical Scheme with Algorithm for Singularly Perturbed Parabolic Partial Differential Equations with Large Negative Shift

Ababi H. Ejere, Gemechis File Duressa

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Singular perturbation; Boundary layer; Interior layer; Negative shift term; Uniform convergence

Online: 7 October 2023 (09:31:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1363.v1

Breast Cancer in the Arabian Gulf Countries

Humaid O. Al-Shamsi, Nadia Abdelwahed, Amin Abyad, Ibrahim Abu-Gheida, Mehdi Afrit, Tasneem Abu ElFuol, Ryad Alasas, Bilal Lababidi, Prasanta Dash, Mudhasir Ahmad, Norbert W Dreier, Urfan ul haq, Thanda Lucy Ann Joshua, Sonia Otsmane, Anwar Al-Nouri, Aydah Al-Awadhi, Syed Hammad Tirmazy, Faisal Alterkait, Shimaa Elsabae, Nyla Khan, Nehad Albastaki, Yoginee Sonawane, Mohammed Jouda, Frea Perdawood, Faryal Iqbal, Hassan Jaafar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Malignancy; Gulf Cooperation Council(GCC); Survival; HER2; Triple Negative

Online: 20 September 2023 (13:51:45 CEST)

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Breast cancer stands as the prevailing malignancy across all six Gulf Cooperation Council (GCC) nations. In this literature review, we highlighted the incidence and trend of BC in the GCC. Most of the studies reported a consistent increase in BC incidence over the past decades, which was particularly attributed to the adoption of a westernized lifestyle in the region and the implications of emerging risk factors and other environmental and societal factors, the increase in screening uptake, as well as the improvement in data collection and reporting in the GCC. The data about BC risk factors in GCC was limited. In this geographic region, breast cancer frequently manifests with distinctive characteristics, including an early onset, typically occurring before the age of 50, an advanced stage at presentation, and a higher pathological grade. Additionally, it often exhibits more aggressive features such as human epidermal growth factor receptor 2 (HER2) positivity or the presence of triple-negative (TN) attributes, particularly among younger patients. Despite the growing body of literature on breast cancer in the GCC, data pertaining to survival rates are, regrettably, meager. Reports on breast cancer survival rates emanating from the GCC region are largely confined to Saudi Arabia and the United Arab Emirates (UAE). In the UAE, predictive modeling reveals 2-year and 5-year survival rates of 97% and 89%, respectively, for the same period under scrutiny. These rates, when compared to Western counterparts such as Australia (89.5%) and Canada (88.2%), fall within the expected range. Conversely, Saudi Arabia reports a notably lower 5-year survival rate, standing at 72%. This disparity in survival rates underscores the need for further research directed towards elucidating risk factors and barriers that hinder early detection and screening. Additionally, there is a pressing need for expanded data reporting on survival outcomes within the GCC. In sum, a more comprehensive and nuanced understanding of breast cancer dynamics in this region is imperative to inform effective strategies for prevention, early detection, and improved patient outcomes.

Preprint ARTICLE | doi:10.20944/preprints202306.0109.v1

MCAK Inhibitors Induce Aneuploidy in Triple Negative Breast Cancer Models

John C Smith, Stefan Husted, Jay Pilrose, Stephanie C Ems-McClung, Jane R Stout, Richard L Carpenter, Claire E Walczak

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: triple negative breast cancer; MCAK/KIF2C; aneuploidy; chromosomal instability; drug discovery

Online: 1 June 2023 (15:47:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1852.v1

Beyond Bullying, Aggression, Discrimination, Social Safety: Development of an Integrated Negative Work Behavior Questionnaire (INWBQ)

Cokkie Verschuren, Maria Tims, Annet H. De Lange

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: diagnostic instrument; employee wellbeing; harm; Negative Work Behavior (NWB); bystander roles

Online: 26 May 2023 (04:41:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0080.v1

The Effect of Negative Mass in Gravitating System

Edward Bormashenko

Subject: Physical Sciences, Applied Physics Keywords: core-spring-shell system; gravitating system; negative mass; Coulomb-like forces

Online: 8 April 2022 (11:12:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0133.v1

Phenotypic Heterogeneity Drives Differential Disease Outcome in Triple Negative Breast Cancer

Archana P. Thankamony, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Radhika Nair

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Intratumoral heterogeneity; Triple negative breast cancer (TNBC); Macc1; Phenotypic heteroge-neity

Online: 9 February 2022 (10:40:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0041.v1

Negative-Curvature Spacetime Solutions for Graphene

Antonio Gallerati

Subject: Physical Sciences, Acoustics Keywords: negative-curvature spacetime; field theories in lower dimensions; graphene theoretical physics

Online: 2 November 2020 (13:24:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0527.v1

Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells

Andrew Sulaiman, Sarah McGarry, Jason Chambers, Emil Al-Kadi, Alexandra Phan, Li Li, Karan Mediratta, Jim Dimitroulakos, Christina Addison, Xuguang Li, Lisheng Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; Hypoxia; EGFR; Cisplatin; PDX

Online: 22 July 2020 (11:32:30 CEST)

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Working Paper ARTICLE

Turkish Adaptation of the Positive-Negative Relationship Quality (PN-RQ) Scale: A Reliability and Validity Study

Arzu Araz, Duygu Güngör, Eda Aşçı

Subject: Social Sciences, Psychology Keywords: positive-negative relationship quality; reliability; validity; confirmatory factor analysis (CFA); bifactor

Online: 16 September 2019 (16:33:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0314.v1

From Individual Resource to Social Capital: The Mechanism of How Political Skill Affect Job Satisfaction and Turnover Intention

Yi Li, Mengqiu Ma

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: political skill; job satisfaction; turnover intention; popularity; positive affect; negative affect

Online: 26 December 2018 (12:16:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0263.v1

Geometry of Chalcogenide Negative Curvature Fibers for CO₂ Laser Transmission

Chengli Wei, Curtis R. Menyuk, Jonathan Hu

Subject: Physical Sciences, Optics And Photonics Keywords: CO2 lasers; negative curvature fibers; chalcogenide glass; fiber loss; mid-IR

Online: 16 July 2018 (08:40:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1239.v1

Do Energy Communities Foster Energy Citizenship? A Mixed‐Methods Study of Two Renewable Energy Communities

Aurore Dudka, Natalia Magnani

Subject: Social Sciences, Sociology Keywords: energy citizenship; renewable energy communities; energy cooperatives; engagement

Online: 21 February 2024 (15:41:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0241.v1

Overview of the Potential of Energy Harvesting Sources in Electric Vehicles

Said Bentouba, Nadjet Zioui, Peter Breuhaus, Mahmoud Bourouis

Subject: Engineering, Energy And Fuel Technology Keywords: electric vehicle; energy harvesting; thermal energy; mechanical energy

Online: 5 June 2023 (07:09:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0116.v1

Integrating Solar Energy in Rome's Built Environment: A Perspective for Distributed Generation on Global Scale

Francesco Meneguzzo, Mario Pecoraino, Mario Pagliaro

Subject: Engineering, Energy And Fuel Technology Keywords: solar energy; BIPV; energy transition; energy efficiency; photovoltaics

Online: 12 January 2018 (10:23:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0406.v1

Next Generation Nuclear Power for Non-Power Applications in the Middle-East Region

Joseph D. Smith, Kyle Buchheit, Haider Al-Rubaye, Shoaib Usman, Yishu Zhou, Greg Gelles

Subject: Engineering, Energy And Fuel Technology Keywords: nuclear energy; renewable energy; fossil energy; small modular reactors; resilience; hybrid energy

Online: 31 May 2022 (03:13:28 CEST)

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Working Paper ARTICLE

The Potential Of Simulating Energy Systems: The Multi Energy Systems Simulator Model

Luigi Bottecchia, Pietro Lubello, Pietro Zambelli, Carlo Carcasci, Lukas Kranzl

Subject: Engineering, Energy And Fuel Technology Keywords: Energy System Modelling; Energy Optimization; Energy Simulation; Multi Energy Systems Simulator (MESS)

Online: 21 July 2021 (14:50:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0433.v1

SRT as a Fourth-order-theory with Analogy-model of Damped Resonance

Holger Döring

Subject: Physical Sciences, Acoustics Keywords: SRT; fourth-order-theory; any velocity; FTL; real rest mass; resonance analogy; damped space-time; SR-Extrapolation; superluminal-velocity; negative kinetic energy; fourth-order worldline-element; no-tachyons

Online: 16 April 2021 (10:42:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0703.v5

On the Fundamental Particles and Reactions of Nature

Jian-Bin Bao, Nicholas P. Bao

Subject: Physical Sciences, Quantum Science And Technology Keywords: aether; hypoatom; neutrino; inflation; gravity; negative pressure; dark energy; dark matter; black hole; spinning universe; quantum mechanics; first galaxies; spin-1/2 particle; matter-antimatter asymmetry; baryogenesis-through-leptogenesis; fabric of space; conformal cyclic cosmology; center of the universe; fate of the universe; general theory of relativity; parity non-conservation in weak interactions

Online: 4 January 2023 (02:26:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0154.v1

Solar Energy: Revolutionizing Shipping Industry Towards Sustainability and Environmental Stewardship

Olga Petrychenko, Maksym Levinskyi, Sergey Goolak, Vaidas Lukoševičius

Subject: Engineering, Marine Engineering Keywords: solar energy; sustainable energy; green energy; on-renewable energy sources; environmentally friendly future

Online: 2 February 2024 (10:27:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1567.v1

Energy Imbalance Gap Was Associated with Body Mass Index and Sex in Latin American Adolescents—Results from the ELANS Study

Pablo Hernandez, Marianella Herrera-Cuenca, Gerson Ferrari, Rafaela Yépez Almeida, Martha Cecilia Yépez García, Mónica Villar Cáceres, Lilia Yadira Cortés Sanabria, Yaritza Sifontes, Maritza Landaeta-Jimenez, Georgina Gómez, Rafael Monge-Rojas, Rossina Pareja, Attilio Rigotti, Irina Kovalskys, Mauro Fisberg

Subject: Public Health And Healthcare, Other Keywords: energy balance; energy expenditure; energy intake; energy imbalance gap; underweight; overweight; Latin America

Online: 26 November 2023 (05:24:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0496.v1

Analysis of Energy Efficiency Opportunities for a Public Transportation Maintenance Facility—A Case Study

Jordan Higgins, Aditya Ramnarayan, Roxana Family, MICHAEL M OHADI

Subject: Engineering, Energy And Fuel Technology Keywords: Energy Audit; Energy Modeling; Energy Efficiency; Transportation Maintenance Facility

Online: 8 March 2024 (09:18:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0448.v1

Method and Simulation of a Power Supply System Operation Based on Methane Generator Supported by Energy Storage System, to Cover High Fluctuation Electrical Loads: Greenhouse Case Study

Costas Elmasides

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Energy Storage System; Energy saving in greenhouses; Energy Management

Online: 7 February 2024 (13:29:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0311.v1

Analysis of Influencing Factors of the Energy Transition Process in Sustainable Nautical Tourism

Raluca Florentina Crețu, Silviu Gheorghe, Elena Claudia Șerban, Daniela Țuțui, Romeo Cătălin Crețu

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: sustainability; energy transition; nautical tourism; energy independence; renewable energy

Online: 3 August 2023 (10:45:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints201710.0198.v1

Energy Policies and Sustainable Management of Energy Sources

Luigi Schirone, Filippo Pellitteri

Subject: Social Sciences, Other Keywords: Sustainability; energy sources; renewable sources; energy efficiency; energy demand

Online: 31 October 2017 (16:12:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0140.v1

Efficiency Increase of Vibratory Energy Harvesting Circuits by Multi-Harvester Strategy Design

Javier Ortiz , Josu Etxaniz, Nieves Murillo, Joseba Zubia, Gerardo Aranguren Aramendia

Subject: Engineering, Electrical And Electronic Engineering Keywords: Energy Harvesting; energy management circuit; kinetic energy; vibratory transducer

Online: 17 March 2017 (16:58:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0946.v1

Finding Negative Associations from Medical Data Streams Based on Frequent and Regular Patterns

RajaRao Budaraju, Sastry Kodanda Rama Jammalamadaka

Subject: Computer Science And Mathematics, Computer Science Keywords: Data streams; Negative associations; Adverse effects; side reactions; Frequent and Regular patterns

Online: 19 February 2024 (11:35:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0115.v3

Antibacterial Activity and Mechanisms of Plant Flavonoids against Gram-Negative Bacteria Based on the Antibacterial Statistical Model

Yu Yan, Xuexue Xia, Aiman Fatima, Li Zhang, Ganjun Yuan, Fengxian Lian, Yu Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: Action mode; Antimicrobial; Escherichia coli; Flavonoids; Gram-negative bacteria; Gram-positive bacteria; Lipophilicity; LogP; MIC; Statistical model

Online: 20 February 2024 (10:48:13 CET)

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The antimicrobial quantitative structure–activity relationship of plant flavonoids against Gram-positive bacteria was established in our previous works, and the cell membrane was confirmed as a major site of action. To investigate whether plant flavonoids have similar antibacterial effects and mechanisms against both Gram-negative and Gram-positive bacteria, here, the minimum inhibitory concentrations (MICs) of 37 plant flavonoids against Escherichia coli were determined using the microdilution broth method, and then the correlation between their lipophilic parameter ACD/LogP or LogD_7.40 value and their MIC was analyzed. Simultaneously, the correlation between the ACD/LogP or LogD_7.40 value and the MIC of 46 plant flavonoids reported in literature against E. coli was also analyzed. Both sets of results showed that there is a significant correlation between the LogP value and the MIC of plant flavonoids against Gram-negative bacteria. However, it is difficult to effectively predict the MIC of plant flavonoids against Gram-negative bacteria from their lipophilic parameters. By comparing two regression curves derived from plant flavonoids against Gram-negative and Gram-positive bacteria, it was further discovered that the antibacterial activities of most plant flavonoids against Gram-negative bacteria are stronger than those against Gram-positive bacteria when their LogP values are less than about 3.0, but the opposite is true when their LogP values are more than about 3.6. Moreover, this comparison also suggests that unlike mainly acting on the cell membrane of Gram-positive bacteria, plant flavonoids have multiple mechanisms against Gram-negative species, while the cell membrane is also an important action site among them. Combined with the correlation analyses between the enzyme inhibitory activity and the LogP value of the reported flavonoids, it was further suggested that DNA gyrase is another important target of plant flavonoids against Gram-negative bacteria.

Preprint ARTICLE | doi:10.20944/preprints202311.1720.v1

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

Samantha Greaves, Caroline Harvey, Yashuhiro Kotera

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate change; positive and negative affect; pro-environmental behavioural intentions; climate anxiety

Online: 28 November 2023 (08:15:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0110.v1

Plasmid-Mediated Genes Were Responsible for the Resistance and Spread of Metallo Beta-Lactamase (MBL)-Producing Pseudomonas Aeruginosa Isolates in Poultry Milieus

Chika Ejikeugwu, Carissa Duru, Euslar Onu, Emmanuel Nwakaeze, Cyril Adonu, Ndidiamaka Okorie, Nonye Ujam, Ijeoma Ebenebe, Theodora Mba, Anthonia Mba, Chika Ezeador, Chijioke Edeh, Malachy Ugwu, Michael Adikwu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Gram negative bacteria; multidrug resistance; plasmids; carbapenemase; carbapenems; mobile genetic elements (MGEs)

Online: 4 September 2023 (07:17:41 CEST)

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Bacterial resistance to antibiotics is a public health menace that needs urgent efforts to mitigate and forestall their transmission in the general environment. Plasmid-mediated metallo beta-lactamase (MBL) gives bacteria an exceptional ability to transmit resistance genes. This study investigated plasmid-mediated resistance in MBL P. aeruginosa isolates from poultry food chain settings. Cloacal swab samples (n=120) were bacteriologically analyzed for the isolation of P. aeruginosa isolates. Susceptibility studies were performed by the CLSI guideline using selected antibiotics. MBL was phenotypically detected using modified Hodges test, and confirmed using PCR technique. Plasmid curing studies detected the presence of plasmids in the isolates. P. aeruginosa isolates (n=48) showed high levels of reduced susceptibility to cefoxitin (93.8%), imipenem (81.3%), gentamicin (85.4%), amikacin (85.4%), nitrofurantoin (83.3%), ofloxacin (72.9%) and cefotaxime (77.1%). MBL was phenotypically detected in 7 (14%) isolates of P. aeruginosa. The presence of blaIMP-1 and blaIMP-2 MBL genes in P. aeruginosa (n=5) isolates was confirmed by PCR. The PCR did not detect blaVIM-1 and blaVIM-2 MBL genes. The P. aeruginosa isolates were multidrug resistant, with about 50% of the isolates showing multidrug resistance (MDR) to the antibiotics. The genes for MDR in the P. aeruginosa isolates were borne on plasmids, indicating a high possibility of community transmission of MBL resistance genes. Finally, the P. aeruginosa isolates from poultry food chain milieus are multidrug resistant, produce MBL, and harbour their resistance genes on plasmids. Since many antibiotic resistance genes in bacteria are associated with mobile genetic elements (MGEs) like plasmids, it is important to step up actions to mitigate incessant use of antibiotics in poultry and other agricultural practices in Nigeria in order to diminish the evolution and spread of plasmid-mediated resistance which is capable of initiating community acquired infections that may prove difficult to treat in our hospitals with the available antibiotics.

Preprint REVIEW | doi:10.20944/preprints202308.2077.v1

A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis

Klaus Brandenburg, Raquel Ferrer-Espada, Guillermo Martinez De Tejada, Christian Nehls, Satoshi Fukuoka, Karl Mauss, Günther Weindl, Patrick Garidel

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: sepsis; lipopolysaccharide; gram-negative bacteria; covid pandemic; hyperinflammation; TLR4; cytokines; ARDS; Aspidasept

Online: 31 August 2023 (03:41:27 CEST)

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Sepsis is a life-threatening condition caused by the body's overwhelming response to an infection, such as pneumonia or urinary tract infection. It occurs when the immune system releases cytokines into the bloodstream, triggering widespread inflammation. If not treated, it can lead to organ failure and death. Unfortunately, sepsis has a high mortality rate, with studies reporting rates ranging from 20% to over 50%, depending on the severity and promptness of treatment. According to the World Health Organization (WHO), the annual death toll in the world is about 11 million. One of the main toxins responsible for inflammation induction are lipopolysaccharides (LPS, endotoxin) from Gram-negative bacteria, which ranks among the most potent immunostimulants found in nature. Antibiotics are consistently prescribed as a part of anti-sepsis-therapy. However, antibiotic therapy (i) is increasingly ineffective due to resistance development and (ii) most antibiotics are unable to bind and neutralize LPS, a prerequisite to inhibit the interaction of endotoxin with its cellular receptor complex, namely Toll-like receptor 4 (TLR4)/MD-2, responsible for the intracellular cascade leading to pro-inflammatory cytokine secretion. The pandemic virus SARS-CoV-2 has infected hundreds of millions of humans worldwide since its emergence in 2019. The COVID-19 (Coronavirus disease-19) caused by this virus is associated with high lethality, particularly for elderly and immunocompromised people. As of August 2023, nearly 7 million deaths were reported worldwide due to this disease. According to some reported studies, upregulation of TLR4 and the subsequent inflammatory signaling detected in COVID-19 patients “mimics bacterial sepsis”. Furthermore, the immune response to SARS-CoV-2 was described by others as “mirror image of sepsis”. Similarly, the cytokine profile in sera from severe COVID-19 patients was very similar to those suffering from the acute respiratory distress syndrome (ARDS) and sepsis. Finally, the severe COVID-19 infection was frequently accompanied by bacterial co-infections, as well as by the presence of significant LPS concentrations. These data indicate similarity and interdependences of both syndromes, but also significant differences which will be discussed in the present review.

Preprint ARTICLE | doi:10.20944/preprints202306.1836.v1

Conversion of Polypropylene (PP) foams into Auxetic Metamaterials

Xiao Yuan Chen, Denis Rodrigue

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Polypropylene; foam; upcycling; negative Poisson's ratio; auxetic materials; cellular structure; mechanical properties.

Online: 26 June 2023 (21:55:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0434.v1

Identification of a NACC1-Regulated Gene Signature Impli-Cated in the Features of Triple-Negative Breast Cancer

Xia Liu, Chrispus Ngule, Hami Hemati, Oluwafunminiyi Obaleye, Amos Oyelami, Felix Oyelami, Xingcong Ren, Jianxun Song, Xiaofang Xiong, Jin-ming Yang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Tumor progression; cancer stem cells; gene signature; NACC1; triple negative breast cancer

Online: 27 February 2023 (03:10:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0296.v1

N10-C11 Imine is Essential for Gram-negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines

Pietro Picconi, Charlotte K. Hind, J. Mark Sutton, Khondaker Miraz Rahman

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: antimicrobial resistance; broad-spectrum antibiotics; antibacterial drug discovery; gram-negative bacteria; pyrrolobenzodiazepines

Online: 16 November 2022 (04:20:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0433.v1

Spiropyran/Merocyanine Amphiphile in Various Solvents: A Joint Experimental–Theoretical Approach to Photophysical Properties and Self-Assembly

Vladyslav Savchenko, Nino Lomadze, Svetlana Santer, Olga Guskova

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: spiropyran/merocyanine isomerization; negative photochromism; time-resolved UV-vis measurements; molecular modeling

Online: 25 August 2022 (10:22:35 CEST)

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This joint experimental-theoretical work focuses on molecular and photophysical properties of the spiropyran-containing amphiphilic molecule in organic and aqueous solutions. Being dissolved in tested organic solvents, the system demonstrates positive photochromism, i.e. upon UV stimulus the colorless spiropyran form is transformed into colorful merocyanine isomer. However, aqueous solution of the amphiphile possesses a negative photochromism: the orange-red merocyanine form turns to be thermodynamically more stable in water, and both UV and vis stimuli lead to the partial or complete photobleaching of the solution. The explanation of this phenomenon is given on the basis of density functional theory calculations and classical modeling including thermodynamic integration. The simulations reveal that stabilization of merocyanine in water proceeds with the energy of ca. 70 kJ mol−1, and that the Helmholtz free energy of hydration of merocyanine form is 100 kJ mol−1 lower as compared to the behavior of SP isomer in water. The explanation of such a difference lies in the molecular properties of the merocyanine: after ring-opening reaction this molecule transforms into a zwitterionic form, as evidenced by the electrostatic potential plotted around the opened form. The presence of three charged groups on the periphery of a flat conjugated backbone stimulates the self-assembly of merocyanine molecules in water, ending up with the formation of elongated associates with stack-like building blocks, as shown in molecular dynamics simulations of the aqueous solution with the concentration above critical micelle concentration. Our quantitative evaluation of the hydrophilicity switching in spiropyran/merocyanine containing surfactants may prompt the search for new systems, including colloidal and polymeric ones, aiming at remote tuning of their morphology, which could give new promising shapes and patterns for the needs of modern nanotechnology.

Preprint ARTICLE | doi:10.20944/preprints202206.0233.v1

Social Robots Outdo the Not-so-Social Media for Self-disclosure: Safe Machines Preferred to Unsafe Humans?

Rowling Luo, Thea Zhang, Derrick Chen, Johan F. Hoorn, Ivy Huang

Subject: Business, Economics And Management, Accounting And Taxation Keywords: social media; social robots; negative mood; self-disclosure; intervention design; anthropomorphic design

Online: 16 June 2022 (06:11:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0297.v1

The Effect of Intratumoral Interrelation among FOXP3+ Regulatory T cells on Treatment Response and Survival in Triple-Negative Breast Cancer

Noriko Goda, Chika Nakashima, Ichiro Nagamine, Sunao Otagaki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: regulatory T cell; tumor-infiltrating lymphocyte; neoadjuvant chemotherapy; triple-negative breast cancer

Online: 22 March 2022 (07:50:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0130.v1

A Novel Treatment of the Josephson Effect

Jacob Szeftel, Nicolas Sandeau, Michel Abou Ganthous

Subject: Physical Sciences, Acoustics Keywords: Josephson effect; transport properties; critical current; tunnelling; superconducting-normal transition; negative resistance

Online: 4 February 2021 (10:01:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0568.v1

Perceived Help-Seeking Difficulty, Barriers, Delay, and Burden in Carers of People with Suspected Dementia

Carmen KM Ng, Dara KY Leung, Xinxin Cai, Gloria HY Wong

Subject: Business, Economics And Management, Accounting And Taxation Keywords: service accessibility; dementia knowledge; affordability; carer role strain; self-criticism; negative emotions

Online: 27 January 2021 (16:15:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0279.v2

COVID-19 Testing – Impact of Prevalence, Sensitivity, and Specificity on Patient Risk and Cost

Zoe C. Brooks, Saswati Das

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID19; risk; clinical; metrics; cost; false-positive; false-negative; prevalence; sensitivity; specificity

Online: 9 July 2020 (15:57:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0117.v1

Using Negative Pressure Wound Therapy in the Treatment of Wounds After Fasciotomy in Acute Compartment Syndrome - Retrospective Case Series Study

Jaroslaw P. Miszczuk, Maria Błońska-Staniec, Anna Michalska, Bartosz Stemplewski

Subject: Medicine And Pharmacology, Surgery Keywords: acute compartment syndrome; negative pressure wound therapy; vacuum assisted wound closure; fasciotomy

Online: 8 April 2020 (04:50:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0225.v1

Analysis of Water Bodies under Partial Cloud Conditions Using Satellite Images

Rahul Neware, Mansi Thakare

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: water bodies; satellite images; vector data; SVM; positive and negative buffering; polygons

Online: 21 August 2019 (10:30:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0533.v1

Energy Transition: Questioning the Underlying Assumptions

Chris Butters, Ove Daniel Jakobsen

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Energy transition; energy policy; energy economy; sustainable energy; ecological economics; green economy; energy justice; sustainable development goals; wellbeing

Online: 8 February 2024 (15:53:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0279.v1

Energy Situation in the Republic of Serbia

Dejan Brkić

Subject: Engineering, Energy And Fuel Technology Keywords: Serbia, Energy policy, Energy sectors

Online: 15 August 2018 (16:06:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1366.v1

Long-Term Forecast of Energy Demand Towards a Sustainable Future in Renewable Energies focused on Geothermal Energy in Peru (2020–2050): A LEAP Model Application

Diego G. De la Cruz Torres, Luis F. Mazadiego, David Bolonio Martín, Ramón Rodríguez Pons-Esparver

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: Energy efficiency; climate change; renewable energy; fossil fuels; geothermal energy; greenhouse gases; energy demand

Online: 22 April 2024 (10:16:48 CEST)

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The purpose of the evaluation of the Peruvian energy generation system is to project the electricity generation and demand until the year 2050. To achieve this, three alternative scenarios have been defined and analyzed using the LEAP (Long-range Energy Alternatives Planning) software. The scenarios are as follows: the first one, Business-as-Usual scenario, based on normal trends according to historical data and referencing projections made by Peruvian state entities; the second one is focused on Energy Efficiency, the highlighted characteristic is taking into consideration the efficient conditions in transmission and distribution of electric energy; and the third one, centered on Geothermal Energy, focused on the development of this type of energy source and prioritizing it. The primary purpose of this analysis is to identity advantages and disadvantages inherent in each scenario in order to get the best of each one. In this way, the intention is to propose solutions based on Peru’s national reality or possible uses of the country’s energy potential to supply its energy demand. Currently, Peru’s energy demand relies on fossil fuels, hydraulic, and thermal energy. However, there is the possibility of transforming this system into a sustainable one, by strengthening existing and growing energy sources such as solar and wind energy, and new technologies for hydraulic and thermal energy, in addition to considering geothermal energy as the main energy source in the third scenario. The new system mentioned satisfactorily indicate that the CO2 equivalent emissions decrease significantly in the third scenario, with a 15.8% reduction compared to the first scenario and a 9.7% reduction in comparison to the second. On the other hand, the second scenario shows a 5.6% decrease in CO2 emissions compared to the first, resulting from improvements in technology and energy efficiency without requiring significant modifications or considerable investments, as in the third scenario.

Preprint ARTICLE | doi:10.20944/preprints202309.1236.v1

Performance Analysis of a Diabatic CAES System Fuelled with Green Hydrogen

Luca Migliari, Davide Micheletto, Daniele Cocco

Subject: Engineering, Energy And Fuel Technology Keywords: Compressed Air Energy Storage; Hydrogen; Photovoltaic; Energy Storage; Power flexibility; Ancillary services; Renewable; Energy Shift; Energy Independence; Energy Transition

Online: 19 September 2023 (04:36:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1596.v1

Analysis Methodology for the Evaluation of Energy Efficiency and Energy Classification of Buildings in the Residential Sector

María Adelaida Pavón Tapia, Diego Carmona Fernández, Dorotea Dimitrova Angelova, Juan Félix González González

Subject: Energy And Fuel Technology, Engineering Keywords: Energy efficiency; energy rating; energy analysis; residential sector; data processing

Online: 24 April 2024 (08:28:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0690.v1

Development of a Consistent Understanding of Energy, Energy Conservation, and Derivation of a Systematic Set of Energy Forms

Harald Mehling

Subject: Physical Sciences, Theoretical Physics Keywords: energy; definition; explanation; energy conservation; energy form; interaction

Online: 9 January 2024 (04:51:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0693.v1

Machine Learning Dynamic Ensemble Methods for Solar Irradiance and Wind Speed Predictions

Francisco Diego Vidal Bezerra, Felipe Pinto Marinho, Paulo Alexandre Costa Rocha, Victor Oliveira Santos, Jesse Van Griensven Thé, Bahram Gharabaghi

Subject: Engineering, Mechanical Engineering Keywords: wind energy; solar energy; renewable energy; machine learning; forecasting ensembles

Online: 9 August 2023 (10:56:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0413.v1

Life Cycle Analysis of a Geothermal Power Plant: Comparison of the Environmental Performance with Other Renewable Energy Systems

Riccardo Basosi, Roberto Bonciani, Dario Frosali, Giampaolo Manfrida, Maria Laura Parisi, Franco Sansone

Subject: Engineering, Energy And Fuel Technology Keywords: geothermal energy; life cycle analysis; solar photovoltaic energy; wind energy

Online: 28 February 2020 (01:34:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0299.v1

Assessment of the Current Energy Consumption of Residential Buildings in Jeddah, Saudi Arabia

Ahmed Felimban, Alejandro Prieto, Ulrich Knaack, Tillmann Klein, Yasser Qaffas

Subject: Engineering, Energy And Fuel Technology Keywords: Energy Consumption, Saudi Arabia, Renewable Energy, Building Envelope, Energy Efficiency

Online: 28 June 2019 (12:37:43 CEST)

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In the Kingdom of Saudi Arabia (KSA), residential buildings’ energy consumption accounts for almost 50% of the building stock electricity consumption. The electricity generation consumes over one-third of the daily oil production. KSA was ranked as one of the highest countries in fossil fuel consumption per capita in 2014. Moreover, the KSA’s economy heavily relies on fossil fuel sources, namely oil reservoirs, whereby depletion will negatively affect the future development of the country. The total electricity consumption is annually growing by approximately 5-8%, which would lead to identical oil consumption to oil production in 2035. Currently, the KSA government is concerned to generate more renewable energy using large renewable energy plants. The government is investing in energy generation through renewable sources, by financing large scale photovoltaic farms to stop an economic crisis that may occur in 2035. The existing building stock consumes around 80% of the total current Saudi electricity that is generated. According to the Saudi energy efficiency report, the primary energy consumption per capita is over three times higher than the world average. Therefore, the residential buildings need further assessment as to their current energy consumption. This research used a survey to explore current user behaviour in residential buildings energy performance in the city of Jeddah, KSA. The findings of the survey showed: • The buildings thermal properties were found to be poorly designed • The majority of users within the buildings prefer a room temperature of below 24 °C, which requires a massive amount of cooling • Due to the climate conditions and the cultural aspects of KSA, housing units are occupied for more than 18 hours per day • An increase in user awareness has helped to slightly improve residential buildings energy efficiency Knowing the current high energy consumption sources and causes and being able to define available opportunities for further developments on building thermal properties enhancements and how to increase user awareness to reach self-sustaining buildings is essential.

Preprint CASE REPORT | doi:10.20944/preprints201807.0358.v1

Energy Diagnosis of University Buildings: Renewable Energy Institute from UNAM

Oscar González, Miguel Morales, Carla Seefoó, David Morillón, Hugo Valdés

Subject: Engineering, Energy And Fuel Technology Keywords: energy diagnosis; energy efficiency; UNAM; IER; energy consumption and demand

Online: 19 July 2018 (11:36:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1241.v1

Power to the People – on the Role of Districts in Decentralized Energy Systems

Jonas Schnidrig, Arthur Chuat, Cédric Terrier, François Maréchal, Manuele Margni

Subject: Engineering, Energy And Fuel Technology Keywords: energy system optimization; renewable energy; decentralization; self-consumption; renewable energy hub; carbon neutrality; energy independence

Online: 23 February 2024 (06:29:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.1564.v1

Rethinking Notions of Energy Efficiency in a Global Context

Patrick Moriarty, Damon Honnery

Subject: Engineering, Energy And Fuel Technology Keywords: buildings energy efficiency; climate change; energy efficiency; feedback effects; passive solar energy; renewable energy; transport energy efficiency; urban heat island

Online: 23 May 2023 (04:32:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0582.v1

Module-Type Triboelectric Nanogenerators Capable of Harvesting Power from a Variety of Mechanical Energy Sources

Jaehee Shin, Sungho Ji, Jiyoung Yoon, Jinhyoung Park

Subject: Engineering, Automotive Engineering Keywords: energy harvesting; triboelectric nanogenerators; vibration energy

Online: 26 July 2021 (14:26:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1186.v1

Factors Contributing to Negative Outcomes Associated with Medications and Drug-Related Problems in Kidney Replacement Therapy. A Hospital-Based Prospective Observational Study

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Aurora Polo-Moyano, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: kidney replacement therapy; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 January 2024 (13:57:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1186.v1

Distinction between Effects of IR-Drop and Negative Capacitance of Fast Cyclic Voltammograms

Yuanyuan Liu, Koichi Jeremiah Aoki, Jingyuan Chen

Subject: Chemistry And Materials Science, Electrochemistry Keywords: IR-drop; negative capacitance; double layer capacitance; fast scan cyclic voltammograms; microelectrode reactions

Online: 16 August 2023 (10:44:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1601.v1

Antimicrobial Potential of the Microalgae Extracts

Alexander Lykov, Alexei Salmin, Ruslan Gevorgiz, Svetlana Zheleznova, Lyubov Rachkovskaya, Maria Surovtseva, Olga Poveshchenko

Subject: Biology And Life Sciences, Life Sciences Keywords: diatoms; cyanobacter; green microalgae; Gram-positive and Gram-negative bacteria; Mycobacteria; antimicrobial potential

Online: 24 July 2023 (10:46:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0858.v1

Mortality Due to Multi-Drug Resistant Gram Negative Bacteremia in an Endemic Region: No Better than Toss a Coin

Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Gram-negative bacilli bacteremia; multidrug resistance; 28-day mortality; procalcitonin; rapid molecular diagnostics

Online: 11 May 2023 (13:34:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

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Working Paper ARTICLE

Negative Effective Mass in Plasmonic Systems, II: Elucidating of Optical and Acoustical Branches of Vibrations and the Possibility of Anti-Resonance Propagation

Edward Bormashenko, Irina Legchenkova, Mark Frenkel

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: metamaterials; negative effective mass; plasma oscillations; low frequency plasmons; optical and acoustical branches.

Online: 21 July 2020 (13:38:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints201910.0255.v1

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-negative (ESKAPEE) Bacteria

Akif Reza, J. Mark Sutton, Khondaker Miraz Rahman

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: antimicrobial resistance; biofilm; efflux pump inhibitors; antibiotic potentiation; eskapee pathogens; gram-negative bacteria

Online: 22 October 2019 (10:22:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0026.v1

Weighted Negative Binomial Poisson-Lindley Distribution with Actuarial Applications

Hossein Zamani, Noriszura Ismail, Marzieh Shekari

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: weighted distribution; Poisson-Lindley distribution; discrete distribution; weighted negative binomial Poisson-Lindley distribution

Online: 2 May 2018 (11:47:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0605.v1

A Comprehensive Overview of Photovoltaic Technologies and their Efficiency for a Climate Neutrality

Alexandra Catalina Lazaroiu, Mohammed Gmal Osman, Cristian-Valentin Strejoiu, Gheorghe Lazaroiu

Subject: Engineering, Energy And Fuel Technology Keywords: Renewable energy; Greenhouse gas emissions; sustainable energy system; clean energy; sustainability

Online: 10 October 2023 (08:36:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0495.v1

Increasing the Voltage – Sequencing Decarbonisation With Green Power & Efficiency

Stefan M. Buettner, Josefine Döpp, Liane Strauch, Marina Gilles, Werner König, Anna-Lena Klingler

Subject: Business, Economics And Management, Economics Keywords: decarbonisation; energy supply security; energy demand; energy systems; industry; capacity planning

Online: 28 February 2023 (02:53:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0313.v1

Economic Modelling for Self-consumption of Roof-Top Photovoltaic Systems in Spain

Álvaro Rodríguez-Martínez, Carlos Rodríguez-Monroy

Subject: Business, Economics And Management, Economics Keywords: sustainability; solar energy; photovoltaic energy; renewable energy; self-consumption; rooftop pv

Online: 17 September 2021 (12:29:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0069.v1

Modeling County-Level Energy Demands for Commercial Buildings due to Climate Variability with Prototype Building Simulations

Daniel Mendoza, Carlo Bianchi, Jermy Thomas, Zahra Ghaemi, Amanda Smith

Subject: Engineering, Mechanical Engineering Keywords: building energy modeling; energy systems; energy demand; future climate; weather files

Online: 7 October 2019 (12:19:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0086.v1

Neiwan Hydro Powerhouse (A Conceptual Reconstruction Study)

Stefan Tkac

Subject: Engineering, Civil Engineering Keywords: hydro-power; hydro-power plant; micro-energy; renewable energy; water energy

Online: 11 February 2019 (09:05:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0127.v1

Micro hydro Power Plant Shanping (Site Reconstruction)

Štefan Tkáč

Subject: Engineering, Energy And Fuel Technology Keywords: hydro-power; hydro-power plant; micro-energy; renewable energy; water energy

Online: 11 December 2018 (10:46:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201811.0568.v1

From Renewable to Marine Energies Sources for Sustainable Development and Energy Transition in Morocco: Current Status and Scenario

Mostapha Tarfaoui, Mourad Nachtane, Youssef Amry, Ahmed El Moumen

Subject: Engineering, Energy And Fuel Technology Keywords: energy transition; sustainable development; efficiency energy; renewable energy; marine natural resources

Online: 26 November 2018 (03:50:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0381.v1

Integrated Energy Micro-Grid Planning Using Electricity, Heating and Cooling Demands

He HUANG, DaPeng Liang, Zhen Tong

Subject: Engineering, Electrical And Electronic Engineering Keywords: energy internet; multi-energy complementary; integrated energy systems; distribution network planning

Online: 19 September 2018 (10:22:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0514.v2

Integrating Solar PV System with Pumped Hydroelectric Storage at Mutah University of Jordan

Mahmoud Zeidan, Mohammed Al-soud, Mothana Dmour, Zuhier Alakayleh, Safwan Al-Qawabah

Subject: Engineering, Mechanical Engineering Keywords: photovoltaic systems; pumped hydroelectric; energy storage systems; annual energy production-energy demand.

Online: 11 July 2023 (10:17:09 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.0047.v1

Rethinking the Term "Energy Deficiency": A Critique of Oversimplification in Nutrition and Metabolism

Anssi H Manninen

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: energy deficiency; energy balance; energy flux; terminology; mitochondrial diseases; glycogen storage diseases

Online: 1 June 2023 (07:26:40 CEST)

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This brief commentary challenges the use of the term "energy deficiency" in nutrition and metabolism, providing a critical examination of its scientific and philosophical aspects. It emphasizes the need to consider rare diseases associated with actual energy deficiency, which extend beyond the scope of everyday tiredness or fatigue. By analyzing energy balance and its complexities, this critique underscores the oversimplification associated with the term and its potential for misleading implications. It highlights the dynamic nature of energy metabolism and the intricate mechanisms involved in maintaining energy equilibrium, including the impact of rare genetic and physiological abnormalities. In addition to the discussion on energy balance, this commentary explores the manifestation of rare diseases that disrupt energy production, utilization, or hormonal regulation. Conditions such as mitochondrial diseases, glycogen storage diseases, adrenal insufficiency, and Prader-Willi syndrome are examined, shedding light on their profound impact on individuals' energy levels and overall health. The distinct time courses, underlying mechanisms, and clinical implications of protein deficiency, energy deficiency, and vitamin C deficiency are also compared, further emphasizing the complexity of energy metabolism and its relationship with various nutrient deficiencies. To foster a more comprehensive understanding of energy metabolism and enhance clarity in communication within the field, the commentary proposes the adoption of alternative terminology, such as "energy flux," to capture the multifaceted nature of energy balance more accurately. By reevaluating the terminology employed, researchers and healthcare professionals can better convey the intricate dynamics of energy metabolism and address the unique challenges faced by individuals with rare diseases causing actual energy deficiency. In conclusion, this commentary serves as a thought-provoking exploration of the concept of energy deficiency in nutrition and metabolism. It highlights the limitations of the term in capturing the complexities of energy balance, particularly in the context of rare diseases. By broadening the discussion to include these rare conditions, it encourages a more comprehensive understanding of energy metabolism and calls for precise and nuanced terminology to facilitate effective communication and advancements in the field.

Preprint ARTICLE | doi:10.20944/preprints201810.0662.v1

Current Situation and Future Perspectives of the Romanian Renewable Energy

Ştefan Dragoş Cîrstea, Claudia Steluţa Martiş, Andreea Cîrstea, Anca Constinescu-Dobra, Melinda Timea Fulop

Subject: Engineering, Energy And Fuel Technology Keywords: renewable energy; future perspectives; renewable energy sources; Romania energy structure; exploratory study

Online: 29 October 2018 (07:22:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0253.v1

3D Visualization Solution to Building Energy Diagnosis for Energy Feedback

Tae-Keun Oh, Donghwan Lee, Minsoo Park, Gichun Cha, Seunghee Park

Subject: Engineering, Energy And Fuel Technology Keywords: energy diagnosis; close-range photogrammetry; energy efficiency; visualization of information; energy feedback

Online: 17 May 2018 (13:31:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0144.v1

Adaptable Energy Systems Integration by Modular, Standardized and Scalable System Architectures: Necessities and Prospects of Any Time Transition

Jonas Hinker, Thomas Wohlfahrt, Emily Drewing, Sergio Felipe Contreras Paredes, Daniel Mayorga Gonzalez, Johanna M.A. Myrzik

Subject: Engineering, Electrical And Electronic Engineering Keywords: energy infrastructure design; system architecture; energy transition; district heating systems (DHS); energy hubs; distributed multigeneration (DMG); multi-energy systems (MES); urban energy systems (UES); community energy; societal prospects

Online: 22 February 2018 (12:47:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1183.v1

The Energy Saving Potential in an Office Building Using Louvers in Mid-Latitude Climate Condition

Seoyong Shin, Ngoc Minh Kieu, Irfan Ullah, Jongbin Park, Hojune Bae, Meeryoung Cho, Gunwoo Lee

Subject: Engineering, Energy And Fuel Technology Keywords: Louvers; visual comfort; energy-saving; energy-simulation

Online: 16 January 2024 (08:21:41 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202401.0058.v1

Unified Field Theory: Mathematical Modeling of Strong Energy as the Singular Source of Energy Manifestations

humaira ashraf

Subject: Environmental And Earth Sciences, Other Keywords: unified energy; cosmology; particle physics; energy studies

Online: 2 January 2024 (09:36:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0194.v1

Energy Sufficiency policy approach to geopolitical risks and rising energy prices

Jānis Brizga, Michael Søgaard Jørgensen, Gunnar Boye Olesen, Vidas Lekavicius

Subject: Environmental And Earth Sciences, Environmental Science Keywords: sufficiency; energy crises; energy poverty; policy instruments

Online: 2 August 2023 (08:37:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1032.v1

A Review of Combined Heat and Power (CHP)

Wenjing Ma, Wei Han, Qibin Liu, Gang Xu

Subject: Engineering, Electrical And Electronic Engineering Keywords: CHP; Cascade utilization of energy; Energy level

Online: 27 April 2023 (04:23:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0467.v1

Energy Efficiency in OECD Countries: A DEA Approach

Filip Fidanoski, Kiril Simeonovski, Violeta Cvetkoska

Subject: Engineering, Automotive Engineering Keywords: energy efficiency; primary energy; electricity; DEA analysis

Online: 25 January 2021 (10:12:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0205.v1

Energy Management of Community Microgrids Considering Uncertainty using Particle Swarm Optimisation

Md. Alamgir Hossain, Ripon Kumar Chakrabortty, Michael Ryan, Hemanshu Roy Pota

Subject: Engineering, Electrical And Electronic Engineering Keywords: Energy management schemes; particle swarm optimisation; community microgrids; scheduling battery energy; real-time energy management and renewable energy

Online: 16 June 2020 (09:46:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1876.v1

FXR agonism with bile acid mimetic reduces pre-clinical triple-negative breast cancer burden

Sydney Clarice Joseph, Samson Eugin Simon, Margaret Sue Bohm, Minjeong Kim, Madeline E Pye, Boston William Simmons, Dillon Garen Graves, Stacey Marchelle Thomas-Gooch, Ubaid A Tanveer, Jeremiah Ray Holt, Suriyan Ponnusamy, Laura M Sipe, D. Neil Hayes, Katherine Loree Cook, Ramesh Narayanan, Joseph F Pierre, Liza Makowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nuclear hormone receptor, agonist, bile acid receptor, FXR, TGR5, triple-negative breast cancer, TNBC

Online: 26 January 2024 (11:49:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0674.v1

Breast Cancer Bone Metastasis Lesion Segmentation on Bone Scintigraphy

Yi-You Chen, Po-Nien Yu, Yung-Chi Lai, Te-Chun Hsieh, Da-Chuan Cheng

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: bone metastasis segmentation; Double U-Net; pre-train; negative mining; transfer learning; deep learning

Online: 11 July 2023 (10:18:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1209.v1

Medication Review With Follow-up for End-stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated With Medication. A Systematic Review

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: End-stage renal disease; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 June 2023 (10:13:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1664.v1

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Shanisa Naidoo, Arnold M Zwane, Ahmed Paruk, Timothy Craig Hardcastle

Subject: Medicine And Pharmacology, Surgery Keywords: Soft tissue; necrotizing infection; water borne; vibrio; fungal; aeromonas; debridement; negative pressure wound care

Online: 23 May 2023 (14:43:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0089.v6

Omnidimensional Convex Polytopes

Szymon Łukaszyk, Andrzej Tomski

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular basic convex polytopes; circumscribed and inscribed polytopes; negative dimensions; fractal dimensions; complex dimensions; emergent dimensionality; mathematical physics

Online: 24 February 2023 (15:41:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0094.v3

“Clinician’s Probability Calculator” to Convert Pre-Test to Post-Test Probability of COVID-19, Based on Method Validation from Each Laboratory

Zoe Brooks, Saswati Das, Tom Pliura

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-COV-2; False-Positive; False-Negative; Likelihood Ratio; Probability; Calculator; Interpretation

Online: 3 March 2021 (10:08:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0100.v1

Pressure Distribution during Negative Pressure Wound Therapy of Experimental Abdominal Compartment Syndrome in a Porcine Model

Adrienn Csiszkó, Klaudia Balog, Zoltán Attila Godó, Gyula Juhász, Katalin Pető, Ádám Deák, Mariann Berhés, Norbert Németh, Zsolt Bodnár, Zsolt Szentkereszty

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: intra-abdominal pressure; abdominal compartment syndrome; pressure sensor; negative pressure wound therapy; open abdomen;

Online: 11 January 2018 (09:17:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0077.v1

Are Mobile Live Animal Programs Educationally Beneficial? A Critical Assessment of the Human Learning Component Underlying Traveling Animal Exhibits

Kathryn Sussman

Subject: Social Sciences, Education Keywords: zoo; mobile zoo; mobile animal exhibits; animal display; mobile live animal programs; negative education

Online: 16 June 2017 (05:32:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0148.v1

Life Cycle Assessments in Renewable Energy: Solar and Wind Perspectives

Francisco Portillo, Alfredo Alcayde, Rosa Maria Garcia, Manuel Fernandez-Ros, Jose Antonio Gazquez, Nuria Novas.

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: Life Cycle Assessment; renewable energy; solar energy; wind energy; environmental impact; material assessment

Online: 3 May 2024 (11:22:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0928.v1

Retrofitting of an Existing Cultural Hall into a Net Zero Energy Building

Andreas Constantinides, Martha Katafygiotou, Thomas Dimopoulos, Iosif Kapellakis

Subject: Engineering, Architecture, Building And Construction Keywords: energy efficiency; retrofit; sustainable practices; net-zero energy building (nZEB); energy performance certificate

Online: 19 February 2024 (11:48:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0471.v1

Optimal Design and Analysis of a Hybrid Hydrogen Energy Storage System for an Island-based Renewable Energy Community

Zahir Dehouche, Robert Garner

Subject: Engineering, Energy And Fuel Technology Keywords: Decentralised Energy Systems; Renewable Energy Community; Hydrogen Energy Storage System; Decarbonisation; Cost Optimisation

Online: 7 August 2023 (10:36:37 CEST)

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