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Preprint ARTICLE | doi:10.20944/preprints202309.0131.v1

Forensic Analysis of the 38 Subject Deaths in the 6-Month Interim Report of the Pfizer/BioNTech BNT162b2 mRNA Vaccine Clinical Trial

Corinne Michels, Daniel Perrier, Jeyanthi Kunadhasan, Ed Clark, Joseph Gehrett, Barbara Gehrett, Kim Kwiatek, Sarah Adams, Robert Chandler, Leah Stagno, Tony Damian, Erika Delph, Chris Flowers

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BNT162b2 vaccine; Pfizer/BioNTech; cardiovascular events; COVID-19

Online: 4 September 2023 (08:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0122.v1

Accelerated Reported Battery Capacity Loss in 30 kWh Variants of the Nissan Leaf

Daniel Myall, Dima Ivanov, Walter Larason, Mark Nixon, Henrik Moller

Subject: Engineering, Energy And Fuel Technology Keywords: electric vehicle; Nissan Leaf; lithium-ion battery; capacity loss; battery degradation

Online: 15 March 2018 (07:19:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0271.v1

Clinical Characteristics, Activity Levels and Mental Health Problems in Children with Long COVID: A Survey of 510 Children

Danilo Buonsenso, Ferran Espuny Pujol, Daniel Munblit, Sammie Mcfarland, Frances Simpson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: long covid; children; SARS-CoV-2

Online: 9 March 2021 (12:37:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0302.v1

Focusing on the Unfolded Protein Response and Autophagy Related Pathways to Reposition Common Approved Drugs against COVID-19

Serguei Nabirotchkin, Alex E. Peluffo, Jan Bouaziz, Daniel Cohen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-2019; SARS-CoV-2; 2019-nCoV; repositioning; UPR/Autophagy; real-world evidence; pathways

Online: 20 March 2020 (03:55:55 CET)

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More than 179,000 individuals have fallen ill of the Coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus, which first emerged in China less than four months ago in December 2019. As of today, there exist no approved treatments against COVID-19. Vaccines are being developed, but they will take time, at least one year, to reach the population. Drug repositioning represents a fast track because already approved medicines have been broadly tested through multiple trials. We developed a repositioning strategy that mostly leads to candidates that are commonly used. The advantages are that they will facilitate proof of concept in humans through a “real-world evidence” approach and should be rapidly available to the population. We focus on the established research results that the unfolded protein response (UPR) and autophagy pathways of the host cells are essential to the life cycle of previously known coronaviruses. We performed the relevant bioinformatics analysis to understand and confirm if SARS-CoV-2 may interact with these druggable pathways. Based on these considerations, we prioritized two additional druggable pathways, which are important to the viral life cycle and tightly connected to UPR/autophagy signaling: the mitochondrial permeability transition pores (MPTP) and NLRP-3 inflammasome pathways. These four important pathways are perturbed in most major common diseases and have therefore been targeted by numerous broadly prescribed drugs. We have identified 97 approved drugs that are known to modulate these four identified pathways, and which represent, therefore, interesting repositioning candidates. Although it is indisputable that these drugs should never be used for immediate self-medication against COVID-19, we notice that some of them could also be prescribed to individuals who have COVID-19 comorbidities (e.g., hypertension). It is debated if these comorbidities are linked to the pathology itself (e.g., hypertension) or the drugs used to treat the pathology (e.g., sartans). Therefore, relevant preclinical tests and massive electronic health records (i.e., real-world evidence) must be used to pre-screen them and check the COVID-19 prognosis of individuals taking these drugs.

Preprint ARTICLE | doi:10.20944/preprints201805.0050.v1

The FDA and the State of Chronic Diseases: Cardiovascular, Endocrine, Pulmonary, and Renal Diseases

Mona Fiuzat, Michael P. Gray, Grace Anne Dorney Koppel, Aaron Kowalski, Prabir Roy-Chaudhury, Mary Norine Walsh, Daniel W. Jones, Enid Neptune, Robert Ratner, Melissa West, Brad A. Wong, Robert Califf

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic diseases; cardiovascular; renal; endocrine; diabetes; therapeutic advances; tobacco

Online: 3 May 2018 (05:08:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0042.v1

Validity and Reliability of the Kinovea Program in Obtaining Angular and Distance Dimensions

Albert Puig-Diví, Josep Maria Padullés-Riu, Albert Busquets-Faciaben, Xavier Padullés-Chando, Carles Escalona-Marfil, Daniel Marcos-Ruiz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: free software; human motion; Kinovea; low cost; reliability; validity; video analysis

Online: 9 October 2017 (05:07:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0029.v1

Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Daniel Missailidis, Oana Sanislav, Claire Allan, Sarah Annesley, Paul Fisher

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; mitochondria; Complex V; TORC1; Seahorse respirometry; biomarker; diagnosis; ME/CFS

Online: 3 February 2020 (10:36:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0286.v1

Network Bioinformatics Analysis Provides Insight into Drug Repurposing for COVID-2019

Xu Li, Jinchao Yu, Zhiming Zhang, Jing Ren, Alex E. Peluffo, Wen Zhang, Yujie Zhao, Kaijing Yan, Daniel Cohen, Wenjia Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: COVID-2019; SARS-CoV-2; repurposing; network bioinformatics

Online: 18 March 2020 (08:50:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0111.v1

A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications

Jan-Peter Hauschild, Amelia Corinne Peterson, Erik Couzijn, Eduard Denisov, Denis Chernyshev, Christian Hock, Hamish Stewart, Ralf Hartmer, Dmitry Grinfeld, Christian Thoeing, Bastian Reitemeier, Arne Kreutzmann, Oliver Lange, Wilko Balschun, Aivaras Venckus, Sebastian Kanngiesser, Alexander Kholomeev, Gregor Quiring, Frank Czemper, Eloy Wouters, Michael Belford, Mathias Mueller, Jens Grote, Tabiwang N. Arrey, Julia Kraegenbring, Kerstin Strupat, Siegrun Mohring, Catharina Crone, Alexander Harder, Aaron Robitaille, Aaron Gajadhar, Khatereh Motamed, Yang Liu, Daniel Lopez Ferrer, Nicolaie Eugen Damoc, Angela Criscuolo, Kristina Srzentic, Ed George, Charles Yang, Ioanna Ntai, Amanda Souza, Andreas Wieghaus, Alexander Makarov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Orbitrap mass spectrometry; high resolution; accurate mass

Online: 8 June 2020 (10:17:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0148.v1

Ultrasound-Guided Nerve Hydrodissection for Pain Management: An Updated Review of Anatomy and Techniques

King Hei Stanley Lam, Chen-Yu Hung, Yi-Pin Chiang, Kentaro Onishi, Thomas B. Clark, Dean K Reeves, Su Daniel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: nerve hydrodissection; pain management; ultrasonography; neuropathic pain

Online: 15 January 2020 (12:09:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0043.v3

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

Daniel Missailidis, Sarah Annesley, Claire Allan, Oana Sanislav, Brett Lidbury, Donald Lewis, Paul Fisher

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; mitochondria; Complex V; TORC1; Seahorse respirometry

Online: 3 February 2020 (09:34:29 CET)

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic condition characterized by exacerbation of symptoms after exertion (post-exertional malaise or “PEM”), and by fatigue whose severity and associated requirement for rest are excessive and disproportionate to the fatigue-inducing activity. There is no definitive molecular marker or known underlying pathological mechanism for the condition. Increasing evidence for aberrant energy metabolism suggests a role for mitochondrial dysfunction in ME/CFS. Our objective was therefore to measure mitochondrial function and cellular stress sensing in actively metabolising patient blood cells. We immortalized lymphoblasts isolated from 51 ME/CFS patients diagnosed according to the Canadian Consensus Criteria and an age- and gender-matched control group. Parameters of mitochondrial function and energy stress sensing were assessed by Seahorse extracellular flux analysis, proteomics, and an array of additional biochemical assays. As a proportion of the basal oxygen consumption rate (OCR), the rate of ATP synthesis by Complex V was significantly reduced in ME/CFS lymphoblasts, while significant elevations were observed in Complex I OCR, maximum OCR, spare respiratory capacity, nonmitochondrial OCR and “proton leak” as a proportion of the basal OCR. This was accompanied by a reduction of mitochondrial membrane potential, chronically hyperactivated TOR Complex I stress signalling and upregulated expression of mitochondrial respiratory complexes, fatty acid transporters and enzymes of the β-oxidation and TCA cycles. By contrast, mitochondrial mass and genome copy number, as well as glycolytic rates and steady state ATP levels were unchanged. Our results suggest a model in which ME/CFS lymphoblasts have a Complex V defect accompanied by compensatory upregulation of their respiratory capacity that includes the mitochondrial respiratory complexes, membrane transporters and enzymes involved in fatty acid β-oxidation. This homeostatically returns ATP synthesis and steady state levels to “normal” in the resting cells, but may leave them unable to adequately respond to acute increases in energy demand as the relevant homeostatic pathways are already activated.

Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint OPINION | doi:10.3390/sci2030057

Global Significance of Mangrove Blue Carbon in Climate Change Mitigation (Version 1)

Daniel Alongi

Subject: Environmental And Earth Sciences, Environmental Science Keywords: blue carbon; carbon; carbon stock; carbon sequestration; climate change; CO₂ emissions; mangrove; mitigation

Online: 23 July 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0196.v1

Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Daniel Missailidis, Sarah Annesley, Paul Fisher

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, ME/CFS, diagnosis, metabolism, mitochondria, inflammation, immune system, signaling, gut microbiota.

Online: 16 July 2019 (12:41:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0199.v2

Self-Sampling for HPV Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs

Sarah Gupta, Christina Palmer, Elisabeth M. Bik, Juan P. Cardenas, Harold Nuñez, Laurens Kraal, Sara Bird, Jennie Bowers, Alison Smith, Nathaniel A. Walton, Audrey D. Goddard, Daniel E. Almonacid, Jessica Richman, Zachary S. Apte

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: human papillomavirus; HPV; cervical cancer; cancer screening; self-sampling; vaginal microbiome

Online: 1 December 2017 (07:19:13 CET)

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Working Paper ARTICLE

Modified Full-Face Snorkel Mask as COVID-19 Personal Protective Equipment: Quantitative Results

Kyle Nicholson, Ashley Henke-Adams, Daniel M. Henke, Alexxai V. Kravitz, Hiram A. Gay

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; mask; respirator; coronavirus; 3D Printing; N95; personal protective equipment (PPE)

Online: 11 July 2020 (04:16:17 CEST)

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Preprint ARTICLE | doi:10.3390/sci1020045

Influence of Gravitational Shielding on Time Dilation

Stanley Raj, Sohan Jheeta, Daniel, Arun Krishna, Joseph Pious, Hudson Oliver

Subject: Physical Sciences, Theoretical Physics Keywords: gravitational shielding; Casimir effect; electromagnetic field; gravity

Online: 8 August 2019 (00:00:00 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201801.0220.v1

Maristem - Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications

Loriano Ballarin, Baruch Rinkevich, Kerstin Bartscherer, Artur Burzynski, Sebastien Cambier, Matteo Cammarata, Isabelle Domart-Coulon, Damjana Drobne, Juanma Encinas, Uri Frank, Anne-Marie Geneviere, Bert Hobmayer, Helike Löhelaid, Daniel Lyons, Pedro Martinez, Paola Oliveri, Lorena Peric, Stefano Piraino, Andreja Ramšak, Sebastian Rakers, Fabian Rentzsch, Amalia Rosner, Tiago Henriques da Silva, Ildiko Somorjai, Sherif Suleiman, Ana Varela Coelho

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: aging; bioactive molecules; blue biotechnology; cancer; cell culture; COST Action; Europe; marine/aquatic invertebrates; regeneration; stem cells

Online: 24 January 2018 (04:14:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0025.v1

Broad Band Observations Of Gravitationally Lensed Blazar QSO B0218+357 During A Gamma-Ray Outburst

Julian Sitarek, Josefa Becerra González, Sara Buson, Dijana Dominis Prester, Marina Manganaro, Daniel Mazin, Kari Nilsson, Mireia Nievas, Antonio Stamerra, Fabrizio Tavecchio, Ievgen Vovk

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Gamma rays: galaxies; Gravitational lensing: strong; Galaxies: jets; Radiation mechanisms: non-thermal; Galaxies: individual: QSO B0218+357

Online: 13 July 2016 (05:36:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0714.v1

Towards a Biomanufactory on Mars

Aaron Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew McNulty, George Makrygiorgos, Nils J.H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Desiree Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Meraz, Vince Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert W. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Amor A. Menezes, Lance C. Seefeldt, Douglas S. Clark, Adam P. Arkin

Subject: Engineering, Automotive Engineering Keywords: space systems bioengineering; human exploration; mars; in situ resource utilization; life support systems; biomanufacturing

Online: 29 December 2020 (07:57:37 CET)

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Working Paper COMMUNICATION

Sars-Cov-2 Wastewater Surveillance for Public Health Action: Connecting Perspectives From Wastewater Researchers and Public Health Officials During a Global Pandemic

Jill McClary-Gutierrez, Mia Mattioli, Perrine Marcenac, Andrea Silverman, Alexandria Boehm, Kyle Bibby, Michael Balliet, Francis de los Reyes III, Daniel Gerrity, John Griffith, Patricia Holden, Dimitrios Katehis, Greg Kester, Nathan LaCross, Erin Lipp, Jonathan Meiman, Rachel Noble, Dominique Brossard, Sandra McLellan

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: SARS-CoV-2; wastewater surveillance

Online: 7 June 2021 (13:01:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints201707.0045.v1

Fighting Cancer with Mathematics and Viruses

Daniel N. Santiago, Johannes P. W. Heidbuechel, Wendy M. Kandell, Rachel Walker, Christine E. Engeland, Daniel Abate-Daga, Heiko Enderling

Subject: Biology And Life Sciences, Virology Keywords: oncolytic virotherapy; combination therapy; mathematical model; immune system; cancer; immunotherapy

Online: 17 July 2017 (13:01:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0199.v1

Revealing SARS-CoV-2 Functional Druggability Through Multi-Target Cadd Screening of Repurposable Drugs

Yash Gupta, Dawid Maciorowski, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Ajay Bharti, Daniel Becker, Rathi Brijesh, Steven B Bradfute, Ravi Durvasula, Prakasha Kempaiah

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: SARS-CoV-2; COVID-19; CADD; virtual screening; approved drugs; drug repurposing; essential targets; molecular docking; molecular dynamics simulations

Online: 11 May 2020 (13:14:18 CEST)

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The emergence of SARS/MERS drug resistant COVID-19 with high transmission and mortality has recently been declared a deadly pandemic causing economic chaos and significant health problems. Like all coronaviruses, SARS-CoV-2 is a large virus that has many druggable components within its proteome. In this study, we focused on repurposing approved and investigational drugs by identifying potential drugs that are predicted to effectively inhibit critical enzymes within SARS-CoV-2. We shortlisted seven target proteins with enzymatic activities known to be essential at different stages of the virus life cycle. For virtual screening, the energy minimization of a crystal structure or modeled protein was carried out using Protein Preparation Wizard (Schrödinger LLC, 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs (n=5903) that are already approved by worldwide regulatory bodies including the FDA, using the ZINC database. Screening was performed against viral targets using three sequential docking modes (i.e. HTVS, SP and XP). Our in-silico virtual screening identified ~290 potential drugs based on the criteria of energy, docking parameters, ligand and binding site strain and score. Drugs specific to each target protein were further analyzed for binding free energy perturbation by molecular mechanics (prime MM-GBSA) and pruning the hits to the top 32 candidates. A top lead from each target group was further subjected to molecular dynamics simulation (MDS) using the Desmond module to validate the efficacy of the screening pipeline. All of the simulated hit-target complexes were predicted to strongly interact and with highly stable binding. Thus, we have identified a number of approved and investigational drugs with high likelihood of inhibiting a variety of key SARS-CoV-2 proteins. Follow-up studies will continue to identify inhibitors suitable for combination therapy based on drug-drug synergy to thwart resistance. In addition, the screening hits that we have identified provide excellent probes for understanding the binding properties of the active sites of all seven targets, further enabling us to derive consensus molecules through computer-aided drug design (CADD). While infections are expanding at a rampant pace, it must be recognized that resistance will grow commensurately through either genetic shift and/or genetic drift to all small molecule drugs identified. Vaccines should provide a more permanent solution through prevention, but resistivity is still a possible scenario. Nevertheless, a persistent multi-target drug development program is essential to curb this ongoing pandemic and to keep reemergence in check.

Preprint ARTICLE | doi:10.20944/preprints201611.0048.v2

Uridine Triphosphate Thio-analogues Inhibit Platelet P2Y₁₂ Receptors and Aggregation

Dursun Guenduez, Christian Tanislav, Daniel Sedding, Mariana Parahuleva, Sentot Santoso, Christian Troidl, Christian Hamm, Muhammad Aslam

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: 2S-UTP; 4S-UTP; P2Y12 receptors; ADP; platelet aggregation

Online: 28 December 2016 (10:46:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0478.v1

Risk Assessment of SARS-CoV-2 in Antarctic Wildlife

Andrés Barbosa, Arvind Vansani, Virginia Morandini, Wray Grimaldi, Ralph E.T. Vanstreels, Julia I. Diaz, Thierry Boulinier, Meagan Dewar, Daniel Gonzalez-Acuña, Rachel Gray, Clive R. McMahon, Gary Miller, Michelle Power, Amandine Gamble, Michelle Wille

Subject: Biology And Life Sciences, Virology Keywords: Antarctica; coronavirus; COVID-19; mitigation measures; reverse zoonoses; risk assessment; SARS-CoV-2; wildlife

Online: 21 August 2020 (09:21:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201802.0134.v1

Arbidol (Umifenovir): A Broad-spectrum Antiviral Drug that Inhibits Medically Important Arthropod-borne Flaviviruses

Jan Haviernik, Michal Stefanik, Martina Fojtikova, Sabrina Kali, Noël Tordo, Ivo Rudolf, Zdenek Hubalek, Ludek Eyer, Daniel Ruzek

Subject: Biology And Life Sciences, Virology Keywords: flavivirus; arbidol; umifenovir; antiviral activity; cytotoxicity; cell-type dependent antiviral effect

Online: 21 February 2018 (14:44:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0239.v1

Synthesis and Characterization of Dibutyltin Compounds with α-Amino Acids

Roberto Santos Barbiéri, Vilma Reis Terra, Allan Kardec Carlos Dias, Walclée De Carvalho Melo, Daniel Rodrigues Silva

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: organotin compounds; dibutyltin compounds; tin α-amino acids compounds; thermal decomposition

Online: 31 August 2016 (10:43:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0268.v1

Candles from Soybean Seed Oil Extract

Modupe Ojewumi, Basil Ruth, Oyekunle Daniel

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Soybeans, Soxhlet extraction, Oil extract, solvent, Yield

Online: 26 August 2019 (13:54:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0097.v2

Natural Pathogen Inhibiting Chemistry to Replace Toxic Treatment of Microbes and Biofilm in Cooling Towers ^†

Lon Brouse, Richard Brouse, Daniel Brouse

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pathogens; Legionella; amoeba; protozoa; biofilm; antibacterial; antimicrobial; cooling towers; biocides; polyvalent metals

Online: 20 December 2016 (10:26:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0153.v1

A Hitchhiker’s Guide to Working with Large, Open-Source Neuroimaging Datasets

Corey Horien, Stephanie Noble, Abigail Greene, Kangjoo Lee, Daniel Barron, Siyuan Gao, Dave O'Connor, Mehraveh Salehi, Javid Dadashkarimi, Xilin Shen, Evelyn Lake, R. Todd Constable, Dustin Scheinost

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Open-science; big data; fMRI; data sharing; data management

Online: 8 July 2020 (11:53:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0050.v1

On a Long Term Strategy for the Success of Nuclear Power

Bruno Merk, Dzianis Litskevich, Karl R. Whittle, Mark Bankhead, Richard Taylor, Daniel Mathers

Subject: Engineering, Energy And Fuel Technology Keywords: nuclear; reactor; spent fuel; P&T; innovation strategy; molten salt reactor

Online: 10 April 2017 (06:20:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0054.v1

Critical Issues in Modelling Lymph Node Physiology

Dmitry Grebennikov, Raoul van Loon, Mario Novkovic, Lucas Onder, Rostislav Savinkov, Igor Sazonov, Rufina Tretyakova, Daniel J. Watson, Gennady Bocharov

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: computational model; lymph node; multiscale structure; vascular network; fibroblastic reticular cells; conduit network; lymph flow; destruction of conduits

Online: 9 December 2016 (10:19:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0552.v1

Role of Information Technology in COVID19 Vaccination Drive: An Analysis of the COVID-19 Global Beliefs, Behaviors, and Norms Survey

Debjyoti Talukdar, Kire Stojkovski, Daniel Suarez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID19; vaccine; SARS nCoV-2; information technology; COVID19 vaccine survey; MIT vaccine survey

Online: 20 April 2021 (14:35:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0148.v1

Information Theoretic Source Seeking Strategies for Multiagent Plume Tracking in Turbulent Fields

Hadi Hajieghrary, Daniel C. Mox, M. Ani Hsieh

Subject: Engineering, Control And Systems Engineering Keywords: multi-agent systems; information theory; distributed control; value of information; collaborative search

Online: 29 November 2016 (07:20:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0500.v1

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Mohammad Mukarram, Sadaf Choudhary, Mo Ahamad Khan, Palmiro Poltronieri, M. Masroor A. Khan, Jamin Ali, Daniel Kurjak, Mohd Shahid

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: anticancer; antimicrobial; antioxidants; cancer signalling; citral; Cymbopogon; essential oil

Online: 21 June 2021 (10:31:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0119.v1

Implementation of Regional-CNN and SSD Machine Learning Object Detection Architectures for the Real Time Analysis of Blood Borne Pathogens in Dark Field Microscopy

Daniel Fleury, Angelica Fleury

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Convolutional Neural Network,Single Shot Detector, Regional Convolutional Neural Network, Machine Learning, Visualization-Localization

Online: 6 July 2018 (14:38:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0058.v1

Towards Engineering Biosystems with Emergent Collective Functions

Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T-Y. Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O. R. Dixon, Alex J. H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: synthetic biology; multi-agent modelling; individual-based modelling; agent-based modelling; systems biology; emergence; multi-scale; bioengineering; consortia; collectives

Online: 5 May 2020 (03:45:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0452.v1

Virtual Reality Tremor Reduction in Parkinson's Disease

John Cornacchioli, Alec Galambos, Stamatina Rentouli, Robert Canciello, Roberta Marongiu, Daniel Cabrera, eMalick G. Njie

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurodegeneration; Parkinson's disease; essential tremor; Deep Brain stimulation; Levodopa; Virtual Reality; Oculus Rift; Medical Virtual Reality; Tremor stabilization; Equalizers

Online: 29 February 2020 (03:56:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0492.v2

COVID-19 Pandemic in Nigeria: Misconception Among Individuals, Impact on Animals and the Role of Mathematical Epidemiologists

Oluwasegun Micheal Ibrahim, Damilola Daniel Ekundayo

Subject: Social Sciences, Psychology Keywords: COVID-19; pandemic; misconception; mathematical modeling; infectious disease; Nigeria

Online: 20 January 2021 (14:11:38 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202103.0194.v1

scikit-activeml: A Library and Toolbox for Active Learning Algorithms

Daniel Kottke, Marek Herde, Tuan Pham Minh, Alexander Benz, Pascal Mergard, Atal Roghman, Christoph Sandrock, Bernhard Sick

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Active Learning, Classification, Machine Learning, Python, Github, Repository, Open Source

Online: 5 March 2021 (21:14:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0591.v1

Neuromuscular Adverse Events Associated with Anti-PD-1 Monoclonal Antibodies: Systematic Review

Annette Johansen, Søren Just Christensen, David Scheie, Joan L. S. Højgaard, Daniel Kondziella

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: adverse events; immune checkpoint inhibitor; myasthenia gravis; myopathy; neuropathy; nivolumab; pembrolizumab

Online: 29 September 2018 (11:28:00 CEST)

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Working Paper COMMUNICATION

Social Values Are Significant Factors in Control of COVID-19 Pandemic – Preliminary Results

Andrzej Jarynowski, Monika Wójta-Kempa, Daniel Płatek, Vitaly Belik

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; social values; cross-cultural studies

Online: 3 May 2020 (08:24:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0171.v1

Specific and Complete Local Integration of Patterns in Bayesian Networks

Martin Biehl, Takashi Ikegami, Daniel Polani

Subject: Computer Science And Mathematics, Mathematics Keywords: identity over time; Bayesian networks; multi-information; entity; persistence; integration; emergence; naturalising agency

Online: 21 March 2017 (16:23:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0267.v2

Systematic Review of Wastewater Surveillance of Antimicrobial Resistance in Human Populations

Kevin Chau, Leanne Barker, Eric Budgell, Karina-doris Vihta, Natalie Sims, Barbara Kasprzyk-Hordern, Elinor Harriss, Derrick Crook, Daniel Read, Sarah Walker, Nicole Stoesser

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: AMR; sewage; epidemiology; wastewater; surveillance

Online: 21 June 2021 (11:25:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0469.v1

Caffeine as Nitrogen Source for Reduce Graphene Doping, and Its Functionalization with Silver Nanowires

Daniel Ramirez-Gonzalez, Jose de Jesus Cruz-Rivera, Hugo Tiznado, Angel Gabriel Rodriguez-Vazquez, Ivan Guillen-Escamilla, Adalberto Zamudio-Ojeda

Subject: Chemistry And Materials Science, Nanotechnology Keywords: caffeine; nitrogen-doping; graphene; nanowires; functionalization; pyridinic; monolayer; synthesis; carbon nanostructures; nanomaterials

Online: 25 July 2018 (06:10:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0051.v2

Exploring the Glycans of Euglena gracilis

Ellis C. O'Neill, Sakonwan Kuhaudomlarp, Martin Rejzek, Jonatan U. Fangel, Kathirvel Alagesan, Daniel Kolarich, William G. T. Willats, Robert A. Field

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: algae; Euglena; biotechnology; carbohydrates; N-glycan; sugar nucleotide

Online: 17 December 2017 (08:55:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0013.v1

Interannual Variability and Seasonal Predictability of Wind and Solar Resources

Nir Y. Krakauer, Daniel S. Cohan

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: renewable energy; solar; wind; interannual variability; seasonal forecasting; teleconnections

Online: 7 July 2017 (03:55:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0122.v1

Ten Simple Rules for Open Health Research

Aïda Bafeta, Jason Bobe, Jon Clucas, Pattie Pramila Gonsalves, Célya Gruson-Daniel, Kathy Hudson, Arno Klein, Anirudh Krishnakumar, Anna McCollister-Slipp, Ariel Lindner, Dusan Misevic, John Naslund, Camille Nebeker, Aki Nikolaidis, Irene Pasquetto, Gabriela Sanchez, Matthieu Schapira, Tohar Scheininger, Félix Schoeller, Anibal Sólon, François Taddei

Subject: Medicine And Pharmacology, Other Keywords: open health; simple rules; ethics; reproducibility; research significance; open science

Online: 11 September 2019 (13:27:26 CEST)

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We are witnessing a dramatic transformation in the way we do science. In recent years, significant flaws with existing scientific methods have come to light, including lack of transparency, insufficient involvement of stakeholders, disconnection from the public, and limited reproducibility of research findings. These concerns have sparked a global movement to revolutionize scientific practice and the emergence of Open Science. This new approach to science extends principles of openness to the entire research cycle, from hypothesis generation to data collection, analysis, replication, and translation from research to practice. Open Science seeks to remove all barriers to conducting high quality, rigorous, and impactful scientific research by ensuring that the data, methods, and opportunities for collaboration are open to all. Emerging digital technologies and "big data" (see "Ten simple rules for responsible big data research") have further accelerated the Open Science movement by affording new approaches to data sharing, connecting researcher networks, and facilitating the dissemination of research findings. Open scientific practices are also having a profound impact on the health sciences and medical research, and specifically how we conduct clinical research with human participants. Human health research necessitates careful considerations for practicing science in an ethical manner. There is also a particular urgency to human health research since the goal is to help people, so doing good science takes on a different meaning than simply doing science well. It also implores the scientist to reassess the conventional view of human health research as a pursuit conducted by scientists on human subjects, and lays a greater emphasis on inclusive and ethical practices to ensure that the research takes into account the interests of those who would be most impacted by the research. Openness in the context of human health research also raises greater concerns about privacy and security and presents more opportunities for people, including participants of research studies, to contribute in every capacity. At the core of open health research, scientific discoveries are not only the product of collaboration across disciplines, but must also be owned by the community that is inclusive of researchers, health workers, and patients and their families. To guide successful open health research practices, it is essential to carefully consider and delineate its guiding principles. This editorial is aimed at individuals participating in health science in any capacity, including but not limited to people living with medical conditions, health professionals, study participants, and researchers spanning all types of disciplines. We present ten simple rules that, while not comprehensive, offer guidance for conducting health research with human participants in an open, ethical, and rigorous manner. These rules can be difficult, resource-intensive, and can conflict with one another. They are aspirational and are intended to accelerate and improve the quality of human health research. Work that fails to follow these rules is not necessarily an indication of poor quality research, especially if the reasons for breaking the rules are considered and articulated (see rule 6: document everything). While most of the responsibility of following these rules falls on researchers, anyone involved in human health research in any capacity can apply them.

Preprint ARTICLE | doi:10.20944/preprints201708.0024.v1

Sub-Chronic Toxicity Study of Hydroethanolic Leaf Extract of Telfairia Occidentalis Hook. F. (Cucurbitaceae) in Rats

Abidemi J. Akindele, Joy A. Oladimeji-Salami, Ramon A. Oyetola, Daniel D. Osiagwu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Telfairia occidentalis; Cucurbitaceae; subchronic; toxicity; biochemical; haematological

Online: 7 August 2017 (16:00:43 CEST)

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Background: The leaf of Telfairia occidentalis Hook f. (Cucurbitaceae) is consumed in different parts of Nigeria because of the numerous nutritional and medicinal attributes ascribed to it. The sub-chronic toxicity of the hydroethanolic leaf extract of Telfairia occidentalis (TO) was investigated in this study. Methods: Rats in different groups were separately administered 80, 400 and 2000 mg/kg TO p.o. for 60 days. Animals were sacrificed and blood samples collected for haematological and biochemical analysis. Vital organs were harvested and evaluated for in vivo antioxidants and histopathological changes. Results: Results showed no significant changes in the weight of vital organs except in respect of the testes of the group treated with 2000 mg/kg extract which showed a significant (p<0.05) reduction in weight compared to the control group. There was a significant (p<0.01) increase in sperm motility and count of the group administered 80 mg/kg extract and a significant (p<0.001) reduction was observed at 2000 mg/kg. There were significant increases in the level of Hb and PCV at 80 and 2000 mg/kg of the extract. In respect of liver function parameters, a significant decrease in AST and ALT levels at doses of 400 and 2000 mg/kg relative to control was observed. A significant reduction (p<0.05) in the level of total cholesterol (400 mg/kg) and increase (p<0.05) in level of HDL (80-2000 mg/kg) compared to control was observed. There was also significant (p<0.05) increase in the level of MDA and significant (p<0.05) decrease in SOD level in the testes at 2000 mg/kg. Histopathological assessment of the testes revealed abnormality at this dose. These effects were reversed after 30 days of cessation of administration of TO. Conclusions: The findings showed that the hydroethanolic leaf extract of Telfairia occidentalis is relatively non-toxic on acute and sub-chronic exposure, with potential to elicit anti-anaemic effect, reduce the risk of atherosclerosis and cardiovascular disease, and enhance antioxidant status in the brain and liver. Although possibly beneficial at low dose, the extract could be harmful to the testes on prolonged oral exposure at high dose.

Preprint ARTICLE | doi:10.20944/preprints202007.0336.v3

Factors Influencing Genomic Prediction Accuracies of Tropical Maize Resistance to Fall Armyworm and Weevils

Arfang Badji, Lewis Machida, Daniel Bomet Kwemoi, Frank Kumi, Dennis Okii, Natasha Mwila, Symphorien Agbahoungba, Angele Ibanda, Astere Bararyenya, Selma Ndapewa Nghituwamhata, Thomas Odong, Peter Wasswa, Mildred Ochwo-Ssemakula, Herbert Talwana, Godfrey Asea, Michael Otim, Samuel Kyamanywa, Patrick Rubaihayo

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Prediction accuracy; Mixed linear and Bayesian models; Machine Learning algorithms; Training set size and composition; Parametric and nonparametric models

Online: 17 September 2020 (05:41:51 CEST)

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Working Paper COMMUNICATION

Open Questions for Harnessing Autophagy-Modulating Drugs in the SARS-CoV-2 War: Hope or Hype?

Patrick Brest, Jonathan Benzaquen, Daniel J. Klionsky, Paul Hofman, Baharia Mograbi

Subject: Biology And Life Sciences, Virology Keywords: anti-viral; COVID-19; SARS-CoV-2; autophagy; chloroquine; hydroxychloroquine; immunology; infection; inflammation; lysophagy; microbiology; Plaquenil; SARS; virophagy

Online: 23 May 2020 (10:45:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0065.v1

Solar PV Cost Reduction Potential in Japan

Robert Höller, Daniel Gudopp, Tobias Leschinsky

Subject: Engineering, Energy And Fuel Technology Keywords: Solar PV; cost reduction; balance of system; Japan

Online: 5 April 2019 (12:10:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0079.v1

Cryptic Species Diversity of Rice Hopper Parasitoids in Southeast Asia

Christina Sann, Franziska Wemheuer, Alexis Beaurepaire, Rolf Daniel, silvio Erler, Stefan Vidal

Subject: Biology And Life Sciences, Insect Science Keywords: DNA barcoding; genetic diversity; hymenopteran parasitoids; Nephotettix spp.; Nilaparvata lugens; rice

Online: 13 November 2017 (17:06:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0032.v1

Impact of Volcanic Ash on Road and Airfield Surface Skid Resistance

Daniel M. Blake, Thomas M. Wilson, Jim W. Cole, Natalia I. Deligne, Jan M. Lindsay

Subject: Environmental And Earth Sciences, Environmental Science Keywords: asphalt; concrete; runway; highway; traction; British Pendulum Tester; safety

Online: 14 July 2017 (10:11:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0406.v1

Teaching Anxiety, Stress and Resilience during the COVID-19 Pandemic: Evaluating the Vulnerability of Academic Professionals in Mexico through the Adapted COVID-19 Stress Scales

Juan Luis Delgado-Gallegos, Gerardo R. Padilla-Rivas, Erika Zuñiga-Violante, Gener Avilez-Rodriguez, Daniel Arrellanos Soto, Hector Franco-Villareal, María de los Angeles Cosio-León, Gerardo Salvador Romo-Cardenas, Jose Francisco Islas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Adapted COVID-Stress Scales; Stress in Academic Professionals; Resilience to COVID stress in Academia

Online: 20 January 2021 (16:37:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0056.v1

Conditioning Factors in the Transition Process to the Self-Care of Women with AIDS

Claudia Regina de Andrade Arrais Rosa, Simony Fabíola Lopes Nunes, Regiane Silva de Jesus, Francisco Dimitre Rodrigo Pereira Santos, Leila Rute Oliveira Gurgel do Amaral, Nilviane Pires Silva Sousa, Daniel Costa Duarte, Allan Kardec Barros Duailibe Filho

Subject: Social Sciences, Psychology Keywords: nursing theory; self-care women; HIV

Online: 10 October 2017 (02:55:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0199.v1

Improving Quantitative Rainfall Prediction Using Ensemble Analogues in the Tropics: Case study of Uganda

Isaac Mugume, Michel d. S. Mesquita, Yazidhi Bamutaze, Didier Ntwali, Charles Basalirwa, Daniel Waiswa, Joachim Reuder, Revocatus Twinomuhangi, Fredrick Tumwine, Triphonia Jakob Ngailo, Bob Alex Ogwang

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Ensemble mean; Analogue ensemble mean; Multi–member analogue ensemble mean; Quantitative rainfall prediction

Online: 31 October 2017 (16:28:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0435.v1

Lifestyle Habits and Mental Health in Light of the Two COVID-19 Pandemic Waves in Sweden, 2020

Victoria Blom, Amanda Lonn, Björn Ekblom, Lena.V. Kallings, Daniel Väisänen, Erik Hemmingsson, Gunnar Andersson, Peter Wallin, Andreas Stenling, Örjan Ekblom, Magnus Lindwall, Jane Salier Eriksson, Tobias Holmlund, Elin Ekblom-Bak

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Physical activity; Sitting; Alcohol; Diet; Smoking; SARS-CoV-2; Sweden; Mental health; Health anxiety; Depression

Online: 19 February 2021 (10:07:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0061.v1

Generalized Triangular Intuitionistic Fuzzy Geometric Averaging Operator for Decision Making in Engineering

Daniel O. Aikhuele, Sarah Odofin

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: generalized triangular intuitionistic fuzzy geometric aggregation operator; triangular intuitionistic fuzzy number; intuitionistic fuzzy set; multi-criteria decision-making; attitudinal character; flexibility

Online: 14 June 2017 (05:55:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0364.v1

Seed Priming Technology as a Key Strategy to Increase Crop Plant Production under Adverse Environmental Conditions

Daniel Garcia, Samiah Arif, Yinglei Zhao, Shuo Zhao, Lin Chau Ming, Danfeng Huang

Subject: Biology And Life Sciences, Horticulture Keywords: stress tolerance; biological mechanisms; biotic/Abiotic stress; hybrid priming; high-quality seeds

Online: 21 September 2021 (14:02:07 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202011.0556.v1

Resilience Against the Covid-19 Pandemic among Indigenous Kichwa Communities in Ecuadorian Amazonia

Anders Sirén, Michael Uzendoski, Tod Swanson, Iván Jácome-Negrete, Emil Sirén-Gualinga, Andrés Tapia, Alex Dahua-Machoa, Aymé Tanguila, Eugenia Santi, Dionicio Machoa, Dixon Andi, Daniel Santi

Subject: Biology And Life Sciences, Plant Sciences Keywords: Covid-19; indigenous people; Amazon; medicinal plants; vulnerability; resilience

Online: 22 November 2020 (11:40:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0361.v1

Socio-Economic Factors Influencing Use and Adoption of Family-Sized Bio-digesters as Renewable Energy Sources in Ngoma District, Rwanda

Danson Musinguzi, Emmanuel Kayinamura, Anne Tumushabe, Daniel Omuna, Emmaniel Innocent Eniru, Oluwole Olusegun Akiyode, Hadijjah Katongole, Edson Mwebesa, Twaha Ali Basamba, Dominic Byarugaba

Subject: Engineering, Energy And Fuel Technology Keywords: bio-digesters; household income levels; renewable energy; socio-economic

Online: 25 May 2018 (10:55:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0045.v1

Socioeconomic Indicators of Bamboo Use for Agroforestry Development in the Dry Semi-Deciduous Forest Zone of Ghana

Daniel S. Akoto, Manfred Denich, Samuel T. Partey, Frith Oliver, Michael Kwaku, Alex A. Mensah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: adoption; land-use; degradation; ethnobotany; networking; agroforestry; dry semi-deciduous

Online: 7 November 2017 (04:06:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0042.v1

Organic Food Products Labeling Innovation: The Case for Sustainable Food Consumption Behavior

Daniel Adrian Gârdan, Ionel Dumitru, Ilić Dragan, Iuliana Petronela Gârdan, Mihai Andronie, Cristian Uță

Subject: Business, Economics And Management, Marketing Keywords: products labeling; organic food products labeling; labeling innovation; sustainable food consumption; buying decision

Online: 2 May 2018 (13:10:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1770.v1

Shared Protentions in Multi-Agent Active Inference

Mahault Albarracin, Riddhi Jain Pitliya, Toby Benedict St. Clere Smithe, Daniel Ari Friedman, Karl Friston, Maxwell J. D. Ramstead

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: active inference; phenomenology; multi-agent; category theory

Online: 26 December 2023 (01:31:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0001.v1

Agnoprotein is an Essential Egress Factor during BK Polyomavirus Infection

Margarita Maria-Panou, Emma L. Prescott, Daniel L. Hurdiss, Gemma Swinscoe, Michael Hollinshead, Laura G. Caller, Ethan L. Morgan, Louisa Carlisle, Marietta Muller, Michelle Antoni, David Kealy, Neil A. Ranson, Colin M. Crump, Andrew Macdonald

Subject: Biology And Life Sciences, Virology Keywords: polyomavirus; agnoprotein; virus exit

Online: 1 March 2018 (04:11:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0124.v1

Data-driven Analytical Models of COVID-2019 for Epidemic Prediction, Clinical Diagnosis, Policy Effectiveness and Contact Tracing: A Survey

Ying Mao, Susiyan Jiang, Daniel Nametz

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; Epidemic Prediction; Clinical Diagnosis; Policy Effectiveness; Contact Tracing

Online: 7 July 2020 (10:06:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0249.v1

Reinforcement Systems for Carbon Concrete Composites Based on Low-Cost Carbon Fibers

Robert Böhm, Mike Thieme, Daniel Wohlfahrt, Daniel Wolz, Benjamin Richter, Hubert Jäger

Subject: Engineering, Mechanical Engineering Keywords: carbon concrete composites; low-cost carbon fibers; pultrusion

Online: 13 July 2018 (17:51:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0084.v1

Dual Antiplatelet Therapy (DAPT) in Coronary Artery Disease: A Daunting Dilemma

Suryateja Chaturvedula, Daniel J. Diver, Aseem Vashist

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: dual anti platelet therapy; acute coronary syndrome; stents

Online: 12 February 2018 (05:13:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0098.v1

Assembly of the Boechera retrofracta Genome and Evolutionary Analysis of Apomixis-Associated Genes

Sergei Kliver, Mike Rayko, Alexey Komissarov, Evgeny Bakin, Daria Zhernakova, Kasavajhala V. S. K. Prasad, Catherine Rushworth, R. Baskar, Dmitry Smetanin, Jeremy Schmutz, Daniel S. Rokhsar, Thomas Mitchell-Olds, Ueli Grossniklaus, Vladimir Brukhin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Boechera; Brassicaceae; genome; assembly; annotation; apomixis

Online: 14 February 2018 (07:29:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201903.0255.v1

Spatialities of Dog Theft: A Critical Perspective

Daniel Allen, Adam Peacock, Jamie Arathoon

Subject: Social Sciences, Geography, Planning And Development Keywords: dog theft; pet theft; dogs; pets, crime; animal geography; GIS

Online: 28 March 2019 (06:40:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0054.v1

Phosphate Detection in Hydroponics using Molecularly Imprinted Polymer Sensors

Christopher S. Storer, Zachary Coldrick, Daniel Tate, Jack Marsden Donoghue, Bruce Grieve

Subject: Engineering, Electrical And Electronic Engineering Keywords: hydroponics; interdigitated electrodes; molecularly imprinted polymer; nutrient monitoring; phosphate; polymer sensor; precision agriculture

Online: 8 January 2018 (09:22:17 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202108.0428.v1

Tipping Point Towards Biodiversity Conservation? Local and Global Consequences of the Application of ‘Rights of Nature’ by Ecuador

Juan M. Guayasamin, Roo Vandegrift, Tobias Policha, Andrea C. Encalada, Natalia Greene, Blanca Ríos-Touma, Lorena Endara, Rafael E. Cárdenas, Fred Larreátegui, Luis Baquero, Inty Arcos, José Cueva, Mika Peck, Felipe Alfonso-Cortes, Daniel Thomas, José DeCoux, Elisa Levy, Bitty A. Roy

Subject: Social Sciences, Law Keywords: Ecuador; Rights of Nature; Reserva Los Cedros; Conservation; Mining

Online: 23 August 2021 (10:49:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0143.v1

Strain Localization during Equal-Channel Angular Pressing analyzed by Finite Element Simulations

Tobias Daniel Horn, Christian Bert Silbermann, Philipp Frint, Martin Franz-Xaver Wagner, Jörn Ihlemann

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: equal-channel angular pressing; ECAP; shear band; matrix band; kinematic hardening; FEM; strain localization

Online: 20 December 2017 (10:01:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0250.v2

From Understanding to Sustainable Use of Peatlands: The WETSCAPES Approach

Gerald Jurasinski, Sate Ahmad, Alba Anadon-Rosell, Jacqueline Berendt, Florian Beyer, Ralf Bill, Gesche Blume-Werry, John Couwenberg, Anke Günther, Hans Joosten, Franziska Koebsch, Daniel Köhn, Nils Koldrack, Jürgen Kreyling, Peter Leinweber, Bernd Lennartz, Haojie Liu, Dierk Michaelis, Almut Mrotzek, Wakene Negassa, Sandra Schenk, Franziska Schmacka, Sarah Schwieger, Marko Smiljanic, Franziska Tanneberger, Laurenz Teuber, Tim Urich, Haitao Wang, Micha Weil, Martin Wilmking, Dominik Zak, Nicole Wrage-Mönnig

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: fen; paludiculture; rewetting; drainage; matter fluxes; interdisciplinary

Online: 29 February 2020 (10:44:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0138.v2

A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy

Wesley A. Williams, Ashley J. Denslow, Peter W. Radulovic, Daniel J. Denmark, Shyam S. Mohapatra

Subject: Chemistry And Materials Science, Nanotechnology Keywords: inorganic nanoparticles; in silico; optimization; theranostic; therapeutic; diagnostic; computation; coding; Python

Online: 7 September 2021 (11:57:23 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202003.0430.v1

Safety Recommendations for Evaluation and Surgery of the Head and Neck during the COVID-19 Pandemic

Babak Givi, Bradley A. Schiff, Steven B. Chinn, Daniel Clayburgh, N. Gopalkrishna Iyer, Scharukh Jalisi, Michael G. Moore, Cherie-Ann Nathan, Lisa A. Orloff, James P. O'Neill, Noah Parker, Chad Zender, Luc G.T. Morris, Louise Davies

Subject: Medicine And Pharmacology, Otolaryngology Keywords: COVID-19; tracheostomy; head and neck; otolaryngology

Online: 29 March 2020 (09:15:12 CEST)

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Importance: The rapidly expanding 2019 novel coronavirus pandemic (COVID-19, caused by the SARS-CoV-2 virus) has challenged the medical community to an unprecedented degree. Physicians and healthcare workers are at added risk of exposure and infection during the course of the patient care. Due to the rapid spread of this disease through respiratory droplets, healthcare providers such as otolaryngologists-head & neck surgeons who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures are particularly at risk. Here we present a set of safety recommendations based on our review of literature and communications with physicians with first-hand knowledge of safety procedures during the 2019 COVID-19 pandemic.Observations: A high number of healthcare providers were infected during the first phase of the pandemic in Wuhan province. Subsequently, by adopting strict safety precautions, other regions were able to achieve high levels of safety for healthcare providers without jeopardizing the care of patients. We reviewed the most common procedures related to the examination and treatment of upper aerodigestive tract diseases. Each category was reviewed based on the potential risk imposed to healthcare workers. Specific recommendations were made, based on the literature, when available, or consensus best practices. Specific safety recommendations were made for performing tracheostomy in COVID-19 patients. Conclusions and Relevance: Preserving highly skilled healthcare work force is a top priority for any community and healthcare system. Based on the experience of healthcare systems in Asia and Europe, by following strict safety guidelines, the risk of exposure and infection of healthcare providers could be significantly reduced, while providing high levels of care. The provided recommendations could be used as broad guidance for all healthcare workers who are involved with the care of COVID-19 patients.

Preprint REVIEW | doi:10.20944/preprints202106.0489.v1

Neurotherapeutics for Attention Deficit Hyperactivity Disorder (ADHD): a Review

Katya Rubia, Samuel Westwood, Pascal-M. Aggensteiner, Daniel Brandeis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Attention Deficit Hyperactivity Disorder (ADHD); functional magnetic resonance imaging (fMRI); Neurofeedback; EEG-Neurofeedback; fMRI-Neurofeedback; brain stimulation; transcranial magnetic stimulation (TMS); transcranial direct current stimulation (tDCS); trigeminal nerve stimulation (TNS).

Online: 18 June 2021 (15:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0130.v1

Organochlorine Pesticides in Honey and Pollen Samples from Managed Colonies of the Honey Bee Apis mellifera Linnaeus and the Stingless Bee Scaptotrigona mexicana Guérin from Southern, Mexico

Jovani Ruiz-Toledo, Rémy Vandame, Ricardo A. Castro-Chan, Rosa P. Penilla-Navarro, Jaime Gómez, Daniel Sánchez

Subject: Biology And Life Sciences, Insect Science Keywords: pesticides; native bee; persistency; biomonitoring

Online: 16 March 2018 (06:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0227.v1

Rewetting of Three Drained Peatlands Drives Congruent Compositional Changes in Pro- and Eukaryotic Soil Microbiomes through Environmental Filtering

Micha Weil, Haitao Wang, Mia Bengtsson, Daniel Köhn, Anke Günther, Gerald Jurasinski, John Couwenberg, Wakene Negassa, Dominik Zak, Tim Urich

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: peatland management; microbiome; methanogens; dissolved organic matter; Methylococcaceae; sulfate

Online: 16 February 2020 (16:22:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0655.v1

Computational Determination of Macroscopic Mechanical and Thermal Material Properties for Different Microstructural Variants of Cast Iron

Christoph Herrmann, Stefan Schmid, Daniel Schneider, Michael Selzer, Britta Nestler

Subject: Chemistry And Materials Science, Biomaterials Keywords: cast iron with lamellar graphite; graphite microstructure; mechanical properties; thermal properties; material properties; microstructure simulations; homogenization; material data workflow

Online: 29 July 2021 (12:33:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0096.v1

Multifractal Comparison of Reflectivity and Polarimetric Rainfall Data from C- and X-Band Radars and Respective Hydrological Responses of a Complex Catchment Model

Igor Paz, Bernard Willinger, Auguste Gires, Laurent Monier, Christophe Zobrist, Bruno Tisserand, Ioulia Tchiguirinskaia, Daniel Schertzer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: complex catchment; weather X-band radars; flash floods; multifractals; spatio-temporal variability

Online: 14 October 2017 (03:10:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0658.v1

Profiling of Matched Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways

Ashok Narasimhan, Xiaoling Zhong, Ernie Au, Eugene P. Ceppa, Atilla Nakeeb, Michael G. House, Nicholas J. Zyromski, C. Max Schmidt, Katharyn N.H. Schloss, Daniel E.I. Schloss, Yunlong Liu, Guanglong Jiang, Bradley A. Hancock, Milan Radovich, Joshua K. Kays, Safi Shahda, Marion E. Couch, Leonidas G. Koniaris, Teresa A. Zimmers

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pancreatic cancer; RNAseq; Humans; Weight loss; Prognosis; Rectus Abdominis; Carcinoma, Pancreatic Ductal; Adipose Tissue; Pancreatic Carcinoma; Pancreatic Neoplasms; Subcutaneous Fat; High-Throughput Nucleotide Sequencing; Body Composition; Muscles; Cachexia; Muscular Atrophy; Gene Expression

Online: 26 March 2021 (11:24:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202002.0397.v1

What are the Impacts of Sugarcane Production on Ecosystem Services? A Review

Daniel EL CHAMI, André DACCACHE, Maroun EL MOUJABBER

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Sugarcane, impacts, ecosystem services, human well-being, agro-systems, sustainability

Online: 27 February 2020 (10:56:50 CET)

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Since the 1950s sugarcane production has grown rapidly from less than 0.5 billion tonnes in the late 50s to reach over 1.9 billion tonnes in 2012 on about 27 million hectares of agricultural land. This expansion has been boosted by the high demand for bioethanol promoted as a sustainable bioenergy source which accounted in 2010 for the biggest share of the global biofuel market. Despite its benefits, the scientific debate on sugar is growing especially that counterarguments are so many, including negative impacts on different interacting ecosystems and human well-being, e.g. bigger stress on land and water resources, environmental externalities on air, a harmful impact on the biodiversity and endemic species, negative environmental externalities, health, and socio-economic aspects. This paper provides a narrative systematic review (SR) of the impacts of sugarcane production on these different ecosystems employing the ecosystem services framework for its acceptance by policy-makers. The references included for the SR were 163 and results showed that the majority of the studies are from Brazil, Australia, South Africa and the USA (≈ 75% of the literature), most of them were from peer-reviewed journals (85%), and most of the case studies adopted a quantitative research approach (93%). The literature assessed showed that sugarcane, like all agro-systems, depends on the practices and techniques to transform negative impacts into positive externalities on ecosystems and human well-being. However, the literature studied failed to include the inter-linkage in sugarcane production impacts’ and therefore to evaluate the related ecosystem services with respect to the Millennium Ecosystem Assessment (MA) framework to account for existing trade-offs. Therefore, the findings are addressed to the scientific community and decision-maker for an intensification of interdisciplinary and integrated research based on the MA framework to cover all ecosystem services, for sustainable development of the sugarcane sector.

Preprint ARTICLE | doi:10.20944/preprints201906.0104.v1

Cycle-consistent Generative Adversarial Networks (CycleGANs) for the Non-Parallel Creation of Fake Voice Media

Daniel Fleury, Angelica Fleury

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Deep Learning, Generative Adversarial Networks (GANs), Machine Learning, Autoencoders, Voice Conversion, Ethics, CycleGANs

Online: 12 June 2019 (11:17:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0144.v1

Adaptable Energy Systems Integration by Modular, Standardized and Scalable System Architectures: Necessities and Prospects of Any Time Transition

Jonas Hinker, Thomas Wohlfahrt, Emily Drewing, Sergio Felipe Contreras Paredes, Daniel Mayorga Gonzalez, Johanna M.A. Myrzik

Subject: Engineering, Electrical And Electronic Engineering Keywords: energy infrastructure design; system architecture; energy transition; district heating systems (DHS); energy hubs; distributed multigeneration (DMG); multi-energy systems (MES); urban energy systems (UES); community energy; societal prospects

Online: 22 February 2018 (12:47:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0132.v1

Conceal Carry and Race: A Test of Minority Threat Theory in Law Generation

Christopher W. Mullins, Daniel R. Kavish

Subject: Social Sciences, Sociology Keywords: minority threat; conceal carry laws; Missouri; race and ethnicity

Online: 27 September 2017 (02:03:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0083.v1

Spatiotemporal Distribution of Satellite-Retrieved Ground-Level PM_2.5 and Near Real-Time Daily Retrieval Algorithm Development in Sichuan Basin, China

Chao Gao, Xuelei Zhang, Wenyong Wang, Aijun Xiu, Daniel Q. Tong, Weiwei Chen

Subject: Environmental And Earth Sciences, Environmental Science Keywords: particulate matter; AOD; planetary vertical corrections; humidity corrections

Online: 10 January 2018 (03:16:02 CET)

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Satellite-based monitoring can retrieve ground-level PM_2.5 concentrations with higher-resolution and continuous spatial coverage to assist in making management strategies and estimating health exposures. The Sichuan Basin has a complex terrain and several city clusters that differ from other regions in China: it has an enclosed air basin with a unique planetary boundary layer dynamic which accumulates air pollution. The spatiotemporal distribution of 1-km resolution Aerosol Optical Depth (AOD) in the Sichuan Basin was retrieved using the improved dark pixel method and Moderate Resolution Imaging Spectroradiometer (MODIS) data in this study. The retrieved seasonal AOD reached its highest values in spring and had the lowest values in autumn. The higher correlation (r = 0.84, N = 171) between the ground-based Lidar AOD and 1-km resolution MODIS AOD indicated that the high-resolution MODIS AOD could be used to retrieve the ground-level PM_2.5concentration. The Lidar-measured annual average extinction coefficient increased linearly with the Planetary Boundary Layer Height (PBLH) in the range of 100 ~ 670 m, but exponentially decreased between the heights of 670 ~ 1800 m. Both the correlation and the variation tendency of simulated PBLH from WRF_SHIN/CALMET were closer to the Lidar observation than that of three other Planetary Boundary Layer (PBL) schemes (the Grenier-Bretherton-McCaa (GBM) scheme, the he Total Energy-Mass Flux (TEMF) scheme and the University of Washington (UW) scheme), which suggested that the simulated PBLH could be used in the vertical correction of retrieval PM_2.5. Four seasonal fitting functions were also obtained for further humidity correction. The correlation coefficient between the aerosol extinction coefficient and the fitted surface-level PM_2.5 concentration at the benchmark station of Southwest Jiao-tong University was enhanced significantly from 0.62 to 0.76 after vertical and humidity corrections during a whole year. During the evaluation of the retrieved ground-level PM_2.5 with observed values from three cities, Yibin (YB), Dazhou (DZ), and Deyang (DY), our algorithm performed well, resulting in higher correlation coefficients of 0.78 (N = 177), 0.77 (N = 178), and 0.81 (N = 181), respectively.

Preprint CASE REPORT | doi:10.20944/preprints202311.1692.v1

One-Year Real-World Experience with Mavacamten and its Physiologic Effects on Obstructive Hypertrophic Cardiomyopathy

Daniel Kim, Emily Chu, Emily Keamy-Minor, Ishan Paranjpe, Wilson Tang, Jack O'Sullivan, Yaanik Desai, Michael Liu, Elise Munsey, Kimberly Hecker, Isabella Cuenco, Beth Kao, Ellen Bacolor, Colleen Bonnett, Andrea Linder, Kathleen Lacar, Nancy Robles, Cynthia Lamendola, Allysonne Smith, Joshua Knowles, Marco Perez, Masataka Kawana, Karim Sallam, Chad Weldy, Matthew Wheeler, Victoria Parikh, Heidi Salisbury, Euan Ashley

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mavacamten; cardiac myosin inhibitor; hypertrophic cardiomyopathy; heart failure

Online: 27 November 2023 (11:50:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0197.v1

Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications

Aarón Cruz-Ramírez, Raúl Sánchez-Olvera, Diego Zamarrón-Hernández, Mathieu Hautefeuille, Lucia Cabriales, Edgar Jiménez-Díaz, Beatriz Díaz-Bello, Jehú López-Aparicio, Daniel Pérez-Calixto, Mariel Cano-Jorge, Genaro Vázquez-Victorio

Subject: Chemistry And Materials Science, Biomaterials Keywords: laser micromachining; scaffold; biomimetics; microadditive manufacturing; microsubtractive manufacturing

Online: 23 March 2018 (08:00:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0235.v2

Why and How We Should Join the Shift From Significance Testing to Estimation

Daniel Berner, Valentin Amrhein

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Compatibility interval; effect size; null hypothesis; p-value; statistical inference

Online: 23 March 2022 (09:30:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0073.v1

Hospital-based RNA Therapeutics

Tulsi Damase, Roman Sukhovershin, Min Zhang, Daniel Kiss, John Cooke

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Messenger RNA • Hospital-based mRNA therapeutics • circular mRNA • self-amplifying mRNA • RNA-based CAR T-cell • RNA-based gene-editing tools

Online: 6 January 2022 (11:20:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0024.v1

Assuring SME’s Sustainable Competitiveness in the Digital Era. A Labour Policy between Minimum Wage Guaranteed and ICT Skill Mismatch

Alexandru Avram, Ginevra Gravili, Marco Benvenuto, Costin Daniel Avram

Subject: Business, Economics And Management, Economics Keywords: ICT skills mismatch, guaranteed minimum wage, SME’s sustainable competitiveness, employment, public policies

Online: 1 April 2019 (14:00:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0162.v1

Anxiety, Impaired Social and Aggressive Behaviour Correlates With Cognitive Decline Accompanied by Molecular Alterations in Older SAMP8 Males

Foteini Vasilopoulou, Júlia Companys-Alemany, Anna-Maria Canudas, Verónica Palomera-Ávalos, Daniel Ortuño-Sahagún, Mercè Pallàs, Christian Griñán-Ferré

Subject: Social Sciences, Psychology Keywords: behaviour; BPSD; cognitive decline; aging; SAMP8.

Online: 8 January 2021 (13:48:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0286.v1

Carbon Lock-in and Contradictions – Teaching Mexico’s Energy Transition

Ariel Macaspac Hernandez, Daniel Alejandro Pacheco Rojas, Diana Barrón Villaverde

Subject: Business, Economics And Management, Accounting And Taxation Keywords: sustainable energy; renewable energies; energy transitions; transformation to sustainability; policy analysis; grass-root movements; indigenous communities

Online: 10 June 2021 (09:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0080.v1

Community Detection Problem Based on Polarization Measures. An application to Twitter: the COVID-19 case in Spain

Inmaculada Gutiérrez García-Pardo, Juan Antonio Guevara Gil, Daniel Gómez González, Javier Castro Cantalejo, Rosa Espínola Vílchez

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Networks; Community Detection; Extended Fuzzy Graphs; Polarization; Fuzzy Sets; Ordinal Variation

Online: 5 January 2021 (11:18:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0118.v1

From FAANG to Fork: Application of Highly Annotated Genomes to Improve Farmed Animal Production

Emily L Clark, Alan L Archibald, Hans D Daetwyler, Martien AM Groenen, Peter W Harrison, Ross D Houston, Christa Kuehn, Sigbjorn Lien, Daniel J Macqueen, James M Reecy, Diego Robledo, Mick Watson, Christopher K Tuggle, Elisabetta Giuffra

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: FAANG; farmed animal; genomics; genotype-to-phenotype

Online: 6 October 2020 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0338.v1

Influences on Attitudes regarding Potential COVID-19 Vaccination in the United States

Kendall Pogue, Jamie Jensen, Carter Stancil, Daniel Ferguson, Savannah Hughes, Emily Mello, Ryan Burgess, Bradford Berges, Abraham Quaye, Brian D. Poole

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; vaccine hesitancy; vaccine attitudes; vaccine development; SARS-CoV-2

Online: 15 September 2020 (10:32:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0148.v2

Establishing Relationships between Drought and Wildfire Danger Indices: A Test Case for the California-Nevada Drought Early Warning System

Daniel J. McEvoy, Mike T. Hobbins, Tim J. Brown, Kristin VanderMolen, Tamara Wall, Justin L. Huntington, Mark Svoboda

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: drought; wildfire; drought index; fuel moisture; California; Nevada; evaporative demand

Online: 1 March 2019 (09:40:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0140.v1

Influence of Alkali Metal Substitution on the Phase Transition Behavior of CsGaQ2 (Q = S, Se)

Daniel Friedrich, Marc Schlosser, Martin Etter, Arno Pfitzner

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: chalcogenogallates; polymorphism; solid solutions; in situ X-ray diffraction; synchrotron radiation; rietveld refinement

Online: 20 October 2017 (12:53:24 CEST)

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